SEC14L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1xenobiotic catabolic process (GO:0042178)9.57592370
2surfactant homeostasis (GO:0043129)9.57203798
3axoneme assembly (GO:0035082)8.85053020
4regulation of cilium movement (GO:0003352)8.09038251
5chemical homeostasis within a tissue (GO:0048875)7.84236998
6one-carbon compound transport (GO:0019755)7.00763644
7response to nitrosative stress (GO:0051409)6.89168425
8phenylpropanoid metabolic process (GO:0009698)6.45817812
9left/right pattern formation (GO:0060972)6.22982752
10left/right axis specification (GO:0070986)6.22125034
11uronic acid metabolic process (GO:0006063)6.08404693
12glucuronate metabolic process (GO:0019585)6.08404693
13intraciliary transport (GO:0042073)5.96495817
14cilium organization (GO:0044782)5.70887301
15regulation of skeletal muscle contraction (GO:0014819)5.67496775
16cellular glucuronidation (GO:0052695)5.66324798
17cilium assembly (GO:0042384)5.53620157
18positive regulation of endothelial cell differentiation (GO:0045603)5.41503949
19L-ascorbic acid metabolic process (GO:0019852)5.34595829
20microtubule bundle formation (GO:0001578)5.25646856
21protein localization to cilium (GO:0061512)5.19009218
22regulation of microtubule-based movement (GO:0060632)5.05016703
23ventricular system development (GO:0021591)4.99078933
24negative regulation of fatty acid transport (GO:2000192)4.95515406
25hormone catabolic process (GO:0042447)4.77198049
26response to xenobiotic stimulus (GO:0009410)4.71233770
27cilium morphogenesis (GO:0060271)4.70036314
28relaxation of cardiac muscle (GO:0055119)4.60287357
29regulation of chemokine secretion (GO:0090196)4.55414799
30regulation of endothelial cell differentiation (GO:0045601)4.51529552
31cellular component assembly involved in morphogenesis (GO:0010927)4.39043139
32glutathione derivative metabolic process (GO:1901685)4.36365311
33glutathione derivative biosynthetic process (GO:1901687)4.36365311
34centriole assembly (GO:0098534)4.30387226
35regulation of vasculogenesis (GO:2001212)4.29448245
36establishment of apical/basal cell polarity (GO:0035089)4.19474892
37vitamin transmembrane transport (GO:0035461)4.16215811
38positive regulation of chemokine secretion (GO:0090197)4.13220515
39negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.07215982
40regulation of cholesterol biosynthetic process (GO:0045540)4.02109126
41calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.96936548
42ethanol oxidation (GO:0006069)3.94259443
43positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.87625698
44primary alcohol catabolic process (GO:0034310)3.83388786
45regulation of secondary heart field cardioblast proliferation (GO:0003266)3.82818075
46regulation of cardioblast proliferation (GO:0003264)3.82818075
47microtubule-based movement (GO:0007018)3.81961018
48establishment of monopolar cell polarity (GO:0061162)3.81944287
49establishment or maintenance of monopolar cell polarity (GO:0061339)3.81944287
50negative regulation of T cell differentiation in thymus (GO:0033085)3.75946318
51nonmotile primary cilium assembly (GO:0035058)3.70523215
52photoreceptor cell maintenance (GO:0045494)3.70199111
53peptide catabolic process (GO:0043171)3.68943490
54cell projection assembly (GO:0030031)3.67304031
55lateral ventricle development (GO:0021670)3.64317437
56benzene-containing compound metabolic process (GO:0042537)3.61894682
57renal absorption (GO:0070293)3.61465088
58positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.58648951
59Notch signaling involved in heart development (GO:0061314)3.57201520
60negative regulation of immunoglobulin mediated immune response (GO:0002890)3.52521675
61negative regulation of B cell mediated immunity (GO:0002713)3.52521675
62dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.51520041
63cellular response to nitric oxide (GO:0071732)3.51222018
64regulation of interleukin-13 production (GO:0032656)3.51162754
65retinal cone cell development (GO:0046549)3.50220647
66negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.49733694
67interleukin-6-mediated signaling pathway (GO:0070102)3.47625750
68toxin metabolic process (GO:0009404)3.44412532
69lung vasculature development (GO:0060426)3.43731365
70ethanol metabolic process (GO:0006067)3.35956810
71inner ear receptor cell differentiation (GO:0060113)3.35885085
72endothelial tube morphogenesis (GO:0061154)3.35628902
73morphogenesis of an endothelium (GO:0003159)3.35628902
74centriole replication (GO:0007099)3.35257954
75blood vessel maturation (GO:0001955)3.32758233
76diterpenoid biosynthetic process (GO:0016102)3.32501793
77positive regulation of steroid biosynthetic process (GO:0010893)3.32409965
78sperm motility (GO:0030317)3.31353942
79pyrimidine-containing compound transmembrane transport (GO:0072531)3.30648185
80negative regulation of lipase activity (GO:0060192)3.26879042
81tight junction assembly (GO:0070830)3.26466699
82drug catabolic process (GO:0042737)3.25432659
83protein polyglutamylation (GO:0018095)3.19020608
84retinal rod cell development (GO:0046548)3.15878311
85gas transport (GO:0015669)3.15442780
86energy homeostasis (GO:0097009)3.15312595
87aorta morphogenesis (GO:0035909)3.14496847
88lymphangiogenesis (GO:0001946)3.13511706
89tolerance induction (GO:0002507)3.12366304
90cornea development in camera-type eye (GO:0061303)3.11737514
91sodium-independent organic anion transport (GO:0043252)3.11608055
92myoblast migration (GO:0051451)3.10829906
93glutathione metabolic process (GO:0006749)3.10612765
94lung lobe morphogenesis (GO:0060463)3.09635956
95cilium movement (GO:0003341)3.09613606
96exogenous drug catabolic process (GO:0042738)3.09103268
97sensory perception of smell (GO:0007608)3.08986334
98relaxation of muscle (GO:0090075)3.08964954
99establishment of epithelial cell polarity (GO:0090162)3.06440690
100negative regulation of humoral immune response (GO:0002921)3.05481284
101nucleotide transmembrane transport (GO:1901679)3.04761797
102smoothened signaling pathway (GO:0007224)3.04266523
103positive regulation of hormone biosynthetic process (GO:0046886)3.02802501
104regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.96785649
105regulation of germinal center formation (GO:0002634)2.96280918
106flavonoid metabolic process (GO:0009812)2.96046492
107determination of left/right symmetry (GO:0007368)2.94112698
108cellular response to reactive nitrogen species (GO:1902170)2.92011818
