SEC16B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.86070701
2exogenous drug catabolic process (GO:0042738)7.62830920
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.35053708
4L-phenylalanine catabolic process (GO:0006559)7.35053708
5L-phenylalanine metabolic process (GO:0006558)6.98355329
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.98355329
7omega-hydroxylase P450 pathway (GO:0097267)6.77891250
8aromatic amino acid family catabolic process (GO:0009074)6.58508168
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.35930368
10tryptophan catabolic process (GO:0006569)5.94512750
11indole-containing compound catabolic process (GO:0042436)5.94512750
12indolalkylamine catabolic process (GO:0046218)5.94512750
13kynurenine metabolic process (GO:0070189)5.81844418
14drug metabolic process (GO:0017144)5.76673865
15bile acid biosynthetic process (GO:0006699)5.68330604
16tryptophan metabolic process (GO:0006568)5.61476120
17alpha-linolenic acid metabolic process (GO:0036109)5.56534437
18urea cycle (GO:0000050)5.50028991
19urea metabolic process (GO:0019627)5.50028991
20glyoxylate metabolic process (GO:0046487)5.43831705
21high-density lipoprotein particle remodeling (GO:0034375)5.42799059
22negative regulation of fibrinolysis (GO:0051918)5.30583340
23protein carboxylation (GO:0018214)5.22977147
24peptidyl-glutamic acid carboxylation (GO:0017187)5.22977147
25complement activation, alternative pathway (GO:0006957)5.18888907
26regulation of fibrinolysis (GO:0051917)5.17169630
27regulation of protein activation cascade (GO:2000257)5.16082309
28sulfur amino acid catabolic process (GO:0000098)5.11716180
29cysteine metabolic process (GO:0006534)5.09950849
30nitrogen cycle metabolic process (GO:0071941)5.04006397
31bile acid metabolic process (GO:0008206)4.94713686
32regulation of triglyceride catabolic process (GO:0010896)4.89895968
33regulation of cholesterol esterification (GO:0010872)4.84755929
34reverse cholesterol transport (GO:0043691)4.83351982
35regulation of complement activation (GO:0030449)4.81422293
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.80560644
37serine family amino acid catabolic process (GO:0009071)4.79473923
38aromatic amino acid family metabolic process (GO:0009072)4.76635965
39homocysteine metabolic process (GO:0050667)4.73559294
40ethanol metabolic process (GO:0006067)4.72669213
41phospholipid efflux (GO:0033700)4.69968795
42plasma lipoprotein particle remodeling (GO:0034369)4.69269980
43protein-lipid complex remodeling (GO:0034368)4.69269980
44macromolecular complex remodeling (GO:0034367)4.69269980
45triglyceride homeostasis (GO:0070328)4.65799715
46acylglycerol homeostasis (GO:0055090)4.65799715
47tyrosine metabolic process (GO:0006570)4.63576263
48oxidative demethylation (GO:0070989)4.55053167
49bile acid and bile salt transport (GO:0015721)4.53420040
50negative regulation of cholesterol transport (GO:0032375)4.47754101
51negative regulation of sterol transport (GO:0032372)4.47754101
52lysine metabolic process (GO:0006553)4.42225505
53lysine catabolic process (GO:0006554)4.42225505
54amino-acid betaine metabolic process (GO:0006577)4.41934757
55alpha-amino acid catabolic process (GO:1901606)4.41864734
56plasma lipoprotein particle clearance (GO:0034381)4.31075284
57cholesterol efflux (GO:0033344)4.27438578
58coenzyme catabolic process (GO:0009109)4.26642805
59indolalkylamine metabolic process (GO:0006586)4.25473081
60cellular ketone body metabolic process (GO:0046950)4.20410530
61fat-soluble vitamin biosynthetic process (GO:0042362)4.20307018
62hormone catabolic process (GO:0042447)4.19155425
63negative regulation of hemostasis (GO:1900047)4.18997973
64negative regulation of blood coagulation (GO:0030195)4.18997973
65regulation of plasminogen activation (GO:0010755)4.17975171
66imidazole-containing compound metabolic process (GO:0052803)4.16544521
67cellular glucuronidation (GO:0052695)4.15961855
68amine catabolic process (GO:0009310)4.11984347
69cellular biogenic amine catabolic process (GO:0042402)4.11984347
70intestinal cholesterol absorption (GO:0030299)4.08564874
71cellular amino acid catabolic process (GO:0009063)4.07067875
72plasma lipoprotein particle assembly (GO:0034377)4.06312280
73glycine metabolic process (GO:0006544)4.05426512
74negative regulation of protein activation cascade (GO:2000258)4.04554582
75glutamate metabolic process (GO:0006536)4.02682071
76flavonoid metabolic process (GO:0009812)4.00829632
77acute-phase response (GO:0006953)4.00811325
78positive regulation of triglyceride lipase activity (GO:0061365)3.98542813
79positive regulation of lipoprotein lipase activity (GO:0051006)3.98542813
