SEC24C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.85279088
2Golgi transport vesicle coating (GO:0048200)5.85279088
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.68187976
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.68187976
5protein localization to endosome (GO:0036010)4.16251634
6antigen processing and presentation of endogenous antigen (GO:0019883)4.10563307
7alpha-linolenic acid metabolic process (GO:0036109)3.91504012
8regulation of gamma-delta T cell differentiation (GO:0045586)3.88167066
9regulation of cholesterol homeostasis (GO:2000188)3.83114352
10lysine metabolic process (GO:0006553)3.73647022
11lysine catabolic process (GO:0006554)3.73647022
12regulation of histone H3-K27 methylation (GO:0061085)3.71976212
13valine metabolic process (GO:0006573)3.58885593
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.55066877
15positive regulation of histone deacetylation (GO:0031065)3.53395749
16mannose metabolic process (GO:0006013)3.44422607
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.43729413
18L-phenylalanine catabolic process (GO:0006559)3.43729413
19positive regulation of nuclease activity (GO:0032075)3.43522566
20positive regulation of gamma-delta T cell activation (GO:0046645)3.38998491
21regulation of gamma-delta T cell activation (GO:0046643)3.36239418
22nuclear pore complex assembly (GO:0051292)3.35502241
23regulation of fatty acid beta-oxidation (GO:0031998)3.32475121
24tricarboxylic acid metabolic process (GO:0072350)3.30018806
25L-phenylalanine metabolic process (GO:0006558)3.28259458
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.28259458
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27279376
28cell-substrate adherens junction assembly (GO:0007045)3.24286102
29focal adhesion assembly (GO:0048041)3.24286102
30spliceosomal tri-snRNP complex assembly (GO:0000244)3.21373181
31adherens junction assembly (GO:0034333)3.20821969
32activation of Rac GTPase activity (GO:0032863)3.17396924
33* COPII vesicle coating (GO:0048208)3.16368245
34regulation of early endosome to late endosome transport (GO:2000641)3.15817796
35regulation of nuclease activity (GO:0032069)3.14619556
362-oxoglutarate metabolic process (GO:0006103)3.14552154
374-hydroxyproline metabolic process (GO:0019471)3.12999632
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.11867120
39cell-substrate junction assembly (GO:0007044)3.08278377
40urea cycle (GO:0000050)3.06697256
41urea metabolic process (GO:0019627)3.06697256
42stress fiber assembly (GO:0043149)3.05712066
43positive thymic T cell selection (GO:0045059)3.05226214
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.04067144
45endoplasmic reticulum unfolded protein response (GO:0030968)3.02996760
46proline biosynthetic process (GO:0006561)3.00237166
47sulfur amino acid catabolic process (GO:0000098)3.00014398
48folic acid-containing compound biosynthetic process (GO:0009396)2.98694782
49negative regulation of cell size (GO:0045792)2.98032512
50negative regulation of cholesterol transport (GO:0032375)2.96646600
51negative regulation of sterol transport (GO:0032372)2.96646600
52kynurenine metabolic process (GO:0070189)2.96207682
53skin morphogenesis (GO:0043589)2.94121282
54triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.93790560
55regulation of RNA export from nucleus (GO:0046831)2.91002032
56cytoskeletal anchoring at plasma membrane (GO:0007016)2.90145778
57pinocytosis (GO:0006907)2.89365392
58cellular response to unfolded protein (GO:0034620)2.87816138
59positive regulation of Cdc42 GTPase activity (GO:0043089)2.87601089
60embryonic process involved in female pregnancy (GO:0060136)2.87546545
61negative regulation of fibrinolysis (GO:0051918)2.87079532
62positive regulation of fatty acid beta-oxidation (GO:0032000)2.86881209
63regulation of nucleobase-containing compound transport (GO:0032239)2.84999070
64glucose 6-phosphate metabolic process (GO:0051156)2.84498281
65ER-nucleus signaling pathway (GO:0006984)2.82177491
66L-alpha-amino acid transmembrane transport (GO:1902475)2.81132597
67regulation of glucose import in response to insulin stimulus (GO:2001273)2.79741973
68complement activation, alternative pathway (GO:0006957)2.77851492
69antigen processing and presentation via MHC class Ib (GO:0002475)2.77379743
70protein retention in ER lumen (GO:0006621)2.75509626
71aromatic amino acid family catabolic process (GO:0009074)2.75484410
72maternal placenta development (GO:0001893)2.71012748
73regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70554384
74cellular response to topologically incorrect protein (GO:0035967)2.70355578
75regulation of protein activation cascade (GO:2000257)2.69449636
76* vesicle coating (GO:0006901)2.69033208
77glyoxylate metabolic process (GO:0046487)2.68522368
78intestinal cholesterol absorption (GO:0030299)2.68391774
79barbed-end actin filament capping (GO:0051016)2.68343209
80protein carboxylation (GO:0018214)2.67353418
81peptidyl-glutamic acid carboxylation (GO:0017187)2.67353418
82oxaloacetate metabolic process (GO:0006107)2.66283059
83negative regulation of erythrocyte differentiation (GO:0045647)2.64018108
84epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63857829
85nitrogen cycle metabolic process (GO:0071941)2.62826449
86hemidesmosome assembly (GO:0031581)2.62762014
87response to laminar fluid shear stress (GO:0034616)2.62759327
88growth hormone receptor signaling pathway (GO:0060396)2.61960919
89desmosome organization (GO:0002934)2.61489592
