SEC14L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.64097651
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.64097651
3modulation by symbiont of host immune response (GO:0052553)5.64097651
4positive regulation by symbiont of host defense response (GO:0052509)5.64097651
5modulation by symbiont of host defense response (GO:0052031)5.64097651
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.64097651
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.12358589
8negative regulation of cell killing (GO:0031342)5.12358589
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.04563598
10detection of molecule of bacterial origin (GO:0032490)4.96472777
11synaptic vesicle maturation (GO:0016188)4.78306412
12locomotory exploration behavior (GO:0035641)4.65027414
13positive regulation of gamma-delta T cell activation (GO:0046645)4.59364302
14macrophage activation involved in immune response (GO:0002281)4.55420650
15positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.40517344
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.40348965
17neutrophil activation involved in immune response (GO:0002283)4.33466847
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.19228615
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.15474067
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.12313849
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.12138404
22detection of other organism (GO:0098543)4.11490580
23detection of external biotic stimulus (GO:0098581)4.09341345
24regulation of synapse structural plasticity (GO:0051823)4.07470648
25cellular extravasation (GO:0045123)4.01959790
26regulation of B cell receptor signaling pathway (GO:0050855)4.01653710
27regulation of interferon-beta biosynthetic process (GO:0045357)3.99815009
28response to peptidoglycan (GO:0032494)3.96127098
29antigen processing and presentation of endogenous antigen (GO:0019883)3.96060856
30sodium ion export (GO:0071436)3.85491041
31response to host immune response (GO:0052572)3.84370562
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.84370562
33macrophage activation (GO:0042116)3.77545392
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.75439686
35response to host (GO:0075136)3.75439686
36response to host defenses (GO:0052200)3.75439686
37microglial cell activation (GO:0001774)3.75419685
38vocalization behavior (GO:0071625)3.74289969
39layer formation in cerebral cortex (GO:0021819)3.72881083
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70427702
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.66167758
42neutrophil activation (GO:0042119)3.64082152
43detection of bacterium (GO:0016045)3.61638768
44negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.60310404
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.56866593
46cellular potassium ion homeostasis (GO:0030007)3.55673910
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.55305787
48detection of biotic stimulus (GO:0009595)3.53025589
49negative regulation of interleukin-12 production (GO:0032695)3.52101864
50leukocyte migration involved in inflammatory response (GO:0002523)3.47544108
51negative regulation of erythrocyte differentiation (GO:0045647)3.46279850
52synaptic vesicle exocytosis (GO:0016079)3.45757720
53regulation of gamma-delta T cell activation (GO:0046643)3.44753765
54regulation of glutamate receptor signaling pathway (GO:1900449)3.44030799
55response to interleukin-15 (GO:0070672)3.43190611
56regulation of mast cell degranulation (GO:0043304)3.37722762
57cell communication by electrical coupling (GO:0010644)3.37037682
58regulation of synaptic vesicle exocytosis (GO:2000300)3.36577212
59positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.36212677
60glutamate secretion (GO:0014047)3.34798334
61positive regulation of synapse maturation (GO:0090129)3.33891025
62granulocyte activation (GO:0036230)3.32019342
63germinal center formation (GO:0002467)3.31699730
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28076280
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26746245
66negative regulation of lymphocyte mediated immunity (GO:0002707)3.26068421
67regulation of long-term neuronal synaptic plasticity (GO:0048169)3.25334784
68activation of protein kinase A activity (GO:0034199)3.22627430
69exploration behavior (GO:0035640)3.22222173
70regulation of neuronal synaptic plasticity (GO:0048168)3.21249472
71regulation of T-helper 2 cell differentiation (GO:0045628)3.16692342
72regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16382939
73response to muramyl dipeptide (GO:0032495)3.16024418
74regulation of leukocyte degranulation (GO:0043300)3.15984647
75neuromuscular process controlling balance (GO:0050885)3.13325591
76dendritic spine morphogenesis (GO:0060997)3.13083283
77neutrophil mediated immunity (GO:0002446)3.12999097
78regulation of gamma-delta T cell differentiation (GO:0045586)3.11692430
79regulation of mast cell activation involved in immune response (GO:0033006)3.08121073
80myeloid cell activation involved in immune response (GO:0002275)3.07130336
81B cell receptor signaling pathway (GO:0050853)3.04981668
82leukocyte aggregation (GO:0070486)3.04897570
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.04067774
84regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.02154434
85plasma membrane repair (GO:0001778)3.00258520
86cellular response to interleukin-15 (GO:0071350)2.99484749
87antigen processing and presentation via MHC class Ib (GO:0002475)2.98198877
88positive regulation of mast cell activation (GO:0033005)2.97597597
89negative regulation of leukocyte mediated immunity (GO:0002704)2.96967852
90production of molecular mediator involved in inflammatory response (GO:0002532)2.96432532
91positive regulation of cellular amide metabolic process (GO:0034250)2.96258147
92positive regulation of receptor recycling (GO:0001921)2.94472468
93regulation of ARF protein signal transduction (GO:0032012)2.93902310
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.93804303
95regulation of synaptic vesicle transport (GO:1902803)2.93152892
96ionotropic glutamate receptor signaling pathway (GO:0035235)2.92939529
97regulation of macrophage cytokine production (GO:0010935)2.92579864
98long-term memory (GO:0007616)2.91983009
99protein localization to synapse (GO:0035418)2.91384461
100negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90564711
101regulation of dendritic spine morphogenesis (GO:0061001)2.90025467
102respiratory burst (GO:0045730)2.89058140
