ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	hair cycle (GO:0042633)	6.04962096
2	molting cycle (GO:0042303)	6.04962096
3	behavioral response to nicotine (GO:0035095)	4.94870359
4	response to pheromone (GO:0019236)	4.13352197
5	fucose catabolic process (GO:0019317)	3.94760440
6	L-fucose metabolic process (GO:0042354)	3.94760440
7	L-fucose catabolic process (GO:0042355)	3.94760440
8	detection of light stimulus involved in visual perception (GO:0050908)	3.92470526
9	detection of light stimulus involved in sensory perception (GO:0050962)	3.92470526
10	tryptophan catabolic process (GO:0006569)	3.86700878
11	indole-containing compound catabolic process (GO:0042436)	3.86700878
12	indolalkylamine catabolic process (GO:0046218)	3.86700878
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.73904950
14	indolalkylamine metabolic process (GO:0006586)	3.68998384
15	fatty acid elongation (GO:0030497)	3.59624855
16	platelet dense granule organization (GO:0060155)	3.55960354
17	kynurenine metabolic process (GO:0070189)	3.55786401
18	tryptophan metabolic process (GO:0006568)	3.48043718
19	piRNA metabolic process (GO:0034587)	3.35965643
20	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.32443632
21	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.31949022
22	cellular ketone body metabolic process (GO:0046950)	3.21384461
23	DNA deamination (GO:0045006)	3.16356346
24	respiratory chain complex IV assembly (GO:0008535)	3.12679019
25	regulation of action potential (GO:0098900)	3.10072908
26	negative regulation of telomere maintenance (GO:0032205)	3.05258052
27	ketone body metabolic process (GO:1902224)	3.00908195
28	neural tube formation (GO:0001841)	2.98475021
29	photoreceptor cell maintenance (GO:0045494)	2.96092490
30	reflex (GO:0060004)	2.93826027
31	protein complex biogenesis (GO:0070271)	2.93264325
32	negative regulation of mast cell activation (GO:0033004)	2.92426195
33	axoneme assembly (GO:0035082)	2.91743962
34	water-soluble vitamin biosynthetic process (GO:0042364)	2.91234740
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.90988386
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.90988386
37	NADH dehydrogenase complex assembly (GO:0010257)	2.90988386
38	gamma-aminobutyric acid transport (GO:0015812)	2.90390354
39	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.89096209
40	indole-containing compound metabolic process (GO:0042430)	2.89085815
41	preassembly of GPI anchor in ER membrane (GO:0016254)	2.88758151
42	protein localization to cilium (GO:0061512)	2.87814001
43	neuronal action potential (GO:0019228)	2.87544846
44	DNA methylation involved in gamete generation (GO:0043046)	2.87439661
45	retinal cone cell development (GO:0046549)	2.87349117
46	kidney morphogenesis (GO:0060993)	2.85172858
47	regulation of cilium movement (GO:0003352)	2.83760379
48	epithelial cilium movement (GO:0003351)	2.82616811
49	behavioral response to ethanol (GO:0048149)	2.81924577
50	cornea development in camera-type eye (GO:0061303)	2.79661643
51	amine catabolic process (GO:0009310)	2.78705443
52	cellular biogenic amine catabolic process (GO:0042402)	2.78705443
53	multicellular organism reproduction (GO:0032504)	2.77976088
54	sulfation (GO:0051923)	2.77434366
55	protein K11-linked deubiquitination (GO:0035871)	2.76507696
56	rhodopsin mediated signaling pathway (GO:0016056)	2.76475999
57	nephron epithelium morphogenesis (GO:0072088)	2.74356818
58	nephron tubule morphogenesis (GO:0072078)	2.74356818
59	cytochrome complex assembly (GO:0017004)	2.73553139
60	nonmotile primary cilium assembly (GO:0035058)	2.72438117
61	cilium morphogenesis (GO:0060271)	2.68185436
62	mannosylation (GO:0097502)	2.68077874
63	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.65967389
64	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.65500041
65	mitochondrial respiratory chain complex assembly (GO:0033108)	2.65462958
66	regulation of hippo signaling (GO:0035330)	2.64003946
67	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.61693947
68	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.59575879
69	dopamine transport (GO:0015872)	2.56806385
70	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.55502024
71	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.55400480
72	photoreceptor cell development (GO:0042461)	2.55397216
