SEC23IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.45102909
2nuclear pore complex assembly (GO:0051292)4.28645518
3* acrosome assembly (GO:0001675)4.25140579
4cilium or flagellum-dependent cell motility (GO:0001539)4.25002804
5sperm-egg recognition (GO:0035036)4.09246815
6ribosome assembly (GO:0042255)4.05472385
7multicellular organism reproduction (GO:0032504)3.98013963
8nuclear pore organization (GO:0006999)3.93976416
9fusion of sperm to egg plasma membrane (GO:0007342)3.89935764
10COPII vesicle coating (GO:0048208)3.87742396
11male meiosis (GO:0007140)3.80938017
12binding of sperm to zona pellucida (GO:0007339)3.77013797
13cell-cell recognition (GO:0009988)3.71295213
14establishment of integrated proviral latency (GO:0075713)3.68214995
15regulation of sister chromatid cohesion (GO:0007063)3.67842863
16DNA methylation involved in gamete generation (GO:0043046)3.65447839
17UDP-N-acetylglucosamine metabolic process (GO:0006047)3.65228103
18somatic diversification of immune receptors via somatic mutation (GO:0002566)3.59925637
19double-strand break repair via nonhomologous end joining (GO:0006303)3.57753186
20non-recombinational repair (GO:0000726)3.57753186
21Golgi transport vesicle coating (GO:0048200)3.52870538
22COPI coating of Golgi vesicle (GO:0048205)3.52870538
23rRNA methylation (GO:0031167)3.47497333
24pore complex assembly (GO:0046931)3.47206698
25synaptonemal complex organization (GO:0070193)3.39931752
26sister chromatid segregation (GO:0000819)3.39607029
27axonemal dynein complex assembly (GO:0070286)3.39319553
28synaptonemal complex assembly (GO:0007130)3.33911960
29sperm motility (GO:0030317)3.32977692
30cell wall macromolecule catabolic process (GO:0016998)3.30129767
31cell wall macromolecule metabolic process (GO:0044036)3.30129767
32mitotic sister chromatid segregation (GO:0000070)3.27056418
33negative regulation of keratinocyte proliferation (GO:0010839)3.19296008
34histone-serine phosphorylation (GO:0035404)3.15041182
35mitotic spindle checkpoint (GO:0071174)3.12153688
36DNA strand elongation involved in DNA replication (GO:0006271)3.10849390
37chromosome organization involved in meiosis (GO:0070192)3.09387768
38protein K6-linked ubiquitination (GO:0085020)3.08886943
39transcription from mitochondrial promoter (GO:0006390)3.08701997
40regulation of RNA export from nucleus (GO:0046831)3.06695274
41response to X-ray (GO:0010165)3.05268863
42DNA geometric change (GO:0032392)3.05009497
43negative regulation of chromosome segregation (GO:0051985)3.03776672
44regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02936952
45regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02936952
46monoubiquitinated protein deubiquitination (GO:0035520)3.02836534
47DNA strand elongation (GO:0022616)3.02806768
48rRNA modification (GO:0000154)3.02773366
49negative regulation of DNA repair (GO:0045738)3.02016777
50spermatid development (GO:0007286)3.01241033
51reproduction (GO:0000003)3.00437128
52motile cilium assembly (GO:0044458)3.00130255
53DNA unwinding involved in DNA replication (GO:0006268)2.99894499
54DNA duplex unwinding (GO:0032508)2.99380484
55negative regulation of mitotic sister chromatid separation (GO:2000816)2.97991108
56negative regulation of sister chromatid segregation (GO:0033046)2.97991108
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97991108
58negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97991108
59negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97991108
60regulation of centrosome cycle (GO:0046605)2.96865458
61positive regulation of cell cycle checkpoint (GO:1901978)2.95417057
62mitotic chromosome condensation (GO:0007076)2.93191747
63regulation of chromosome segregation (GO:0051983)2.92741986
64establishment of viral latency (GO:0019043)2.92507704
65positive regulation of chromosome segregation (GO:0051984)2.92185390
66regulation of sister chromatid segregation (GO:0033045)2.89964260
67regulation of mitotic sister chromatid separation (GO:0010965)2.89964260
68regulation of mitotic sister chromatid segregation (GO:0033047)2.89964260
69folic acid-containing compound biosynthetic process (GO:0009396)2.88635212
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88625047
71signal peptide processing (GO:0006465)2.87950094
72mitotic spindle assembly checkpoint (GO:0007094)2.87504530
73spindle assembly checkpoint (GO:0071173)2.86082592
74regulation of centrosome duplication (GO:0010824)2.85878499
75regulation of DNA endoreduplication (GO:0032875)2.83636685
76peptidyl-lysine dimethylation (GO:0018027)2.81936191
77prenylation (GO:0097354)2.81725433
78protein prenylation (GO:0018342)2.81725433
79meiotic chromosome segregation (GO:0045132)2.81014685
80maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.76854858
81nucleobase biosynthetic process (GO:0046112)2.76847281
82IMP biosynthetic process (GO:0006188)2.76043833
83histone exchange (GO:0043486)2.74525013
84heterochromatin organization (GO:0070828)2.73844421
85mitochondrial RNA metabolic process (GO:0000959)2.73091511
86nuclear envelope organization (GO:0006998)2.71973174
87regulation of nucleobase-containing compound transport (GO:0032239)2.71946625
88chromatin remodeling at centromere (GO:0031055)2.71514391
89attachment of spindle microtubules to kinetochore (GO:0008608)2.70147010
90pre-miRNA processing (GO:0031054)2.69969518
91regulation of meiosis I (GO:0060631)2.69442087
92purine nucleobase biosynthetic process (GO:0009113)2.69379242
93positive regulation of cell size (GO:0045793)2.69368274
94kinetochore organization (GO:0051383)2.69115629
95centriole assembly (GO:0098534)2.68880723
96CENP-A containing nucleosome assembly (GO:0034080)2.67274997
