SEC24B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of RNA export from nucleus (GO:0046831)4.28214376
2histone H3-K36 demethylation (GO:0070544)4.18239389
3histone H3-K9 demethylation (GO:0033169)4.18173734
4interleukin-6-mediated signaling pathway (GO:0070102)3.90627953
5nuclear pore organization (GO:0006999)3.90414979
6interkinetic nuclear migration (GO:0022027)3.87384529
7positive regulation of gamma-delta T cell activation (GO:0046645)3.85137119
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79672323
9nuclear pore complex assembly (GO:0051292)3.66323602
10definitive hemopoiesis (GO:0060216)3.64233867
11regulation of interleukin-12 biosynthetic process (GO:0045075)3.49559211
12regulation of nucleobase-containing compound transport (GO:0032239)3.48915307
13histone lysine demethylation (GO:0070076)3.46301799
14monoubiquitinated protein deubiquitination (GO:0035520)3.43529712
15embryonic process involved in female pregnancy (GO:0060136)3.40667904
16peptidyl-lysine trimethylation (GO:0018023)3.35572786
17cellular response to ethanol (GO:0071361)3.35356029
18* COPII vesicle coating (GO:0048208)3.31379068
19histone demethylation (GO:0016577)3.30127658
20phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.27873491
21microtubule anchoring (GO:0034453)3.24054023
22neural tube formation (GO:0001841)3.19141103
23Golgi to endosome transport (GO:0006895)3.16956070
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13459568
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13459568
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.11371466
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.11371466
28modulation by symbiont of host immune response (GO:0052553)3.11371466
29positive regulation by symbiont of host defense response (GO:0052509)3.11371466
30modulation by symbiont of host defense response (GO:0052031)3.11371466
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.11371466
32antigen processing and presentation of endogenous antigen (GO:0019883)2.98219715
33regulation of gamma-delta T cell differentiation (GO:0045586)2.97004326
34establishment of protein localization to Golgi (GO:0072600)2.95734094
35positive regulation of histone deacetylation (GO:0031065)2.92387688
36protein targeting to Golgi (GO:0000042)2.92154654
37regulation of gamma-delta T cell activation (GO:0046643)2.89852965
38regulation of fibroblast apoptotic process (GO:2000269)2.89459943
39retrograde transport, vesicle recycling within Golgi (GO:0000301)2.87918331
40nucleus localization (GO:0051647)2.86087029
41energy homeostasis (GO:0097009)2.83984211
42protein dealkylation (GO:0008214)2.82339616
43protein demethylation (GO:0006482)2.82339616
44early endosome to late endosome transport (GO:0045022)2.81850682
45dosage compensation (GO:0007549)2.81257959
46NLS-bearing protein import into nucleus (GO:0006607)2.80429532
47regulation of interferon-beta biosynthetic process (GO:0045357)2.80274493
48histone H2B ubiquitination (GO:0033523)2.79404600
49regulation of NFAT protein import into nucleus (GO:0051532)2.79148721
50blood vessel maturation (GO:0001955)2.78722782
51negative regulation of cell killing (GO:0031342)2.77357951
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.77357951
53protein targeting to vacuole (GO:0006623)2.76856005
54protein targeting to lysosome (GO:0006622)2.76856005
55establishment of protein localization to vacuole (GO:0072666)2.76856005
56cell wall macromolecule catabolic process (GO:0016998)2.75692702
57morphogenesis of an epithelial sheet (GO:0002011)2.68067098
58protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.66985785
59negative regulation of NF-kappaB import into nucleus (GO:0042347)2.66370636
60histone H3-K4 methylation (GO:0051568)2.65550953
61negative regulation of neurotransmitter secretion (GO:0046929)2.64563597
62protein K11-linked deubiquitination (GO:0035871)2.61994677
63cytoplasmic mRNA processing body assembly (GO:0033962)2.61032416
64peptidyl-lysine methylation (GO:0018022)2.60368296
65cellular response to fluid shear stress (GO:0071498)2.60263834
66regulation of chemokine-mediated signaling pathway (GO:0070099)2.60099493
67histone H3-K9 modification (GO:0061647)2.59798859
68histone H3-K9 methylation (GO:0051567)2.59672525
69negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.59162473
70negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.58805850
71regulation of transforming growth factor beta2 production (GO:0032909)2.58608127
72poly(A)+ mRNA export from nucleus (GO:0016973)2.57855921
73JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.55852351
74negative regulation of anoikis (GO:2000811)2.55768161
75protein K48-linked deubiquitination (GO:0071108)2.54293272
76tolerance induction (GO:0002507)2.53893176
77COPI coating of Golgi vesicle (GO:0048205)2.53326997
78Golgi transport vesicle coating (GO:0048200)2.53326997
79protein K63-linked deubiquitination (GO:0070536)2.52988989
80pathway-restricted SMAD protein phosphorylation (GO:0060389)2.52374169
81positive regulation of natural killer cell differentiation (GO:0032825)2.49343543
82positive regulation of granulocyte differentiation (GO:0030854)2.48572792
83negative regulation of fibroblast apoptotic process (GO:2000270)2.48259796
84positive regulation of mitochondrial fission (GO:0090141)2.47806111
85positive regulation of T cell cytokine production (GO:0002726)2.42933671
86response to muramyl dipeptide (GO:0032495)2.41560285
87cell adhesion mediated by integrin (GO:0033627)2.40709703
88establishment of nucleus localization (GO:0040023)2.40524964
89genitalia morphogenesis (GO:0035112)2.40451550
90pore complex assembly (GO:0046931)2.39460215
91histone lysine methylation (GO:0034968)2.38761682
92response to type I interferon (GO:0034340)2.37966169
93embryonic camera-type eye morphogenesis (GO:0048596)2.37465968
94neuronal stem cell maintenance (GO:0097150)2.37318147
95myeloid dendritic cell differentiation (GO:0043011)2.35988926
96positive regulation of mRNA 3-end processing (GO:0031442)2.35894713
97regulation of pigment cell differentiation (GO:0050932)2.34784918