90cysteine metabolic process (GO:0006534)2.60513256
91glucocorticoid receptor signaling pathway (GO:0042921)2.60380203
92negative regulation of lipid transport (GO:0032369)2.60082752
93regulation of complement activation (GO:0030449)2.58589604
94regulation of NFAT protein import into nucleus (GO:0051532)2.58560395
95nuclear pore organization (GO:0006999)2.58543643
96mitotic chromosome condensation (GO:0007076)2.57721772
97thymic T cell selection (GO:0045061)2.57176535
98low-density lipoprotein particle clearance (GO:0034383)2.57136832
99negative thymic T cell selection (GO:0045060)2.56849429
100negative T cell selection (GO:0043383)2.54648897
101modulation by symbiont of host cellular process (GO:0044068)2.54514410
102regulation of translational fidelity (GO:0006450)2.54203983
103JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.53784718
104positive regulation of triglyceride biosynthetic process (GO:0010867)2.53080728
105protein export from nucleus (GO:0006611)2.52994752
106regulation of cholesterol storage (GO:0010885)2.52587503
107histone H3-K36 demethylation (GO:0070544)2.52403455
108regulation of extracellular matrix disassembly (GO:0010715)2.51515938
109positive regulation of protein deacetylation (GO:0090312)2.51011396
110pentose-phosphate shunt (GO:0006098)2.50989557
111homocysteine metabolic process (GO:0050667)2.50702071
112positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50518788
113intestinal absorption (GO:0050892)2.50173342
114cellular modified amino acid catabolic process (GO:0042219)2.49999903
115negative regulation of viral release from host cell (GO:1902187)2.49537374
116positive regulation of triglyceride metabolic process (GO:0090208)2.49479755
1173-UTR-mediated mRNA stabilization (GO:0070935)2.49132735
118tryptophan catabolic process (GO:0006569)2.47261289
119indole-containing compound catabolic process (GO:0042436)2.47261289
120indolalkylamine catabolic process (GO:0046218)2.47261289
121membrane protein ectodomain proteolysis (GO:0006509)2.46691625
122apoptotic process involved in morphogenesis (GO:0060561)2.44731122
123regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.44363912
124NIK/NF-kappaB signaling (GO:0038061)2.44129705
125glycine metabolic process (GO:0006544)2.42527181
126high-density lipoprotein particle remodeling (GO:0034375)2.42151475
127regulation of defense response to virus by virus (GO:0050690)2.40847963
128positive regulation of keratinocyte differentiation (GO:0045618)2.40839104
129branching involved in mammary gland duct morphogenesis (GO:0060444)2.39798457
130positive regulation of glycogen biosynthetic process (GO:0045725)2.39787155
131basement membrane organization (GO:0071711)2.39178887
132pore complex assembly (GO:0046931)2.38549011
133intracellular estrogen receptor signaling pathway (GO:0030520)2.38413689
134amino-acid betaine metabolic process (GO:0006577)2.37863972
135phospholipid efflux (GO:0033700)2.36828920
136NADPH regeneration (GO:0006740)2.36413326
137regulation of triglyceride catabolic process (GO:0010896)2.35634999
138dosage compensation (GO:0007549)2.35418247
139semaphorin-plexin signaling pathway (GO:0071526)2.34919136
140cellular response to epidermal growth factor stimulus (GO:0071364)2.34671887
141phospholipid homeostasis (GO:0055091)2.34412128
142signal complex assembly (GO:0007172)2.34134165
143tryptophan metabolic process (GO:0006568)2.33895249
144serine family amino acid catabolic process (GO:0009071)2.33349828
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.32846247
146positive regulation of fatty acid biosynthetic process (GO:0045723)2.31791940
147plasma lipoprotein particle clearance (GO:0034381)2.31313454
148response to endoplasmic reticulum stress (GO:0034976)2.31280101
149regulation of fatty acid oxidation (GO:0046320)2.31119840
150protein-lipid complex assembly (GO:0065005)2.30615382
151reverse cholesterol transport (GO:0043691)2.29891179
152response to muramyl dipeptide (GO:0032495)2.28567806
153epithelial cell-cell adhesion (GO:0090136)2.28260094
154snRNA metabolic process (GO:0016073)2.28038707
155glucose catabolic process (GO:0006007)2.27715812
156surfactant homeostasis (GO:0043129)2.27326340
157regulation of integrin activation (GO:0033623)2.26463598
158regulation of chromatin binding (GO:0035561)2.26055924
159positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.25841196
160amyloid precursor protein catabolic process (GO:0042987)2.24426491
161positive regulation of blood vessel endothelial cell migration (GO:0043536)2.23459934
162negative regulation of protein localization to plasma membrane (GO:1903077)2.23449949
163regulation of mammary gland epithelial cell proliferation (GO:0033599)2.23204259
164hypotonic response (GO:0006971)2.23017137
165negative regulation of fatty acid transport (GO:2000192)2.22942513
166modulation by virus of host process (GO:0019054)2.21438604
167mammary gland epithelial cell proliferation (GO:0033598)2.20810272
168endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.20322394
169protein localization to microtubule (GO:0035372)2.19734613
170cortical actin cytoskeleton organization (GO:0030866)2.19555287
171germinal center formation (GO:0002467)2.19399824
172cell adhesion mediated by integrin (GO:0033627)2.19079137
173NADH metabolic process (GO:0006734)2.18421907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.51644739
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.33201456
