

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | axon ensheathment in central nervous system (GO:0032291) | 6.72213198 |
| 2 | central nervous system myelination (GO:0022010) | 6.72213198 |
| 3 | neuronal action potential propagation (GO:0019227) | 5.39997105 |
| 4 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.81208599 |
| 5 | synaptic vesicle maturation (GO:0016188) | 4.43143332 |
| 6 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 4.37711937 |
| 7 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.33294325 |
| 8 | ensheathment of neurons (GO:0007272) | 4.28784452 |
| 9 | axon ensheathment (GO:0008366) | 4.28784452 |
| 10 | myelination (GO:0042552) | 4.21516581 |
| 11 | sensory perception of smell (GO:0007608) | 4.19212794 |
| 12 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.13992351 |
| 13 | neuromuscular process controlling posture (GO:0050884) | 4.10081454 |
| 14 | regulation of synapse structural plasticity (GO:0051823) | 4.05965257 |
| 15 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.93453433 |
| 16 | glycine transport (GO:0015816) | 3.93287883 |
| 17 | L-amino acid import (GO:0043092) | 3.88902705 |
| 18 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.87211476 |
| 19 | neuronal ion channel clustering (GO:0045161) | 3.84890080 |
| 20 | regulation of neurotransmitter secretion (GO:0046928) | 3.77157377 |
| 21 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.77088736 |
| 22 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.72631716 |
| 23 | adult walking behavior (GO:0007628) | 3.68982047 |
| 24 | neurotransmitter uptake (GO:0001504) | 3.68908506 |
| 25 | sodium ion export (GO:0071436) | 3.67264229 |
| 26 | regulation of neurotransmitter transport (GO:0051588) | 3.67127683 |
| 27 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.59687171 |
| 28 | synaptic vesicle exocytosis (GO:0016079) | 3.59225986 |
| 29 | positive regulation of synapse maturation (GO:0090129) | 3.58318831 |
| 30 | locomotory exploration behavior (GO:0035641) | 3.58143953 |
| 31 | cerebellar granule cell differentiation (GO:0021707) | 3.57123514 |
| 32 | regulation of neurotransmitter levels (GO:0001505) | 3.53711002 |
| 33 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.52372450 |
| 34 | postsynaptic membrane organization (GO:0001941) | 3.50546350 |
| 35 | exploration behavior (GO:0035640) | 3.49108232 |
| 36 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.48762500 |
| 37 | transmission of nerve impulse (GO:0019226) | 3.47373250 |
| 38 | myelin maintenance (GO:0043217) | 3.46414921 |
| 39 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.44407739 |
| 40 | glutamate secretion (GO:0014047) | 3.44302628 |
| 41 | cellular potassium ion homeostasis (GO:0030007) | 3.42025006 |
| 42 | potassium ion import (GO:0010107) | 3.37980408 |
| 43 | regulation of female receptivity (GO:0045924) | 3.34641778 |
| 44 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.31739398 |
| 45 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.30769863 |
| 46 | proline transport (GO:0015824) | 3.29291585 |
| 47 | positive regulation of neurotransmitter transport (GO:0051590) | 3.28384936 |
| 48 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.27991337 |
| 49 | vesicle docking involved in exocytosis (GO:0006904) | 3.27890661 |
| 50 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.25388191 |
| 51 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 3.25056963 |
| 52 | serotonin metabolic process (GO:0042428) | 3.24368595 |
| 53 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.22267978 |
| 54 | vocalization behavior (GO:0071625) | 3.21078960 |
| 55 | layer formation in cerebral cortex (GO:0021819) | 3.20749518 |
| 56 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 3.20500787 |
| 57 | membrane depolarization during action potential (GO:0086010) | 3.19680426 |
| 58 | acidic amino acid transport (GO:0015800) | 3.18883820 |
| 59 | prepulse inhibition (GO:0060134) | 3.17706373 |
| 60 | neuromuscular synaptic transmission (GO:0007274) | 3.17042719 |
| 61 | gamma-aminobutyric acid transport (GO:0015812) | 3.16953888 |
| 62 | regulation of postsynaptic membrane potential (GO:0060078) | 3.16103801 |
| 63 | negative regulation of protein localization to cell surface (GO:2000009) | 3.14714858 |
| 64 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.14490613 |
| 65 | creatine metabolic process (GO:0006600) | 3.14012934 |
| 66 | neuromuscular process controlling balance (GO:0050885) | 3.13922358 |
| 67 | detection of calcium ion (GO:0005513) | 3.13903344 |
| 68 | long-term synaptic potentiation (GO:0060291) | 3.13342254 |
| 69 | synaptic vesicle endocytosis (GO:0048488) | 3.12867422 |
| 70 | dendritic spine morphogenesis (GO:0060997) | 3.11621733 |
| 71 | regulation of synaptic vesicle transport (GO:1902803) | 3.10466210 |
| 72 | regulation of cell communication by electrical coupling (GO:0010649) | 3.09263386 |
| 73 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.08687617 |
| 74 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.08408668 |
| 75 | mating behavior (GO:0007617) | 3.07268154 |
| 76 | membrane tubulation (GO:0097320) | 3.06768963 |
| 77 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 3.02043737 |
| 78 | substrate-independent telencephalic tangential migration (GO:0021826) | 3.02043737 |
| 79 | cell communication by electrical coupling (GO:0010644) | 3.01593684 |
| 80 | neuron-neuron synaptic transmission (GO:0007270) | 3.00931792 |
| 81 | regulation of synapse maturation (GO:0090128) | 3.00811091 |
| 82 | vesicle docking (GO:0048278) | 3.00719831 |
| 83 | primary amino compound metabolic process (GO:1901160) | 2.99999114 |
| 84 | negative regulation of neurotransmitter transport (GO:0051589) | 2.99614619 |