98regulation of T-helper 1 cell differentiation (GO:0045625)2.33843377
99type I interferon signaling pathway (GO:0060337)2.33696862
100cellular response to type I interferon (GO:0071357)2.33696862
101intra-Golgi vesicle-mediated transport (GO:0006891)2.33578490
102histone H3-K4 trimethylation (GO:0080182)2.32271404
103macrophage activation involved in immune response (GO:0002281)2.29518856
104germinal center formation (GO:0002467)2.28578175
105endoplasmic reticulum organization (GO:0007029)2.28025741
106platelet-derived growth factor receptor signaling pathway (GO:0048008)2.27253209
107protein targeting to plasma membrane (GO:0072661)2.26766114
108positive regulation of macroautophagy (GO:0016239)2.24725535
109regulation of sarcomere organization (GO:0060297)2.24124888
110nerve growth factor signaling pathway (GO:0038180)2.24064811
111* vesicle coating (GO:0006901)2.23224825
112histone monoubiquitination (GO:0010390)2.22805740
113negative regulation of potassium ion transmembrane transport (GO:1901380)2.22240367
114hypotonic response (GO:0006971)2.22095186
115pre-miRNA processing (GO:0031054)2.21958064
116negative regulation of complement activation (GO:0045916)2.21248301
117positive regulation of lamellipodium assembly (GO:0010592)2.21136097
118regulation of T cell tolerance induction (GO:0002664)2.21047638
119regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.20018931
120positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.20018931
121negative thymic T cell selection (GO:0045060)2.19837765
122regulation of alkaline phosphatase activity (GO:0010692)2.19375169
123negative T cell selection (GO:0043383)2.19356384
124androgen receptor signaling pathway (GO:0030521)2.19319431
125fibroblast migration (GO:0010761)2.19255469
126glucocorticoid receptor signaling pathway (GO:0042921)2.19112571
127negative regulation of T-helper cell differentiation (GO:0045623)2.19058469
128negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.19058469
129growth hormone receptor signaling pathway (GO:0060396)2.18909966
130positive regulation of interferon-alpha production (GO:0032727)2.17847144
131Notch signaling involved in heart development (GO:0061314)2.17608628
132peptidyl-threonine modification (GO:0018210)2.17464618
133lipopolysaccharide-mediated signaling pathway (GO:0031663)2.17059725
134negative regulation of vascular permeability (GO:0043116)2.16593473
135positive regulation of chemokine biosynthetic process (GO:0045080)2.15975344
136keratinocyte differentiation (GO:0030216)2.15796436
137positive regulation of tolerance induction (GO:0002645)2.15763265
138negative regulation of granulocyte differentiation (GO:0030853)2.15391981
139substrate-dependent cell migration (GO:0006929)2.15074279
140positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.14469210
141regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.14469210
142interferon-gamma production (GO:0032609)2.13477338
143peptidyl-threonine phosphorylation (GO:0018107)2.12881972
144response to interferon-alpha (GO:0035455)2.12390773
145regulation of interferon-alpha production (GO:0032647)2.12234901
146interferon-gamma-mediated signaling pathway (GO:0060333)2.12080290
147regulation of macrophage cytokine production (GO:0010935)2.11352108
148positive thymic T cell selection (GO:0045059)2.11074809
149hemidesmosome assembly (GO:0031581)2.11007688
150nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.09898608
151cellular response to interferon-alpha (GO:0035457)2.09863039
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.09535992
153corticosteroid receptor signaling pathway (GO:0031958)2.09335556
154response to laminar fluid shear stress (GO:0034616)2.09289363
155N-terminal protein amino acid acetylation (GO:0006474)2.09089425
156mitotic sister chromatid cohesion (GO:0007064)2.08704115
157positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.08700639
158regulation of anoikis (GO:2000209)2.08472538
159positive regulation of developmental pigmentation (GO:0048087)2.07879623
160Arp2/3 complex-mediated actin nucleation (GO:0034314)2.07813078
161glial cell migration (GO:0008347)2.06984190
162regulation of type I interferon-mediated signaling pathway (GO:0060338)2.06433853
163cerebral cortex cell migration (GO:0021795)2.06382449
164leukocyte cell-cell adhesion (GO:0007159)2.04644786
165axon extension involved in axon guidance (GO:0048846)2.03320666
166neuron projection extension involved in neuron projection guidance (GO:1902284)2.03320666
167negative regulation of smooth muscle cell migration (GO:0014912)2.02322823
168T cell migration (GO:0072678)2.02078736
169positive regulation of protein deacetylation (GO:0090312)2.02025064
170positive regulation of epithelial to mesenchymal transition (GO:0010718)2.01733280
171leukocyte aggregation (GO:0070486)2.00806250
172positive regulation of mRNA catabolic process (GO:0061014)2.00356068
173positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.00276743
174T cell proliferation (GO:0042098)1.99253544
175I-kappaB phosphorylation (GO:0007252)1.99189240
176positive regulation of interferon-gamma biosynthetic process (GO:0045078)1.98529736
177regulation of tolerance induction (GO:0002643)1.98222890
178hippo signaling (GO:0035329)1.97759988
179natural killer cell differentiation (GO:0001779)1.96832514
180cortical actin cytoskeleton organization (GO:0030866)1.96196534
181positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003601.96189863
182positive regulation of interleukin-2 production (GO:0032743)1.95862662
183semaphorin-plexin signaling pathway (GO:0071526)1.95611684
184myeloid dendritic cell activation (GO:0001773)1.94990897
185positive regulation of lamellipodium organization (GO:1902745)1.94038961
186response to host (GO:0075136)1.93943190
187response to host defenses (GO:0052200)1.93943190
188response to defenses of other organism involved in symbiotic interaction (GO:0052173)1.93943190
189positive regulation of blood vessel endothelial cell migration (GO:0043536)1.91495658
