SEC13P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sexual reproduction (GO:0019953)9.15029708
2serotonin receptor signaling pathway (GO:0007210)6.66248124
3sequestering of actin monomers (GO:0042989)6.41142684
4regulation of meiosis I (GO:0060631)5.96008786
5sister chromatid cohesion (GO:0007062)5.20030267
6nuclear pore complex assembly (GO:0051292)5.06938763
7nuclear pore organization (GO:0006999)4.94805783
8fusion of sperm to egg plasma membrane (GO:0007342)4.92366160
9melanin biosynthetic process (GO:0042438)4.83643013
10melanin metabolic process (GO:0006582)4.79733060
11synaptonemal complex assembly (GO:0007130)4.72668231
12reproduction (GO:0000003)4.58087699
13removal of superoxide radicals (GO:0019430)4.28260620
14cellular response to superoxide (GO:0071451)4.28260620
15cellular response to oxygen radical (GO:0071450)4.28260620
16acrosome reaction (GO:0007340)4.25629997
17synaptonemal complex organization (GO:0070193)4.13836426
18protein kinase C signaling (GO:0070528)4.11615343
19pore complex assembly (GO:0046931)4.11229705
20Golgi to endosome transport (GO:0006895)4.04773800
21negative regulation of meiosis (GO:0045835)4.00030553
22positive regulation of granulocyte differentiation (GO:0030854)3.99003771
23blastocyst development (GO:0001824)3.93342780
24response to superoxide (GO:0000303)3.92111265
25proteasome assembly (GO:0043248)3.87910344
26nitric oxide biosynthetic process (GO:0006809)3.81543875
27plasma membrane fusion (GO:0045026)3.79568795
28chromosome organization involved in meiosis (GO:0070192)3.77923972
29response to oxygen radical (GO:0000305)3.73906237
30secondary metabolite biosynthetic process (GO:0044550)3.70273337
31sperm motility (GO:0030317)3.66282548
32DNA deamination (GO:0045006)3.65001518
33positive regulation of cellular response to oxidative stress (GO:1900409)3.47122023
34positive regulation of response to oxidative stress (GO:1902884)3.47122023
35regulation of histone H3-K27 methylation (GO:0061085)3.44306647
36nuclear envelope disassembly (GO:0051081)3.41764681
37membrane disassembly (GO:0030397)3.41764681
38histone mRNA catabolic process (GO:0071044)3.41199495
39definitive hemopoiesis (GO:0060216)3.39321173
40regulation of mRNA catabolic process (GO:0061013)3.32745337
41positive regulation of endothelial cell differentiation (GO:0045603)3.30625468
42male meiosis I (GO:0007141)3.29006313
43positive T cell selection (GO:0043368)3.27840403
44mitotic nuclear envelope disassembly (GO:0007077)3.27767252
45meiotic nuclear division (GO:0007126)3.25522866
46phosphatidylethanolamine metabolic process (GO:0046337)3.21527667
47cellular response to ethanol (GO:0071361)3.20685282
48phosphatidylethanolamine biosynthetic process (GO:0006646)3.18937373
49rRNA catabolic process (GO:0016075)3.12299818
50multicellular organism reproduction (GO:0032504)3.10610850
51negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.09971862
52regulation of transcription involved in cell fate commitment (GO:0060850)3.09903381
53DNA packaging (GO:0006323)3.04156731
54DNA methylation involved in gamete generation (GO:0043046)3.04002782
55meiotic cell cycle process (GO:1903046)3.03768837
56male meiosis (GO:0007140)3.03549801
57coenzyme catabolic process (GO:0009109)3.03241169
58negative regulation of acute inflammatory response (GO:0002674)3.02610235
59piRNA metabolic process (GO:0034587)3.00674805
60regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.98035754
61single strand break repair (GO:0000012)2.97253366
62regulation of granulocyte differentiation (GO:0030852)2.94614355
63genitalia morphogenesis (GO:0035112)2.92069078
64rRNA methylation (GO:0031167)2.91481300
65regulation of endothelial cell differentiation (GO:0045601)2.86527506
66positive regulation of gamma-delta T cell activation (GO:0046645)2.86204604
67regulation of helicase activity (GO:0051095)2.84902181
68establishment of protein localization to Golgi (GO:0072600)2.82937211
69hepatocyte apoptotic process (GO:0097284)2.82738973
70microtubule depolymerization (GO:0007019)2.81023540
71membrane protein intracellular domain proteolysis (GO:0031293)2.80709057