109regulation of glomerular filtration (GO:0003093)2.90624544
110regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.90531181
111polarized epithelial cell differentiation (GO:0030859)2.89363383
112nucleoside diphosphate phosphorylation (GO:0006165)2.88916747
113endothelial cell differentiation (GO:0045446)2.88366751
114cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.87871983
115phosphatidylethanolamine metabolic process (GO:0046337)2.86059820
116multicellular organismal water homeostasis (GO:0050891)2.85729148
117behavioral response to nicotine (GO:0035095)2.85567712
118cytoplasmic microtubule organization (GO:0031122)2.80193613
119lung alveolus development (GO:0048286)2.80039309
120phosphatidylethanolamine biosynthetic process (GO:0006646)2.79955759
121positive regulation of p38MAPK cascade (GO:1900745)2.78184862
122bundle of His cell to Purkinje myocyte communication (GO:0086069)2.77531083
123determination of bilateral symmetry (GO:0009855)2.77070043
124endocardial cushion morphogenesis (GO:0003203)2.75640196
125microtubule polymerization or depolymerization (GO:0031109)2.75046770
126detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74458861
127establishment of endothelial barrier (GO:0061028)2.74358070
128sodium ion homeostasis (GO:0055078)2.73683265
129lung epithelium development (GO:0060428)2.70321513
130metanephric mesenchyme development (GO:0072075)2.70233607
131retinoic acid metabolic process (GO:0042573)2.69915171
132respiratory tube development (GO:0030323)2.69863403
133cellular ketone body metabolic process (GO:0046950)2.69510714
134regulation of interleukin-5 production (GO:0032674)2.69462549
135generation of neurons (GO:0048699)2.69414616
136positive regulation of type 2 immune response (GO:0002830)2.69091090
137response to interleukin-6 (GO:0070741)2.68583538
138specification of symmetry (GO:0009799)2.68353240
139ketone body metabolic process (GO:1902224)2.68003995
140microtubule depolymerization (GO:0007019)2.67719811
141bone remodeling (GO:0046849)2.66772543
142muscle cell migration (GO:0014812)2.65892883
143camera-type eye morphogenesis (GO:0048593)2.65819834
144regulation of steroid hormone biosynthetic process (GO:0090030)2.65237922
145branching involved in salivary gland morphogenesis (GO:0060445)2.64289036
146thyroid hormone metabolic process (GO:0042403)2.62593095
147negative regulation of axon extension involved in axon guidance (GO:0048843)2.61199357
148cell differentiation involved in metanephros development (GO:0072202)2.60372147
149facial nerve structural organization (GO:0021612)2.59292350
150glomerulus development (GO:0032835)2.57729307
151artery development (GO:0060840)2.57558392
152organelle assembly (GO:0070925)2.56182864
153cellular potassium ion homeostasis (GO:0030007)2.55849269
154organic cation transport (GO:0015695)2.54792668
155aldehyde catabolic process (GO:0046185)2.53668666
156detection of light stimulus involved in visual perception (GO:0050908)2.53211667
157detection of light stimulus involved in sensory perception (GO:0050962)2.53211667
158thyroid hormone generation (GO:0006590)2.53022683
159regulation of collateral sprouting (GO:0048670)2.50302210
160appendage development (GO:0048736)2.47664866
161limb development (GO:0060173)2.47664866
162terpenoid biosynthetic process (GO:0016114)2.47043422
163sialylation (GO:0097503)2.43966376
164respiratory chain complex IV assembly (GO:0008535)2.43406515
165spermatid development (GO:0007286)2.43130128
166piRNA metabolic process (GO:0034587)2.43096382
167neurotransmitter metabolic process (GO:0042133)2.42875986
168response to pheromone (GO:0019236)2.41405012
169neural tube formation (GO:0001841)2.41366369
170photoreceptor cell development (GO:0042461)2.40950947
171microtubule-based process (GO:0007017)2.37894104
172multicellular organism reproduction (GO:0032504)2.36875061
173phosphatidylcholine biosynthetic process (GO:0006656)2.36867566
174glomerular epithelial cell development (GO:0072310)2.36449555
175positive regulation of tolerance induction (GO:0002645)2.34604036
176fucose catabolic process (GO:0019317)2.34058125
177L-fucose metabolic process (GO:0042354)2.34058125
178L-fucose catabolic process (GO:0042355)2.34058125
179spinal cord motor neuron differentiation (GO:0021522)2.31810885
180oligosaccharide biosynthetic process (GO:0009312)2.31474503
181rRNA catabolic process (GO:0016075)2.29848169
182sperm capacitation (GO:0048240)2.29541682
183axonemal dynein complex assembly (GO:0070286)15.2592852
184cilium or flagellum-dependent cell motility (GO:0001539)14.5446938
185epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.8419250
186epithelial cilium movement (GO:0003351)10.4725306
187motile cilium assembly (GO:0044458)10.2815868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.10877534
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.82297611
3VDR_22108803_ChIP-Seq_LS180_Human3.80946123
4ZNF274_21170338_ChIP-Seq_K562_Hela3.27705652
5ESR1_20079471_ChIP-ChIP_T-47D_Human2.91254347
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.89154082
7GATA1_22025678_ChIP-Seq_K562_Human2.76438763
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61382922
9CLOCK_20551151_ChIP-Seq_293T_Human2.57078203
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.56434843
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.45857812
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.38351698
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37504839
14IGF1R_20145208_ChIP-Seq_DFB_Human2.32062917
15ZNF217_24962896_ChIP-Seq_MCF-7_Human2.31152111
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.24957253
17AHR_22903824_ChIP-Seq_MCF-7_Human2.24369787
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16831257
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13946917
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09971214
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.09679753
22GBX2_23144817_ChIP-Seq_PC3_Human2.07409420
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06726193
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06198672
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89874993
26TAF15_26573619_Chip-Seq_HEK293_Human1.89351544
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.88813090
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86752915
29SOX2_20726797_ChIP-Seq_SW620_Human1.84615268
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.82433545
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.82433545