190positive regulation of interleukin-2 biosynthetic process (GO:0045086)1.90972577
191cellular response to exogenous dsRNA (GO:0071360)1.90917374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.26082143
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.25368025
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.16426421
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.10557921
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.70588874
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.29103007
7MYC_22102868_ChIP-Seq_BL_Human2.83363848
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.70255210
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.67058705
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.65327668
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42388560
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.39234490
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35921994
14RUNX_20019798_ChIP-Seq_JUKART_Human2.34267286
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24883305
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.24709541
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.21798611
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.21535558
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19629023
20KDM2B_26808549_Chip-Seq_DND41_Human2.17394568
21TCF7_22412390_ChIP-Seq_EML_Mouse2.17050960
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.11036981
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03545257
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98057282
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97310854
26IGF1R_20145208_ChIP-Seq_DFB_Human1.96401417
27SPI1_23127762_ChIP-Seq_K562_Human1.93823339
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92797981
29MYB_26560356_Chip-Seq_TH2_Human1.90735786
30* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90284361
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89098146
32GATA1_22025678_ChIP-Seq_K562_Human1.89015014
33MAF_26560356_Chip-Seq_TH1_Human1.88860681
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86953224
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.83025721
36VDR_24763502_ChIP-Seq_THP-1_Human1.81377127
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.81045744
38* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.80634001
39VDR_21846776_ChIP-Seq_THP-1_Human1.78886411
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.76449913
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75201514
42TAF15_26573619_Chip-Seq_HEK293_Human1.68746839
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.68630941
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.68630941
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67965764
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.67095198
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65910931
48SCL_19346495_ChIP-Seq_HPC-7_Human1.65623641
49SMAD4_21799915_ChIP-Seq_A2780_Human1.65303613
50UTX_26944678_Chip-Seq_JUKART_Human1.62286780
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61779275
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.61255707
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.59212478
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58741777
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.58310035
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56702014
57FUS_26573619_Chip-Seq_HEK293_Human1.55146830
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.53558966
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53334703
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52393121
61MYB_26560356_Chip-Seq_TH1_Human1.52129224
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51473198
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.50925404
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.49909514
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49544290
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49357954
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49177841
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.48329076
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44639704
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44503661
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43639518
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42957681
73STAT3_23295773_ChIP-Seq_U87_Human1.41796406
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40077262
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39250575
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.39044954
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37243211
78GBX2_23144817_ChIP-Seq_PC3_Human1.36729101
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36638748
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35655187
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35409876
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35215522
83KDM2B_26808549_Chip-Seq_K562_Human1.34229425
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34220113
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33870932
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33459904
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33432374
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33432374
89GATA3_27048872_Chip-Seq_THYMUS_Human1.32879966
90TP63_23658742_ChIP-Seq_EP156T_Human1.32602092
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32329858
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.31714694
93STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31379458
94* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29654933
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26940767
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26905191
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.24993742
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24211289
99BRD4_25478319_ChIP-Seq_HGPS_Human1.23246878
100* PU_27001747_Chip-Seq_BMDM_Mouse1.23134083
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22969733