| 85 | neurotransmitter secretion (GO:0007269) | 2.97603543 |
| 86 | regulation of glutamate receptor signaling pathway (GO:1900449) | 2.96702079 |
| 87 | positive regulation of dendritic spine development (GO:0060999) | 2.96373217 |
| 88 | activation of protein kinase A activity (GO:0034199) | 2.96180009 |
| 89 | fatty acid elongation (GO:0030497) | 2.96162584 |
| 90 | regulation of sodium ion transmembrane transporter activity (GO:2000649) | 2.95964470 |
| 91 | phosphorelay signal transduction system (GO:0000160) | 2.95952454 |
| 92 | potassium ion homeostasis (GO:0055075) | 2.95563047 |
| 93 | synaptic transmission, dopaminergic (GO:0001963) | 2.94516555 |
| 94 | synaptic transmission (GO:0007268) | 2.94469285 |
| 95 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 2.93807363 |
| 96 | regulation of synaptic transmission (GO:0050804) | 2.92834387 |
| 97 | negative regulation of neurotransmitter secretion (GO:0046929) | 2.92404303 |
| 98 | behavioral response to cocaine (GO:0048148) | 2.92128368 |
| 99 | long-term memory (GO:0007616) | 2.91353128 |
| 100 | auditory behavior (GO:0031223) | 2.91026766 |
| 101 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.90593748 |
| 102 | L-glutamate transport (GO:0015813) | 2.90481313 |
| 103 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.90289381 |
| 104 | potassium ion transmembrane transport (GO:0071805) | 2.89544502 |
| 105 | cellular potassium ion transport (GO:0071804) | 2.89544502 |
| 106 | neuron cell-cell adhesion (GO:0007158) | 2.88626876 |
| 107 | dendrite morphogenesis (GO:0048813) | 2.84763240 |
| 108 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.83840122 |
| 109 | nerve growth factor signaling pathway (GO:0038180) | 2.83523115 |
| 110 | positive regulation of potassium ion transport (GO:0043268) | 2.83146638 |
| 111 | negative regulation of heart rate (GO:0010459) | 2.81211515 |
| 112 | amino acid import (GO:0043090) | 2.81054207 |
| 113 | establishment of mitochondrion localization (GO:0051654) | 2.80497325 |
| 114 | striatum development (GO:0021756) | 2.80150035 |
| 115 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.79268595 |
| 116 | regulation of exocytosis (GO:0017157) | 2.78624681 |
| 117 | membrane hyperpolarization (GO:0060081) | 2.78368592 |
| 118 | regulation of sodium ion transmembrane transport (GO:1902305) | 2.77854309 |
| 119 | protein localization to synapse (GO:0035418) | 2.77264748 |
| 120 | response to auditory stimulus (GO:0010996) | 2.77103514 |
| 121 | presynaptic membrane assembly (GO:0097105) | 2.75820140 |
| 122 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.75516138 |
| 123 | long-chain fatty acid biosynthetic process (GO:0042759) | 2.75119595 |
| 124 | regulation of dendritic spine development (GO:0060998) | 2.75108531 |
| 125 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 2.74975911 |
| 126 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.74348353 |
| 127 | regulation of membrane repolarization (GO:0060306) | 2.73763561 |
| 128 | cyclic nucleotide catabolic process (GO:0009214) | 2.73160300 |
| 129 | synaptic transmission, glutamatergic (GO:0035249) | 2.70722014 |
| 130 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.70614077 |
| 131 | neuron recognition (GO:0008038) | 2.70559635 |
| 132 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.69987411 |
| 133 | regulation of synaptic plasticity (GO:0048167) | 2.69243892 |
| 134 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.68977422 |
| 135 | neurotransmitter transport (GO:0006836) | 2.67100299 |
| 136 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 2.66494299 |
| 137 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.65943231 |
| 138 | import into cell (GO:0098657) | 2.65265762 |
| 139 | myelination in peripheral nervous system (GO:0022011) | 2.64463083 |
| 140 | peripheral nervous system axon ensheathment (GO:0032292) | 2.64463083 |
| 141 | glutamate receptor signaling pathway (GO:0007215) | 2.63573227 |
| 142 | presynaptic membrane organization (GO:0097090) | 2.60076234 |
| 143 | membrane depolarization (GO:0051899) | 2.60051023 |
| 144 | vesicle transport along microtubule (GO:0047496) | 2.59988946 |
| 145 | regulation of neurotransmitter uptake (GO:0051580) | 2.59279742 |
| 146 | positive regulation of membrane potential (GO:0045838) | 2.58998389 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.95656660 |
| 2 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.84601400 |
| 3 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.74405799 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.62642824 |
| 5 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.58767997 |
| 6 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.58128628 |
| 7 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.48114981 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.48067076 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.48067076 |
| 10 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.38854055 |
| 11 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.38683953 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.19512757 |
| 13 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.15643816 |
| 14 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.13367220 |
| 15 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.12072512 |
| 16 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.11322734 |
| 17 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.10649760 |
| 18 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.07635764 |
| 19 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.05469627 |
| 20 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.00143721 |
| 21 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.94007420 |
| 22 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.89369436 |
