SEC23B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.43502178
2signal peptide processing (GO:0006465)5.98935436
3protein retention in ER lumen (GO:0006621)5.51449024
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.43360373
5COPII vesicle coating (GO:0048208)5.39230616
6protein maturation by protein folding (GO:0022417)5.16409038
7folic acid-containing compound biosynthetic process (GO:0009396)4.80552290
8activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.76389453
9positive regulation of nuclease activity (GO:0032075)4.73696368
10establishment of integrated proviral latency (GO:0075713)4.63276398
11regulation of nuclease activity (GO:0032069)4.44812190
12endoplasmic reticulum unfolded protein response (GO:0030968)4.22022418
13tRNA aminoacylation for protein translation (GO:0006418)4.13519554
14cellular response to unfolded protein (GO:0034620)4.10751675
15establishment of viral latency (GO:0019043)4.08820263
16vesicle coating (GO:0006901)4.07566614
17ER overload response (GO:0006983)4.06542546
18tRNA aminoacylation (GO:0043039)4.04982772
19amino acid activation (GO:0043038)4.04982772
20sequestering of metal ion (GO:0051238)4.02477009
21pteridine-containing compound biosynthetic process (GO:0042559)4.01764837
22endocrine pancreas development (GO:0031018)4.01098736
23exocrine pancreas development (GO:0031017)3.99799204
24ribosome assembly (GO:0042255)3.99592522
25nuclear pore complex assembly (GO:0051292)3.97023266
26cellular response to topologically incorrect protein (GO:0035967)3.96348173
27ER-nucleus signaling pathway (GO:0006984)3.90461547
28ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.81959715
29protein N-linked glycosylation via asparagine (GO:0018279)3.75907554
30proteasome assembly (GO:0043248)3.74230451
31peptidyl-asparagine modification (GO:0018196)3.71670345
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60065847
33nuclear pore organization (GO:0006999)3.59762614
34peptide catabolic process (GO:0043171)3.56954424
35regulation of translational fidelity (GO:0006450)3.55260299
36peptide hormone processing (GO:0016486)3.52668335
37intestinal cholesterol absorption (GO:0030299)3.51511397
38response to endoplasmic reticulum stress (GO:0034976)3.48809945
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48605392
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48070252
41protein N-linked glycosylation (GO:0006487)3.46579543
42nucleobase biosynthetic process (GO:0046112)3.42636152
43GDP-mannose metabolic process (GO:0019673)3.42038678
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.41199592
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37753389
46negative regulation of ligase activity (GO:0051352)3.37753389
47regulation of cellular amino acid metabolic process (GO:0006521)3.34829468
48pore complex assembly (GO:0046931)3.34259842
49double-strand break repair via nonhomologous end joining (GO:0006303)3.33060493
50non-recombinational repair (GO:0000726)3.33060493
51fatty acid elongation (GO:0030497)3.32597105
52L-alpha-amino acid transmembrane transport (GO:1902475)3.29176832
53response to unfolded protein (GO:0006986)3.25948920
54regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.25711079
55glandular epithelial cell differentiation (GO:0002067)3.22379306
56spliceosomal tri-snRNP complex assembly (GO:0000244)3.22074463
57UDP-N-acetylglucosamine metabolic process (GO:0006047)3.20217223
58proline biosynthetic process (GO:0006561)3.18443691
59response to topologically incorrect protein (GO:0035966)3.17095793
60tetrahydrofolate metabolic process (GO:0046653)3.14811615
61intestinal absorption (GO:0050892)3.12340506
62NADPH regeneration (GO:0006740)3.09957411
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09557457
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09557457
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07980876
66signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07510690
67signal transduction involved in DNA damage checkpoint (GO:0072422)3.07510690
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06843246
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06843246
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06843246
71* ER to Golgi vesicle-mediated transport (GO:0006888)3.01405793
72IMP biosynthetic process (GO:0006188)3.00531101
73signal transduction involved in cell cycle checkpoint (GO:0072395)3.00492195
74nucleotide-sugar biosynthetic process (GO:0009226)2.99442167
75positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98182783
76protein autoprocessing (GO:0016540)2.97791511
77chaperone mediated protein folding requiring cofactor (GO:0051085)2.93321822
78mitotic nuclear envelope disassembly (GO:0007077)2.92499549
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91899697
80tricarboxylic acid cycle (GO:0006099)2.91865211
81positive regulation of ligase activity (GO:0051351)2.89169962
82purine nucleobase biosynthetic process (GO:0009113)2.89065326
83ribosome biogenesis (GO:0042254)2.88996741
84nucleobase-containing small molecule interconversion (GO:0015949)2.86971534
854-hydroxyproline metabolic process (GO:0019471)2.86552304
86mitotic metaphase plate congression (GO:0007080)2.86070456
87de novo protein folding (GO:0006458)2.83629739
88long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.82834766
89regulation of mitochondrial translation (GO:0070129)2.80707757
90regulation of translational termination (GO:0006449)2.80223919
