SEC14L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.53818240
2L-phenylalanine catabolic process (GO:0006559)7.53818240
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.20578084
4L-phenylalanine metabolic process (GO:0006558)7.20578084
5aromatic amino acid family catabolic process (GO:0009074)6.77613278
6exogenous drug catabolic process (GO:0042738)6.61465888
7hemidesmosome assembly (GO:0031581)6.50142925
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.43375602
9epoxygenase P450 pathway (GO:0019373)6.23080768
10tryptophan catabolic process (GO:0006569)6.10929088
11indole-containing compound catabolic process (GO:0042436)6.10929088
12indolalkylamine catabolic process (GO:0046218)6.10929088
13omega-hydroxylase P450 pathway (GO:0097267)6.09213053
14kynurenine metabolic process (GO:0070189)6.00358438
15bile acid biosynthetic process (GO:0006699)5.97557299
16alpha-linolenic acid metabolic process (GO:0036109)5.77497701
17tryptophan metabolic process (GO:0006568)5.74106763
18glyoxylate metabolic process (GO:0046487)5.68257025
19urea metabolic process (GO:0019627)5.65847679
20urea cycle (GO:0000050)5.65847679
21high-density lipoprotein particle remodeling (GO:0034375)5.63156159
22negative regulation of fibrinolysis (GO:0051918)5.50266195
23sulfur amino acid catabolic process (GO:0000098)5.35037114
24cysteine metabolic process (GO:0006534)5.31558087
25regulation of fibrinolysis (GO:0051917)5.30891261
26peptidyl-glutamic acid carboxylation (GO:0017187)5.28513144
27protein carboxylation (GO:0018214)5.28513144
28complement activation, alternative pathway (GO:0006957)5.23819561
29regulation of protein activation cascade (GO:2000257)5.21477736
30nitrogen cycle metabolic process (GO:0071941)5.19949856
31bile acid metabolic process (GO:0008206)5.10765637
32serine family amino acid catabolic process (GO:0009071)5.07284562
33regulation of cholesterol esterification (GO:0010872)4.98670539
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.93612115
35reverse cholesterol transport (GO:0043691)4.92191092
36aromatic amino acid family metabolic process (GO:0009072)4.91485823
37regulation of triglyceride catabolic process (GO:0010896)4.89233070
38regulation of complement activation (GO:0030449)4.87003334
39macromolecular complex remodeling (GO:0034367)4.82043040
40plasma lipoprotein particle remodeling (GO:0034369)4.82043040
41protein-lipid complex remodeling (GO:0034368)4.82043040
42tyrosine metabolic process (GO:0006570)4.77647401
43regulation of plasminogen activation (GO:0010755)4.72270511
44homocysteine metabolic process (GO:0050667)4.70838859
45phospholipid efflux (GO:0033700)4.68984745
46negative regulation of sterol transport (GO:0032372)4.63774046
47negative regulation of cholesterol transport (GO:0032375)4.63774046
48amino-acid betaine metabolic process (GO:0006577)4.62128053
49triglyceride homeostasis (GO:0070328)4.62024052
50acylglycerol homeostasis (GO:0055090)4.62024052
51alpha-amino acid catabolic process (GO:1901606)4.60999331
52lysine catabolic process (GO:0006554)4.54299204
53lysine metabolic process (GO:0006553)4.54299204
54drug metabolic process (GO:0017144)4.52734724
55cellular ketone body metabolic process (GO:0046950)4.43257612
56bile acid and bile salt transport (GO:0015721)4.41359102
57plasma lipoprotein particle clearance (GO:0034381)4.38843310
58coenzyme catabolic process (GO:0009109)4.36978724
59glycine metabolic process (GO:0006544)4.35244814
60cellular glucuronidation (GO:0052695)4.33791946
61indolalkylamine metabolic process (GO:0006586)4.31727034
62imidazole-containing compound metabolic process (GO:0052803)4.31660376
63cholesterol efflux (GO:0033344)4.31171161
64glutamate metabolic process (GO:0006536)4.28438829
65cellular amino acid catabolic process (GO:0009063)4.25141810
66cellular biogenic amine catabolic process (GO:0042402)4.23324375
67amine catabolic process (GO:0009310)4.23324375
68ethanol oxidation (GO:0006069)4.19253765
69serine family amino acid metabolic process (GO:0009069)4.13298017
70benzene-containing compound metabolic process (GO:0042537)4.12846671
71plasma lipoprotein particle assembly (GO:0034377)4.07746394
72dicarboxylic acid biosynthetic process (GO:0043650)4.07342821
73oxidative demethylation (GO:0070989)4.06570270
74low-density lipoprotein particle remodeling (GO:0034374)4.05417535
75cellular modified amino acid catabolic process (GO:0042219)4.05078207
76arginine metabolic process (GO:0006525)3.98430661
77serine family amino acid biosynthetic process (GO:0009070)3.95952293
78drug catabolic process (GO:0042737)3.95666752
79fibrinolysis (GO:0042730)3.93616961
80negative regulation of blood coagulation (GO:0030195)3.89582367
81negative regulation of hemostasis (GO:1900047)3.89582367
82aldehyde catabolic process (GO:0046185)3.89264690
83very-low-density lipoprotein particle assembly (GO:0034379)3.86176408
84positive regulation of triglyceride lipase activity (GO:0061365)3.86153479
85positive regulation of lipoprotein lipase activity (GO:0051006)3.86153479
86uronic acid metabolic process (GO:0006063)3.85652236
87glucuronate metabolic process (GO:0019585)3.85652236
88ketone body metabolic process (GO:1902224)3.83854795
89ethanol metabolic process (GO:0006067)3.81897906
90positive regulation of lipid catabolic process (GO:0050996)3.81766308
91negative regulation of lipase activity (GO:0060192)3.81185360
92desmosome organization (GO:0002934)3.80053518