103stress fiber assembly (GO:0043149)2.88164341
104establishment of nucleus localization (GO:0040023)2.87187906
105lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84979142
106regulation of clathrin-mediated endocytosis (GO:2000369)2.81124073
107synaptic transmission, glutamatergic (GO:0035249)2.76723250
108prepulse inhibition (GO:0060134)2.76675465
109regulation of regulated secretory pathway (GO:1903305)2.76597543
110potassium ion import (GO:0010107)2.75302720
111negative regulation of toll-like receptor signaling pathway (GO:0034122)2.74539446
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.73987944
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.73318358
114neurotransmitter-gated ion channel clustering (GO:0072578)2.72944503
115neurotransmitter secretion (GO:0007269)2.71258214
116regulation of mast cell activation (GO:0033003)2.70167669
117dendritic spine organization (GO:0097061)2.68549289
118negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68334701
119negative regulation of T-helper cell differentiation (GO:0045623)2.68334701
120regulation of necroptotic process (GO:0060544)2.66786833
121proline transport (GO:0015824)2.66651682
122cell communication involved in cardiac conduction (GO:0086065)2.66533060
123regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66070597
124positive regulation of macrophage cytokine production (GO:0060907)2.65026898
125regulation of ARF GTPase activity (GO:0032312)2.62431722
126synaptic vesicle endocytosis (GO:0048488)2.61845768
127membrane repolarization (GO:0086009)2.61251032
128regulation of synaptic plasticity (GO:0048167)2.60937765
129positive regulation of mast cell degranulation (GO:0043306)2.60160678
130positive regulation of mast cell activation involved in immune response (GO:0033008)2.60160678
131myeloid leukocyte mediated immunity (GO:0002444)2.59986745
132regulation of amyloid precursor protein catabolic process (GO:1902991)2.59673797
133regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.59291145
134regulation of postsynaptic membrane potential (GO:0060078)2.59268533
135neuron-neuron synaptic transmission (GO:0007270)2.58807046
136dendrite morphogenesis (GO:0048813)2.58003864
137regulation of platelet aggregation (GO:0090330)2.57009659
138potassium ion homeostasis (GO:0055075)2.56861158
139auditory behavior (GO:0031223)2.56064851
140endothelium development (GO:0003158)2.55654351
141myeloid leukocyte activation (GO:0002274)2.55494778
142cAMP biosynthetic process (GO:0006171)2.55295683
143signal complex assembly (GO:0007172)2.54670350
144vesicle transport along microtubule (GO:0047496)2.54545847
145immunoglobulin mediated immune response (GO:0016064)2.54512312
146regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.54426246
147positive thymic T cell selection (GO:0045059)2.54042246
148negative regulation of T cell mediated immunity (GO:0002710)2.53566217
149glutamate receptor signaling pathway (GO:0007215)2.53045037
150positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.52649599
151response to auditory stimulus (GO:0010996)2.52223357
152membrane depolarization during action potential (GO:0086010)2.51666544
153membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.50487962
154positive regulation of membrane potential (GO:0045838)2.50281575
155positive regulation of Cdc42 GTPase activity (GO:0043089)2.48278494
156dopamine receptor signaling pathway (GO:0007212)2.47348993
157positive regulation of toll-like receptor signaling pathway (GO:0034123)2.47090491
158cellular sodium ion homeostasis (GO:0006883)2.45998000
159neutrophil chemotaxis (GO:0030593)2.45124774
160regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.45090966
161leukocyte degranulation (GO:0043299)2.44917479
162innervation (GO:0060384)2.44686752
163cellular response to type I interferon (GO:0071357)2.44524586
164type I interferon signaling pathway (GO:0060337)2.44524586
165protein localization to endosome (GO:0036010)2.44281466
166regulation of membrane repolarization (GO:0060306)2.44079169
167positive regulation of interferon-alpha production (GO:0032727)2.43782144
168positive regulation of Rap GTPase activity (GO:0032854)2.43128311
169response to type I interferon (GO:0034340)2.43001188
170dendritic cell migration (GO:0036336)2.42505688
171regulation of tolerance induction (GO:0002643)2.42345055
172positive regulation of fibroblast migration (GO:0010763)2.41006952
173regulation of B cell differentiation (GO:0045577)2.40897802
174long-term synaptic potentiation (GO:0060291)2.39599121
175regulation of synapse maturation (GO:0090128)2.39449064
176negative regulation of type 2 immune response (GO:0002829)2.39174955
177positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.39093100
178regulation of voltage-gated calcium channel activity (GO:1901385)2.38781396
179nerve growth factor signaling pathway (GO:0038180)2.38413112
180long term synaptic depression (GO:0060292)2.37364666
181mating behavior (GO:0007617)2.35738951
182cerebellar Purkinje cell layer development (GO:0021680)2.33710214
183adenosine receptor signaling pathway (GO:0001973)2.33604119
184negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.33373535
185cerebellar Purkinje cell differentiation (GO:0021702)2.32288801
186membrane repolarization during action potential (GO:0086011)2.32218394
187protein targeting to plasma membrane (GO:0072661)2.31878507
188regulation of synaptic transmission, glutamatergic (GO:0051966)2.30135076
189negative regulation of potassium ion transmembrane transport (GO:1901380)2.30079033
190neuronal ion channel clustering (GO:0045161)2.29124646
191regulation of Rap GTPase activity (GO:0032317)2.28915515
192membrane depolarization (GO:0051899)2.28413318
193regulation of dendritic spine development (GO:0060998)2.28355433
194positive regulation of vesicle fusion (GO:0031340)2.28087959
195neuronal action potential propagation (GO:0019227)2.27165742
196neuromuscular process (GO:0050905)2.26496730
197positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.26473976
198clathrin coat assembly (GO:0048268)2.23263650
199regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.22656226

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.88513702
2EZH2_22144423_ChIP-Seq_EOC_Human3.61670513
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.16617781
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.09158127
5* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.07887454
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.98244364