72negative T cell selection (GO:0043383)2.79850383
73mitochondrial DNA replication (GO:0006264)2.79527642
74interkinetic nuclear migration (GO:0022027)2.79392963
75positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.79127996
76centriole replication (GO:0007099)2.79080635
77meiotic chromosome segregation (GO:0045132)2.78740893
78dendritic cell migration (GO:0036336)2.76480851
79sperm capacitation (GO:0048240)2.75936457
80positive regulation of Rab GTPase activity (GO:0032851)2.74798689
81regulation of Rab GTPase activity (GO:0032313)2.74798689
82DNA synthesis involved in DNA repair (GO:0000731)2.74306008
83keratinocyte development (GO:0003334)2.72440862
84negative regulation of meiotic cell cycle (GO:0051447)2.72233669
85DNA topological change (GO:0006265)2.70623457
86regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.68059946
87positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.68059946
88purinergic nucleotide receptor signaling pathway (GO:0035590)2.64996198
89regulation of chromosome segregation (GO:0051983)2.63728727
90positive regulation of B cell differentiation (GO:0045579)2.63610698
91oocyte development (GO:0048599)2.62640019
92cell wall macromolecule metabolic process (GO:0044036)2.62460057
93negative thymic T cell selection (GO:0045060)2.59264020
94protein targeting to lysosome (GO:0006622)2.59136191
95establishment of protein localization to vacuole (GO:0072666)2.59136191
96protein targeting to vacuole (GO:0006623)2.59136191
97nucleus organization (GO:0006997)2.58962603
98positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.58362622
99regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.58362622
100DNA replication checkpoint (GO:0000076)2.58096993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.82245606
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.80707195
3VDR_22108803_ChIP-Seq_LS180_Human3.34126215
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.55663787
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44612103
6GATA1_22025678_ChIP-Seq_K562_Human2.40883444
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.39614249
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.31120348
9E2F7_22180533_ChIP-Seq_HELA_Human2.18856258
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.04950349
11PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.03427639
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.96640695
13MYB_26560356_Chip-Seq_TH2_Human1.88728460
14TAF15_26573619_Chip-Seq_HEK293_Human1.85421602
15GATA3_26560356_Chip-Seq_TH2_Human1.82596697
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80226296
17VDR_23849224_ChIP-Seq_CD4+_Human1.78700857
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74105731
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.69972581
20MYB_26560356_Chip-Seq_TH1_Human1.68368221
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64074648
22KDM5A_27292631_Chip-Seq_BREAST_Human1.62253188
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.51589727
24RUNX_20019798_ChIP-Seq_JUKART_Human1.46253477
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44707973
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42713894
27ER_23166858_ChIP-Seq_MCF-7_Human1.39995048
28GATA3_27048872_Chip-Seq_THYMUS_Human1.39778543
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30363785
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30299033
31DCP1A_22483619_ChIP-Seq_HELA_Human1.29243043
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29235092
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28928110
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26757738
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23936420
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.22866539
37IGF1R_20145208_ChIP-Seq_DFB_Human1.22597075
38TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22297062
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22080239
40GATA3_26560356_Chip-Seq_TH1_Human1.21244374
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21009681
42FUS_26573619_Chip-Seq_HEK293_Human1.20555794
43AR_21572438_ChIP-Seq_LNCaP_Human1.19876350