93phospholipid homeostasis (GO:0055091)3.76730824
94cholesterol homeostasis (GO:0042632)3.76126017
95cofactor catabolic process (GO:0051187)3.74123847
96blood coagulation, intrinsic pathway (GO:0007597)3.73961719
97carboxylic acid catabolic process (GO:0046395)3.73085255
98organic acid catabolic process (GO:0016054)3.73085255
99regulation of bile acid biosynthetic process (GO:0070857)3.73082344
100phenylpropanoid metabolic process (GO:0009698)3.70503942
101regulation of cholesterol homeostasis (GO:2000188)3.70243299
102sterol homeostasis (GO:0055092)3.69834771
103complement activation, classical pathway (GO:0006958)3.69672464
104acetyl-CoA metabolic process (GO:0006084)3.69347283
105short-chain fatty acid metabolic process (GO:0046459)3.67916622
106protein-lipid complex assembly (GO:0065005)3.66603228
107plasma lipoprotein particle organization (GO:0071827)3.66539080
108complement activation (GO:0006956)3.65525137
109cytolysis (GO:0019835)3.63628312
110negative regulation of wound healing (GO:0061045)3.63524007
111protein activation cascade (GO:0072376)3.63281679
112negative regulation of coagulation (GO:0050819)3.57901340
113regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.56972901
114positive regulation of blood coagulation (GO:0030194)3.55143883
115positive regulation of hemostasis (GO:1900048)3.55143883
116response to nitrosative stress (GO:0051409)3.54192357
117flavonoid metabolic process (GO:0009812)3.51370700
118phosphate ion transmembrane transport (GO:0035435)3.38625034
119alkaloid metabolic process (GO:0009820)3.34771714
120positive regulation of coagulation (GO:0050820)3.27820701
121cell-substrate junction assembly (GO:0007044)3.24422511
122regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.23960499
123intestinal cholesterol absorption (GO:0030299)3.10149676
124negative regulation of lipid transport (GO:0032369)3.06688306
125negative regulation of protein activation cascade (GO:2000258)2.95388430
126fat-soluble vitamin biosynthetic process (GO:0042362)2.93133306
127acute-phase response (GO:0006953)2.91674686
128cell adhesion mediated by integrin (GO:0033627)2.89463458
129hormone catabolic process (GO:0042447)2.87265290
130response to mercury ion (GO:0046689)2.82982262
131S-adenosylmethionine metabolic process (GO:0046500)2.80890637
132opsonization (GO:0008228)2.79667975
133phosphate ion transport (GO:0006817)2.74739315
134positive regulation of wound healing (GO:0090303)2.72935862
135steroid catabolic process (GO:0006706)2.70740855
136glutamine family amino acid biosynthetic process (GO:0009084)2.70061507
137proline metabolic process (GO:0006560)2.68654652
138polyketide metabolic process (GO:0030638)2.68408441
139doxorubicin metabolic process (GO:0044598)2.68408441
140daunorubicin metabolic process (GO:0044597)2.68408441
141positive regulation of triglyceride metabolic process (GO:0090208)2.67618983
142lipoprotein metabolic process (GO:0042157)2.64265826
143drug transmembrane transport (GO:0006855)2.63901334
144heme transport (GO:0015886)2.59947733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.30454378
2TP63_17297297_ChIP-ChIP_HaCaT_Human7.88728450
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.11296976
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.90227754
5* LXR_22158963_ChIP-Seq_LIVER_Mouse6.46755244
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.26660514
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.92207315
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.73827294
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06996445
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.83861762
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.72345794
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.42449984
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06572004
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06088919
15* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7215404
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.93181452
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90638557
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80125501
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79632483
20RACK7_27058665_Chip-Seq_MCF-7_Human1.68057708
21UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66140889
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.65333679
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.65314785
24P63_26484246_Chip-Seq_KERATINOCYTES_Human1.63289491
25* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59333449
26* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59333449
27HTT_18923047_ChIP-ChIP_STHdh_Human1.55983436
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55902468
29CLOCK_20551151_ChIP-Seq_293T_Human1.53567905
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49671998
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47039786
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45878706
33* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40547994
34GATA1_22025678_ChIP-Seq_K562_Human1.35734537
35* UBF1/2_26484160_Chip-Seq_HMECs_Human1.34513886
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32390159
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31589869
38CTCF_27219007_Chip-Seq_Bcells_Human1.29998268
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27637438
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27537876