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79144018
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.63622007
9* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59935825
10* RARB_27405468_Chip-Seq_BRAIN_Mouse2.57555738
11* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56294492
12DROSHA_22980978_ChIP-Seq_HELA_Human2.55977019
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.55009966
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47196431
15SPI1_23127762_ChIP-Seq_K562_Human2.41613970
16RUNX_20019798_ChIP-Seq_JUKART_Human2.38356694
17SCL_19346495_ChIP-Seq_HPC-7_Human2.22742475
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22670817
19VDR_24763502_ChIP-Seq_THP-1_Human2.19179917
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.19024487
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16538319
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16423997
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16423997
24VDR_21846776_ChIP-Seq_THP-1_Human2.14394439
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.14064800
26GATA2_21666600_ChIP-Seq_HMVEC_Human2.06883529
27* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04607570
28MYC_22102868_ChIP-Seq_BL_Human2.03268537
29MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00961493
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98902048
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98781299
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96712437
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96473944
34* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95993645
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94820468
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93507752
37* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91913793
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91512099
39* KDM2B_26808549_Chip-Seq_K562_Human1.90365180
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88911172
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.88773548
42MAF_26560356_Chip-Seq_TH1_Human1.88298556
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.87695274
44* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.87484388
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87035217
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86859514
47* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86455887
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82577154
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.82360834
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81764424
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81105676
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.80656773
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.78923967
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77426125
55* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.70629928
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69532154
57* REST_21632747_ChIP-Seq_MESCs_Mouse1.69518554
58* SPI1_23547873_ChIP-Seq_NB4_Human1.67445946
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67074641
60VDR_24787735_ChIP-Seq_THP-1_Human1.66990797
61* GATA1_19941826_ChIP-Seq_K562_Human1.65412995
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65237367
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62816795
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.62661599
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.61613061
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.60858102
67UTX_26944678_Chip-Seq_JUKART_Human1.60784482
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55722540
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54303477
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53087966
71GBX2_23144817_ChIP-Seq_PC3_Human1.52161984
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51130101
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50342104
74* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.50040344
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47764923
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46146892
77* MYB_26560356_Chip-Seq_TH2_Human1.45876036
78* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45813495
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.45192396
80* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44436759
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42196146
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42022568
83* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41840163
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41507631
85KDM2B_26808549_Chip-Seq_DND41_Human1.41446476
86* REST_18959480_ChIP-ChIP_MESCs_Mouse1.39050649
87MYB_26560356_Chip-Seq_TH1_Human1.37729702
88* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37581698
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36672685
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36416629
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34870202
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.33219927
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32384808
94* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31800945
95LXR_22292898_ChIP-Seq_THP-1_Human1.29704573
96* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28975037
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.28177378
98* GATA2_19941826_ChIP-Seq_K562_Human1.26071431
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25598037
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25105219
101MAF_26560356_Chip-Seq_TH2_Human1.25055534
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.24565901
103AHR_22903824_ChIP-Seq_MCF-7_Human1.24521107
104PU_27001747_Chip-Seq_BMDM_Mouse1.22141595
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19168095
106GATA1_22025678_ChIP-Seq_K562_Human1.19059545
107* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18990965
108ZNF263_19887448_ChIP-Seq_K562_Human1.18881771
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17527295
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.17303301
111KDM2B_26808549_Chip-Seq_JURKAT_Human1.17193778
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.16872519
113TRIM28_21343339_ChIP-Seq_HEK293_Human1.15125847
114RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14515009
115* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13130916
116* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12453280
117AR_19668381_ChIP-Seq_PC3_Human1.12170061