80drug catabolic process (GO:0042737)3.97031860
81regulation of bile acid biosynthetic process (GO:0070857)3.96166288
82benzene-containing compound metabolic process (GO:0042537)3.96006086
83phenylpropanoid metabolic process (GO:0009698)3.91715735
84cellular modified amino acid catabolic process (GO:0042219)3.90073341
85regulation of humoral immune response (GO:0002920)3.88929442
86serine family amino acid metabolic process (GO:0009069)3.87468350
87alkaloid metabolic process (GO:0009820)3.87007686
88negative regulation of coagulation (GO:0050819)3.86990418
89regulation of cholesterol homeostasis (GO:2000188)3.83951717
90fibrinolysis (GO:0042730)3.82989442
91ethanol oxidation (GO:0006069)3.82290209
92cholesterol homeostasis (GO:0042632)3.81712904
93low-density lipoprotein particle remodeling (GO:0034374)3.80430529
94arginine metabolic process (GO:0006525)3.80053941
95positive regulation of lipid catabolic process (GO:0050996)3.79004751
96very-low-density lipoprotein particle assembly (GO:0034379)3.78891931
97intestinal absorption (GO:0050892)3.78545457
98regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.77811216
99phospholipid homeostasis (GO:0055091)3.75887032
100sterol homeostasis (GO:0055092)3.75695764
101negative regulation of wound healing (GO:0061045)3.75685252
102dicarboxylic acid biosynthetic process (GO:0043650)3.73871347
103serine family amino acid biosynthetic process (GO:0009070)3.72301469
104glucuronate metabolic process (GO:0019585)3.68571157
105uronic acid metabolic process (GO:0006063)3.68571157
106protein-lipid complex assembly (GO:0065005)3.66797814
107aldehyde catabolic process (GO:0046185)3.65240270
108complement activation, classical pathway (GO:0006958)3.62676646
109ketone body metabolic process (GO:1902224)3.62610725
110plasma lipoprotein particle organization (GO:0071827)3.61434312
111lipoprotein metabolic process (GO:0042157)3.60851537
112negative regulation of lipase activity (GO:0060192)3.60751260
113cofactor catabolic process (GO:0051187)3.60540101
114organic acid catabolic process (GO:0016054)3.60006129
115carboxylic acid catabolic process (GO:0046395)3.60006129
116blood coagulation, intrinsic pathway (GO:0007597)3.59259700
117complement activation (GO:0006956)3.58034462
118protein activation cascade (GO:0072376)3.56667149
119acetyl-CoA metabolic process (GO:0006084)3.54807836
120opsonization (GO:0008228)3.50823184
121cytolysis (GO:0019835)3.49702469
122drug transmembrane transport (GO:0006855)3.48532302
123regulation of apoptotic cell clearance (GO:2000425)3.46480961
124response to mercury ion (GO:0046689)3.40549388
125polyketide metabolic process (GO:0030638)3.37621863
126doxorubicin metabolic process (GO:0044598)3.37621863
127daunorubicin metabolic process (GO:0044597)3.37621863
128negative regulation of complement activation (GO:0045916)3.37406371
129angiotensin maturation (GO:0002003)3.33104958
130protein-lipid complex subunit organization (GO:0071825)3.31591877
131primary alcohol catabolic process (GO:0034310)3.29580867
132positive regulation of blood coagulation (GO:0030194)3.27745207
133positive regulation of hemostasis (GO:1900048)3.27745207
134positive regulation of fatty acid biosynthetic process (GO:0045723)3.26892972
135xenobiotic metabolic process (GO:0006805)3.24703737
136drug transport (GO:0015893)3.24622834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.16163280
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.98748510
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.72549481
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.41224172
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.08886896
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.86515802
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.66072514
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.09900620
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.74628840
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.07061535
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00338735
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4412171
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97492677
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72853306
15GATA1_22025678_ChIP-Seq_K562_Human1.72150549
16CLOCK_20551151_ChIP-Seq_293T_Human1.70099691
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.68716261
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64315311
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.56353348
20HTT_18923047_ChIP-ChIP_STHdh_Human1.47490504
21* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44828394
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40624382