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80138450
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.77695525
34FUS_26573619_Chip-Seq_HEK293_Human1.77185659
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75124229
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74124451
37ER_23166858_ChIP-Seq_MCF-7_Human1.73798611
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.73763684
39TP53_18474530_ChIP-ChIP_U2OS_Human1.73137290
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.72604548
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71208391
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68515165
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68511015
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.68279391
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67595199
46SMAD4_21799915_ChIP-Seq_A2780_Human1.67522515
47P300_19829295_ChIP-Seq_ESCs_Human1.66345775
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.63212951
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62828386
50STAT3_23295773_ChIP-Seq_U87_Human1.60741996
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.59541539
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58159725
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.54557351
54* EWS_26573619_Chip-Seq_HEK293_Human1.52848464
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52182001
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50383879
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50383879
58TCF4_23295773_ChIP-Seq_U87_Human1.49972417
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.48225656
60CBP_20019798_ChIP-Seq_JUKART_Human1.46241957
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46241957
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.45358905
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.44728406
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44728406
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42787616
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42477239
67* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41825492
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41111699
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39592249
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38807399
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37034867
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36989845
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36124900
74TCF4_22108803_ChIP-Seq_LS180_Human1.35834941
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.35148929
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34706512
77AR_25329375_ChIP-Seq_VCAP_Human1.34006188
78CJUN_26792858_Chip-Seq_BT549_Human1.33485453
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.33269546
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33136589
81GATA4_25053715_ChIP-Seq_YYC3_Human1.32408603
82NCOR_22424771_ChIP-Seq_293T_Human1.32263614
83ETV1_20927104_ChIP-Seq_GIST48_Human1.32225888
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31767204
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.31388765
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29846748
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.29011154
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27083379
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.26064640
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25575845
91* REST_21632747_ChIP-Seq_MESCs_Mouse1.23227823
92SOX2_19829295_ChIP-Seq_ESCs_Human1.23112505
93NANOG_19829295_ChIP-Seq_ESCs_Human1.23112505
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.22964851
95PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.22846840
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22712972
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22712972
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22639548
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22616213
100AR_20517297_ChIP-Seq_VCAP_Human1.22194683
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21049551
102TP53_22573176_ChIP-Seq_HFKS_Human1.20494976
103KLF5_25053715_ChIP-Seq_YYC3_Human1.19092684
104AR_21572438_ChIP-Seq_LNCaP_Human1.18900423
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18864530
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18091515
107PHF8_20622853_ChIP-Seq_HELA_Human1.17851601
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17001073
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16013019
110RBPJ_21746931_ChIP-Seq_IB4_Human1.15938930
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.15926962
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15635010
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15617923
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15611960
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15593863
116GATA3_21878914_ChIP-Seq_MCF-7_Human1.15380053
117IRF1_19129219_ChIP-ChIP_H3396_Human1.15080597
118SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15028830
119CDX2_22108803_ChIP-Seq_LS180_Human1.14846926
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14727865
121EZH2_22144423_ChIP-Seq_EOC_Human1.14307001
122MYC_19829295_ChIP-Seq_ESCs_Human1.14106957
123FOXO3_23340844_ChIP-Seq_DLD1_Human1.14054371
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.13874210
125* SMRT_27268052_Chip-Seq_Bcells_Human1.13683071
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13216025
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12163043
128BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11258836
129SALL1_21062744_ChIP-ChIP_HESCs_Human1.11237344
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09478835
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09324043
132HOXB7_26014856_ChIP-Seq_BT474_Human1.08771122
133GATA3_24758297_ChIP-Seq_MCF-7_Human1.08588277
134CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08557846
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08368661
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08309289
137TP63_23658742_ChIP-Seq_EP156T_Human1.06480538
138CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06403494
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06278612
140RXR_22158963_ChIP-Seq_LIVER_Mouse1.05743354
141ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05555902
142EZH2_27294783_Chip-Seq_NPCs_Mouse1.05204881
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05010955
