SEC14L1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ketone body metabolic process (GO:1902224)6.40172040
2cellular ketone body metabolic process (GO:0046950)6.17523808
3DNA synthesis involved in DNA repair (GO:0000731)5.27365969
4pyrimidine dimer repair (GO:0006290)5.05746569
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.04660850
6response to UV-C (GO:0010225)4.87747863
7regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.74277533
8regulation of regulatory T cell differentiation (GO:0045589)4.69908633
9synaptonemal complex assembly (GO:0007130)4.43594452
10positive regulation of protein homodimerization activity (GO:0090073)4.39221839
11piRNA metabolic process (GO:0034587)4.30379211
12synaptonemal complex organization (GO:0070193)4.26153814
13positive regulation of T cell differentiation in thymus (GO:0033089)4.26041360
14regulation of memory T cell differentiation (GO:0043380)4.23625212
15platelet dense granule organization (GO:0060155)4.11324360
16L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.99646241
17regulation of sarcomere organization (GO:0060297)3.94738181
18negative regulation of neurotransmitter secretion (GO:0046929)3.89737210
19phenol-containing compound catabolic process (GO:0019336)3.88324680
20tolerance induction (GO:0002507)3.83791471
21cellular response to antibiotic (GO:0071236)3.62764752
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.60585092
23positive regulation of defense response to virus by host (GO:0002230)3.57044838
24DNA deamination (GO:0045006)3.54362528
25regulation of B cell receptor signaling pathway (GO:0050855)3.50693342
26centriole replication (GO:0007099)3.44639066
27L-methionine biosynthetic process (GO:0071265)3.34266447
28amino acid salvage (GO:0043102)3.34266447
29L-methionine salvage (GO:0071267)3.34266447
30definitive hemopoiesis (GO:0060216)3.32702376
31regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.31941714
32positive regulation of vasculogenesis (GO:2001214)3.31649112
33multicellular organism reproduction (GO:0032504)3.28873340
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.24449986
35positive regulation of mRNA catabolic process (GO:0061014)3.20161725
36regulation of T cell receptor signaling pathway (GO:0050856)3.15145201
37negative regulation of interleukin-10 production (GO:0032693)3.13950636
38regulation of cellular senescence (GO:2000772)3.13595338
39negative regulation of mast cell activation (GO:0033004)3.07108172
40methionine biosynthetic process (GO:0009086)3.03254494
41positive regulation of uterine smooth muscle contraction (GO:0070474)3.00297581
42megakaryocyte development (GO:0035855)3.00217459
43meiotic cell cycle (GO:0051321)3.00175608
44negative regulation of neurotransmitter transport (GO:0051589)2.99065914
45regulation of defense response to virus by host (GO:0050691)2.98783383
46monoubiquitinated protein deubiquitination (GO:0035520)2.98075261
47regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.95572464
48histone H3-K9 methylation (GO:0051567)2.94583971
49cellular response to toxic substance (GO:0097237)2.93895594
50chromosome organization involved in meiosis (GO:0070192)2.92954665
51methionine metabolic process (GO:0006555)2.91825072
52phosphatidylethanolamine metabolic process (GO:0046337)2.90031213
53regulation of germinal center formation (GO:0002634)2.88475977
54positive regulation of cardiac muscle cell differentiation (GO:2000727)2.87712020
55phosphorylated carbohydrate dephosphorylation (GO:0046838)2.86802092
56inositol phosphate dephosphorylation (GO:0046855)2.86802092
57regulation of isotype switching to IgG isotypes (GO:0048302)2.84688141
58embryonic hemopoiesis (GO:0035162)2.84480310
59regulation of mRNA catabolic process (GO:0061013)2.82042218
60DNA methylation involved in gamete generation (GO:0043046)2.80659415
61centriole assembly (GO:0098534)2.79943363
62regulation of acrosome reaction (GO:0060046)2.77900853
63B cell receptor signaling pathway (GO:0050853)2.75914201
64positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.75251066
65male meiosis (GO:0007140)2.74437892
66activated T cell proliferation (GO:0050798)2.74090295
67positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.73791524
68regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.73791524
69phosphatidylethanolamine biosynthetic process (GO:0006646)2.73106637
70neuron remodeling (GO:0016322)2.71377287
71translesion synthesis (GO:0019985)2.70567166
72histone H3-K9 modification (GO:0061647)2.69155831
73positive regulation of interleukin-4 production (GO:0032753)2.69048190
74leukocyte aggregation (GO:0070486)2.66522132
75negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.66296127
76DNA biosynthetic process (GO:0071897)2.65596709
77positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.65164148
78regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.65164148
79hormone catabolic process (GO:0042447)2.63952888
80positive regulation of interleukin-17 production (GO:0032740)2.62573839
81positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.62456980
82phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.62231102
83positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.62137455
84neuronal action potential propagation (GO:0019227)2.61175306
85oocyte development (GO:0048599)2.60958088
86protein K11-linked deubiquitination (GO:0035871)2.60608552
87negative thymic T cell selection (GO:0045060)2.59170467
88positive T cell selection (GO:0043368)2.57749892
89melanocyte differentiation (GO:0030318)2.56181893
90regulation of histone H3-K9 methylation (GO:0051570)2.54371344
91interferon-gamma secretion (GO:0072643)2.53914570
92protein K48-linked deubiquitination (GO:0071108)2.53366249
93positive regulation of gamma-delta T cell activation (GO:0046645)2.53138735
94cartilage morphogenesis (GO:0060536)2.53019955
95positive regulation of tolerance induction (GO:0002645)2.52548188
96pigment cell differentiation (GO:0050931)2.49430986
97positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.48123609
98photoreceptor cell maintenance (GO:0045494)2.47780336
99lymphoid progenitor cell differentiation (GO:0002320)2.47469903
100developmental pigmentation (GO:0048066)2.47145028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.42932105
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.80272180
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.77962772
4NOTCH1_21737748_ChIP-Seq_TLL_Human3.52648211
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.18303048
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.58489142
7VDR_22108803_ChIP-Seq_LS180_Human2.55946639
8GATA1_22025678_ChIP-Seq_K562_Human2.38781449
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29797969
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26745165
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23303213
12MYB_26560356_Chip-Seq_TH2_Human2.22202050
13SCL_19346495_ChIP-Seq_HPC-7_Human2.20315549
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13043367
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.12105752
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09025634
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.04258719
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03878025
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.02399738
20IGF1R_20145208_ChIP-Seq_DFB_Human2.01171234
21ER_23166858_ChIP-Seq_MCF-7_Human1.98829745
22EZH2_22144423_ChIP-Seq_EOC_Human1.97059636
23EWS_26573619_Chip-Seq_HEK293_Human1.89247766
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.80755388
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79672656
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.72506519
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66009853
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59328172
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.57040686
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.56997519
31RUNX_20019798_ChIP-Seq_JUKART_Human1.56271827
32GATA3_26560356_Chip-Seq_TH2_Human1.51073118
33STAT3_23295773_ChIP-Seq_U87_Human1.49503700
34VDR_23849224_ChIP-Seq_CD4+_Human1.49326420
35GATA3_27048872_Chip-Seq_THYMUS_Human1.47237149
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46620944
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.44336300