118SMAD3_21741376_ChIP-Seq_HESCs_Human1.11987812
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11784131
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.10786563
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10335958
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10072934
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09273982
124GATA3_27048872_Chip-Seq_THYMUS_Human1.07939027
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06991654
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05849618
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05538388
128AR_21572438_ChIP-Seq_LNCaP_Human1.02588662
129ZNF274_21170338_ChIP-Seq_K562_Hela1.01222448
130SMC4_20622854_ChIP-Seq_HELA_Human1.00830511
131FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00718645
132NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00065360
133CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99083539
134* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98966998
135CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98902124
136* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98898848
137PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98749375
138CTCF_27219007_Chip-Seq_Bcells_Human0.98594110
139CREB1_26743006_Chip-Seq_LNCaP_Human0.98427647
140KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98125050
141* TBX20_22328084_ChIP-Seq_HEART_Mouse0.97075237
142* TBX20_22080862_ChIP-Seq_HEART_Mouse0.97075237
143RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96945459
144TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96849143
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.96631269
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96388324
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96339552
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.96085415
149ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96077528
150NCOR1_26117541_ChIP-Seq_K562_Human0.95345533
151CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95193793
152* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95021559
153* SOX2_21211035_ChIP-Seq_LN229_Gbm0.94557817
154* RUNX1_27514584_Chip-Seq_MCF-7_Human0.94550398
155CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92731072
156* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92326809
157* TP53_23651856_ChIP-Seq_MEFs_Mouse0.92257825
158* ISL1_27105846_Chip-Seq_CPCs_Mouse0.92144689
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.92130039
160KLF4_19829295_ChIP-Seq_ESCs_Human0.91553309
161SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91492895
162CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91017143
163TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89518305
164CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89482619
165* RACK7_27058665_Chip-Seq_MCF-7_Human0.88129505
166TP53_16413492_ChIP-PET_HCT116_Human0.88063820
167SMAD3_21741376_ChIP-Seq_ESCs_Human0.87688524
168CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87329350
169SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87123583
170TCF7_22412390_ChIP-Seq_EML_Mouse0.86104782
171SMAD4_21799915_ChIP-Seq_A2780_Human0.85486543
172* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85477991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.96463818
2MP0003724_increased_susceptibility_to4.77318699
3MP0003303_peritoneal_inflammation4.43459477
4MP0003436_decreased_susceptibility_to3.70780695
5MP0003635_abnormal_synaptic_transmissio3.14737454
6MP0001835_abnormal_antigen_presentation2.98951550
7MP0002822_catalepsy2.80306776
8MP0003828_pulmonary_edema2.74780234
9MP0002419_abnormal_innate_immunity2.66054000
10MP0004270_analgesia2.55042026
11MP0002063_abnormal_learning/memory/cond2.47730681
12MP0008260_abnormal_autophagy2.47484825
13MP0005451_abnormal_body_composition2.45326792
14MP0003191_abnormal_cellular_cholesterol2.45188414
15MP0000685_abnormal_immune_system2.38522574
16MP0002909_abnormal_adrenal_gland2.37616961
17MP0004858_abnormal_nervous_system2.36201071
18MP0009780_abnormal_chondrocyte_physiolo2.33575721
19MP0005000_abnormal_immune_tolerance2.23882573
20MP0005464_abnormal_platelet_physiology2.23264503
21MP0005025_abnormal_response_to2.23111982
22MP0001800_abnormal_humoral_immune2.20869999
23MP0009745_abnormal_behavioral_response2.14783200
24MP0005623_abnormal_meninges_morphology2.13033795
25MP0005387_immune_system_phenotype2.11587016
26MP0001790_abnormal_immune_system2.11587016
27MP0000751_myopathy2.09316569
28MP0002723_abnormal_immune_serum2.05188546
29MP0002064_seizures2.02168693
30MP0001533_abnormal_skeleton_physiology2.02153227
31MP0002420_abnormal_adaptive_immunity2.02008370
32MP0001819_abnormal_immune_cell1.99282070
33MP0002452_abnormal_antigen_presenting1.98070418
34MP0000465_gastrointestinal_hemorrhage1.92875423
35MP0003705_abnormal_hypodermis_morpholog1.92745489
36MP0005671_abnormal_response_to1.90953898
37MP0010234_abnormal_vibrissa_follicle1.90429670
38MP0009046_muscle_twitch1.88184803
39MP0009785_altered_susceptibility_to1.87315884
40MP0003283_abnormal_digestive_organ1.83312127
41MP0003880_abnormal_central_pattern1.82524659
42MP0002572_abnormal_emotion/affect_behav1.74041138
43MP0004233_abnormal_muscle_weight1.73843954
44MP0004084_abnormal_cardiac_muscle1.69433434
45MP0008961_abnormal_basal_metabolism1.67333529
46MP0002405_respiratory_system_inflammati1.67262819
47MP0003763_abnormal_thymus_physiology1.65359046
48MP0002398_abnormal_bone_marrow1.63709403
49MP0005167_abnormal_blood-brain_barrier1.62996217
50MP0006082_CNS_inflammation1.61089771
51MP0004947_skin_inflammation1.60417432
52MP0001486_abnormal_startle_reflex1.60104161
53MP0009278_abnormal_bone_marrow1.56450118
54MP0000716_abnormal_immune_system1.52780431
55MP0002148_abnormal_hypersensitivity_rea1.51835879
56MP0004883_abnormal_blood_vessel1.51557041
57MP0008569_lethality_at_weaning1.51547177
58MP0002132_abnormal_respiratory_system1.50215010
59MP0000569_abnormal_digit_pigmentation1.48062172
60MP0003075_altered_response_to1.47015165
61MP0004885_abnormal_endolymph1.46191723
62MP0004811_abnormal_neuron_physiology1.44330620
63MP0002653_abnormal_ependyma_morphology1.43930992
64MP0002998_abnormal_bone_remodeling1.40810265
65MP0002272_abnormal_nervous_system1.40668766
66MP0000858_altered_metastatic_potential1.39826735
67MP0008438_abnormal_cutaneous_collagen1.38937507
68MP0002332_abnormal_exercise_endurance1.38273066
69MP0001968_abnormal_touch/_nociception1.35479627
70MP0002734_abnormal_mechanical_nocicepti1.35385209