3MYC_22102868_ChIP-Seq_BL_Human3.32021510
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.30257884
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.24176543
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.17165859
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.68444365
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.60344115
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.45553646
10CLOCK_20551151_ChIP-Seq_293T_Human2.30808169
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18571803
12VDR_21846776_ChIP-Seq_THP-1_Human2.12355907
13GATA1_22025678_ChIP-Seq_K562_Human2.01633119
14TCF7_22412390_ChIP-Seq_EML_Mouse2.00180421
15E2F7_22180533_ChIP-Seq_HELA_Human1.93211193
16TP63_17297297_ChIP-ChIP_HaCaT_Human1.89130578
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86994391
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.86457913
19KDM2B_26808549_Chip-Seq_DND41_Human1.83313066
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81593099
21MAF_26560356_Chip-Seq_TH1_Human1.79003814
22UTX_26944678_Chip-Seq_JUKART_Human1.78663473
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.75516970
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75471799
25ZNF263_19887448_ChIP-Seq_K562_Human1.72417578
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72281296
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68912945
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.66042628
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65489896
30LXR_22292898_ChIP-Seq_THP-1_Human1.62207389
31* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61071080
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58201300
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58087005
34* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57762611
35* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55083733
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52461414
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50328675
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47231064
39RACK7_27058665_Chip-Seq_MCF-7_Human1.44880608
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44384064
41CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42666165
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42170217
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41764194
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38414904
45KDM2B_26808549_Chip-Seq_K562_Human1.38331681
46MYB_26560356_Chip-Seq_TH1_Human1.37998816
47MYB_26560356_Chip-Seq_TH2_Human1.37208583
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35161706
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35147458
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33430143
51ATF3_27146783_Chip-Seq_COLON_Human1.33082679
52FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.32877315
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32761533
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31887029
55VDR_24763502_ChIP-Seq_THP-1_Human1.31563782
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30665472
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30226806
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.30116500
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29777635
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29452997
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28588191
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27813673
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27326217
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26581516
65CIITA_25753668_ChIP-Seq_RAJI_Human1.26500669
66NCOR1_26117541_ChIP-Seq_K562_Human1.26463929
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26370201
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26133644
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25311596
70* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24251843
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23055571
72GATA6_25053715_ChIP-Seq_YYC3_Human1.21982574
73* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21009905
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19523036
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19107933
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16948502
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.16410511
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16351415
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16167399
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15324492
81RUNX_20019798_ChIP-Seq_JUKART_Human1.15191739
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14712745
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14708974
84* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14152720
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13775391
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.12770433
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11638890
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11204862
89TFEB_21752829_ChIP-Seq_HELA_Human1.10795586
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09440618
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09081878
92GATA1_19941826_ChIP-Seq_K562_Human1.08117399
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.07841557
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07559900
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.07249257
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.06757145