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19046586
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18571379
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.17481875
47SPI1_23127762_ChIP-Seq_K562_Human1.16719099
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14689528
49CIITA_25753668_ChIP-Seq_RAJI_Human1.14664367
50MAF_26560356_Chip-Seq_TH2_Human1.14405999
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.13889885
52RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11761283
53HOXB7_26014856_ChIP-Seq_BT474_Human1.08984754
54MAF_26560356_Chip-Seq_TH1_Human1.08577186
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08531083
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08425306
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08394339
58BCL6_27268052_Chip-Seq_Bcells_Human1.08385333
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06978799
60SPI1_23547873_ChIP-Seq_NB4_Human1.06580040
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06299698
62ELK1_19687146_ChIP-ChIP_HELA_Human1.05842986
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05825906
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04429163
65SMC4_20622854_ChIP-Seq_HELA_Human1.02486596
66TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.02352356
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02262911
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01916397
69ERA_21632823_ChIP-Seq_H3396_Human1.01652683
70GATA3_21867929_ChIP-Seq_TH1_Mouse0.99493583
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97904302
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97741723
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97218000
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97189540
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96598884
76P300_27268052_Chip-Seq_Bcells_Human0.95132502
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94328002
78CEBPB_22108803_ChIP-Seq_LS180_Human0.93020835
79SCL_19346495_ChIP-Seq_HPC-7_Human0.90891399
80RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90880152
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90818396
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.90459563
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90076612
84PHF8_20622854_ChIP-Seq_HELA_Human0.89862770
85FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89046450
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88734034
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88632435
88FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88525849
89TFEB_21752829_ChIP-Seq_HELA_Human0.88498218
90NFYB_21822215_ChIP-Seq_K562_Human0.88371712
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87555563
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87447869
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86266127
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.86255767
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85481133
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85385560
97GATA6_21074721_ChIP-Seq_CACO-2_Human0.84103083
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83851471
99UTX_26944678_Chip-Seq_JUKART_Human0.83330633
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82977650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation6.82191869
2MP0003806_abnormal_nucleotide_metabolis4.64416741
3MP0000372_irregular_coat_pigmentation4.03160624
4MP0004381_abnormal_hair_follicle3.80285087
5MP0000015_abnormal_ear_pigmentation3.76275108
6MP0005075_abnormal_melanosome_morpholog3.64412793
7MP0005408_hypopigmentation3.41052497
8MP0001986_abnormal_taste_sensitivity2.74148908
9MP0008057_abnormal_DNA_replication2.48071050
10MP0000569_abnormal_digit_pigmentation2.46807255
11MP0005174_abnormal_tail_pigmentation2.40412377
12MP0005410_abnormal_fertilization2.36138483
13MP0005377_hearing/vestibular/ear_phenot2.35593020
14MP0003878_abnormal_ear_physiology2.35593020
15MP0000371_diluted_coat_color2.11476499
16MP0003950_abnormal_plasma_membrane1.98306879
17MP0002396_abnormal_hematopoietic_system1.90336488