| 23 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.88675538 |
| 24 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.85256582 |
| 25 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.79778282 |
| 26 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.61991843 |
| 27 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.57130413 |
| 28 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.52477149 |
| 29 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.52029386 |
| 30 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.48364226 |
| 31 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.47447040 |
| 32 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.44854615 |
| 33 | KDM2B_26808549_Chip-Seq_K562_Human | 1.42609278 |
| 34 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.42499461 |
| 35 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.42419633 |
| 36 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.38663115 |
| 37 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.37079877 |
| 38 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.36891197 |
| 39 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.36488524 |
| 40 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.35713343 |
| 41 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.33579529 |
| 42 | VDR_22108803_ChIP-Seq_LS180_Human | 1.31947030 |
| 43 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.29918584 |
| 44 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.29817118 |
| 45 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.29135193 |
| 46 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28985910 |
| 47 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.27579628 |
| 48 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.27127392 |
| 49 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.26263687 |
| 50 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.25390992 |
| 51 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.23384195 |
| 52 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.20475677 |
| 53 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.19068957 |
| 54 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.17998883 |
| 55 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.17872656 |
| 56 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.15830968 |
| 57 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.15052583 |
| 58 | AR_25329375_ChIP-Seq_VCAP_Human | 1.14256201 |
| 59 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.13445239 |
| 60 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.11923383 |
| 61 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.11435807 |
| 62 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.11241712 |
| 63 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.09734645 |
| 64 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.09364470 |
| 65 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.08536791 |
| 66 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.08478653 |
| 67 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.08074177 |
| 68 | AR_19668381_ChIP-Seq_PC3_Human | 1.08037339 |
| 69 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.08036640 |
| 70 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.07729700 |
| 71 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.07481077 |
| 72 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.06640888 |
| 73 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.06008698 |
| 74 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.05937513 |
| 75 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.05796310 |
| 76 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.05529149 |
| 77 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.05176020 |
| 78 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.04274088 |
| 79 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.03193253 |
| 80 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.03002766 |
| 81 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.02992788 |
| 82 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.02992788 |
| 83 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.02858128 |
| 84 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.01769929 |
| 85 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.01394718 |
| 86 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.00976583 |
| 87 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00743012 |
| 88 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.00357849 |
| 89 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.99909154 |
| 90 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.97852703 |
| 91 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.97809660 |
| 92 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.97042898 |
| 93 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.96846423 |
| 94 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.96633964 |
| 95 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.96554897 |
| 96 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.96483590 |
| 97 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.96036352 |
| 98 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.95861815 |
| 99 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.95263745 |
| 100 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.95173054 |
| 101 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.95013151 |
| 102 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.94547978 |
| 103 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.94291511 |
| 104 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.93476824 |
| 105 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.93380517 |