97* MAF_26560356_Chip-Seq_TH2_Human1.06705491
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06028354
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.05892925
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04025397
101STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04002917
102* CHD1_26751641_Chip-Seq_LNCaP_Human1.03797524
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.03666278
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.03282717
105SCL_19346495_ChIP-Seq_HPC-7_Human1.03214183
106TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02558042
107* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01450456
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01303711
109SPI1_23127762_ChIP-Seq_K562_Human1.01140578
110CREB1_26743006_Chip-Seq_LNCaP_Human1.00953897
111SMC4_20622854_ChIP-Seq_HELA_Human1.00899939
112ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00873947
113FOXA2_19822575_ChIP-Seq_HepG2_Human1.00620660
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99870335
115P68_20966046_ChIP-Seq_HELA_Human0.98614771
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98361072
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97898137
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97868901
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.97402627
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.97402627
121RUNX1_27514584_Chip-Seq_MCF-7_Human0.96675291
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95669977
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95583396
124KDM5A_27292631_Chip-Seq_BREAST_Human0.94324995
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93968119
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93625634
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93308164
128GATA3_27048872_Chip-Seq_THYMUS_Human0.92769087
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92602246
130HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91541188
131SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90616509
132HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90204307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.40633138
2MP0002139_abnormal_hepatobiliary_system3.40431321
3MP0005360_urolithiasis3.39017526
4MP0005365_abnormal_bile_salt3.20244846
5MP0003705_abnormal_hypodermis_morpholog3.14000004
6MP0003300_gastrointestinal_ulcer2.71419346
7MP0005085_abnormal_gallbladder_physiolo2.39476947
8MP0003252_abnormal_bile_duct2.38796123
9MP0009840_abnormal_foam_cell2.31277450
10MP0008260_abnormal_autophagy2.25238097
11MP0008438_abnormal_cutaneous_collagen2.18128909
12MP0010234_abnormal_vibrissa_follicle2.08612007
13MP0003091_abnormal_cell_migration2.05366993
14MP0004264_abnormal_extraembryonic_tissu2.04230406
15MP0000537_abnormal_urethra_morphology1.97797907
16MP0010352_gastrointestinal_tract_polyps1.94798321
17MP0001666_abnormal_nutrient_absorption1.88019662
18MP0010329_abnormal_lipoprotein_level1.87533295
19MP0003806_abnormal_nucleotide_metabolis1.81838830
20MP0005076_abnormal_cell_differentiation1.80907505
21MP0003453_abnormal_keratinocyte_physiol1.76392841
22MP0008961_abnormal_basal_metabolism1.74011250
23MP0002796_impaired_skin_barrier1.74003459
24MP0003566_abnormal_cell_adhesion1.68486194
25MP0002166_altered_tumor_susceptibility1.66724847
26MP0000609_abnormal_liver_physiology1.66234252
27MP0002877_abnormal_melanocyte_morpholog1.56174884
28MP0008875_abnormal_xenobiotic_pharmacok1.55506467
29MP0001348_abnormal_lacrimal_gland1.52237082
30MP0003763_abnormal_thymus_physiology1.50714306
31MP0000685_abnormal_immune_system1.47616458
32MP0002138_abnormal_hepatobiliary_system1.45254957
33MP0005083_abnormal_biliary_tract1.44235337
34MP0003191_abnormal_cellular_cholesterol1.41658040
35MP0004947_skin_inflammation1.35751993
36MP0000678_abnormal_parathyroid_gland1.32244854
37MP0009643_abnormal_urine_homeostasis1.29935999
38MP0005220_abnormal_exocrine_pancreas1.29899630
39MP0005409_darkened_coat_color1.29689217
40MP0005501_abnormal_skin_physiology1.28965611
41MP0006054_spinal_hemorrhage1.28015433
42MP0003436_decreased_susceptibility_to1.27324519
43MP0002060_abnormal_skin_morphology1.26726374
44MP0003656_abnormal_erythrocyte_physiolo1.26070689
45MP0001849_ear_inflammation1.24980705
46MP0003329_amyloid_beta_deposits1.22713116
47MP0001216_abnormal_epidermal_layer1.20870116
48MP0004858_abnormal_nervous_system1.20546303
49MP0005621_abnormal_cell_physiology1.20258956
50MP0003183_abnormal_peptide_metabolism1.18747565
51MP0005023_abnormal_wound_healing1.17224311
52MP0004272_abnormal_basement_membrane1.12316869
53MP0004185_abnormal_adipocyte_glucose1.11672173
54MP0003868_abnormal_feces_composition1.11176920
55MP0000598_abnormal_liver_morphology1.10779843
56MP0005319_abnormal_enzyme/_coenzyme1.09374840
57MP0000003_abnormal_adipose_tissue1.08351219
58MP0002118_abnormal_lipid_homeostasis1.07566010
59MP0010155_abnormal_intestine_physiology1.06773354
60MP0005000_abnormal_immune_tolerance1.04879274
61MP0004130_abnormal_muscle_cell1.04806331
62MP0005058_abnormal_lysosome_morphology1.03259120
63MP0009278_abnormal_bone_marrow1.02844052
64MP0002396_abnormal_hematopoietic_system1.01379420
65MP0005332_abnormal_amino_acid1.01374301
66MP0005666_abnormal_adipose_tissue1.00349153
67MP0005375_adipose_tissue_phenotype0.98573124
68MP0001873_stomach_inflammation0.98368942
69MP0001790_abnormal_immune_system0.97699112
70MP0005387_immune_system_phenotype0.97699112
71MP0003221_abnormal_cardiomyocyte_apopto0.97097984
