SEC16A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.60386522
2Golgi transport vesicle coating (GO:0048200)4.60386522
3alpha-linolenic acid metabolic process (GO:0036109)4.26881981
4regulation of cholesterol homeostasis (GO:2000188)4.17274672
5L-phenylalanine catabolic process (GO:0006559)4.11710608
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.11710608
7urea metabolic process (GO:0019627)3.96024461
8urea cycle (GO:0000050)3.96024461
9L-phenylalanine metabolic process (GO:0006558)3.89311889
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.89311889
11negative regulation of fibrinolysis (GO:0051918)3.78919565
12cell-substrate junction assembly (GO:0007044)3.77788244
13cell-substrate adherens junction assembly (GO:0007045)3.77664021
14focal adhesion assembly (GO:0048041)3.77664021
15sulfur amino acid catabolic process (GO:0000098)3.76730476
16adherens junction assembly (GO:0034333)3.75896000
17regulation of histone H3-K27 methylation (GO:0061085)3.73011264
18hemidesmosome assembly (GO:0031581)3.68313936
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.67938582
20positive regulation of fatty acid beta-oxidation (GO:0032000)3.66517877
21peptidyl-glutamic acid carboxylation (GO:0017187)3.64689676
22protein carboxylation (GO:0018214)3.64689676
23lysine catabolic process (GO:0006554)3.63457096
24lysine metabolic process (GO:0006553)3.63457096
25activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.61571631
26cytoskeletal anchoring at plasma membrane (GO:0007016)3.61352011
27mannose metabolic process (GO:0006013)3.60134859
28regulation of fatty acid beta-oxidation (GO:0031998)3.60076147
29complement activation, alternative pathway (GO:0006957)3.59396751
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.57611062
31aromatic amino acid family catabolic process (GO:0009074)3.51696823
32protein localization to endosome (GO:0036010)3.50255541
33intestinal cholesterol absorption (GO:0030299)3.47639672
34epithelial cell differentiation involved in prostate gland development (GO:0060742)3.46485404
35homocysteine metabolic process (GO:0050667)3.45566125
36kynurenine metabolic process (GO:0070189)3.44708470
37nitrogen cycle metabolic process (GO:0071941)3.43119352
38cysteine metabolic process (GO:0006534)3.42331066
39positive regulation of nuclease activity (GO:0032075)3.42006142
40negative regulation of erythrocyte differentiation (GO:0045647)3.39552408
41regulation of protein activation cascade (GO:2000257)3.39068053
42histone H3-K36 demethylation (GO:0070544)3.38884122
43regulation of NFAT protein import into nucleus (GO:0051532)3.36321336
44phospholipid homeostasis (GO:0055091)3.33547861
45negative regulation of sterol transport (GO:0032372)3.32180797
46negative regulation of cholesterol transport (GO:0032375)3.32180797
47macroautophagy (GO:0016236)3.31464920
48negative regulation of cell size (GO:0045792)3.30308208
49valine metabolic process (GO:0006573)3.30037769
50positive regulation of histone deacetylation (GO:0031065)3.28409545
51desmosome organization (GO:0002934)3.27824406
52regulation of fibrinolysis (GO:0051917)3.27038515
53negative regulation of fatty acid transport (GO:2000192)3.25965691
54glucocorticoid receptor signaling pathway (GO:0042921)3.25277757
55* COPII vesicle coating (GO:0048208)3.24250573
56high-density lipoprotein particle remodeling (GO:0034375)3.21081722
57regulation of complement activation (GO:0030449)3.20745934
58regulation of glucose import in response to insulin stimulus (GO:2001273)3.19975256
59semaphorin-plexin signaling pathway (GO:0071526)3.18314277
604-hydroxyproline metabolic process (GO:0019471)3.16453172
61activation of Rac GTPase activity (GO:0032863)3.13763033
62reverse cholesterol transport (GO:0043691)3.13634090
632-oxoglutarate metabolic process (GO:0006103)3.13088479
64positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.12932414
65L-alpha-amino acid transmembrane transport (GO:1902475)3.11959925
66endoplasmic reticulum unfolded protein response (GO:0030968)3.10348434
67maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09725342
68regulation of nuclease activity (GO:0032069)3.08168975
69tryptophan metabolic process (GO:0006568)3.05260562
70tryptophan catabolic process (GO:0006569)3.04482542
71indole-containing compound catabolic process (GO:0042436)3.04482542
72indolalkylamine catabolic process (GO:0046218)3.04482542
73bile acid biosynthetic process (GO:0006699)3.02723109
74basement membrane organization (GO:0071711)3.02397558
75positive regulation of glycolytic process (GO:0045821)3.01986607
76response to laminar fluid shear stress (GO:0034616)3.01554890
77intracellular estrogen receptor signaling pathway (GO:0030520)3.01228041
78glyoxylate metabolic process (GO:0046487)3.00661600
79dicarboxylic acid biosynthetic process (GO:0043650)2.98834457
80cellular modified amino acid catabolic process (GO:0042219)2.97507965
81cellular response to unfolded protein (GO:0034620)2.97346833
82serine family amino acid catabolic process (GO:0009071)2.97178159
83embryonic retina morphogenesis in camera-type eye (GO:0060059)2.96518028
84embryonic process involved in female pregnancy (GO:0060136)2.94981451
85acylglycerol homeostasis (GO:0055090)2.94942362
86triglyceride homeostasis (GO:0070328)2.94942362
87ER-nucleus signaling pathway (GO:0006984)2.94026382
88phospholipid efflux (GO:0033700)2.92493262
89insulin-like growth factor receptor signaling pathway (GO:0048009)2.92154479
90plasma lipoprotein particle clearance (GO:0034381)2.91472759
91retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.90376932
92apoptotic process involved in morphogenesis (GO:0060561)2.89866617
93low-density lipoprotein particle clearance (GO:0034383)2.89308710
94maternal placenta development (GO:0001893)2.89148704
95regulation of triglyceride catabolic process (GO:0010896)2.88872635
96negative regulation of lipid transport (GO:0032369)2.87855032