102TCF4_23295773_ChIP-Seq_U87_Human1.22206270
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21380608
104P300_19829295_ChIP-Seq_ESCs_Human1.20898307
105AHR_22903824_ChIP-Seq_MCF-7_Human1.19470514
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.18757932
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18696758
108LXR_22292898_ChIP-Seq_THP-1_Human1.18601655
109ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18411005
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18124867
111ER_23166858_ChIP-Seq_MCF-7_Human1.17432283
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16118014
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14621694
114CDX2_22108803_ChIP-Seq_LS180_Human1.13987378
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13365507
116RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13073368
117TP53_18474530_ChIP-ChIP_U2OS_Human1.12936752
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11592118
119CLOCK_20551151_ChIP-Seq_293T_Human1.11549143
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.11469516
121ESR1_20079471_ChIP-ChIP_T-47D_Human1.11398588
122VDR_24787735_ChIP-Seq_THP-1_Human1.11156495
123GATA1_19941826_ChIP-Seq_K562_Human1.10724616
124ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10365999
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10291142
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09878918
127PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09815735
128AR_25329375_ChIP-Seq_VCAP_Human1.09119575
129* RUNX1_22412390_ChIP-Seq_EML_Mouse1.08239414
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07952019
131ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06985473
132E2F1_18555785_Chip-Seq_ESCs_Mouse1.06879904
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06817910
134GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05484355
135TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04748084
136EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04537328
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04502456
138* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04344270
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02962676
140SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02633167
141EWS_26573619_Chip-Seq_HEK293_Human1.01506898
142NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01495324
143RACK7_27058665_Chip-Seq_MCF-7_Human1.00360923
144CJUN_26792858_Chip-Seq_BT549_Human0.99768860
145FLI1_21867929_ChIP-Seq_TH2_Mouse0.99634636
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99249279
147* CMYC_18555785_Chip-Seq_ESCs_Mouse0.98261429
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.98136206
149PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97877225
150* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97430970
151ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97127899
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97036191
153CBP_20019798_ChIP-Seq_JUKART_Human0.97036191
154SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96675993
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94785001
156KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94421989
157UBF1/2_26484160_Chip-Seq_HMECs_Human0.93770098
158MAF_26560356_Chip-Seq_TH2_Human0.93284236
159* SPI1_23547873_ChIP-Seq_NB4_Human0.93263533
160CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93049697
161WT1_19549856_ChIP-ChIP_CCG9911_Human0.92788346
162NCOR1_26117541_ChIP-Seq_K562_Human0.90632531
163IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90067818
164CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90041422
165ESR2_21235772_ChIP-Seq_MCF-7_Human0.89794924
166TP53_16413492_ChIP-PET_HCT116_Human0.89506783
167SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88512028
168TBX20_22328084_ChIP-Seq_HEART_Mouse0.88437722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.98702816
2MP0005451_abnormal_body_composition4.11393752
3MP0005076_abnormal_cell_differentiation2.90239754
4MP0003300_gastrointestinal_ulcer2.86476677
5MP0003303_peritoneal_inflammation2.81448660
6MP0000569_abnormal_digit_pigmentation2.74208722
7MP0003221_abnormal_cardiomyocyte_apopto2.50378316
8MP0010352_gastrointestinal_tract_polyps2.35978297
9MP0001835_abnormal_antigen_presentation2.33198206
10MP0009278_abnormal_bone_marrow2.16596715
11MP0009697_abnormal_copulation2.12523661
12MP0003705_abnormal_hypodermis_morpholog2.12410597
13MP0003436_decreased_susceptibility_to2.11004847
14MP0008438_abnormal_cutaneous_collagen2.07200176
15MP0004084_abnormal_cardiac_muscle2.03595709
16MP0000685_abnormal_immune_system2.00021519
17MP0003045_fibrosis1.97267234
18MP0005387_immune_system_phenotype1.94486996
19MP0001790_abnormal_immune_system1.94486996
20MP0004808_abnormal_hematopoietic_stem1.79828848
21MP0005000_abnormal_immune_tolerance1.79242682
22MP0004510_myositis1.77728034
23MP0003566_abnormal_cell_adhesion1.77493546
24MP0010234_abnormal_vibrissa_follicle1.76336141
25MP0004272_abnormal_basement_membrane1.73414895
26MP0010678_abnormal_skin_adnexa1.73173430
27MP0003091_abnormal_cell_migration1.72381713
28MP0003656_abnormal_erythrocyte_physiolo1.71319285
29MP0005671_abnormal_response_to1.69349459
30MP0001800_abnormal_humoral_immune1.69339498
31MP0003122_maternal_imprinting1.68901017
32MP0000465_gastrointestinal_hemorrhage1.67327825
33MP0002877_abnormal_melanocyte_morpholog1.62328578
34MP0002452_abnormal_antigen_presenting1.61828064
35MP0002396_abnormal_hematopoietic_system1.61432925
36MP0002723_abnormal_immune_serum1.56143374
37MP0003448_altered_tumor_morphology1.55278610
38MP0001533_abnormal_skeleton_physiology1.55088885
39MP0004036_abnormal_muscle_relaxation1.54317844
40MP0008961_abnormal_basal_metabolism1.53283798
41MP0000383_abnormal_hair_follicle1.52712825
42MP0005248_abnormal_Harderian_gland1.48783218
43MP0009785_altered_susceptibility_to1.48489071
44MP0000733_abnormal_muscle_development1.46673084
45MP0005623_abnormal_meninges_morphology1.44776285
46MP0001819_abnormal_immune_cell1.42761887
47MP0005174_abnormal_tail_pigmentation1.42681872