144ZNF263_19887448_ChIP-Seq_K562_Human1.04318867
145STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04140440
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04031242
147CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03509062
148RACK7_27058665_Chip-Seq_MCF-7_Human1.03400072
149IRF8_22096565_ChIP-ChIP_GC-B_Human1.03289033
150HNFA_21074721_ChIP-Seq_CACO-2_Human1.03090651
151NFYB_21822215_ChIP-Seq_K562_Human1.02538274
152BCAT_22108803_ChIP-Seq_LS180_Human1.02506099
153TBX20_22080862_ChIP-Seq_HEART_Mouse1.02458497
154TBX20_22328084_ChIP-Seq_HEART_Mouse1.02458497
155STAT3_18555785_Chip-Seq_ESCs_Mouse1.01595419
156TBL1_22424771_ChIP-Seq_293T_Human1.01494072
157NANOG_18555785_Chip-Seq_ESCs_Mouse1.01435323
158P53_22387025_ChIP-Seq_ESCs_Mouse1.01153529
159NFYA_21822215_ChIP-Seq_K562_Human0.99941047
160CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99867432
161* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99339328
162GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99172869
163TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98791079
164TP53_16413492_ChIP-PET_HCT116_Human0.98619281
165NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98368092
166RUNX_20019798_ChIP-Seq_JUKART_Human0.98242922
167EGR1_19374776_ChIP-ChIP_THP-1_Human0.96731240
168CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95110202
169FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94475987
170EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91581452
171CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89186985
172PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88817668
173FOXA1_25552417_ChIP-Seq_VCAP_Human0.88756654
174TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88615322
175TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88472943
176SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86708700
177EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85801134
178RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85801134
179JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84139469
180* DROSHA_22980978_ChIP-Seq_HELA_Human0.83375679
181P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82660469
182SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82115322
183JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81882507
184PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81413659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.75656002
2MP0008789_abnormal_olfactory_epithelium5.39358393
3MP0005499_abnormal_olfactory_system5.29204485
4MP0005394_taste/olfaction_phenotype5.29204485
5MP0004782_abnormal_surfactant_physiolog5.16927659
6MP0002653_abnormal_ependyma_morphology4.47403121
7MP0001984_abnormal_olfaction4.26518095
8MP0001958_emphysema3.78087604
9MP0002132_abnormal_respiratory_system3.64245227
10MP0010368_abnormal_lymphatic_system2.78844528
11MP0004133_heterotaxia2.68634961
12MP0010030_abnormal_orbit_morphology2.62346556
13MP0008995_early_reproductive_senescence2.57106354
14MP0002876_abnormal_thyroid_physiology2.39409106
15MP0002102_abnormal_ear_morphology2.27619849
16MP0002277_abnormal_respiratory_mucosa2.26868457
17MP0005551_abnormal_eye_electrophysiolog2.18994703
18MP0002138_abnormal_hepatobiliary_system2.11308310
19MP0003136_yellow_coat_color2.09436128
20MP0005388_respiratory_system_phenotype2.04206459
21MP0002133_abnormal_respiratory_system2.04206459
22MP0001879_abnormal_lymphatic_vessel2.01919047
23MP0002638_abnormal_pupillary_reflex1.96360169
24MP0009046_muscle_twitch1.93120280
25MP0003186_abnormal_redox_activity1.90962845
26MP0009053_abnormal_anal_canal1.89922019
27MP0001968_abnormal_touch/_nociception1.89199858
28MP0002233_abnormal_nose_morphology1.88964039
29MP0003195_calcinosis1.87844180
30MP0002160_abnormal_reproductive_system1.86996298
31MP0001177_atelectasis1.79581287
32MP0002295_abnormal_pulmonary_circulatio1.77764813
33MP0005408_hypopigmentation1.76288085
34MP0005253_abnormal_eye_physiology1.75978400
35MP0008877_abnormal_DNA_methylation1.72820112
36MP0000534_abnormal_ureter_morphology1.70399591
37MP0003566_abnormal_cell_adhesion1.63259712
38MP0009780_abnormal_chondrocyte_physiolo1.62190358
39MP0004272_abnormal_basement_membrane1.61097620
40MP0003011_delayed_dark_adaptation1.59274123
41MP0003191_abnormal_cellular_cholesterol1.58249294
42MP0004147_increased_porphyrin_level1.58232784
43MP0009745_abnormal_behavioral_response1.58132159
44MP0008872_abnormal_physiological_respon1.57912935
45MP0003724_increased_susceptibility_to1.57053625
46MP0000383_abnormal_hair_follicle1.56998374
47MP0001986_abnormal_taste_sensitivity1.56570104
48MP0002735_abnormal_chemical_nociception1.56199654
49MP0005083_abnormal_biliary_tract1.55250031
50MP0002736_abnormal_nociception_after1.51042074
51MP0005646_abnormal_pituitary_gland1.50976626
52MP0003787_abnormal_imprinting1.46244124
53MP0005167_abnormal_blood-brain_barrier1.45954456
54MP0002877_abnormal_melanocyte_morpholog1.45654460
55MP0001485_abnormal_pinna_reflex1.45517945
56MP0002909_abnormal_adrenal_gland1.43937833
57MP0002272_abnormal_nervous_system1.42470349
58MP0004885_abnormal_endolymph1.41228999
59MP0005075_abnormal_melanosome_morpholog1.38704563
60MP0005377_hearing/vestibular/ear_phenot1.35628264
61MP0003878_abnormal_ear_physiology1.35628264
62MP0006276_abnormal_autonomic_nervous1.35274226
63MP0003656_abnormal_erythrocyte_physiolo1.34768022
64MP0000427_abnormal_hair_cycle1.32375473
65MP0002282_abnormal_trachea_morphology1.31689938
66MP0004142_abnormal_muscle_tone1.31596022
67MP0005389_reproductive_system_phenotype1.30721578
68MP0000678_abnormal_parathyroid_gland1.30708605
69MP0009379_abnormal_foot_pigmentation1.30431768
70MP0005164_abnormal_response_to1.30168147
71MP0005248_abnormal_Harderian_gland1.29800040
72MP0001970_abnormal_pain_threshold1.29671604
73MP0000465_gastrointestinal_hemorrhage1.29298480
74MP0002139_abnormal_hepatobiliary_system1.28983800
75MP0002837_dystrophic_cardiac_calcinosis1.25137396
76MP0001529_abnormal_vocalization1.22118883
77MP0004883_abnormal_blood_vessel1.21511029
78MP0001501_abnormal_sleep_pattern1.18366026
79MP0000631_abnormal_neuroendocrine_gland1.17894850
80MP0001346_abnormal_lacrimal_gland1.17158436
81MP0001765_abnormal_ion_homeostasis1.16615535
82MP0001486_abnormal_startle_reflex1.16210893
83MP0000762_abnormal_tongue_morphology1.16016609
84MP0004019_abnormal_vitamin_homeostasis1.12756293
85MP0005636_abnormal_mineral_homeostasis1.12368399
86MP0003279_aneurysm1.11940578