18MP0009697_abnormal_copulation1.89843068
19MP0003763_abnormal_thymus_physiology1.84306106
20MP0008995_early_reproductive_senescence1.75436274
21MP0001324_abnormal_eye_pigmentation1.69240151
22MP0002009_preneoplasia1.67656464
23MP0003111_abnormal_nucleus_morphology1.66779898
24MP0003724_increased_susceptibility_to1.66083645
25MP0003136_yellow_coat_color1.64293640
26MP0005167_abnormal_blood-brain_barrier1.58123716
27MP0003656_abnormal_erythrocyte_physiolo1.55656505
28MP0003786_premature_aging1.53128572
29MP0002075_abnormal_coat/hair_pigmentati1.50949296
30MP0002166_altered_tumor_susceptibility1.50832879
31MP0008260_abnormal_autophagy1.49403183
32MP0002095_abnormal_skin_pigmentation1.48737688
33MP0003186_abnormal_redox_activity1.40763529
34MP0001873_stomach_inflammation1.38710405
35MP0001186_pigmentation_phenotype1.37418311
36MP0003172_abnormal_lysosome_physiology1.36802950
37MP0001835_abnormal_antigen_presentation1.25986737
38MP0001929_abnormal_gametogenesis1.24085237
39MP0003077_abnormal_cell_cycle1.22308614
40MP0005645_abnormal_hypothalamus_physiol1.17050545
41MP0010094_abnormal_chromosome_stability1.15958485
42MP0003693_abnormal_embryo_hatching1.12642260
43MP0000566_synostosis1.11646354
44MP0005083_abnormal_biliary_tract1.09068699
45MP0002282_abnormal_trachea_morphology1.05720388
46MP0000465_gastrointestinal_hemorrhage1.04600607
47MP0003718_maternal_effect1.01693341
48MP0003698_abnormal_male_reproductive1.00119646
49MP0002398_abnormal_bone_marrow1.00048666
50MP0009333_abnormal_splenocyte_physiolog0.99575086
51MP0008877_abnormal_DNA_methylation0.98541366
52MP0001853_heart_inflammation0.98222375
53MP0006036_abnormal_mitochondrial_physio0.96219943
54MP0010307_abnormal_tumor_latency0.94823609
55MP0002938_white_spotting0.93636602
56MP0004957_abnormal_blastocyst_morpholog0.91148401
57MP0001800_abnormal_humoral_immune0.91055632
58MP0008058_abnormal_DNA_repair0.90207299
59MP0002019_abnormal_tumor_incidence0.89977163
60MP0000689_abnormal_spleen_morphology0.88708414
61MP0004134_abnormal_chest_morphology0.88684750
62MP0000427_abnormal_hair_cycle0.88529749
63MP0002420_abnormal_adaptive_immunity0.86790806
64MP0006035_abnormal_mitochondrial_morpho0.85495402
65MP0005671_abnormal_response_to0.84535124
66MP0001819_abnormal_immune_cell0.83637051
67MP0002006_tumorigenesis0.82638208
68MP0005423_abnormal_somatic_nervous0.79368393
69MP0004147_increased_porphyrin_level0.79079412
70MP0002210_abnormal_sex_determination0.76678387
71MP0001545_abnormal_hematopoietic_system0.75784480
72MP0005397_hematopoietic_system_phenotyp0.75784480
73MP0000703_abnormal_thymus_morphology0.75735856
74MP0000716_abnormal_immune_system0.75445020
75MP0002098_abnormal_vibrissa_morphology0.74612339
76MP0005248_abnormal_Harderian_gland0.74257018
77MP0002452_abnormal_antigen_presenting0.73344596
78MP0002722_abnormal_immune_system0.71740890
79MP0003195_calcinosis0.71109464
80MP0000383_abnormal_hair_follicle0.70851095
81MP0003943_abnormal_hepatobiliary_system0.69968985
82MP0001348_abnormal_lacrimal_gland0.69934750
83MP0003279_aneurysm0.69800606
84MP0004808_abnormal_hematopoietic_stem0.67586483
85MP0001879_abnormal_lymphatic_vessel0.67071793
86MP0002429_abnormal_blood_cell0.66357804
87MP0002419_abnormal_innate_immunity0.65072676
88MP0002723_abnormal_immune_serum0.64832608
89MP0010678_abnormal_skin_adnexa0.64634630
90MP0000367_abnormal_coat/_hair0.63891252
91MP0003646_muscle_fatigue0.63438986
92MP0001191_abnormal_skin_condition0.62000414
93MP0010234_abnormal_vibrissa_follicle0.61953079
94MP0009278_abnormal_bone_marrow0.61119231
95MP0005387_immune_system_phenotype0.59213860
96MP0001790_abnormal_immune_system0.59213860
97MP0002877_abnormal_melanocyte_morpholog0.58401134
98MP0005000_abnormal_immune_tolerance0.57453257
99MP0008775_abnormal_heart_ventricle0.55816101
100MP0005395_other_phenotype0.55353307

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous abortion (HP:0005268)4.37332878
2Elevated erythrocyte sedimentation rate (HP:0003565)4.31328084
3Chronic sinusitis (HP:0011109)4.26483422
4Abnormality of the nasal septum (HP:0000419)3.90670575
5Deep philtrum (HP:0002002)3.66455578