| 106 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.93340147 |
| 107 | * SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.93227395 |
| 108 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.93050485 |
| 109 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.92666497 |
| 110 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.92486305 |
| 111 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.92186425 |
| 112 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.92186425 |
| 113 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.91442673 |
| 114 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91232822 |
| 115 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.90724032 |
| 116 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.90608114 |
| 117 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.90208211 |
| 118 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.89674653 |
| 119 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.88734775 |
| 120 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88403125 |
| 121 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.88366072 |
| 122 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.88360420 |
| 123 | TCF4_23295773_ChIP-Seq_U87_Human | 0.88063500 |
| 124 | * KLF4_19829295_ChIP-Seq_ESCs_Human | 0.87632032 |
| 125 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.86270406 |
| 126 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.84774713 |
| 127 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.83954856 |
| 128 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.83670417 |
| 129 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.83312784 |
| 130 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.82736404 |
| 131 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.82576670 |
| 132 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.82098941 |
| 133 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.81485954 |
| 134 | P300_19829295_ChIP-Seq_ESCs_Human | 0.81432105 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.07242409 |
| 2 | MP0002822_catalepsy | 4.04123994 |
| 3 | MP0004270_analgesia | 3.88481435 |
| 4 | MP0003880_abnormal_central_pattern | 3.78497724 |
| 5 | MP0000920_abnormal_myelination | 3.31184255 |
| 6 | MP0003635_abnormal_synaptic_transmissio | 3.16374747 |
| 7 | MP0002064_seizures | 2.86037116 |
| 8 | MP0004145_abnormal_muscle_electrophysio | 2.83803153 |
| 9 | MP0002272_abnormal_nervous_system | 2.83656163 |
| 10 | MP0001486_abnormal_startle_reflex | 2.80021142 |
| 11 | MP0005423_abnormal_somatic_nervous | 2.79042380 |
| 12 | MP0009046_muscle_twitch | 2.59446670 |
| 13 | MP0001984_abnormal_olfaction | 2.59287950 |
| 14 | MP0009745_abnormal_behavioral_response | 2.56658375 |
| 15 | MP0002063_abnormal_learning/memory/cond | 2.39746454 |
| 16 | MP0000751_myopathy | 2.30168281 |
| 17 | MP0003329_amyloid_beta_deposits | 2.23477630 |
| 18 | MP0002734_abnormal_mechanical_nocicepti | 2.15855146 |
| 19 | MP0008569_lethality_at_weaning | 2.13844755 |
| 20 | MP0003787_abnormal_imprinting | 2.08773633 |
| 21 | MP0000749_muscle_degeneration | 2.08003222 |
| 22 | MP0004885_abnormal_endolymph | 1.99195238 |
| 23 | MP0003690_abnormal_glial_cell | 1.98893595 |
| 24 | MP0000747_muscle_weakness | 1.97174293 |
| 25 | MP0002572_abnormal_emotion/affect_behav | 1.88210692 |
| 26 | MP0001529_abnormal_vocalization | 1.82826079 |
| 27 | MP0004142_abnormal_muscle_tone | 1.78360594 |
| 28 | MP0003634_abnormal_glial_cell | 1.77972715 |
| 29 | MP0001968_abnormal_touch/_nociception | 1.72099452 |
| 30 | MP0008877_abnormal_DNA_methylation | 1.70349320 |
| 31 | MP0002067_abnormal_sensory_capabilities | 1.67796489 |
| 32 | MP0000778_abnormal_nervous_system | 1.65738767 |
| 33 | MP0000955_abnormal_spinal_cord | 1.62559225 |
| 34 | MP0005409_darkened_coat_color | 1.62041872 |
| 35 | MP0004036_abnormal_muscle_relaxation | 1.61341176 |
| 36 | MP0003633_abnormal_nervous_system | 1.56151704 |
| 37 | MP0001485_abnormal_pinna_reflex | 1.53438885 |
| 38 | MP0002229_neurodegeneration | 1.51921751 |
| 39 | MP0006276_abnormal_autonomic_nervous | 1.51417959 |
| 40 | MP0005386_behavior/neurological_phenoty | 1.49972521 |
| 41 | MP0004924_abnormal_behavior | 1.49972521 |
| 42 | MP0004811_abnormal_neuron_physiology | 1.48183614 |
| 43 | MP0003631_nervous_system_phenotype | 1.47931837 |
| 44 | MP0002882_abnormal_neuron_morphology | 1.45684808 |
| 45 | MP0002066_abnormal_motor_capabilities/c | 1.43076805 |
| 46 | MP0003632_abnormal_nervous_system | 1.40665193 |
| 47 | MP0001970_abnormal_pain_threshold | 1.40115632 |
| 48 | MP0005646_abnormal_pituitary_gland | 1.39836493 |
| 49 | MP0000569_abnormal_digit_pigmentation | 1.38819514 |
| 50 | MP0001905_abnormal_dopamine_level | 1.35663614 |
| 51 | MP0001440_abnormal_grooming_behavior | 1.32676644 |
| 52 | MP0002733_abnormal_thermal_nociception | 1.31418626 |
| 53 | MP0002184_abnormal_innervation | 1.30737826 |
| 54 | MP0004742_abnormal_vestibular_system | 1.30204362 |
| 55 | MP0002638_abnormal_pupillary_reflex | 1.29587130 |
| 56 | MP0001501_abnormal_sleep_pattern | 1.29520559 |
| 57 | MP0004043_abnormal_pH_regulation | 1.28457412 |
| 58 | MP0005623_abnormal_meninges_morphology | 1.23174481 |
| 59 | MP0005464_abnormal_platelet_physiology | 1.22095038 |
| 60 | MP0004233_abnormal_muscle_weight | 1.21893546 |
| 61 | MP0002557_abnormal_social/conspecific_i | 1.21627591 |
| 62 | MP0003646_muscle_fatigue | 1.17604046 |
| 63 | MP0002909_abnormal_adrenal_gland | 1.15707312 |
| 64 | MP0001986_abnormal_taste_sensitivity | 1.15458738 |
| 65 | MP0003136_yellow_coat_color | 1.14936869 |
| 66 | MP0004215_abnormal_myocardial_fiber | 1.13607129 |
| 67 | MP0002653_abnormal_ependyma_morphology | 1.12553089 |
| 68 | MP0003950_abnormal_plasma_membrane | 1.12085076 |
| 69 | MP0001299_abnormal_eye_distance/ | 1.09621537 |