71MP0001958_emphysema1.35364599
72MP0005409_darkened_coat_color1.35218378
73MP0000534_abnormal_ureter_morphology1.33293948
74MP0003690_abnormal_glial_cell1.32388943
75MP0003045_fibrosis1.30803389
76MP0001851_eye_inflammation1.30711606
77MP0001845_abnormal_inflammatory_respons1.29972511
78MP0010155_abnormal_intestine_physiology1.29810817
79MP0000013_abnormal_adipose_tissue1.28963652
80MP0002837_dystrophic_cardiac_calcinosis1.28950501
81MP0004145_abnormal_muscle_electrophysio1.27628774
82MP0005164_abnormal_response_to1.27579060
83MP0002090_abnormal_vision1.27520351
84MP0004381_abnormal_hair_follicle1.26819050
85MP0002722_abnormal_immune_system1.26316783
86MP0004215_abnormal_myocardial_fiber1.25877362
87MP0004036_abnormal_muscle_relaxation1.25073999
88MP0004085_abnormal_heartbeat1.25007460
89MP0002429_abnormal_blood_cell1.24469090
90MP0004130_abnormal_muscle_cell1.24367642
91MP0009764_decreased_sensitivity_to1.23668214
92MP0003656_abnormal_erythrocyte_physiolo1.22124187
93MP0000689_abnormal_spleen_morphology1.20811505
94MP0003329_amyloid_beta_deposits1.19900532
95MP0001879_abnormal_lymphatic_vessel1.17263241
96MP0003633_abnormal_nervous_system1.16029883
97MP0004087_abnormal_muscle_fiber1.15771761
98MP0002396_abnormal_hematopoietic_system1.14089794
99MP0003183_abnormal_peptide_metabolism1.13546480
100MP0004808_abnormal_hematopoietic_stem1.13008234
101MP0001440_abnormal_grooming_behavior1.12967811
102MP0000703_abnormal_thymus_morphology1.12273496
103MP0002234_abnormal_pharynx_morphology1.10840480
104MP0001501_abnormal_sleep_pattern1.08923014
105MP0000767_abnormal_smooth_muscle1.08766674
106MP0000955_abnormal_spinal_cord1.08380248
107MP0000249_abnormal_blood_vessel1.07476059
108MP0008004_abnormal_stomach_pH1.07054684
109MP0000343_altered_response_to1.06653616
110MP0004272_abnormal_basement_membrane1.06622515
111MP0005423_abnormal_somatic_nervous1.06298487
112MP0005397_hematopoietic_system_phenotyp1.06008982
113MP0001545_abnormal_hematopoietic_system1.06008982
114MP0005076_abnormal_cell_differentiation1.05313645
115MP0002184_abnormal_innervation1.05274060
116MP0004510_myositis1.04058509
117MP0001970_abnormal_pain_threshold1.03465037
118MP0002557_abnormal_social/conspecific_i1.03410080
119MP0003866_abnormal_defecation1.03219399
120MP0002882_abnormal_neuron_morphology1.02872689
121MP0002733_abnormal_thermal_nociception1.02411220
122MP0001849_ear_inflammation1.01699391
123MP0004484_altered_response_of1.01275894
124MP0003279_aneurysm1.00701961
125MP0003879_abnormal_hair_cell0.99724409
126MP0000778_abnormal_nervous_system0.99121016
127MP0005275_abnormal_skin_tensile0.98878175
128MP0003566_abnormal_cell_adhesion0.98721641
129MP0009333_abnormal_splenocyte_physiolog0.97636526
130MP0005620_abnormal_muscle_contractility0.97405691
131MP0003172_abnormal_lysosome_physiology0.96934599
132MP0005058_abnormal_lysosome_morphology0.96557308
133MP0002067_abnormal_sensory_capabilities0.95850385
134MP0000749_muscle_degeneration0.95389379
135MP0005166_decreased_susceptibility_to0.94997692
136MP0000003_abnormal_adipose_tissue0.93578446
137MP0008469_abnormal_protein_level0.93261200
138MP0003137_abnormal_impulse_conducting0.92475374
139MP0005310_abnormal_salivary_gland0.92354364
140MP0003448_altered_tumor_morphology0.92337013
141MP0002166_altered_tumor_susceptibility0.92043575
142MP0008874_decreased_physiological_sensi0.91513050
143MP0002736_abnormal_nociception_after0.90953374
144MP0002152_abnormal_brain_morphology0.90626026
145MP0002877_abnormal_melanocyte_morpholog0.90329443
146MP0010368_abnormal_lymphatic_system0.89329503
147MP0005390_skeleton_phenotype0.89242914
148MP0001177_atelectasis0.89203225
149MP0002066_abnormal_motor_capabilities/c0.88545499
150MP0005551_abnormal_eye_electrophysiolog0.88398396
151MP0004185_abnormal_adipocyte_glucose0.87114068
152MP0004924_abnormal_behavior0.87076955
153MP0005386_behavior/neurological_phenoty0.87076955
154MP0003634_abnormal_glial_cell0.86661338
155MP0000747_muscle_weakness0.86608370
156MP0002933_joint_inflammation0.86601121
157MP0002277_abnormal_respiratory_mucosa0.86512870
158MP0003091_abnormal_cell_migration0.86224400
159MP0002972_abnormal_cardiac_muscle0.85725422
160MP0003631_nervous_system_phenotype0.85253060
161MP0000759_abnormal_skeletal_muscle0.85003729
162MP0001299_abnormal_eye_distance/0.83231370
163MP0003221_abnormal_cardiomyocyte_apopto0.82867310
164MP0002133_abnormal_respiratory_system0.82520007
165MP0005388_respiratory_system_phenotype0.82520007
166MP0002735_abnormal_chemical_nociception0.80677868
167MP0003300_gastrointestinal_ulcer0.80654819
168MP0001915_intracranial_hemorrhage0.79606075
169MP0002089_abnormal_postnatal_growth/wei0.78407958
170MP0002269_muscular_atrophy0.78199113
171MP0003787_abnormal_imprinting0.78027226
172MP0000537_abnormal_urethra_morphology0.77366936
173MP0000733_abnormal_muscle_development0.77180256
174MP0005410_abnormal_fertilization0.76991600
175MP0005187_abnormal_penis_morphology0.76688009
176MP0010630_abnormal_cardiac_muscle0.75649447
177MP0000604_amyloidosis0.75378689
178MP0000015_abnormal_ear_pigmentation0.68804730
179MP0001663_abnormal_digestive_system0.67019726
180MP0005023_abnormal_wound_healing0.65120796

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.10263013
2Orchitis (HP:0100796)4.63660864
3Myositis (HP:0100614)4.58186925
4Spontaneous hematomas (HP:0007420)4.55526872
5Recurrent abscess formation (HP:0002722)4.41957024
6Recurrent bacterial skin infections (HP:0005406)4.34211659
7Retrobulbar optic neuritis (HP:0100654)4.32399268
8Optic neuritis (HP:0100653)4.32399268
9Myokymia (HP:0002411)4.09823805
10Abnormality of macrophages (HP:0004311)4.07509961
11Recurrent gram-negative bacterial infections (HP:0005420)3.74001593
12Gastrointestinal infarctions (HP:0005244)3.55931192
13Focal motor seizures (HP:0011153)3.37877300
14Prolonged bleeding time (HP:0003010)3.36535341
15Focal seizures (HP:0007359)3.18248077
16Keratoconjunctivitis sicca (HP:0001097)3.13806783
17Peritonitis (HP:0002586)3.12250022
18Action tremor (HP:0002345)3.06856541
19Visual hallucinations (HP:0002367)3.03648237
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.99468351
21Cerebral aneurysm (HP:0004944)2.99148528
22Obstructive lung disease (HP:0006536)2.94433340
23Chronic obstructive pulmonary disease (HP:0006510)2.94433340
24Elevated erythrocyte sedimentation rate (HP:0003565)2.93375368
25Cellulitis (HP:0100658)2.91683213
26Mediastinal lymphadenopathy (HP:0100721)2.91207565
27Epistaxis (HP:0000421)2.89725457
28Gingivitis (HP:0000230)2.89157944