6Bell-shaped thorax (HP:0001591)3.64673131
7Ocular albinism (HP:0001107)3.51806158
8Abnormality of macular pigmentation (HP:0008002)3.50065993
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.09159024
10Prolonged neonatal jaundice (HP:0006579)3.03676570
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.02350197
12Fatigue (HP:0012378)3.00585942
13Congenital, generalized hypertrichosis (HP:0004540)2.93110343
14Patchy hypopigmentation of hair (HP:0011365)2.90592358
15Submucous cleft hard palate (HP:0000176)2.88405837
16Bony spicule pigmentary retinopathy (HP:0007737)2.82534552
17Premature graying of hair (HP:0002216)2.74884018
183-Methylglutaconic aciduria (HP:0003535)2.72241829
19Abnormality of the epiphyses of the hand (HP:0005924)2.70399808
20Abnormality of the anterior horn cell (HP:0006802)2.69036779
21Degeneration of anterior horn cells (HP:0002398)2.69036779
22Iris hypopigmentation (HP:0007730)2.68911798
23Lip pit (HP:0100267)2.63145116
24Aplasia/Hypoplasia of the macula (HP:0008059)2.62037001
25Congenital sensorineural hearing impairment (HP:0008527)2.59982064
26Attenuation of retinal blood vessels (HP:0007843)2.57521572
27Abnormality of nail color (HP:0100643)2.56867869
28Dyschromatopsia (HP:0007641)2.55898216
29Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.54751626
30Concave nail (HP:0001598)2.53244560
31Stomatitis (HP:0010280)2.52369389
32Abnormality of chromosome segregation (HP:0002916)2.48358762
33White forelock (HP:0002211)2.46195069
34Abnormal auditory evoked potentials (HP:0006958)2.46002337
35Tongue fasciculations (HP:0001308)2.44587189
36Albinism (HP:0001022)2.42511786
37Sensory axonal neuropathy (HP:0003390)2.39477252
38Hypoplasia of the thymus (HP:0000778)2.37216797
39Aplasia/Hypoplasia affecting the retina (HP:0008061)2.35828269
40Severe visual impairment (HP:0001141)2.30194507
41Muscle fibrillation (HP:0010546)2.29347998
42Resting tremor (HP:0002322)2.27417403
43Underdeveloped nasal alae (HP:0000430)2.25671209
44Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.24395581
45Absent epiphyses (HP:0010577)2.24395581
46Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.22916980
47Gastrointestinal infarctions (HP:0005244)2.20664433
48Spinal muscular atrophy (HP:0007269)2.20513574
49Pheochromocytoma (HP:0002666)2.18788232
50Abnormality of T cell number (HP:0011839)2.17845193
51Clitoromegaly (HP:0000057)2.16545883
52Choroideremia (HP:0001139)2.15760532
53Recurrent bronchitis (HP:0002837)2.15201862
54Panhypogammaglobulinemia (HP:0003139)2.13300219
55Oligodactyly (hands) (HP:0001180)2.10898861
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.10427276
57Hypoplasia of the fovea (HP:0007750)2.10427276
58Blue irides (HP:0000635)2.10029529
59Freckling (HP:0001480)2.08117401
60Generalized hypopigmentation of hair (HP:0011358)2.08105742
61Midline defect of the nose (HP:0004122)2.06394899
62T lymphocytopenia (HP:0005403)2.06240040
63Short thumb (HP:0009778)2.06188454
64Abnormality of the parathyroid morphology (HP:0011766)2.06128138
65Abnormality of alanine metabolism (HP:0010916)2.05308390
66Hyperalaninemia (HP:0003348)2.05308390
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05308390
68Hypoplasia of the pons (HP:0012110)2.04201219
69Microvesicular hepatic steatosis (HP:0001414)2.02603207
70Aplasia/Hypoplasia of the earlobes (HP:0009906)2.02422994
71Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01012091
72Ragged-red muscle fibers (HP:0003200)1.98864519
73Abnormal respiratory motile cilium physiology (HP:0012261)1.97302921
74Genetic anticipation (HP:0003743)1.96819427
75Cone-rod dystrophy (HP:0000548)1.95733246
76Respiratory difficulties (HP:0002880)1.95581642
77Aqueductal stenosis (HP:0002410)1.95535908
78Median cleft lip (HP:0000161)1.92867086
79Mitral stenosis (HP:0001718)1.92189556
80Renal Fanconi syndrome (HP:0001994)1.92031812
81Rhinitis (HP:0012384)1.88336679
82Progressive visual loss (HP:0000529)1.88311577
83Metaphyseal dysplasia (HP:0100255)1.85789133
84Insulin-resistant diabetes mellitus (HP:0000831)1.85329443
85Prominent nose (HP:0000448)1.84266370
86Abnormality of eosinophils (HP:0001879)1.79370907