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28601189
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20750414
25* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19978257
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10916578
27RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10255384
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09785611
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07896009
30GATA4_25053715_ChIP-Seq_YYC3_Human1.03652008
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03327001
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.02509001
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00978143
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98867388
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95069697
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94187389
37DROSHA_22980978_ChIP-Seq_HELA_Human0.92057097
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91286162
39TP63_17297297_ChIP-ChIP_HaCaT_Human0.89454840
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89021810
41CJUN_26792858_Chip-Seq_BT549_Human0.88202715
42* IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86223183
43IRF8_22096565_ChIP-ChIP_GC-B_Human0.84725195
44EP300_21415370_ChIP-Seq_HL-1_Mouse0.83264777
45* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83049600
46TBX20_22328084_ChIP-Seq_HEART_Mouse0.80839183
47TBX20_22080862_ChIP-Seq_HEART_Mouse0.80839183
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80596060
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80152143
50SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79558902
51AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79451200
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79426963
53NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79426963
54* CTCF_27219007_Chip-Seq_Bcells_Human0.79400865
55ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79239302
56* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77575844
57ESR2_21235772_ChIP-Seq_MCF-7_Human0.76784675
58* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75528065
59RARA_24833708_ChIP-Seq_LIVER_Mouse0.74342927
60* GATA2_21666600_ChIP-Seq_HMVEC_Human0.74076259
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.74064718
62NFIB_24661679_ChIP-Seq_LUNG_Mouse0.72451390
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72381255
64* TP53_18474530_ChIP-ChIP_U2OS_Human0.71034766
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71014269
66PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.68812810
67* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68550212
68CDX2_20551321_ChIP-Seq_CACO-2_Human0.68539459
69DNAJC2_21179169_ChIP-ChIP_NT2_Human0.68521903
70FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67883443
71CTNNB1_20460455_ChIP-Seq_HCT116_Human0.67538265
72ESR1_21235772_ChIP-Seq_MCF-7_Human0.66950662
73FOXA1_25552417_ChIP-Seq_VCAP_Human0.66739079
74SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65852077
75P63_26484246_Chip-Seq_KERATINOCYTES_Human0.65418672
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.64520862
77RACK7_27058665_Chip-Seq_MCF-7_Human0.63720651
78PIAS1_25552417_ChIP-Seq_VCAP_Human0.62950172
79SMC4_20622854_ChIP-Seq_HELA_Human0.62463811
80RARB_24833708_ChIP-Seq_LIVER_Mouse0.62241661
81* HNFA_21074721_ChIP-Seq_CACO-2_Human0.62186456
82RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61802157
83ERG_21242973_ChIP-ChIP_JURKAT_Human0.61039777
84RXR_22108803_ChIP-Seq_LS180_Human0.61017363
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60794939
86SOX9_24532713_ChIP-Seq_HFSC_Mouse0.60600449
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.59959446
88PPAR_26484153_Chip-Seq_NCI-H1993_Human0.59837849
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.58975010
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.58848687
91JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.58549300
92SOX2_20726797_ChIP-Seq_SW620_Human0.58027569
93FOXO3_23340844_ChIP-Seq_DLD1_Human0.57639673
94GATA6_25053715_ChIP-Seq_YYC3_Human0.56762652
95AR_20517297_ChIP-Seq_VCAP_Human0.56343320
96CEBPB_22108803_ChIP-Seq_LS180_Human0.56310817
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55658582
98ZNF263_19887448_ChIP-Seq_K562_Human0.54842527
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.54190550
100MYC_19915707_ChIP-ChIP_AK7_Human0.53979820
101* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53259198
102CBP_21632823_ChIP-Seq_H3396_Human0.52150394
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.51931798
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.51824711