48MP0006054_spinal_hemorrhage1.42090766
49MP0003950_abnormal_plasma_membrane1.42035057
50MP0002420_abnormal_adaptive_immunity1.41351061
51MP0003763_abnormal_thymus_physiology1.40090524
52MP0006082_CNS_inflammation1.37391445
53MP0003724_increased_susceptibility_to1.37260636
54MP0002398_abnormal_bone_marrow1.37204224
55MP0003279_aneurysm1.36685625
56MP0002419_abnormal_innate_immunity1.35279540
57MP0005397_hematopoietic_system_phenotyp1.34830840
58MP0001545_abnormal_hematopoietic_system1.34830840
59MP0003868_abnormal_feces_composition1.34826792
60MP0009115_abnormal_fat_cell1.32886941
61MP0001348_abnormal_lacrimal_gland1.32873818
62MP0005025_abnormal_response_to1.32322662
63MP0002006_tumorigenesis1.30094327
64MP0003172_abnormal_lysosome_physiology1.29911124
65MP0009333_abnormal_splenocyte_physiolog1.27806961
66MP0005503_abnormal_tendon_morphology1.25940105
67MP0004947_skin_inflammation1.25925039
68MP0002405_respiratory_system_inflammati1.25594463
69MP0005023_abnormal_wound_healing1.23295610
70MP0010307_abnormal_tumor_latency1.21203830
71MP0002127_abnormal_cardiovascular_syste1.20922482
72MP0001986_abnormal_taste_sensitivity1.19810770
73MP0002166_altered_tumor_susceptibility1.19150240
74MP0002148_abnormal_hypersensitivity_rea1.19120977
75MP0000003_abnormal_adipose_tissue1.19035997
76MP0005666_abnormal_adipose_tissue1.18942618
77MP0002933_joint_inflammation1.18930592
78MP0001958_emphysema1.18017946
79MP0009780_abnormal_chondrocyte_physiolo1.16895989
80MP0004134_abnormal_chest_morphology1.16014600
81MP0003183_abnormal_peptide_metabolism1.15508738
82MP0000716_abnormal_immune_system1.14952590
83MP0000013_abnormal_adipose_tissue1.14622176
84MP0000703_abnormal_thymus_morphology1.14140336
85MP0002998_abnormal_bone_remodeling1.13402393
86MP0004484_altered_response_of1.11947068
87MP0005409_darkened_coat_color1.07852326
88MP0001849_ear_inflammation1.07449110
89MP0010155_abnormal_intestine_physiology1.07199438
90MP0001915_intracranial_hemorrhage1.04960334
91MP0001851_eye_inflammation1.04845019
92MP0010368_abnormal_lymphatic_system1.03720006
93MP0009384_cardiac_valve_regurgitation1.03328323
94MP0003787_abnormal_imprinting1.03037464
95MP0000858_altered_metastatic_potential1.01803050
96MP0002332_abnormal_exercise_endurance1.01065652
97MP0002139_abnormal_hepatobiliary_system1.00998791
98MP0005390_skeleton_phenotype1.00719468
99MP0008004_abnormal_stomach_pH0.99957169
100MP0005275_abnormal_skin_tensile0.99855774
101* MP0002925_abnormal_cardiovascular_devel0.99251471
102MP0006138_congestive_heart_failure0.98118599
103MP0003121_genomic_imprinting0.97952058
104MP0004858_abnormal_nervous_system0.97794276
105MP0003943_abnormal_hepatobiliary_system0.97129410
106MP0005164_abnormal_response_to0.96860429
107MP0002233_abnormal_nose_morphology0.96573710
108MP0003984_embryonic_growth_retardation0.95654198
109MP0002722_abnormal_immune_system0.93508449
110MP0005621_abnormal_cell_physiology0.93399048
111MP0001216_abnormal_epidermal_layer0.91242055
112MP0001879_abnormal_lymphatic_vessel0.91169406
113MP0001299_abnormal_eye_distance/0.91122950
114MP0001784_abnormal_fluid_regulation0.90883623
115MP0002088_abnormal_embryonic_growth/wei0.90617040
116MP0000767_abnormal_smooth_muscle0.90557475
117MP0001845_abnormal_inflammatory_respons0.90184711
118MP0000428_abnormal_craniofacial_morphol0.89406061
119MP0002429_abnormal_blood_cell0.88705593
120MP0000427_abnormal_hair_cycle0.88488386
121MP0002168_other_aberrant_phenotype0.88327676
122MP0002128_abnormal_blood_circulation0.88128320
123MP0005310_abnormal_salivary_gland0.88052610
124MP0004197_abnormal_fetal_growth/weight/0.87079896
125MP0008995_early_reproductive_senescence0.87024840
126MP0000689_abnormal_spleen_morphology0.86943113
127MP0003828_pulmonary_edema0.86867781
128MP0008789_abnormal_olfactory_epithelium0.86470576
129* MP0002086_abnormal_extraembryonic_tissu0.86116030
130MP0005187_abnormal_penis_morphology0.86050194
131MP0004185_abnormal_adipocyte_glucose0.84822467
132MP0002928_abnormal_bile_duct0.84758253
133* MP0000266_abnormal_heart_morphology0.84588538
134MP0002796_impaired_skin_barrier0.84027971
135MP0000343_altered_response_to0.82918183
136MP0003646_muscle_fatigue0.81370423
137MP0001672_abnormal_embryogenesis/_devel0.81018649
138MP0005380_embryogenesis_phenotype0.81018649
139MP0008057_abnormal_DNA_replication0.80918420
140MP0001191_abnormal_skin_condition0.80496133
141MP0000249_abnormal_blood_vessel0.79122329
142MP0005375_adipose_tissue_phenotype0.78059502
143MP0002909_abnormal_adrenal_gland0.77971550
144MP0002896_abnormal_bone_mineralization0.76328352
145MP0002653_abnormal_ependyma_morphology0.75437264
146MP0010630_abnormal_cardiac_muscle0.74728437
147MP0004883_abnormal_blood_vessel0.74279380
148MP0003252_abnormal_bile_duct0.73849868
149MP0002060_abnormal_skin_morphology0.73787723
150MP0002092_abnormal_eye_morphology0.73327645
151MP0005384_cellular_phenotype0.72320646
152MP0000377_abnormal_hair_follicle0.72043330
153MP0003935_abnormal_craniofacial_develop0.70806435
154MP0002113_abnormal_skeleton_development0.69250925
155* MP0001614_abnormal_blood_vessel0.68975789
156MP0002971_abnormal_brown_adipose0.68907405
157MP0003795_abnormal_bone_structure0.68508562
158MP0005501_abnormal_skin_physiology0.67462092
159MP0002084_abnormal_developmental_patter0.67318985

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)5.15434778
2B lymphocytopenia (HP:0010976)3.65500210
3Thyroid carcinoma (HP:0002890)3.36884378
4Cerebral aneurysm (HP:0004944)3.18883975
5Hypoplasia of the thymus (HP:0000778)3.15519945
6Abnormality of B cell number (HP:0010975)3.14611870
7Shallow orbits (HP:0000586)3.04073840
8Cervical subluxation (HP:0003308)2.99512894
9Subacute progressive viral hepatitis (HP:0006572)2.97667572
10Severe combined immunodeficiency (HP:0004430)2.95774220
11Aortic aneurysm (HP:0004942)2.91500009
12Thyroiditis (HP:0100646)2.85977958
13Abnormality of the fingertips (HP:0001211)2.85675056
14Short 4th metacarpal (HP:0010044)2.75269318
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75269318
16Abnormality of the nasal septum (HP:0000419)2.65976664