73	protein-cofactor linkage (GO:0018065)	2.54164475
74	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.53115519
75	primary amino compound metabolic process (GO:1901160)	2.51506660
76	intermediate filament organization (GO:0045109)	2.50119060
77	protein polyglutamylation (GO:0018095)	2.50053837
78	signal peptide processing (GO:0006465)	2.49782238
79	benzene-containing compound metabolic process (GO:0042537)	2.49577860
80	keratinization (GO:0031424)	2.48949988
81	auditory receptor cell stereocilium organization (GO:0060088)	2.48467304
82	positive regulation of fatty acid transport (GO:2000193)	2.47211318
83	cilium organization (GO:0044782)	2.45051820
84	regulation of hexokinase activity (GO:1903299)	2.44558479
85	regulation of glucokinase activity (GO:0033131)	2.44558479
86	embryonic epithelial tube formation (GO:0001838)	2.41914231
87	regulation of neurotransmitter uptake (GO:0051580)	2.41844990
88	L-methionine salvage (GO:0071267)	2.40007602
89	L-methionine biosynthetic process (GO:0071265)	2.40007602
90	amino acid salvage (GO:0043102)	2.40007602
91	cilium assembly (GO:0042384)	2.38386344
92	serotonin metabolic process (GO:0042428)	2.37460361
93	glycerophospholipid catabolic process (GO:0046475)	2.37286557
94	synaptic transmission, cholinergic (GO:0007271)	2.36807424
95	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.36189791
96	aromatic amino acid family catabolic process (GO:0009074)	2.35605824
97	renal tubule morphogenesis (GO:0061333)	2.34562926
98	cilium movement (GO:0003341)	2.34303406
99	synapsis (GO:0007129)	2.34284678
100	male meiosis I (GO:0007141)	2.34274734

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.81237608
2	VDR_22108803_ChIP-Seq_LS180_Human	3.22835251
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.07387098
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.62865381
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59530346
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.53680961
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46341530
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.31808488
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.28422013
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20906773
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.16548289
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08833088
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.04403195
14	FUS_26573619_Chip-Seq_HEK293_Human	2.04141752
15	P300_19829295_ChIP-Seq_ESCs_Human	2.01623874
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98402762
17	EWS_26573619_Chip-Seq_HEK293_Human	1.94164844
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.85892598
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.81280505
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76948036
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.73871807
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.72623289
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70785270
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69761619
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67429963
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.66833438
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60637431
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.59087888
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.57940331
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.56230437
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56230437
32	STAT3_23295773_ChIP-Seq_U87_Human	1.54925059
33	AR_25329375_ChIP-Seq_VCAP_Human	1.54705082
34	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.54446615
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52168263
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49294273
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.47941189
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.47941189
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.45831889
40	TCF4_23295773_ChIP-Seq_U87_Human	1.45666305
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45025656
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44800551
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44474439
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44474439
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44139107
