SEC24A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.64188805
2L-phenylalanine catabolic process (GO:0006559)6.64188805
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.40311707
4L-phenylalanine metabolic process (GO:0006558)6.40311707
5aromatic amino acid family catabolic process (GO:0009074)6.24590192
6* COPII vesicle coating (GO:0048208)5.89641488
7tryptophan catabolic process (GO:0006569)5.88190999
8indole-containing compound catabolic process (GO:0042436)5.88190999
9indolalkylamine catabolic process (GO:0046218)5.88190999
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.81137644
11Golgi transport vesicle coating (GO:0048200)5.68412078
12COPI coating of Golgi vesicle (GO:0048205)5.68412078
13tryptophan metabolic process (GO:0006568)5.58360875
14nuclear pore complex assembly (GO:0051292)5.52459274
15kynurenine metabolic process (GO:0070189)5.36445344
16urea cycle (GO:0000050)5.22313097
17urea metabolic process (GO:0019627)5.22313097
18sulfur amino acid catabolic process (GO:0000098)5.20956739
19glyoxylate metabolic process (GO:0046487)5.19064063
20bile acid biosynthetic process (GO:0006699)5.17668311
21peptidyl-glutamic acid carboxylation (GO:0017187)5.12891748
22protein carboxylation (GO:0018214)5.12891748
23high-density lipoprotein particle remodeling (GO:0034375)4.99359600
24intestinal cholesterol absorption (GO:0030299)4.98450527
25acylglycerol homeostasis (GO:0055090)4.96700460
26triglyceride homeostasis (GO:0070328)4.96700460
27regulation of protein activation cascade (GO:2000257)4.83382517
28negative regulation of fibrinolysis (GO:0051918)4.83232271
29bile acid metabolic process (GO:0008206)4.79579285
30nitrogen cycle metabolic process (GO:0071941)4.76403053
31complement activation, alternative pathway (GO:0006957)4.76143416
32regulation of fibrinolysis (GO:0051917)4.73648987
33alpha-linolenic acid metabolic process (GO:0036109)4.72509329
34cysteine metabolic process (GO:0006534)4.68281857
35very-low-density lipoprotein particle assembly (GO:0034379)4.64812860
36serine family amino acid catabolic process (GO:0009071)4.62885460
37homocysteine metabolic process (GO:0050667)4.61457791
38cholesterol efflux (GO:0033344)4.57491980
39nuclear pore organization (GO:0006999)4.56503962
40aromatic amino acid family metabolic process (GO:0009072)4.52496716
41regulation of complement activation (GO:0030449)4.51502168
42cellular glucuronidation (GO:0052695)4.50921158
43reverse cholesterol transport (GO:0043691)4.49308564
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.49206915
45regulation of cholesterol esterification (GO:0010872)4.48313695
46phospholipid efflux (GO:0033700)4.46555706
47regulation of triglyceride catabolic process (GO:0010896)4.40250743
48macromolecular complex remodeling (GO:0034367)4.32487306
49plasma lipoprotein particle remodeling (GO:0034369)4.32487306
50protein-lipid complex remodeling (GO:0034368)4.32487306
51bile acid and bile salt transport (GO:0015721)4.30224483
52plasma lipoprotein particle assembly (GO:0034377)4.27314832
53indolalkylamine metabolic process (GO:0006586)4.23665750
54tyrosine metabolic process (GO:0006570)4.18691956
55regulation of bile acid biosynthetic process (GO:0070857)4.17493817
56cellular biogenic amine catabolic process (GO:0042402)4.16592913
57amine catabolic process (GO:0009310)4.16592913
58amino-acid betaine metabolic process (GO:0006577)4.13076642
59negative regulation of cholesterol transport (GO:0032375)4.09251755
60negative regulation of sterol transport (GO:0032372)4.09251755
61cytolysis (GO:0019835)4.08508759
62negative regulation of fatty acid biosynthetic process (GO:0045717)4.07481578
63proline biosynthetic process (GO:0006561)4.05723049
64alpha-amino acid catabolic process (GO:1901606)4.05486213
65* vesicle coating (GO:0006901)4.05458722
66glucuronate metabolic process (GO:0019585)4.01473045
67uronic acid metabolic process (GO:0006063)4.01473045
68plasma lipoprotein particle clearance (GO:0034381)3.98392631
69pore complex assembly (GO:0046931)3.95898419
70cell adhesion mediated by integrin (GO:0033627)3.93215464
71ER overload response (GO:0006983)3.93100571
72cholesterol homeostasis (GO:0042632)3.88238479
73embryonic process involved in female pregnancy (GO:0060136)3.87849821
74drug catabolic process (GO:0042737)3.86637399
75positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.85677225
76proline metabolic process (GO:0006560)3.84385633
77sterol homeostasis (GO:0055092)3.82899217
78lipoprotein metabolic process (GO:0042157)3.80509523
79coenzyme catabolic process (GO:0009109)3.79333267
80alkaloid metabolic process (GO:0009820)3.76864699
81protein-lipid complex assembly (GO:0065005)3.75554079
82positive regulation of lipoprotein lipase activity (GO:0051006)3.73207947
83positive regulation of triglyceride lipase activity (GO:0061365)3.73207947
84phospholipid homeostasis (GO:0055091)3.72537175
85cellular amino acid catabolic process (GO:0009063)3.72287345
86glutamine family amino acid biosynthetic process (GO:0009084)3.69899077
87benzene-containing compound metabolic process (GO:0042537)3.69713494
88imidazole-containing compound metabolic process (GO:0052803)3.69316718
89nucleotide-sugar biosynthetic process (GO:0009226)3.68874202
90fibrinolysis (GO:0042730)3.68712564
91skin morphogenesis (GO:0043589)3.68036614
92lysine catabolic process (GO:0006554)3.66467181
93lysine metabolic process (GO:0006553)3.66467181
94UDP-N-acetylglucosamine metabolic process (GO:0006047)3.65368403
95glycine metabolic process (GO:0006544)3.64720287
96NAD biosynthetic process (GO:0009435)3.61569818
97plasma lipoprotein particle organization (GO:0071827)3.59293038
98maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.58962161
99serine family amino acid metabolic process (GO:0009069)3.57286190