97meiotic nuclear division (GO:0007126)2.64109803
98microtubule depolymerization (GO:0007019)2.63185358
99somatic recombination of immunoglobulin gene segments (GO:0016447)2.62840002
100IMP metabolic process (GO:0046040)2.61988563
101cytoplasmic mRNA processing body assembly (GO:0033962)2.61678955
102plasma membrane fusion (GO:0045026)2.61573820
103intraciliary transport (GO:0042073)2.61531617
104regulation of centriole replication (GO:0046599)2.61527433
105sister chromatid cohesion (GO:0007062)2.60567126
106RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58943596
107nucleotide-excision repair, DNA gap filling (GO:0006297)2.57599078
108nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.57568340
109interkinetic nuclear migration (GO:0022027)2.56272532
110protein localization to chromosome, centromeric region (GO:0071459)2.54684003
111gene silencing by RNA (GO:0031047)2.53333063
112synapsis (GO:0007129)2.52691260
113mitotic sister chromatid cohesion (GO:0007064)2.52072188
114replicative senescence (GO:0090399)2.51680225
115mitotic nuclear envelope disassembly (GO:0007077)2.48119525
116establishment of chromosome localization (GO:0051303)2.48005883
117protein localization to kinetochore (GO:0034501)2.46062057
118mitotic metaphase plate congression (GO:0007080)2.45344637
119zinc ion transmembrane transport (GO:0071577)2.44933213
120epithelial cilium movement (GO:0003351)2.43831350
121metaphase plate congression (GO:0051310)2.43004671
122ER overload response (GO:0006983)2.41412066
123telomere maintenance via recombination (GO:0000722)2.41119320
124maturation of 5.8S rRNA (GO:0000460)2.40888203
125centriole replication (GO:0007099)2.39400147
126deoxyribonucleotide biosynthetic process (GO:0009263)2.39166658
127positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.37717801
128positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.37717801
129positive regulation of mitotic sister chromatid separation (GO:1901970)2.37717801
130negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.37162475
131regulation of male gonad development (GO:2000018)2.37130468
132regulation of double-strand break repair via homologous recombination (GO:0010569)2.37035610
133male meiosis I (GO:0007141)2.36196409
134regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.35931806
135DNA replication-independent nucleosome assembly (GO:0006336)2.35772688
136DNA replication-independent nucleosome organization (GO:0034724)2.35772688
137negative regulation of glycogen biosynthetic process (GO:0045719)2.35530979
138negative regulation of DNA-dependent DNA replication (GO:2000104)2.34869742
139meiotic cell cycle (GO:0051321)2.34351968
140DNA replication checkpoint (GO:0000076)2.33164206
141ATP-dependent chromatin remodeling (GO:0043044)2.31857228
142sequestering of metal ion (GO:0051238)2.31649396
143DNA replication initiation (GO:0006270)2.31576267
144* single fertilization (GO:0007338)2.30800850
145regulation of mitotic spindle checkpoint (GO:1903504)2.27914167
146regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.27914167
147kinetochore assembly (GO:0051382)2.26863532
148protein retention in ER lumen (GO:0006621)2.26614265
149telomere maintenance via semi-conservative replication (GO:0032201)2.24373300
150cilium movement (GO:0003341)2.24260162
151mitotic recombination (GO:0006312)2.24208631
152positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.24125762
153DNA replication-dependent nucleosome assembly (GO:0006335)2.23663572
154DNA replication-dependent nucleosome organization (GO:0034723)2.23663572
155nuclear envelope disassembly (GO:0051081)2.22906252
156membrane disassembly (GO:0030397)2.22906252
157DNA ligation (GO:0006266)2.22162644
158germ cell development (GO:0007281)2.20491660
159histone H3-K9 methylation (GO:0051567)2.19825070
160spindle checkpoint (GO:0031577)2.19221512
161DNA synthesis involved in DNA repair (GO:0000731)2.18551767
162meiotic cell cycle process (GO:1903046)2.18280075
163cellular response to gamma radiation (GO:0071480)2.16061679
164somatic hypermutation of immunoglobulin genes (GO:0016446)2.15459251

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.89566968
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.70063023
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11653727
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.90874528
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59291520
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.57058850
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53211473
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50808902
9* ELK1_19687146_ChIP-ChIP_HELA_Human2.49237473
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44314458
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.42257114
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.28000545
13DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.24475958
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.21162002
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.17908981
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12606581
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.10819758
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10319499
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00946922
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93418961
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89734821
22E2F1_21310950_ChIP-Seq_MCF-7_Human1.84547781
23* VDR_23849224_ChIP-Seq_CD4+_Human1.79158181
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77189668
25* MYC_18555785_ChIP-Seq_MESCs_Mouse1.74355049