17Hypoproteinemia (HP:0003075)2.61968946
18Heterotopia (HP:0002282)2.58570632
19Widely spaced teeth (HP:0000687)2.58204773
20Myositis (HP:0100614)2.53659258
21Medulloblastoma (HP:0002885)2.53365983
22Chronic hepatic failure (HP:0100626)2.50764569
23Macroorchidism (HP:0000053)2.49547813
24Insidious onset (HP:0003587)2.46817776
25Termporal pattern (HP:0011008)2.46817776
26Large earlobe (HP:0009748)2.44308205
27Combined immunodeficiency (HP:0005387)2.42340693
28Orchitis (HP:0100796)2.39793476
29Recurrent viral infections (HP:0004429)2.39148646
30Rhabdomyosarcoma (HP:0002859)2.37790219
31Absent speech (HP:0001344)2.35554526
32Dilatation of the ascending aorta (HP:0005111)2.35013739
33Spondylolisthesis (HP:0003302)2.34766393
34Trigonocephaly (HP:0000243)2.32244229
35Narrow palate (HP:0000189)2.29231351
36Curly hair (HP:0002212)2.26284609
37Hyperventilation (HP:0002883)2.25413855
38Hyperacusis (HP:0010780)2.24672469
39Increased density of long bones (HP:0006392)2.24291736
40Recurrent fungal infections (HP:0002841)2.23781074
41Erythroderma (HP:0001019)2.23450041
42Cubitus valgus (HP:0002967)2.21531651
43Vertebral arch anomaly (HP:0008438)2.21238671
44Optic neuritis (HP:0100653)2.21137153
45Retrobulbar optic neuritis (HP:0100654)2.21137153
46Increased cerebral lipofuscin (HP:0011813)2.15293199
47Thickened helices (HP:0000391)2.15165216
48Long eyelashes (HP:0000527)2.14784745
49Dislocated radial head (HP:0003083)2.14369858
50Subaortic stenosis (HP:0001682)2.14361486
51Abnormality of the left ventricular outflow tract (HP:0011103)2.14361486
52Protrusio acetabuli (HP:0003179)2.11026214
53Eczematoid dermatitis (HP:0000976)2.10472794
54Vascular tortuosity (HP:0004948)2.10066512
55Biliary tract neoplasm (HP:0100574)2.09191542
56Tapered finger (HP:0001182)2.09087140
57Recurrent cutaneous fungal infections (HP:0011370)2.08455545
58Chronic mucocutaneous candidiasis (HP:0002728)2.08455545
59Bicuspid aortic valve (HP:0001647)2.07655587
60Elevated erythrocyte sedimentation rate (HP:0003565)2.06923085
61Arterial tortuosity (HP:0005116)2.06600650
62Eosinophilia (HP:0001880)2.06182766
63Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.06067866
64T lymphocytopenia (HP:0005403)2.05167102
65Neoplasm of the tracheobronchial system (HP:0100552)2.04821955
66Fatigue (HP:0012378)2.04423207
67Abnormality of the radial head (HP:0003995)2.04042842
68Cystic hygroma (HP:0000476)2.03027466
69Relative macrocephaly (HP:0004482)2.00921582
70Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.00666058
71Hematochezia (HP:0002573)2.00423917
72Aneurysm (HP:0002617)1.99948877
73Aortic dissection (HP:0002647)1.99560192
74Arterial thrombosis (HP:0004420)1.98275200
75Interstitial pulmonary disease (HP:0006530)1.97663766
76Broad thumb (HP:0011304)1.97144397
77Genetic anticipation (HP:0003743)1.96417320
78Pulmonic stenosis (HP:0001642)1.95963580
79Mitral valve prolapse (HP:0001634)1.95337031
80Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.95298192
81Syringomyelia (HP:0003396)1.95272692
82Spinal cord lesions (HP:0100561)1.95272692
83Deep philtrum (HP:0002002)1.94852876
84Striae distensae (HP:0001065)1.93772232
85Absent frontal sinuses (HP:0002688)1.93156069
86Fair hair (HP:0002286)1.92578434
87Drooling (HP:0002307)1.90760983
88Cone-rod dystrophy (HP:0000548)1.89787960
89Open mouth (HP:0000194)1.89354122
90Overgrowth (HP:0001548)1.87827469
91Abnormality of the 4th metacarpal (HP:0010012)1.86542975
92Tubulointerstitial nephritis (HP:0001970)1.84638453
93Neoplasm of striated muscle (HP:0009728)1.84223105
94Abnormal hair whorl (HP:0010721)1.84163599
95Abnormality of the epiphyses of the hand (HP:0005924)1.83791853
96Enlarged penis (HP:0000040)1.83110308
97Excessive salivation (HP:0003781)1.82811476
98Milia (HP:0001056)1.82539848
99Ankle contracture (HP:0006466)1.81928018
100Rimmed vacuoles (HP:0003805)1.81588931
101Autoamputation (HP:0001218)1.81398275
102Nasal polyposis (HP:0100582)1.81133841
103Hyperkalemia (HP:0002153)1.80715817
104Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80392019
105Increased neuronal autofluorescent lipopigment (HP:0002074)1.80339863
106Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.80189453
107Abnormal delayed hypersensitivity skin test (HP:0002963)1.79614667
108Urethral obstruction (HP:0000796)1.79422367
109Broad metatarsal (HP:0001783)1.78918734
110Coarse hair (HP:0002208)1.78724919
111Bladder diverticulum (HP:0000015)1.78049981
112Abnormality of T cell number (HP:0011839)1.77620322
113Recurrent bronchitis (HP:0002837)1.77112275
114Ectropion (HP:0000656)1.76874273
115Disproportionate tall stature (HP:0001519)1.75896724
116Joint laxity (HP:0001388)1.75047791
117Renal duplication (HP:0000075)1.74358704
118Abnormality of the nasal mucosa (HP:0000433)1.73936782
119Lip pit (HP:0100267)1.73787353
120Amyotrophic lateral sclerosis (HP:0007354)1.72972111
121Viral hepatitis (HP:0006562)1.72195373
122Thick eyebrow (HP:0000574)1.71992701
123Premature rupture of membranes (HP:0001788)1.71264408
124Abnormality of the astrocytes (HP:0100707)1.71178737
125Astrocytoma (HP:0009592)1.71178737
126Ulnar deviation of the wrist (HP:0003049)1.70919329
127Flared iliac wings (HP:0002869)1.70663357
128Hand muscle atrophy (HP:0009130)1.69673210
129Mucopolysacchariduria (HP:0008155)1.69403223
130Urinary glycosaminoglycan excretion (HP:0003541)1.69403223
131Abnormality of the columella (HP:0009929)1.69072004
132Distal upper limb amyotrophy (HP:0007149)1.68622529
133Upper limb amyotrophy (HP:0009129)1.68622529
134Abnormality of nail color (HP:0100643)1.68579144
135Increased nuchal translucency (HP:0010880)1.68197002
136Atrophic scars (HP:0001075)1.67413000
137Cellulitis (HP:0100658)1.67329347
138Right ventricular cardiomyopathy (HP:0011663)1.67067884
139Transitional cell carcinoma of the bladder (HP:0006740)1.65939658
140Volvulus (HP:0002580)1.65773886
141Granulocytopenia (HP:0001913)1.65474400
142Persistence of primary teeth (HP:0006335)1.65452056
143Vacuolated lymphocytes (HP:0001922)1.65419691
144Abnormal biliary tract morphology (HP:0012440)1.65371933