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51597075
106* STAT1_17558387_ChIP-Seq_HELA_Human0.51011352
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.50997518
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.50772607
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.50521489
110GATA2_19941826_ChIP-Seq_K562_Human0.49251297
111GATA1_19941826_ChIP-Seq_K562_Human0.48563972
112LXR_22292898_ChIP-Seq_THP-1_Human0.48521684
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.47292565
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.47257480
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.47251575
116BCAT_22108803_ChIP-Seq_LS180_Human0.46846555
117* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.46521670
118* ESET_19884257_ChIP-Seq_ESCs_Mouse0.46509085
119* P53_21459846_ChIP-Seq_SAOS-2_Human0.44845116
120EGR1_19032775_ChIP-ChIP_M12_Human0.44687341
121CDX2_22108803_ChIP-Seq_LS180_Human0.44643558
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.44115341
123GATA3_24758297_ChIP-Seq_MCF-7_Human0.43574698
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42232456
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41282783
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.40870637
127ERG_20517297_ChIP-Seq_VCAP_Human0.40177591
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.39982418
129* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.39203836
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.38575579
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.37569442
132MYC_27129775_Chip-Seq_CORNEA_Mouse0.37263768
133* TAF2_19829295_ChIP-Seq_ESCs_Human0.37172775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.17091069
2MP0005360_urolithiasis7.53174706
3MP0005085_abnormal_gallbladder_physiolo6.33283910
4MP0005365_abnormal_bile_salt6.03642725
5MP0008875_abnormal_xenobiotic_pharmacok4.94061114
6MP0003252_abnormal_bile_duct4.11646124
7MP0003806_abnormal_nucleotide_metabolis4.04973216
8MP0010329_abnormal_lipoprotein_level3.57129676
9MP0009840_abnormal_foam_cell3.28993896
10MP0005083_abnormal_biliary_tract2.98078519
11MP0001666_abnormal_nutrient_absorption2.95459222
12MP0003195_calcinosis2.94035431
13MP0005332_abnormal_amino_acid2.64481960
14MP0003191_abnormal_cellular_cholesterol2.27812146
15MP0000609_abnormal_liver_physiology2.14326757
16MP0002118_abnormal_lipid_homeostasis2.12690409
17MP0004019_abnormal_vitamin_homeostasis2.09518094
18MP0003868_abnormal_feces_composition1.96386963
19MP0002138_abnormal_hepatobiliary_system1.90380621
20MP0005319_abnormal_enzyme/_coenzyme1.76146124
21MP0001764_abnormal_homeostasis1.61988226
22MP0009697_abnormal_copulation1.55557021
23MP0005584_abnormal_enzyme/coenzyme_acti1.43486644
24MP0005451_abnormal_body_composition1.38070799
25MP0003705_abnormal_hypodermis_morpholog1.34103705
26MP0003879_abnormal_hair_cell1.28618713
27MP0009643_abnormal_urine_homeostasis1.27268280
28MP0003183_abnormal_peptide_metabolism1.17451433
29MP0000598_abnormal_liver_morphology1.13294374
30MP0003011_delayed_dark_adaptation1.12557567
31MP0003656_abnormal_erythrocyte_physiolo1.11014648
32MP0003186_abnormal_redox_activity1.08863207
33MP0002254_reproductive_system_inflammat1.04518068
34MP0005647_abnormal_sex_gland1.03631504
35MP0005670_abnormal_white_adipose0.97364929
36MP0009764_decreased_sensitivity_to0.95848945
37MP0009763_increased_sensitivity_to0.94137452
38MP0000604_amyloidosis0.94016109
39MP0005220_abnormal_exocrine_pancreas0.93117479
40MP0005084_abnormal_gallbladder_morpholo0.92611239
41MP0002132_abnormal_respiratory_system0.92406418
42MP0004272_abnormal_basement_membrane0.91957952
43MP0005636_abnormal_mineral_homeostasis0.91653972
44MP0002078_abnormal_glucose_homeostasis0.91320669
45MP0010368_abnormal_lymphatic_system0.90098730
46MP0009780_abnormal_chondrocyte_physiolo0.89474069
47MP0005409_darkened_coat_color0.89405678
48MP0005408_hypopigmentation0.89067887
49MP0009642_abnormal_blood_homeostasis0.87590756
50MP0002876_abnormal_thyroid_physiology0.86178425
51MP0008469_abnormal_protein_level0.83392480
52MP0005334_abnormal_fat_pad0.77730425
53MP0002971_abnormal_brown_adipose0.77121888
54MP0005376_homeostasis/metabolism_phenot0.76548440
55MP0001661_extended_life_span0.74876435
56MP0009765_abnormal_xenobiotic_induced0.73530233
57MP0005448_abnormal_energy_balance0.70667115
58MP0005023_abnormal_wound_healing0.69594753
59MP0006036_abnormal_mitochondrial_physio0.68902325
60MP0005535_abnormal_body_temperature0.67601944
61MP0004130_abnormal_muscle_cell0.66603156
62MP0010155_abnormal_intestine_physiology0.65384260
63MP0000566_synostosis0.64935667
64MP0001664_abnormal_digestion0.64458003
65MP0001756_abnormal_urination0.63422179