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27091163
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26327043
43KDM2B_26808549_Chip-Seq_K562_Human1.24831019
44* GATA2_21666600_ChIP-Seq_HMVEC_Human1.23758528
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22212997
46ATF3_27146783_Chip-Seq_COLON_Human1.21973094
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21678484
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19202931
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17590084
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17414708
51RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17179810
52SMC4_20622854_ChIP-Seq_HELA_Human1.16557710
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16474832
54* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16327880
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15841768
56TP53_22127205_ChIP-Seq_IMR90_Human1.12696390
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09607721
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07186470
59P68_20966046_ChIP-Seq_HELA_Human1.06324528
60JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04913294
61* TP63_22573176_ChIP-Seq_HFKS_Human1.04619824
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03875773
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03805750
64* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03676691
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03201978
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03128085
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03069905
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00992969
69* TET1_21451524_ChIP-Seq_MESCs_Mouse1.00871153
70CREB1_26743006_Chip-Seq_LNCaP_Human1.00307996
71SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99546851
72ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98862692
73TP53_23651856_ChIP-Seq_MEFs_Mouse0.98139766
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98027782
75TP53_18474530_ChIP-ChIP_U2OS_Human0.97699519
76ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96398367
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95425213
78* SA1_27219007_Chip-Seq_ERYTHROID_Human0.94548697
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93983990
80CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93055294
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89933638
82TET1_21490601_ChIP-Seq_MESCs_Mouse0.89088007
83CJUN_26792858_Chip-Seq_BT549_Human0.88376393
84NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88316541
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87814037
86TBX20_22080862_ChIP-Seq_HEART_Mouse0.87472398
87TBX20_22328084_ChIP-Seq_HEART_Mouse0.87472398
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87425529
89RARB_27405468_Chip-Seq_BRAIN_Mouse0.87373427
90ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87151548
91SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86468558
92* RUNX1_27514584_Chip-Seq_MCF-7_Human0.85089031
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84547341
94GATA4_25053715_ChIP-Seq_YYC3_Human0.83594247
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83524316
96ZNF263_19887448_ChIP-Seq_K562_Human0.82565390
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82471205
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82271600
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81322795
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75567401
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73187663
102RARA_24833708_ChIP-Seq_LIVER_Mouse0.72490739
103KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71637042
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70152434
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69284779
106NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69284779
107* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68912706
108IRF8_22096565_ChIP-ChIP_GC-B_Human0.67735139
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67086302
110* ESR2_21235772_ChIP-Seq_MCF-7_Human0.66912876
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66595633
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66214385
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63859971
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63147329
115RARB_24833708_ChIP-Seq_LIVER_Mouse0.61942634
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61033709
117LXR_22292898_ChIP-Seq_THP-1_Human0.59097235
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58156689
119CEBPB_22108803_ChIP-Seq_LS180_Human0.57178718
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.56685326
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.56254581
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55705056
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.55685126
124EGR1_19032775_ChIP-ChIP_M12_Human0.55651738
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.55146375
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54049535
127* MYC_19915707_ChIP-ChIP_AK7_Human0.52685148
128TAF15_26573619_Chip-Seq_HEK293_Human0.51703595
129CBP_21632823_ChIP-Seq_H3396_Human0.51062961
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.50929902
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50714408
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.49413386
133ESET_19884257_ChIP-Seq_ESCs_Mouse0.48723746