145Hypercortisolism (HP:0001578)1.65268176
146Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.65245834
147Panhypogammaglobulinemia (HP:0003139)1.64971741
148Broad phalanges of the hand (HP:0009768)1.64834352
149Thick nail (HP:0001805)1.64275668
150Porencephaly (HP:0002132)1.64227298
151Freckling (HP:0001480)1.64089411
152Gastrointestinal inflammation (HP:0004386)1.63433219
153Hypoplastic labia majora (HP:0000059)1.63166336
154Portal hypertension (HP:0001409)1.62289412
155Neoplasm of the heart (HP:0100544)1.61434521
156Scapular winging (HP:0003691)1.61176728
157Bladder carcinoma (HP:0002862)1.61144031
158Bladder neoplasm (HP:0009725)1.61144031
159Low anterior hairline (HP:0000294)1.60364624
160Capillary hemangiomas (HP:0005306)1.59801155
161Acute myeloid leukemia (HP:0004808)1.59696472
162Deviation of the hallux (HP:0010051)1.59363810
163Alopecia of scalp (HP:0002293)1.59262765
164Neoplasm of the small intestine (HP:0100833)1.59224823
165Broad finger (HP:0001500)1.58256604
166Elfin facies (HP:0004428)1.58242323
167Hallux valgus (HP:0001822)1.57981595
168Osteolytic defects of the phalanges of the hand (HP:0009771)1.57425449
169Osteolytic defects of the hand bones (HP:0009699)1.57425449
170Chronic otitis media (HP:0000389)1.57126264
171Recurrent abscess formation (HP:0002722)1.55850014
172Mediastinal lymphadenopathy (HP:0100721)1.55737865
173Abnormality of mucopolysaccharide metabolism (HP:0011020)1.54887762
174Abnormality of polysaccharide metabolism (HP:0011012)1.54887762
175Abnormality of glycosaminoglycan metabolism (HP:0004371)1.54887762
176Alveolar cell carcinoma (HP:0006519)1.54622323
177Truncal obesity (HP:0001956)1.54107110
178Chest pain (HP:0100749)1.53493490
179Genu recurvatum (HP:0002816)1.53047614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR2.62353341
2TRIB32.56954189
3ERN12.56048152
4MAP4K12.52895393
5CDK122.44679750
6AKT32.43199460
7CAMK1G2.26937150
8EIF2AK32.19737140
9SIK32.17131794
10MAP3K102.14715494
11EPHB12.07266539
12MET2.01431100
13PKN21.96333174
14CAMK1D1.92411186
15TGFBR21.91670376
16ERBB31.88767863
17TIE11.85008277
18MAP3K41.81423706
19TYK21.78039986
20JAK31.73702523
21EEF2K1.72755975
22SIK11.68367077
23PTK61.66830042
24KIT1.65035725
25PDGFRA1.64807164
26CHUK1.64417187
27TBK11.63005282
28ZAP701.62413811
29SIK21.61471837
30FGFR31.61321781
31EPHA31.60214699
32YES11.56897382
33MST41.56581926
34BMPR21.55454300
35PIK3CG1.53999069
36EPHB21.52531260
37RPS6KA41.52480825
38DYRK31.51843855
39TTN1.47629886
40JAK11.46744299
41CCNB11.46626060
42TRPM71.45297183
43STK101.44000646
44BRD41.42857148
45MAP3K61.37860149
46PRKD31.36141961
47MTOR1.34945351
48ICK1.34915586
49STK38L1.34021761
50NEK11.32664036
51IKBKE1.32385769
52SGK21.30504486
53STK391.29459198
54RIPK11.29034256
55FGFR41.28851926
56DMPK1.26827093
57FER1.25065616
58MAP3K141.23643450
59TXK1.22484606
60SCYL21.19623741
61MAP3K21.18328685
62STK241.17466840
63MAP4K21.15083653
64SGK31.15079870
65IRAK41.13637715
66CSK1.10270992
67BRSK21.09923133
68TRIM281.07868466
69CDK61.07327385
70ALK1.06140400
71RET1.04578739
72NLK1.04374293
73KSR21.02752556
74PASK0.96711000
75CDC42BPA0.96035313
76LATS10.95940532
77HCK0.95913798
78PRKD20.95619576
79OBSCN0.95478011
80PAK20.89965505
81MAPK70.89600234
82FLT30.88821241
83MAP3K70.88177497
84BLK0.87829543
85PDGFRB0.87685381
86DYRK1B0.87477613
87TAOK30.85592395
88BMX0.85326214
89ITK0.84681511
90MST1R0.82849054
91PTK20.82657966
92BTK0.82226824
93LRRK20.81918959
94PRPF4B0.80845818
95IKBKB0.80453960
96CAMKK10.77153715
97FGFR10.75127899
98HIPK20.74718428
99TEC0.73973695
100MAP3K130.72785282
101TESK10.72063572
102CSF1R0.71261491
103STK30.70045639
104TAOK10.69319277
105RAF10.69028430
106STK380.66971355
107TGFBR10.66084395
108EGFR0.65130959
109SGK2230.64597449
110SGK4940.64597449
111INSRR0.63480236
112LCK0.63025972
113MARK30.62820110
114FES0.61274027
115CDK90.60446355
116MAP2K70.60347720
117PRKAA20.60341940
118PRKCH0.60187025
119RPS6KB10.59257066
120CSNK1A1L0.59206949
121IRAK30.59125095
122FGR0.58537687
123MAPK100.58006639
124MAP3K50.57374387
125JAK20.57235857
126CAMK40.53573776
127PRKAA10.52826083
128PAK40.52493356
129PTK2B0.51765036
130NEK90.50722161
131IRAK10.50572331
132SYK0.50512496
133MARK20.48954287
134FYN0.48648220
135DDR20.48628784
136RPS6KA20.48141323
137ABL10.46311744
138MAP3K30.45945648
139ERBB40.45305497
140TYRO30.44437723
141BMPR1B0.43823126
142RIPK40.43561838
143WNK10.43183834
144NEK60.42722483
145MATK0.42619018
146MAPKAPK20.42197988
147CDK40.41667553
148KSR10.41663855
149SRC0.41614401
150FRK0.40155658
151DYRK1A0.39124712
152MAP3K10.37768452
153MAP3K120.36144779
154MAPK10.34559803
155ATM0.34141018

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047102.64351598
2Leishmaniasis_Homo sapiens_hsa051402.01991459
3Osteoclast differentiation_Homo sapiens_hsa043801.68083997
4Non-homologous end-joining_Homo sapiens_hsa034501.56064988
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55487852
6B cell receptor signaling pathway_Homo sapiens_hsa046621.51554246
7Chronic myeloid leukemia_Homo sapiens_hsa052201.47434406
8Viral myocarditis_Homo sapiens_hsa054161.47207903
9Toxoplasmosis_Homo sapiens_hsa051451.46854171
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39927196
11Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38865152
12Adherens junction_Homo sapiens_hsa045201.37177465
13Inositol phosphate metabolism_Homo sapiens_hsa005621.35181786
14Measles_Homo sapiens_hsa051621.34629511
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34550701
16T cell receptor signaling pathway_Homo sapiens_hsa046601.34173558
17ErbB signaling pathway_Homo sapiens_hsa040121.33986509
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33125044
19TNF signaling pathway_Homo sapiens_hsa046681.32309831
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.32236762
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29533680
22Antigen processing and presentation_Homo sapiens_hsa046121.28998623
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28543160
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.27817986