97positive regulation of blood vessel endothelial cell migration (GO:0043536)2.87685630
98hormone catabolic process (GO:0042447)2.87459591
99regulation of RNA export from nucleus (GO:0046831)2.87127900
100bile acid metabolic process (GO:0008206)2.86923784
101endothelial cell chemotaxis (GO:0035767)2.86597567
102lipoprotein metabolic process (GO:0042157)2.86018210
103planar cell polarity pathway involved in neural tube closure (GO:0090179)2.85182858
104cytoplasmic mRNA processing body assembly (GO:0033962)2.84611367
105positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.83365381
106exocrine pancreas development (GO:0031017)2.83109689
107corticosteroid receptor signaling pathway (GO:0031958)2.81624294
108intestinal absorption (GO:0050892)2.79993433
109regulation of nucleobase-containing compound transport (GO:0032239)2.79693302
110regulation of early endosome to late endosome transport (GO:2000641)2.79688632
111growth hormone receptor signaling pathway (GO:0060396)2.79563405
112positive regulation of lipid catabolic process (GO:0050996)2.77481221
113plasma lipoprotein particle assembly (GO:0034377)2.76767466
114positive regulation of keratinocyte differentiation (GO:0045618)2.76760109
115protein-lipid complex assembly (GO:0065005)2.76153205
116epithelial cell-cell adhesion (GO:0090136)2.75703936
117tricarboxylic acid metabolic process (GO:0072350)2.74759694
118tyrosine metabolic process (GO:0006570)2.74440241
119bile acid and bile salt transport (GO:0015721)2.73859527
120fatty acid transmembrane transport (GO:1902001)2.73696032
121regulation of ARF protein signal transduction (GO:0032012)2.72578741
122positive regulation of fatty acid oxidation (GO:0046321)2.72116453
123positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.71911099
124apoptotic cell clearance (GO:0043277)2.71211340
125cellular response to topologically incorrect protein (GO:0035967)2.70978756
126regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70670321
127regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.68934994
128regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.68365144
129amino-acid betaine metabolic process (GO:0006577)2.67237448
130branching involved in mammary gland duct morphogenesis (GO:0060444)2.67115229
131protein retention in ER lumen (GO:0006621)2.67004455
132positive regulation of glycogen biosynthetic process (GO:0045725)2.66529467
133atrioventricular valve morphogenesis (GO:0003181)2.65361902
134skin morphogenesis (GO:0043589)2.64015574
135embryonic eye morphogenesis (GO:0048048)2.62614539
136positive regulation of Cdc42 GTPase activity (GO:0043089)2.62181560
137plasma lipoprotein particle remodeling (GO:0034369)2.61508676
138protein-lipid complex remodeling (GO:0034368)2.61508676
139macromolecular complex remodeling (GO:0034367)2.61508676
140fatty acid homeostasis (GO:0055089)2.61060227
141cholesterol efflux (GO:0033344)2.60404104
142carnitine shuttle (GO:0006853)2.58425520
143regulation of extracellular matrix disassembly (GO:0010715)2.58313706
144embryonic camera-type eye morphogenesis (GO:0048596)2.57435844
145regulation of water loss via skin (GO:0033561)2.57280203
146stress fiber assembly (GO:0043149)2.56819387
147histone lysine demethylation (GO:0070076)2.56601595
148dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.55045418
149cholesterol homeostasis (GO:0042632)2.53971025
150alpha-amino acid catabolic process (GO:1901606)2.53742345
151sterol homeostasis (GO:0055092)2.53737472
152regulation of endothelial cell chemotaxis (GO:2001026)2.52291828
153regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.49794892
154hypotonic response (GO:0006971)2.45267152
155histone demethylation (GO:0016577)2.44781112
156cellular response to epidermal growth factor stimulus (GO:0071364)2.43567188
157regulation of mammary gland epithelial cell proliferation (GO:0033599)2.43195524
158modulation by virus of host morphology or physiology (GO:0019048)2.41828929
1593-UTR-mediated mRNA stabilization (GO:0070935)2.40358291
160negative regulation of viral release from host cell (GO:1902187)2.38200357
161peptidyl-lysine dimethylation (GO:0018027)2.38180326
162peptidyl-tyrosine autophosphorylation (GO:0038083)2.35900598
163iron ion import (GO:0097286)2.34378031
164ear development (GO:0043583)2.33827046
165positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.33448492
166spliceosomal tri-snRNP complex assembly (GO:0000244)2.33016994
167surfactant homeostasis (GO:0043129)2.32847961
168histone H3-K9 demethylation (GO:0033169)2.32650339
169cell-cell junction maintenance (GO:0045217)2.32401036
170positive regulation of extracellular matrix organization (GO:1903055)2.30650007
171vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.30476431
172cell adhesion mediated by integrin (GO:0033627)2.29883128
173nuclear pore complex assembly (GO:0051292)2.29704390
174trophectodermal cell differentiation (GO:0001829)2.28132352
175regulation of integrin activation (GO:0033623)2.26159239
176histone H3-K4 methylation (GO:0051568)2.25770206
177response to epidermal growth factor (GO:0070849)2.22736106
178regulation of extracellular matrix organization (GO:1903053)2.22433494
179* vesicle coating (GO:0006901)2.21207999
180mitotic chromosome condensation (GO:0007076)2.21062772
181eye morphogenesis (GO:0048592)2.20286818
182negative regulation of myotube differentiation (GO:0010832)2.19892990
183glucose 6-phosphate metabolic process (GO:0051156)2.18678897
184modulation by symbiont of host cellular process (GO:0044068)2.17288119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.24086510
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.79215294
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.40465448
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.13754886
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40109625
6NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.18636022
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.78647015
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.77461540
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.57050071
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.52023534
11CLOCK_20551151_ChIP-Seq_293T_Human2.51887146
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.45819115
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35422262
14MYC_22102868_ChIP-Seq_BL_Human2.12168084
15GATA1_22025678_ChIP-Seq_K562_Human2.10174914
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08859766
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99176628
18FOXA2_19822575_ChIP-Seq_HepG2_Human1.92932035
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.85268250
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84218473
21* TCF7_22412390_ChIP-Seq_EML_Mouse1.72222889
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71312529
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.63432868
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63127182
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.62963341
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61677272
27VDR_24763502_ChIP-Seq_THP-1_Human1.60853229
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56140805
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55932214
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52231932
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.50458399
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.48291560
33KDM2B_26808549_Chip-Seq_DND41_Human1.46693438
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46159007
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45338051
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43437658
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42201772
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41951644
39DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41516936
40GATA6_25053715_ChIP-Seq_YYC3_Human1.39071049
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38805165
42E2F7_22180533_ChIP-Seq_HELA_Human1.37529536
43* SMC4_20622854_ChIP-Seq_HELA_Human1.36651048
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35453036
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.35423723
46* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34370990
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33549986
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32581491
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32562132
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.31150450
51ZNF263_19887448_ChIP-Seq_K562_Human1.31073891
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30890642
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30837543
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30473153
55FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.28485601
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27714889
57TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26106814
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25077677
59* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24942119
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24073013
61TBX20_22080862_ChIP-Seq_HEART_Mouse1.23221428
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.23221428
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22746196
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21789035
65HNF4A_19822575_ChIP-Seq_HepG2_Human1.21625338
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.20841686
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20670899
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19487211
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.19442675
70* P68_20966046_ChIP-Seq_HELA_Human1.17634295
71UBF1/2_26484160_Chip-Seq_HMECs_Human1.17426772
72ATF3_27146783_Chip-Seq_COLON_Human1.17188843
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16810799
74RACK7_27058665_Chip-Seq_MCF-7_Human1.16029514
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.14340415
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.14200420
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.14055652
78TP53_22127205_ChIP-Seq_IMR90_Human1.13781188
79MAF_26560356_Chip-Seq_TH2_Human1.13558718
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12667633
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11849586
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11849291
83LXR_22292898_ChIP-Seq_THP-1_Human1.11785035
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11667835
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11570348
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11088368
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.10785959
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.10623352
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10482382
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10110957
91CREB1_26743006_Chip-Seq_LNCaP_Human1.08078969
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07636282
93GATA1_19941826_ChIP-Seq_K562_Human1.07130704
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07054723
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07054723
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06140840
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05198593
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05171892
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.04759682
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04238585
101UTX_26944678_Chip-Seq_JUKART_Human1.04074636
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03810819
103MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03657635
104KDM2B_26808549_Chip-Seq_K562_Human1.03403871
105GATA4_25053715_ChIP-Seq_YYC3_Human1.03384978
106* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03114204
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02429429
108TET1_21451524_ChIP-Seq_MESCs_Mouse1.02387807
109NCOR1_26117541_ChIP-Seq_K562_Human1.02098080
110PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01999223
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01749123
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01427006
113SALL1_21062744_ChIP-ChIP_HESCs_Human0.99800232
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99526131
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98737910
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98577614
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98388349
118VDR_21846776_ChIP-Seq_THP-1_Human0.98350329
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97099361
120SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97084382
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95893131
122NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95830205
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95193992
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94093274
125MAF_26560356_Chip-Seq_TH1_Human0.92456407
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91908053
127CHD1_26751641_Chip-Seq_LNCaP_Human0.91750537
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91217800
129FOXM1_23109430_ChIP-Seq_U2OS_Human0.91013054
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89413194
131* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87705720
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.87023312
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86100623
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85929076
135ISL1_27105846_Chip-Seq_CPCs_Mouse0.85527535
136* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85515205
137MYB_26560356_Chip-Seq_TH1_Human0.85498566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.94830030
2MP0005360_urolithiasis4.37724951
3MP0005365_abnormal_bile_salt4.35636026
4MP0003705_abnormal_hypodermis_morpholog3.63283640
5MP0005085_abnormal_gallbladder_physiolo3.56861264
6MP0003252_abnormal_bile_duct3.55477997
7MP0005451_abnormal_body_composition2.85375390
8MP0005409_darkened_coat_color2.67724724
9MP0003300_gastrointestinal_ulcer2.54494455
10MP0010329_abnormal_lipoprotein_level2.40622574
11MP0008875_abnormal_xenobiotic_pharmacok2.38266742
12MP0001666_abnormal_nutrient_absorption2.28402754
13MP0010234_abnormal_vibrissa_follicle2.22765052
14MP0004858_abnormal_nervous_system2.14249390
15MP0009840_abnormal_foam_cell2.11878876
16MP0004233_abnormal_muscle_weight2.10724004
17MP0004264_abnormal_extraembryonic_tissu2.06528304
18MP0002796_impaired_skin_barrier2.03008460
19MP0005076_abnormal_cell_differentiation2.02957029
20MP0010352_gastrointestinal_tract_polyps1.97960129
21MP0002877_abnormal_melanocyte_morpholog1.97415866
22MP0005083_abnormal_biliary_tract1.89559265
23MP0002009_preneoplasia1.88674397
24MP0000609_abnormal_liver_physiology1.80933473
25MP0003868_abnormal_feces_composition1.69373066
26MP0005220_abnormal_exocrine_pancreas1.68019243
27MP0001348_abnormal_lacrimal_gland1.65351055
28MP0005670_abnormal_white_adipose1.59285606
29MP0008260_abnormal_autophagy1.58185332
30MP0008438_abnormal_cutaneous_collagen1.56700037
31MP0009780_abnormal_chondrocyte_physiolo1.55126089
32MP0008961_abnormal_basal_metabolism1.54044761
33MP0000569_abnormal_digit_pigmentation1.53294476
34MP0002138_abnormal_hepatobiliary_system1.48018208
35MP0001873_stomach_inflammation1.45903656
36MP0004381_abnormal_hair_follicle1.45151453
37MP0002396_abnormal_hematopoietic_system1.41332971
38MP0002118_abnormal_lipid_homeostasis1.40436247
39MP0003566_abnormal_cell_adhesion1.39102714
40MP0002928_abnormal_bile_duct1.36602207
41MP0004808_abnormal_hematopoietic_stem1.36412037
42MP0009278_abnormal_bone_marrow1.35623754
43MP0003195_calcinosis1.35252771
44MP0003191_abnormal_cellular_cholesterol1.34534329
45MP0004272_abnormal_basement_membrane1.34073599
46MP0004185_abnormal_adipocyte_glucose1.33426544
47MP0003806_abnormal_nucleotide_metabolis1.30589570
48MP0005501_abnormal_skin_physiology1.30091930
49MP0005332_abnormal_amino_acid1.30036872
50MP0003763_abnormal_thymus_physiology1.29740577
51MP0000579_abnormal_nail_morphology1.29628568
52MP0001216_abnormal_epidermal_layer1.28259930
53MP0005666_abnormal_adipose_tissue1.27451410
54MP0003045_fibrosis1.27365264
55MP0000858_altered_metastatic_potential1.25823404
56MP0001944_abnormal_pancreas_morphology1.25549669
57MP0004782_abnormal_surfactant_physiolog1.24938786
58MP0002098_abnormal_vibrissa_morphology1.24881129
59MP0005623_abnormal_meninges_morphology1.24205207
60MP0002089_abnormal_postnatal_growth/wei1.23545577
61MP0001958_emphysema1.21196049
62MP0003283_abnormal_digestive_organ1.18962981
63MP0003436_decreased_susceptibility_to1.18171684
64MP0002166_altered_tumor_susceptibility1.17770659
65MP0005621_abnormal_cell_physiology1.15554078
66MP0009643_abnormal_urine_homeostasis1.15156843
67MP0000678_abnormal_parathyroid_gland1.14321607
68MP0010368_abnormal_lymphatic_system1.13370246
69MP0000003_abnormal_adipose_tissue1.12303263
70MP0005375_adipose_tissue_phenotype1.12135460
71MP0002254_reproductive_system_inflammat1.12113985
72MP0004130_abnormal_muscle_cell1.12105950
73MP0002249_abnormal_larynx_morphology1.11664448
74MP0005319_abnormal_enzyme/_coenzyme1.11269691
75MP0005023_abnormal_wound_healing1.11233548
76MP0002909_abnormal_adrenal_gland1.10714648
77MP0000598_abnormal_liver_morphology1.08826322
78MP0002078_abnormal_glucose_homeostasis1.08506369
79MP0005275_abnormal_skin_tensile1.07473496
80MP0009672_abnormal_birth_weight1.07218745
81MP0005248_abnormal_Harderian_gland1.04587189
82MP0000467_abnormal_esophagus_morphology1.03259639
83MP0006054_spinal_hemorrhage1.02527073
84MP0002693_abnormal_pancreas_physiology1.02462826
85MP0009931_abnormal_skin_appearance1.01817081