134AR_20517297_ChIP-Seq_VCAP_Human0.48699131
135STAT1_17558387_ChIP-Seq_HELA_Human0.48001428
136P53_21459846_ChIP-Seq_SAOS-2_Human0.47741110
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.47266985
138GATA1_19941826_ChIP-Seq_K562_Human0.46178531
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.45472814
140BCAT_22108803_ChIP-Seq_LS180_Human0.44801482
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44064596
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44047502
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.43997566
144PPAR_26484153_Chip-Seq_NCI-H1993_Human0.43462624
145TAF2_19829295_ChIP-Seq_ESCs_Human0.43404535
146* GATA1_19941827_ChIP-Seq_MEL_Mouse0.43253440
147GATA2_19941826_ChIP-Seq_K562_Human0.42902472
148* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42111144
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.41266239
150GATA6_25053715_ChIP-Seq_YYC3_Human0.41166452
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40406259
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39349080
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.39094732
154E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.37644424
155LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.37507977
156NCOR_22424771_ChIP-Seq_293T_Human0.36152186
157ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.35723750
158GATA3_24758297_ChIP-Seq_MCF-7_Human0.35201161
159SOX2_20726797_ChIP-Seq_SW620_Human0.35069011
160SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.35067880
161ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.35044064
162FOXH1_21741376_ChIP-Seq_EPCs_Human0.34957281
163GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.34620369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.38614475
2MP0005360_urolithiasis7.57532948
3MP0005085_abnormal_gallbladder_physiolo6.47105304
4MP0005365_abnormal_bile_salt6.21792250
5MP0008875_abnormal_xenobiotic_pharmacok5.23307200
6MP0003806_abnormal_nucleotide_metabolis4.26146626
7MP0003252_abnormal_bile_duct3.95582886
8* MP0010329_abnormal_lipoprotein_level3.52068872
9MP0009840_abnormal_foam_cell3.38454153
10MP0005083_abnormal_biliary_tract3.07892172
11MP0003195_calcinosis2.74308064
12MP0005332_abnormal_amino_acid2.72398116
13MP0001666_abnormal_nutrient_absorption2.68646326
14MP0003566_abnormal_cell_adhesion2.30737917
15MP0003191_abnormal_cellular_cholesterol2.28258015
16MP0005023_abnormal_wound_healing2.17319632
17MP0004019_abnormal_vitamin_homeostasis2.15449002
18MP0000609_abnormal_liver_physiology2.14707578
19* MP0002118_abnormal_lipid_homeostasis2.09606515
20MP0005409_darkened_coat_color2.07882338
21MP0009780_abnormal_chondrocyte_physiolo1.99066412
22MP0000762_abnormal_tongue_morphology1.96014979
23MP0000467_abnormal_esophagus_morphology1.92742193
24MP0003868_abnormal_feces_composition1.88550103
25MP0002138_abnormal_hepatobiliary_system1.88549692
26MP0004272_abnormal_basement_membrane1.88372404
27MP0005319_abnormal_enzyme/_coenzyme1.80614501
28MP0002060_abnormal_skin_morphology1.68129458
29MP0003453_abnormal_keratinocyte_physiol1.63711126
30MP0001764_abnormal_homeostasis1.62886541
31MP0005584_abnormal_enzyme/coenzyme_acti1.57075778
32MP0009697_abnormal_copulation1.55060951
33MP0001849_ear_inflammation1.47035319
34MP0005451_abnormal_body_composition1.45322368
35MP0003011_delayed_dark_adaptation1.44653632
36MP0000566_synostosis1.39606676
37MP0005423_abnormal_somatic_nervous1.35254846
38MP0008438_abnormal_cutaneous_collagen1.30358625
39MP0004859_abnormal_synaptic_plasticity1.25356430
40MP0003656_abnormal_erythrocyte_physiolo1.23656294
41MP0003941_abnormal_skin_development1.23272008
42MP0003091_abnormal_cell_migration1.22489374
43MP0003186_abnormal_redox_activity1.21933079
44MP0003879_abnormal_hair_cell1.20169275
45MP0009643_abnormal_urine_homeostasis1.18562975
46MP0002234_abnormal_pharynx_morphology1.17910481
47MP0005257_abnormal_intraocular_pressure1.16957982
48MP0003705_abnormal_hypodermis_morpholog1.16618088
49MP0005647_abnormal_sex_gland1.14009858
50MP0001502_abnormal_circadian_rhythm1.13831550
51MP0000598_abnormal_liver_morphology1.13308105
52MP0001216_abnormal_epidermal_layer1.12303248
53MP0000604_amyloidosis1.11869266
54MP0005275_abnormal_skin_tensile1.05171712
55MP0002254_reproductive_system_inflammat1.04458543
56MP0010771_integument_phenotype1.04089567
57MP0005501_abnormal_skin_physiology1.03635050
58MP0001958_emphysema1.02414898
59MP0009764_decreased_sensitivity_to1.02128936
60MP0000678_abnormal_parathyroid_gland0.98044448
61MP0009763_increased_sensitivity_to0.96606216
62MP0002098_abnormal_vibrissa_morphology0.95791226
63MP0002089_abnormal_postnatal_growth/wei0.92714963
64MP0002282_abnormal_trachea_morphology0.90871470
65MP0005636_abnormal_mineral_homeostasis0.89603522
66MP0008260_abnormal_autophagy0.89498713
67MP0010368_abnormal_lymphatic_system0.87881965
68MP0005623_abnormal_meninges_morphology0.84013235
69* MP0009642_abnormal_blood_homeostasis0.83964816
70MP0002249_abnormal_larynx_morphology0.82851981
71MP0008469_abnormal_protein_level0.82694565
72MP0005408_hypopigmentation0.82046737
73MP0003950_abnormal_plasma_membrane0.81950606
74MP0005376_homeostasis/metabolism_phenot0.79378084
75MP0006036_abnormal_mitochondrial_physio0.79038312
76MP0001915_intracranial_hemorrhage0.78317952
77MP0002078_abnormal_glucose_homeostasis0.77154712
78MP0005084_abnormal_gallbladder_morpholo0.76846753
79MP0009765_abnormal_xenobiotic_induced0.76716377