91regulation of type B pancreatic cell apoptotic process (GO:2000674)2.79949480
92de novo posttranslational protein folding (GO:0051084)2.79433805
93folic acid metabolic process (GO:0046655)2.78686509
94folic acid-containing compound metabolic process (GO:0006760)2.77086268
95regulation of translation in response to stress (GO:0043555)2.77051630
96valine metabolic process (GO:0006573)2.76568157
97pteridine-containing compound metabolic process (GO:0042558)2.74601396
98regulation of ubiquitin-protein transferase activity (GO:0051438)2.74280700
99cell redox homeostasis (GO:0045454)2.72970614
100cullin deneddylation (GO:0010388)2.72630060
101pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.71201651
102UMP metabolic process (GO:0046049)2.71201651
103pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.71201651
104UMP biosynthetic process (GO:0006222)2.71201651
105L-serine metabolic process (GO:0006563)2.70815424
106protein deneddylation (GO:0000338)2.70763563
107membrane disassembly (GO:0030397)2.69548096
108nuclear envelope disassembly (GO:0051081)2.69548096
109regulation of ligase activity (GO:0051340)2.67732510
110hyperosmotic salinity response (GO:0042538)2.67599326
111antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.67176556
112DNA ligation (GO:0006266)2.66766334
113regulation of response to tumor cell (GO:0002834)2.65570050
114positive regulation of response to tumor cell (GO:0002836)2.65570050
115positive regulation of immune response to tumor cell (GO:0002839)2.65570050
116regulation of immune response to tumor cell (GO:0002837)2.65570050
117spliceosomal snRNP assembly (GO:0000387)2.61269619
118formation of translation preinitiation complex (GO:0001731)2.61076279
119intestinal epithelial cell development (GO:0060576)2.60012050
120mitotic chromosome condensation (GO:0007076)2.59526941
121alpha-linolenic acid metabolic process (GO:0036109)2.59176236
122DNA strand elongation involved in DNA replication (GO:0006271)2.55747455
123pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.53834200
124mitochondrial DNA metabolic process (GO:0032042)2.53207893
125mitochondrial RNA metabolic process (GO:0000959)2.52884752
126peptidyl-arginine omega-N-methylation (GO:0035247)2.52039540
127metaphase plate congression (GO:0051310)2.51932317
128nucleotide transmembrane transport (GO:1901679)2.51238592
129intra-Golgi vesicle-mediated transport (GO:0006891)2.50497984
130mitotic sister chromatid segregation (GO:0000070)2.50460389
131glucose 6-phosphate metabolic process (GO:0051156)2.49814847
132telomere maintenance via recombination (GO:0000722)2.49528400
133regulation of translational elongation (GO:0006448)2.48834461
134regulation of cellular amine metabolic process (GO:0033238)2.48573815
135type B pancreatic cell development (GO:0003323)2.47910440
136IMP metabolic process (GO:0046040)2.46724533
137cellular response to glucose starvation (GO:0042149)2.46146477
138proline metabolic process (GO:0006560)2.45776295
139cell cycle G1/S phase transition (GO:0044843)2.44994878
140G1/S transition of mitotic cell cycle (GO:0000082)2.44994878
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.42772360
142L-phenylalanine catabolic process (GO:0006559)2.42772360
143DNA strand elongation (GO:0022616)2.41450255
144peptide metabolic process (GO:0006518)2.38692800
145pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.38537410
146L-phenylalanine metabolic process (GO:0006558)2.38122212
147erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.38122212
148nucleotide-sugar metabolic process (GO:0009225)2.37654661
149dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.37568125
150cellular zinc ion homeostasis (GO:0006882)2.37486168
151tricarboxylic acid metabolic process (GO:0072350)2.37137073
1523-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.37091477
153purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.37091477
154antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.36151962
155antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.36151962
156serine family amino acid biosynthetic process (GO:0009070)2.32990292
157negative regulation of glycoprotein biosynthetic process (GO:0010561)2.32361314
158DNA unwinding involved in DNA replication (GO:0006268)2.29853451
159chaperone-mediated protein folding (GO:0061077)2.29639118
160one-carbon metabolic process (GO:0006730)2.28815393
161hormone catabolic process (GO:0042447)2.26097904
162Golgi organization (GO:0007030)2.24826066
163glandular epithelial cell development (GO:0002068)2.24617523
164antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.24605130
165pentose-phosphate shunt (GO:0006098)2.24064926
166cysteine metabolic process (GO:0006534)2.24032217
167regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.23217477
168antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.23025651
169maintenance of protein localization in organelle (GO:0072595)2.23001044
170digestion (GO:0007586)2.22599339
171telomere maintenance via semi-conservative replication (GO:0032201)2.22459264
172positive regulation of insulin secretion (GO:0032024)2.21734225
173COPI coating of Golgi vesicle (GO:0048205)10.1515184
174Golgi transport vesicle coating (GO:0048200)10.1515184

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.39065540
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.13257732
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22586199
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89754662