87Decreased central vision (HP:0007663)1.79254868
88Exertional dyspnea (HP:0002875)1.79146074
89Hepatocellular necrosis (HP:0001404)1.78614495
90Volvulus (HP:0002580)1.78533837
91Increased serum lactate (HP:0002151)1.77817384
92Central scotoma (HP:0000603)1.77369578
93Long clavicles (HP:0000890)1.77243040
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76358685
95Abnormal cartilage morphology (HP:0002763)1.76204914
96Slow saccadic eye movements (HP:0000514)1.75706640
97Pulmonary artery stenosis (HP:0004415)1.72183138
98Abnormality of T cells (HP:0002843)1.71994204
99Chromsome breakage (HP:0040012)1.70312730
100Increased hepatocellular lipid droplets (HP:0006565)1.69952268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.02881760
2SCYL24.41061159
3AKT33.83551333
4WEE12.82341434
5CCNB12.72985657
6TEC2.59397159
7BRSK22.13476318
8FRK2.02975478
9BMPR1B2.01856832
10TLK12.00198248
11PDK21.98497341
12MST41.89666962
13PLK41.85067701
14PLK21.81034364
15STK38L1.61930828
16PIK3CG1.60420527
17GRK61.51531008
18MST1R1.50659322
19EPHA21.48884029
20CAMK1G1.33173058
21FES1.21273444
22FER1.18777856
23TGFBR21.18469528
24PNCK1.18119729
25BMPR21.17110307
26PTK2B1.16395747
27BLK1.13992566
28ACVR1B1.13774332
29TAF11.12676458
30NEK61.10358354
31MAP3K21.09689723
32STK31.09405149
33TRPM71.07794939
34SIK31.06232531
35GRK11.05424052
36NME10.98757540
37MELK0.97010532
38NEK90.96507715
39NUAK10.94364030
40STK100.90849271
41MAP2K30.90768715
42NLK0.90582025
43CAMK1D0.89208358
44MAPKAPK30.88257865
45CSNK1A1L0.88088065
46ITK0.85665635
47CDK70.85249377
48ERBB30.84152920
49MKNK20.84010095
50STK40.83845413
51INSRR0.81603059
52ZAP700.78527160
53DDR20.75695214
54BTK0.75310374
55FGFR20.75265917
56PRKAA20.75144484
57JAK30.74207086
58MARK30.73894605
59CSNK1G10.72801627
60CSNK1G30.72277031
61VRK10.71723627
62TYK20.71511026
63CSK0.70504010
64STK380.67289274
65SMG10.66650781
66SGK20.65415184
67BRSK10.65151311
68BUB10.64224758
69CDK120.62329214
70FGR0.61524000
71TRIM280.60833249
72CAMKK20.60298743
73DYRK30.59272114
74CDK80.59202493
75TAOK30.58910596
76PRKCH0.57759984
77HCK0.57431569
78EGFR0.57343147
79BRD40.57005591
80NEK20.52195054
81MAP4K10.51970914
82MET0.50784906
83ZAK0.50523869
84JAK10.50517045
85RPS6KB20.49655004
86PRKCI0.48368377
87MARK20.46887050
88SYK0.46717233
89CSF1R0.44313999
90CDC70.41931187
91PLK30.40999783
92TXK0.40719085
93IRAK40.40240795
94CLK10.38965456
95LCK0.38150034
96MAPK150.37496258
97MAPKAPK50.37337166
98PIM10.36924125
99PAK40.36813294
100CSNK1G20.36661101

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.99096080
2Taste transduction_Homo sapiens_hsa047423.23726719
3Proteasome_Homo sapiens_hsa030503.20091696
4RNA polymerase_Homo sapiens_hsa030203.09119657
5Other glycan degradation_Homo sapiens_hsa005112.63426622
6Primary immunodeficiency_Homo sapiens_hsa053402.59385385
7Homologous recombination_Homo sapiens_hsa034402.31296912
8ABC transporters_Homo sapiens_hsa020102.00199041
9Fanconi anemia pathway_Homo sapiens_hsa034601.92243740
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89939120
11N-Glycan biosynthesis_Homo sapiens_hsa005101.79948454
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.75318980
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.71277238
14RNA transport_Homo sapiens_hsa030131.69997547
15Inositol phosphate metabolism_Homo sapiens_hsa005621.66006008
16Thyroid cancer_Homo sapiens_hsa052161.60374076
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51400516
18Cell cycle_Homo sapiens_hsa041101.50877102
19Systemic lupus erythematosus_Homo sapiens_hsa053221.50705738
20Selenocompound metabolism_Homo sapiens_hsa004501.50479998
21Mismatch repair_Homo sapiens_hsa034301.49953488
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.49148070
23Circadian rhythm_Homo sapiens_hsa047101.47730621
24Sulfur relay system_Homo sapiens_hsa041221.45314364
25Oocyte meiosis_Homo sapiens_hsa041141.42675781
26Basal transcription factors_Homo sapiens_hsa030221.42658168
27Vitamin digestion and absorption_Homo sapiens_hsa049771.40873894
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.29742453
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25802445