66MP0006138_congestive_heart_failure0.62044269
67MP0005266_abnormal_metabolism0.60453461
68MP0002249_abnormal_larynx_morphology0.60300359
69MP0000639_abnormal_adrenal_gland0.57595350
70MP0005330_cardiomyopathy0.57272351
71MP0004264_abnormal_extraembryonic_tissu0.56099038
72MP0009053_abnormal_anal_canal0.56070714
73MP0002837_dystrophic_cardiac_calcinosis0.55494289
74MP0000751_myopathy0.55057992
75MP0003690_abnormal_glial_cell0.54947168
76MP0009384_cardiac_valve_regurgitation0.54247065
77MP0002928_abnormal_bile_duct0.53890507
78MP0004036_abnormal_muscle_relaxation0.52675330
79MP0005395_other_phenotype0.51683372
80MP0003953_abnormal_hormone_level0.49137144
81MP0003329_amyloid_beta_deposits0.49021847
82MP0005666_abnormal_adipose_tissue0.48851012
83MP0003724_increased_susceptibility_to0.48819611
84MP0008438_abnormal_cutaneous_collagen0.48293123
85MP0002822_catalepsy0.47785784
86MP0004147_increased_porphyrin_level0.47049342
87MP0002060_abnormal_skin_morphology0.45904608
88MP0005164_abnormal_response_to0.45892825
89MP0005464_abnormal_platelet_physiology0.45663980
90MP0002136_abnormal_kidney_physiology0.44910289
91MP0001944_abnormal_pancreas_morphology0.44436617
92MP0003638_abnormal_response/metabolism_0.44026044
93MP0000013_abnormal_adipose_tissue0.43924114
94MP0003718_maternal_effect0.43900107
95MP0004782_abnormal_surfactant_physiolog0.43150553
96MP0006035_abnormal_mitochondrial_morpho0.42866672
97MP0008004_abnormal_stomach_pH0.42380704
98MP0001243_abnormal_dermal_layer0.42334276
99MP0001915_intracranial_hemorrhage0.41959429
100MP0008775_abnormal_heart_ventricle0.41708340
101MP0000579_abnormal_nail_morphology0.41181990
102MP0001881_abnormal_mammary_gland0.40745505
103MP0001765_abnormal_ion_homeostasis0.40657016
104MP0008873_increased_physiological_sensi0.40213169
105MP0009115_abnormal_fat_cell0.39613112
106MP0005248_abnormal_Harderian_gland0.39414106
107MP0002089_abnormal_postnatal_growth/wei0.39296870
108MP0002896_abnormal_bone_mineralization0.38736060
109MP0002168_other_aberrant_phenotype0.38628245
110MP0008872_abnormal_physiological_respon0.38479502
111MP0005375_adipose_tissue_phenotype0.38392945
112MP0010386_abnormal_urinary_bladder0.37506013
113MP0002796_impaired_skin_barrier0.36876779
114MP0000230_abnormal_systemic_arterial0.36726198
115MP0003436_decreased_susceptibility_to0.35701648
116MP0002269_muscular_atrophy0.35680006
117MP0004084_abnormal_cardiac_muscle0.35388437
118MP0001501_abnormal_sleep_pattern0.35327042
119MP0000678_abnormal_parathyroid_gland0.34973318
120MP0005166_decreased_susceptibility_to0.33986461
121MP0009672_abnormal_birth_weight0.33751892
122MP0002970_abnormal_white_adipose0.33553439
123MP0008874_decreased_physiological_sensi0.32483460
124MP0003075_altered_response_to0.31805085
125MP0003300_gastrointestinal_ulcer0.31739991
126MP0005058_abnormal_lysosome_morphology0.31645900
127MP0000249_abnormal_blood_vessel0.30891792
128MP0010234_abnormal_vibrissa_follicle0.30703987
129MP0004043_abnormal_pH_regulation0.30483377
130MP0000538_abnormal_urinary_bladder0.28117463
131MP0002693_abnormal_pancreas_physiology0.27633684

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.27462255
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.22542179
3Deep venous thrombosis (HP:0002625)7.08479648
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.57380388
5Hypobetalipoproteinemia (HP:0003563)6.44265811
6Prolonged partial thromboplastin time (HP:0003645)6.37901997
7Xanthomatosis (HP:0000991)6.33335288
8Hyperlipoproteinemia (HP:0010980)5.33007057
9Complement deficiency (HP:0004431)5.24208237
10Hypolipoproteinemia (HP:0010981)4.86546643
11Abnormality of the common coagulation pathway (HP:0010990)4.56970683
12Epidermoid cyst (HP:0200040)4.53738885
13Joint hemorrhage (HP:0005261)4.52151139
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.44704604
15Hyperammonemia (HP:0001987)4.36707517
16Fat malabsorption (HP:0002630)4.28651283
17Hypoglycemic coma (HP:0001325)4.28451460
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.25044707
19Hypoalphalipoproteinemia (HP:0003233)4.23225404
20Ketosis (HP:0001946)4.21003340
21Conjugated hyperbilirubinemia (HP:0002908)4.20052928
22Hyperglycinemia (HP:0002154)4.19890736
23Abnormality of sulfur amino acid metabolism (HP:0004339)4.10138775
24Abnormality of methionine metabolism (HP:0010901)3.97838165
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97546101
26Nephritis (HP:0000123)3.95149005
27Abnormality of the intrinsic pathway (HP:0010989)3.94844846
28Hyperglycinuria (HP:0003108)3.84888432
29Abnormality of complement system (HP:0005339)3.82818940
30Abnormality of glycine metabolism (HP:0010895)3.78694776