87MP0002098_abnormal_vibrissa_morphology1.11404242
88MP0002928_abnormal_bile_duct1.11041715
89MP0000372_irregular_coat_pigmentation1.10939986
90MP0003698_abnormal_male_reproductive1.09115587
91MP0002572_abnormal_emotion/affect_behav1.08322221
92MP0005174_abnormal_tail_pigmentation1.06977780
93MP0001929_abnormal_gametogenesis1.06149560
94MP0003646_muscle_fatigue1.05859124
95MP0002734_abnormal_mechanical_nocicepti1.04297926
96MP0001324_abnormal_eye_pigmentation1.02752154
97MP0000767_abnormal_smooth_muscle1.02370296
98MP0003252_abnormal_bile_duct1.01467325
99MP0003890_abnormal_embryonic-extraembry1.01173804
100MP0000015_abnormal_ear_pigmentation1.01042351
101MP0002332_abnormal_exercise_endurance0.99868046
102MP0006072_abnormal_retinal_apoptosis0.99846220
103MP0008004_abnormal_stomach_pH0.99263692
104MP0005645_abnormal_hypothalamus_physiol0.97807525
105MP0003075_altered_response_to0.97492509
106MP0010678_abnormal_skin_adnexa0.96760628
107MP0001188_hyperpigmentation0.96698559
108MP0001851_eye_inflammation0.95238604
109MP0003880_abnormal_central_pattern0.94660299
110MP0002822_catalepsy0.93360867
111MP0003718_maternal_effect0.92873478
112MP0003690_abnormal_glial_cell0.91951223
113MP0001502_abnormal_circadian_rhythm0.91449579
114MP0005395_other_phenotype0.91427014
115MP0002229_neurodegeneration0.90731443
116MP0005595_abnormal_vascular_smooth0.90196171
117MP0001175_abnormal_lung_morphology0.90012108
118MP0002733_abnormal_thermal_nociception0.89525226
119MP0005166_decreased_susceptibility_to0.88032568
120MP0002557_abnormal_social/conspecific_i0.87647691
121MP0000613_abnormal_salivary_gland0.87005287
122MP0002405_respiratory_system_inflammati0.86528412
123MP0002067_abnormal_sensory_capabilities0.86126184
124MP0003942_abnormal_urinary_system0.85904444
125MP0002064_seizures0.85866559
126MP0000026_abnormal_inner_ear0.85418693
127MP0004924_abnormal_behavior0.84489347
128MP0005386_behavior/neurological_phenoty0.84489347
129MP0001963_abnormal_hearing_physiology0.83500777
130MP0006036_abnormal_mitochondrial_physio0.80656431
131MP0005365_abnormal_bile_salt0.79976785
132MP0001542_abnormal_bone_strength0.79468259
133MP0005195_abnormal_posterior_eye0.78302514
134MP0000569_abnormal_digit_pigmentation0.76843385
135MP0010234_abnormal_vibrissa_follicle0.76522864
136MP0001764_abnormal_homeostasis0.76176927
137MP0000537_abnormal_urethra_morphology0.74754626
138MP0001905_abnormal_dopamine_level0.73695360
139MP0005085_abnormal_gallbladder_physiolo0.72560585
140MP0010329_abnormal_lipoprotein_level0.71768120
141MP0009764_decreased_sensitivity_to0.71311353
142MP0002063_abnormal_learning/memory/cond0.70644704
143MP0000249_abnormal_blood_vessel0.70117575
144MP0004145_abnormal_muscle_electrophysio0.70096933
145MP0002095_abnormal_skin_pigmentation0.69781333
146MP0003115_abnormal_respiratory_system0.69528959
147MP0008775_abnormal_heart_ventricle0.68430665
148MP0001756_abnormal_urination0.67900975
149MP0001293_anophthalmia0.67493163
150MP0003303_peritoneal_inflammation0.67464326
151MP0000343_altered_response_to0.67362388
152MP0005423_abnormal_somatic_nervous0.67166131
153MP0001849_ear_inflammation0.66343534
154MP0010352_gastrointestinal_tract_polyps0.66185071
155MP0009250_abnormal_appendicular_skeleto0.65188872
156MP0005647_abnormal_sex_gland0.64703555
157MP0002168_other_aberrant_phenotype0.62496281
158MP0003300_gastrointestinal_ulcer0.62451004
159MP0003937_abnormal_limbs/digits/tail_de0.61740973
160MP0000467_abnormal_esophagus_morphology0.61522943
161MP0005397_hematopoietic_system_phenotyp0.59132215
162MP0001545_abnormal_hematopoietic_system0.59132215
163MP0002796_impaired_skin_barrier0.58719869
164MP0002136_abnormal_kidney_physiology0.58655783
165MP0004043_abnormal_pH_regulation0.58624368
166MP0003786_premature_aging0.58607232
167MP0005197_abnormal_uvea_morphology0.56680133
168MP0009643_abnormal_urine_homeostasis0.56419998
169MP0001919_abnormal_reproductive_system0.56380541
170MP0005165_increased_susceptibility_to0.55626893
171MP0005266_abnormal_metabolism0.55178772
172MP0000566_synostosis0.54318540
173MP0002234_abnormal_pharynx_morphology0.54092238
174MP0003091_abnormal_cell_migration0.54075321
175MP0005023_abnormal_wound_healing0.53743280
176MP0005275_abnormal_skin_tensile0.53610272
177MP0003828_pulmonary_edema0.53332560
178MP0003453_abnormal_keratinocyte_physiol0.52163666
179MP0000049_abnormal_middle_ear0.50151091
180MP0002135_abnormal_kidney_morphology0.49974537
181MP0005376_homeostasis/metabolism_phenot0.48521336
182MP0010155_abnormal_intestine_physiology0.47967318
183MP0009384_cardiac_valve_regurgitation0.44563051
184MP0002925_abnormal_cardiovascular_devel0.43877218

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)6.52048492
2Interstitial pulmonary disease (HP:0006530)6.20682367
3Hyperactive renin-angiotensin system (HP:0000841)6.14547064
4Facial shape deformation (HP:0011334)6.04416549
5Potter facies (HP:0002009)6.04416549
6Pancreatic fibrosis (HP:0100732)4.70945721
7Polycythemia (HP:0001901)4.57308260
8True hermaphroditism (HP:0010459)4.53859867
9Pancreatic cysts (HP:0001737)4.48118241
10Molar tooth sign on MRI (HP:0002419)4.14904917
11Abnormality of midbrain morphology (HP:0002418)4.14904917
12Renal salt wasting (HP:0000127)4.12098253
13Tubulointerstitial fibrosis (HP:0005576)3.90626958
14Nephronophthisis (HP:0000090)3.88037706
15Hyperkalemia (HP:0002153)3.86793964
16Stomach cancer (HP:0012126)3.80306796
17Abnormality of the nasal mucosa (HP:0000433)3.77494653
18Occipital encephalocele (HP:0002085)3.73982239
19Tubulointerstitial nephritis (HP:0001970)3.73378330
20Onycholysis (HP:0001806)3.72011537
21Ulnar bowing (HP:0003031)3.71905966
22Recurrent sinusitis (HP:0011108)3.63588762
23Abnormal hemoglobin (HP:0011902)3.62834200
24Hematochezia (HP:0002573)3.62249230
25Cystic liver disease (HP:0006706)3.60851146
26Synostosis involving the elbow (HP:0003938)3.57700107
27Humeroradial synostosis (HP:0003041)3.57700107
28Abnormal ciliary motility (HP:0012262)3.54277038
29Abnormal respiratory motile cilium physiology (HP:0012261)3.53438832
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.43717022
31Infertility (HP:0000789)3.33416137
32Chronic hepatic failure (HP:0100626)3.29309847
33Hyperaldosteronism (HP:0000859)3.28361094
34Abnormality of the renal medulla (HP:0100957)3.18833070
35Bifid scrotum (HP:0000048)3.14343476
36Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.13003021
37Bronchiectasis (HP:0002110)3.12814970