29Episodic fever (HP:0001954)2.87003444
30Recurrent fungal infections (HP:0002841)2.86864840
31Meningitis (HP:0001287)2.85772363
32Vasculitis (HP:0002633)2.85467417
33Stomatitis (HP:0010280)2.83099126
34Arterial thrombosis (HP:0004420)2.82893252
35Chest pain (HP:0100749)2.81639286
36Gingival bleeding (HP:0000225)2.81360365
37Keratoconjunctivitis (HP:0001096)2.79693466
38Polycythemia (HP:0001901)2.77536450
39Recurrent skin infections (HP:0001581)2.77354478
40Annular pancreas (HP:0001734)2.75330088
41Bundle branch block (HP:0011710)2.73942471
42Increased IgE level (HP:0003212)2.71286617
43Abnormality of the lower motor neuron (HP:0002366)2.69827714
44Upper limb amyotrophy (HP:0009129)2.69670896
45Distal upper limb amyotrophy (HP:0007149)2.69670896
46Shallow orbits (HP:0000586)2.68553541
47Dysmetric saccades (HP:0000641)2.63650470
48Amyloidosis (HP:0011034)2.56712656
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.54887211
50Abnormal platelet volume (HP:0011876)2.54200795
51Encephalitis (HP:0002383)2.51338366
52Urticaria (HP:0001025)2.50995121
53Hemoptysis (HP:0002105)2.48622426
54Menorrhagia (HP:0000132)2.42077449
55Pulmonary embolism (HP:0002204)2.41500307
56Epileptic encephalopathy (HP:0200134)2.39532850
57Pointed chin (HP:0000307)2.38954868
58Subacute progressive viral hepatitis (HP:0006572)2.37243579
59Depression (HP:0000716)2.37137914
60Chronic mucocutaneous candidiasis (HP:0002728)2.36872977
61Recurrent cutaneous fungal infections (HP:0011370)2.36872977
62Hypochromic microcytic anemia (HP:0004840)2.34298616
63Abnormality of the peritoneum (HP:0002585)2.33202090
64Broad metatarsal (HP:0001783)2.32483059
65Ventricular fibrillation (HP:0001663)2.31596583
66Sudden death (HP:0001699)2.31331059
67Pulmonary infiltrates (HP:0002113)2.30752799
68Hemiplegia (HP:0002301)2.29478851
69Supranuclear gaze palsy (HP:0000605)2.27173799
70Prolonged QT interval (HP:0001657)2.25169988
71Resting tremor (HP:0002322)2.23131626
72Osteomyelitis (HP:0002754)2.23086022
73Hand muscle atrophy (HP:0009130)2.22949120
74Hemorrhage of the eye (HP:0011885)2.22054942
75Muscle fiber splitting (HP:0003555)2.17430393
76Slow saccadic eye movements (HP:0000514)2.17207701
77Dysdiadochokinesis (HP:0002075)2.17112860
78Microcytic anemia (HP:0001935)2.16863797
79Hypochromic anemia (HP:0001931)2.16027196
80Progressive cerebellar ataxia (HP:0002073)2.15815592
81Neoplasm of the heart (HP:0100544)2.13450442
82T lymphocytopenia (HP:0005403)2.12968400
83Hyperacusis (HP:0010780)2.11959362
84Ankyloglossia (HP:0010296)2.11812340
85Postural instability (HP:0002172)2.10945693
86Genetic anticipation (HP:0003743)2.10206111
87Segmental peripheral demyelination/remyelination (HP:0003481)2.09736518
88Lower limb amyotrophy (HP:0007210)2.09172179
89Myocardial infarction (HP:0001658)2.08132993
90Insomnia (HP:0100785)2.07886559
91Rapidly progressive (HP:0003678)2.07627173
92Ankle clonus (HP:0011448)2.06786022
93Bronchomalacia (HP:0002780)2.06589355
94Increased variability in muscle fiber diameter (HP:0003557)2.05937225
95Abnormality of the endocardium (HP:0004306)2.04569178
96Poor eye contact (HP:0000817)2.03735351
97Impaired social interactions (HP:0000735)2.03408610
98Abnormal social behavior (HP:0012433)2.03408610
99Abnormality of T cell number (HP:0011839)2.02649986
100Protrusio acetabuli (HP:0003179)2.00777133
101Atrial fibrillation (HP:0005110)2.00754612
102Difficulty running (HP:0009046)2.00271879
103Impaired smooth pursuit (HP:0007772)1.99528150
104Primary atrial arrhythmia (HP:0001692)1.98351235
105Mutism (HP:0002300)1.97419907
106Atonic seizures (HP:0010819)1.97019342
107Increased mean platelet volume (HP:0011877)1.95795100
108Acne (HP:0001061)1.94852275
109Purpura (HP:0000979)1.94773760
110Inflammation of the large intestine (HP:0002037)1.93955921
111Glomerulopathy (HP:0100820)1.93881380
112Leukocytosis (HP:0001974)1.92857103
113Impaired vibration sensation in the lower limbs (HP:0002166)1.92216185
114Abnormal EKG (HP:0003115)1.92106220
115Gastrointestinal inflammation (HP:0004386)1.91294216
116Vertigo (HP:0002321)1.90891138
117Arterial tortuosity (HP:0005116)1.90825444
118Urinary bladder sphincter dysfunction (HP:0002839)1.90331301
119Petechiae (HP:0000967)1.89892746
120Mildly elevated creatine phosphokinase (HP:0008180)1.89475769
121Hematochezia (HP:0002573)1.89088636
122Cerebral inclusion bodies (HP:0100314)1.88574115
123Anorexia (HP:0002039)1.88333664
124Macroorchidism (HP:0000053)1.88186803
125Viral hepatitis (HP:0006562)1.87423840
126Aneurysm (HP:0002617)1.86830572
127Stereotypic behavior (HP:0000733)1.86529646
128Exercise-induced myalgia (HP:0003738)1.86439151
129Enlarged penis (HP:0000040)1.85820122
130Intention tremor (HP:0002080)1.85739928
131Achilles tendon contracture (HP:0001771)1.84858709
132Difficulty climbing stairs (HP:0003551)1.84714473
133Gaze-evoked nystagmus (HP:0000640)1.83669564
134Recurrent viral infections (HP:0004429)1.83593478
135Abnormality of the fingertips (HP:0001211)1.83042925
136Lower limb asymmetry (HP:0100559)1.82613285
137Supraventricular arrhythmia (HP:0005115)1.82108090
138Gastrointestinal stroma tumor (HP:0100723)1.81975453
139Buphthalmos (HP:0000557)1.81800144
140Hyporeflexia of lower limbs (HP:0002600)1.81756466
141Bladder diverticulum (HP:0000015)1.81251312
142Abnormal platelet function (HP:0011869)1.80033786
143Impaired platelet aggregation (HP:0003540)1.80033786
144Supraventricular tachycardia (HP:0004755)1.79953336
145Torticollis (HP:0000473)1.79572278
146Sepsis (HP:0100806)1.79213681
147Megalencephaly (HP:0001355)1.78712477
148Aortic aneurysm (HP:0004942)1.78685978
149Abnormality of ocular smooth pursuit (HP:0000617)1.78512834
150Vascular tortuosity (HP:0004948)1.77601804
151Abnormality of the nasal mucosa (HP:0000433)1.77509957
152Dilatation of the ascending aorta (HP:0005111)1.77163551
153Syncope (HP:0001279)1.76540467
154Urinary urgency (HP:0000012)1.76106629
155Mitral valve prolapse (HP:0001634)1.74619854
156Interstitial pulmonary disease (HP:0006530)1.74287545
157Astrocytoma (HP:0009592)1.73416629
158Abnormality of the astrocytes (HP:0100707)1.73416629
159Type 1 muscle fiber predominance (HP:0003803)1.72721044
160Abnormality of skeletal muscle fiber size (HP:0012084)1.72594948
161Elfin facies (HP:0004428)1.72506770
162Central scotoma (HP:0000603)1.72013033
163Abnormality of the pleura (HP:0002103)1.71541688
164Exercise-induced muscle cramps (HP:0003710)1.71081789
165Papilledema (HP:0001085)1.71029122
166Bruising susceptibility (HP:0000978)1.70907442