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70337951
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68731746
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64759281
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64202080
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.61399425
31FOXP3_21729870_ChIP-Seq_TREG_Human1.58868888
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56928229
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56242177
34EWS_26573619_Chip-Seq_HEK293_Human1.54805823
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52448496
36* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51896707
37* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51595313
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50859965
39* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50170307
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49094137
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45869516
42* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44914539
43AR_21909140_ChIP-Seq_LNCAP_Human1.43671795
44FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.42481637
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42348270
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41586346
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.41087971
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40061701
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.38964975
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37212331
51DCP1A_22483619_ChIP-Seq_HELA_Human1.37012641
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36874194
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36323675
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34338160
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.33451503
56* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32817721
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32723829
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30088041
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29526128
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29387467
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25512625
62* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24703709
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23179246
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23179246
65MYB_26560356_Chip-Seq_TH2_Human1.22888729
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22508225
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.20411491
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.19935837
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19446081
70* SOX17_20123909_ChIP-Seq_XEN_Mouse1.17802056
71TTF2_22483619_ChIP-Seq_HELA_Human1.17507553
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17163223
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.15643918
74* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15530992
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15396798
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13128987
77* CHD1_26751641_Chip-Seq_LNCaP_Human1.11945663
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11136531
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11066147
80* GABP_19822575_ChIP-Seq_HepG2_Human1.09527098
81* ETS1_20019798_ChIP-Seq_JURKAT_Human1.08781891
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08079220
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.07943662
84* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05751004
85* SPI1_23547873_ChIP-Seq_NB4_Human1.05333251
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04615109
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.03081229
88* TFEB_21752829_ChIP-Seq_HELA_Human1.02078950
89ZNF274_21170338_ChIP-Seq_K562_Hela1.01917342
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01321677
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01287017
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01232364
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01009363
94* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00940131
95* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00614824
96KDM5A_27292631_Chip-Seq_BREAST_Human1.00581597
97* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00100055
98GATA1_22025678_ChIP-Seq_K562_Human1.00006619
99* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99999194
100IRF1_19129219_ChIP-ChIP_H3396_Human0.99960447
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99148753
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99143923
103NMYC_18555785_Chip-Seq_ESCs_Mouse0.98832438
104MYB_26560356_Chip-Seq_TH1_Human0.98821409
105* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98286368
106SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97977632
107CDX2_22108803_ChIP-Seq_LS180_Human0.97863876
108NANOG_18555785_Chip-Seq_ESCs_Mouse0.95738845
109* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95577170
110PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95349975
111P53_22387025_ChIP-Seq_ESCs_Mouse0.95331967
112OCT4_18555785_Chip-Seq_ESCs_Mouse0.94953367
113BRD4_25478319_ChIP-Seq_HGPS_Human0.94950049
114MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94500164
115* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93305654
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93131424
117ELK1_22589737_ChIP-Seq_MCF10A_Human0.92533766
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92376764
119CIITA_25753668_ChIP-Seq_RAJI_Human0.92255690
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92115587
121FUS_26573619_Chip-Seq_HEK293_Human0.92024431