86MP0002896_abnormal_bone_mineralization1.01557203
87MP0001730_embryonic_growth_arrest1.00839258
88MP0002168_other_aberrant_phenotype1.00381273
89MP0002006_tumorigenesis0.99876717
90MP0000377_abnormal_hair_follicle0.99594647
91MP0005310_abnormal_salivary_gland0.99084366
92MP0009053_abnormal_anal_canal0.95048130
93MP0000627_abnormal_mammary_gland0.94839323
94MP0009384_cardiac_valve_regurgitation0.93031492
95MP0010307_abnormal_tumor_latency0.91912489
96MP0004019_abnormal_vitamin_homeostasis0.91263568
97MP0001849_ear_inflammation0.87797222
98MP0002060_abnormal_skin_morphology0.87155253
99MP0003172_abnormal_lysosome_physiology0.81887191
100MP0010678_abnormal_skin_adnexa0.80313925
101MP0005334_abnormal_fat_pad0.80274499
102MP0002998_abnormal_bone_remodeling0.79698577
103MP0000566_synostosis0.79297566
104MP0001915_intracranial_hemorrhage0.78984901
105MP0001756_abnormal_urination0.78313141
106MP0009703_decreased_birth_body0.77958189
107MP0004947_skin_inflammation0.76189380
108MP0003091_abnormal_cell_migration0.75346808
109MP0005187_abnormal_penis_morphology0.75325619
110MP0006138_congestive_heart_failure0.73690435
111MP0004197_abnormal_fetal_growth/weight/0.73643036
112MP0003115_abnormal_respiratory_system0.72375267
113MP0002925_abnormal_cardiovascular_devel0.72319992
114MP0010155_abnormal_intestine_physiology0.71862330
115MP0001672_abnormal_embryogenesis/_devel0.71333846
116MP0005380_embryogenesis_phenotype0.71333846
117MP0002086_abnormal_extraembryonic_tissu0.70791266
118MP0003303_peritoneal_inflammation0.70332518
119MP0000350_abnormal_cell_proliferation0.70206063
120MP0001661_extended_life_span0.69966655
121MP0002080_prenatal_lethality0.69676006
122MP0003183_abnormal_peptide_metabolism0.68313352
123MP0003329_amyloid_beta_deposits0.68026270
124MP0002971_abnormal_brown_adipose0.67114767
125MP0002088_abnormal_embryonic_growth/wei0.66608453
126MP0003279_aneurysm0.66603311
127MP0000462_abnormal_digestive_system0.66571947
128MP0005384_cellular_phenotype0.66070838
129MP0000733_abnormal_muscle_development0.65982919
130MP0001851_eye_inflammation0.65594389
131MP0010771_integument_phenotype0.65264731
132MP0002108_abnormal_muscle_morphology0.64973267
133MP0000371_diluted_coat_color0.64887043
134MP0010630_abnormal_cardiac_muscle0.64597538
135MP0005448_abnormal_energy_balance0.64284094
136MP0003984_embryonic_growth_retardation0.64049233
137MP0000477_abnormal_intestine_morphology0.63696225
138MP0002269_muscular_atrophy0.63305123
139MP0000534_abnormal_ureter_morphology0.62602526
140MP0000767_abnormal_smooth_muscle0.62552109
141MP0000013_abnormal_adipose_tissue0.61664842
142MP0002970_abnormal_white_adipose0.61288263
143MP0009115_abnormal_fat_cell0.61091481
144MP0003453_abnormal_keratinocyte_physiol0.60578560
145MP0002837_dystrophic_cardiac_calcinosis0.60189047
146MP0003890_abnormal_embryonic-extraembry0.58620842
147MP0005058_abnormal_lysosome_morphology0.58538998
148MP0005257_abnormal_intraocular_pressure0.58396623
149MP0009763_increased_sensitivity_to0.57946512
150MP0000537_abnormal_urethra_morphology0.57563081
151MP0005647_abnormal_sex_gland0.57022340
152MP0001243_abnormal_dermal_layer0.55459836
153MP0009642_abnormal_blood_homeostasis0.55336101

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.39676068
2Intrahepatic cholestasis (HP:0001406)4.15704565
3Broad face (HP:0000283)3.88218658
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.81712341
5Hypoglycemic coma (HP:0001325)3.59721082
6Xanthomatosis (HP:0000991)3.57939300
7Abnormality of the common coagulation pathway (HP:0010990)3.36671314
8Complement deficiency (HP:0004431)3.36012747
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.26823380
10Flat acetabular roof (HP:0003180)3.18225586
11Hypoglycemic seizures (HP:0002173)3.16659815
12Abnormality of the intrinsic pathway (HP:0010989)3.10065807
13Hyperinsulinemic hypoglycemia (HP:0000825)3.03439448
14Obstructive sleep apnea (HP:0002870)2.97052207
15Myocardial infarction (HP:0001658)2.93761983
16Cerebral aneurysm (HP:0004944)2.92766786
17Epidermoid cyst (HP:0200040)2.91063697
18Hypobetalipoproteinemia (HP:0003563)2.87163555
19Hyperglycemia (HP:0003074)2.85598039
20Ketosis (HP:0001946)2.81962314
21Premature rupture of membranes (HP:0001788)2.73509276
22Sparse lateral eyebrow (HP:0005338)2.68726232
23Ketoacidosis (HP:0001993)2.68361852
24Hypoalphalipoproteinemia (HP:0003233)2.67576132
25Abnormality of the fingertips (HP:0001211)2.66410804
26Aneurysm (HP:0002617)2.65392184
27Abnormality of sulfur amino acid metabolism (HP:0004339)2.63217743
28Abnormality of the distal phalanx of the thumb (HP:0009617)2.60451306
29Hypolipoproteinemia (HP:0010981)2.59286205
30Skin nodule (HP:0200036)2.58559442
31Abnormality of endocrine pancreas physiology (HP:0012093)2.56223189
32Abnormality of the pancreatic islet cells (HP:0006476)2.56223189
33Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51573987
34Abnormality of complement system (HP:0005339)2.49563965
35Conjugated hyperbilirubinemia (HP:0002908)2.43080089
36Prolonged partial thromboplastin time (HP:0003645)2.43052798
37Macroorchidism (HP:0000053)2.41277838
38Esophageal varix (HP:0002040)2.38147064
39Asymmetry of the thorax (HP:0001555)2.36914444
40Aortic aneurysm (HP:0004942)2.35872058
41Atrophic scars (HP:0001075)2.35764117
42Hyperlipoproteinemia (HP:0010980)2.35745097
43Advanced eruption of teeth (HP:0006288)2.34632873
44Fat malabsorption (HP:0002630)2.31159744
45Long eyelashes (HP:0000527)2.28586081
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26836153
47Mitral valve prolapse (HP:0001634)2.26090193
48Long palpebral fissure (HP:0000637)2.25888899
49Protrusio acetabuli (HP:0003179)2.24547776
50Distal lower limb amyotrophy (HP:0008944)2.22274705
51Mitral stenosis (HP:0001718)2.22200638
52Pancreatic islet-cell hyperplasia (HP:0004510)2.21586602
53Fragile skin (HP:0001030)2.19469230
54Hepatocellular carcinoma (HP:0001402)2.17636519