167Fatigue (HP:0012378)1.70903752
168Amblyopia (HP:0000646)1.70890616
169Absence seizures (HP:0002121)1.70779401
170Febrile seizures (HP:0002373)1.70728539
171Generalized tonic-clonic seizures (HP:0002069)1.70564533
172Obstructive sleep apnea (HP:0002870)1.70550953
173Recurrent pneumonia (HP:0006532)1.70129112
174Ankle contracture (HP:0006466)1.69505806
175Dysmetria (HP:0001310)1.69156379
176Scapular winging (HP:0003691)1.68914222
177Metaphyseal cupping (HP:0003021)1.67497946
178Increased connective tissue (HP:0009025)1.67078019
179Aseptic necrosis (HP:0010885)1.66524802
180Abnormality of oral frenula (HP:0000190)1.66394172
181Hemiparesis (HP:0001269)1.66237075
182Genu recurvatum (HP:0002816)1.66016025
183Truncal ataxia (HP:0002078)1.65454831
184Onion bulb formation (HP:0003383)1.65417128
185Hypercortisolism (HP:0001578)1.65364938
186Heart block (HP:0012722)1.64218663
187Skin ulcer (HP:0200042)1.63642627
188Increased IgM level (HP:0003496)1.63581143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.67952857
2EPHA43.56908484
3MAP3K93.24799455
4TRIB32.90160271
5NTRK32.86489656
6MAP2K32.76425553
7IRAK42.66162634
8KSR22.46786977
9EPHB12.46668503
10CSK2.45485327
11BLK2.36614524
12RIPK12.32810048
13MAP4K12.30609947
14DAPK22.28466605
15PAK62.22294144
16CAMKK12.17000318
17TYK22.09567718
18STK381.89776168
19MAP3K31.81483627
20TIE11.78026557
21PKN21.75256156
22ZAP701.70331588
23TYRO31.60698212
24FGR1.57237966
25PDGFRA1.54260540
26MINK11.52968374
27JAK31.52466787
28KSR11.50554057
29NTRK11.46762470
30HCK1.46744292
31MAP3K141.46081031
32LMTK21.44712962
33TAOK11.43279907
34TTN1.43219955
35DDR21.42168955
36MAP3K21.41442008
37GRK61.40944185
38ICK1.38575234
39DMPK1.37464064
40MARK11.37254756
41PTK2B1.34207061
42YES11.32807746
43BTK1.27039397
44MAP3K41.25998467
45TNK21.25935649
46JAK11.24579016
47CAMK1G1.24324190
48NEK11.20739720
49MAP3K111.20464354
50IRAK11.19019126
51JAK21.18227992
52SIK21.17017763
53LATS21.15959187
54CDK121.15809868
55SYK1.15047219
56EEF2K1.13931972
57CDK51.13241954
58IRAK21.11832682
59PRKCH1.10740016
60PDK21.10602305
61FGFR41.08883745
62RET1.07868607
63ALK1.05797588
64PDK41.05278626
65PDK31.05278626
66IKBKE1.05269855
67SMG11.05157569
68PHKG11.04739853
69PHKG21.04739853
70FER1.03483480
71NTRK21.03261180
72SIK31.01727795
73CAMKK21.00051467
74DAPK10.99918214
75RIPK40.99464386
76PRPF4B0.93620687
77TAOK20.93013370
78BMX0.92296298
79PTK60.90535356
80WNK10.88755179
81FGFR30.88417528
82MATK0.88400838
83MAPK120.88349815
84TBK10.87911020
85PDPK10.87674694
86PDK10.86715303
87LYN0.84598157
88SGK30.84263001
89PAK30.83578731
90CAMK1D0.83492630
91PTK20.82456848
92CAMK10.80654020
93LATS10.80241408
94LRRK20.79581877
95TGFBR20.78922638
96MARK20.78506532
97CSF1R0.78265989
98AKT30.77550964
99IRAK30.75906704
100CDC42BPA0.75757166
101ITK0.75486991
102LCK0.73211185
103TAOK30.72849517
104MAP3K70.72365690
105KDR0.72125914
106STK110.71874859
107MAP3K10.70536348
108STK100.70355023
109FES0.69500641
110PRKD20.68868682
111EPHA30.68586561
112MAP3K60.68047113
113MAPK70.65928539
114PAK40.65164816
115PIK3CG0.65145122
116GRK50.64867658
117PDGFRB0.63180045
118CAMK40.62561258
119MARK30.60252202
120CDK150.60234826
121MAP2K40.60015234
122PINK10.59879069
123SCYL20.58786044
124PRKD10.57956014
125CDK180.57892797
126BMPR20.57809395
127NEK60.57290382
128HIPK20.57152963
129CDK140.56346499
130MAP2K10.55480766
131DYRK1B0.55317672
132SGK10.55037317
133TXK0.54875682
134WNK40.54643640
135RAF10.54485136
136SIK10.53410272
137TESK10.52287163
138RPS6KA20.49766425
139ARAF0.49148971
140CDK11A0.48911090
141ERN10.47871211
142KIT0.47251682
143PLK20.47175418
144SGK2230.47157117
145SGK4940.47157117
146PRKCG0.46669950
147MTOR0.45629776
148TEC0.45526641
149FYN0.45319138
150MOS0.44707532
151EPHB20.44508032
152RPS6KA30.44352592
153RPS6KC10.43657870
154RPS6KL10.43657870
155DAPK30.43595499
156NEK90.43207204
157TRPM70.42927251
158SGK20.41491381
159MAP3K130.41355845

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.37469485
2Leishmaniasis_Homo sapiens_hsa051402.21729920
3Olfactory transduction_Homo sapiens_hsa047402.17317154
4Long-term potentiation_Homo sapiens_hsa047202.09035833
5Synaptic vesicle cycle_Homo sapiens_hsa047212.08484351
6Circadian entrainment_Homo sapiens_hsa047132.05787376
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05400513
8B cell receptor signaling pathway_Homo sapiens_hsa046622.05028217
9Salivary secretion_Homo sapiens_hsa049701.82356609
10Nicotine addiction_Homo sapiens_hsa050331.80198167
11Morphine addiction_Homo sapiens_hsa050321.74508458
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73075124
13Glutamatergic synapse_Homo sapiens_hsa047241.72288086
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.72265067
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71963870
16Gastric acid secretion_Homo sapiens_hsa049711.70706840
17Staphylococcus aureus infection_Homo sapiens_hsa051501.69781716
18Amphetamine addiction_Homo sapiens_hsa050311.69411110
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69343537
20GABAergic synapse_Homo sapiens_hsa047271.69272499
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67113785
22Acute myeloid leukemia_Homo sapiens_hsa052211.66836546
23Tuberculosis_Homo sapiens_hsa051521.66314122
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.65264084
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63939325
26Insulin secretion_Homo sapiens_hsa049111.61637237
27Malaria_Homo sapiens_hsa051441.59560687
28Cholinergic synapse_Homo sapiens_hsa047251.57059859
29Oxytocin signaling pathway_Homo sapiens_hsa049211.55803051
30Dopaminergic synapse_Homo sapiens_hsa047281.55554722
31Renin secretion_Homo sapiens_hsa049241.54770429
32Chemokine signaling pathway_Homo sapiens_hsa040621.47787026
33Pancreatic cancer_Homo sapiens_hsa052121.47498063
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.45868302
35Dilated cardiomyopathy_Homo sapiens_hsa054141.41383683
36Measles_Homo sapiens_hsa051621.37869988
37Toxoplasmosis_Homo sapiens_hsa051451.37678944
38T cell receptor signaling pathway_Homo sapiens_hsa046601.35113527
39Glioma_Homo sapiens_hsa052141.33923253
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33892773
41GnRH signaling pathway_Homo sapiens_hsa049121.32403125
42Gap junction_Homo sapiens_hsa045401.31763152
43Notch signaling pathway_Homo sapiens_hsa043301.29107010
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28670792
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28013002
46Estrogen signaling pathway_Homo sapiens_hsa049151.27992900