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.91944144
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91855895
124GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91063312
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90381501
126ELF5_23300383_ChIP-Seq_T47D_Human0.90318754
127SRF_21415370_ChIP-Seq_HL-1_Mouse0.90080223
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89993393
129EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89468929
130ZFX_18555785_Chip-Seq_ESCs_Mouse0.89429267
131* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88814240
132P300_18555785_Chip-Seq_ESCs_Mouse0.88035650
133MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87597301
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86878135
135KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86052541
136KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86052541
137KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86052541
138EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84329703
139* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.82461436
140* GATA6_25053715_ChIP-Seq_YYC3_Human0.81419563
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80854014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.15858349
2MP0005410_abnormal_fertilization2.80288923
3MP0008007_abnormal_cellular_replicative2.79584269
4MP0008058_abnormal_DNA_repair2.61073552
5MP0002877_abnormal_melanocyte_morpholog2.53738531
6MP0003693_abnormal_embryo_hatching2.42866400
7MP0010094_abnormal_chromosome_stability2.42619136
8MP0009697_abnormal_copulation2.15961639
9MP0008438_abnormal_cutaneous_collagen1.96881575
10MP0008057_abnormal_DNA_replication1.96772058
11MP0003111_abnormal_nucleus_morphology1.96330338
12MP0006054_spinal_hemorrhage1.91179272
13MP0010307_abnormal_tumor_latency1.86387808
14MP0003950_abnormal_plasma_membrane1.85805619
15MP0003077_abnormal_cell_cycle1.83617296
16MP0004233_abnormal_muscle_weight1.81731041
17MP0003718_maternal_effect1.80810809
18MP0002210_abnormal_sex_determination1.80417539
19MP0001929_abnormal_gametogenesis1.79405309
20MP0004264_abnormal_extraembryonic_tissu1.75486172
21MP0005503_abnormal_tendon_morphology1.74280688
22MP0003705_abnormal_hypodermis_morpholog1.54219677
23MP0001697_abnormal_embryo_size1.52621906
24MP0002009_preneoplasia1.51755592
25MP0003698_abnormal_male_reproductive1.51522926
26MP0004957_abnormal_blastocyst_morpholog1.51063855
27MP0000015_abnormal_ear_pigmentation1.48705900
28MP0003121_genomic_imprinting1.48604518
29MP0003123_paternal_imprinting1.46584581
30MP0010234_abnormal_vibrissa_follicle1.46228752
31MP0001919_abnormal_reproductive_system1.46223374
32MP0002160_abnormal_reproductive_system1.44380884
33MP0001145_abnormal_male_reproductive1.42625001
34MP0005171_absent_coat_pigmentation1.41171474
35MP0003786_premature_aging1.41034864
36MP0005389_reproductive_system_phenotype1.39678624
37MP0002086_abnormal_extraembryonic_tissu1.36117286
38MP0003221_abnormal_cardiomyocyte_apopto1.33408904
39MP0003279_aneurysm1.32860964
40MP0002084_abnormal_developmental_patter1.32742972
41MP0001661_extended_life_span1.32236446
42MP0009672_abnormal_birth_weight1.30369570
43MP0003136_yellow_coat_color1.27502196
44MP0008932_abnormal_embryonic_tissue1.26377225
45MP0000427_abnormal_hair_cycle1.26218194
46MP0004808_abnormal_hematopoietic_stem1.26135716
47MP0002080_prenatal_lethality1.24902966
48MP0003763_abnormal_thymus_physiology1.24333543
49MP0000653_abnormal_sex_gland1.24210204
50MP0003890_abnormal_embryonic-extraembry1.24139019
51MP0003943_abnormal_hepatobiliary_system1.23151524
52MP0005395_other_phenotype1.22922921
53MP0005076_abnormal_cell_differentiation1.22646480
54MP0010678_abnormal_skin_adnexa1.21161112
55MP0001835_abnormal_antigen_presentation1.20046495
56MP0002085_abnormal_embryonic_tissue1.20030761
57MP0004185_abnormal_adipocyte_glucose1.17345842
58MP0010386_abnormal_urinary_bladder1.16599043
59MP0003656_abnormal_erythrocyte_physiolo1.16428798
60MP0010352_gastrointestinal_tract_polyps1.15438039
61MP0001188_hyperpigmentation1.15326114
62MP0010368_abnormal_lymphatic_system1.15137561
63MP0009703_decreased_birth_body1.14425347
64MP0000537_abnormal_urethra_morphology1.13932042
65MP0006292_abnormal_olfactory_placode1.11821687
66MP0009053_abnormal_anal_canal1.11759088
67MP0002006_tumorigenesis1.11135328
68MP0002928_abnormal_bile_duct1.10755704
69MP0001243_abnormal_dermal_layer1.10609565
70MP0005621_abnormal_cell_physiology1.10467471
71MP0004272_abnormal_basement_membrane1.08578311
72MP0005257_abnormal_intraocular_pressure1.08039189
73MP0005647_abnormal_sex_gland1.07804206
74MP0000428_abnormal_craniofacial_morphol1.07262526
75MP0000858_altered_metastatic_potential1.07181007
76MP0000350_abnormal_cell_proliferation1.06481787
77MP0009333_abnormal_splenocyte_physiolog1.04132927
78MP0002693_abnormal_pancreas_physiology1.03304821
79MP0000358_abnormal_cell_content/1.02727249
80MP0001119_abnormal_female_reproductive1.02051184
81MP0000383_abnormal_hair_follicle1.00715731
82MP0003787_abnormal_imprinting1.00114138
83MP0005380_embryogenesis_phenotype0.98964738
84MP0001672_abnormal_embryogenesis/_devel0.98964738
85MP0002254_reproductive_system_inflammat0.98873890
86MP0002166_altered_tumor_susceptibility0.98414072
87MP0003122_maternal_imprinting0.98254637
88MP0003315_abnormal_perineum_morphology0.98225168
89MP0000678_abnormal_parathyroid_gland0.97182515
90MP0003195_calcinosis0.96304647
91MP0005671_abnormal_response_to0.95978764
92MP0005384_cellular_phenotype0.95732158
93MP0003941_abnormal_skin_development0.95054826
94MP0003984_embryonic_growth_retardation0.94845834
95MP0003448_altered_tumor_morphology0.93238973