100epoxygenase P450 pathway (GO:0019373)3.52732323
101intestinal absorption (GO:0050892)3.52625991
102low-density lipoprotein particle remodeling (GO:0034374)3.47624777
103positive regulation of lipid catabolic process (GO:0050996)3.47603722
104heme transport (GO:0015886)3.45469984
105complement activation, classical pathway (GO:0006958)3.44403894
106pyridine nucleotide biosynthetic process (GO:0019363)3.41747181
107nicotinamide nucleotide biosynthetic process (GO:0019359)3.41747181
108glutamate metabolic process (GO:0006536)3.41479630
109complement activation (GO:0006956)3.35695358
110protein-lipid complex subunit organization (GO:0071825)3.33626910
111cofactor catabolic process (GO:0051187)3.32691060
112arginine metabolic process (GO:0006525)3.32139335
113acetyl-CoA metabolic process (GO:0006084)3.29950983
114cellular modified amino acid catabolic process (GO:0042219)3.29600884
115protein activation cascade (GO:0072376)3.29170248
116activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.21929928
117regulation of transforming growth factor beta2 production (GO:0032909)3.17702673
118positive regulation of nuclease activity (GO:0032075)3.14523442
119regulation of RNA export from nucleus (GO:0046831)3.11878076
120endoplasmic reticulum unfolded protein response (GO:0030968)3.04912353
121regulation of transforming growth factor beta1 production (GO:0032908)3.00362931
122ER-nucleus signaling pathway (GO:0006984)3.00059682
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.99523964
124regulation of nuclease activity (GO:0032069)2.98685449
125desmosome organization (GO:0002934)2.98464409
126negative regulation of fatty acid transport (GO:2000192)2.96340172
127negative regulation of lipase activity (GO:0060192)2.91791852
128regulation of cytokine secretion involved in immune response (GO:0002739)2.87770520
129positive regulation of extracellular matrix organization (GO:1903055)2.87291950
130cellular response to unfolded protein (GO:0034620)2.86477651
131regulation of plasminogen activation (GO:0010755)2.85897617
132regulation of heterotypic cell-cell adhesion (GO:0034114)2.85079498
133regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.83349359
134regulation of early endosome to late endosome transport (GO:2000641)2.73943559
135protein retention in ER lumen (GO:0006621)2.69986872
136positive regulation of endothelial cell apoptotic process (GO:2000353)2.67897711
137mitotic sister chromatid cohesion (GO:0007064)2.65035230
138regulation of nucleobase-containing compound transport (GO:0032239)2.62749741
139collagen fibril organization (GO:0030199)2.60825151
140negative regulation of lipid transport (GO:0032369)2.57884842
141lipoprotein transport (GO:0042953)2.57295487
142bundle of His cell to Purkinje myocyte communication (GO:0086069)2.55560284
143chondrocyte development (GO:0002063)2.54735110
144cellular response to topologically incorrect protein (GO:0035967)2.53944225
145midgut development (GO:0007494)2.52265225
146protein hydroxylation (GO:0018126)2.49292781
147negative regulation of DNA repair (GO:0045738)2.48425582
148regulation of transforming growth factor beta production (GO:0071634)2.47970180
149chondrocyte proliferation (GO:0035988)2.47957055
150* regulation of cholesterol homeostasis (GO:2000188)2.47906018
151hypotonic response (GO:0006971)2.45354509
152regulation of endothelial cell apoptotic process (GO:2000351)2.43160837
153mitotic chromosome condensation (GO:0007076)2.41358464
154* protein N-linked glycosylation via asparagine (GO:0018279)2.41064370
155anterior/posterior axis specification, embryo (GO:0008595)2.40643518
156mRNA modification (GO:0016556)2.40549323
157positive regulation of blood coagulation (GO:0030194)2.40495476
158positive regulation of hemostasis (GO:1900048)2.40495476
159acrosome assembly (GO:0001675)2.39315694
160regulation of vitamin metabolic process (GO:0030656)2.39149837
161* peptidyl-asparagine modification (GO:0018196)2.38687934
162endodermal cell differentiation (GO:0035987)2.38629568
163positive regulation of coagulation (GO:0050820)2.38055209
164branching involved in mammary gland duct morphogenesis (GO:0060444)2.35200362
165peptidyl-proline hydroxylation (GO:0019511)2.34661863
166negative regulation of protein activation cascade (GO:2000258)2.33210982
167regulation of metalloenzyme activity (GO:0048552)2.32435942
168positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.31359242
169negative regulation of endothelial cell apoptotic process (GO:2000352)2.29555556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.96319085
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.73497047
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.48762613
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.22801685
5LXR_22158963_ChIP-Seq_LIVER_Mouse6.21798698
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.85469557
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.68349743
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.18588638
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.83239906
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.67254590
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.01422459
12AR_21909140_ChIP-Seq_LNCAP_Human2.98972031
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.94954205
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.80011877
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.76465942
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.71533531
17E2F7_22180533_ChIP-Seq_HELA_Human2.69126574
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34158765
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26507956
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15968587
21SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.12749774
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.97597376