80MP0005171_absent_coat_pigmentation0.75800432
81MP0002876_abnormal_thyroid_physiology0.75549679
82MP0000377_abnormal_hair_follicle0.75466113
83MP0003329_amyloid_beta_deposits0.74920204
84MP0002896_abnormal_bone_mineralization0.73839939
85MP0000003_abnormal_adipose_tissue0.73838194
86MP0003690_abnormal_glial_cell0.72845271
87MP0002971_abnormal_brown_adipose0.71128649
88MP0005535_abnormal_body_temperature0.68831306
89MP0004130_abnormal_muscle_cell0.68826422
90MP0005334_abnormal_fat_pad0.68677600
91MP0005220_abnormal_exocrine_pancreas0.68410371
92MP0002822_catalepsy0.67283413
93MP0005670_abnormal_white_adipose0.67210774
94MP0000920_abnormal_myelination0.67181486
95MP0003183_abnormal_peptide_metabolism0.67045982
96MP0000013_abnormal_adipose_tissue0.66831220
97MP0005266_abnormal_metabolism0.66785678
98MP0004270_analgesia0.66576317
99MP0009931_abnormal_skin_appearance0.63654157
100MP0009053_abnormal_anal_canal0.63171479
101MP0003279_aneurysm0.61918522
102MP0000639_abnormal_adrenal_gland0.59553619
103MP0005448_abnormal_energy_balance0.58958809
104MP0001661_extended_life_span0.58528287
105MP0003634_abnormal_glial_cell0.57128368
106MP0000367_abnormal_coat/_hair0.56174624
107MP0001756_abnormal_urination0.56143769
108MP0006035_abnormal_mitochondrial_morpho0.55854164
109MP0002736_abnormal_nociception_after0.55498483
110MP0004858_abnormal_nervous_system0.55131055
111MP0002877_abnormal_melanocyte_morpholog0.54774034
112MP0000537_abnormal_urethra_morphology0.54269298
113MP0005595_abnormal_vascular_smooth0.53403707
114MP0001879_abnormal_lymphatic_vessel0.52813896
115MP0003632_abnormal_nervous_system0.52022416
116MP0005197_abnormal_uvea_morphology0.52004907
117MP0002063_abnormal_learning/memory/cond0.51866387
118MP0008874_decreased_physiological_sensi0.48667612
119MP0003075_altered_response_to0.47320395
120MP0005464_abnormal_platelet_physiology0.46871473
121MP0005395_other_phenotype0.46595059
122MP0003638_abnormal_response/metabolism_0.46438922
123MP0003718_maternal_effect0.45237684
124MP0002928_abnormal_bile_duct0.44882114
125MP0005248_abnormal_Harderian_gland0.44722952
126MP0008873_increased_physiological_sensi0.43292077
127MP0004782_abnormal_surfactant_physiolog0.42200231
128MP0008872_abnormal_physiological_respon0.42033804
129MP0002136_abnormal_kidney_physiology0.41420081
130MP0003953_abnormal_hormone_level0.41200684
131MP0005166_decreased_susceptibility_to0.40790488
132MP0004381_abnormal_hair_follicle0.40574384
133MP0002796_impaired_skin_barrier0.39942493
134MP0002837_dystrophic_cardiac_calcinosis0.37773499
135MP0000579_abnormal_nail_morphology0.37360079
136MP0005666_abnormal_adipose_tissue0.34613081
137MP0003436_decreased_susceptibility_to0.32743536
138MP0009672_abnormal_birth_weight0.32146884
139MP0009115_abnormal_fat_cell0.31667880
140MP0000230_abnormal_systemic_arterial0.31533372
141MP0001881_abnormal_mammary_gland0.30678651
142MP0003724_increased_susceptibility_to0.30441429
143MP0010234_abnormal_vibrissa_follicle0.29986898
144MP0004883_abnormal_blood_vessel0.29718445
145MP0002168_other_aberrant_phenotype0.29580691
146MP0000249_abnormal_blood_vessel0.29490339
147MP0009384_cardiac_valve_regurgitation0.29095982
148MP0002090_abnormal_vision0.28412660
149MP0002970_abnormal_white_adipose0.27878850
150MP0006082_CNS_inflammation0.27497493
151MP0001243_abnormal_dermal_layer0.26551774
152MP0005167_abnormal_blood-brain_barrier0.25021976
153MP0001853_heart_inflammation0.24710464
154MP0004264_abnormal_extraembryonic_tissu0.23431921
155MP0005164_abnormal_response_to0.23329494

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.38262920
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.37484216
3Intrahepatic cholestasis (HP:0001406)7.36018894
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.70111811
5Hypobetalipoproteinemia (HP:0003563)6.60003408
6Prolonged partial thromboplastin time (HP:0003645)6.50154024
7Xanthomatosis (HP:0000991)6.33506488
8Hyperlipoproteinemia (HP:0010980)5.61389847
9Complement deficiency (HP:0004431)5.29791380
10Hypolipoproteinemia (HP:0010981)4.86757756
11Joint hemorrhage (HP:0005261)4.71325546
12Epidermoid cyst (HP:0200040)4.59163515
13Hyperammonemia (HP:0001987)4.58923955
14Hyperglycinemia (HP:0002154)4.46478398
15Milia (HP:0001056)4.44494158
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.44018602
17Atrophic scars (HP:0001075)4.43923488
18Abnormality of the common coagulation pathway (HP:0010990)4.36398335
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.23973510
20Abnormality of methionine metabolism (HP:0010901)4.23570072
21Ketosis (HP:0001946)4.22042256
22Fat malabsorption (HP:0002630)4.19992352
23Hypoalphalipoproteinemia (HP:0003233)4.18015527
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.13118417
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09876948
26Hyperglycinuria (HP:0003108)3.94868217
27Abnormality of serine family amino acid metabolism (HP:0010894)3.94162152
28Abnormality of glycine metabolism (HP:0010895)3.94162152
29Onycholysis (HP:0001806)3.85176459
30Abnormality of complement system (HP:0005339)3.84268921
31Hypoglycemic coma (HP:0001325)3.82220174
32Conjugated hyperbilirubinemia (HP:0002908)3.80711570
33Abnormality of pyrimidine metabolism (HP:0004353)3.74698629
34Hypercholesterolemia (HP:0003124)3.69442661
35Abnormality of the intrinsic pathway (HP:0010989)3.69335411
36Fragile nails (HP:0001808)3.68697096
37Abnormality of nail color (HP:0100643)3.53298268