55Short nail (HP:0001799)2.17381271
56Ankyloglossia (HP:0010296)2.16764165
57Long toe (HP:0010511)2.16541724
58Symptomatic seizures (HP:0011145)2.15873913
59Hyperammonemia (HP:0001987)2.13539928
60Lymphangioma (HP:0100764)2.12952070
61Hand muscle atrophy (HP:0009130)2.12270015
62Hypercholesterolemia (HP:0003124)2.09831446
63Late onset (HP:0003584)2.07486163
64Increased connective tissue (HP:0009025)2.06772608
65Dislocated radial head (HP:0003083)2.06748036
66Arterial tortuosity (HP:0005116)2.05880940
67Osteolytic defects of the hand bones (HP:0009699)2.05475973
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.05475973
69Natal tooth (HP:0000695)2.04639250
70Abnormality of the distal phalanges of the toes (HP:0010182)2.04105453
71Dysmetric saccades (HP:0000641)2.03923253
72Insulin-resistant diabetes mellitus (HP:0000831)2.01350589
73Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.99462488
74Turricephaly (HP:0000262)1.98592712
75Spastic diplegia (HP:0001264)1.97827246
76Abnormality of purine metabolism (HP:0004352)1.97573900
77Blue sclerae (HP:0000592)1.97302732
78Abnormality of oral frenula (HP:0000190)1.97104741
79Germ cell neoplasia (HP:0100728)1.96658749
80Abnormal ossification of hand bones (HP:0005921)1.96443536
81Vertebral compression fractures (HP:0002953)1.94161081
82Spinal cord lesions (HP:0100561)1.93604793
83Syringomyelia (HP:0003396)1.93604793
84Pseudobulbar signs (HP:0002200)1.92770266
85Abnormality of the radial head (HP:0003995)1.92757150
86Achilles tendon contracture (HP:0001771)1.92481328
87Hyperglycinuria (HP:0003108)1.92026798
88Back pain (HP:0003418)1.92016061
89Joint hemorrhage (HP:0005261)1.91798599
90Vascular tortuosity (HP:0004948)1.91540296
91Subacute progressive viral hepatitis (HP:0006572)1.90951432
92Upper limb amyotrophy (HP:0009129)1.90946365
93Distal upper limb amyotrophy (HP:0007149)1.90946365
94Patellar dislocation (HP:0002999)1.90682434
95Shallow orbits (HP:0000586)1.88965674
96Milia (HP:0001056)1.88614539
97Persistence of primary teeth (HP:0006335)1.85848484
98Abnormality of the Achilles tendon (HP:0005109)1.83851507
99Insulin resistance (HP:0000855)1.83495856
100Abnormality of carpal bone ossification (HP:0006257)1.83111225
101Urinary glycosaminoglycan excretion (HP:0003541)1.81816437
102Mucopolysacchariduria (HP:0008155)1.81816437
103Hemorrhage of the eye (HP:0011885)1.81256117
104Wormian bones (HP:0002645)1.80551958
105Genu recurvatum (HP:0002816)1.78453198
106Lip pit (HP:0100267)1.78135368
107Abnormality of the thoracic spine (HP:0100711)1.77970460
108Hypoplastic ischia (HP:0003175)1.77577635
109Absent frontal sinuses (HP:0002688)1.77549603
110Joint laxity (HP:0001388)1.77317889
111Gout (HP:0001997)1.76686034
112Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76320457
113Heterotopia (HP:0002282)1.75091169
114Abnormality of the ischium (HP:0003174)1.74896771
115Abnormality of nucleobase metabolism (HP:0010932)1.74739184
116Right ventricular cardiomyopathy (HP:0011663)1.74238320
117Abnormality of the phalanges of the hallux (HP:0010057)1.74052382
118Hyperglycinemia (HP:0002154)1.73267001
119Mitral regurgitation (HP:0001653)1.72203550
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72023697
121Abnormality of polysaccharide metabolism (HP:0011012)1.72023697
122Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72023697
123Abnormality of glycine metabolism (HP:0010895)1.71420914
124Abnormality of serine family amino acid metabolism (HP:0010894)1.71420914
125Centrally nucleated skeletal muscle fibers (HP:0003687)1.70348127
126Biconcave vertebral bodies (HP:0004586)1.70048206
127Enlarged penis (HP:0000040)1.69999643
128J-shaped sella turcica (HP:0002680)1.69536177
129Interstitial pulmonary disease (HP:0006530)1.68707071
130Septate vagina (HP:0001153)1.67678536
131Precocious puberty (HP:0000826)1.67409135
132Distal lower limb muscle weakness (HP:0009053)1.67291448
133Abnormality of proline metabolism (HP:0010907)1.66296160
134Hydroxyprolinuria (HP:0003080)1.66296160
135Ulnar bowing (HP:0003031)1.65986063
136Bladder diverticulum (HP:0000015)1.65167064
137Ectopia lentis (HP:0001083)1.64377139
138Protuberant abdomen (HP:0001538)1.64162605
139Hematochezia (HP:0002573)1.63268465
140Cervical subluxation (HP:0003308)1.62883251
141Thin bony cortex (HP:0002753)1.62294946
142Narrow palate (HP:0000189)1.62164139
143Urethral obstruction (HP:0000796)1.61536600
144Hyperacusis (HP:0010780)1.61167967
145Dilatation of the ascending aorta (HP:0005111)1.60397897
146Severe short stature (HP:0003510)1.60215532
147Mildly elevated creatine phosphokinase (HP:0008180)1.60056280
148Hyperparathyroidism (HP:0000843)1.60016415
149Bronchomalacia (HP:0002780)1.59344491
150Disproportionate tall stature (HP:0001519)1.59278620
151Peritonitis (HP:0002586)1.59153171
152Spinal rigidity (HP:0003306)1.59090859
153Abdominal distention (HP:0003270)1.57565003
154Overgrowth (HP:0001548)1.56518710
155Abnormality of nail color (HP:0100643)1.56513218
156Abnormality of aspartate family amino acid metabolism (HP:0010899)1.56408236
157Renovascular hypertension (HP:0100817)1.55662671
158Cortical dysplasia (HP:0002539)1.55464133
159Abnormality of the 4th metacarpal (HP:0010012)1.55363410
160Ankle contracture (HP:0006466)1.54889472
161Striae distensae (HP:0001065)1.54835591
162Neonatal death (HP:0003811)1.54729324
163Aortic dissection (HP:0002647)1.54219378
164Insomnia (HP:0100785)1.53969265
165Vertebral arch anomaly (HP:0008438)1.53006379
166Self-mutilation (HP:0000742)1.52816556
167Cerebral inclusion bodies (HP:0100314)1.52102849
168Increased variability in muscle fiber diameter (HP:0003557)1.51509532
169Abnormal foot bone ossification (HP:0010675)1.51444252
170Deformed sella turcica (HP:0002681)1.51007194
171Atelectasis (HP:0100750)1.48745510
172Segmental peripheral demyelination/remyelination (HP:0003481)1.48613407
173Ureteral stenosis (HP:0000071)1.48350716