31Abnormality of serine family amino acid metabolism (HP:0010894)3.78694776
32Hypercholesterolemia (HP:0003124)3.63583926
33Abnormality of pyrimidine metabolism (HP:0004353)3.51330664
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36993598
35Hyperbilirubinemia (HP:0002904)3.30433628
36Abnormality of fatty-acid metabolism (HP:0004359)3.28429877
37Ketoacidosis (HP:0001993)3.21224544
38Myocardial infarction (HP:0001658)3.07212405
39Abnormality of nucleobase metabolism (HP:0010932)3.07206153
40Steatorrhea (HP:0002570)3.04496941
41Hypoglycemic seizures (HP:0002173)2.98907323
42Skin nodule (HP:0200036)2.98779436
43Spontaneous abortion (HP:0005268)2.98335001
44Hepatocellular carcinoma (HP:0001402)2.92001573
45Abnormality of purine metabolism (HP:0004352)2.85143897
46Abnormality of serum amino acid levels (HP:0003112)2.82898163
47Delayed CNS myelination (HP:0002188)2.82697875
48Acanthocytosis (HP:0001927)2.81690550
49Hypochromic microcytic anemia (HP:0004840)2.70938585
50Metabolic acidosis (HP:0001942)2.68051901
51Systemic lupus erythematosus (HP:0002725)2.63060888
52Hyperinsulinemic hypoglycemia (HP:0000825)2.58490614
53Malnutrition (HP:0004395)2.56494721
54Vascular calcification (HP:0004934)2.50240746
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48199478
56Dicarboxylic aciduria (HP:0003215)2.48199478
57Mitral stenosis (HP:0001718)2.48127294
58Gout (HP:0001997)2.44542455
59Abnormal gallbladder morphology (HP:0012437)2.42969674
60Lethargy (HP:0001254)2.40461366
61Glomerulonephritis (HP:0000099)2.34082295
62Irritability (HP:0000737)2.31941268
63Cardiovascular calcification (HP:0011915)2.31257540
64Cholelithiasis (HP:0001081)2.30440016
65Generalized aminoaciduria (HP:0002909)2.30316011
66Hyperglycemia (HP:0003074)2.30205409
67Late onset (HP:0003584)2.28559565
68Amyloidosis (HP:0011034)2.27137207
69Osteomalacia (HP:0002749)2.23054540
70Pancreatitis (HP:0001733)2.21905654
71Enlarged kidneys (HP:0000105)2.21039861
72Spastic diplegia (HP:0001264)2.20349873
73Symptomatic seizures (HP:0011145)2.20029161
74Recurrent gram-negative bacterial infections (HP:0005420)2.19315681
75Purpura (HP:0000979)2.18889533
76Cholecystitis (HP:0001082)2.17645112
77Abnormal gallbladder physiology (HP:0012438)2.17645112
78Glycosuria (HP:0003076)2.14012429
79Abnormality of urine glucose concentration (HP:0011016)2.14012429
80Gingival bleeding (HP:0000225)2.12094431
81Potter facies (HP:0002009)2.12080152
82Facial shape deformation (HP:0011334)2.12080152
83Hydroxyprolinuria (HP:0003080)2.11942627
84Abnormality of proline metabolism (HP:0010907)2.11942627
85Cerebral edema (HP:0002181)2.11115657
86Sensorimotor neuropathy (HP:0007141)2.10011733
87Esophageal varix (HP:0002040)2.09622471
88Poikilocytosis (HP:0004447)2.08287812
89Menorrhagia (HP:0000132)2.07656469
90Brushfield spots (HP:0001088)2.07542512
91Neonatal onset (HP:0003623)2.06467532
92Hemorrhage of the eye (HP:0011885)2.04735701
93Rickets (HP:0002748)1.99223669
94Opisthotonus (HP:0002179)1.98354271
95Renal cortical cysts (HP:0000803)1.97732640
96Abnormality of the gallbladder (HP:0005264)1.96121392
97Widely patent fontanelles and sutures (HP:0004492)1.95984047
98Hypophosphatemia (HP:0002148)1.95854588
99Ileus (HP:0002595)1.95762093
100Abnormal cartilage morphology (HP:0002763)1.95668013
101Vomiting (HP:0002013)1.94143783
102Thrombophlebitis (HP:0004418)1.93965580
103Nephrolithiasis (HP:0000787)1.89777686
104Abnormal enzyme/coenzyme activity (HP:0012379)1.89768390
105Pigmentary retinal degeneration (HP:0001146)1.88183607
106Abnormality of the Achilles tendon (HP:0005109)1.83559779
107Abnormality of transition element cation homeostasis (HP:0011030)1.83223100
108Hypophosphatemic rickets (HP:0004912)1.82859303
109Elevated alkaline phosphatase (HP:0003155)1.80261814
110Abnormality of iron homeostasis (HP:0011031)1.79697738
111Cerebral palsy (HP:0100021)1.78316227
112Hyperphosphaturia (HP:0003109)1.78298740
113Abnormality of vitamin metabolism (HP:0100508)1.77147818
114Focal segmental glomerulosclerosis (HP:0000097)1.77024742
115Elevated hepatic transaminases (HP:0002910)1.76952240
116Exercise-induced myalgia (HP:0003738)1.75539854
117Proximal tubulopathy (HP:0000114)1.74860275
118Increased purine levels (HP:0004368)1.74149998
119Reduced antithrombin III activity (HP:0001976)1.74135833
120Abnormality of alkaline phosphatase activity (HP:0004379)1.72959597
121Alkalosis (HP:0001948)1.71588720
122Protuberant abdomen (HP:0001538)1.69491217
123Hyperuricemia (HP:0002149)1.67001197
124Abnormal urine phosphate concentration (HP:0012599)1.65582291
125Fair hair (HP:0002286)1.64731182
126Pulmonary embolism (HP:0002204)1.62686419
127Abdominal distention (HP:0003270)1.56225104