72MP0005257_abnormal_intraocular_pressure0.96994041
73MP0002419_abnormal_innate_immunity0.96938266
74MP0003111_abnormal_nucleus_morphology0.96723115
75MP0009931_abnormal_skin_appearance0.96406133
76MP0002998_abnormal_bone_remodeling0.95318422
77MP0005025_abnormal_response_to0.94054224
78MP0004782_abnormal_surfactant_physiolog0.93657940
79MP0001800_abnormal_humoral_immune0.93324832
80MP0001756_abnormal_urination0.93204486
81MP0000490_abnormal_crypts_of0.92945330
82MP0002006_tumorigenesis0.92650624
83MP0001944_abnormal_pancreas_morphology0.92433794
84MP0009672_abnormal_birth_weight0.92304119
85MP0000013_abnormal_adipose_tissue0.91538064
86MP0001533_abnormal_skeleton_physiology0.90841466
87MP0003303_peritoneal_inflammation0.89619845
88MP0001853_heart_inflammation0.87830384
89MP0005623_abnormal_meninges_morphology0.87402503
90MP0002080_prenatal_lethality0.87350441
91MP0002896_abnormal_bone_mineralization0.87311731
92MP0000350_abnormal_cell_proliferation0.87227430
93MP0002398_abnormal_bone_marrow0.86952094
94MP0003283_abnormal_digestive_organ0.86145836
95MP0000467_abnormal_esophagus_morphology0.85124260
96MP0004808_abnormal_hematopoietic_stem0.84807560
97MP0001730_embryonic_growth_arrest0.84552161
98MP0003195_calcinosis0.84086173
99MP0001845_abnormal_inflammatory_respons0.83904779
100MP0004197_abnormal_fetal_growth/weight/0.83904317
101MP0009333_abnormal_splenocyte_physiolog0.83538910
102MP0010368_abnormal_lymphatic_system0.83266792
103MP0005464_abnormal_platelet_physiology0.83133696
104MP0002086_abnormal_extraembryonic_tissu0.81677885
105MP0005384_cellular_phenotype0.81149307
106MP0002088_abnormal_embryonic_growth/wei0.80835791
107MP0002089_abnormal_postnatal_growth/wei0.80305809
108MP0000767_abnormal_smooth_muscle0.80166459
109MP0009384_cardiac_valve_regurgitation0.80037777
110MP0003567_abnormal_fetal_cardiomyocyte0.79611500
111MP0001835_abnormal_antigen_presentation0.79555478
112MP0002452_abnormal_antigen_presenting0.79528285
113MP0000703_abnormal_thymus_morphology0.79377465
114MP0001819_abnormal_immune_cell0.79157462
115MP0005670_abnormal_white_adipose0.79105069
116MP0002420_abnormal_adaptive_immunity0.78933387
117MP0003448_altered_tumor_morphology0.78904423
118MP0000377_abnormal_hair_follicle0.78888436
119MP0002078_abnormal_glucose_homeostasis0.78837872
120MP0003866_abnormal_defecation0.78674485
121MP0000604_amyloidosis0.78639368
122MP0003984_embryonic_growth_retardation0.78629387
123MP0001958_emphysema0.78332919
124MP0002723_abnormal_immune_serum0.78328817
125MP0010630_abnormal_cardiac_muscle0.76743412
126MP0005380_embryogenesis_phenotype0.76739833
127MP0001672_abnormal_embryogenesis/_devel0.76739833
128MP0002098_abnormal_vibrissa_morphology0.76199932
129MP0010307_abnormal_tumor_latency0.75196925
130MP0004510_myositis0.75113711
131MP0002269_muscular_atrophy0.74631390
132MP0005275_abnormal_skin_tensile0.74204774
133MP0002693_abnormal_pancreas_physiology0.74168903
134MP0002254_reproductive_system_inflammat0.74041592
135MP0009053_abnormal_anal_canal0.73898989
136MP0002928_abnormal_bile_duct0.73732990
137MP0002136_abnormal_kidney_physiology0.73305070
138MP0003172_abnormal_lysosome_physiology0.73212013
139MP0002722_abnormal_immune_system0.72713777
140MP0008469_abnormal_protein_level0.72290800
141MP0000716_abnormal_immune_system0.72135800
142MP0005671_abnormal_response_to0.71470228
143MP0000858_altered_metastatic_potential0.71467351
144MP0002970_abnormal_white_adipose0.71102807
145MP0000477_abnormal_intestine_morphology0.70395303
146MP0000689_abnormal_spleen_morphology0.69644700
147MP0001915_intracranial_hemorrhage0.68480647
148MP0002429_abnormal_blood_cell0.68438081
149MP0004233_abnormal_muscle_weight0.68129035
150MP0000733_abnormal_muscle_development0.67986053

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)3.68584348
2Hypoglycemic coma (HP:0001325)3.43674201
3Xanthomatosis (HP:0000991)2.90555540
4Broad face (HP:0000283)2.89770759
5Abnormal gallbladder physiology (HP:0012438)2.87950552
6Cholecystitis (HP:0001082)2.87950552
7Abnormality of monocarboxylic acid metabolism (HP:0010996)2.86020280
8Premature rupture of membranes (HP:0001788)2.85124956
9Intrahepatic cholestasis (HP:0001406)2.82310745
10Vertebral compression fractures (HP:0002953)2.77440158
11Abnormality of the common coagulation pathway (HP:0010990)2.73193141
12Abnormality of aromatic amino acid family metabolism (HP:0004338)2.72862345
13Ankyloglossia (HP:0010296)2.64254623
14Cerebral aneurysm (HP:0004944)2.63079031
15Ketosis (HP:0001946)2.59331375
16Increased connective tissue (HP:0009025)2.58394653
17Distal lower limb amyotrophy (HP:0008944)2.57424736
18Long toe (HP:0010511)2.56249430
19Ketoacidosis (HP:0001993)2.47511597
20Hypoglycemic seizures (HP:0002173)2.44476023
21Mitral stenosis (HP:0001718)2.43935336
22Complement deficiency (HP:0004431)2.42266570
23Abnormality of oral frenula (HP:0000190)2.40891272
24Abnormality of the pancreatic islet cells (HP:0006476)2.40699834
25Abnormality of endocrine pancreas physiology (HP:0012093)2.40699834
26Late onset (HP:0003584)2.40668420
27Hyperacusis (HP:0010780)2.40100430
28Aneurysm (HP:0002617)2.36000977
29Abnormality of the intrinsic pathway (HP:0010989)2.34217378
30Eczematoid dermatitis (HP:0000976)2.31909842
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25866347
32Aortic aneurysm (HP:0004942)2.25696941
33Hypobetalipoproteinemia (HP:0003563)2.25089482
34Hand muscle atrophy (HP:0009130)2.24257869
35Hyperinsulinemic hypoglycemia (HP:0000825)2.21238357