174Arnold-Chiari malformation (HP:0002308)1.46805745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.66063061
2LATS13.59581863
3SMG13.40615366
4TRIB33.34099861
5SIK13.03001447
6TAOK32.90690147
7PKN22.88886230
8CDK122.88715371
9PRPF4B2.77736798
10EEF2K2.30937774
11CAMK1D2.29579591
12INSRR2.23081070
13MAP3K102.21748241
14RIPK12.17427602
15FGFR42.16574243
16PTK62.10915267
17FRK2.01947100
18CAMK1G1.95189343
19IRAK31.88661967
20PDGFRA1.79964353
21FLT31.67472347
22TTN1.65605678
23MTOR1.51326360
24JAK11.37160174
25BCKDK1.34127963
26SCYL21.30089968
27FGFR31.29483843
28MAP3K131.26461052
29STK31.19192045
30ICK1.18789217
31KSR21.15642878
32PTK21.14169379
33MAP3K71.10169954
34EPHA31.07402766
35BRD41.07184064
36EPHB11.05030739
37PASK1.03093748
38TYK21.00756096
39RPS6KA21.00280603
40PDGFRB0.98234966
41MAP3K20.96472370
42CDK60.96178562
43MAP4K10.94526178
44RIPK40.93726795
45JAK30.93693183
46SGK30.93392447
47STK100.90106308
48JAK20.89348855
49FGFR20.87003293
50TAOK10.86691983
51HIPK20.84768724
52TGFBR20.84399779
53PRKD30.83630214
54PRKAA10.83357472
55SIK20.83104271
56PRKCH0.79586617
57DYRK1B0.79003042
58RET0.77597383
59PAK20.77319888
60LRRK20.75319337
61TAOK20.74500652
62TRPM70.74409868
63NUAK10.72803651
64PDPK10.72535595
65PRKAA20.72479071
66CHUK0.71991147
67DDR20.71235155
68MAP3K140.70571151
69MET0.68721439
70CDK70.67684774
71ITK0.66915750
72EPHA20.66396440
73MAP3K30.65479259
74CDK90.65268178
75LATS20.64410703
76ERBB40.64225726
77RPS6KC10.64101063
78RPS6KL10.64101063
79FGFR10.63916479
80STK38L0.63814166
81TNK20.61946666
82BMX0.61406852
83DMPK0.59259882
84SIK30.59209467
85MAP3K60.58661223
86ZAP700.58109189
87PIK3CG0.58072961
88CDC42BPA0.57947004
89CDK40.56805977
90IRAK20.54384031
91TESK10.54311808
92ARAF0.53565465
93AKT30.53091235
94NTRK10.52796633
95ERBB20.52709044
96STK380.52363405
97RPS6KB20.52304848
98NEK90.51885399
99MAP2K20.51377565
100MAPK110.50976500
101NEK60.50306799
102CAMKK10.49889290
103NEK20.49392401
104MAP2K30.48890595
105MAP3K10.48532549
106CSF1R0.48531048
107MELK0.48410307
108CSK0.48316464
109MAP3K90.47385683
110GSK3A0.46005873
111WNK10.43799349
112SGK20.43128987
113ALK0.42728621
114RPS6KA40.42447880
115FER0.42025510
116PIM20.41907541
117PDK10.41543408
118RPS6KA60.41537566
119MST1R0.41246939
120MARK20.40489174
121PAK30.40362362
122PRKD10.39603934
123TYRO30.37913134
124TBK10.37766954
125MAP3K80.36369093
126EGFR0.35806730
127MAPK100.34738658
128GRK60.34578506
129LMTK20.34230040
130PAK40.33766944
131IRAK40.33649346
132MAPK10.33239738
133PRKD20.32378279
134IGF1R0.31619978
135MAPKAPK30.30282994

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.51144996
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.96901314
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.82571732
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.74944118
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54388019
6Arginine biosynthesis_Homo sapiens_hsa002202.44716753
7Tryptophan metabolism_Homo sapiens_hsa003802.20160950
8Lysine degradation_Homo sapiens_hsa003102.11269013
9Complement and coagulation cascades_Homo sapiens_hsa046102.04332974
10Fatty acid degradation_Homo sapiens_hsa000712.03340720
11Selenocompound metabolism_Homo sapiens_hsa004501.99251501
12Other glycan degradation_Homo sapiens_hsa005111.88375809
13Thyroid cancer_Homo sapiens_hsa052161.71648061
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69382948
15PPAR signaling pathway_Homo sapiens_hsa033201.66461165
16Caffeine metabolism_Homo sapiens_hsa002321.63834837
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62671182
18VEGF signaling pathway_Homo sapiens_hsa043701.61440374
19Fat digestion and absorption_Homo sapiens_hsa049751.59810516
20Renal cell carcinoma_Homo sapiens_hsa052111.57865839
21ABC transporters_Homo sapiens_hsa020101.50711258
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47109672
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46916757
24Fatty acid metabolism_Homo sapiens_hsa012121.44983723
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42449084
26Insulin resistance_Homo sapiens_hsa049311.42226692
27Bile secretion_Homo sapiens_hsa049761.41140400
28ErbB signaling pathway_Homo sapiens_hsa040121.40846992
29B cell receptor signaling pathway_Homo sapiens_hsa046621.40374683
30Glioma_Homo sapiens_hsa052141.37695119
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37175926
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34507370
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33548641
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32612462
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31985997
36Sulfur metabolism_Homo sapiens_hsa009201.30368323
37Starch and sucrose metabolism_Homo sapiens_hsa005001.29884272
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28839372
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.27302122
40Staphylococcus aureus infection_Homo sapiens_hsa051501.25205644
41Propanoate metabolism_Homo sapiens_hsa006401.22336285
42Butanoate metabolism_Homo sapiens_hsa006501.22300198
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20647962
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20633327
45Estrogen signaling pathway_Homo sapiens_hsa049151.16862710
46Choline metabolism in cancer_Homo sapiens_hsa052311.16013673
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14631057
48Type II diabetes mellitus_Homo sapiens_hsa049301.13931776
49Hepatitis C_Homo sapiens_hsa051601.11598838
50Hepatitis B_Homo sapiens_hsa051611.11241362
51Inositol phosphate metabolism_Homo sapiens_hsa005621.08695400
52Colorectal cancer_Homo sapiens_hsa052101.03192243
53GnRH signaling pathway_Homo sapiens_hsa049121.01840742
54Peroxisome_Homo sapiens_hsa041460.99151216
55mTOR signaling pathway_Homo sapiens_hsa041500.99095008
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.98559944
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.97443670