5* GABP_17652178_ChIP-ChIP_JURKAT_Human2.88340484
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.83746799
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.70302137
8GATA1_22025678_ChIP-Seq_K562_Human2.57357797
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56619871
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.55348957
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47626070
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.40348750
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.38531088
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29609829
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.19121003
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04636027
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.00545574
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00395714
19MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99303137
20VDR_23849224_ChIP-Seq_CD4+_Human1.98747298
21DCP1A_22483619_ChIP-Seq_HELA_Human1.96973848
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94127220
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92884830
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91911135
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91087784
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87840566
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.87414349
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84817560
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80445171
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.80186271
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79688874
32* GABP_19822575_ChIP-Seq_HepG2_Human1.76924682
33* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74783062
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73008645
35FOXP3_21729870_ChIP-Seq_TREG_Human1.72748646
36TFEB_21752829_ChIP-Seq_HELA_Human1.72705613
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71419021
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.68292886
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67779782
40ZNF263_19887448_ChIP-Seq_K562_Human1.66834506
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64551548
42ELK1_19687146_ChIP-ChIP_HELA_Human1.64316961
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63967554
44XRN2_22483619_ChIP-Seq_HELA_Human1.62007541
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58459806
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58419211
47* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57571004
48AR_21909140_ChIP-Seq_LNCAP_Human1.54727867
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53860256
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52327155
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.52244043
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50320384
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49879401
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49336255
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48514655
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48362752
57KDM5A_27292631_Chip-Seq_BREAST_Human1.46544116
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.46213085
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45557211
60* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43791659
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42566518
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42293040
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38936522
64* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34601215
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34599850
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.34041703
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.33508013
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33005344
69* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32780190
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32605184
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27427566
72* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26525949
73* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25565199
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25369831
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25342148
76CIITA_25753668_ChIP-Seq_RAJI_Human1.25287843
77MYC_22102868_ChIP-Seq_BL_Human1.24117982
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24099921
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20545642
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18271638
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17304719
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12629223
83CLOCK_20551151_ChIP-Seq_293T_Human1.12064864
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10050303
85* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09382339
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07368674
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06063678
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03970375
89TTF2_22483619_ChIP-Seq_HELA_Human1.03688775
90SPI1_23547873_ChIP-Seq_NB4_Human1.03282857
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03124966
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02744609
93* YY1_21170310_ChIP-Seq_MESCs_Mouse1.02710833
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01660224
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00315909
96* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00258531