46	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.42992501
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42926905
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.42637757
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41112733
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41112733
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.40307016
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39331912
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.36272941
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36167647
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35013372
56	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34131978
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30184601
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30113247
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29642771
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28871630
61	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27927339
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27253103
63	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26408131
64	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26291981
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25240159
66	AR_21572438_ChIP-Seq_LNCaP_Human	1.25049681
67	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.24402758
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23919964
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21712868
70	NCOR_22424771_ChIP-Seq_293T_Human	1.19311794
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19017664
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17437328
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16800912
74	AR_20517297_ChIP-Seq_VCAP_Human	1.16601912
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14629753
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13132870
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12906084
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12471522
79	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12014521
80	CDX2_22108803_ChIP-Seq_LS180_Human	1.10882001
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10879960
82	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10248603
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10080508
84	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07036390
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06056668
86	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05887136
87	MYC_18940864_ChIP-ChIP_HL60_Human	1.02626552
88	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01272851
89	TP53_16413492_ChIP-PET_HCT116_Human	0.99834061
90	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98670132
91	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.98513983
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97762453
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97318734
94	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.97164849
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96564386
96	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96041685
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.95844855
98	ETV1_20927104_ChIP-Seq_GIST48_Human	0.94491087
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93231417
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.93104825

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.34827018
2	MP0000647_abnormal_sebaceous_gland	3.19778512
3	MP0000569_abnormal_digit_pigmentation	2.80124980
4	MP0008877_abnormal_DNA_methylation	2.58636107
5	MP0005551_abnormal_eye_electrophysiolog	2.55567042
6	MP0002102_abnormal_ear_morphology	2.53616740
7	MP0000427_abnormal_hair_cycle	2.37623874
8	MP0003136_yellow_coat_color	2.32911857
9	MP0004885_abnormal_endolymph	2.32090382
10	MP0003011_delayed_dark_adaptation	2.18062542
11	MP0001968_abnormal_touch/_nociception	2.15553946
12	MP0005174_abnormal_tail_pigmentation	2.14916607
13	MP0005075_abnormal_melanosome_morpholog	2.11324768
14	MP0002837_dystrophic_cardiac_calcinosis	2.03937428
15	MP0004381_abnormal_hair_follicle	2.03724170
16	MP0000383_abnormal_hair_follicle	2.03036819
17	MP0006072_abnormal_retinal_apoptosis	1.98035490
18	MP0009046_muscle_twitch	1.97047578
19	MP0002095_abnormal_skin_pigmentation	1.93559205