| 70 | MP0000013_abnormal_adipose_tissue | 1.09611663 |
| 71 | MP0002269_muscular_atrophy | 1.06718508 |
| 72 | MP0005620_abnormal_muscle_contractility | 1.04517736 |
| 73 | MP0000759_abnormal_skeletal_muscle | 1.04076149 |
| 74 | MP0004087_abnormal_muscle_fiber | 1.04061641 |
| 75 | MP0009780_abnormal_chondrocyte_physiolo | 1.02108489 |
| 76 | MP0002106_abnormal_muscle_physiology | 1.01220776 |
| 77 | MP0004858_abnormal_nervous_system | 0.99957883 |
| 78 | MP0000604_amyloidosis | 0.98077606 |
| 79 | MP0005551_abnormal_eye_electrophysiolog | 0.96023962 |
| 80 | MP0003075_altered_response_to | 0.95657597 |
| 81 | MP0001177_atelectasis | 0.95545951 |
| 82 | MP0005167_abnormal_blood-brain_barrier | 0.93829073 |
| 83 | MP0002752_abnormal_somatic_nervous | 0.93654475 |
| 84 | MP0010386_abnormal_urinary_bladder | 0.93366919 |
| 85 | MP0002152_abnormal_brain_morphology | 0.93243290 |
| 86 | MP0005369_muscle_phenotype | 0.92589493 |
| 87 | MP0003137_abnormal_impulse_conducting | 0.90721190 |
| 88 | MP0005171_absent_coat_pigmentation | 0.90117439 |
| 89 | MP0004085_abnormal_heartbeat | 0.89136495 |
| 90 | MP0004484_altered_response_of | 0.88754101 |
| 91 | MP0008260_abnormal_autophagy | 0.86376559 |
| 92 | MP0005645_abnormal_hypothalamus_physiol | 0.85255312 |
| 93 | MP0000003_abnormal_adipose_tissue | 0.85111088 |
| 94 | MP0005410_abnormal_fertilization | 0.82609046 |
| 95 | MP0005394_taste/olfaction_phenotype | 0.82404852 |
| 96 | MP0005499_abnormal_olfactory_system | 0.82404852 |
| 97 | MP0005535_abnormal_body_temperature | 0.81901526 |
| 98 | MP0002736_abnormal_nociception_after | 0.81508342 |
| 99 | MP0001502_abnormal_circadian_rhythm | 0.81024505 |
| 100 | MP0002837_dystrophic_cardiac_calcinosis | 0.80871540 |
| 101 | MP0002876_abnormal_thyroid_physiology | 0.79899534 |
| 102 | MP0004510_myositis | 0.77497988 |
| 103 | MP0001963_abnormal_hearing_physiology | 0.76659423 |
| 104 | MP0008874_decreased_physiological_sensi | 0.76555942 |
| 105 | MP0003045_fibrosis | 0.75323180 |
| 106 | MP0004130_abnormal_muscle_cell | 0.75204526 |
| 107 | MP0001188_hyperpigmentation | 0.74920318 |
| 108 | MP0010678_abnormal_skin_adnexa | 0.73906530 |
| 109 | MP0000230_abnormal_systemic_arterial | 0.73101440 |
| 110 | MP0004084_abnormal_cardiac_muscle | 0.72255597 |
| 111 | MP0000383_abnormal_hair_follicle | 0.71302067 |
| 112 | MP0003122_maternal_imprinting | 0.70439421 |
| 113 | MP0003879_abnormal_hair_cell | 0.67991540 |
| 114 | MP0002735_abnormal_chemical_nociception | 0.67309589 |
| 115 | MP0001765_abnormal_ion_homeostasis | 0.66572498 |
| 116 | MP0004147_increased_porphyrin_level | 0.65167032 |
| 117 | MP0008004_abnormal_stomach_pH | 0.64099341 |
| 118 | MP0008872_abnormal_physiological_respon | 0.64013149 |
| 119 | MP0002108_abnormal_muscle_morphology | 0.63899604 |
| 120 | MP0005253_abnormal_eye_physiology | 0.63836919 |
| 121 | MP0003172_abnormal_lysosome_physiology | 0.62727402 |
| 122 | MP0002069_abnormal_eating/drinking_beha | 0.61830167 |
| 123 | MP0000631_abnormal_neuroendocrine_gland | 0.60162355 |
| 124 | MP0003283_abnormal_digestive_organ | 0.58923147 |
| 125 | MP0008775_abnormal_heart_ventricle | 0.57765048 |
| 126 | MP0005174_abnormal_tail_pigmentation | 0.56136776 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 5.34311252 |
| 2 | Termporal pattern (HP:0011008) | 5.01192758 |
| 3 | Insidious onset (HP:0003587) | 5.01192758 |
| 4 | Action tremor (HP:0002345) | 4.81862403 |
| 5 | Diplopia (HP:0000651) | 4.59194662 |
| 6 | Abnormality of binocular vision (HP:0011514) | 4.59194662 |
| 7 | Focal motor seizures (HP:0011153) | 4.57371422 |
| 8 | Exercise-induced myalgia (HP:0003738) | 4.42585609 |
| 9 | Peripheral hypomyelination (HP:0007182) | 4.37126315 |
| 10 | Onion bulb formation (HP:0003383) | 4.08281820 |
| 11 | Supranuclear gaze palsy (HP:0000605) | 3.85978161 |
| 12 | Focal seizures (HP:0007359) | 3.83840241 |
| 13 | Neurofibrillary tangles (HP:0002185) | 3.83141886 |
| 14 | Ulnar claw (HP:0001178) | 3.81436439 |
| 15 | Ankle clonus (HP:0011448) | 3.79946619 |
| 16 | Segmental peripheral demyelination/remyelination (HP:0003481) | 3.65669916 |
| 17 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 3.49542599 |
| 18 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 3.49542599 |
| 19 | Difficulty running (HP:0009046) | 3.43018612 |
| 20 | Muscle fiber inclusion bodies (HP:0100299) | 3.39223849 |
| 21 | Muscle hypertrophy of the lower extremities (HP:0008968) | 3.34356327 |
| 22 | Exercise-induced muscle cramps (HP:0003710) | 3.26926422 |
| 23 | Abnormality of the corticospinal tract (HP:0002492) | 3.21975213 |
| 24 | Hemiparesis (HP:0001269) | 3.21499397 |
| 25 | Spastic gait (HP:0002064) | 3.21467558 |
| 26 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 3.19983454 |
| 27 | Intention tremor (HP:0002080) | 3.17948882 |
| 28 | Bundle branch block (HP:0011710) | 3.14064553 |
| 29 | Papilledema (HP:0001085) | 3.11890751 |
| 30 | Dysmetria (HP:0001310) | 3.11760632 |
| 31 | Hemiplegia (HP:0002301) | 3.10933648 |
| 32 | Abnormal eating behavior (HP:0100738) | 3.10026134 |
| 33 | Foot dorsiflexor weakness (HP:0009027) | 3.09817726 |
| 34 | Nemaline bodies (HP:0003798) | 3.04672147 |
| 35 | Cerebral inclusion bodies (HP:0100314) | 3.03008334 |
| 36 | Urinary urgency (HP:0000012) | 2.96667484 |
| 37 | Atonic seizures (HP:0010819) | 2.93844922 |
| 38 | Abnormality of the foot musculature (HP:0001436) | 2.90457620 |
| 39 | Calf muscle hypertrophy (HP:0008981) | 2.86958892 |
| 40 | Hammertoe (HP:0001765) | 2.82882611 |
| 41 | Generalized tonic-clonic seizures (HP:0002069) | 2.82249448 |
| 42 | Hyporeflexia of lower limbs (HP:0002600) | 2.81328049 |
| 43 | Prolonged bleeding time (HP:0003010) | 2.74156157 |
| 44 | Epileptiform EEG discharges (HP:0011182) | 2.71781174 |