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.42314568
39PRDM14_20953172_ChIP-Seq_ESCs_Human1.36364896
40VDR_24787735_ChIP-Seq_THP-1_Human1.36362067
41MYB_26560356_Chip-Seq_TH1_Human1.35337038
42ELK1_19687146_ChIP-ChIP_HELA_Human1.34415816
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34184949
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33790487
45SMAD4_21799915_ChIP-Seq_A2780_Human1.33466016
46ZNF274_21170338_ChIP-Seq_K562_Hela1.32839372
47CRX_20693478_ChIP-Seq_RETINA_Mouse1.32177344
48CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31863086
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30581944
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29991348
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29937061
52P300_19829295_ChIP-Seq_ESCs_Human1.29255695
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28754019
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28751344
55BCAT_22108803_ChIP-Seq_LS180_Human1.28256076
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.27734601
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27181116
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27059864
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23214528
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22768593
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22387239
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21990971
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20546956
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20371831
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16602422
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14732042
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13822919
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13336967
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.11003566
70GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.10798757
71OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10538461
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08735471
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08616542
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08479483
75CBP_20019798_ChIP-Seq_JUKART_Human1.06945299
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06945299
77KDM2B_26808549_Chip-Seq_REH_Human1.06312135
78RXR_22108803_ChIP-Seq_LS180_Human1.05958998
79RUNX2_22187159_ChIP-Seq_PCA_Human1.05132821
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04293063
81TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04062230
82GATA3_26560356_Chip-Seq_TH1_Human1.03657640
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03486485
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03367362
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03198682
86AR_25329375_ChIP-Seq_VCAP_Human1.02980415
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02579304
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.01799957
89CDX2_22108803_ChIP-Seq_LS180_Human1.01320756
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00287221
91BRD4_25478319_ChIP-Seq_HGPS_Human1.00096977
92NCOR_22424771_ChIP-Seq_293T_Human0.97197241
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96995166
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95704727
95FLI1_21867929_ChIP-Seq_TH2_Mouse0.95505806
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93523073
97TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92821585
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.92018613
99TCF4_23295773_ChIP-Seq_U87_Human0.91347575
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91269684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005174_abnormal_tail_pigmentation5.94502826
2MP0000569_abnormal_digit_pigmentation5.63426112
3MP0000015_abnormal_ear_pigmentation4.21018360
4MP0000372_irregular_coat_pigmentation3.34984440
5MP0005075_abnormal_melanosome_morpholog3.31176095
6MP0001188_hyperpigmentation3.27573097
7MP0004147_increased_porphyrin_level3.09966209
8MP0009379_abnormal_foot_pigmentation2.72536132
9MP0004885_abnormal_endolymph2.44370447
10MP0005671_abnormal_response_to2.43672341
11MP0008058_abnormal_DNA_repair2.15440022