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.97597376
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.85083789
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.81460131
26* BRD4_25478319_ChIP-Seq_HGPS_Human1.77450917
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73711719
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72694581
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69655999
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.65302740
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65212915
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65212546
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.59954860
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59746524
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59254644
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58819980
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53113520
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.51304794
39CLOCK_20551151_ChIP-Seq_293T_Human1.50953822
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50450419
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49722009
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46188265
43* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45072282
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40839534
45RXRA_24833708_ChIP-Seq_LIVER_Mouse1.40687789
46* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40072230
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39575924
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36137493
49EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36080870
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.35435839
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34057462
52CJUN_26792858_Chip-Seq_BT549_Human1.33516720
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.24977959
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24879767
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.24493775
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23839028
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.22832385
58TFEB_21752829_ChIP-Seq_HELA_Human1.22048206
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21061028
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.19708675
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18067632
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.16532335
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16243250
64ZNF263_19887448_ChIP-Seq_K562_Human1.14400656
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12116633
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11356769
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.11310074
68* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11258579
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10343014
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10262033
71ATF3_27146783_Chip-Seq_COLON_Human1.10125109
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09228023
73CHD1_26751641_Chip-Seq_LNCaP_Human1.09129557
74GATA4_25053715_ChIP-Seq_YYC3_Human1.09096246
75UBF1/2_26484160_Chip-Seq_HMECs_Human1.08253253
76NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06798434
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05189799
78* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04861587
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03121924
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.02971019
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02577310
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01451682
83FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01444685
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98443656
85HTT_18923047_ChIP-ChIP_STHdh_Human0.97846745
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97214574
87TP63_23658742_ChIP-Seq_EP156T_Human0.96139730
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95861781
89ESR2_21235772_ChIP-Seq_MCF-7_Human0.95673396
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95500256
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94121951
92PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93696868
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93329715
94RARA_24833708_ChIP-Seq_LIVER_Mouse0.85806749
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85651613
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85546066
97GATA6_25053715_ChIP-Seq_YYC3_Human0.83838283
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80658050
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77580369
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77260141
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76681381
102TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76637204
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76298353
104GATA1_22025678_ChIP-Seq_K562_Human0.75583855
105KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75369324
106NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74202213
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74202213
108RARB_24833708_ChIP-Seq_LIVER_Mouse0.73520350
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72895483
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72451741
111SOX2_20726797_ChIP-Seq_SW620_Human0.71174829
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.70792652
113FOXA1_25552417_ChIP-Seq_VCAP_Human0.70606659
114* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.70420011
115PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.70093364
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69970371
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.68334512
118SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.68247055