| 45 | Muscle fiber splitting (HP:0003555) | 2.70213946 |
| 46 | Cerebral hypomyelination (HP:0006808) | 2.60941707 |
| 47 | Clumsiness (HP:0002312) | 2.60781820 |
| 48 | Broad-based gait (HP:0002136) | 2.60465755 |
| 49 | Scanning speech (HP:0002168) | 2.60280457 |
| 50 | Tetraplegia (HP:0002445) | 2.59870277 |
| 51 | Muscle stiffness (HP:0003552) | 2.59539756 |
| 52 | Visual hallucinations (HP:0002367) | 2.58379052 |
| 53 | Pheochromocytoma (HP:0002666) | 2.56933683 |
| 54 | Torticollis (HP:0000473) | 2.52542086 |
| 55 | Prolonged QT interval (HP:0001657) | 2.52392221 |
| 56 | Status epilepticus (HP:0002133) | 2.51430510 |
| 57 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.51264236 |
| 58 | Depression (HP:0000716) | 2.46839081 |
| 59 | Dialeptic seizures (HP:0011146) | 2.44163618 |
| 60 | Menorrhagia (HP:0000132) | 2.43082963 |
| 61 | Lower limb muscle weakness (HP:0007340) | 2.41839087 |
| 62 | Steppage gait (HP:0003376) | 2.39703944 |
| 63 | Delusions (HP:0000746) | 2.39696914 |
| 64 | Febrile seizures (HP:0002373) | 2.39690891 |
| 65 | Abnormal auditory evoked potentials (HP:0006958) | 2.39174059 |
| 66 | EEG with generalized epileptiform discharges (HP:0011198) | 2.38435327 |
| 67 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.38090715 |
| 68 | Decreased motor nerve conduction velocity (HP:0003431) | 2.37827650 |
| 69 | Epileptic encephalopathy (HP:0200134) | 2.36447787 |
| 70 | Dysdiadochokinesis (HP:0002075) | 2.36186892 |
| 71 | Mutism (HP:0002300) | 2.35654666 |
| 72 | Retinal dysplasia (HP:0007973) | 2.34382174 |
| 73 | Anxiety (HP:0000739) | 2.34268521 |
| 74 | Absence seizures (HP:0002121) | 2.34149398 |
| 75 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.32557894 |
| 76 | Genetic anticipation (HP:0003743) | 2.29380276 |
| 77 | Impaired vibratory sensation (HP:0002495) | 2.29094976 |
| 78 | Poor eye contact (HP:0000817) | 2.29076518 |
| 79 | Hypsarrhythmia (HP:0002521) | 2.27919492 |
| 80 | Postural instability (HP:0002172) | 2.26915476 |
| 81 | Increased circulating renin level (HP:0000848) | 2.26096326 |
| 82 | Increased variability in muscle fiber diameter (HP:0003557) | 2.26044781 |
| 83 | Bradykinesia (HP:0002067) | 2.25715953 |
| 84 | Hyperventilation (HP:0002883) | 2.23594596 |
| 85 | Type 1 muscle fiber predominance (HP:0003803) | 2.23277252 |
| 86 | Megalencephaly (HP:0001355) | 2.20495697 |
| 87 | Postural tremor (HP:0002174) | 2.19885176 |
| 88 | Heart block (HP:0012722) | 2.18818405 |
| 89 | Clonus (HP:0002169) | 2.16569367 |
| 90 | Impaired smooth pursuit (HP:0007772) | 2.16358320 |
| 91 | Polyphagia (HP:0002591) | 2.16156147 |
| 92 | Absent speech (HP:0001344) | 2.15052878 |
| 93 | Craniofacial dystonia (HP:0012179) | 2.14324754 |
| 94 | EMG: myopathic abnormalities (HP:0003458) | 2.13909814 |
| 95 | Myopathic facies (HP:0002058) | 2.13845505 |
| 96 | Decreased central vision (HP:0007663) | 2.13656185 |
| 97 | Focal dystonia (HP:0004373) | 2.12679022 |
| 98 | Ventricular fibrillation (HP:0001663) | 2.12591128 |
| 99 | Distal sensory impairment (HP:0002936) | 2.11522409 |
| 100 | Decreased number of peripheral myelinated nerve fibers (HP:0003380) | 2.11109706 |
| 101 | Neuroendocrine neoplasm (HP:0100634) | 2.09853365 |
| 102 | Truncal ataxia (HP:0002078) | 2.09269332 |
| 103 | Rapidly progressive (HP:0003678) | 2.08645437 |
| 104 | Impaired social interactions (HP:0000735) | 2.07065138 |
| 105 | Abnormal social behavior (HP:0012433) | 2.07065138 |
| 106 | Progressive cerebellar ataxia (HP:0002073) | 2.04113633 |
| 107 | Myotonia (HP:0002486) | 2.04050029 |
| 108 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.03169218 |
| 109 | Spastic tetraparesis (HP:0001285) | 2.03015536 |
| 110 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.02076226 |
| 111 | Achilles tendon contracture (HP:0001771) | 2.02072944 |
| 112 | Choreoathetosis (HP:0001266) | 2.02068010 |
| 113 | Akinesia (HP:0002304) | 2.00852709 |
| 114 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.99424238 |
| 115 | Rigidity (HP:0002063) | 1.98840652 |
| 116 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.98532573 |
| 117 | Slow progression (HP:0003677) | 1.98324467 |
| 118 | Abnormality of the calf musculature (HP:0001430) | 1.98260724 |
| 119 | Obstructive sleep apnea (HP:0002870) | 1.98224850 |
| 120 | Round ear (HP:0100830) | 1.97358309 |
| 121 | Syncope (HP:0001279) | 1.96625363 |
| 122 | Abnormal EKG (HP:0003115) | 1.95778311 |
| 123 | Distal arthrogryposis (HP:0005684) | 1.95478928 |
| 124 | Increased mean platelet volume (HP:0011877) | 1.95366238 |
| 125 | Neuronal loss in central nervous system (HP:0002529) | 1.95173996 |
| 126 | Axonal loss (HP:0003447) | 1.94701706 |
| 127 | Sensory axonal neuropathy (HP:0003390) | 1.93968783 |
| 128 | Gaze-evoked nystagmus (HP:0000640) | 1.92562604 |
| 129 | Lower limb amyotrophy (HP:0007210) | 1.91370925 |
| 130 | Dysphonia (HP:0001618) | 1.91092738 |
| 131 | Petechiae (HP:0000967) | 1.90065964 |
| 132 | Limb dystonia (HP:0002451) | 1.89988314 |
| 133 | Bowel incontinence (HP:0002607) | 1.89676181 |
| 134 | Hyperlipoproteinemia (HP:0010980) | 1.89451546 |
| 135 | Purpura (HP:0000979) | 1.84087806 |
| 136 | Congenital stationary night blindness (HP:0007642) | 1.83458052 |
| 137 | Abnormal atrioventricular conduction (HP:0005150) | 1.79606452 |
| 138 | Sleep apnea (HP:0010535) | 1.77989566 |
| 139 | Incomplete penetrance (HP:0003829) | 1.77955827 |
| 140 | CNS hypomyelination (HP:0003429) | 1.76789128 |
| 141 | Abnormal drinking behavior (HP:0030082) | 1.75991947 |
| 142 | Polydipsia (HP:0001959) | 1.75991947 |
| 143 | Fetal akinesia sequence (HP:0001989) | 1.73807625 |
| 144 | Stereotypic behavior (HP:0000733) | 1.71602720 |
| 145 | Abnormal platelet volume (HP:0011876) | 1.70689110 |