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.00214907
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97144554
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97109493
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95127897
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94540563
102* SOX17_20123909_ChIP-Seq_XEN_Mouse0.94155589
103ELF5_23300383_ChIP-Seq_T47D_Human0.94143677
104* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94120749
105MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93937967
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.92741123
107KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91939762
108MYB_26560356_Chip-Seq_TH2_Human0.91695003
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91373181
110CHD1_26751641_Chip-Seq_LNCaP_Human0.90713026
111HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90521390
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89595739
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89573719
114CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89400372
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89198620
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89078346
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85888274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.32439812
2MP0002877_abnormal_melanocyte_morpholog3.08181769
3MP0004264_abnormal_extraembryonic_tissu2.97965502
4MP0005220_abnormal_exocrine_pancreas2.92494358
5MP0003183_abnormal_peptide_metabolism2.88886379
6MP0008260_abnormal_autophagy2.85104027
7MP0002139_abnormal_hepatobiliary_system2.78816204
8MP0003195_calcinosis2.78637306
9MP0001666_abnormal_nutrient_absorption2.67700583
10MP0004043_abnormal_pH_regulation2.65478955
11MP0003693_abnormal_embryo_hatching2.64386218
12MP0002693_abnormal_pancreas_physiology2.56883281
13MP0005365_abnormal_bile_salt2.54051864
14MP0001944_abnormal_pancreas_morphology2.30253116
15MP0005083_abnormal_biliary_tract2.19173256
16MP0005451_abnormal_body_composition2.15360874
17MP0006054_spinal_hemorrhage2.04424385
18MP0003283_abnormal_digestive_organ1.97516554
19MP0003300_gastrointestinal_ulcer1.95674499
20MP0008057_abnormal_DNA_replication1.94474590
21MP0005360_urolithiasis1.91792724
22MP0004957_abnormal_blastocyst_morpholog1.91231963
23MP0000678_abnormal_parathyroid_gland1.86691624
24MP0002138_abnormal_hepatobiliary_system1.83547042
25MP0005085_abnormal_gallbladder_physiolo1.82569141
26MP0009643_abnormal_urine_homeostasis1.81656483
27MP0003941_abnormal_skin_development1.80947685
28MP0003786_premature_aging1.79217115
29MP0003718_maternal_effect1.78632569
30MP0010352_gastrointestinal_tract_polyps1.72551824
31MP0000013_abnormal_adipose_tissue1.71487904
32MP0005058_abnormal_lysosome_morphology1.70626406
33MP0002796_impaired_skin_barrier1.68873626
34MP0002163_abnormal_gland_morphology1.59755888
35MP0006035_abnormal_mitochondrial_morpho1.55016773
36MP0003186_abnormal_redox_activity1.54567377
37MP0003252_abnormal_bile_duct1.51609080
38MP0005501_abnormal_skin_physiology1.50570292
39MP0009780_abnormal_chondrocyte_physiolo1.48047702
40MP0009840_abnormal_foam_cell1.47891408
41MP0001216_abnormal_epidermal_layer1.47013591
42MP0003868_abnormal_feces_composition1.45849534
43MP0010678_abnormal_skin_adnexa1.36806024
44MP0001727_abnormal_embryo_implantation1.34334512
45MP0005408_hypopigmentation1.33339695
46MP0002078_abnormal_glucose_homeostasis1.30932433
47MP0010234_abnormal_vibrissa_follicle1.30851786
48MP0003077_abnormal_cell_cycle1.29379404
49MP0005380_embryogenesis_phenotype1.28175677
50MP0001672_abnormal_embryogenesis/_devel1.28175677
51MP0001756_abnormal_urination1.27813498
52MP0008875_abnormal_xenobiotic_pharmacok1.24003980
53MP0005379_endocrine/exocrine_gland_phen1.22990178
54MP0002090_abnormal_vision1.22333666
55MP0003221_abnormal_cardiomyocyte_apopto1.22276611
56MP0002928_abnormal_bile_duct1.22186284
57MP0000627_abnormal_mammary_gland1.22050636
58MP0005384_cellular_phenotype1.21288695
59MP0002909_abnormal_adrenal_gland1.20986390
60MP0005332_abnormal_amino_acid1.20420184
61MP0005636_abnormal_mineral_homeostasis1.19597174
62MP0000313_abnormal_cell_death1.19539743
63MP0003436_decreased_susceptibility_to1.19233061
64MP0001915_intracranial_hemorrhage1.16536734
65MP0003453_abnormal_keratinocyte_physiol1.16052771
66MP0003315_abnormal_perineum_morphology1.15476422
67MP0003866_abnormal_defecation1.13187133
68MP0001764_abnormal_homeostasis1.12515158
69MP0003984_embryonic_growth_retardation1.12513794
70MP0005084_abnormal_gallbladder_morpholo1.12160001
71MP0002098_abnormal_vibrissa_morphology1.12055402
72MP0010307_abnormal_tumor_latency1.12041397
73MP0004233_abnormal_muscle_weight1.10833770
74MP0003111_abnormal_nucleus_morphology1.07774993
75MP0009697_abnormal_copulation1.06861577
76MP0002088_abnormal_embryonic_growth/wei1.06510021
77MP0001346_abnormal_lacrimal_gland1.05980600
78MP0005621_abnormal_cell_physiology1.05203024
79MP0000609_abnormal_liver_physiology1.04426838
80MP0010094_abnormal_chromosome_stability1.03219293
81MP0000613_abnormal_salivary_gland1.02831851
82MP0003656_abnormal_erythrocyte_physiolo1.02436622
83MP0001765_abnormal_ion_homeostasis1.02271331
84MP0001529_abnormal_vocalization1.02150118
85MP0001881_abnormal_mammary_gland1.01166575
86MP0010386_abnormal_urinary_bladder1.00983568
87MP0002086_abnormal_extraembryonic_tissu0.99909503
88MP0001661_extended_life_span0.97791924
89MP0004782_abnormal_surfactant_physiolog0.97539157
90MP0001730_embryonic_growth_arrest0.97365669