12MP0003763_abnormal_thymus_physiology2.09104293
13MP0002095_abnormal_skin_pigmentation2.06630279
14MP0003868_abnormal_feces_composition2.01078159
15MP0004381_abnormal_hair_follicle1.96359476
16MP0000371_diluted_coat_color1.93500864
17MP0002277_abnormal_respiratory_mucosa1.88216528
18MP0001873_stomach_inflammation1.88012785
19MP0002166_altered_tumor_susceptibility1.86940913
20MP0001851_eye_inflammation1.83378589
21MP0002102_abnormal_ear_morphology1.68804187
22MP0004043_abnormal_pH_regulation1.67078583
23MP0004808_abnormal_hematopoietic_stem1.65654843
24MP0002009_preneoplasia1.59369602
25MP0002177_abnormal_outer_ear1.58352359
26MP0008877_abnormal_DNA_methylation1.58138249
27MP0003950_abnormal_plasma_membrane1.56564481
28MP0003724_increased_susceptibility_to1.50698394
29MP0002006_tumorigenesis1.44903237
30MP0005171_absent_coat_pigmentation1.42588739
31MP0005000_abnormal_immune_tolerance1.41326406
32MP0001501_abnormal_sleep_pattern1.37437358
33MP0006072_abnormal_retinal_apoptosis1.37105541
34MP0003136_yellow_coat_color1.36880961
35MP0004233_abnormal_muscle_weight1.34705923
36MP0001835_abnormal_antigen_presentation1.34531315
37MP0003718_maternal_effect1.34450441
38MP0002163_abnormal_gland_morphology1.28705476
39MP0002405_respiratory_system_inflammati1.27136968
40MP0002210_abnormal_sex_determination1.21699496
41MP0003656_abnormal_erythrocyte_physiolo1.21445792
42MP0002148_abnormal_hypersensitivity_rea1.20477072
43MP0001800_abnormal_humoral_immune1.19748436
44MP0009697_abnormal_copulation1.18436016
45MP0003866_abnormal_defecation1.12858144
46MP0009785_altered_susceptibility_to1.12236313
47MP0009333_abnormal_splenocyte_physiolog1.11092101
48MP0008995_early_reproductive_senescence1.10131870
49MP0002877_abnormal_melanocyte_morpholog1.09400400
50MP0000689_abnormal_spleen_morphology1.06611290
51MP0002837_dystrophic_cardiac_calcinosis1.05995763
52MP0002398_abnormal_bone_marrow1.05177572
53MP0002132_abnormal_respiratory_system1.04797557
54MP0000703_abnormal_thymus_morphology1.04428335
55MP0002723_abnormal_immune_serum1.03230489
56MP0002420_abnormal_adaptive_immunity1.00805700
57MP0000685_abnormal_immune_system0.99354246
58MP0003221_abnormal_cardiomyocyte_apopto0.98816325
59MP0005551_abnormal_eye_electrophysiolog0.98194178
60MP0005464_abnormal_platelet_physiology0.98028472
61MP0003786_premature_aging0.97554778
62MP0001764_abnormal_homeostasis0.97512784
63MP0002722_abnormal_immune_system0.97266497
64MP0001929_abnormal_gametogenesis0.95315724
65MP0003191_abnormal_cellular_cholesterol0.94000878
66MP0002736_abnormal_nociception_after0.93609350
67MP0001819_abnormal_immune_cell0.93262497
68MP0002452_abnormal_antigen_presenting0.92924129
69MP0002075_abnormal_coat/hair_pigmentati0.90164507
70MP0000465_gastrointestinal_hemorrhage0.88759337
71MP0005220_abnormal_exocrine_pancreas0.88714572
72MP0000653_abnormal_sex_gland0.85113934
73MP0003183_abnormal_peptide_metabolism0.82921841
74MP0002928_abnormal_bile_duct0.82236997
75MP0001299_abnormal_eye_distance/0.82112660
76MP0008961_abnormal_basal_metabolism0.80816117
77MP0000427_abnormal_hair_cycle0.77471089
78MP0001119_abnormal_female_reproductive0.76730404
79MP0005164_abnormal_response_to0.75645913
80MP0008057_abnormal_DNA_replication0.75364385
81MP0000716_abnormal_immune_system0.75124863
82MP0001324_abnormal_eye_pigmentation0.74208152
83MP0004142_abnormal_muscle_tone0.72541087
84MP0001664_abnormal_digestion0.72434274
85MP0002127_abnormal_cardiovascular_syste0.72004873
86MP0005025_abnormal_response_to0.71302744
87MP0001191_abnormal_skin_condition0.71091006
88MP0002419_abnormal_innate_immunity0.71020359
89MP0005395_other_phenotype0.68820823
90MP0005647_abnormal_sex_gland0.66863701
91MP0005310_abnormal_salivary_gland0.64514907
92MP0002938_white_spotting0.63820294
93MP0008469_abnormal_protein_level0.63734164
94MP0002933_joint_inflammation0.63361297
95MP0005397_hematopoietic_system_phenotyp0.63305351
96MP0001545_abnormal_hematopoietic_system0.63305351
97MP0001145_abnormal_male_reproductive0.62157755
98MP0001968_abnormal_touch/_nociception0.62123288
99MP0003436_decreased_susceptibility_to0.59807438
100MP0003699_abnormal_female_reproductive0.59442980

Predicted human phenotypes