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.18980983
37Esophageal varix (HP:0002040)2.18570625
38Disproportionate tall stature (HP:0001519)2.18460667
39Abnormality of sulfur amino acid metabolism (HP:0004339)2.16314448
40Hyperammonemia (HP:0001987)2.15510458
41Achilles tendon contracture (HP:0001771)2.12726450
42Hyperglycemia (HP:0003074)2.10831177
43Abnormality of the fingertips (HP:0001211)2.10768748
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10633253
45Myocardial infarction (HP:0001658)2.09501597
46Spastic diplegia (HP:0001264)2.08861722
47Autoimmune thrombocytopenia (HP:0001973)2.07623820
48Osteolytic defects of the hand bones (HP:0009699)2.06587497
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.06587497
50Lymphangioma (HP:0100764)2.06582701
51Reticulocytosis (HP:0001923)2.05342375
52Asymmetry of the thorax (HP:0001555)2.02176297
53Insidious onset (HP:0003587)2.01606739
54Termporal pattern (HP:0011008)2.01606739
55Distal upper limb amyotrophy (HP:0007149)2.01525717
56Upper limb amyotrophy (HP:0009129)2.01525717
57Short nail (HP:0001799)2.01188204
58Back pain (HP:0003418)2.00200478
59Abnormality of fatty-acid metabolism (HP:0004359)2.00014478
60Long palpebral fissure (HP:0000637)1.99012082
61Cellulitis (HP:0100658)1.98678959
62Polycythemia (HP:0001901)1.98600331
63Gout (HP:0001997)1.98278689
64Abnormality of the Achilles tendon (HP:0005109)1.97960486
65T lymphocytopenia (HP:0005403)1.97816409
66Colitis (HP:0002583)1.96855482
67Metaphyseal cupping (HP:0003021)1.95293861
68Abnormality of the distal phalanges of the toes (HP:0010182)1.93428803
69Insomnia (HP:0100785)1.91110896
70Arterial tortuosity (HP:0005116)1.90838518
71Abnormality of purine metabolism (HP:0004352)1.90070667
72Protrusio acetabuli (HP:0003179)1.89971173
73Distal lower limb muscle weakness (HP:0009053)1.89693611
74Abnormality of T cell number (HP:0011839)1.88675945
75Thin bony cortex (HP:0002753)1.88481946
76Hyperlipoproteinemia (HP:0010980)1.87793929
77Mucopolysacchariduria (HP:0008155)1.87715004
78Urinary glycosaminoglycan excretion (HP:0003541)1.87715004
79Interstitial pulmonary disease (HP:0006530)1.87527014
80Advanced eruption of teeth (HP:0006288)1.87285582
81Nasal polyposis (HP:0100582)1.87202206
82Fragile skin (HP:0001030)1.86992734
83Ulnar bowing (HP:0003031)1.86406910
84Recurrent viral infections (HP:0004429)1.84079081
85Abnormality of complement system (HP:0005339)1.84009796
86Abnormality of the nasal mucosa (HP:0000433)1.83980272
87Pseudobulbar signs (HP:0002200)1.83640177
88Abnormality of macrophages (HP:0004311)1.83118254
89Myoglobinuria (HP:0002913)1.82059051
90Hepatocellular carcinoma (HP:0001402)1.81139020
91Right ventricular cardiomyopathy (HP:0011663)1.81012240
92Increased IgE level (HP:0003212)1.79678460
93Cerebral inclusion bodies (HP:0100314)1.79567783
94Rectal prolapse (HP:0002035)1.78296035
95Abnormal foot bone ossification (HP:0010675)1.78201665
96Pancreatic islet-cell hyperplasia (HP:0004510)1.78117378
97Mitral valve prolapse (HP:0001634)1.78095597
98Severe short stature (HP:0003510)1.77397636
99Limb hypertonia (HP:0002509)1.77120646
100Flat acetabular roof (HP:0003180)1.77104810
101Dysmetric saccades (HP:0000641)1.76768079
102Insulin resistance (HP:0000855)1.75171162
103Hypolipoproteinemia (HP:0010981)1.74767696
104Hyperglycinuria (HP:0003108)1.74219981
105Hypertensive crisis (HP:0100735)1.73548700
106Upper motor neuron abnormality (HP:0002127)1.73150552
107Abnormality of the thoracic spine (HP:0100711)1.72996713
108Cervical subluxation (HP:0003308)1.72628948
109Symptomatic seizures (HP:0011145)1.72399484
110Obstructive sleep apnea (HP:0002870)1.71715096
111Blue sclerae (HP:0000592)1.71511940
112Vascular tortuosity (HP:0004948)1.71391610
113Spontaneous hematomas (HP:0007420)1.70507153
114Increased density of long bones (HP:0006392)1.69517018
115Abnormality of polysaccharide metabolism (HP:0011012)1.69462752
116Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69462752
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69462752
118Atrophic scars (HP:0001075)1.69374788
119Hematochezia (HP:0002573)1.68399880
120Bone pain (HP:0002653)1.68226849
121Macroorchidism (HP:0000053)1.68198813
122Striae distensae (HP:0001065)1.68146671
123Loss of speech (HP:0002371)1.67808731
124Hypoplasia of the thymus (HP:0000778)1.67156757
125Gastrointestinal inflammation (HP:0004386)1.65893794
126Epidermoid cyst (HP:0200040)1.65869791
127Skin nodule (HP:0200036)1.65075728
128Gastrointestinal stroma tumor (HP:0100723)1.64792536
129Fatigue (HP:0012378)1.64246084
130Hypercholesterolemia (HP:0003124)1.63627377
131Spinal rigidity (HP:0003306)1.63498338
132Sparse lateral eyebrow (HP:0005338)1.63380460
133Cardiomegaly (HP:0001640)1.62933802
134Asymmetric septal hypertrophy (HP:0001670)1.62690082
135Segmental peripheral demyelination/remyelination (HP:0003481)1.62291623
136Dysostosis multiplex (HP:0000943)1.62126321
137Lower limb amyotrophy (HP:0007210)1.61608193
138Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.61607078
139Abnormal ossification of hand bones (HP:0005921)1.61547821
140Trismus (HP:0000211)1.61475112
141Slow saccadic eye movements (HP:0000514)1.61396211
142Natal tooth (HP:0000695)1.61348416
143Subacute progressive viral hepatitis (HP:0006572)1.61147023
144Abnormality of nucleobase metabolism (HP:0010932)1.60538368
145Wormian bones (HP:0002645)1.60444460
146Increased mean platelet volume (HP:0011877)1.59848126