91MP0000490_abnormal_crypts_of0.97292976
92MP0001853_heart_inflammation0.96397447
93MP0005310_abnormal_salivary_gland0.93743536
94MP0008007_abnormal_cellular_replicative0.92151579
95MP0008932_abnormal_embryonic_tissue0.91990471
96MP0000598_abnormal_liver_morphology0.91556094
97MP0000003_abnormal_adipose_tissue0.91228023
98MP0003172_abnormal_lysosome_physiology0.91061796
99MP0000377_abnormal_hair_follicle0.90543298
100MP0001845_abnormal_inflammatory_respons0.90247777
101MP0006082_CNS_inflammation0.89697667
102MP0005076_abnormal_cell_differentiation0.89390833
103MP0002006_tumorigenesis0.88494190
104MP0000647_abnormal_sebaceous_gland0.88476551
105MP0008058_abnormal_DNA_repair0.87422985
106MP0004019_abnormal_vitamin_homeostasis0.86967384
107MP0000462_abnormal_digestive_system0.86274892
108MP0003890_abnormal_embryonic-extraembry0.84831446
109MP0002084_abnormal_developmental_patter0.82923507
110MP0002166_altered_tumor_susceptibility0.82111282
111MP0005319_abnormal_enzyme/_coenzyme0.81980678
112MP0002896_abnormal_bone_mineralization0.81709681
113MP0010155_abnormal_intestine_physiology0.80902190
114MP0002060_abnormal_skin_morphology0.80640795
115MP0000579_abnormal_nail_morphology0.80417069
116MP0000858_altered_metastatic_potential0.80302600
117MP0006036_abnormal_mitochondrial_physio0.79995625
118MP0003705_abnormal_hypodermis_morpholog0.79614427
119MP0003763_abnormal_thymus_physiology0.79268948
120MP0008469_abnormal_protein_level0.77519554
121MP0003959_abnormal_lean_body0.77186419
122MP0001533_abnormal_skeleton_physiology0.75692648
123MP0003566_abnormal_cell_adhesion0.75264670
124MP0002085_abnormal_embryonic_tissue0.75090207
125MP0009333_abnormal_splenocyte_physiolog0.74584146
126MP0000350_abnormal_cell_proliferation0.74427167
127MP0010329_abnormal_lipoprotein_level0.74009067
128MP0003953_abnormal_hormone_level0.73909989
129MP0000358_abnormal_cell_content/0.73769875
130MP0000685_abnormal_immune_system0.71994285
131MP0003795_abnormal_bone_structure0.71890405
132MP0005395_other_phenotype0.71673732
133MP0005394_taste/olfaction_phenotype0.70290693
134MP0005499_abnormal_olfactory_system0.70290693
135MP0002136_abnormal_kidney_physiology0.70096946
136MP0003943_abnormal_hepatobiliary_system0.69839056
137MP0002118_abnormal_lipid_homeostasis0.69595796
138MP0000477_abnormal_intestine_morphology0.69048217
139MP0000604_amyloidosis0.68955915
140MP0009672_abnormal_birth_weight0.68622617
141MP0002080_prenatal_lethality0.68576613
142MP0002876_abnormal_thyroid_physiology0.68484022
143MP0004197_abnormal_fetal_growth/weight/0.68079544
144MP0004947_skin_inflammation0.67135829
145MP0009642_abnormal_blood_homeostasis0.66357065
146MP0002019_abnormal_tumor_incidence0.66280442
147MP0005000_abnormal_immune_tolerance0.64721295
148MP0009785_altered_susceptibility_to0.63063557
149MP0003191_abnormal_cellular_cholesterol0.63051276
150MP0001697_abnormal_embryo_size0.62656412

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.59097397
2Hypoglycemic seizures (HP:0002173)4.42962547
3Hypoglycemic coma (HP:0001325)4.32171980
4Symptomatic seizures (HP:0011145)4.08554222
5Abnormality of glycolysis (HP:0004366)3.92406272
6Abnormality of endocrine pancreas physiology (HP:0012093)3.88531893
7Abnormality of the pancreatic islet cells (HP:0006476)3.88531893
8Microvesicular hepatic steatosis (HP:0001414)3.78722499
9Abnormality of the intrinsic pathway (HP:0010989)3.71152681
10Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.58752648
11Increased serum pyruvate (HP:0003542)3.51683172
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.45301697
13Ketoacidosis (HP:0001993)3.34327111
14Generalized aminoaciduria (HP:0002909)3.32692866
15Late onset (HP:0003584)3.27751328
16Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.25127655
17Abnormal protein N-linked glycosylation (HP:0012347)3.25127655
18Abnormal protein glycosylation (HP:0012346)3.25127655
19Abnormal glycosylation (HP:0012345)3.25127655
20Pancreatic islet-cell hyperplasia (HP:0004510)3.17525441
21Type I transferrin isoform profile (HP:0003642)3.15747438
22Abnormality of monocarboxylic acid metabolism (HP:0010996)3.15027388
23Cholecystitis (HP:0001082)3.09016864
24Abnormal gallbladder physiology (HP:0012438)3.09016864
25Gout (HP:0001997)3.06737292
26Vacuolated lymphocytes (HP:0001922)3.03574012
27Hyperglycemia (HP:0003074)2.89544917
28Abnormal pancreas size (HP:0012094)2.83102247
29Abnormality of the common coagulation pathway (HP:0010990)2.80880802
30Cortical dysplasia (HP:0002539)2.70973989
31Dysostosis multiplex (HP:0000943)2.69890715
32Loss of speech (HP:0002371)2.66533420
33Intrahepatic cholestasis (HP:0001406)2.63188520
34Hypokinesia (HP:0002375)2.58651028
35Conjugated hyperbilirubinemia (HP:0002908)2.58049053
36Mucopolysacchariduria (HP:0008155)2.56818164
37Urinary glycosaminoglycan excretion (HP:0003541)2.56818164
38Reduced antithrombin III activity (HP:0001976)2.55379241
39Abnormality of the anterior horn cell (HP:0006802)2.49348981
40Degeneration of anterior horn cells (HP:0002398)2.49348981
41Fat malabsorption (HP:0002630)2.43762939
42Prominent metopic ridge (HP:0005487)2.43124637
43Ketosis (HP:0001946)2.39195438
44Abnormality of T cell physiology (HP:0011840)2.34165243
45Thoracolumbar scoliosis (HP:0002944)2.33728197
46Multiple enchondromatosis (HP:0005701)2.33367099
47Insulin-resistant diabetes mellitus (HP:0000831)2.31991415
48Abnormality of calcium-phosphate metabolism (HP:0100530)2.30644448