| 146 | Amblyopia (HP:0000646) | 1.65690366 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 3.46003223 |
| 2 | STK39 | 3.07334460 |
| 3 | NTRK3 | 2.76451369 |
| 4 | PHKG2 | 2.66946237 |
| 5 | PHKG1 | 2.66946237 |
| 6 | PAK6 | 2.46078918 |
| 7 | PRKD3 | 2.42896866 |
| 8 | OXSR1 | 2.42730878 |
| 9 | FRK | 2.39874814 |
| 10 | MAP3K9 | 2.16057456 |
| 11 | PRPF4B | 2.02192184 |
| 12 | TYRO3 | 1.98581939 |
| 13 | PLK2 | 1.96913300 |
| 14 | TNIK | 1.93650566 |
| 15 | OBSCN | 1.92008355 |
| 16 | DAPK2 | 1.90196808 |
| 17 | UHMK1 | 1.89346176 |
| 18 | KSR2 | 1.87451834 |
| 19 | NTRK1 | 1.83546284 |
| 20 | MARK1 | 1.83450061 |
| 21 | WNK1 | 1.81955817 |
| 22 | EPHB1 | 1.79337769 |
| 23 | PINK1 | 1.74680897 |
| 24 | CDK19 | 1.63590422 |
| 25 | MINK1 | 1.53535899 |
| 26 | NTRK2 | 1.51687775 |
| 27 | PKN1 | 1.47626953 |
| 28 | LIMK1 | 1.45099357 |
| 29 | CDK5 | 1.41509747 |
| 30 | CAMK2B | 1.40337190 |
| 31 | MAP3K4 | 1.33756639 |
| 32 | BMPR2 | 1.31666640 |
| 33 | MAPKAPK5 | 1.30178929 |
| 34 | MAP3K13 | 1.29347979 |
| 35 | SGK494 | 1.28972094 |
| 36 | SGK223 | 1.28972094 |
| 37 | CAMKK1 | 1.27733871 |
| 38 | BCR | 1.19703925 |
| 39 | FGFR2 | 1.19508145 |
| 40 | PAK3 | 1.18899264 |
| 41 | ICK | 1.18247766 |
| 42 | CAMK2D | 1.18074040 |
| 43 | SGK2 | 1.16005489 |
| 44 | NEK6 | 1.12470337 |
| 45 | CAMK2G | 1.09669884 |
| 46 | TTN | 1.09371868 |
| 47 | MAP3K7 | 1.07477560 |
| 48 | PNCK | 1.07371664 |
| 49 | MAP2K4 | 1.05267127 |
| 50 | WNK4 | 1.04570117 |
| 51 | TAOK3 | 1.03532866 |
| 52 | STK38 | 1.02818164 |
| 53 | ADRBK2 | 0.98122460 |
| 54 | ARAF | 0.97576033 |
| 55 | ROCK2 | 0.95487209 |
| 56 | MARK2 | 0.94893787 |
| 57 | MAPK12 | 0.92644160 |
| 58 | CSNK1G2 | 0.92249099 |
| 59 | DYRK1A | 0.90401357 |
| 60 | CDK15 | 0.89620856 |
| 61 | CDK18 | 0.86964480 |
| 62 | FES | 0.86752013 |
| 63 | TNK2 | 0.85583678 |
| 64 | CDK14 | 0.85157667 |
| 65 | MAP4K2 | 0.84371818 |
| 66 | PRKCH | 0.84050414 |
| 67 | CSNK1A1L | 0.83343818 |
| 68 | STK11 | 0.83122758 |
| 69 | SGK3 | 0.81417950 |
| 70 | CAMK2A | 0.80557248 |
| 71 | TXK | 0.79500910 |
| 72 | PDPK1 | 0.78748685 |
| 73 | CDK11A | 0.78320438 |
| 74 | PRKD1 | 0.78217489 |
| 75 | CAMKK2 | 0.77586399 |
| 76 | DMPK | 0.77003177 |
| 77 | GRK1 | 0.76831247 |
| 78 | CSNK1G3 | 0.73997299 |
| 79 | MAP2K7 | 0.73853572 |
| 80 | KSR1 | 0.73080740 |
| 81 | MAP3K2 | 0.71280404 |
| 82 | ERBB3 | 0.70699231 |
| 83 | TAOK1 | 0.70641617 |
| 84 | MET | 0.70352540 |
| 85 | MST4 | 0.69897715 |
| 86 | RET | 0.69538897 |
| 87 | MAPK13 | 0.68832532 |
| 88 | CAMK4 | 0.67709613 |
| 89 | NME1 | 0.66243781 |
| 90 | MAPK15 | 0.65343574 |
| 91 | LMTK2 | 0.64096303 |
| 92 | PRKCG | 0.63877551 |
| 93 | CAMK1G | 0.62329694 |
| 94 | PTK2B | 0.61214180 |
| 95 | FYN | 0.59878816 |
| 96 | SIK2 | 0.58581820 |
| 97 | MUSK | 0.56473501 |
| 98 | MAPKAPK3 | 0.54207742 |
| 99 | IRAK2 | 0.54160613 |
| 100 | MAPK10 | 0.54116591 |
| 101 | CASK | 0.53809031 |
| 102 | SGK1 | 0.53797248 |
| 103 | FGR | 0.53614481 |
| 104 | PDK1 | 0.52896190 |
| 105 | CAMK1 | 0.52691012 |
| 106 | PRKG1 | 0.52460701 |
| 107 | PRKCZ | 0.51569906 |
| 108 | CCNB1 | 0.51538420 |
| 109 | SYK | 0.51538253 |
| 110 | GRK5 | 0.51384528 |
| 111 | RPS6KA3 | 0.51360672 |
| 112 | CDC42BPA | 0.51103432 |
| 113 | BMX | 0.51083859 |
| 114 | RIPK4 | 0.50614896 |
| 115 | MAP3K1 | 0.50496071 |
| 116 | DAPK3 | 0.50339841 |
| 117 | PRKCA | 0.50047433 |
| 118 | CSNK1G1 | 0.48790652 |
| 119 | ALK | 0.47655948 |
| 120 | PRKACA | 0.47506737 |
| 121 | MAP2K1 | 0.45994345 |
| 122 | PRKCE | 0.45545538 |
| 123 | DAPK1 | 0.44313913 |
| 124 | ERBB2 | 0.42190177 |
| 125 | PIK3CG | 0.42107233 |
| 126 | PRKCQ | 0.41987218 |
| 127 | ADRBK1 | 0.41466561 |
| 128 | ROCK1 | 0.40188567 |
| 129 | STK24 | 0.39975526 |
| 130 | PRKCB | 0.39145083 |
| 131 | LATS2 | 0.36565820 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Olfactory transduction_Homo sapiens_hsa04740 | 3.89046061 |
| 2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.57797197 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.49148400 |
| 4 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.36325787 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.33905628 |
| 6 | Morphine addiction_Homo sapiens_hsa05032 | 2.19356550 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.13161009 |
| 8 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.99784777 |
| 9 | Nicotine addiction_Homo sapiens_hsa05033 | 1.94890562 |
| 10 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.85383573 |
| 11 | Long-term potentiation_Homo sapiens_hsa04720 | 1.81826948 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.79618847 |
| 13 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.77916374 |
| 14 | Salivary secretion_Homo sapiens_hsa04970 | 1.77516405 |
| 15 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.75724168 |
| 16 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.68735395 |
| 17 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.68672089 |
| 18 | Cocaine addiction_Homo sapiens_hsa05030 | 1.68520879 |
| 19 | Insulin secretion_Homo sapiens_hsa04911 | 1.60050290 |
| 20 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.58987690 |
| 21 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.55629889 |
| 22 | Renin secretion_Homo sapiens_hsa04924 | 1.49392927 |
| 23 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.46145442 |
| 24 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.45021351 |
| 25 | Long-term depression_Homo sapiens_hsa04730 | 1.43146270 |
| 26 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.42819824 |
| 27 | Axon guidance_Homo sapiens_hsa04360 | 1.40340764 |
| 28 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.37983948 |
| 29 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.37542899 |
| 30 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.30433920 |