47Calcium signaling pathway_Homo sapiens_hsa040201.26408683
48Influenza A_Homo sapiens_hsa051641.25249274
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23938939
50Type II diabetes mellitus_Homo sapiens_hsa049301.22302490
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.20719619
52Hepatitis B_Homo sapiens_hsa051611.19891544
53Cocaine addiction_Homo sapiens_hsa050301.19813655
54TNF signaling pathway_Homo sapiens_hsa046681.19304710
55Long-term depression_Homo sapiens_hsa047301.18633185
56cAMP signaling pathway_Homo sapiens_hsa040241.17670466
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14763569
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14648085
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13978448
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13753069
61Jak-STAT signaling pathway_Homo sapiens_hsa046301.12035012
62Prolactin signaling pathway_Homo sapiens_hsa049171.11710030
63mTOR signaling pathway_Homo sapiens_hsa041501.10607725
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09282715
65Phagosome_Homo sapiens_hsa041451.06910532
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05700043
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05549449
68Hepatitis C_Homo sapiens_hsa051601.05426730
69VEGF signaling pathway_Homo sapiens_hsa043701.05304627
70Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04164234
71Dorso-ventral axis formation_Homo sapiens_hsa043201.04039414
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03171255
73Graft-versus-host disease_Homo sapiens_hsa053321.02887854
74Phospholipase D signaling pathway_Homo sapiens_hsa040721.01617267
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00454256
76Melanogenesis_Homo sapiens_hsa049160.99926961
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99869887
78Taste transduction_Homo sapiens_hsa047420.99470474
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.98997411
80Hematopoietic cell lineage_Homo sapiens_hsa046400.98758898
81Apoptosis_Homo sapiens_hsa042100.98363369
82Allograft rejection_Homo sapiens_hsa053300.98156355
83ErbB signaling pathway_Homo sapiens_hsa040120.97384391
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97282453
85Viral myocarditis_Homo sapiens_hsa054160.96973695
86Focal adhesion_Homo sapiens_hsa045100.95385538
87Pancreatic secretion_Homo sapiens_hsa049720.95061959
88Shigellosis_Homo sapiens_hsa051310.93820476
89FoxO signaling pathway_Homo sapiens_hsa040680.93486833
90Axon guidance_Homo sapiens_hsa043600.93056456
91Rap1 signaling pathway_Homo sapiens_hsa040150.92478115
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91922589
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.91863449
94Legionellosis_Homo sapiens_hsa051340.91284591
95Endometrial cancer_Homo sapiens_hsa052130.91280006
96Salmonella infection_Homo sapiens_hsa051320.89036128
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88824218
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88442874
99Serotonergic synapse_Homo sapiens_hsa047260.88141846
100African trypanosomiasis_Homo sapiens_hsa051430.86755475
101Autoimmune thyroid disease_Homo sapiens_hsa053200.86278912
102Phototransduction_Homo sapiens_hsa047440.85467938
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84766509
104Non-small cell lung cancer_Homo sapiens_hsa052230.84582821
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83191790
106Proteoglycans in cancer_Homo sapiens_hsa052050.83058251
107Primary immunodeficiency_Homo sapiens_hsa053400.82613595
108Renal cell carcinoma_Homo sapiens_hsa052110.82267328
109Endocytosis_Homo sapiens_hsa041440.81626779
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80820758
111Thyroid hormone synthesis_Homo sapiens_hsa049180.80463173
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79532588
113Adherens junction_Homo sapiens_hsa045200.79135866
114Pertussis_Homo sapiens_hsa051330.78982801
115Herpes simplex infection_Homo sapiens_hsa051680.78859085
116Choline metabolism in cancer_Homo sapiens_hsa052310.75153968
117Tight junction_Homo sapiens_hsa045300.74955125
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.74790665
119Glucagon signaling pathway_Homo sapiens_hsa049220.74030089
120Prostate cancer_Homo sapiens_hsa052150.74013836
121Oocyte meiosis_Homo sapiens_hsa041140.73766825
122MAPK signaling pathway_Homo sapiens_hsa040100.73540480
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.73154480
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72294203
125Nitrogen metabolism_Homo sapiens_hsa009100.72155462
126Chronic myeloid leukemia_Homo sapiens_hsa052200.71486593
127Amoebiasis_Homo sapiens_hsa051460.70100028
128ECM-receptor interaction_Homo sapiens_hsa045120.69664358
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69542908
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68834347
131Hippo signaling pathway_Homo sapiens_hsa043900.68513053
132Insulin signaling pathway_Homo sapiens_hsa049100.67184950
133Inositol phosphate metabolism_Homo sapiens_hsa005620.67032112
134Antigen processing and presentation_Homo sapiens_hsa046120.65586366
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65507197
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64942746
137Cardiac muscle contraction_Homo sapiens_hsa042600.64857162
138Small cell lung cancer_Homo sapiens_hsa052220.64667630
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64109608
140Platelet activation_Homo sapiens_hsa046110.63181463
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62478993
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.61278268
143Thyroid cancer_Homo sapiens_hsa052160.60426883
144Ras signaling pathway_Homo sapiens_hsa040140.60224825
145HIF-1 signaling pathway_Homo sapiens_hsa040660.59457394
146Bladder cancer_Homo sapiens_hsa052190.59352344
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58509994
148Wnt signaling pathway_Homo sapiens_hsa043100.56819340
149Colorectal cancer_Homo sapiens_hsa052100.56540881
150Type I diabetes mellitus_Homo sapiens_hsa049400.56401194
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56359632
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.55557702
153Protein digestion and absorption_Homo sapiens_hsa049740.54367697
154Insulin resistance_Homo sapiens_hsa049310.50889911
155Collecting duct acid secretion_Homo sapiens_hsa049660.50500086
156Vibrio cholerae infection_Homo sapiens_hsa051100.49485120
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49335491

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