20	MP0000372_irregular_coat_pigmentation	1.92074923
21	MP0005253_abnormal_eye_physiology	1.90975549
22	MP0002736_abnormal_nociception_after	1.90073478
23	MP0005646_abnormal_pituitary_gland	1.85037788
24	MP0006292_abnormal_olfactory_placode	1.81664589
25	MP0004043_abnormal_pH_regulation	1.80830178
26	MP0008875_abnormal_xenobiotic_pharmacok	1.76428881
27	MP0003646_muscle_fatigue	1.75822290
28	MP0005645_abnormal_hypothalamus_physiol	1.73777253
29	MP0010386_abnormal_urinary_bladder	1.72401597
30	MP0008872_abnormal_physiological_respon	1.71614681
31	MP0009745_abnormal_behavioral_response	1.69173208
32	MP0003787_abnormal_imprinting	1.66013586
33	MP0002876_abnormal_thyroid_physiology	1.63107771
34	MP0002638_abnormal_pupillary_reflex	1.62769267
35	MP0003880_abnormal_central_pattern	1.61191207
36	MP0002938_white_spotting	1.60407273
37	MP0001485_abnormal_pinna_reflex	1.60146935
38	MP0003878_abnormal_ear_physiology	1.59075885
39	MP0005377_hearing/vestibular/ear_phenot	1.59075885
40	MP0001986_abnormal_taste_sensitivity	1.55275068
41	MP0002098_abnormal_vibrissa_morphology	1.53366405
42	MP0001188_hyperpigmentation	1.51942049
43	MP0010678_abnormal_skin_adnexa	1.51207328
44	MP0001984_abnormal_olfaction	1.50271248
45	MP0002138_abnormal_hepatobiliary_system	1.48725488
46	MP0004142_abnormal_muscle_tone	1.47802514
47	MP0001501_abnormal_sleep_pattern	1.47061653
48	MP0000631_abnormal_neuroendocrine_gland	1.46428429
49	MP0002272_abnormal_nervous_system	1.45717214
50	MP0004133_heterotaxia	1.36785957
51	MP0002163_abnormal_gland_morphology	1.34538061
52	MP0004147_increased_porphyrin_level	1.31960960
53	MP0005084_abnormal_gallbladder_morpholo	1.22819603
54	MP0002653_abnormal_ependyma_morphology	1.22728123
55	MP0005379_endocrine/exocrine_gland_phen	1.22377874
56	MP0009379_abnormal_foot_pigmentation	1.22206368
57	MP0000015_abnormal_ear_pigmentation	1.21895384
58	MP0001486_abnormal_startle_reflex	1.20352567
59	MP0003252_abnormal_bile_duct	1.15502320
60	MP0002928_abnormal_bile_duct	1.13932033
61	MP0005389_reproductive_system_phenotype	1.13865168
62	MP0006276_abnormal_autonomic_nervous	1.13764832
63	MP0002064_seizures	1.12553882
64	MP0004742_abnormal_vestibular_system	1.09487029
65	MP0002557_abnormal_social/conspecific_i	1.05293056
66	MP0002572_abnormal_emotion/affect_behav	1.05151891
67	MP0001919_abnormal_reproductive_system	1.03429352
68	MP0005386_behavior/neurological_phenoty	0.98847959
69	MP0004924_abnormal_behavior	0.98847959
70	MP0002735_abnormal_chemical_nociception	0.98299644
71	MP0002733_abnormal_thermal_nociception	0.95917470
72	MP0003718_maternal_effect	0.95034176
73	MP0001970_abnormal_pain_threshold	0.94341582
74	MP0001905_abnormal_dopamine_level	0.94166489
75	MP0005195_abnormal_posterior_eye	0.93908565
76	MP0002909_abnormal_adrenal_gland	0.92682382
77	MP0001324_abnormal_eye_pigmentation	0.92378218
78	MP0002160_abnormal_reproductive_system	0.92348680
79	MP0003950_abnormal_plasma_membrane	0.87981971
80	MP0000579_abnormal_nail_morphology	0.87835646
81	MP0002067_abnormal_sensory_capabilities	0.87475708
82	MP0005085_abnormal_gallbladder_physiolo	0.83801432
83	MP0000538_abnormal_urinary_bladder	0.82664923
84	MP0005332_abnormal_amino_acid	0.82434654
85	MP0002277_abnormal_respiratory_mucosa	0.80718031
86	MP0005410_abnormal_fertilization	0.80067110
87	MP0008995_early_reproductive_senescence	0.79593811
88	MP0002234_abnormal_pharynx_morphology	0.79439460
89	MP0000230_abnormal_systemic_arterial	0.78988663
90	MP0001529_abnormal_vocalization	0.78880416
91	MP0005275_abnormal_skin_tensile	0.78617078
92	MP0005647_abnormal_sex_gland	0.77816511
93	MP0000026_abnormal_inner_ear	0.77734480
94	MP0003698_abnormal_male_reproductive	0.76806691
95	MP0001764_abnormal_homeostasis	0.75717317
96	MP0004145_abnormal_muscle_electrophysio	0.75171424
97	MP0002229_neurodegeneration	0.74838153
98	MP0003635_abnormal_synaptic_transmissio	0.74683482
99	MP0000377_abnormal_hair_follicle	0.73830645
100	MP0002752_abnormal_somatic_nervous	0.73810794

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.50264179
2	Congenital stationary night blindness (HP:0007642)	4.10814749
3	Pancreatic fibrosis (HP:0100732)	3.97230917
4	True hermaphroditism (HP:0010459)	3.91458839
5	Abnormality of midbrain morphology (HP:0002418)	3.79180866
6	Molar tooth sign on MRI (HP:0002419)	3.79180866
7	Nephronophthisis (HP:0000090)	3.54851732