96MP0002933_joint_inflammation0.93114470
97MP0002088_abnormal_embryonic_growth/wei0.91631351
98MP0005623_abnormal_meninges_morphology0.90951973
99MP0005310_abnormal_salivary_gland0.90279584
100MP0003868_abnormal_feces_composition0.89848635
101MP0002938_white_spotting0.88630239
102MP0004197_abnormal_fetal_growth/weight/0.87959046
103MP0005174_abnormal_tail_pigmentation0.87936088
104MP0003385_abnormal_body_wall0.86749118
105MP0005367_renal/urinary_system_phenotyp0.86628096
106MP0000516_abnormal_urinary_system0.86628096
107MP0002163_abnormal_gland_morphology0.86514851
108MP0002396_abnormal_hematopoietic_system0.85397638
109MP0004134_abnormal_chest_morphology0.85192345
110MP0003567_abnormal_fetal_cardiomyocyte0.85135736
111MP0002452_abnormal_antigen_presenting0.85120815
112MP0005501_abnormal_skin_physiology0.83820312
113MP0002796_impaired_skin_barrier0.83798856
114MP0000627_abnormal_mammary_gland0.83285403
115MP0002168_other_aberrant_phenotype0.83130861
116MP0005408_hypopigmentation0.82454370
117MP0003436_decreased_susceptibility_to0.82329860
118MP0000703_abnormal_thymus_morphology0.82307640
119MP0003937_abnormal_limbs/digits/tail_de0.81806439
120MP0009384_cardiac_valve_regurgitation0.81720075
121MP0003091_abnormal_cell_migration0.81174611
122MP0002111_abnormal_tail_morphology0.81048295
123MP0002876_abnormal_thyroid_physiology0.81039152
124MP0001346_abnormal_lacrimal_gland0.80834023
125MP0000313_abnormal_cell_death0.80713858
126MP0000432_abnormal_head_morphology0.80684874
127MP0001986_abnormal_taste_sensitivity0.80674068
128MP0005451_abnormal_body_composition0.80563770
129MP0008260_abnormal_autophagy0.80350001
130MP0002697_abnormal_eye_size0.79781868
131MP0001186_pigmentation_phenotype0.79743028
132MP0001348_abnormal_lacrimal_gland0.79599735
133MP0002398_abnormal_bone_marrow0.79500698
134MP0002177_abnormal_outer_ear0.79155804
135MP0005275_abnormal_skin_tensile0.78709317
136MP0002060_abnormal_skin_morphology0.78502709
137MP0002419_abnormal_innate_immunity0.78384377
138MP0001730_embryonic_growth_arrest0.78310934
139MP0001286_abnormal_eye_development0.78306518
140MP0003566_abnormal_cell_adhesion0.78212106
141MP0005000_abnormal_immune_tolerance0.77992370
142MP0002148_abnormal_hypersensitivity_rea0.77780045
143MP0002277_abnormal_respiratory_mucosa0.77756649
144MP0000490_abnormal_crypts_of0.77581079
145MP0001915_intracranial_hemorrhage0.77470204
146MP0001216_abnormal_epidermal_layer0.77349391
147MP0005508_abnormal_skeleton_morphology0.77081216
148MP0002420_abnormal_adaptive_immunity0.76278751
149MP0002161_abnormal_fertility/fecundity0.75952117
150MP0000371_diluted_coat_color0.75752539
151MP0001819_abnormal_immune_cell0.75075791
152MP0002019_abnormal_tumor_incidence0.74728890
153MP0000647_abnormal_sebaceous_gland0.72269961
154MP0001293_anophthalmia0.72127160
155MP0005197_abnormal_uvea_morphology0.70983517
156MP0000569_abnormal_digit_pigmentation0.67863682
157MP0002925_abnormal_cardiovascular_devel0.67644335
158MP0005187_abnormal_penis_morphology0.66450923

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.88091889
2Dynein arm defect of respiratory motile cilia (HP:0012255)3.81030384
3Absent/shortened dynein arms (HP:0200106)3.81030384
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.45411523
5Chromsome breakage (HP:0040012)3.23796088
6Central scotoma (HP:0000603)3.22973400
7Abnormal respiratory motile cilium physiology (HP:0012261)3.18595047
8Volvulus (HP:0002580)3.11838262
9Rhinitis (HP:0012384)2.92731452
10Proximal tubulopathy (HP:0000114)2.90236825
11Degeneration of anterior horn cells (HP:0002398)2.75083907
12Abnormality of the anterior horn cell (HP:0006802)2.75083907
13Abnormality of macular pigmentation (HP:0008002)2.72911250
14Abnormal respiratory motile cilium morphology (HP:0005938)2.71769905
15Abnormal respiratory epithelium morphology (HP:0012253)2.71769905
16Upper motor neuron abnormality (HP:0002127)2.69749345
17Abnormal ciliary motility (HP:0012262)2.67725574
18Rhabdomyosarcoma (HP:0002859)2.66369367
19Embryonal renal neoplasm (HP:0011794)2.56538412
20Nephroblastoma (Wilms tumor) (HP:0002667)2.54944118
2111 pairs of ribs (HP:0000878)2.54769426
22Type I transferrin isoform profile (HP:0003642)2.51579547
23Chronic bronchitis (HP:0004469)2.50928563
24Abnormal spermatogenesis (HP:0008669)2.48401899
25Ectopic kidney (HP:0000086)2.45025761
26Curly hair (HP:0002212)2.43723838
27Overlapping toe (HP:0001845)2.42298522
28Abnormality of dentin (HP:0010299)2.36503911
29Prostate neoplasm (HP:0100787)2.35743026
30Meckel diverticulum (HP:0002245)2.35270244
31Increased nuchal translucency (HP:0010880)2.34145276
32Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.31243469
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.30310279
34Abnormality of chromosome stability (HP:0003220)2.29490679
35Absent radius (HP:0003974)2.28526428
36Nephronophthisis (HP:0000090)2.28188490
37Osteolytic defects of the hand bones (HP:0009699)2.25248739
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.25248739
39Tubulointerstitial nephritis (HP:0001970)2.25175065
40Hypoplasia of the pons (HP:0012110)2.22525467
41Abnormality of the lower motor neuron (HP:0002366)2.21601786
42Biliary tract neoplasm (HP:0100574)2.21551775
43Bronchiectasis (HP:0002110)2.20829207
44Thyroid carcinoma (HP:0002890)2.20590202
45Abnormality of the duodenum (HP:0002246)2.19941668
46Ependymoma (HP:0002888)2.18212291
47Premature rupture of membranes (HP:0001788)2.16478578
48Bronchitis (HP:0012387)2.15348064
49Cystic hygroma (HP:0000476)2.15216694
50Abnormal pancreas size (HP:0012094)2.12651765
51Abnormality of the ileum (HP:0001549)2.12475277