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36727980
39Hyperbilirubinemia (HP:0002904)3.35887989
40Abnormality of fatty-acid metabolism (HP:0004359)3.29908269
41Plantar hyperkeratosis (HP:0007556)3.23871889
42Delayed CNS myelination (HP:0002188)3.14363820
43Steatorrhea (HP:0002570)3.12454365
44Popliteal pterygium (HP:0009756)3.04875710
45Abnormality of serum amino acid levels (HP:0003112)3.03700034
46Abnormality of nucleobase metabolism (HP:0010932)3.02532821
47Hypochromic microcytic anemia (HP:0004840)3.02398682
48Neurofibrillary tangles (HP:0002185)3.00630195
49Ketoacidosis (HP:0001993)2.99981775
50Hepatocellular carcinoma (HP:0001402)2.96937426
51Spontaneous abortion (HP:0005268)2.93911141
52Myocardial infarction (HP:0001658)2.90797317
53Skin nodule (HP:0200036)2.79149416
54Metabolic acidosis (HP:0001942)2.78975952
55Acanthocytosis (HP:0001927)2.72415499
56Pterygium (HP:0001059)2.69877937
57Abnormality of purine metabolism (HP:0004352)2.66449916
58Systemic lupus erythematosus (HP:0002725)2.66082881
59Thick nail (HP:0001805)2.65336225
60Vascular calcification (HP:0004934)2.58221977
61Lethargy (HP:0001254)2.56111353
62Nail dystrophy (HP:0008404)2.55917991
63Ulnar bowing (HP:0003031)2.53299354
64Abnormal gallbladder morphology (HP:0012437)2.52630691
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51321796
66Dicarboxylic aciduria (HP:0003215)2.51321796
67Hypoglycemic seizures (HP:0002173)2.49111147
68Cerebral inclusion bodies (HP:0100314)2.47757509
69Spastic diplegia (HP:0001264)2.47697437
70Cholelithiasis (HP:0001081)2.46725921
71Atrioventricular block (HP:0001678)2.46552943
72Abnormal gallbladder physiology (HP:0012438)2.46094720
73Cholecystitis (HP:0001082)2.46094720
74Malnutrition (HP:0004395)2.40009948
75Gout (HP:0001997)2.39958777
76Mitral stenosis (HP:0001718)2.37671239
77Hypoplasia of dental enamel (HP:0006297)2.36304471
78Abnormality of the Achilles tendon (HP:0005109)2.36238809
79Neonatal onset (HP:0003623)2.35632929
80Alopecia of scalp (HP:0002293)2.35082933
81Glomerulonephritis (HP:0000099)2.34763112
82Irritability (HP:0000737)2.34724627
83Natal tooth (HP:0000695)2.32359290
84Cerebral edema (HP:0002181)2.32213525
85Amyloidosis (HP:0011034)2.31823881
86Protrusio acetabuli (HP:0003179)2.31250987
87Fragile skin (HP:0001030)2.29271211
88Recurrent gram-negative bacterial infections (HP:0005420)2.28337088
89Cardiovascular calcification (HP:0011915)2.28049538
90Arterial tortuosity (HP:0005116)2.25555952
91Sensorimotor neuropathy (HP:0007141)2.20864934
92Abnormal blistering of the skin (HP:0008066)2.20288643
93Esophageal varix (HP:0002040)2.18973429
94Brushfield spots (HP:0001088)2.18363111
95Poikilocytosis (HP:0004447)2.14118384
96Gingival bleeding (HP:0000225)2.11713942
97Late onset (HP:0003584)2.11369429
98Enlarged kidneys (HP:0000105)2.10764488
99Pancreatitis (HP:0001733)2.09918260
100Vascular tortuosity (HP:0004948)2.09438274
101Menorrhagia (HP:0000132)2.08530160
102Thin bony cortex (HP:0002753)2.06985260
103Palmoplantar hyperkeratosis (HP:0000972)2.04975479
104Short nail (HP:0001799)2.04960782
105Abnormality of the gallbladder (HP:0005264)2.03679500
106Vomiting (HP:0002013)2.03152560
107Coronal craniosynostosis (HP:0004440)2.02969581
108Opisthotonus (HP:0002179)2.01987518
109Hemorrhage of the eye (HP:0011885)2.01400393
110Hyperinsulinemic hypoglycemia (HP:0000825)2.00417271
111Ridged nail (HP:0001807)1.99691159
112Rickets (HP:0002748)1.98961843
113Thrombophlebitis (HP:0004418)1.98952985
114Turricephaly (HP:0000262)1.96480028
115Obstructive sleep apnea (HP:0002870)1.95769996
116Renal cortical cysts (HP:0000803)1.94017838
117Generalized aminoaciduria (HP:0002909)1.91721596
118Premature rupture of membranes (HP:0001788)1.91487476
119Abnormal hair laboratory examination (HP:0003328)1.89892818
120Status epilepticus (HP:0002133)1.87251647
121Hypophosphatemic rickets (HP:0004912)1.87224295
122Abnormal cartilage morphology (HP:0002763)1.86636078
123Abnormality of transition element cation homeostasis (HP:0011030)1.85912393
124Amniotic constriction ring (HP:0009775)1.85868149
125Abnormality of placental membranes (HP:0011409)1.85868149
126Cervical subluxation (HP:0003308)1.85847641
127Abnormality of iron homeostasis (HP:0011031)1.85513469
128Hydroxyprolinuria (HP:0003080)1.85087599
129Abnormality of proline metabolism (HP:0010907)1.85087599
130Palmar hyperkeratosis (HP:0010765)1.83738503
131Alkalosis (HP:0001948)1.79996378
132Advanced eruption of teeth (HP:0006288)1.79644632
133Abnormal atrioventricular conduction (HP:0005150)1.79539240
134Abnormality of vitamin metabolism (HP:0100508)1.79267773
135Abnormal enzyme/coenzyme activity (HP:0012379)1.79135673
136Shallow orbits (HP:0000586)1.78918611
137Elevated hepatic transaminases (HP:0002910)1.77563522
138Reticulocytosis (HP:0001923)1.75380444
139Split foot (HP:0001839)1.74914827
140Achilles tendon contracture (HP:0001771)1.74643104
141Right ventricular cardiomyopathy (HP:0011663)1.72735736
142Bronchomalacia (HP:0002780)1.71454595
143Bowed forearm bones (HP:0003956)1.70881556
144Bowing of the arm (HP:0006488)1.70881556
145Increased mean platelet volume (HP:0011877)1.69568745
146Broad face (HP:0000283)1.69420483
147Nephritis (HP:0000123)1.69210203
148Abnormality of carpal bone ossification (HP:0006257)1.66533818
149Dry hair (HP:0011359)1.66437278
150Tibial bowing (HP:0002982)1.63812611
151Back pain (HP:0003418)1.62944558