8	Hyperventilation (HP:0002883)	3.33901573
9	Abnormality of the renal medulla (HP:0100957)	3.22352746
10	Abnormality of the renal cortex (HP:0011035)	3.16894575
11	Medial flaring of the eyebrow (HP:0010747)	3.13477674
12	Type II lissencephaly (HP:0007260)	3.08653861
13	Attenuation of retinal blood vessels (HP:0007843)	2.96773752
14	Cystic liver disease (HP:0006706)	2.77604005
15	Furrowed tongue (HP:0000221)	2.71038525
16	Pendular nystagmus (HP:0012043)	2.66825338
17	Gaze-evoked nystagmus (HP:0000640)	2.66552562
18	Congenital, generalized hypertrichosis (HP:0004540)	2.64238564
19	Abolished electroretinogram (ERG) (HP:0000550)	2.62188385
20	Tubular atrophy (HP:0000092)	2.60217271
21	Woolly hair (HP:0002224)	2.54638733
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.53902613
23	Polydipsia (HP:0001959)	2.53371378
24	Abnormal drinking behavior (HP:0030082)	2.53371378
25	Erythroderma (HP:0001019)	2.51625240
26	Increased corneal curvature (HP:0100692)	2.50956233
27	Keratoconus (HP:0000563)	2.50956233
28	Gait imbalance (HP:0002141)	2.49848482
29	Chronic hepatic failure (HP:0100626)	2.43666421
30	Congenital primary aphakia (HP:0007707)	2.42772343
31	Progressive cerebellar ataxia (HP:0002073)	2.41192029
32	Hypothermia (HP:0002045)	2.38552365
33	Conjunctival hamartoma (HP:0100780)	2.37067358
34	Brittle hair (HP:0002299)	2.34125891
35	Fair hair (HP:0002286)	2.29604863
36	Decreased central vision (HP:0007663)	2.27929877
37	Febrile seizures (HP:0002373)	2.26853485
38	Nephrogenic diabetes insipidus (HP:0009806)	2.24156973
39	Sclerocornea (HP:0000647)	2.23307441
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.23025501
41	Abnormality of alanine metabolism (HP:0010916)	2.23025501
42	Hyperalaninemia (HP:0003348)	2.23025501
43	Large for gestational age (HP:0001520)	2.21779641
44	Slow-growing hair (HP:0002217)	2.21225933
45	Abnormality of hair growth rate (HP:0011363)	2.21225933
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21082321
47	Decreased circulating renin level (HP:0003351)	2.19969977
48	Renal cortical cysts (HP:0000803)	2.18759772
49	Cerebellar dysplasia (HP:0007033)	2.17686680
50	Genetic anticipation (HP:0003743)	2.14961457
51	Hypotrichosis (HP:0001006)	2.13779625
52	Inability to walk (HP:0002540)	2.13138672
53	Concave nail (HP:0001598)	2.12512525
54	Genital tract atresia (HP:0001827)	2.12399133
55	Hamartoma of the eye (HP:0010568)	2.12178560
56	Polyuria (HP:0000103)	2.08442637
57	Hemiparesis (HP:0001269)	2.06186835
58	Pili torti (HP:0003777)	2.04419689
59	Bony spicule pigmentary retinopathy (HP:0007737)	2.03542419
60	Congenital hepatic fibrosis (HP:0002612)	2.03376784
61	Vaginal atresia (HP:0000148)	2.03206034
62	Lissencephaly (HP:0001339)	2.03175723
63	Broad-based gait (HP:0002136)	1.98555748
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.98028748
65	Anencephaly (HP:0002323)	1.97440292
66	Progressive inability to walk (HP:0002505)	1.95879570
67	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.94819851
68	Absent/shortened dynein arms (HP:0200106)	1.94819851
69	Stomach cancer (HP:0012126)	1.92898900
70	Protruding tongue (HP:0010808)	1.91549550
71	Abnormality of macular pigmentation (HP:0008002)	1.91010999
72	Severe muscular hypotonia (HP:0006829)	1.88229259
73	Abnormality of the axillary hair (HP:0100134)	1.87267964
74	Abnormality of secondary sexual hair (HP:0009888)	1.87267964
75	Male pseudohermaphroditism (HP:0000037)	1.87173582
76	Congenital sensorineural hearing impairment (HP:0008527)	1.86855763
77	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.86016638
78	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.85599937
79	Abnormality of the pons (HP:0007361)	1.83309511
80	Increased CSF lactate (HP:0002490)	1.82366054
81	Aplasia/hypoplasia of the uterus (HP:0008684)	1.81134870
82	Generalized hypopigmentation of hair (HP:0011358)	1.80978857
83	Postaxial foot polydactyly (HP:0001830)	1.80883321
84	Hypoplasia of the pons (HP:0012110)	1.79741549
85	Abnormality of the labia minora (HP:0012880)	1.78787467
86	Chorioretinal atrophy (HP:0000533)	1.78479506
87	Clumsiness (HP:0002312)	1.78083359
88	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.77240710
89	Hypoplasia of the fovea (HP:0007750)	1.77240710
90	Widely spaced teeth (HP:0000687)	1.77175661
91	Bile duct proliferation (HP:0001408)	1.75533200