38Medial flaring of the eyebrow (HP:0010747)3.11205125
39Bronchitis (HP:0012387)3.05847021
40Lip pit (HP:0100267)3.04664595
41Decreased circulating renin level (HP:0003351)3.03759946
42Pulmonary artery stenosis (HP:0004415)2.96314657
43Tubulointerstitial abnormality (HP:0001969)2.95207374
44Esophageal varix (HP:0002040)2.92207556
45Tachypnea (HP:0002789)2.91832701
46Postaxial foot polydactyly (HP:0001830)2.91255291
47Bronchomalacia (HP:0002780)2.89857877
48Periauricular skin pits (HP:0100277)2.89382267
49Preauricular pit (HP:0004467)2.89382267
50Rhinitis (HP:0012384)2.84322141
51Abnormality of the phalanges of the 2nd finger (HP:0009541)2.78687582
52Recurrent otitis media (HP:0000403)2.76053742
53Gait imbalance (HP:0002141)2.73907666
54Congenital hepatic fibrosis (HP:0002612)2.71674709
55Congenital primary aphakia (HP:0007707)2.70740699
56Abnormality of renin-angiotensin system (HP:0000847)2.70174510
57Aplasia involving bones of the upper limbs (HP:0009823)2.67356860
58Aplasia of the phalanges of the hand (HP:0009802)2.67356860
59Aplasia involving bones of the extremities (HP:0009825)2.67356860
60Bowing of the arm (HP:0006488)2.66805422
61Bowed forearm bones (HP:0003956)2.66805422
62Abnormal respiratory epithelium morphology (HP:0012253)2.66798959
63Abnormal respiratory motile cilium morphology (HP:0005938)2.66798959
64Hypoplastic scapulae (HP:0000882)2.66585961
65Aplasia/Hypoplasia of the scapulae (HP:0006713)2.66585961
66Anencephaly (HP:0002323)2.65341914
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.65207273
68Renal tubular acidosis (HP:0001947)2.64011103
69Sclerocornea (HP:0000647)2.55839289
70Stenosis of the external auditory canal (HP:0000402)2.55757513
71Spontaneous hematomas (HP:0007420)2.55441700
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.52832750
73Right ventricular cardiomyopathy (HP:0011663)2.51593184
74Male infertility (HP:0003251)2.51250097
75Redundant skin (HP:0001582)2.49436645
76Male pseudohermaphroditism (HP:0000037)2.46278198
77Labial hypoplasia (HP:0000066)2.44598837
78Abnormality of the middle phalanges of the toes (HP:0010183)2.42971652
79Nephrogenic diabetes insipidus (HP:0009806)2.42368656
80Chronic otitis media (HP:0000389)2.41264031
81Osteolytic defects of the phalanges of the hand (HP:0009771)2.36718137
82Osteolytic defects of the hand bones (HP:0009699)2.36718137
83Decreased central vision (HP:0007663)2.34339645
84Tarsal synostosis (HP:0008368)2.32041175
85Persistence of primary teeth (HP:0006335)2.31497156
86Respiratory distress (HP:0002098)2.30926536
87Gout (HP:0001997)2.29045220
88Abnormal rod and cone electroretinograms (HP:0008323)2.27198288
89Conjunctival telangiectasia (HP:0000524)2.27045850
90Asplenia (HP:0001746)2.26418075
91Aplasia/Hypoplasia of the spleen (HP:0010451)2.26131631
92Furrowed tongue (HP:0000221)2.22715763
93Hypoplastic female external genitalia (HP:0012815)2.22382721
94Oculomotor apraxia (HP:0000657)2.21817959
95Visceral angiomatosis (HP:0100761)2.21168070
96Abnormal biliary tract physiology (HP:0012439)2.20730335
97Bile duct proliferation (HP:0001408)2.20730335
98Hypotension (HP:0002615)2.19017164
99Intestinal atresia (HP:0011100)2.18920760
100Adactyly (HP:0009776)2.18083540
101Abnormality of chloride homeostasis (HP:0011422)2.17986966
102Congenital stationary night blindness (HP:0007642)2.17188123
103Synostosis involving bones of the feet (HP:0009140)2.16871465
104Synostosis involving bones of the lower limbs (HP:0009138)2.16871465
105Short hallux (HP:0010109)2.15511507
106Vaginal fistula (HP:0004320)2.14139822
107Syncope (HP:0001279)2.13293337
108Annular pancreas (HP:0001734)2.08492864
109Absent speech (HP:0001344)2.07424969
110Postaxial hand polydactyly (HP:0001162)2.07212974
111Tubular atrophy (HP:0000092)2.05481787
112Polydipsia (HP:0001959)2.05208576
113Abnormal drinking behavior (HP:0030082)2.05208576
114Down-sloping shoulders (HP:0200021)2.03136516
115Abnormality of the 2nd finger (HP:0004100)2.02437167
116Femoral bowing (HP:0002980)2.02414197
117Abnormality of the renal cortex (HP:0011035)2.02175148
118Poor coordination (HP:0002370)2.01021626
119Hypokalemic alkalosis (HP:0001949)1.98155999
120Fibular aplasia (HP:0002990)1.97474557
121Genital tract atresia (HP:0001827)1.97203865
122Vaginal atresia (HP:0000148)1.94458868
123Aplasia/Hypoplasia of the hallux (HP:0008362)1.92491276
124Growth hormone excess (HP:0000845)1.92278096
125Hyperventilation (HP:0002883)1.92040557
126Abolished electroretinogram (ERG) (HP:0000550)1.92035549
127Abnormality of the vasculature of the conjunctiva (HP:0008054)1.91849452
128Hemangiomatosis (HP:0007461)1.91453517
129Skin pits (HP:0100276)1.90886138
130Absent/shortened dynein arms (HP:0200106)1.89354296
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.89354296
132Long clavicles (HP:0000890)1.89272688
133Hypoplasia of the ulna (HP:0003022)1.88928036
134Nasal polyposis (HP:0100582)1.87339981
135Palpitations (HP:0001962)1.86567022
136Abnormality of cochlea (HP:0000375)1.84775316
137Cerebral palsy (HP:0100021)1.83221984
138Abnormality of the distal phalanges of the toes (HP:0010182)1.82837114
139Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.81487930
140Eczematoid dermatitis (HP:0000976)1.80846990
141Split foot (HP:0001839)1.77300104
142Chronic sinusitis (HP:0011109)1.74688514
143Preaxial hand polydactyly (HP:0001177)1.74139347
144Hyponatremia (HP:0002902)1.74037480
145Abnormality of sodium homeostasis (HP:0010931)1.73073040
146Cupped ear (HP:0000378)1.72204760
147Atelectasis (HP:0100750)1.70998947
148Nephropathy (HP:0000112)1.65180179
149Abnormality of macular pigmentation (HP:0008002)1.60532019
150Retinitis pigmentosa (HP:0000510)1.60120689
151Recurrent bronchitis (HP:0002837)1.59666545
152Gaze-evoked nystagmus (HP:0000640)1.56944452
153Type II lissencephaly (HP:0007260)1.54827535
154Polyuria (HP:0000103)1.54701871
155Narrow forehead (HP:0000341)1.52351711
156Supernumerary spleens (HP:0009799)1.45062323
157Aganglionic megacolon (HP:0002251)1.42705197
158Prominent nasal bridge (HP:0000426)1.41775212
159Disproportionate short-trunk short stature (HP:0003521)1.40173331
160Broad-based gait (HP:0002136)1.36746934
161Aplasia/Hypoplasia of the lens (HP:0008063)1.36239314
162Bell-shaped thorax (HP:0001591)1.35947302
163Bony spicule pigmentary retinopathy (HP:0007737)1.35936738
164Central scotoma (HP:0000603)1.34856608
165Median cleft lip (HP:0000161)1.34732669
166Multicystic kidney dysplasia (HP:0000003)1.33149172