147Papilloma (HP:0012740)1.59772732
148Verrucae (HP:0200043)1.59772732
149Hypoalphalipoproteinemia (HP:0003233)1.59510976
150Flattened epiphyses (HP:0003071)1.59168288
151Patellar dislocation (HP:0002999)1.59098275
152Fat malabsorption (HP:0002630)1.58611981
153J-shaped sella turcica (HP:0002680)1.58556781
154Elfin facies (HP:0004428)1.58507117
155Progressive hearing impairment (HP:0001730)1.58316229
156Abnormality of carpal bone ossification (HP:0006257)1.58115419
157Recurrent bronchitis (HP:0002837)1.57812581
158Bowel incontinence (HP:0002607)1.57245437
159Hemorrhage of the eye (HP:0011885)1.56937875
160Decreased motor nerve conduction velocity (HP:0003431)1.56567281
161Neoplasm of the heart (HP:0100544)1.56464967
162Orthostatic hypotension (HP:0001278)1.56202114
163Cholelithiasis (HP:0001081)1.56067259
164Dilatation of the ascending aorta (HP:0005111)1.56066462
165Renovascular hypertension (HP:0100817)1.55734917
166Thrombocytosis (HP:0001894)1.55652962
167Emphysema (HP:0002097)1.53847708
168Abnormal tarsal ossification (HP:0008369)1.52201598
169Seborrheic dermatitis (HP:0001051)1.52100065
170Abnormality of the acetabulum (HP:0003170)1.51368118
171Abnormality of nail color (HP:0100643)1.51296716
172Neurofibrillary tangles (HP:0002185)1.51158176
173Persistence of primary teeth (HP:0006335)1.50776889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.63813749
2TRIB34.28103744
3PKN23.76421757
4PRPF4B3.49641401
5EEF2K3.25383939
6MAP3K103.10494296
7SMG13.01869307
8SIK12.72912221
9FGFR42.68000742
10MAP4K12.64519779
11IRAK32.47084123
12PTK62.43415873
13PASK1.99547681
14CDK121.92549069
15TTN1.90102703
16MST1R1.89681995
17FLT31.81976708
18RIPK41.75248057
19STK101.62695974
20TAOK31.60845716
21JAK31.59242281
22LRRK21.57487393
23ZAP701.54158668
24TYK21.47756684
25PDGFRA1.46459451
26BCKDK1.46271499
27NME21.45431241
28MAP3K141.43272220
29RIPK11.42730002
30EPHB11.37247493
31LATS11.30021238
32CAMK1G1.25800914
33ICK1.23445929
34MTOR1.21936559
35JAK11.16576472
36ITK1.13536548
37MAP2K31.11662362
38MAP3K71.11365853
39TAOK21.06143366
40FGFR31.06079826
41SCYL21.05222678
42TBK11.03541753
43EPHA31.03244845
44CDK41.01624971
45PTK20.98427026
46EIF2AK10.97845350
47GRK60.97135029
48CDK60.96339323
49JAK20.95710067
50PRKD20.95390428
51CAMK1D0.95288709
52LMTK20.94744320
53SIK20.91159810
54CDC42BPA0.90422352
55BTK0.90110057
56NEK20.86674196
57KDR0.85552167
58MARK20.84986370
59PAK40.84899169
60SIK30.82465144
61PDPK10.82107033
62MAPKAPK30.81913729
63MAP3K20.79404855
64MAPK110.78482141
65CSK0.78326457
66LATS20.75591911
67RPS6KB20.75083194
68PDGFRB0.74619155
69PRKCH0.73069014
70BRD40.73044781
71PAK20.72102076
72TGFBR10.71338673
73RET0.70659346
74ALK0.70423162
75MAPK150.70227045
76IRAK40.68107824
77ARAF0.67852696
78STK30.66075764
79CLK10.65913949
80DYRK1B0.65702512
81NTRK10.64888595
82TGFBR20.64027127
83FGFR10.63870749
84DDR20.63805843
85TAOK10.62896018
86CHUK0.62569402
87INSRR0.62552144
88RAF10.62140331
89CSF1R0.61357189
90MAP3K80.60113439
91STK380.59042221
92FRK0.58291502
93TESK10.57834711
94EPHA20.55628968
95PDK10.55560292
96MAP3K60.54630834
97HIPK20.54421318
98KIT0.52936625
99ERBB20.52163008
100KSR10.51231337
101RPS6KA20.50464001
102CDK70.50313170
103PRKD30.50128808
104BLK0.47557620
105DMPK0.47012972
106MAP3K10.46847886
107MAP3K30.46274121
108IKBKE0.46152898
109TYRO30.45873220
110RPS6KA40.45437562
111FGR0.43727581
112MAP3K130.42854027
113HCK0.41191644
114BMX0.41158045
115MOS0.40535841
116LCK0.40093321
117MAP2K20.39795230
118PIK3CG0.39408329
119TESK20.39285291
120TRPM70.39028835
121MAP3K90.37324143
122SYK0.35968837
123CDK90.35792951
124EGFR0.34741512
125YES10.34661400
126ILK0.34048856
127NEK90.33590581
128TXK0.33470790
129KSR20.33434775
130MAPKAPK20.33026164
131IRAK20.33020377
132RPS6KC10.32559742
133MARK30.31776706
134PAK30.31427266
135NEK10.31331455
136PRKD10.29475200
137MET0.28324643
138PRKAA10.28323998
139RPS6KA10.28263261

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.84275047
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.53396083
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47611774
4Nitrogen metabolism_Homo sapiens_hsa009102.35948828
5Fatty acid degradation_Homo sapiens_hsa000712.27172846
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.24943564
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20165484
8Selenocompound metabolism_Homo sapiens_hsa004502.08734625
9Tryptophan metabolism_Homo sapiens_hsa003802.04865594
10Lysine degradation_Homo sapiens_hsa003101.88982425
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78424768
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76333169
13Arginine biosynthesis_Homo sapiens_hsa002201.73447787
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69453861
15VEGF signaling pathway_Homo sapiens_hsa043701.59661793
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59438388
17Fatty acid metabolism_Homo sapiens_hsa012121.58045713
18* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57261478
19Complement and coagulation cascades_Homo sapiens_hsa046101.55939069
20Thyroid cancer_Homo sapiens_hsa052161.50306769
21Insulin resistance_Homo sapiens_hsa049311.50294606
22Fat digestion and absorption_Homo sapiens_hsa049751.47084295
23Renal cell carcinoma_Homo sapiens_hsa052111.47022311
24Fructose and mannose metabolism_Homo sapiens_hsa000511.46902392
25Caffeine metabolism_Homo sapiens_hsa002321.46509631
26PPAR signaling pathway_Homo sapiens_hsa033201.39503619
27Staphylococcus aureus infection_Homo sapiens_hsa051501.22770494