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.68097802
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.68097802
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.68097802
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.67882364
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.66312775
124SPI1_26923725_Chip-Seq_HPCs_Mouse0.65299577
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.64516430
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.63955079
127NANOG_16518401_ChIP-PET_MESCs_Mouse0.62607667
128EZH2_27294783_Chip-Seq_NPCs_Mouse0.62398191
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.61524291
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.61340220
131GATA3_24758297_ChIP-Seq_MCF-7_Human0.60776397
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.60061896
133HIF1A_21447827_ChIP-Seq_MCF-7_Human0.59302092
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.59217651
135NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.57407512
136CRX_20693478_ChIP-Seq_RETINA_Mouse0.57266735
137NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.57218183
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.57132351
139* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.56901489
140HNFA_21074721_ChIP-Seq_CACO-2_Human0.56300994
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.55619575
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.54793625
143PCGF2_27294783_Chip-Seq_NPCs_Mouse0.54344173
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.54334693
145OCT4_21477851_ChIP-Seq_ESCs_Mouse0.54279185
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.53210253
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.52270568
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.51729182
149* CDX2_22108803_ChIP-Seq_LS180_Human0.51673534
150FOXM1_26456572_ChIP-Seq_MCF-7_Human0.51327520
151STAT1_17558387_ChIP-Seq_HELA_Human0.48776097
152ESRRB_18555785_Chip-Seq_ESCs_Mouse0.48640931
153SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.48606513
154FOXO3_23340844_ChIP-Seq_DLD1_Human0.48152010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.77574815
2MP0005360_urolithiasis7.13271416
3MP0005085_abnormal_gallbladder_physiolo6.34341627
4MP0005365_abnormal_bile_salt6.20074695
5MP0008438_abnormal_cutaneous_collagen4.66379409
6MP0008875_abnormal_xenobiotic_pharmacok4.42950641
7MP0003252_abnormal_bile_duct3.76905546
8MP0003806_abnormal_nucleotide_metabolis3.58806072
9MP0010329_abnormal_lipoprotein_level3.11818054
10MP0004272_abnormal_basement_membrane2.88683066
11MP0010234_abnormal_vibrissa_follicle2.81000730
12MP0001666_abnormal_nutrient_absorption2.78579689
13MP0003950_abnormal_plasma_membrane2.75783713
14MP0009840_abnormal_foam_cell2.73996059
15MP0003566_abnormal_cell_adhesion2.61265903
16MP0003195_calcinosis2.55404157
17MP0005275_abnormal_skin_tensile2.50940813
18MP0005332_abnormal_amino_acid2.47861929
19MP0005083_abnormal_biliary_tract2.35360194
20MP0004019_abnormal_vitamin_homeostasis2.25970286
21MP0003941_abnormal_skin_development2.22096002
22MP0000609_abnormal_liver_physiology2.08163259
23MP0003091_abnormal_cell_migration1.95128158
24MP0005076_abnormal_cell_differentiation1.91513101
25MP0002877_abnormal_melanocyte_morpholog1.88874619
26MP0003191_abnormal_cellular_cholesterol1.87932926
27MP0002118_abnormal_lipid_homeostasis1.87097902
28MP0006054_spinal_hemorrhage1.80635979
29MP0009697_abnormal_copulation1.71900475
30MP0002138_abnormal_hepatobiliary_system1.67272256
31MP0003868_abnormal_feces_composition1.66579030
32MP0005319_abnormal_enzyme/_coenzyme1.63552198
33MP0001764_abnormal_homeostasis1.62132408
34MP0003300_gastrointestinal_ulcer1.60413122
35MP0005257_abnormal_intraocular_pressure1.43138740
36MP0005409_darkened_coat_color1.42592170
37MP0004233_abnormal_muscle_weight1.35125216
38MP0005623_abnormal_meninges_morphology1.28589684
39MP0004957_abnormal_blastocyst_morpholog1.28471274
40MP0002086_abnormal_extraembryonic_tissu1.24334514
41MP0001730_embryonic_growth_arrest1.24105399
42MP0010307_abnormal_tumor_latency1.22381293
43MP0004264_abnormal_extraembryonic_tissu1.17039001
44MP0003221_abnormal_cardiomyocyte_apopto1.15788178
45MP0000013_abnormal_adipose_tissue1.15364688
46MP0003656_abnormal_erythrocyte_physiolo1.14915689
47MP0000598_abnormal_liver_morphology1.14395445
48MP0005647_abnormal_sex_gland1.14149628
49MP0002896_abnormal_bone_mineralization1.13195095
50MP0003705_abnormal_hypodermis_morpholog1.11403013
51MP0003186_abnormal_redox_activity1.10240302
52MP0008004_abnormal_stomach_pH1.10178845
53MP0009643_abnormal_urine_homeostasis1.09733224
54MP0003984_embryonic_growth_retardation1.09433197
55MP0005451_abnormal_body_composition1.09247117
56MP0001672_abnormal_embryogenesis/_devel1.09011234
57MP0005380_embryogenesis_phenotype1.09011234
58MP0000003_abnormal_adipose_tissue1.08421698
59MP0002088_abnormal_embryonic_growth/wei1.06712166
60MP0000767_abnormal_smooth_muscle1.06558101
61MP0005084_abnormal_gallbladder_morpholo1.01519641
62MP0005220_abnormal_exocrine_pancreas1.01491367
63MP0005621_abnormal_cell_physiology1.01426776
64MP0005584_abnormal_enzyme/coenzyme_acti1.01373456
65MP0003693_abnormal_embryo_hatching0.97733719
66MP0009764_decreased_sensitivity_to0.96460418
67MP0001216_abnormal_epidermal_layer0.96192024
68MP0000350_abnormal_cell_proliferation0.95274871
69MP0008057_abnormal_DNA_replication0.94794561
70MP0002006_tumorigenesis0.94461301
71MP0002166_altered_tumor_susceptibility0.93838041
72MP0003279_aneurysm0.93548052
73MP0003890_abnormal_embryonic-extraembry0.91029969
74MP0001697_abnormal_embryo_size0.90784031
75MP0009053_abnormal_anal_canal0.90555339
76MP0003111_abnormal_nucleus_morphology0.89877008
77MP0005503_abnormal_tendon_morphology0.88190137
78MP0002009_preneoplasia0.87873017
79MP0005248_abnormal_Harderian_gland0.86766741