49Abnormality of purine metabolism (HP:0004352)2.29676934
50Exocrine pancreatic insufficiency (HP:0001738)2.29124318
51Limb hypertonia (HP:0002509)2.27827977
52Upper limb muscle weakness (HP:0003484)2.27316803
53Insulin resistance (HP:0000855)2.26076367
54Septate vagina (HP:0001153)2.25996418
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.23130931
56Large for gestational age (HP:0001520)2.21430950
57Abnormality of alkaline phosphatase activity (HP:0004379)2.21216226
5811 pairs of ribs (HP:0000878)2.20631354
59Megaloblastic anemia (HP:0001889)2.20568366
60Abnormality of nucleobase metabolism (HP:0010932)2.20434731
61Micronodular cirrhosis (HP:0001413)2.19819334
62Death in infancy (HP:0001522)2.19318466
63Secondary amenorrhea (HP:0000869)2.18898786
64Overlapping toe (HP:0001845)2.18449227
65Abnormal enzyme/coenzyme activity (HP:0012379)2.17450996
66Sparse eyelashes (HP:0000653)2.16375703
67Orthostatic hypotension (HP:0001278)2.15408990
68Spastic diplegia (HP:0001264)2.15358003
69Abnormal foot bone ossification (HP:0010675)2.15242486
70Metaphyseal cupping (HP:0003021)2.14770575
71Tetraparesis (HP:0002273)2.14615602
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14481783
73Abnormality of polysaccharide metabolism (HP:0011012)2.14481783
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14481783
75Postnatal microcephaly (HP:0005484)2.13609017
76Entropion (HP:0000621)2.12306516
77Rough bone trabeculation (HP:0100670)2.11910804
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.11349893
79Progressive external ophthalmoplegia (HP:0000590)2.08264252
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.07245662
81Abnormality of glycolipid metabolism (HP:0010969)2.07245662
82Abnormality of liposaccharide metabolism (HP:0010968)2.07245662
83Oral leukoplakia (HP:0002745)2.07236294
84Cutaneous melanoma (HP:0012056)2.07183482
85Abnormal biliary tract morphology (HP:0012440)2.06539558
86Thrombocytosis (HP:0001894)2.06386680
87Chromsome breakage (HP:0040012)2.06263651
88Increased serum lactate (HP:0002151)2.06253150
89Aplastic anemia (HP:0001915)2.05350450
90Abnormal trabecular bone morphology (HP:0100671)2.04170792
91Hyperactive renin-angiotensin system (HP:0000841)2.04121736
92Abdominal distention (HP:0003270)2.03690046
93Hypokalemia (HP:0002900)2.02157697
94Abnormality of pyrimidine metabolism (HP:0004353)2.01950324
95Irregular vertebral endplates (HP:0003301)2.01533206
96Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00923790
97Elevated alkaline phosphatase (HP:0003155)1.99386157
98Hepatic necrosis (HP:0002605)1.97143994
99Ependymoma (HP:0002888)1.95180969
100CNS hypomyelination (HP:0003429)1.94426678
101Deviation of the thumb (HP:0009603)1.93247495
102Steatorrhea (HP:0002570)1.92671328
103Autoimmune hemolytic anemia (HP:0001890)1.92164700
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89445445
105Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89445445
106Fasciculations (HP:0002380)1.89349135
107Abnormality of the distal phalanges of the toes (HP:0010182)1.89198064
108Decreased circulating renin level (HP:0003351)1.88581176
109Abnormality of urine glucose concentration (HP:0011016)1.87683498
110Glycosuria (HP:0003076)1.87683498
111Hyperammonemia (HP:0001987)1.86516254
112Abnormality of the metopic suture (HP:0005556)1.85313727
113Missing ribs (HP:0000921)1.84926526
114Lipid accumulation in hepatocytes (HP:0006561)1.84378268
115Dysautonomia (HP:0002459)1.84111208
116Increased hepatocellular lipid droplets (HP:0006565)1.83946125
117Atrophy/Degeneration involving motor neurons (HP:0007373)1.83646636
118Epiphyseal stippling (HP:0010655)1.83329718
119Villous atrophy (HP:0011473)1.83328686
120Abnormality of small intestinal villus morphology (HP:0011472)1.83328686
121Increased IgM level (HP:0003496)1.82217678
122Proximal placement of thumb (HP:0009623)1.81421629
123Lower limb hyperreflexia (HP:0002395)1.81396709
124Agnosia (HP:0010524)1.81308354
125Abnormality of methionine metabolism (HP:0010901)1.81147026
126Abnormality of the preputium (HP:0100587)1.80683172
127Proximal tubulopathy (HP:0000114)1.80566263
128Progressive neurologic deterioration (HP:0002344)1.79674399
129Aplasia/hypoplasia of the uterus (HP:0008684)1.79144812
130Abnormality of T cells (HP:0002843)1.78404506
131Progressive hearing impairment (HP:0001730)1.78291542
132Hyperparathyroidism (HP:0000843)1.78120513
133Hypoplasia of the pons (HP:0012110)1.77416304
134Neoplasm of the adrenal gland (HP:0100631)1.77185460
135Irritability (HP:0000737)1.76714861
136Unilateral renal agenesis (HP:0000122)1.76193576
137Abnormality of fatty-acid metabolism (HP:0004359)1.76066971
138Glucose intolerance (HP:0000833)1.74931124
139Renal salt wasting (HP:0000127)1.74817945
140Squamous cell carcinoma (HP:0002860)1.72999445
141Increased CSF lactate (HP:0002490)1.72200108
142IgM deficiency (HP:0002850)1.72137894
143Premature ovarian failure (HP:0008209)1.71840881
144Osteomalacia (HP:0002749)1.71655790
145Hypophosphatemia (HP:0002148)1.70367826
146Abnormality of chloride homeostasis (HP:0011422)1.69960489
147Congenital ichthyosiform erythroderma (HP:0007431)1.69957853
148Protuberant abdomen (HP:0001538)1.69791531
149Papillary thyroid carcinoma (HP:0002895)1.69227072
150Hyperphosphaturia (HP:0003109)1.68905693
151Poikiloderma (HP:0001029)1.68337024
152Acute hepatic failure (HP:0006554)1.68330836
153Hypobetalipoproteinemia (HP:0003563)1.68071130
154Hepatocellular necrosis (HP:0001404)1.67665055
155Poor head control (HP:0002421)1.67404771