RankGene SetZ-score
1Posterior subcapsular cataract (HP:0007787)5.54138245
2Albinism (HP:0001022)4.44852829
3Abnormality of midbrain morphology (HP:0002418)4.09618313
4Molar tooth sign on MRI (HP:0002419)4.09618313
5Aplastic anemia (HP:0001915)4.02493472
6Metaphyseal dysplasia (HP:0100255)3.79226871
7Medial flaring of the eyebrow (HP:0010747)3.36350939
8Pancreatic cysts (HP:0001737)3.24442625
9Nephrogenic diabetes insipidus (HP:0009806)3.18801141
10Abnormality of liposaccharide metabolism (HP:0010968)3.14541160
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.14541160
12Abnormality of glycolipid metabolism (HP:0010969)3.14541160
13Abnormality of the renal cortex (HP:0011035)3.03393988
14Ketoacidosis (HP:0001993)3.03235670
15Tachypnea (HP:0002789)2.98393614
16Spastic paraparesis (HP:0002313)2.94312073
17Choroideremia (HP:0001139)2.89091075
18Facial hemangioma (HP:0000329)2.87756057
19Congenital primary aphakia (HP:0007707)2.84380784
20Impaired proprioception (HP:0010831)2.84305881
21Severe combined immunodeficiency (HP:0004430)2.84043923
22Lip pit (HP:0100267)2.82809165
23Hypoproteinemia (HP:0003075)2.82784319
24Ocular albinism (HP:0001107)2.80851041
25Reduced subcutaneous adipose tissue (HP:0003758)2.66463432
26Gait imbalance (HP:0002141)2.66285523
27Autoimmune hemolytic anemia (HP:0001890)2.60439132
28Bilateral sensorineural hearing impairment (HP:0008619)2.56631488
29Abnormal auditory evoked potentials (HP:0006958)2.56270161
30Abnormality of DNA repair (HP:0003254)2.55763941
31Iris hypopigmentation (HP:0007730)2.55761591
32Premature ovarian failure (HP:0008209)2.50737827
33Pancreatic fibrosis (HP:0100732)2.50114131
34Poor coordination (HP:0002370)2.48190103
35White forelock (HP:0002211)2.47403647
36Ketosis (HP:0001946)2.46565883
37Optic neuritis (HP:0100653)2.45986161
38Retrobulbar optic neuritis (HP:0100654)2.45986161
39Hypoplasia of the iris (HP:0007676)2.44630225
40Subcapsular cataract (HP:0000523)2.42896904
41Patchy hypopigmentation of hair (HP:0011365)2.41849461
42Thyroiditis (HP:0100646)2.39834473
43Hypoplastic iliac wings (HP:0002866)2.36195015
44Combined immunodeficiency (HP:0005387)2.34693794
45Broad alveolar ridges (HP:0000187)2.34033317
46Methylmalonic acidemia (HP:0002912)2.27058785
47Anhidrosis (HP:0000970)2.26527504
48Hypothermia (HP:0002045)2.19730902
49Abnormality of the alveolar ridges (HP:0006477)2.19412703
50Abnormality of homocysteine metabolism (HP:0010919)2.18148860
51Homocystinuria (HP:0002156)2.18148860
52Neoplasm of the adrenal cortex (HP:0100641)2.16979823
53Horizontal nystagmus (HP:0000666)2.15643444
54Myositis (HP:0100614)2.12690177
55True hermaphroditism (HP:0010459)2.11817729
56Abnormality of eosinophils (HP:0001879)2.11428828
57Orchitis (HP:0100796)2.10642748
58Abnormality of the vitamin B12 metabolism (HP:0004341)2.10486956
59Genital tract atresia (HP:0001827)2.08357528
60Median cleft lip (HP:0000161)2.08250272
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07428963
62Nephronophthisis (HP:0000090)2.07378099
63Anterior segment dysgenesis (HP:0007700)2.06157291
64Renal cortical cysts (HP:0000803)2.05879305
65Heterochromia iridis (HP:0001100)2.04272618
66Secondary amenorrhea (HP:0000869)2.03124052
67B lymphocytopenia (HP:0010976)2.02547839
68Limb hypertonia (HP:0002509)1.99329174
69Tinnitus (HP:0000360)1.97325580
70Abnormality of the renal medulla (HP:0100957)1.96656386
71Gaze-evoked nystagmus (HP:0000640)1.96520555
72Abnormality of vitamin B metabolism (HP:0004340)1.94598458
73Esophageal neoplasm (HP:0100751)1.93574672
74Neoplasm of head and neck (HP:0012288)1.93574672
75Dyschromatopsia (HP:0007641)1.93143447
76Hypoplastic pelvis (HP:0008839)1.91997495
77Supernumerary spleens (HP:0009799)1.91175471
78Cystic liver disease (HP:0006706)1.91006268
79Tubulointerstitial fibrosis (HP:0005576)1.90843917
80Attenuation of retinal blood vessels (HP:0007843)1.90539872
81Constricted visual fields (HP:0001133)1.88809506
82Vaginal atresia (HP:0000148)1.88605295
83Tubular atrophy (HP:0000092)1.86607642
84Conjunctival telangiectasia (HP:0000524)1.86137083
85Intestinal atresia (HP:0011100)1.85681108
86Limb dystonia (HP:0002451)1.85197150