80MP0002089_abnormal_postnatal_growth/wei0.85636756
81MP0009763_increased_sensitivity_to0.85256583
82MP0003718_maternal_effect0.84894743
83MP0005501_abnormal_skin_physiology0.83571066
84MP0005375_adipose_tissue_phenotype0.83548670
85MP0008932_abnormal_embryonic_tissue0.82729790
86MP0005376_homeostasis/metabolism_phenot0.80859792
87MP0002060_abnormal_skin_morphology0.80240820
88MP0005408_hypopigmentation0.78528308
89MP0005395_other_phenotype0.77976044
90MP0002254_reproductive_system_inflammat0.77636363
91MP0000579_abnormal_nail_morphology0.77412158
92MP0003453_abnormal_keratinocyte_physiol0.76965707
93MP0010678_abnormal_skin_adnexa0.76330396
94MP0002084_abnormal_developmental_patter0.76057277
95MP0002876_abnormal_thyroid_physiology0.75531672
96MP0009765_abnormal_xenobiotic_induced0.74631712
97MP0003077_abnormal_cell_cycle0.74171118
98MP0005384_cellular_phenotype0.73921402
99MP0008469_abnormal_protein_level0.73497382
100MP0001881_abnormal_mammary_gland0.73012634
101MP0009780_abnormal_chondrocyte_physiolo0.72183738
102MP0000639_abnormal_adrenal_gland0.72035205
103MP0009642_abnormal_blood_homeostasis0.71838269
104MP0002080_prenatal_lethality0.71821872
105MP0002971_abnormal_brown_adipose0.71774971
106MP0004197_abnormal_fetal_growth/weight/0.71340204
107MP0000627_abnormal_mammary_gland0.71279884
108MP0002078_abnormal_glucose_homeostasis0.69891481
109MP0001958_emphysema0.69860131
110MP0001879_abnormal_lymphatic_vessel0.68696739
111MP0003385_abnormal_body_wall0.68688966
112MP0000858_altered_metastatic_potential0.68659750
113MP0005334_abnormal_fat_pad0.67836581
114MP0005666_abnormal_adipose_tissue0.66982580
115MP0005266_abnormal_metabolism0.66446144
116MP0005197_abnormal_uvea_morphology0.66438597
117MP0000377_abnormal_hair_follicle0.66267443
118MP0010368_abnormal_lymphatic_system0.65940729
119MP0003183_abnormal_peptide_metabolism0.65802782
120MP0004134_abnormal_chest_morphology0.65392152
121MP0002282_abnormal_trachea_morphology0.65054615
122MP0003011_delayed_dark_adaptation0.63984073
123MP0005448_abnormal_energy_balance0.63936655
124MP0005670_abnormal_white_adipose0.63504638
125MP0002796_impaired_skin_barrier0.62262107
126MP0009278_abnormal_bone_marrow0.62199496
127MP0004782_abnormal_surfactant_physiolog0.61198679
128MP0006082_CNS_inflammation0.60640932
129MP0001661_extended_life_span0.60384796
130MP0003436_decreased_susceptibility_to0.60360302
131MP0005636_abnormal_mineral_homeostasis0.59463447
132MP0009384_cardiac_valve_regurgitation0.59105065
133MP0002928_abnormal_bile_duct0.57382002
134MP0005023_abnormal_wound_healing0.55717872
135MP0002168_other_aberrant_phenotype0.55258094
136MP0001756_abnormal_urination0.55000166
137MP0002136_abnormal_kidney_physiology0.51012055
138MP0009115_abnormal_fat_cell0.50892527
139MP0008995_early_reproductive_senescence0.49881943
140MP0002249_abnormal_larynx_morphology0.49085743
141MP0000566_synostosis0.47987406
142MP0001243_abnormal_dermal_layer0.45884791
143MP0002933_joint_inflammation0.41187588
144MP0001542_abnormal_bone_strength0.41089390
145MP0005464_abnormal_platelet_physiology0.40738503
146MP0000163_abnormal_cartilage_morphology0.40001922
147MP0000538_abnormal_urinary_bladder0.39171923
148MP0010030_abnormal_orbit_morphology0.38576517
149MP0001340_abnormal_eyelid_morphology0.37219877
150MP0010352_gastrointestinal_tract_polyps0.37144166
151MP0003953_abnormal_hormone_level0.36983362
152MP0002970_abnormal_white_adipose0.35250021
153MP0000613_abnormal_salivary_gland0.35212688
154MP0005164_abnormal_response_to0.34417910
155MP0002115_abnormal_skeleton_extremities0.34356306
156MP0000604_amyloidosis0.33580870
157MP0003638_abnormal_response/metabolism_0.33569403
158MP0003943_abnormal_hepatobiliary_system0.33154935
159MP0001915_intracranial_hemorrhage0.32739194
160MP0000371_diluted_coat_color0.32495169
161MP0000462_abnormal_digestive_system0.32266971
162MP0001845_abnormal_inflammatory_respons0.32254355

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.89156317
2Hypobetalipoproteinemia (HP:0003563)6.43269883
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.39154717
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.99095050
5Prolonged partial thromboplastin time (HP:0003645)5.93590102
6Deep venous thrombosis (HP:0002625)5.90579655
7Xanthomatosis (HP:0000991)5.63579576
8Hypolipoproteinemia (HP:0010981)4.68378402
9Complement deficiency (HP:0004431)4.51104704
10Fat malabsorption (HP:0002630)4.46277287
11Conjugated hyperbilirubinemia (HP:0002908)4.37676737
12Abnormality of the common coagulation pathway (HP:0010990)4.30572659
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.30194541
14Premature rupture of membranes (HP:0001788)4.23313996
15Epidermoid cyst (HP:0200040)4.22091121
16Hypoglycemic coma (HP:0001325)4.20192748
17Hyperlipoproteinemia (HP:0010980)4.19102854
18Joint hemorrhage (HP:0005261)4.16614536
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.13935393
20Hypochromic microcytic anemia (HP:0004840)3.96566215
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.89726614
22Hypoalphalipoproteinemia (HP:0003233)3.79996904
23Abnormality of the intrinsic pathway (HP:0010989)3.76605130
24Abnormality of methionine metabolism (HP:0010901)3.74714705
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.69696819
26Hyperammonemia (HP:0001987)3.63709408
27Abnormality of pyrimidine metabolism (HP:0004353)3.60248778
28Protrusio acetabuli (HP:0003179)3.52913731
29Myocardial infarction (HP:0001658)3.52611718
30Hyperglycinemia (HP:0002154)3.46754368
31Abnormality of complement system (HP:0005339)3.46100096
32Ketosis (HP:0001946)3.45590491
33Hyperglycinuria (HP:0003108)3.41131431
34Hypoglycemic seizures (HP:0002173)3.32122372
35Hypercholesterolemia (HP:0003124)3.24558241
36Steatorrhea (HP:0002570)3.19176769
37Papillary thyroid carcinoma (HP:0002895)3.13847178