156Nausea (HP:0002018)1.67043504
157Beaking of vertebral bodies (HP:0004568)1.66608213
158Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66510203
159Opisthotonus (HP:0002179)1.66460708
160Abnormalities of placenta or umbilical cord (HP:0001194)1.65561960
161Abnormal epiphyseal ossification (HP:0010656)1.65293926
162Abnormal tarsal ossification (HP:0008369)1.65089148
163Spastic paraparesis (HP:0002313)1.64906903
164Lactic acidosis (HP:0003128)1.64693367
165Chronic bronchitis (HP:0004469)1.64318287
166Ragged-red muscle fibers (HP:0003200)1.63888976
167Prolonged neonatal jaundice (HP:0006579)1.62810638
168Onycholysis (HP:0001806)1.62722796
169Abnormal mitochondria in muscle tissue (HP:0008316)1.62635292
170Abnormal neuron morphology (HP:0012757)1.61367729
171Abnormality of the motor neurons (HP:0002450)1.61367729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.46698245
2ERN13.54978440
3EIF2AK33.31189458
4BUB13.20111358
5BCR2.89416493
6BCKDK2.83349173
7TRIM282.55355036
8BRSK22.45891032
9SMG12.37432501
10SCYL22.35464546
11FLT32.35160978
12INSRR2.25498377
13TAOK32.24728970
14MST42.20841209
15TSSK62.18094934
16EIF2AK12.13036779
17FRK2.09857063
18VRK22.06821619
19TESK22.00684220
20IRAK31.98891378
21MST1R1.93774519
22EPHA21.86586660
23ACVR1B1.84786396
24MAPK151.78408182
25TESK11.77995232
26WEE11.70027521
27TAF11.59252478
28STK161.58080281
29CDC71.55015547
30PDK21.51114053
31MAP3K121.47515725
32ZAP701.39137009
33MAP3K31.35362038
34AKT31.33947654
35RPS6KB21.29596693
36HIPK21.28832678
37SIK31.27401751
38MET1.23888993
39ARAF1.23823857
40MAP3K21.20494240
41WNK31.18964100
42ERBB41.14403094
43PIM21.12057048
44ERBB31.11750346
45PTK61.08462486
46JAK31.07650017
47STK101.05173975
48CSNK1G31.05123772
49IRAK11.04866469
50ITK1.01354584
51CSNK1A1L1.00123450
52BRSK10.99834744
53PIK3CG0.99493016
54RPS6KA40.96852484
55CDK90.95502404
56IRAK40.95489910
57WNK40.94698000
58FER0.93956832
59KSR10.92675543
60DAPK10.91452684
61RIPK10.89291956
62MAP3K80.87777042
63MAP3K140.87692718
64LMTK20.87585186
65TEC0.87294688
66PTK20.82531375
67MAPKAPK50.81957465
68STK38L0.81151305
69ALK0.80565168
70ZAK0.78964791
71FGFR40.78746340
72NME10.78656106
73EIF2AK20.77821257
74NME20.76700126
75NEK10.76105298
76LIMK10.75101844
77CSNK1G10.74142710
78PAK40.73346313
79ATR0.72789051
80PRKCI0.72545848
81BTK0.71883516
82TTK0.70235898
83AURKB0.69593618
84VRK10.68611225
85NEK90.67483196
86TYK20.66356369
87CDK60.65329643
88ICK0.64353303
89NEK60.63595295
90PLK30.62729872
91MAP2K30.62390372
92MAP2K20.62230867
93MAPKAPK30.60713868
94PLK10.60375923
95CHEK20.60283703
96PLK40.58519924
97CSNK1G20.57844593
98MAP4K10.57334189
99CLK10.57211234
100LRRK20.56212507
101STK40.55898064
102STK30.55814760
103ATM0.55811264
104FGR0.55666073
105EPHB10.55255761
106EPHA30.53790697
107CDK120.53448743
108TBK10.52990584
109CSK0.51625436
110SRPK10.51118870
111CHUK0.50383521
112CDK80.50324261
113SIK10.48496423
114MAP3K50.47388414
115TGFBR10.47233150
116LATS10.47012223
117PBK0.46121205
118TLK10.45537612
119JAK20.44041767
120CAMKK20.43860433
121CHEK10.42846290
122MAP3K110.42619637
123AURKA0.42097003
124NEK20.42033443
125MKNK10.41838770
126EEF2K0.41759989
127DYRK30.40949312
128MAP3K10.39902565
129CSNK2A20.39516092
130CDK70.37466907
131BRAF0.37301157
132CSNK2A10.36919514
133NLK0.36836801
134CDK40.36069735
135CDK140.36040247
136JAK10.35950349
137PDGFRA0.35542550
138NUAK10.34882154
139CCNB10.34864902
140DYRK1B0.34323490
141CDK180.33024963
142AKT20.32246485
143CAMK1D0.31243553
144RAF10.26832654
145MAPKAPK20.26090654

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.76203412
2Protein export_Homo sapiens_hsa030605.19419052
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.22823697
4Sulfur metabolism_Homo sapiens_hsa009203.05495548
5Fatty acid elongation_Homo sapiens_hsa000622.72578654
6Selenocompound metabolism_Homo sapiens_hsa004502.45665298
7Folate biosynthesis_Homo sapiens_hsa007902.40932703
8One carbon pool by folate_Homo sapiens_hsa006702.23013772
9DNA replication_Homo sapiens_hsa030302.11204186
10N-Glycan biosynthesis_Homo sapiens_hsa005102.05903291
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03224555
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.84853213
13Mismatch repair_Homo sapiens_hsa034301.82223210
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79815988
15Vitamin B6 metabolism_Homo sapiens_hsa007501.73805758
16Proteasome_Homo sapiens_hsa030501.65867248
17Vibrio cholerae infection_Homo sapiens_hsa051101.55103410
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.53789733
19Fatty acid metabolism_Homo sapiens_hsa012121.42767196
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42036237
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39026371
22Other glycan degradation_Homo sapiens_hsa005111.36220240
23Antigen processing and presentation_Homo sapiens_hsa046121.31912990
24Fat digestion and absorption_Homo sapiens_hsa049751.27741403
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26461832
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26379598
27Galactose metabolism_Homo sapiens_hsa000521.25753584
28Lysosome_Homo sapiens_hsa041421.22157270
29Legionellosis_Homo sapiens_hsa051341.21280135
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19818137
31Base excision repair_Homo sapiens_hsa034101.15585928
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14003158
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12979090
34Pyrimidine metabolism_Homo sapiens_hsa002401.09798749