52Clubbing of toes (HP:0100760)2.12194878
53Unilateral renal agenesis (HP:0000122)2.11461254
54Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.08387098
55Syringomyelia (HP:0003396)2.07324239
56Spinal cord lesions (HP:0100561)2.07324239
57Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.06502677
58Deviation of the thumb (HP:0009603)2.05782522
59Absent frontal sinuses (HP:0002688)2.04603882
60Cortical dysplasia (HP:0002539)2.02359285
61Abnormality of the pons (HP:0007361)2.02219148
62Abnormality of the carotid arteries (HP:0005344)2.02170647
63Medulloblastoma (HP:0002885)2.01862477
64Reduced antithrombin III activity (HP:0001976)2.01645959
65Gastrointestinal carcinoma (HP:0002672)2.00991185
66Malignant gastrointestinal tract tumors (HP:0006749)2.00991185
67Proximal placement of thumb (HP:0009623)1.98622301
68Multiple enchondromatosis (HP:0005701)1.96884784
69Absent forearm bone (HP:0003953)1.96878738
70Aplasia involving forearm bones (HP:0009822)1.96878738
71Scotoma (HP:0000575)1.96787914
72Azoospermia (HP:0000027)1.95584634
73True hermaphroditism (HP:0010459)1.94779989
74Glioma (HP:0009733)1.93737069
75Progressive external ophthalmoplegia (HP:0000590)1.93075175
76Recurrent bronchitis (HP:0002837)1.91627731
77Leiomyosarcoma (HP:0100243)1.90900715
78Uterine leiomyosarcoma (HP:0002891)1.90900715
79Abnormality of the preputium (HP:0100587)1.90402932
80Pancreatic fibrosis (HP:0100732)1.89765716
81Abnormal protein glycosylation (HP:0012346)1.88325123
82Abnormal glycosylation (HP:0012345)1.88325123
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88325123
84Abnormal protein N-linked glycosylation (HP:0012347)1.88325123
85Selective tooth agenesis (HP:0001592)1.87745310
86Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.86983135
87Uterine neoplasm (HP:0010784)1.84397609
88Facial cleft (HP:0002006)1.83942146
89Fibular hypoplasia (HP:0003038)1.83633566
90Neoplasm of the colon (HP:0100273)1.83075129
91Impulsivity (HP:0100710)1.82726490
92Transitional cell carcinoma of the bladder (HP:0006740)1.82285884
93Capillary hemangiomas (HP:0005306)1.81944941
94Deep philtrum (HP:0002002)1.81533373
95Shoulder girdle muscle weakness (HP:0003547)1.80848777
96Abnormality of the frontal sinuses (HP:0002687)1.80389174
97Median cleft lip (HP:0000161)1.80342225
98Abnormality of the renal medulla (HP:0100957)1.80011510
99Abnormality of the astrocytes (HP:0100707)1.79966550
100Astrocytoma (HP:0009592)1.79966550
101Abnormal lung lobation (HP:0002101)1.79530721
102Abnormality of the metopic suture (HP:0005556)1.78977521
103Long eyelashes (HP:0000527)1.78375525
104Neoplasm of striated muscle (HP:0009728)1.78321716
105Embryonal neoplasm (HP:0002898)1.77689665
106Short middle phalanx of the 5th finger (HP:0004220)1.77118993
107Bladder neoplasm (HP:0009725)1.77035160
108Bladder carcinoma (HP:0002862)1.77035160
109Cervical subluxation (HP:0003308)1.76553733
110Breast carcinoma (HP:0003002)1.75856770
111Small intestinal stenosis (HP:0012848)1.74797508
112Duodenal stenosis (HP:0100867)1.74797508
113Birth length less than 3rd percentile (HP:0003561)1.74270828
114Duplicated collecting system (HP:0000081)1.72906613
115Prominent metopic ridge (HP:0005487)1.72444818
116Missing ribs (HP:0000921)1.71680331
117Glucose intolerance (HP:0000833)1.70977906
118Arterial tortuosity (HP:0005116)1.70899405
119Flat capital femoral epiphysis (HP:0003370)1.70686198
120Vascular tortuosity (HP:0004948)1.69727010
121Asymmetry of the thorax (HP:0001555)1.68713536
122Optic nerve coloboma (HP:0000588)1.68526392
123Aortic dissection (HP:0002647)1.68399135
124Progressive hearing impairment (HP:0001730)1.68340746
125Cutaneous melanoma (HP:0012056)1.68040941
126Amyotrophic lateral sclerosis (HP:0007354)1.67913086
127Urethral obstruction (HP:0000796)1.67506524
128Abnormality of methionine metabolism (HP:0010901)1.67064894
129Relative macrocephaly (HP:0004482)1.66913908
130Cafe-au-lait spot (HP:0000957)1.66660750
131Recurrent sinusitis (HP:0011108)1.66502071
132Natal tooth (HP:0000695)1.66416709
133Postaxial foot polydactyly (HP:0001830)1.65967561
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.65568235
135Hypoplasia of the fovea (HP:0007750)1.65568235
136IgA deficiency (HP:0002720)1.64610654
137Septate vagina (HP:0001153)1.64179904
138Spondylolisthesis (HP:0003302)1.63786353
139Acute myeloid leukemia (HP:0004808)1.63296565
140Orthostatic hypotension (HP:0001278)1.62996644
141Wide intermamillary distance (HP:0006610)1.62892557
142Low anterior hairline (HP:0000294)1.62649557
143Myelodysplasia (HP:0002863)1.62210823
144Supernumerary spleens (HP:0009799)1.62148739
145Choanal atresia (HP:0000453)1.62052685
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.60931605
147Bone marrow hypocellularity (HP:0005528)1.60207546
148Abnormality of the phalanges of the hallux (HP:0010057)1.58110170
149Microglossia (HP:0000171)1.57800742
150Infertility (HP:0000789)1.57613986
151Abnormal delayed hypersensitivity skin test (HP:0002963)1.56842102
152Thoracolumbar scoliosis (HP:0002944)1.56616449
153Abnormality of the nasal septum (HP:0000419)1.55729104
154Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.55063850
155Short 4th metacarpal (HP:0010044)1.55063850
156Papillary thyroid carcinoma (HP:0002895)1.54769509
157Aplastic anemia (HP:0001915)1.54436426
158Mesomelia (HP:0003027)1.54321488
159Poor head control (HP:0002421)1.54131786
160Nasal polyposis (HP:0100582)1.54001658
161Preaxial hand polydactyly (HP:0001177)1.53717771
162Stage 5 chronic kidney disease (HP:0003774)1.53391434
163Osteomalacia (HP:0002749)1.52251087
164Follicular hyperkeratosis (HP:0007502)1.51947512
165Pancreatic cysts (HP:0001737)1.51403984