167Attenuation of retinal blood vessels (HP:0007843)1.32951935
168Highly arched eyebrow (HP:0002553)1.29990386
169Stage 5 chronic kidney disease (HP:0003774)1.29559515
170Specific learning disability (HP:0001328)1.26650774
171Pendular nystagmus (HP:0012043)1.24880633
172Abnormality of renal excretion (HP:0011036)1.24180551
173Dyschromatopsia (HP:0007641)1.23989103
174Abnormal urine output (HP:0012590)1.22124553
175Hip dysplasia (HP:0001385)1.21591596
176Protruding tongue (HP:0010808)1.19480857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.72266623
2MAP3K34.42956227
3MST44.22466555
4MAP3K23.14501172
5MAP4K23.12179863
6TGFBR23.07621859
7FER2.44471181
8ERBB32.33302437
9STK102.25473268
10PINK12.24665725
11EPHB22.24597711
12DAPK22.22465782
13EPHB12.21722770
14MAP3K42.20150276
15MAPK152.19845848
16ADRBK22.13082976
17EPHA22.09793712
18ACVR1B2.08454003
19WNK32.06548217
20WNK42.04983775
21TESK12.02002214
22ZAK2.01714976
23EPHA31.95855039
24RIPK11.94743301
25MAP2K31.83044111
26LRRK21.82431039
27BMPR1B1.76766754
28OXSR11.74391186
29STK391.63185205
30CASK1.61566530
31RPS6KB21.58858236
32TLK11.54921063
33GRK11.53629032
34TRIB31.50206333
35PAK41.46945778
36FRK1.46087118
37BMPR21.41901817
38STK38L1.40610054
39MAPK131.39512837
40FGFR41.39133881
41MYLK1.38079435
42MAP3K121.34548908
43TAOK11.27389486
44TAOK21.25231431
45TRPM71.24873190
46TEC1.24180896
47TXK1.22400339
48PAK31.21474919
49CSNK1A1L1.20864237
50STK161.19946095
51HIPK21.17268015
52PTK2B1.16120350
53FGFR21.13574006
54MAP2K71.12131142
55ILK1.08170191
56NUAK11.07965298
57TRIM281.07593781
58FGFR31.04208300
59LIMK11.02789513
60PDGFRB0.99256946
61MAPKAPK30.98309266
62MAP2K10.97822490
63MAP3K110.94174492
64CDK190.92637334
65ADRBK10.91925118
66ZAP700.91588219
67PRKCQ0.85732534
68NTRK30.84968594
69LATS10.84844773
70NLK0.82514950
71PNCK0.81295863
72MST1R0.79932338
73CSK0.78550033
74TNIK0.76687530
75PRKD10.76208595
76BRSK20.75996600
77PRKCG0.75532770
78MAP2K20.74127922
79MAP2K60.73177851
80PRKCI0.72069411
81CDK60.67473287
82PLK20.67422892
83MKNK20.66448846
84STK40.66053500
85DYRK20.65985895
86PRKCE0.65597581
87ERN10.64639740
88CAMKK20.64213489
89SGK20.63324355
90CSNK1G30.62857644
91GSK3A0.61793183
92MAP2K40.61292382
93SGK30.61019146
94PTK20.60069118
95TTK0.59805640
96IKBKE0.59666022
97BCKDK0.59253719
98PHKG10.58887126
99PHKG20.58887126
100CSNK1G10.57966024
101MATK0.57057404
102CSNK1G20.56716065
103PDPK10.55044463
104SGK4940.54634058
105SGK2230.54634058
106EPHA40.52504122
107ERBB20.52333745
108LMTK20.49571567
109PRKAA20.49556964
110PRKCH0.49076866
111JAK10.48116190
112MARK10.48061103
113IRAK10.47996887
114PRKACA0.47958619
115MAP3K10.47320763
116STK30.46713608
117EGFR0.46627509
118TNK20.46123456
119TAOK30.45675872
120PLK10.45445649
121ITK0.44917273
122CAMK2A0.42994908
123STK240.42593493
124GRK70.42184840
125PDGFRA0.41726263
126ROCK10.41566621
127NEK90.41324470
128ROCK20.41135806
129PRKCZ0.40043525
130BCR0.39844952
131PTK60.38559648
132MAP3K70.38253171
133NME10.37938320
134EIF2AK10.37908937
135STK110.37473593
136PRKCA0.36656045
137MINK10.36141730
138KDR0.35680358
139CAMK2B0.35062871
140WEE10.34441181
141SIK20.34286850
142NEK60.33185610
143PKN10.33021761
144MARK20.32799004
145MUSK0.32295497
146EIF2AK30.32177205
147RPS6KA50.30744577
148PIK3CA0.30403006
149SGK10.29772077
150DYRK1A0.29503788
151CSNK1A10.29201845
152PRKG20.29066933
153CHUK0.28547268
154CAMK2D0.27828594
155MET0.27538019
156CSNK1D0.27507721
157MAP3K140.26813058
158ABL10.26656578
159SRC0.26519690
160GRK60.26392680
161CLK10.26268904
162MAPKAPK20.26032387
163INSRR0.26023340
164IGF1R0.24902973
165GRK50.24512229
166PRKCD0.24386723
167CAMK10.23125084
168PRKG10.22453445

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009825.21146230
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.08398689
3Pentose and glucuronate interconversions_Homo sapiens_hsa000404.96123805
4Chemical carcinogenesis_Homo sapiens_hsa052044.16622631
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.14739172
6Sulfur metabolism_Homo sapiens_hsa009203.46752605
7Linoleic acid metabolism_Homo sapiens_hsa005912.92897828
8Glutathione metabolism_Homo sapiens_hsa004802.84774396
9Caffeine metabolism_Homo sapiens_hsa002322.47572082
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.44533709
11Phototransduction_Homo sapiens_hsa047442.41765802
12Retinol metabolism_Homo sapiens_hsa008302.41459579
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34062699
14Huntingtons disease_Homo sapiens_hsa050162.22811902
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.19370064
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.98395882
17Nicotine addiction_Homo sapiens_hsa050331.96708979
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88134378
19Sulfur relay system_Homo sapiens_hsa041221.74350826
20Nitrogen metabolism_Homo sapiens_hsa009101.68318355
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65499939
22Ether lipid metabolism_Homo sapiens_hsa005651.57288738
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57017330
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.55120762
25Mineral absorption_Homo sapiens_hsa049781.54719245
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.54404296
27Adherens junction_Homo sapiens_hsa045201.50514744
28Starch and sucrose metabolism_Homo sapiens_hsa005001.49945566
29Histidine metabolism_Homo sapiens_hsa003401.46871157
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46829802
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42274195
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.40348390
33Tight junction_Homo sapiens_hsa045301.38923927
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37314442
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30988928
36Sphingolipid metabolism_Homo sapiens_hsa006001.24930826
37Propanoate metabolism_Homo sapiens_hsa006401.20525971
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.19907922
39ECM-receptor interaction_Homo sapiens_hsa045121.13026138
40beta-Alanine metabolism_Homo sapiens_hsa004101.11848441
41Collecting duct acid secretion_Homo sapiens_hsa049661.03902047
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03831754
43Regulation of autophagy_Homo sapiens_hsa041401.03769375
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01334345
45Rheumatoid arthritis_Homo sapiens_hsa053231.01310684
46Oxidative phosphorylation_Homo sapiens_hsa001900.95497393
47Fanconi anemia pathway_Homo sapiens_hsa034600.94427615
48Basal transcription factors_Homo sapiens_hsa030220.90506999