128Glomerulosclerosis (HP:0000096)1.53463926
129Arthropathy (HP:0003040)1.52948756
130Abnormal delivery (HP:0001787)1.50520577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.04224051
2ERN14.59409696
3SIK14.46794543
4FGFR43.99779170
5INSRR3.98316488
6TAOK33.54957998
7MST1R3.22982791
8FRK2.74211346
9ERBB42.72218152
10MYLK2.48825646
11ACVR1B2.41008249
12OBSCN2.39234119
13LATS12.19872915
14FLT31.92208922
15PKN21.82465708
16LMTK21.80646928
17MAPK111.76743982
18MAP2K41.76611484
19PTK61.73905283
20PIK3CG1.73082634
21TRIB31.65631699
22MET1.52693074
23ICK1.52398616
24MAPK151.50779626
25TYK21.43065215
26DDR21.37407762
27NEK91.29932389
28CDC42BPA1.25739133
29ABL21.19356420
30PRKAA21.16941482
31NLK1.16728235
32JAK21.15705910
33DAPK21.12529984
34PIK3CA1.10344586
35EPHA41.09301715
36FGFR21.09180648
37EPHA31.08765243
38JAK11.05117026
39STK38L1.03834294
40MAP3K131.03602859
41MAPKAPK31.03057734
42IRAK31.03045979
43MAP3K70.99991451
44MAP3K20.99050492
45PRPF4B0.98764715
46MAP3K100.96768811
47FER0.96632815
48EEF2K0.90996818
49MAP3K140.90969019
50ERBB20.90881310
51KDR0.90281150
52PINK10.88867388
53EPHB10.88751547
54STK380.88496332
55PDK10.87544828
56TBK10.86854020
57PHKG20.84289597
58PHKG10.84289597
59GRK60.83881688
60TTN0.83528227
61MAP2K30.83082860
62CAMK1D0.82662518
63PTK20.82652367
64RIPK10.79264079
65MAP3K30.79199626
66TRPM70.76097494
67PRKCZ0.74568591
68PRKAA10.73703379
69DYRK1B0.71477857
70STK390.70839200
71GSK3A0.70185892
72NUAK10.68589761
73MAP2K20.67808074
74PRKACG0.66553225
75AKT30.66010870
76MAPK40.65145144
77CDK60.64727441
78MAP3K10.64640845
79FGFR30.63648788
80PDK20.63084342
81MAP2K10.62644315
82PRKG10.60932387
83TGFBR20.60412304
84CSK0.59555849
85RET0.58096680
86SGK30.56441091
87PDGFRA0.55498551
88CAMK2G0.53896442
89TIE10.53687589
90ZAP700.53603967
91PDGFRB0.53285683
92IRAK10.49799271
93MAP2K60.48914539
94MAPK120.48909300
95IGF1R0.48463316
96MUSK0.47671070
97NTRK30.47267402
98ROCK10.46566971
99PDPK10.43760513
100OXSR10.43164308
101PRKCQ0.42715448
102CAMK2D0.40725939
103MTOR0.40463665
104STK240.40415731
105MAP3K110.40005433
106SRC0.39483703
107MAPK70.38587530
108STK30.38361812
109SGK20.38165283
110PRKACA0.38147753
111GRK10.35209306
112IKBKE0.34319668
113PRKG20.33810177
114CAMK1G0.33051061
115AKT20.32931414
116SGK10.32445556
117MELK0.32388563
118KSR20.31546765
119EPHB20.31502135
120MAP3K50.31475436
121CSF1R0.31392583
122CSNK1G10.30540617
123PRKCH0.29801889
124LATS20.29294832
125PAK30.28030915
126EPHA20.27833555
127PRKCA0.24876693
128IRAK20.24687036
129BMX0.24225458
130CHUK0.24077276
131PKN10.23760799
132SGK2230.23147379
133SGK4940.23147379
134MAP3K60.22092295
135ABL10.21122861
136EGFR0.19994673
137CDK40.19868991

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39084971
2Nitrogen metabolism_Homo sapiens_hsa009103.45316708
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29842065
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.14846574
5Arginine biosynthesis_Homo sapiens_hsa002202.94776647
6Tryptophan metabolism_Homo sapiens_hsa003802.73667966
7Complement and coagulation cascades_Homo sapiens_hsa046102.68410316
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61485730
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49591720
10Fatty acid degradation_Homo sapiens_hsa000712.48738538
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42660447
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35868443
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20832222
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10592876
15Butanoate metabolism_Homo sapiens_hsa006502.09914574
16Peroxisome_Homo sapiens_hsa041462.04512387
17Histidine metabolism_Homo sapiens_hsa003401.97131749
18PPAR signaling pathway_Homo sapiens_hsa033201.91790320
19Chemical carcinogenesis_Homo sapiens_hsa052041.88704199
20Propanoate metabolism_Homo sapiens_hsa006401.85935468
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.85821010
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85798417
23Caffeine metabolism_Homo sapiens_hsa002321.84883818
24Fatty acid metabolism_Homo sapiens_hsa012121.79874913
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.73154526
26beta-Alanine metabolism_Homo sapiens_hsa004101.68723638
27Staphylococcus aureus infection_Homo sapiens_hsa051501.68442851
28Retinol metabolism_Homo sapiens_hsa008301.66595740
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65983540
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63738202
31Selenocompound metabolism_Homo sapiens_hsa004501.60525109
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.59490973
33Sulfur metabolism_Homo sapiens_hsa009201.58743507