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.24084923
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23789850
27Hepatitis B_Homo sapiens_hsa051611.21684837
28Tuberculosis_Homo sapiens_hsa051521.20519769
29Influenza A_Homo sapiens_hsa051641.20295252
30Colorectal cancer_Homo sapiens_hsa052101.20195901
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19343919
32Pertussis_Homo sapiens_hsa051331.18250376
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17563784
34Shigellosis_Homo sapiens_hsa051311.17354680
35Proteoglycans in cancer_Homo sapiens_hsa052051.16587944
36Choline metabolism in cancer_Homo sapiens_hsa052311.15359050
37Primary immunodeficiency_Homo sapiens_hsa053401.14284140
38Thyroid cancer_Homo sapiens_hsa052161.13425226
39Pancreatic cancer_Homo sapiens_hsa052121.12705796
40Amoebiasis_Homo sapiens_hsa051461.12694139
41Acute myeloid leukemia_Homo sapiens_hsa052211.11221727
42Legionellosis_Homo sapiens_hsa051341.10089574
43Focal adhesion_Homo sapiens_hsa045101.08379518
44Malaria_Homo sapiens_hsa051441.08292561
45MicroRNAs in cancer_Homo sapiens_hsa052061.07420648
46Notch signaling pathway_Homo sapiens_hsa043301.07247935
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05842921
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05013037
49Type II diabetes mellitus_Homo sapiens_hsa049301.04896036
50Salmonella infection_Homo sapiens_hsa051321.04480888
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02465801
52TGF-beta signaling pathway_Homo sapiens_hsa043501.02331041
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01798396
54Dorso-ventral axis formation_Homo sapiens_hsa043201.01752814
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.01669697
56Herpes simplex infection_Homo sapiens_hsa051681.01515555
57Chemokine signaling pathway_Homo sapiens_hsa040621.01441555
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.00026619
59Hematopoietic cell lineage_Homo sapiens_hsa046400.98610488
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97158754
61VEGF signaling pathway_Homo sapiens_hsa043700.95368352
62Small cell lung cancer_Homo sapiens_hsa052220.95242701
63HTLV-I infection_Homo sapiens_hsa051660.95161614
64Platelet activation_Homo sapiens_hsa046110.93817056
65mTOR signaling pathway_Homo sapiens_hsa041500.92127147
66ECM-receptor interaction_Homo sapiens_hsa045120.92028059
67Prolactin signaling pathway_Homo sapiens_hsa049170.89987877
68Insulin signaling pathway_Homo sapiens_hsa049100.89351312
69Insulin resistance_Homo sapiens_hsa049310.84676158
70Apoptosis_Homo sapiens_hsa042100.83542983
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.83269742
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83094001
73Type I diabetes mellitus_Homo sapiens_hsa049400.83073084
74Dilated cardiomyopathy_Homo sapiens_hsa054140.81102655
75Graft-versus-host disease_Homo sapiens_hsa053320.80331181
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79072484
77Renal cell carcinoma_Homo sapiens_hsa052110.78703223
78Allograft rejection_Homo sapiens_hsa053300.78461382
79Glioma_Homo sapiens_hsa052140.77919128
80Lysosome_Homo sapiens_hsa041420.77894790
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77790845
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76200267
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75855305
84Estrogen signaling pathway_Homo sapiens_hsa049150.75664784
85Endocytosis_Homo sapiens_hsa041440.75181457
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.74906660
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74059307
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73957693
89MAPK signaling pathway_Homo sapiens_hsa040100.73939006
90Endometrial cancer_Homo sapiens_hsa052130.73930639
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73890927
92Prostate cancer_Homo sapiens_hsa052150.73721893
93Regulation of autophagy_Homo sapiens_hsa041400.72899035
94Other glycan degradation_Homo sapiens_hsa005110.72216564
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71772911
96Wnt signaling pathway_Homo sapiens_hsa043100.71273795
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70890542
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70434068
99Pathways in cancer_Homo sapiens_hsa052000.69924862
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68997945
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.68426478
102African trypanosomiasis_Homo sapiens_hsa051430.68094197
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67877554
104AMPK signaling pathway_Homo sapiens_hsa041520.67319420
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65498506
106Non-small cell lung cancer_Homo sapiens_hsa052230.64984914
107Rap1 signaling pathway_Homo sapiens_hsa040150.64620597
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63902856
109HIF-1 signaling pathway_Homo sapiens_hsa040660.63154190
110Viral carcinogenesis_Homo sapiens_hsa052030.61986237
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.61876785
112Complement and coagulation cascades_Homo sapiens_hsa046100.61459851
113FoxO signaling pathway_Homo sapiens_hsa040680.60729549
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60047277
115Lysine degradation_Homo sapiens_hsa003100.59436230
116Rheumatoid arthritis_Homo sapiens_hsa053230.59129159
117Hepatitis C_Homo sapiens_hsa051600.58853944
118Glucagon signaling pathway_Homo sapiens_hsa049220.58615615
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58430435
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58264349
121Tight junction_Homo sapiens_hsa045300.56735232
122Ras signaling pathway_Homo sapiens_hsa040140.55822678
123Long-term potentiation_Homo sapiens_hsa047200.54832070
124Axon guidance_Homo sapiens_hsa043600.54128815
125Gap junction_Homo sapiens_hsa045400.53822436
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.52075948
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51979623
128Renin secretion_Homo sapiens_hsa049240.51490009
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49082790

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