166Sloping forehead (HP:0000340)1.51258928
167Tongue fasciculations (HP:0001308)1.50321228
168Abnormality of the fingertips (HP:0001211)1.50012431
169Abnormality of the renal collecting system (HP:0004742)1.49794387

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.54631664
2MKNK23.10417431
3TESK12.62713476
4BCR2.58090547
5ZAK2.55805478
6IRAK32.52448970
7PASK2.44575874
8CDC72.34099284
9MKNK12.33666734
10NEK12.31791057
11TAF12.16402971
12IRAK42.14600374
13PLK42.12511272
14MST1R2.10792992
15SRPK12.00598453
16AKT31.92789925
17PDK41.91253363
18PDK31.91253363
19STK38L1.90355790
20BRSK21.87737468
21CASK1.85963704
22SCYL21.84029408
23MAP3K141.80079635
24TXK1.73842110
25NLK1.72659345
26CDK121.71263751
27FRK1.71181361
28STK31.67738926
29MET1.56565039
30CLK11.55733974
31STK391.50595563
32TRIM281.47741563
33EIF2AK21.47213919
34LATS11.43396840
35YES11.40560705
36MST41.38878679
37TSSK61.38073909
38WEE11.33766916
39ERBB31.31704996
40NEK91.28853524
41ERBB41.26256462
42PDK21.21819039
43EIF2AK11.21098976
44PLK31.20351866
45STK161.19702948
46VRK11.17958789
47PRKD31.17250502
48BMPR21.15917903
49TAOK31.14381301
50CAMK1D1.14342583
51JAK31.12608697
52IRAK11.12274111
53PIM11.11594982
54ATR1.11383143
55MELK1.08733317
56BRD41.07927881
57BUB11.07310033
58EPHA21.06703343
59STK41.05631177
60LATS21.04404365
61NUAK11.04056268
62TRPM71.04021621
63STK101.01315552
64CHUK1.00086236
65TNIK0.99553520
66STK240.99203081
67TEC0.97587122
68CAMK1G0.96228994
69TTK0.95151448
70PAK40.92896412
71SGK20.92283221
72PLK10.92025835
73NEK20.90374799
74NEK60.89914868
75INSRR0.88350334
76PRPF4B0.87442151
77PDGFRA0.81268662
78CDK70.80672951
79HIPK20.80148778
80ATM0.78684194
81ACVR1B0.76887203
82CHEK10.76277699
83PBK0.76056591
84ZAP700.75855965
85FGFR10.74894118
86MUSK0.74725146
87AURKB0.71820762
88PRKD20.69583965
89MAP3K90.69483045
90PAK20.65589890
91RPS6KA40.64576768
92BMPR1B0.63200446
93PIK3CA0.61711139
94STK380.61002255
95NME10.59806117
96CDK90.59602747
97CHEK20.59405458
98MARK30.59100666
99IKBKB0.55763837
100KSR10.54973074
101MAP3K50.52446589
102RPS6KB10.52139585
103SGK30.52106256
104TESK20.52099425
105TLK10.51982218
106FGFR40.51516004
107CDK40.50687785
108VRK20.50445564
109MAP4K10.49229953
110CDK60.47784719
111LIMK10.44229153
112SIK30.44165799
113PLK20.43554828
114MTOR0.43326212
115CSNK1A1L0.42941249
116MYLK0.42241304
117CDC42BPA0.41935599
118CDK30.41840520
119FER0.41346700
120PRKCI0.40930770
121CDK80.40081166
122FLT30.39683129
123CSNK2A10.39617101
124RPS6KB20.39258588
125CDK20.38289358
126CDK10.38269622
127PNCK0.37325409
128PTK20.37230239
129BTK0.37154436
130MAPK150.37127518
131IRAK20.35985935
132ALK0.35680782
133SMG10.35028146
134IKBKE0.34697896
135PDGFRB0.34646474
136EPHA30.34086915
137CSNK1E0.32466805
138BRSK10.31825994
139MAP3K80.31242489
140CSNK2A20.28043428
141MAP3K130.25360297
142CSNK1G10.25121487
143PRKDC0.24947398

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.86061729
2Fanconi anemia pathway_Homo sapiens_hsa034602.45632138
3DNA replication_Homo sapiens_hsa030302.36380613
4Basal transcription factors_Homo sapiens_hsa030222.26081006
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08688001
6Mismatch repair_Homo sapiens_hsa034302.07580380
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.06166060
8Antigen processing and presentation_Homo sapiens_hsa046122.03366466
9Cell cycle_Homo sapiens_hsa041101.92942472
10Homologous recombination_Homo sapiens_hsa034401.90502214
11Spliceosome_Homo sapiens_hsa030401.90219937
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.86584106
13RNA transport_Homo sapiens_hsa030131.86089155
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.78062825
15Base excision repair_Homo sapiens_hsa034101.69046762
16Non-homologous end-joining_Homo sapiens_hsa034501.67160621
17Nucleotide excision repair_Homo sapiens_hsa034201.65240552
18RNA degradation_Homo sapiens_hsa030181.63889489
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63245786
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59307057
21Graft-versus-host disease_Homo sapiens_hsa053321.59095311
22mRNA surveillance pathway_Homo sapiens_hsa030151.57420961
23Propanoate metabolism_Homo sapiens_hsa006401.56150715
24One carbon pool by folate_Homo sapiens_hsa006701.53070836
25Sulfur metabolism_Homo sapiens_hsa009201.51816389
26Measles_Homo sapiens_hsa051621.45042980
27p53 signaling pathway_Homo sapiens_hsa041151.44956925
28Proteasome_Homo sapiens_hsa030501.44156493
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43894523
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.43376534
31Herpes simplex infection_Homo sapiens_hsa051681.36921794
32Legionellosis_Homo sapiens_hsa051341.33182334
33Type I diabetes mellitus_Homo sapiens_hsa049401.28012892
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27901134
35Allograft rejection_Homo sapiens_hsa053301.26631516
36RNA polymerase_Homo sapiens_hsa030201.26309327
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24611366
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.22289483
39Fatty acid biosynthesis_Homo sapiens_hsa000611.21653284
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21290313
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20317389
42Epstein-Barr virus infection_Homo sapiens_hsa051691.17798648
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16644452
44Pyrimidine metabolism_Homo sapiens_hsa002401.14440258
45Leishmaniasis_Homo sapiens_hsa051401.12085998
46N-Glycan biosynthesis_Homo sapiens_hsa005101.11522485
47Pyruvate metabolism_Homo sapiens_hsa006201.07977052
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06684945
49Steroid biosynthesis_Homo sapiens_hsa001001.05401238