92	Abnormal biliary tract physiology (HP:0012439)	1.75533200
93	Hypomagnesemia (HP:0002917)	1.73878965
94	Absent speech (HP:0001344)	1.73712583
95	Hyperglycinuria (HP:0003108)	1.73085154
96	Tachypnea (HP:0002789)	1.72285864
97	Dialeptic seizures (HP:0011146)	1.71889291
98	Optic nerve hypoplasia (HP:0000609)	1.71886787
99	Mitochondrial inheritance (HP:0001427)	1.71219178
100	Palmoplantar hyperkeratosis (HP:0000972)	1.70201424

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.21831256
2	BMPR1B	3.49340961
3	ADRBK2	2.93878375
4	WNK3	2.89467512
5	MAP4K2	2.82229089
6	GRK1	2.65537369
7	ACVR1B	2.41055944
8	TAOK3	2.34299919
9	NUAK1	2.33434366
10	WNK4	2.29836283
11	PINK1	2.23605716
12	ZAK	2.14643682
13	CASK	1.94121369
14	OXSR1	1.88618871
15	INSRR	1.86896362
16	MAPK13	1.86740264
17	TLK1	1.85740785
18	STK39	1.70779040
19	TGFBR1	1.60435899
20	MAPKAPK3	1.56162356
21	MAP3K4	1.55369924
22	MKNK2	1.53429873
23	FGFR2	1.25696593
24	DAPK2	1.23862150
25	TNIK	1.22572848
26	NTRK3	1.19762216
27	STK38L	1.18562126
28	TRIM28	1.12290389
29	PAK3	1.10184422
30	MAP2K6	1.08681234
31	MAPKAPK5	1.08560047
32	ADRBK1	1.07063419
33	PRKCE	1.06759326
34	MARK1	0.98682964
35	TXK	0.98253713
36	PLK2	0.98179171
37	PNCK	0.85868123
38	DYRK2	0.85209606
39	BCR	0.84355471
40	PRKCG	0.84105197
41	FER	0.80130255
42	EPHA3	0.79772741
43	PIK3CA	0.78643598
44	STK3	0.76062397
45	IRAK1	0.75344706
46	MKNK1	0.73927748
47	CSNK1G1	0.72360059
48	PHKG2	0.72134598
49	PHKG1	0.72134598
50	CSNK1G2	0.71703685
51	ERBB3	0.69285679
52	TIE1	0.69155921
53	MAP2K7	0.67153868
54	BCKDK	0.66895566
55	PTK2B	0.66574843
56	BRSK2	0.64629064
57	CSNK1G3	0.63002116
58	MST4	0.62396743
59	TRPM7	0.62034285
60	EPHA4	0.59889911
61	PKN1	0.59266358
62	IKBKB	0.59027923
63	VRK1	0.52862553
64	CSNK1A1L	0.52632627
65	AKT3	0.52519745
66	NME1	0.51200168
67	MAP3K7	0.50385446
68	TEC	0.49666395
69	CAMKK2	0.49209988
70	PRKAA2	0.49183461
71	PRKCI	0.48954251
72	PRKCQ	0.48620305
73	NLK	0.47994214
74	CAMK2A	0.47703455
75	KIT	0.47137942
76	WEE1	0.46559754
77	EIF2AK3	0.46510629
78	PRKACA	0.46051723
79	PLK3	0.41817775
80	MUSK	0.40988149
81	LATS1	0.40922451
82	PRKAA1	0.40641449
83	NTRK2	0.39544622
84	RPS6KA5	0.37559377
85	MAPK15	0.37381201
86	CSNK1A1	0.36717748
87	PIK3CG	0.36276355
88	PDK2	0.35486873
89	CAMK1	0.34195297
90	STK11	0.33308762
91	PRKG1	0.33081776
92	PRKCZ	0.33006328
93	SIK2	0.32929948
94	CSNK1D	0.32289378
95	ITK	0.31932178
96	CHUK	0.31189181
97	ERBB2	0.31000672
98	MARK3	0.30768644
99	PRKCA	0.30652961
100	MAP2K4	0.30615107

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.42250353
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.23032791
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.83737327
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.64879508
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.38630212
6	Butanoate metabolism_Homo sapiens_hsa00650	2.36397011
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.25277598
8	Ether lipid metabolism_Homo sapiens_hsa00565	2.21349419
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.17210538
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.14325876
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.96038063
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.95984626
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.87829645
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.83326115
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.81274301
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.80999329
17	Nicotine addiction_Homo sapiens_hsa05033	1.76287125
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.73364320
19	Protein export_Homo sapiens_hsa03060	1.64243276
20	Fatty acid elongation_Homo sapiens_hsa00062	1.62559976
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.52039820
22	Caffeine metabolism_Homo sapiens_hsa00232	1.47604017
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.44353863
24	Retinol metabolism_Homo sapiens_hsa00830	1.40230674
25	Olfactory transduction_Homo sapiens_hsa04740	1.39036998
26	Propanoate metabolism_Homo sapiens_hsa00640	1.38559793
27	Basal transcription factors_Homo sapiens_hsa03022	1.38442300
28	Taste transduction_Homo sapiens_hsa04742	1.37577316
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.36159497
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.32088130