38Abnormality of serine family amino acid metabolism (HP:0010894)3.07119416
39Abnormality of glycine metabolism (HP:0010895)3.07119416
40Follicular hyperkeratosis (HP:0007502)3.05172944
41Arterial tortuosity (HP:0005116)3.03255468
42Vascular tortuosity (HP:0004948)2.94696120
43Aortic dissection (HP:0002647)2.91152922
44Abnormality of nucleobase metabolism (HP:0010932)2.84308181
45Hyperbilirubinemia (HP:0002904)2.81748074
46Ketoacidosis (HP:0001993)2.70617435
47Abnormal tarsal ossification (HP:0008369)2.66856384
48Vitreoretinal degeneration (HP:0000655)2.65081100
49Hepatocellular carcinoma (HP:0001402)2.60512271
50Wormian bones (HP:0002645)2.60076768
51Pancreatic islet-cell hyperplasia (HP:0004510)2.59678041
52Turricephaly (HP:0000262)2.59129470
53Hyperglycemia (HP:0003074)2.58990077
54Abnormality of proline metabolism (HP:0010907)2.58500815
55Hydroxyprolinuria (HP:0003080)2.58500815
56Symptomatic seizures (HP:0011145)2.56045426
57Hyperinsulinemic hypoglycemia (HP:0000825)2.51152531
58Asymmetry of the thorax (HP:0001555)2.50210593
59Flat acetabular roof (HP:0003180)2.49495183
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.49373837
61Alopecia of scalp (HP:0002293)2.49049542
62Malnutrition (HP:0004395)2.48948059
63Acanthocytosis (HP:0001927)2.48068961
64Overlapping toe (HP:0001845)2.47276868
65Abnormality of purine metabolism (HP:0004352)2.46337883
66Tetraparesis (HP:0002273)2.45237397
67Skin nodule (HP:0200036)2.42684513
68Abnormality of fatty-acid metabolism (HP:0004359)2.42178515
69Abnormality of carpal bone ossification (HP:0006257)2.41334709
70Ankle contracture (HP:0006466)2.39696675
71Abnormality of serum amino acid levels (HP:0003112)2.39242595
72Spontaneous abortion (HP:0005268)2.35913560
73Aortic aneurysm (HP:0004942)2.34227592
74Systemic lupus erythematosus (HP:0002725)2.33419569
75Abnormal delivery (HP:0001787)2.30507104
76Atrophic scars (HP:0001075)2.28922788
77Abnormality of the ischium (HP:0003174)2.27250958
78Renal cortical cysts (HP:0000803)2.27093639
79Vascular calcification (HP:0004934)2.24918195
80Enlarged kidneys (HP:0000105)2.23048762
81Abnormality of endocrine pancreas physiology (HP:0012093)2.21552904
82Abnormality of the pancreatic islet cells (HP:0006476)2.21552904
83Soft skin (HP:0000977)2.20968988
84Abnormal enzyme/coenzyme activity (HP:0012379)2.20524525
85Hypoplastic ischia (HP:0003175)2.18751587
86Abnormal gallbladder physiology (HP:0012438)2.18328747
87Cholecystitis (HP:0001082)2.18328747
88Mitral valve prolapse (HP:0001634)2.17652867
89Dilatation of the ascending aorta (HP:0005111)2.14102787
90Ankyloglossia (HP:0010296)2.13890120
91Metabolic acidosis (HP:0001942)2.11332403
92Sensorimotor neuropathy (HP:0007141)2.11166491
93Proximal tubulopathy (HP:0000114)2.10799654
94Delayed CNS myelination (HP:0002188)2.10432438
95Glomerulonephritis (HP:0000099)2.10068977
96Cupped ribs (HP:0000887)2.09754096
97Menorrhagia (HP:0000132)2.09392719
98Recurrent gram-negative bacterial infections (HP:0005420)2.08545982
99Cervical subluxation (HP:0003308)2.06638200
100Cortical dysplasia (HP:0002539)2.06305882
101Cardiovascular calcification (HP:0011915)2.05579377
102Curly hair (HP:0002212)2.03674197
103Esophageal varix (HP:0002040)2.03670946
104Abnormality of alkaline phosphatase activity (HP:0004379)2.01742498
105Opisthotonus (HP:0002179)1.99803339
106Abnormal cartilage morphology (HP:0002763)1.99260537
107Abnormal foot bone ossification (HP:0010675)1.98901780
108Osteomalacia (HP:0002749)1.98840286
109Neonatal short-limb short stature (HP:0008921)1.98585850
110Rickets (HP:0002748)1.98253061
111Right ventricular cardiomyopathy (HP:0011663)1.98073478
112Blue sclerae (HP:0000592)1.97726610
113Abnormality of dentin (HP:0010299)1.97251348
114Protuberant abdomen (HP:0001538)1.96512036
115Pancreatitis (HP:0001733)1.95788376
116Osteolytic defects of the hand bones (HP:0009699)1.95113940
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.95113940
118Abnormal ossification of hand bones (HP:0005921)1.94582696
119Irritability (HP:0000737)1.93976463
120Mitral stenosis (HP:0001718)1.93963556
121Lethargy (HP:0001254)1.93855482
122Thin bony cortex (HP:0002753)1.93648634
123Acute hepatic failure (HP:0006554)1.93606890
124Relative macrocephaly (HP:0004482)1.93258560
125Thyroid carcinoma (HP:0002890)1.92834012
126Spondylolisthesis (HP:0003302)1.91156988
127Small epiphyses (HP:0010585)1.89308252
128Abnormal hand bone ossification (HP:0010660)1.89236358
129Gingival bleeding (HP:0000225)1.84649756
130Abnormality of the acetabulum (HP:0003170)1.84229909
131Hyperextensible skin (HP:0000974)1.84221008
132Generalized aminoaciduria (HP:0002909)1.83804280
133Abnormality of oral frenula (HP:0000190)1.82822730
134Pustule (HP:0200039)1.82810031
135Epiphyseal dysplasia (HP:0002656)1.82489453
136Abnormal gallbladder morphology (HP:0012437)1.81693247
137Increased mean platelet volume (HP:0011877)1.81073178
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79773119
139Bladder diverticulum (HP:0000015)1.78219193
140Syringomyelia (HP:0003396)1.78186343
141Spinal cord lesions (HP:0100561)1.78186343
142Ileus (HP:0002595)1.77266791
143Hypophosphatemic rickets (HP:0004912)1.77118490
144Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76308848
145Dicarboxylic aciduria (HP:0003215)1.76308848
146Heterotopia (HP:0002282)1.75613126
147Vertebral compression fractures (HP:0002953)1.75593022
148Insidious onset (HP:0003587)1.75481236
149Termporal pattern (HP:0011008)1.75481236
150Sparse lateral eyebrow (HP:0005338)1.75302852
151Elevated alkaline phosphatase (HP:0003155)1.75201532
152Disproportionate tall stature (HP:0001519)1.74658204
153Pigmentary retinal degeneration (HP:0001146)1.72674754
154Joint laxity (HP:0001388)1.72390693
155Advanced eruption of teeth (HP:0006288)1.70080657