87Protruding tongue (HP:0010808)1.84410262
88Abnormality of B cell number (HP:0010975)1.84165915
89Oculomotor apraxia (HP:0000657)1.83200408
90Cutaneous melanoma (HP:0012056)1.81640387
91T lymphocytopenia (HP:0005403)1.81465194
92Aplasia/Hypoplasia of the lens (HP:0008063)1.79540842
93Recurrent bronchitis (HP:0002837)1.78891149
94Short chin (HP:0000331)1.77417590
95Tubulointerstitial abnormality (HP:0001969)1.77203774
96Anorexia (HP:0002039)1.74568993
97Meningioma (HP:0002858)1.72802193
98Fair hair (HP:0002286)1.71616231
99Abnormality of T cell number (HP:0011839)1.69495816
100Neoplasm of the peripheral nervous system (HP:0100007)1.69425366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.30152201
2TXK3.85498351
3FES3.75892237
4AKT33.45864075
5FRK2.85125377
6MAP3K62.70253732
7KIT2.03892426
8MARK32.03318163
9MATK1.89488796
10MKNK21.79783723
11TRPM71.79745814
12NUAK11.79189409
13DYRK31.74070620
14FER1.73746357
15MAP3K131.71225776
16MAP2K31.67816801
17PTK2B1.67408181
18PAK31.63989474
19SGK21.54858120
20MAPK71.54157557
21MUSK1.50648393
22MKNK11.50352944
23MAP3K101.47368250
24EIF2AK31.42984175
25MAP3K141.42730528
26EPHA31.38283478
27PIM11.34394747
28ITK1.30282945
29RIPK41.26060435
30CSK1.25200736
31MAP3K51.21839705
32GRK11.21675922
33MAPKAPK31.21077728
34TEC1.21010839
35GRK61.19589622
36KDR1.18159626
37RPS6KB21.18153914
38BRD41.18115018
39RPS6KA41.16678014
40CHUK1.13630841
41MAPK121.13209939
42PIK3CG1.09982582
43ADRBK21.07751234
44IRAK11.06288520
45OBSCN1.06069150
46ERBB31.01237317
47IKBKB1.00215848
48LCK0.97788782
49NEK60.96571802
50TAOK10.95148341
51TNIK0.90962226
52BMPR1B0.89773335
53RAF10.85140961
54NTRK30.80741128
55DMPK0.79509007
56MAP3K20.75147619
57CDK90.74915774
58YES10.74806809
59JAK10.73595192
60ADRBK10.70793180
61MAPKAPK20.69739072
62SGK30.69323401
63BRSK20.68027405
64PAK60.67741472
65PRKCI0.66937891
66CDC42BPA0.64937355
67PRKCQ0.64347662
68TNK20.62515906
69ZAK0.60251564
70HCK0.58385678
71VRK10.58054421
72MAP2K10.56561507
73ZAP700.52134643
74SGK2230.51013973
75SGK4940.51013973
76EPHB10.49492032
77TGFBR20.49375047
78IKBKE0.49193439
79IGF1R0.46943302
80MAP4K10.45832221
81LYN0.42295667
82RPS6KA50.42127918
83PAK20.40301046
84MAPK110.39792431
85SYK0.39712539
86HIPK20.38614657
87BRAF0.38290333
88MAPK130.38162256
89ABL10.38089898
90TLK10.37528721
91BMPR20.37183104
92INSR0.37161409
93MAPKAPK50.36801028
94KSR10.36629121
95NLK0.35480449
96ERN10.34092653
97PLK30.33805111
98MAPK90.33413481
99PRKACB0.31442629
100CDC70.30442361

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.49483894
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30929290
3Basal transcription factors_Homo sapiens_hsa030222.22821949
4T cell receptor signaling pathway_Homo sapiens_hsa046602.17502647
5Protein export_Homo sapiens_hsa030602.09429856
6Dorso-ventral axis formation_Homo sapiens_hsa043202.05326571
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.02380349
8Regulation of autophagy_Homo sapiens_hsa041401.97433610
9Primary immunodeficiency_Homo sapiens_hsa053401.85303996
10Hematopoietic cell lineage_Homo sapiens_hsa046401.81290344
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80432814
12Fanconi anemia pathway_Homo sapiens_hsa034601.67543154
13Circadian rhythm_Homo sapiens_hsa047101.64371404
14Other glycan degradation_Homo sapiens_hsa005111.60672458
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57584590
16RNA polymerase_Homo sapiens_hsa030201.56445724
17Measles_Homo sapiens_hsa051621.50317850
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50253019
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46725481
20RNA transport_Homo sapiens_hsa030131.44740389
21Linoleic acid metabolism_Homo sapiens_hsa005911.44458662
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43005678
23Caffeine metabolism_Homo sapiens_hsa002321.41027033
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39834696
25ABC transporters_Homo sapiens_hsa020101.39100829
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.37451826
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34736216
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.34233621
29Autoimmune thyroid disease_Homo sapiens_hsa053201.26054555
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25050771
31Graft-versus-host disease_Homo sapiens_hsa053321.24128072
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23462339
33Butanoate metabolism_Homo sapiens_hsa006501.21960454
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19361829
35B cell receptor signaling pathway_Homo sapiens_hsa046621.14786392
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.09408396
37MAPK signaling pathway_Homo sapiens_hsa040101.05630108
38Herpes simplex infection_Homo sapiens_hsa051681.05126412
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03888068
40Selenocompound metabolism_Homo sapiens_hsa004501.03847997
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97802061
42Nucleotide excision repair_Homo sapiens_hsa034200.97403771
43Nitrogen metabolism_Homo sapiens_hsa009100.96771164
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95175677
45TNF signaling pathway_Homo sapiens_hsa046680.94610685
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88099059
47p53 signaling pathway_Homo sapiens_hsa041150.87482123
48RNA degradation_Homo sapiens_hsa030180.86287419
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83894393
50Non-homologous end-joining_Homo sapiens_hsa034500.81243867
51African trypanosomiasis_Homo sapiens_hsa051430.80107330
52Osteoclast differentiation_Homo sapiens_hsa043800.79246048
53Melanoma_Homo sapiens_hsa052180.78008336
54Shigellosis_Homo sapiens_hsa051310.77621191
55Long-term depression_Homo sapiens_hsa047300.76970689
56Acute myeloid leukemia_Homo sapiens_hsa052210.76664815
57N-Glycan biosynthesis_Homo sapiens_hsa005100.75685574
58Viral myocarditis_Homo sapiens_hsa054160.75068332
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74359917
60Allograft rejection_Homo sapiens_hsa053300.74234165
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73061483
62Olfactory transduction_Homo sapiens_hsa047400.72954874
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.71285954
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70801099
65Propanoate metabolism_Homo sapiens_hsa006400.70062092
66FoxO signaling pathway_Homo sapiens_hsa040680.69190634
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68865634
68Malaria_Homo sapiens_hsa051440.68390009
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.68388292
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68098410
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.67093770
72Platelet activation_Homo sapiens_hsa046110.66246412
73Ether lipid metabolism_Homo sapiens_hsa005650.64875905
74Pancreatic cancer_Homo sapiens_hsa052120.64693668
75Proteasome_Homo sapiens_hsa030500.64445673
76Fatty acid biosynthesis_Homo sapiens_hsa000610.63036350
77Taste transduction_Homo sapiens_hsa047420.62731296
78Antigen processing and presentation_Homo sapiens_hsa046120.60666121
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60624007
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59968777
81Prolactin signaling pathway_Homo sapiens_hsa049170.56874656
82Hepatitis C_Homo sapiens_hsa051600.56491986
83Ras signaling pathway_Homo sapiens_hsa040140.55875802
84Long-term potentiation_Homo sapiens_hsa047200.55867615
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53484841
86Arachidonic acid metabolism_Homo sapiens_hsa005900.53020978
87Insulin resistance_Homo sapiens_hsa049310.52353523
88Ovarian steroidogenesis_Homo sapiens_hsa049130.51618522
89Rheumatoid arthritis_Homo sapiens_hsa053230.51301574
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.49324807
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49115613
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47903481
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47731061
94Phototransduction_Homo sapiens_hsa047440.47507351
95Hepatitis B_Homo sapiens_hsa051610.46798387
96Sphingolipid metabolism_Homo sapiens_hsa006000.46248064
97Prostate cancer_Homo sapiens_hsa052150.44671341
98VEGF signaling pathway_Homo sapiens_hsa043700.44638153
99mTOR signaling pathway_Homo sapiens_hsa041500.42646884
100Viral carcinogenesis_Homo sapiens_hsa052030.41658169

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