49Selenocompound metabolism_Homo sapiens_hsa004500.88538632
50Protein export_Homo sapiens_hsa030600.86907495
51Serotonergic synapse_Homo sapiens_hsa047260.86519450
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86202188
53Gastric acid secretion_Homo sapiens_hsa049710.83102540
54Homologous recombination_Homo sapiens_hsa034400.81949228
55Vibrio cholerae infection_Homo sapiens_hsa051100.79622693
56Phagosome_Homo sapiens_hsa041450.79090325
57Hippo signaling pathway_Homo sapiens_hsa043900.77404283
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76117910
59ABC transporters_Homo sapiens_hsa020100.74913831
60TGF-beta signaling pathway_Homo sapiens_hsa043500.72247518
61Butanoate metabolism_Homo sapiens_hsa006500.72019164
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71593318
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71255168
64Focal adhesion_Homo sapiens_hsa045100.71109251
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.71008091
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68988009
67Glycerolipid metabolism_Homo sapiens_hsa005610.68350569
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67271753
69Malaria_Homo sapiens_hsa051440.66588854
70Pertussis_Homo sapiens_hsa051330.65188748
71Metabolic pathways_Homo sapiens_hsa011000.64033657
72Olfactory transduction_Homo sapiens_hsa047400.63963217
73Morphine addiction_Homo sapiens_hsa050320.63896146
74Insulin secretion_Homo sapiens_hsa049110.61855981
75Amoebiasis_Homo sapiens_hsa051460.61128233
76Tryptophan metabolism_Homo sapiens_hsa003800.61023111
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59361286
78African trypanosomiasis_Homo sapiens_hsa051430.58739389
79Prion diseases_Homo sapiens_hsa050200.58561575
80Renin secretion_Homo sapiens_hsa049240.58320580
81Rap1 signaling pathway_Homo sapiens_hsa040150.56746284
82Cardiac muscle contraction_Homo sapiens_hsa042600.55593518
83Fatty acid degradation_Homo sapiens_hsa000710.54939803
84Axon guidance_Homo sapiens_hsa043600.54710709
85Hepatitis C_Homo sapiens_hsa051600.54453096
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54014272
87GABAergic synapse_Homo sapiens_hsa047270.53629606
88Peroxisome_Homo sapiens_hsa041460.51976798
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51913257
90Phenylalanine metabolism_Homo sapiens_hsa003600.51906484
91Melanoma_Homo sapiens_hsa052180.50353225
92Parkinsons disease_Homo sapiens_hsa050120.50323127
93RNA polymerase_Homo sapiens_hsa030200.49679566
94Galactose metabolism_Homo sapiens_hsa000520.49480978
95TNF signaling pathway_Homo sapiens_hsa046680.49412297
96Calcium signaling pathway_Homo sapiens_hsa040200.49308424
97Steroid biosynthesis_Homo sapiens_hsa001000.47875164
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47394291
99Glutamatergic synapse_Homo sapiens_hsa047240.47357638
100Taste transduction_Homo sapiens_hsa047420.46712436
101Hedgehog signaling pathway_Homo sapiens_hsa043400.44539431
102Proteoglycans in cancer_Homo sapiens_hsa052050.44486814
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44472819
104Thyroid hormone synthesis_Homo sapiens_hsa049180.44204104
105Purine metabolism_Homo sapiens_hsa002300.44177166
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43957777
107Type I diabetes mellitus_Homo sapiens_hsa049400.41481052
108Arginine and proline metabolism_Homo sapiens_hsa003300.41459093
109Cocaine addiction_Homo sapiens_hsa050300.41441690
110Circadian entrainment_Homo sapiens_hsa047130.41439380
111Circadian rhythm_Homo sapiens_hsa047100.41297831
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41137117
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41074552
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39072042
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38664865
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.38344175
117Bile secretion_Homo sapiens_hsa049760.38297093
118Small cell lung cancer_Homo sapiens_hsa052220.37681909
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37310484
120RNA degradation_Homo sapiens_hsa030180.37065305
121Complement and coagulation cascades_Homo sapiens_hsa046100.36812010
122Fat digestion and absorption_Homo sapiens_hsa049750.36558801
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36535417
124Notch signaling pathway_Homo sapiens_hsa043300.35622964
125Toxoplasmosis_Homo sapiens_hsa051450.34345566
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33807792
127Arachidonic acid metabolism_Homo sapiens_hsa005900.33642556
128Platelet activation_Homo sapiens_hsa046110.33604388
129Fatty acid metabolism_Homo sapiens_hsa012120.33573811
130Salivary secretion_Homo sapiens_hsa049700.33157473
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33089179
132Pathways in cancer_Homo sapiens_hsa052000.32324472
133PPAR signaling pathway_Homo sapiens_hsa033200.31834677
134Amphetamine addiction_Homo sapiens_hsa050310.31678172
135Tyrosine metabolism_Homo sapiens_hsa003500.30675564
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30655661
137cAMP signaling pathway_Homo sapiens_hsa040240.29838176
138Asthma_Homo sapiens_hsa053100.29814291
139Dopaminergic synapse_Homo sapiens_hsa047280.29563666
140Prostate cancer_Homo sapiens_hsa052150.29239089
141Alzheimers disease_Homo sapiens_hsa050100.28977480
142Insulin resistance_Homo sapiens_hsa049310.28894612
143Bladder cancer_Homo sapiens_hsa052190.27965304
144Endometrial cancer_Homo sapiens_hsa052130.27421517
145Dorso-ventral axis formation_Homo sapiens_hsa043200.27357527
146Nucleotide excision repair_Homo sapiens_hsa034200.27161211
147Graft-versus-host disease_Homo sapiens_hsa053320.26597486
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25669279
149Dilated cardiomyopathy_Homo sapiens_hsa054140.25368321
150Fatty acid biosynthesis_Homo sapiens_hsa000610.24770356
151Influenza A_Homo sapiens_hsa051640.23698368
152Intestinal immune network for IgA production_Homo sapiens_hsa046720.22801813
153Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22341668
154FoxO signaling pathway_Homo sapiens_hsa040680.21699059
155Renal cell carcinoma_Homo sapiens_hsa052110.21691198
156Lysosome_Homo sapiens_hsa041420.21236108
157Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20156371
158Ovarian steroidogenesis_Homo sapiens_hsa049130.19479870
159Salmonella infection_Homo sapiens_hsa051320.19384732
160PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18303625

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