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.96378909
59beta-Alanine metabolism_Homo sapiens_hsa004100.94015456
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93702820
61Biosynthesis of amino acids_Homo sapiens_hsa012300.92194013
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92002136
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89258467
64Phenylalanine metabolism_Homo sapiens_hsa003600.87643822
65TNF signaling pathway_Homo sapiens_hsa046680.87355803
66T cell receptor signaling pathway_Homo sapiens_hsa046600.86613947
67Glycerolipid metabolism_Homo sapiens_hsa005610.86535808
68Fructose and mannose metabolism_Homo sapiens_hsa000510.86041556
69Osteoclast differentiation_Homo sapiens_hsa043800.85954871
70Influenza A_Homo sapiens_hsa051640.85397845
71Histidine metabolism_Homo sapiens_hsa003400.85069162
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.84727115
73Adherens junction_Homo sapiens_hsa045200.84183582
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83248699
75Glucagon signaling pathway_Homo sapiens_hsa049220.82279389
76AMPK signaling pathway_Homo sapiens_hsa041520.82191316
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80399931
78One carbon pool by folate_Homo sapiens_hsa006700.76606248
79Apoptosis_Homo sapiens_hsa042100.76569286
80Carbon metabolism_Homo sapiens_hsa012000.76287562
81Viral carcinogenesis_Homo sapiens_hsa052030.75875788
82Chemical carcinogenesis_Homo sapiens_hsa052040.75832517
83Pyruvate metabolism_Homo sapiens_hsa006200.75418880
84HIF-1 signaling pathway_Homo sapiens_hsa040660.75305236
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74444965
86Chronic myeloid leukemia_Homo sapiens_hsa052200.74076654
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.72545514
88Protein digestion and absorption_Homo sapiens_hsa049740.72216952
89Retinol metabolism_Homo sapiens_hsa008300.71279297
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70618646
91Endocytosis_Homo sapiens_hsa041440.70607699
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69271741
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69267734
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.68406154
95HTLV-I infection_Homo sapiens_hsa051660.65719190
96Insulin signaling pathway_Homo sapiens_hsa049100.65647666
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65333930
98Tyrosine metabolism_Homo sapiens_hsa003500.64673855
99Measles_Homo sapiens_hsa051620.64363495
100Long-term potentiation_Homo sapiens_hsa047200.63833519
101Platelet activation_Homo sapiens_hsa046110.63241324
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.63179521
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62860169
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61829177
105Pathways in cancer_Homo sapiens_hsa052000.61731128
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.61657410
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60059472
108Fatty acid biosynthesis_Homo sapiens_hsa000610.59814734
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59561705
110Vitamin digestion and absorption_Homo sapiens_hsa049770.58595083
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58566067
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.58027193
113Focal adhesion_Homo sapiens_hsa045100.57350327
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56636816
115Endometrial cancer_Homo sapiens_hsa052130.55875381
116Small cell lung cancer_Homo sapiens_hsa052220.55665402
117Melanoma_Homo sapiens_hsa052180.54795110
118Vibrio cholerae infection_Homo sapiens_hsa051100.54545084
119Galactose metabolism_Homo sapiens_hsa000520.54534591
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.53401084
121Melanogenesis_Homo sapiens_hsa049160.53219895
122Proteoglycans in cancer_Homo sapiens_hsa052050.53101256
123Shigellosis_Homo sapiens_hsa051310.52588380
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52164679
125Prolactin signaling pathway_Homo sapiens_hsa049170.51945199
126Lysosome_Homo sapiens_hsa041420.51549461
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.51267985
128Prostate cancer_Homo sapiens_hsa052150.51209892
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51138523
130Rap1 signaling pathway_Homo sapiens_hsa040150.49824704
131Dorso-ventral axis formation_Homo sapiens_hsa043200.49308874
132Amoebiasis_Homo sapiens_hsa051460.48425788
133Folate biosynthesis_Homo sapiens_hsa007900.48191954
134Pancreatic cancer_Homo sapiens_hsa052120.48165997
135ECM-receptor interaction_Homo sapiens_hsa045120.47334081
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.46298712
137Bladder cancer_Homo sapiens_hsa052190.46111166
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45103549
139Salmonella infection_Homo sapiens_hsa051320.43984296
140MAPK signaling pathway_Homo sapiens_hsa040100.43845736
141Acute myeloid leukemia_Homo sapiens_hsa052210.43178175
142Chemokine signaling pathway_Homo sapiens_hsa040620.42812392
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42587152
144Prion diseases_Homo sapiens_hsa050200.41832951
145Thyroid hormone synthesis_Homo sapiens_hsa049180.37967631
146Notch signaling pathway_Homo sapiens_hsa043300.37732058
147Non-small cell lung cancer_Homo sapiens_hsa052230.37679096
148MicroRNAs in cancer_Homo sapiens_hsa052060.37251718
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37095576
150FoxO signaling pathway_Homo sapiens_hsa040680.36652862
151Pentose phosphate pathway_Homo sapiens_hsa000300.35866435
152Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34428868
153Toxoplasmosis_Homo sapiens_hsa051450.32815498
154Renin-angiotensin system_Homo sapiens_hsa046140.32504624
155N-Glycan biosynthesis_Homo sapiens_hsa005100.29950935
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29456309
157Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27724552

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