156Bilateral sensorineural hearing impairment (HP:0008619)1.68923518
157Aneurysm (HP:0002617)1.68648696
158Fragile skin (HP:0001030)1.68014231
159Abnormality of glycolysis (HP:0004366)1.67570764
160Broad palm (HP:0001169)1.66963316
161Microglossia (HP:0000171)1.65975549
162Coarse hair (HP:0002208)1.64516917
163Deep philtrum (HP:0002002)1.64202213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.76510530
2MAPK153.54322679
3PINK13.14584195
4BCKDK3.13188196
5DDR22.95516060
6ERN12.86490658
7SIK12.76956219
8LATS12.73932580
9MAP3K62.65873369
10ICK2.57464616
11AKT32.57053396
12FRK2.56344364
13FGFR42.41603522
14STK38L2.39528645
15ERBB42.15133296
16TAOK32.09518564
17IRAK32.07563089
18MAP3K141.95742580
19CSK1.80888170
20KSR21.80166428
21MAP3K21.78969780
22MAP3K91.77683196
23EIF2AK11.61393026
24TTK1.58659682
25SCYL21.56549003
26PRPF4B1.53173326
27MAP3K31.52287219
28MAP3K111.52216537
29EEF2K1.44402734
30CDK61.31783940
31YES11.31398146
32PKN21.30728551
33STK31.28284802
34DYRK1B1.24880377
35NUAK11.23185375
36GSK3A1.21332356
37EPHA21.18520411
38ACVR1B1.18317219
39RIPK11.18000277
40MST1R1.16947668
41PIK3CG1.16594338
42WNK11.16284809
43MAPK111.14765372
44PDK21.14562694
45MAPK71.14020154
46PIM11.13655087
47TRPM71.11963665
48NEK11.10194707
49EPHA31.09367627
50SMG11.07450189
51FGFR11.07323667
52PDGFRB1.07012870
53BMX1.03856629
54PIM21.03321253
55CHUK1.02571152
56KSR11.01753311
57NLK0.98477348
58ZAK0.98101214
59TYK20.94964336
60PRKAA20.94217273
61CLK10.94143719
62CDK90.93709009
63MATK0.90328560
64PDGFRA0.89931982
65NEK90.88588733
66CAMK1G0.86976624
67SIK30.84763748
68BRSK20.84534555
69CDK120.84522582
70PRKAA10.83580024
71MTOR0.79540450
72TGFBR20.78228400
73MAP3K130.77796191
74PIK3CA0.76240167
75LATS20.75703267
76PAK20.75271994
77MAP3K80.75157917
78TSSK60.72727882
79STK390.72472477
80TAOK20.72366637
81ABL20.70497504
82IKBKB0.69675900
83MST40.68870893
84JAK10.68202855
85GRK10.68025339
86MET0.67849937
87NEK60.66888449
88ERBB20.66792329
89PRKD20.66335003
90JAK20.65356745
91FLT30.65226873
92CDK70.65115171
93RET0.64881289
94TRIB30.63328088
95LMTK20.63036635
96PLK40.62390220
97PTK20.62050863
98PTK60.61956218
99RAF10.61796083
100FGR0.61766166
101PAK40.61656732
102BRAF0.59977654
103BRD40.57927804
104MAPK40.57212885
105FER0.55394509
106BMPR20.54976101
107ARAF0.53853493
108FGFR30.52223009
109RPS6KC10.51923253
110RPS6KL10.51923253
111TYRO30.51407952
112RPS6KB10.51097017
113MAP3K50.49966139
114PRKCZ0.49754987
115CAMK1D0.49417976
116RPS6KA60.48794416
117MAP3K120.48667457
118EIF2AK30.47134836
119SRPK10.46976809
120TAF10.46971043
121MAPK30.46842984
122CHEK10.46365954
123SGK30.46007499
124ERBB30.44905248
125AKT20.44880866
126EIF2AK20.44817360
127STK240.44634301
128IRAK10.44220053
129CDK80.43958715
130ABL10.43240014
131PLK30.43094863
132SGK20.43041376
133CDC42BPA0.42618432
134TBK10.42046507
135EPHB10.41669090
136MELK0.41076008
137PRKACG0.40839950
138IRAK40.40648919
139BCR0.40633664
140EGFR0.40396133
141MAPK10.39487576
142FGFR20.38065168
143PRKG20.36225191
144MAP3K10.35996620
145MAP2K40.35306774
146MAP3K100.33195793
147TTN0.32583959
148ATM0.32459003
149PBK0.32237856
150JAK30.30784799
151TXK0.30590726

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.22855619
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30115669
3Arginine biosynthesis_Homo sapiens_hsa002202.94466561
4Nitrogen metabolism_Homo sapiens_hsa009102.91762745
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75492524
6Tryptophan metabolism_Homo sapiens_hsa003802.74274677
7Complement and coagulation cascades_Homo sapiens_hsa046102.67922022
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.57582570
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40687211
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34017219
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20140044
12Fatty acid degradation_Homo sapiens_hsa000712.17100597
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12123503
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.10679259
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07442629
16Peroxisome_Homo sapiens_hsa041461.99665793
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.99116054
18Fatty acid metabolism_Homo sapiens_hsa012121.89244206
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.89223569
20Histidine metabolism_Homo sapiens_hsa003401.88888563
21Chemical carcinogenesis_Homo sapiens_hsa052041.85031022
22Caffeine metabolism_Homo sapiens_hsa002321.84599316
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84157194
24Selenocompound metabolism_Homo sapiens_hsa004501.77992264
25Butanoate metabolism_Homo sapiens_hsa006501.74628400
26PPAR signaling pathway_Homo sapiens_hsa033201.70569337
27Folate biosynthesis_Homo sapiens_hsa007901.69857657
28Retinol metabolism_Homo sapiens_hsa008301.69828377
29Starch and sucrose metabolism_Homo sapiens_hsa005001.69431710
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.67863374
31Sulfur metabolism_Homo sapiens_hsa009201.66822965
32Staphylococcus aureus infection_Homo sapiens_hsa051501.66416632
33beta-Alanine metabolism_Homo sapiens_hsa004101.64804649
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61472230
35Thyroid cancer_Homo sapiens_hsa052161.59456592
36Propanoate metabolism_Homo sapiens_hsa006401.59318061
37Fat digestion and absorption_Homo sapiens_hsa049751.53107649
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50029817
39Phenylalanine metabolism_Homo sapiens_hsa003601.47731483
40Steroid biosynthesis_Homo sapiens_hsa001001.46629814
41ABC transporters_Homo sapiens_hsa020101.38731876
42Fatty acid elongation_Homo sapiens_hsa000621.38480798
43Small cell lung cancer_Homo sapiens_hsa052221.32853259
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31714152
45Fatty acid biosynthesis_Homo sapiens_hsa000611.30483782
46Bile secretion_Homo sapiens_hsa049761.29337798