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55456423
35Bile secretion_Homo sapiens_hsa049761.55265499
36Phenylalanine metabolism_Homo sapiens_hsa003601.53639814
37Fat digestion and absorption_Homo sapiens_hsa049751.51380804
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46516433
39Starch and sucrose metabolism_Homo sapiens_hsa005001.45090251
40Folate biosynthesis_Homo sapiens_hsa007901.41651888
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41647456
42Tyrosine metabolism_Homo sapiens_hsa003501.41430632
43Pyruvate metabolism_Homo sapiens_hsa006201.31302989
44ABC transporters_Homo sapiens_hsa020101.31039948
45Fatty acid elongation_Homo sapiens_hsa000621.26887931
46Steroid biosynthesis_Homo sapiens_hsa001001.20766780
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.18036470
48Biosynthesis of amino acids_Homo sapiens_hsa012301.10054297
49Vitamin digestion and absorption_Homo sapiens_hsa049771.07610953
50Carbon metabolism_Homo sapiens_hsa012001.05548729
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98292695
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.98157738
53Arginine and proline metabolism_Homo sapiens_hsa003300.97816852
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92122145
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89074604
56Vitamin B6 metabolism_Homo sapiens_hsa007500.88586030
57Sulfur relay system_Homo sapiens_hsa041220.88010240
58Lysine degradation_Homo sapiens_hsa003100.85265173
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82310248
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77550240
61Glycerolipid metabolism_Homo sapiens_hsa005610.75618675
62One carbon pool by folate_Homo sapiens_hsa006700.67265094
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66219046
64Glutathione metabolism_Homo sapiens_hsa004800.64979989
65Fatty acid biosynthesis_Homo sapiens_hsa000610.59301138
66Pentose phosphate pathway_Homo sapiens_hsa000300.51778010
67Other glycan degradation_Homo sapiens_hsa005110.51508152
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49665081
69Galactose metabolism_Homo sapiens_hsa000520.49604020
70Metabolic pathways_Homo sapiens_hsa011000.45066258
71Pertussis_Homo sapiens_hsa051330.41321450
72Prion diseases_Homo sapiens_hsa050200.38945222
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34735828
74Insulin resistance_Homo sapiens_hsa049310.31790928
75Fructose and mannose metabolism_Homo sapiens_hsa000510.29207824
76Linoleic acid metabolism_Homo sapiens_hsa005910.28234002
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.24047908
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.20206440
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13441825
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13355183
81Glucagon signaling pathway_Homo sapiens_hsa049220.13312094
82Pancreatic secretion_Homo sapiens_hsa049720.11297360
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09767526
84Sphingolipid metabolism_Homo sapiens_hsa006000.09587501
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.08188430
86Renin-angiotensin system_Homo sapiens_hsa046140.06601376
87AMPK signaling pathway_Homo sapiens_hsa041520.05130299
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.00661381
89Ether lipid metabolism_Homo sapiens_hsa005650.00622671
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00045797
91Amoebiasis_Homo sapiens_hsa05146-0.1879815
92Protein export_Homo sapiens_hsa03060-0.1694097
93Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1496556
94Hepatitis C_Homo sapiens_hsa05160-0.1480729
95African trypanosomiasis_Homo sapiens_hsa05143-0.1394310
96Bladder cancer_Homo sapiens_hsa05219-0.1344730
97Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1268202
98Regulation of autophagy_Homo sapiens_hsa04140-0.1182830
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1057826
100Type II diabetes mellitus_Homo sapiens_hsa04930-0.1010966
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0919507
102Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0905152
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0776235
104Insulin signaling pathway_Homo sapiens_hsa04910-0.0697993
105Mineral absorption_Homo sapiens_hsa04978-0.0504114
106ECM-receptor interaction_Homo sapiens_hsa04512-0.0424567
107Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0412426
108Protein digestion and absorption_Homo sapiens_hsa04974-0.0400557
109Serotonergic synapse_Homo sapiens_hsa04726-0.0344715
110Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0289244
111Renin secretion_Homo sapiens_hsa04924-0.0205200
112Circadian rhythm_Homo sapiens_hsa04710-0.0098323

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »