SEC13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.00950576
2proteasome assembly (GO:0043248)4.47708239
3negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.40324076
4formation of translation preinitiation complex (GO:0001731)4.39362963
5protein deneddylation (GO:0000338)4.33221694
6cullin deneddylation (GO:0010388)4.32667365
7ribosomal small subunit assembly (GO:0000028)4.31667265
8DNA deamination (GO:0045006)4.27976648
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.14540931
10Golgi transport vesicle coating (GO:0048200)4.11704331
11COPI coating of Golgi vesicle (GO:0048205)4.11704331
12regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.11635045
13anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.09583928
14negative regulation of ligase activity (GO:0051352)4.06510161
15negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.06510161
16nucleobase biosynthetic process (GO:0046112)3.96904558
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.94970649
18proline biosynthetic process (GO:0006561)3.89657691
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.83657275
20purine nucleobase biosynthetic process (GO:0009113)3.81373287
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.80876134
22protein retention in ER lumen (GO:0006621)3.80281443
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.78471628
24signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.78471628
25DNA strand elongation involved in DNA replication (GO:0006271)3.76983709
26signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.76021012
27signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.76021012
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.76021012
29regulation of cellular amino acid metabolic process (GO:0006521)3.75349395
30folic acid-containing compound biosynthetic process (GO:0009396)3.73877087
31signal transduction involved in DNA integrity checkpoint (GO:0072401)3.68570111
32signal transduction involved in DNA damage checkpoint (GO:0072422)3.68570111
33maturation of SSU-rRNA (GO:0030490)3.68297700
34positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.63060122
35signal transduction involved in cell cycle checkpoint (GO:0072395)3.62432149
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.61666004
37DNA strand elongation (GO:0022616)3.59693275
38L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.56243818
39antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.56040390
40cotranslational protein targeting to membrane (GO:0006613)3.53545142
41telomere maintenance via semi-conservative replication (GO:0032201)3.52044877
42protein targeting to ER (GO:0045047)3.51620623
43positive regulation of ligase activity (GO:0051351)3.49725871
44ribosomal large subunit biogenesis (GO:0042273)3.43108296
45establishment of viral latency (GO:0019043)3.42261918
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.39720569
47DNA replication initiation (GO:0006270)3.39451777
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38400694
49establishment of integrated proviral latency (GO:0075713)3.38033670
50tRNA aminoacylation for protein translation (GO:0006418)3.37662474
51ribosome assembly (GO:0042255)3.37193247
52maturation of 5.8S rRNA (GO:0000460)3.34884503
53protein localization to endoplasmic reticulum (GO:0070972)3.34557782
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31600694
55translation (GO:0006412)3.30979557
56* COPII vesicle coating (GO:0048208)3.30958516
57viral transcription (GO:0019083)3.28646744
58regulation of ubiquitin-protein transferase activity (GO:0051438)3.28271755
59tRNA aminoacylation (GO:0043039)3.27695342
60amino acid activation (GO:0043038)3.27695342
61ribosome biogenesis (GO:0042254)3.27593435
62translational termination (GO:0006415)3.25270920
63ribonucleoprotein complex biogenesis (GO:0022613)3.22961700
64mitotic metaphase plate congression (GO:0007080)3.22224662
65DNA replication checkpoint (GO:0000076)3.21990701
66transcription elongation from RNA polymerase III promoter (GO:0006385)3.21130036
67termination of RNA polymerase III transcription (GO:0006386)3.21130036
68translational initiation (GO:0006413)3.20775569
69IMP biosynthetic process (GO:0006188)3.20598310
70regulation of translational fidelity (GO:0006450)3.20368565
71regulation of ligase activity (GO:0051340)3.18591182
72ribosomal small subunit biogenesis (GO:0042274)3.18060629
73telomere maintenance via recombination (GO:0000722)3.17953753
74positive regulation of cell cycle arrest (GO:0071158)3.17541511
75translational elongation (GO:0006414)3.16920801
76rRNA modification (GO:0000154)3.16350316
77nucleotide-sugar biosynthetic process (GO:0009226)3.12022883
78energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12007681
79ATP synthesis coupled proton transport (GO:0015986)3.12007681
80cell cycle G1/S phase transition (GO:0044843)3.09982173
81G1/S transition of mitotic cell cycle (GO:0000082)3.09982173
82signal peptide processing (GO:0006465)3.07332150
83spliceosomal snRNP assembly (GO:0000387)3.05176702
84* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.03116462
85protein targeting to mitochondrion (GO:0006626)3.02068847
867-methylguanosine mRNA capping (GO:0006370)3.01542380
87rRNA processing (GO:0006364)3.01425177
88DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.01170906
89transcription-coupled nucleotide-excision repair (GO:0006283)3.00861463
90NADH metabolic process (GO:0006734)2.95622496
91GDP-mannose metabolic process (GO:0019673)2.95362493
92nucleobase-containing small molecule interconversion (GO:0015949)2.94887895
93tricarboxylic acid cycle (GO:0006099)2.94312700
94L-methionine biosynthetic process (GO:0071265)2.91866853
95amino acid salvage (GO:0043102)2.91866853
96L-methionine salvage (GO:0071267)2.91866853
977-methylguanosine RNA capping (GO:0009452)2.90909484
98RNA capping (GO:0036260)2.90909484
99DNA replication-dependent nucleosome assembly (GO:0006335)2.90030239
100DNA replication-dependent nucleosome organization (GO:0034723)2.90030239
101peptidyl-histidine modification (GO:0018202)2.88200757
102chaperone-mediated protein transport (GO:0072321)2.87822702
103CENP-A containing nucleosome assembly (GO:0034080)2.87513634
104rRNA metabolic process (GO:0016072)2.86879902
105mitotic recombination (GO:0006312)2.86829311
106mitotic nuclear envelope reassembly (GO:0007084)2.84646378
107nuclear envelope reassembly (GO:0031468)2.84646378
108regulation of mitochondrial translation (GO:0070129)2.84118868
109mitotic nuclear envelope disassembly (GO:0007077)2.83231162
110pseudouridine synthesis (GO:0001522)2.82976990
111deoxyribonucleotide biosynthetic process (GO:0009263)2.82912895
112pteridine-containing compound biosynthetic process (GO:0042559)2.82769844
113tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81272054
114RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81272054
115telomere maintenance via telomere lengthening (GO:0010833)2.81044196
116IMP metabolic process (GO:0046040)2.79436999
117dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.79187125
118mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.78774869
119folic acid metabolic process (GO:0046655)2.77770824
120viral mRNA export from host cell nucleus (GO:0046784)2.76107819
121protein localization to kinetochore (GO:0034501)2.75861614
122chromatin remodeling at centromere (GO:0031055)2.75379816
123proline metabolic process (GO:0006560)2.74465203
124negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73710073
125* vesicle coating (GO:0006901)2.73440593
126establishment of protein localization to mitochondrion (GO:0072655)2.73150564
127establishment of protein localization to mitochondrial membrane (GO:0090151)2.72849043
128regulation of cellular amine metabolic process (GO:0033238)2.72805492
129oxidative phosphorylation (GO:0006119)2.72599418
130guanosine-containing compound biosynthetic process (GO:1901070)2.69774320
131L-serine metabolic process (GO:0006563)2.67666784
132regulation of mitotic spindle organization (GO:0060236)2.60414800
133protein localization to mitochondrion (GO:0070585)2.59448306
134negative regulation of protein ubiquitination (GO:0031397)2.57926015
135mitotic sister chromatid segregation (GO:0000070)2.56888509
136NADPH regeneration (GO:0006740)2.56574013
137pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.52295775
138respiratory electron transport chain (GO:0022904)2.52166086
139pentose-phosphate shunt (GO:0006098)2.50956829
140cellular component biogenesis (GO:0044085)2.50445557
141de novo protein folding (GO:0006458)2.49832369
142negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.46715565
1434-hydroxyproline metabolic process (GO:0019471)2.46681938
144negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.46165648
145regulation of spindle organization (GO:0090224)2.45323401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.46143087
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.15056228
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98019426
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.97527099
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.75445023
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.55507182
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.42938081
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.21443627
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15888418
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.07785840
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96986141
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75964286
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70174122
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61929472
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50022930
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48528935
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46641808
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41153206
19* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36759717
20XRN2_22483619_ChIP-Seq_HELA_Human2.35004663
21DCP1A_22483619_ChIP-Seq_HELA_Human2.32395336
22* VDR_23849224_ChIP-Seq_CD4+_Human2.31253881
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24135402
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.15961244
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14885055
26* GABP_19822575_ChIP-Seq_HepG2_Human2.12539465
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08479304
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07491970
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.97160497
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96730417
31* SRF_21415370_ChIP-Seq_HL-1_Mouse1.95351893
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95135061
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94618208
34ELK1_19687146_ChIP-ChIP_HELA_Human1.87072996
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85472696
36ZNF263_19887448_ChIP-Seq_K562_Human1.84378835
37AR_21909140_ChIP-Seq_LNCAP_Human1.79985233
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76787264
39TTF2_22483619_ChIP-Seq_HELA_Human1.74904093
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74223391
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72855383
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.71729503
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71449120
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71028875
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69142684
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68579599
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64724008
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61431021
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61003205
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58342480
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57155576
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56793705
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56038359
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54263075
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47248445
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45775597
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43412652
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.42561748
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38244262
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37653555
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36446967
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36370463
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.34054970
64KDM5A_27292631_Chip-Seq_BREAST_Human1.32038316
65TFEB_21752829_ChIP-Seq_HELA_Human1.29863806
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27818133
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26962664
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24353612
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22080546
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21860399
71CIITA_25753668_ChIP-Seq_RAJI_Human1.19485158
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19291536
73CLOCK_20551151_ChIP-Seq_293T_Human1.18557696
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16718183
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12561533
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10678933
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10320094
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09452713
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08609843
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08418101
81* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08038443
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07770289
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05670384
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03921067
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02170078
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01562002
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01482215
88* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01047136
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00860583
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99353458
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.99175170
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97708479
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97313204
94EGR1_19374776_ChIP-ChIP_THP-1_Human0.97269432
95ATF3_27146783_Chip-Seq_COLON_Human0.94706917
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94642331
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94470811
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94238454
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93705624
100CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92853459
101* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92785432
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92664959
103* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91933488
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89306665
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87485558
106MYC_18940864_ChIP-ChIP_HL60_Human0.86476420
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83118663
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82540206
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82435613
110RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81967304
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81855838
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81418501
113SPI1_23547873_ChIP-Seq_NB4_Human0.79899209
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79219094
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78359292
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78050787
117TP63_17297297_ChIP-ChIP_HaCaT_Human0.78001064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.61977844
2MP0008438_abnormal_cutaneous_collagen3.68532000
3MP0004957_abnormal_blastocyst_morpholog3.62865781
4MP0003806_abnormal_nucleotide_metabolis3.37888155
5MP0003077_abnormal_cell_cycle2.94198847
6MP0010094_abnormal_chromosome_stability2.90098526
7MP0003111_abnormal_nucleus_morphology2.87222988
8MP0008932_abnormal_embryonic_tissue2.47196362
9MP0005360_urolithiasis2.44099836
10MP0008007_abnormal_cellular_replicative2.42924652
11MP0008058_abnormal_DNA_repair2.24756485
12MP0003123_paternal_imprinting2.23620690
13MP0005503_abnormal_tendon_morphology2.23335914
14MP0003941_abnormal_skin_development2.20505772
15MP0006054_spinal_hemorrhage2.11537018
16MP0003186_abnormal_redox_activity2.09380090
17MP0009840_abnormal_foam_cell2.05697122
18MP0003950_abnormal_plasma_membrane2.02288994
19MP0003718_maternal_effect1.96566644
20MP0010030_abnormal_orbit_morphology1.95653423
21MP0010352_gastrointestinal_tract_polyps1.84738093
22MP0008260_abnormal_autophagy1.82686197
23MP0005275_abnormal_skin_tensile1.82504569
24MP0001730_embryonic_growth_arrest1.81900576
25MP0008057_abnormal_DNA_replication1.69877881
26MP0000350_abnormal_cell_proliferation1.61979829
27MP0001542_abnormal_bone_strength1.60517960
28MP0005023_abnormal_wound_healing1.60458692
29MP0002139_abnormal_hepatobiliary_system1.59995892
30MP0005408_hypopigmentation1.53998237
31MP0003786_premature_aging1.52943751
32MP0005058_abnormal_lysosome_morphology1.52005408
33MP0004233_abnormal_muscle_weight1.43773588
34MP0000490_abnormal_crypts_of1.37518424
35MP0003705_abnormal_hypodermis_morpholog1.31195383
36MP0009333_abnormal_splenocyte_physiolog1.30879765
37MP0001697_abnormal_embryo_size1.29003433
38MP0001661_extended_life_span1.28661582
39MP0002396_abnormal_hematopoietic_system1.27722239
40MP0006035_abnormal_mitochondrial_morpho1.25514654
41MP0003279_aneurysm1.22745056
42MP0002080_prenatal_lethality1.18457578
43MP0005380_embryogenesis_phenotype1.16726561
44MP0001672_abnormal_embryogenesis/_devel1.16726561
45MP0000358_abnormal_cell_content/1.15047296
46MP0002933_joint_inflammation1.14970088
47MP0000749_muscle_degeneration1.14671514
48MP0005220_abnormal_exocrine_pancreas1.13328226
49MP0001243_abnormal_dermal_layer1.12847344
50MP0000003_abnormal_adipose_tissue1.10824638
51MP0005501_abnormal_skin_physiology1.09592720
52MP0003984_embryonic_growth_retardation1.09509763
53MP0000537_abnormal_urethra_morphology1.09298945
54MP0005330_cardiomyopathy1.05911808
55MP0000313_abnormal_cell_death1.05738680
56MP0005508_abnormal_skeleton_morphology1.05403492
57MP0002088_abnormal_embryonic_growth/wei1.05069312
58MP0002132_abnormal_respiratory_system1.05041037
59MP0003566_abnormal_cell_adhesion1.03652728
60MP0002938_white_spotting1.02900675
61MP0002019_abnormal_tumor_incidence1.02035643
62MP0001915_intracranial_hemorrhage1.00859628
63MP0001666_abnormal_nutrient_absorption1.00668054
64MP0003385_abnormal_body_wall1.00307324
65MP0005623_abnormal_meninges_morphology0.99348050
66MP0002085_abnormal_embryonic_tissue0.98853751
67MP0010368_abnormal_lymphatic_system0.96516161
68MP0003315_abnormal_perineum_morphology0.95900628
69MP0000858_altered_metastatic_potential0.94076802
70MP0001529_abnormal_vocalization0.93384290
71MP0006036_abnormal_mitochondrial_physio0.93038636
72MP0009697_abnormal_copulation0.91596901
73MP0003191_abnormal_cellular_cholesterol0.91036062
74MP0005332_abnormal_amino_acid0.90513877
75MP0002111_abnormal_tail_morphology0.86936372
76MP0004272_abnormal_basement_membrane0.86802851
77MP0004197_abnormal_fetal_growth/weight/0.86410770
78MP0000678_abnormal_parathyroid_gland0.85988484
79MP0001881_abnormal_mammary_gland0.85488227
80MP0005365_abnormal_bile_salt0.84052851
81MP0000751_myopathy0.83521457
82MP0002084_abnormal_developmental_patter0.82651319
83MP0001727_abnormal_embryo_implantation0.80967149
84MP0005390_skeleton_phenotype0.80076136
85MP0010307_abnormal_tumor_latency0.77451836
86MP0005451_abnormal_body_composition0.77354012
87MP0002060_abnormal_skin_morphology0.76909950
88MP0009053_abnormal_anal_canal0.76047211
89MP0005395_other_phenotype0.76024533
90MP0002086_abnormal_extraembryonic_tissu0.74380406
91MP0005085_abnormal_gallbladder_physiolo0.74045951
92MP0003937_abnormal_limbs/digits/tail_de0.73749946
93MP0005165_increased_susceptibility_to0.73247216
94MP0004133_heterotaxia0.72265722
95MP0000750_abnormal_muscle_regeneration0.72264740
96MP0002877_abnormal_melanocyte_morpholog0.72009482
97MP0002295_abnormal_pulmonary_circulatio0.71401200
98MP0000762_abnormal_tongue_morphology0.71382921
99MP0001764_abnormal_homeostasis0.71141120
100MP0003763_abnormal_thymus_physiology0.70388715
101MP0009672_abnormal_birth_weight0.70322157
102MP0002282_abnormal_trachea_morphology0.69732827
103MP0002653_abnormal_ependyma_morphology0.69592072
104MP0005389_reproductive_system_phenotype0.69361748
105MP0002160_abnormal_reproductive_system0.69294184
106MP0000163_abnormal_cartilage_morphology0.69198121
107MP0009384_cardiac_valve_regurgitation0.68981671
108MP0005367_renal/urinary_system_phenotyp0.68966964
109MP0000516_abnormal_urinary_system0.68966964
110MP0000747_muscle_weakness0.68486778
111MP0005197_abnormal_uvea_morphology0.68026589
112MP0000049_abnormal_middle_ear0.67814887
113MP0005171_absent_coat_pigmentation0.67420108
114MP0002163_abnormal_gland_morphology0.67136708
115MP0005384_cellular_phenotype0.66958022
116MP0005193_abnormal_anterior_eye0.66708830
117MP0001849_ear_inflammation0.66524640
118MP0001958_emphysema0.66416477
119MP0008789_abnormal_olfactory_epithelium0.66126919
120MP0003221_abnormal_cardiomyocyte_apopto0.65919040
121MP0005266_abnormal_metabolism0.65897762
122MP0005257_abnormal_intraocular_pressure0.65487940
123MP0001119_abnormal_female_reproductive0.63771188
124MP0005084_abnormal_gallbladder_morpholo0.62794568
125MP0002113_abnormal_skeleton_development0.62468565
126MP0000013_abnormal_adipose_tissue0.62013098
127MP0003119_abnormal_digestive_system0.60998329
128MP0001533_abnormal_skeleton_physiology0.60917022
129MP0003567_abnormal_fetal_cardiomyocyte0.60154178
130MP0003795_abnormal_bone_structure0.60126576
131MP0009250_abnormal_appendicular_skeleto0.59418097
132MP0003942_abnormal_urinary_system0.59357646
133MP0005621_abnormal_cell_physiology0.58798408
134MP0004134_abnormal_chest_morphology0.58716045
135MP0000372_irregular_coat_pigmentation0.58443278
136MP0002210_abnormal_sex_determination0.57874890
137MP0002269_muscular_atrophy0.57513378

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)4.09339219
2Cholecystitis (HP:0001082)4.09339219
3Cerebral hypomyelination (HP:0006808)3.95713402
4Abnormality of the anterior horn cell (HP:0006802)3.52962795
5Degeneration of anterior horn cells (HP:0002398)3.52962795
6Birth length less than 3rd percentile (HP:0003561)3.52812115
7Irregular epiphyses (HP:0010582)3.36683570
8Breast hypoplasia (HP:0003187)3.32045785
9Carpal bone hypoplasia (HP:0001498)3.28399027
10Premature rupture of membranes (HP:0001788)3.18173085
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10201577
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10201577
13Abnormality of cells of the erythroid lineage (HP:0012130)3.06773325
14Protrusio acetabuli (HP:0003179)3.01796389
15Hepatic necrosis (HP:0002605)2.96468593
16Abnormal number of erythroid precursors (HP:0012131)2.88707414
17Rough bone trabeculation (HP:0100670)2.87024500
18Hepatocellular necrosis (HP:0001404)2.86169523
19Trismus (HP:0000211)2.79099718
20Microretrognathia (HP:0000308)2.78080580
21Microvesicular hepatic steatosis (HP:0001414)2.76642436
22Secondary amenorrhea (HP:0000869)2.75562493
23Reduced antithrombin III activity (HP:0001976)2.71686067
24Reticulocytopenia (HP:0001896)2.71162936
25Increased serum pyruvate (HP:0003542)2.67916147
26Abnormality of glycolysis (HP:0004366)2.67916147
27Upper limb muscle weakness (HP:0003484)2.64700794
28Multiple enchondromatosis (HP:0005701)2.63328085
29Aplastic anemia (HP:0001915)2.63178721
30Selective tooth agenesis (HP:0001592)2.61159153
31Oral leukoplakia (HP:0002745)2.59721264
32Type I transferrin isoform profile (HP:0003642)2.53145959
33Redundant skin (HP:0001582)2.46804509
34Generalized aminoaciduria (HP:0002909)2.45863188
35Acute necrotizing encephalopathy (HP:0006965)2.45032211
36Cervical subluxation (HP:0003308)2.44360620
37Mitochondrial inheritance (HP:0001427)2.44280178
38Entropion (HP:0000621)2.43634235
39Increased serum lactate (HP:0002151)2.43307343
40Delayed epiphyseal ossification (HP:0002663)2.41386517
41Abnormal mitochondria in muscle tissue (HP:0008316)2.40350521
42Cerebral edema (HP:0002181)2.39208560
4311 pairs of ribs (HP:0000878)2.38587538
44Soft skin (HP:0000977)2.36458537
45Small epiphyses (HP:0010585)2.36195117
46Increased CSF lactate (HP:0002490)2.36184006
47Poor head control (HP:0002421)2.34991107
48Flat capital femoral epiphysis (HP:0003370)2.32689434
49Abnormal delivery (HP:0001787)2.30596675
50Abnormality of the umbilical cord (HP:0010881)2.30518904
51Abnormality of the calcaneus (HP:0008364)2.29435141
52Nonimmune hydrops fetalis (HP:0001790)2.28852151
53Breech presentation (HP:0001623)2.27555655
54Macrocytic anemia (HP:0001972)2.27211892
55Abnormal trabecular bone morphology (HP:0100671)2.24694282
56Vertebral compression fractures (HP:0002953)2.24613027
57Glossoptosis (HP:0000162)2.24099275
58Absent epiphyses (HP:0010577)2.23489214
59Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.23489214
60Patellar aplasia (HP:0006443)2.21206574
61Hypobetalipoproteinemia (HP:0003563)2.21113961
62Abnormality of dentin (HP:0010299)2.21077212
63CNS hypomyelination (HP:0003429)2.20631472
64Progressive macrocephaly (HP:0004481)2.18155878
65Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14863185
66Aplasia/Hypoplasia of the patella (HP:0006498)2.14457606
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13075890
68Abnormality of methionine metabolism (HP:0010901)2.09205650
69Biconcave vertebral bodies (HP:0004586)2.08981586
70Abnormal protein glycosylation (HP:0012346)2.07843266
71Abnormal glycosylation (HP:0012345)2.07843266
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07843266
73Abnormal protein N-linked glycosylation (HP:0012347)2.07843266
74Acute encephalopathy (HP:0006846)2.07652629
75Hypokinesia (HP:0002375)2.06680854
76Ragged-red muscle fibers (HP:0003200)2.06013757
77Metaphyseal cupping (HP:0003021)2.03828816
78Slender long bone (HP:0003100)2.03119819
79Increased intramyocellular lipid droplets (HP:0012240)2.01355643
80Renal Fanconi syndrome (HP:0001994)2.00251685
81Orthostatic hypotension (HP:0001278)1.99979753
82Calcaneovalgus deformity (HP:0001848)1.99183288
83Beaking of vertebral bodies (HP:0004568)1.98999856
84Hand muscle atrophy (HP:0009130)1.98433214
85Hypoplasia of the pons (HP:0012110)1.97897990
86Genu varum (HP:0002970)1.97536547
87Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97114484
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94511426
89Cholelithiasis (HP:0001081)1.91496917
90CNS demyelination (HP:0007305)1.91242495
91Irregular vertebral endplates (HP:0003301)1.90479547
92Progressive muscle weakness (HP:0003323)1.89024956
93Upper limb amyotrophy (HP:0009129)1.88921280
94Distal upper limb amyotrophy (HP:0007149)1.88921280
95Pallor (HP:0000980)1.88691166
96Premature ovarian failure (HP:0008209)1.88592313
97Microglossia (HP:0000171)1.88582139
98Short nail (HP:0001799)1.87625394
99Abnormal gallbladder morphology (HP:0012437)1.87613408
100Premature graying of hair (HP:0002216)1.87467380
101Nausea (HP:0002018)1.86905128
102Deformed tarsal bones (HP:0008119)1.86284669
103Rhabdomyolysis (HP:0003201)1.85849956
104Cupped ribs (HP:0000887)1.85754366
105Achilles tendon contracture (HP:0001771)1.85514916
106Abnormality of the pons (HP:0007361)1.85432413
1073-Methylglutaconic aciduria (HP:0003535)1.84865835
108Testicular atrophy (HP:0000029)1.84341023
109Lactic acidosis (HP:0003128)1.82113870
110Respiratory failure (HP:0002878)1.81718189
111Abnormality of the fetal cardiovascular system (HP:0010948)1.81224378
112Abnormal umbilical cord blood vessels (HP:0011403)1.81224378
113Single umbilical artery (HP:0001195)1.81224378
114Platyspondyly (HP:0000926)1.80197580
115Ankle contracture (HP:0006466)1.79590235
116Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79524690
117Colon cancer (HP:0003003)1.79349744
118Reduced subcutaneous adipose tissue (HP:0003758)1.79221967
119Abnormality of the Achilles tendon (HP:0005109)1.78887928
120Postnatal microcephaly (HP:0005484)1.78611428
121Abnormalities of placenta or umbilical cord (HP:0001194)1.77512947
122Hypolipoproteinemia (HP:0010981)1.77486838
123Patent foramen ovale (HP:0001655)1.77429414
124Abnormal tarsal ossification (HP:0008369)1.76488758
125Coxa vara (HP:0002812)1.76455380
126Exercise intolerance (HP:0003546)1.75753753
127Sparse eyelashes (HP:0000653)1.75569058
128Elbow flexion contracture (HP:0002987)1.75400420
129Bladder diverticulum (HP:0000015)1.75155903
130Increased hepatocellular lipid droplets (HP:0006565)1.74775599
131Abnormality of the tricuspid valve (HP:0001702)1.74651375
132Lipid accumulation in hepatocytes (HP:0006561)1.74571142
133Generalized amyotrophy (HP:0003700)1.72271072
134Abnormal cartilage morphology (HP:0002763)1.71249812
135Hypertensive crisis (HP:0100735)1.71077853
136Abnormal foot bone ossification (HP:0010675)1.70886425
137Increased muscle lipid content (HP:0009058)1.70770372
138Spinal rigidity (HP:0003306)1.70430142
139Premature skin wrinkling (HP:0100678)1.70318931
140Follicular hyperkeratosis (HP:0007502)1.69106317
141Megaloblastic anemia (HP:0001889)1.68631721
142Neoplasm of the pancreas (HP:0002894)1.68489116
143Abnormality of subcutaneous fat tissue (HP:0001001)1.68397062
144Amniotic constriction ring (HP:0009775)1.67556530
145Abnormality of placental membranes (HP:0011409)1.67556530
146Hyperammonemia (HP:0001987)1.67075612
147Abnormality of the acetabulum (HP:0003170)1.66731760
148Cardiovascular calcification (HP:0011915)1.65948435
149Respiratory difficulties (HP:0002880)1.65778910
150Overlapping toe (HP:0001845)1.65237584
151Wormian bones (HP:0002645)1.64534213
152Missing ribs (HP:0000921)1.63216873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.07080562
2EIF2AK13.80594535
3TESK23.14137362
4VRK23.12881061
5NME23.00951439
6TESK12.69946252
7WEE12.67602657
8STK162.59843389
9EIF2AK32.52696274
10MAP3K122.16333128
11CDC72.13800151
12TSSK62.11896910
13LIMK12.04749742
14PASK1.96431575
15PIM21.93834034
16PLK41.82920018
17SRPK11.78883766
18TLK11.74930627
19BCKDK1.70426117
20BRSK21.68472911
21NEK11.65895509
22KDR1.61795941
23PBK1.58676741
24ACVR1B1.58220253
25TTK1.57541462
26VRK11.55859002
27RPS6KA41.44118006
28STK38L1.32804567
29PLK11.31265695
30ZAK1.30100475
31EPHA21.29951348
32NEK21.29071805
33AURKB1.28141583
34NME11.21371317
35SMG11.21266085
36PAK41.19686748
37AURKA1.18695997
38MAP3K31.14929554
39MAP3K111.13820474
40TGFBR11.09389973
41PLK31.08753107
42RPS6KB21.07829250
43PTK21.05838072
44DYRK31.05288277
45ILK1.03769316
46MAP3K81.03625319
47MST41.02664854
48BRSK11.01886517
49MST1R1.00790854
50LRRK20.99215532
51BRAF0.97151105
52DYRK20.96320171
53FLT30.95484383
54MYLK0.94438968
55CDK70.93653759
56PAK10.90324993
57MAPKAPK30.88537368
58DAPK10.88362085
59CLK10.88324215
60SCYL20.87622816
61MKNK10.87082489
62ERN10.85407150
63ATR0.83530385
64STK100.81628505
65CSNK1G30.77464807
66MET0.77002995
67RAF10.76667342
68CDK80.75312212
69ERBB40.73924221
70CHEK20.71756193
71ARAF0.71471399
72MOS0.69989167
73CCNB10.69554847
74PRKCI0.68575898
75PIK3CG0.68503654
76EIF2AK20.65925167
77ZAP700.65903466
78ICK0.65281354
79EPHB20.64945226
80CSNK1A1L0.64933912
81TRIM280.64833295
82ABL20.63774990
83AKT20.61491864
84PDGFRA0.60526276
85EEF2K0.59270935
86MAP2K30.58977902
87CSNK2A10.58432684
88CSNK1G10.55981480
89NEK90.54548183
90KSR20.54088404
91RPS6KA50.53200567
92STK40.53121325
93PIM10.52431026
94PRKG20.51326572
95TRIB30.50190456
96CHEK10.49465917
97CSNK2A20.47823089
98MAP2K20.47722652
99LMTK20.47418168
100DDR20.47290628
101NLK0.45367768
102FER0.43515982
103FGFR40.43386782
104TIE10.43338080
105IRAK30.42828629
106NUAK10.42541935
107TTN0.42022113
108CDK40.41475940
109IRAK40.41031045
110PDK20.40667796
111BCR0.40329011
112STK30.38022534
113PAK20.37606366
114TAOK20.36789245
115LATS20.36150551
116JAK30.34288878
117CDK140.33760151
118PLK20.32680486
119MAPKAPK50.31377615
120PKN20.31297886
121DAPK30.31125727
122PDK40.30278510
123PDK30.30278510
124OBSCN0.30066743
125CDK11A0.29763349
126PTK60.28817265
127MAPKAPK20.28246054
128CDK180.27888652
129CDK20.25517238
130ERBB30.25491476
131BTK0.25057642
132MELK0.24733933

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.65092785
2DNA replication_Homo sapiens_hsa030303.61116928
3Ribosome_Homo sapiens_hsa030103.31524165
4RNA polymerase_Homo sapiens_hsa030203.21022600
5Protein export_Homo sapiens_hsa030603.13669894
6Mismatch repair_Homo sapiens_hsa034302.89554284
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75185317
8Base excision repair_Homo sapiens_hsa034102.48279976
9Spliceosome_Homo sapiens_hsa030402.42892097
10Pyrimidine metabolism_Homo sapiens_hsa002402.36906960
11Nucleotide excision repair_Homo sapiens_hsa034202.30375705
12* RNA transport_Homo sapiens_hsa030132.26030155
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24076125
14One carbon pool by folate_Homo sapiens_hsa006702.17569155
15Homologous recombination_Homo sapiens_hsa034402.06015740
16Cell cycle_Homo sapiens_hsa041101.89641406
17Folate biosynthesis_Homo sapiens_hsa007901.73139777
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.58687421
19Basal transcription factors_Homo sapiens_hsa030221.51376274
20Oxidative phosphorylation_Homo sapiens_hsa001901.51093846
21RNA degradation_Homo sapiens_hsa030181.49371657
22Non-homologous end-joining_Homo sapiens_hsa034501.47205073
23Parkinsons disease_Homo sapiens_hsa050121.46229757
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42914990
25* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29484132
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26732916
27Purine metabolism_Homo sapiens_hsa002301.26732537
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26029953
29p53 signaling pathway_Homo sapiens_hsa041151.22866948
30Huntingtons disease_Homo sapiens_hsa050161.17949571
31Fanconi anemia pathway_Homo sapiens_hsa034601.15163393
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11244605
33Glutathione metabolism_Homo sapiens_hsa004801.10933622
34Selenocompound metabolism_Homo sapiens_hsa004501.08486847
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06661387
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02121200
37Sulfur relay system_Homo sapiens_hsa041221.01290764
38Epstein-Barr virus infection_Homo sapiens_hsa051690.98065757
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94937930
40Biosynthesis of amino acids_Homo sapiens_hsa012300.94300081
41Systemic lupus erythematosus_Homo sapiens_hsa053220.93575459
42Pentose phosphate pathway_Homo sapiens_hsa000300.93252981
43Propanoate metabolism_Homo sapiens_hsa006400.92802021
44Arginine biosynthesis_Homo sapiens_hsa002200.91875673
45N-Glycan biosynthesis_Homo sapiens_hsa005100.91659642
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.89897546
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89575688
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.88649439
49Sulfur metabolism_Homo sapiens_hsa009200.88077190
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.87450657
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87072620
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86020660
53Carbon metabolism_Homo sapiens_hsa012000.84690379
54Vitamin B6 metabolism_Homo sapiens_hsa007500.82887407
55Fatty acid metabolism_Homo sapiens_hsa012120.80657101
56Legionellosis_Homo sapiens_hsa051340.78638070
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76632776
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75965275
59Galactose metabolism_Homo sapiens_hsa000520.74596637
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.71176681
61mRNA surveillance pathway_Homo sapiens_hsa030150.70385361
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69245317
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69232445
64Antigen processing and presentation_Homo sapiens_hsa046120.67543407
65Fructose and mannose metabolism_Homo sapiens_hsa000510.66081673
66Viral carcinogenesis_Homo sapiens_hsa052030.63229993
67Alzheimers disease_Homo sapiens_hsa050100.62978713
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62758990
69Arachidonic acid metabolism_Homo sapiens_hsa005900.60844670
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59282984
71Metabolic pathways_Homo sapiens_hsa011000.58501509
72Arginine and proline metabolism_Homo sapiens_hsa003300.58349281
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57996554
74Steroid biosynthesis_Homo sapiens_hsa001000.54898756
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51065404
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.50771519
77Peroxisome_Homo sapiens_hsa041460.50339186
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49497419
79Pyruvate metabolism_Homo sapiens_hsa006200.48855101
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.48448500
81Vibrio cholerae infection_Homo sapiens_hsa051100.46739264
82Other glycan degradation_Homo sapiens_hsa005110.45452403
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.44391325
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42994676
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41246876
86Regulation of autophagy_Homo sapiens_hsa041400.41172021
87Fatty acid degradation_Homo sapiens_hsa000710.39247232
88Herpes simplex infection_Homo sapiens_hsa051680.39188118
89Shigellosis_Homo sapiens_hsa051310.38586513
90Fatty acid elongation_Homo sapiens_hsa000620.37878452
91Thyroid cancer_Homo sapiens_hsa052160.37735374
92HTLV-I infection_Homo sapiens_hsa051660.37083965
93Protein digestion and absorption_Homo sapiens_hsa049740.35124872
94TGF-beta signaling pathway_Homo sapiens_hsa043500.34929368
95Linoleic acid metabolism_Homo sapiens_hsa005910.34901198
96Bladder cancer_Homo sapiens_hsa052190.31999415
97Apoptosis_Homo sapiens_hsa042100.31801924
98Renin-angiotensin system_Homo sapiens_hsa046140.31097565
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31026225
100Starch and sucrose metabolism_Homo sapiens_hsa005000.29031696
101Complement and coagulation cascades_Homo sapiens_hsa046100.29012704
102ECM-receptor interaction_Homo sapiens_hsa045120.27894456
103Fat digestion and absorption_Homo sapiens_hsa049750.27706202
104Sphingolipid metabolism_Homo sapiens_hsa006000.25986541
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25962524
106Phagosome_Homo sapiens_hsa041450.25105226
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24791894
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24688347
109Tyrosine metabolism_Homo sapiens_hsa003500.24100646
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22236170
111Oocyte meiosis_Homo sapiens_hsa041140.21973064
112Hippo signaling pathway_Homo sapiens_hsa043900.21174443
113Cardiac muscle contraction_Homo sapiens_hsa042600.21067436
114Vitamin digestion and absorption_Homo sapiens_hsa049770.20901335
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20677063
116Phenylalanine metabolism_Homo sapiens_hsa003600.19983786
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19543710
118Small cell lung cancer_Homo sapiens_hsa052220.18315097
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18254752

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