| 31 | Gap junction_Homo sapiens_hsa04540 | 1.27814648 |
| 32 | Taste transduction_Homo sapiens_hsa04742 | 1.27620973 |
| 33 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.25213112 |
| 34 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.23071103 |
| 35 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.22612045 |
| 36 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.14174374 |
| 37 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.13325809 |
| 38 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.09369227 |
| 39 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.08325474 |
| 40 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.06905495 |
| 41 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.06870646 |
| 42 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.06410974 |
| 43 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.06306479 |
| 44 | Histidine metabolism_Homo sapiens_hsa00340 | 1.01809335 |
| 45 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.01279776 |
| 46 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.00904986 |
| 47 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.00615511 |
| 48 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.99831090 |
| 49 | Phototransduction_Homo sapiens_hsa04744 | 0.99277789 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.98697903 |
| 51 | Platelet activation_Homo sapiens_hsa04611 | 0.96625123 |
| 52 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.96455349 |
| 53 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.92811768 |
| 54 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.92800834 |
| 55 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.91366432 |
| 56 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.91242025 |
| 57 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.85080728 |
| 58 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.83595169 |
| 59 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.82105216 |
| 60 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.81837354 |
| 61 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.80394791 |
| 62 | Melanogenesis_Homo sapiens_hsa04916 | 0.79588063 |
| 63 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.78806626 |
| 64 | ABC transporters_Homo sapiens_hsa02010 | 0.77611938 |
| 65 | Tight junction_Homo sapiens_hsa04530 | 0.77174382 |
| 66 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.76178624 |
| 67 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.76161275 |
| 68 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.75573244 |
| 69 | Bile secretion_Homo sapiens_hsa04976 | 0.73097435 |
| 70 | Endocytosis_Homo sapiens_hsa04144 | 0.71345841 |
| 71 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.69972968 |
| 72 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.69620562 |
| 73 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.69190839 |
| 74 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.66135989 |
| 75 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.65533169 |
| 76 | Glioma_Homo sapiens_hsa05214 | 0.65225049 |
| 77 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.64616205 |
| 78 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.58330821 |
| 79 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.57013753 |
| 80 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.56829080 |
| 81 | Alcoholism_Homo sapiens_hsa05034 | 0.54904072 |
| 82 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.54427789 |
| 83 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.53289197 |
| 84 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.53205846 |
| 85 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.52333240 |
| 86 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.51593904 |
| 87 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.51289229 |
| 88 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.51058339 |
| 89 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.50638075 |
| 90 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.46639021 |
| 91 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.45559598 |
| 92 | Prion diseases_Homo sapiens_hsa05020 | 0.44053136 |
| 93 | Mineral absorption_Homo sapiens_hsa04978 | 0.43986853 |
| 94 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.43813457 |
| 95 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.43633497 |
| 96 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.40922731 |
| 97 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.40373256 |
| 98 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.39929391 |
| 99 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.39535771 |
| 100 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.39213852 |
| 101 | Alzheimers disease_Homo sapiens_hsa05010 | 0.38957785 |
| 102 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.38859499 |
| 103 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.37860951 |
| 104 | Circadian rhythm_Homo sapiens_hsa04710 | 0.37326719 |
| 105 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.36877982 |
| 106 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.36284612 |
| 107 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.34410138 |
| 108 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.33807079 |
| 109 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.33696258 |
| 110 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.32508548 |
| 111 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.32498249 |
| 112 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.32284754 |
| 113 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.32088922 |
| 114 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.25453706 |
| 115 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.22852949 |