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05125264
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03468826
52Selenocompound metabolism_Homo sapiens_hsa004501.03207565
53Prostate cancer_Homo sapiens_hsa052151.02291952
54Vitamin B6 metabolism_Homo sapiens_hsa007500.97939383
55Viral carcinogenesis_Homo sapiens_hsa052030.97900412
56Influenza A_Homo sapiens_hsa051640.97862987
57Asthma_Homo sapiens_hsa053100.97297646
58Other glycan degradation_Homo sapiens_hsa005110.95060115
59Small cell lung cancer_Homo sapiens_hsa052220.95032379
60Adherens junction_Homo sapiens_hsa045200.91038568
61Glutathione metabolism_Homo sapiens_hsa004800.90530296
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88279033
63HTLV-I infection_Homo sapiens_hsa051660.87719585
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87155069
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86847649
66Primary immunodeficiency_Homo sapiens_hsa053400.86091618
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85440147
68Purine metabolism_Homo sapiens_hsa002300.85370667
69Malaria_Homo sapiens_hsa051440.82288648
70Oocyte meiosis_Homo sapiens_hsa041140.80877439
71Toxoplasmosis_Homo sapiens_hsa051450.79331163
72Hepatitis B_Homo sapiens_hsa051610.78347138
73Hippo signaling pathway_Homo sapiens_hsa043900.77805626
74Proteoglycans in cancer_Homo sapiens_hsa052050.77705563
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77628964
76Hematopoietic cell lineage_Homo sapiens_hsa046400.75949971
77ECM-receptor interaction_Homo sapiens_hsa045120.75753664
78Biosynthesis of amino acids_Homo sapiens_hsa012300.75438760
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73816512
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73802810
81Fatty acid metabolism_Homo sapiens_hsa012120.73412186
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72807638
83Viral myocarditis_Homo sapiens_hsa054160.72666541
84Autoimmune thyroid disease_Homo sapiens_hsa053200.72343284
85MicroRNAs in cancer_Homo sapiens_hsa052060.72328307
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.71270592
87Apoptosis_Homo sapiens_hsa042100.71241531
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71077457
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68667662
90TNF signaling pathway_Homo sapiens_hsa046680.67270420
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66989158
92TGF-beta signaling pathway_Homo sapiens_hsa043500.66782199
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.64918630
94Pancreatic cancer_Homo sapiens_hsa052120.64634435
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64397663
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64106092
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64037248
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63969062
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63020313
100Vibrio cholerae infection_Homo sapiens_hsa051100.62471906
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62274823
102Renin-angiotensin system_Homo sapiens_hsa046140.61671103
103Thyroid cancer_Homo sapiens_hsa052160.60154573
104Sphingolipid metabolism_Homo sapiens_hsa006000.59217134
105Phagosome_Homo sapiens_hsa041450.58291426
106Rheumatoid arthritis_Homo sapiens_hsa053230.58086270
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58050223
108Colorectal cancer_Homo sapiens_hsa052100.56721510
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56643220
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56139830
111Bladder cancer_Homo sapiens_hsa052190.56045234
112Tuberculosis_Homo sapiens_hsa051520.54885594
113Carbon metabolism_Homo sapiens_hsa012000.54356749
114Salmonella infection_Homo sapiens_hsa051320.51954730
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.50492374
116Systemic lupus erythematosus_Homo sapiens_hsa053220.49724561
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48525149
118Fatty acid elongation_Homo sapiens_hsa000620.47042561
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.46933564
120Pertussis_Homo sapiens_hsa051330.46494250
121FoxO signaling pathway_Homo sapiens_hsa040680.46474419
122Hedgehog signaling pathway_Homo sapiens_hsa043400.46337270
123Tight junction_Homo sapiens_hsa045300.46218222
124Shigellosis_Homo sapiens_hsa051310.45779732
125Osteoclast differentiation_Homo sapiens_hsa043800.45616021
126Focal adhesion_Homo sapiens_hsa045100.45471203
127T cell receptor signaling pathway_Homo sapiens_hsa046600.41220934
128Lysine degradation_Homo sapiens_hsa003100.40783921
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40124987
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39770756
131Acute myeloid leukemia_Homo sapiens_hsa052210.39716396
132Arachidonic acid metabolism_Homo sapiens_hsa005900.38862087
133Pathways in cancer_Homo sapiens_hsa052000.38744253
134Protein digestion and absorption_Homo sapiens_hsa049740.38694022
135Chronic myeloid leukemia_Homo sapiens_hsa052200.38683836
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36057532
137Pentose phosphate pathway_Homo sapiens_hsa000300.35554591
138Melanoma_Homo sapiens_hsa052180.35132473
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31277392
140Non-small cell lung cancer_Homo sapiens_hsa052230.30470018
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26320436
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26207997
143Inositol phosphate metabolism_Homo sapiens_hsa005620.25158130
144Fatty acid degradation_Homo sapiens_hsa000710.23100012
145Basal cell carcinoma_Homo sapiens_hsa052170.21718615
146Wnt signaling pathway_Homo sapiens_hsa043100.20378397

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