47Vitamin digestion and absorption_Homo sapiens_hsa049771.28724172
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27986112
49Chronic myeloid leukemia_Homo sapiens_hsa052201.27895587
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27734609
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.27711934
52Lysine degradation_Homo sapiens_hsa003101.27492335
53ECM-receptor interaction_Homo sapiens_hsa045121.27229998
54Tyrosine metabolism_Homo sapiens_hsa003501.26488513
55Arginine and proline metabolism_Homo sapiens_hsa003301.26302365
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18754419
57Proteoglycans in cancer_Homo sapiens_hsa052051.17586583
58Prostate cancer_Homo sapiens_hsa052151.17339092
59Pancreatic cancer_Homo sapiens_hsa052121.14309004
60Bladder cancer_Homo sapiens_hsa052191.13948954
61MicroRNAs in cancer_Homo sapiens_hsa052061.10568460
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10429619
63Focal adhesion_Homo sapiens_hsa045101.07592162
64Amoebiasis_Homo sapiens_hsa051461.05375782
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04621972
66p53 signaling pathway_Homo sapiens_hsa041151.03544902
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00020565
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.99944599
69Biosynthesis of amino acids_Homo sapiens_hsa012300.98925702
70Pyruvate metabolism_Homo sapiens_hsa006200.98297416
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97317622
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96315313
73Renal cell carcinoma_Homo sapiens_hsa052110.96199596
74N-Glycan biosynthesis_Homo sapiens_hsa005100.94917457
75One carbon pool by folate_Homo sapiens_hsa006700.92559827
76Vitamin B6 metabolism_Homo sapiens_hsa007500.90599141
77Hepatitis B_Homo sapiens_hsa051610.89855463
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81751612
79TNF signaling pathway_Homo sapiens_hsa046680.81144050
80Endometrial cancer_Homo sapiens_hsa052130.80691309
81Glutathione metabolism_Homo sapiens_hsa004800.79812879
82Non-small cell lung cancer_Homo sapiens_hsa052230.78792281
83HIF-1 signaling pathway_Homo sapiens_hsa040660.75743231
84Viral carcinogenesis_Homo sapiens_hsa052030.74450744
85Sulfur relay system_Homo sapiens_hsa041220.72437762
86Carbon metabolism_Homo sapiens_hsa012000.72200714
87Prolactin signaling pathway_Homo sapiens_hsa049170.70109194
88Influenza A_Homo sapiens_hsa051640.69934751
89Cell cycle_Homo sapiens_hsa041100.68296910
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66112744
91Glycerolipid metabolism_Homo sapiens_hsa005610.65869152
92Acute myeloid leukemia_Homo sapiens_hsa052210.65489483
93Galactose metabolism_Homo sapiens_hsa000520.65140211
94Other glycan degradation_Homo sapiens_hsa005110.64254654
95Shigellosis_Homo sapiens_hsa051310.62826331
96Thyroid hormone synthesis_Homo sapiens_hsa049180.62527982
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61448007
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.59816541
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57930507
100FoxO signaling pathway_Homo sapiens_hsa040680.56718723
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54953854
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54798080
103Vibrio cholerae infection_Homo sapiens_hsa051100.54092221
104Melanoma_Homo sapiens_hsa052180.52197104
105African trypanosomiasis_Homo sapiens_hsa051430.48962573
106mTOR signaling pathway_Homo sapiens_hsa041500.48839621
107mRNA surveillance pathway_Homo sapiens_hsa030150.48023284
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46099191
109Apoptosis_Homo sapiens_hsa042100.46005583
110Measles_Homo sapiens_hsa051620.45096969
111Metabolic pathways_Homo sapiens_hsa011000.44584732
112ErbB signaling pathway_Homo sapiens_hsa040120.44374519
113Fructose and mannose metabolism_Homo sapiens_hsa000510.43624910
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32024510
115Prion diseases_Homo sapiens_hsa050200.28087679
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27153435
117Insulin resistance_Homo sapiens_hsa049310.25778003
118Pentose phosphate pathway_Homo sapiens_hsa000300.25038782
119Renin-angiotensin system_Homo sapiens_hsa046140.23732581
120Linoleic acid metabolism_Homo sapiens_hsa005910.23040433
121Circadian rhythm_Homo sapiens_hsa047100.20720227
122Protein digestion and absorption_Homo sapiens_hsa049740.17979117
123* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16808461
124Mineral absorption_Homo sapiens_hsa049780.16182531
125Adherens junction_Homo sapiens_hsa045200.10275861
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.09048229
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.07937259
128AMPK signaling pathway_Homo sapiens_hsa041520.07848978
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06542430
130TGF-beta signaling pathway_Homo sapiens_hsa043500.06155278
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.04952385
132Glucagon signaling pathway_Homo sapiens_hsa049220.03136538
133Arachidonic acid metabolism_Homo sapiens_hsa005900.02666583
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.01130468
135Hepatitis C_Homo sapiens_hsa05160-0.0921971
136Insulin signaling pathway_Homo sapiens_hsa04910-0.0894630
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0885917
138Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0860997
139Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0820663
140NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0761109
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0404579
142Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0301405
143Protein export_Homo sapiens_hsa03060-0.0184621
144Legionellosis_Homo sapiens_hsa05134-0.0168775
145Sphingolipid metabolism_Homo sapiens_hsa00600-0.0080948

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