152Neonatal hypoglycemia (HP:0001998)1.61973342
153Pili torti (HP:0003777)1.59527141
154Distal upper limb amyotrophy (HP:0007149)1.59086252
155Upper limb amyotrophy (HP:0009129)1.59086252
156Akinesia (HP:0002304)1.56976656
157Heart block (HP:0012722)1.56383782
158Elevated alkaline phosphatase (HP:0003155)1.54837436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.96126746
2SIK14.72626975
3FGFR44.45129694
4ERN14.25460184
5NTRK13.18283058
6TAOK32.94104978
7INSRR2.85829156
8EPHA22.85619932
9ERBB42.80092616
10ARAF2.76840344
11PRPF4B2.69742510
12LMTK22.64166076
13MAP2K42.52267675
14EPHB22.27493851
15PKN22.22092796
16PDGFRA2.16800460
17MST1R2.15846528
18PIM22.01232317
19DAPK21.86165671
20MAPK111.82888282
21MAP3K91.82074698
22TRIB31.80968503
23PIK3CG1.80094401
24FLT31.71181835
25PRKD31.67486923
26LATS11.66071784
27FRK1.59315035
28PAK61.57143827
29TESK11.52956788
30TYK21.52174037
31STK381.51788317
32FGFR21.49490051
33PTK61.46577173
34ABL21.42368099
35PINK11.38026486
36MAP3K71.34966020
37MUSK1.26684280
38NEK91.21345707
39JAK21.19100406
40GRK61.19023338
41NTRK31.18704306
42KDR1.13521201
43PRKAA21.12135794
44ERBB21.08845265
45PHKG21.05185422
46PHKG11.05185422
47MAPK151.02657953
48MAP3K121.02398704
49PDGFRB1.02234204
50PRKD21.01003367
51MAP3K101.00497727
52MAP2K30.98241180
53NEK60.98035101
54PRKCZ0.97141395
55JAK10.97006665
56EPHA40.96670135
57MAPK40.92856258
58MOS0.89891625
59TBK10.89144479
60MET0.86694876
61EPHB10.85133508
62CDK60.85042533
63PAK40.85022427
64ROCK20.84629156
65DDR20.84173547
66MAPK120.82086434
67CAMK2G0.81213604
68STK38L0.80867875
69CAMK1D0.80427175
70RIPK10.78921799
71CAMK2B0.78319972
72MAP3K30.77660298
73PRKACG0.76944701
74MARK10.76411574
75MAP3K140.75638055
76PAK20.73927317
77SGK30.73675529
78LIMK10.73482604
79MAP3K110.72105782
80MAP2K60.71585430
81MAPKAPK30.71385238
82DYRK1B0.69007548
83MYLK0.68155375
84GSK3A0.67194721
85PRKAA10.66359089
86ROCK10.66086677
87TTN0.64280640
88CSK0.64086834
89PTK20.63644952
90TIE10.63420010
91TYRO30.62680586
92PDPK10.62532171
93RAF10.61123956
94MARK20.58861276
95CDK120.57039073
96MAPK70.56909405
97EPHA30.56831112
98CSNK1G10.55036721
99PRKCQ0.54624956
100SMG10.52848314
101MAP3K130.52831971
102BRAF0.52579402
103NTRK20.52338447
104MAP2K10.52108028
105PRKCG0.51235972
106SGK20.51235610
107FGFR30.50917203
108RPS6KA20.49956746
109RET0.49942223
110ICK0.49097327
111GRK10.47563136
112FER0.47215846
113PRKD10.46433721
114SGK4940.45571140
115SGK2230.45571140
116DAPK30.45096269
117CDK50.44319983
118ILK0.44225147
119CAMK1G0.43769513
120CSF1R0.43760449
121IKBKE0.43576147
122CSNK1G20.43259257
123AKT30.43230784
124TGFBR20.42496000
125PAK30.42479253
126TAOK20.41837212
127ZAP700.41772850
128CDC42BPA0.41743402
129NME20.41650720
130IGF1R0.40577601
131PKN10.40461717
132PDK10.40136765
133MAPK100.39557457
134IRAK30.39176297
135CAMK40.39164928
136CDK150.38871656
137MAP3K10.38567856
138SIK20.37706347
139SRC0.37403250
140WNK40.37366503
141GRK50.37004820
142CDK180.35390209
143LATS20.35346144
144MAP3K20.34811607
145MAP3K50.34415569
146CSNK1G30.34277954
147PBK0.33620760
148MAP3K60.32827751
149MTOR0.31044534
150EGFR0.30851947
151BMX0.30838347
152CDK40.30512119
153PRKCA0.29609355
154CAMKK10.29587367
155CSNK1A1L0.29046729
156KSR20.26847054
157IRAK20.25269402

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.50998537
2Nitrogen metabolism_Homo sapiens_hsa009103.65350288
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.42105255
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32468207
5Arginine biosynthesis_Homo sapiens_hsa002203.05728938
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.74059791
7Tryptophan metabolism_Homo sapiens_hsa003802.67483313
8Complement and coagulation cascades_Homo sapiens_hsa046102.67354717
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59813754
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50391775
11Fatty acid degradation_Homo sapiens_hsa000712.49900639
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35788321
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30274528
14Butanoate metabolism_Homo sapiens_hsa006502.18024925
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15633628
16Peroxisome_Homo sapiens_hsa041462.07347503
17Chemical carcinogenesis_Homo sapiens_hsa052041.95855053
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94566162
19Histidine metabolism_Homo sapiens_hsa003401.92732623
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.91735055
21Propanoate metabolism_Homo sapiens_hsa006401.90757521
22PPAR signaling pathway_Homo sapiens_hsa033201.88481270
23Fatty acid metabolism_Homo sapiens_hsa012121.82583629
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.77446890
25Caffeine metabolism_Homo sapiens_hsa002321.77379781
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73886736
27beta-Alanine metabolism_Homo sapiens_hsa004101.73105601
28Retinol metabolism_Homo sapiens_hsa008301.72492274
29Staphylococcus aureus infection_Homo sapiens_hsa051501.66653021
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64596839
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59033095
32Bile secretion_Homo sapiens_hsa049761.54119876
33Phenylalanine metabolism_Homo sapiens_hsa003601.52003799
34Selenocompound metabolism_Homo sapiens_hsa004501.51879514
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49049220
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42623600
37Tyrosine metabolism_Homo sapiens_hsa003501.41588673