31	Homologous recombination_Homo sapiens_hsa03440	1.31901611
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.27714897
33	RNA polymerase_Homo sapiens_hsa03020	1.26670863
34	ABC transporters_Homo sapiens_hsa02010	1.26160613
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.26043797
36	Parkinsons disease_Homo sapiens_hsa05012	1.24645920
37	Peroxisome_Homo sapiens_hsa04146	1.24397161
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.18400223
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.17929706
40	Morphine addiction_Homo sapiens_hsa05032	1.15025383
41	Histidine metabolism_Homo sapiens_hsa00340	1.12267123
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.09998911
43	Serotonergic synapse_Homo sapiens_hsa04726	1.09126255
44	Glycerolipid metabolism_Homo sapiens_hsa00561	1.08530742
45	beta-Alanine metabolism_Homo sapiens_hsa00410	1.07053068
46	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.03523116
47	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01009623
48	Circadian entrainment_Homo sapiens_hsa04713	0.99986261
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99693403
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.99400983
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.95630813
52	Regulation of autophagy_Homo sapiens_hsa04140	0.95558912
53	RNA degradation_Homo sapiens_hsa03018	0.95281027
54	One carbon pool by folate_Homo sapiens_hsa00670	0.94623877
55	Insulin secretion_Homo sapiens_hsa04911	0.93297796
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.92989458
57	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.89121431
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87623282
59	Salivary secretion_Homo sapiens_hsa04970	0.87131932
60	GABAergic synapse_Homo sapiens_hsa04727	0.86230783
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.86014018
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.84794723
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81916018
64	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.81478844
65	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79221879
66	Huntingtons disease_Homo sapiens_hsa05016	0.78749108
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.78230509
68	Alzheimers disease_Homo sapiens_hsa05010	0.77415578
69	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.76271350
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.75823071
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75604912
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73410550
73	Fatty acid degradation_Homo sapiens_hsa00071	0.72154140
74	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.68421187
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67947572
76	Circadian rhythm_Homo sapiens_hsa04710	0.65168317
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.61787494
78	Metabolic pathways_Homo sapiens_hsa01100	0.59737258
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.59030935
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57942250
81	Mineral absorption_Homo sapiens_hsa04978	0.56794312
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55701346
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.55466626
84	Sulfur metabolism_Homo sapiens_hsa00920	0.53162186
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.51966153
86	Long-term depression_Homo sapiens_hsa04730	0.47485789
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45991893
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43756593
89	Gastric acid secretion_Homo sapiens_hsa04971	0.43642955
90	Purine metabolism_Homo sapiens_hsa00230	0.43376442
91	Renin secretion_Homo sapiens_hsa04924	0.38490297
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37190101
93	Asthma_Homo sapiens_hsa05310	0.36016201
94	Amphetamine addiction_Homo sapiens_hsa05031	0.35758652
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34396993
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33945411
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.31728985
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.31505366
99	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.26625506
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26600208

SEC14L6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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