35Type I diabetes mellitus_Homo sapiens_hsa049401.09557136
36Tryptophan metabolism_Homo sapiens_hsa003801.07755604
37RNA transport_Homo sapiens_hsa030131.03836705
38Glutathione metabolism_Homo sapiens_hsa004801.02249457
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01924515
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.99223465
41mRNA surveillance pathway_Homo sapiens_hsa030150.97844292
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94061314
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92804511
44Nucleotide excision repair_Homo sapiens_hsa034200.91347657
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90986063
46Starch and sucrose metabolism_Homo sapiens_hsa005000.90958591
47RNA polymerase_Homo sapiens_hsa030200.90811554
48Spliceosome_Homo sapiens_hsa030400.89716786
49Histidine metabolism_Homo sapiens_hsa003400.89098672
50Biosynthesis of amino acids_Homo sapiens_hsa012300.87044037
51Fructose and mannose metabolism_Homo sapiens_hsa000510.84903466
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.84825890
53Non-homologous end-joining_Homo sapiens_hsa034500.84242520
54Homologous recombination_Homo sapiens_hsa034400.83433181
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82400318
56Fatty acid biosynthesis_Homo sapiens_hsa000610.81818383
57Peroxisome_Homo sapiens_hsa041460.81696021
58Fanconi anemia pathway_Homo sapiens_hsa034600.78994720
59Cell cycle_Homo sapiens_hsa041100.76971449
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.74217062
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71381285
62Pentose phosphate pathway_Homo sapiens_hsa000300.71187631
63Renin-angiotensin system_Homo sapiens_hsa046140.71131050
64Shigellosis_Homo sapiens_hsa051310.70411092
65Butanoate metabolism_Homo sapiens_hsa006500.69607553
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.69348337
67Vitamin digestion and absorption_Homo sapiens_hsa049770.68745403
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68578976
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.68466403
70Arginine and proline metabolism_Homo sapiens_hsa003300.68098734
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66897221
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66277100
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65133463
74Pyruvate metabolism_Homo sapiens_hsa006200.63391432
75Carbon metabolism_Homo sapiens_hsa012000.63149712
76Oxidative phosphorylation_Homo sapiens_hsa001900.61944078
77Collecting duct acid secretion_Homo sapiens_hsa049660.61466220
78Sulfur relay system_Homo sapiens_hsa041220.61438462
79Pancreatic secretion_Homo sapiens_hsa049720.60694995
80Steroid biosynthesis_Homo sapiens_hsa001000.59256034
81Fatty acid degradation_Homo sapiens_hsa000710.57794381
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57607891
83p53 signaling pathway_Homo sapiens_hsa041150.57040851
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55820978
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55226720
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54750989
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54403836
88Viral carcinogenesis_Homo sapiens_hsa052030.54201596
89Epstein-Barr virus infection_Homo sapiens_hsa051690.52969948
90Sphingolipid metabolism_Homo sapiens_hsa006000.52756651
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52295407
92Protein digestion and absorption_Homo sapiens_hsa049740.50574749
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49419204
94Phenylalanine metabolism_Homo sapiens_hsa003600.49241984
95Chemical carcinogenesis_Homo sapiens_hsa052040.48188725
96Apoptosis_Homo sapiens_hsa042100.45712698
97Metabolic pathways_Homo sapiens_hsa011000.44437431
98Huntingtons disease_Homo sapiens_hsa050160.43527145
99Parkinsons disease_Homo sapiens_hsa050120.43399838
100Caffeine metabolism_Homo sapiens_hsa002320.43001165
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42910300
102Purine metabolism_Homo sapiens_hsa002300.40730721
103Salmonella infection_Homo sapiens_hsa051320.39866775
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.39722766
105Oocyte meiosis_Homo sapiens_hsa041140.39512070
106Thyroid cancer_Homo sapiens_hsa052160.39318624
107ABC transporters_Homo sapiens_hsa020100.39298026
108Phagosome_Homo sapiens_hsa041450.39028850
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36874567
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.35243719
111Thyroid hormone synthesis_Homo sapiens_hsa049180.34877765
112Measles_Homo sapiens_hsa051620.34855559
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34154686
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32854767
115Influenza A_Homo sapiens_hsa051640.31835614
116Systemic lupus erythematosus_Homo sapiens_hsa053220.31508384
117beta-Alanine metabolism_Homo sapiens_hsa004100.30616889
118Herpes simplex infection_Homo sapiens_hsa051680.29410436
119Bladder cancer_Homo sapiens_hsa052190.29327617
120Glycerolipid metabolism_Homo sapiens_hsa005610.28911617
121Regulation of autophagy_Homo sapiens_hsa041400.28820654
122RNA degradation_Homo sapiens_hsa030180.28381419
123Propanoate metabolism_Homo sapiens_hsa006400.26707418
124Tyrosine metabolism_Homo sapiens_hsa003500.26118307
125Basal transcription factors_Homo sapiens_hsa030220.24552974
126Adherens junction_Homo sapiens_hsa045200.23320207
127Hepatitis B_Homo sapiens_hsa051610.22557318
128Pancreatic cancer_Homo sapiens_hsa052120.20239665

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