38Pyruvate metabolism_Homo sapiens_hsa006201.37163135
39Sulfur metabolism_Homo sapiens_hsa009201.37118333
40Fatty acid elongation_Homo sapiens_hsa000621.34154658
41Starch and sucrose metabolism_Homo sapiens_hsa005001.31540917
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.29441053
43Fat digestion and absorption_Homo sapiens_hsa049751.23272688
44ABC transporters_Homo sapiens_hsa020101.21999160
45Folate biosynthesis_Homo sapiens_hsa007901.19782483
46Biosynthesis of amino acids_Homo sapiens_hsa012301.17687437
47Steroid biosynthesis_Homo sapiens_hsa001001.17300067
48Carbon metabolism_Homo sapiens_hsa012001.10654500
49ECM-receptor interaction_Homo sapiens_hsa045121.09941590
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07488907
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.01392079
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.98097313
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96823071
54Arginine and proline metabolism_Homo sapiens_hsa003300.95089947
55Vitamin B6 metabolism_Homo sapiens_hsa007500.94659558
56Sulfur relay system_Homo sapiens_hsa041220.94266063
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90000287
58Vitamin digestion and absorption_Homo sapiens_hsa049770.88953362
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82999750
60Lysine degradation_Homo sapiens_hsa003100.79610239
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76070864
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71388874
63Glycerolipid metabolism_Homo sapiens_hsa005610.70886938
64Glutathione metabolism_Homo sapiens_hsa004800.66866370
65One carbon pool by folate_Homo sapiens_hsa006700.66745705
66Fatty acid biosynthesis_Homo sapiens_hsa000610.62520858
67Pentose phosphate pathway_Homo sapiens_hsa000300.54126639
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50465518
69Focal adhesion_Homo sapiens_hsa045100.50044758
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47172956
71Mineral absorption_Homo sapiens_hsa049780.46070812
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45760534
73Metabolic pathways_Homo sapiens_hsa011000.44279579
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43899673
75Circadian rhythm_Homo sapiens_hsa047100.43540591
76Prion diseases_Homo sapiens_hsa050200.36187911
77Sphingolipid metabolism_Homo sapiens_hsa006000.34989253
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34005208
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32991698
80Galactose metabolism_Homo sapiens_hsa000520.29977785
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25604493
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24901002
83Fructose and mannose metabolism_Homo sapiens_hsa000510.24651478
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24294364
85Proteoglycans in cancer_Homo sapiens_hsa052050.23348541
86Insulin resistance_Homo sapiens_hsa049310.23026562
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22962629
88ErbB signaling pathway_Homo sapiens_hsa040120.22099424
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.21991334
90Glutamatergic synapse_Homo sapiens_hsa047240.21412743
91Linoleic acid metabolism_Homo sapiens_hsa005910.19570312
92Synaptic vesicle cycle_Homo sapiens_hsa047210.19064974
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18155057
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.17728429
95Pertussis_Homo sapiens_hsa051330.16394799
96Small cell lung cancer_Homo sapiens_hsa052220.16020921
97Glioma_Homo sapiens_hsa052140.15967836
98Cocaine addiction_Homo sapiens_hsa050300.13666815
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13355417
100GABAergic synapse_Homo sapiens_hsa047270.12492865
101Long-term potentiation_Homo sapiens_hsa047200.11505593
102Glucagon signaling pathway_Homo sapiens_hsa049220.10642463
103VEGF signaling pathway_Homo sapiens_hsa043700.10245202
104Axon guidance_Homo sapiens_hsa043600.09447511
105Adherens junction_Homo sapiens_hsa045200.09101622
106Serotonergic synapse_Homo sapiens_hsa047260.08552348
107AMPK signaling pathway_Homo sapiens_hsa041520.01710335
108Amoebiasis_Homo sapiens_hsa05146-0.2395281
109Type II diabetes mellitus_Homo sapiens_hsa04930-0.2358056
110Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2248241
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2230144
112Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2196318
113Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1946350
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1895517
115Hepatitis C_Homo sapiens_hsa05160-0.1889732
116Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1688628
117Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1647810
118Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1631625
119Regulation of autophagy_Homo sapiens_hsa04140-0.1592261
120Renin-angiotensin system_Homo sapiens_hsa04614-0.1557064
121Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1513389
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1477157
123African trypanosomiasis_Homo sapiens_hsa05143-0.1400221
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1094234
125Insulin signaling pathway_Homo sapiens_hsa04910-0.0909971
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0857742
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0644033
128Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0613037

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