30One carbon pool by folate_Homo sapiens_hsa006701.25227724
31Pyrimidine metabolism_Homo sapiens_hsa002401.24045148
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22354876
33RNA degradation_Homo sapiens_hsa030181.19187949
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18322286
35Fatty acid biosynthesis_Homo sapiens_hsa000611.17064575
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13465210
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12564155
38Prostate cancer_Homo sapiens_hsa052151.11238410
39Sphingolipid metabolism_Homo sapiens_hsa006001.09520005
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07862312
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05060771
42Viral carcinogenesis_Homo sapiens_hsa052031.02277474
43Huntingtons disease_Homo sapiens_hsa050160.99373695
44Non-small cell lung cancer_Homo sapiens_hsa052230.98093312
45T cell receptor signaling pathway_Homo sapiens_hsa046600.96692921
46FoxO signaling pathway_Homo sapiens_hsa040680.91840376
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.88502384
48Measles_Homo sapiens_hsa051620.88309196
49Non-homologous end-joining_Homo sapiens_hsa034500.87405554
50Vitamin B6 metabolism_Homo sapiens_hsa007500.86888724
51DNA replication_Homo sapiens_hsa030300.86432279
52Colorectal cancer_Homo sapiens_hsa052100.86274243
53Purine metabolism_Homo sapiens_hsa002300.85314278
54Lysosome_Homo sapiens_hsa041420.84634409
55Peroxisome_Homo sapiens_hsa041460.83634029
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78176544
57p53 signaling pathway_Homo sapiens_hsa041150.78013101
58Autoimmune thyroid disease_Homo sapiens_hsa053200.77327494
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77070705
60Hepatitis B_Homo sapiens_hsa051610.75552214
61Fatty acid elongation_Homo sapiens_hsa000620.73753306
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.70841815
63Fatty acid metabolism_Homo sapiens_hsa012120.70775158
64Lysine degradation_Homo sapiens_hsa003100.70760455
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67256082
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64550211
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63895582
68Glycerolipid metabolism_Homo sapiens_hsa005610.63196786
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57648091
70Allograft rejection_Homo sapiens_hsa053300.56635761
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55475327
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55079048
73Small cell lung cancer_Homo sapiens_hsa052220.54751882
74Herpes simplex infection_Homo sapiens_hsa051680.53967178
75Nucleotide excision repair_Homo sapiens_hsa034200.53095200
76Regulation of autophagy_Homo sapiens_hsa041400.52960638
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52836819
78Hematopoietic cell lineage_Homo sapiens_hsa046400.51090782
79Epstein-Barr virus infection_Homo sapiens_hsa051690.50277497
80B cell receptor signaling pathway_Homo sapiens_hsa046620.49829534
81Alcoholism_Homo sapiens_hsa050340.47607329
82Toxoplasmosis_Homo sapiens_hsa051450.46790631
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46295379
84cAMP signaling pathway_Homo sapiens_hsa040240.45981846
85HTLV-I infection_Homo sapiens_hsa051660.44528443
86Influenza A_Homo sapiens_hsa051640.43108508
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42280961
88Base excision repair_Homo sapiens_hsa034100.42245399
89Tuberculosis_Homo sapiens_hsa051520.41037928
90Mineral absorption_Homo sapiens_hsa049780.40590024
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37935904
92Tyrosine metabolism_Homo sapiens_hsa003500.37069701
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36626732
94Osteoclast differentiation_Homo sapiens_hsa043800.35422806
95Apoptosis_Homo sapiens_hsa042100.35281912
96Type I diabetes mellitus_Homo sapiens_hsa049400.33776960
97Endometrial cancer_Homo sapiens_hsa052130.33639186
98Asthma_Homo sapiens_hsa053100.32400022
99Serotonergic synapse_Homo sapiens_hsa047260.31558255
100Calcium signaling pathway_Homo sapiens_hsa040200.30819969

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