28Chronic myeloid leukemia_Homo sapiens_hsa052201.22650340
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20469556
30Primary immunodeficiency_Homo sapiens_hsa053401.20103138
31Shigellosis_Homo sapiens_hsa051311.19103344
32Biosynthesis of amino acids_Homo sapiens_hsa012301.18636407
33Prion diseases_Homo sapiens_hsa050201.18410287
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17129025
35ABC transporters_Homo sapiens_hsa020101.15918833
36Carbon metabolism_Homo sapiens_hsa012001.15484499
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15253830
38Propanoate metabolism_Homo sapiens_hsa006401.15007968
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14670759
40ErbB signaling pathway_Homo sapiens_hsa040121.13071010
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08667299
42Glioma_Homo sapiens_hsa052141.07821896
43Antigen processing and presentation_Homo sapiens_hsa046121.07298928
44One carbon pool by folate_Homo sapiens_hsa006701.05167315
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02013020
46Viral myocarditis_Homo sapiens_hsa054161.01435828
47Prostate cancer_Homo sapiens_hsa052151.01249169
48Starch and sucrose metabolism_Homo sapiens_hsa005001.00130531
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.99422395
50Acute myeloid leukemia_Homo sapiens_hsa052210.99275705
51Bile secretion_Homo sapiens_hsa049760.96887639
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.95300721
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94171342
54TNF signaling pathway_Homo sapiens_hsa046680.94096513
55Pyruvate metabolism_Homo sapiens_hsa006200.93121792
56HIF-1 signaling pathway_Homo sapiens_hsa040660.91120987
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90835686
58T cell receptor signaling pathway_Homo sapiens_hsa046600.90194842
59Butanoate metabolism_Homo sapiens_hsa006500.90078990
60Inositol phosphate metabolism_Homo sapiens_hsa005620.89610216
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89253053
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89180224
63mTOR signaling pathway_Homo sapiens_hsa041500.88557626
64Toxoplasmosis_Homo sapiens_hsa051450.88156126
65MicroRNAs in cancer_Homo sapiens_hsa052060.87438111
66Pancreatic cancer_Homo sapiens_hsa052120.85712970
67Amoebiasis_Homo sapiens_hsa051460.84526100
68Endocytosis_Homo sapiens_hsa041440.82875021
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82849854
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.82167107
71Insulin signaling pathway_Homo sapiens_hsa049100.81825808
72Notch signaling pathway_Homo sapiens_hsa043300.80783568
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.80681768
74Vibrio cholerae infection_Homo sapiens_hsa051100.80235206
75Peroxisome_Homo sapiens_hsa041460.80102786
76Choline metabolism in cancer_Homo sapiens_hsa052310.79331427
77beta-Alanine metabolism_Homo sapiens_hsa004100.79227128
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78749698
79Small cell lung cancer_Homo sapiens_hsa052220.76699826
80GnRH signaling pathway_Homo sapiens_hsa049120.76276074
81B cell receptor signaling pathway_Homo sapiens_hsa046620.76204823
82Type II diabetes mellitus_Homo sapiens_hsa049300.75813023
83Adherens junction_Homo sapiens_hsa045200.75048943
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.74559911
85Galactose metabolism_Homo sapiens_hsa000520.74173733
86AMPK signaling pathway_Homo sapiens_hsa041520.73690572
87Estrogen signaling pathway_Homo sapiens_hsa049150.73545564
88Pentose phosphate pathway_Homo sapiens_hsa000300.73541247
89Histidine metabolism_Homo sapiens_hsa003400.73381770
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73077781
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72527374
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.72307415
93Prolactin signaling pathway_Homo sapiens_hsa049170.71882094
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71177084
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71090641
96Endometrial cancer_Homo sapiens_hsa052130.70915693
97Legionellosis_Homo sapiens_hsa051340.70671912
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70670775
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70445538
100Epstein-Barr virus infection_Homo sapiens_hsa051690.69950654
101Salmonella infection_Homo sapiens_hsa051320.69649872
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69269084
103Glucagon signaling pathway_Homo sapiens_hsa049220.69183621
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.68662984
105Tuberculosis_Homo sapiens_hsa051520.67988306
106Measles_Homo sapiens_hsa051620.66706588
107N-Glycan biosynthesis_Homo sapiens_hsa005100.66066796
108Osteoclast differentiation_Homo sapiens_hsa043800.65973543
109Phenylalanine metabolism_Homo sapiens_hsa003600.65264400
110Proteoglycans in cancer_Homo sapiens_hsa052050.63552098
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62426339
112Glycerolipid metabolism_Homo sapiens_hsa005610.62116804
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60593726
114Leishmaniasis_Homo sapiens_hsa051400.60443151
115Apoptosis_Homo sapiens_hsa042100.59509895
116Focal adhesion_Homo sapiens_hsa045100.59425856
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.59157059
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59055220
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58791844
120Non-small cell lung cancer_Homo sapiens_hsa052230.57774388
121Hepatitis B_Homo sapiens_hsa051610.57418159
122Chemokine signaling pathway_Homo sapiens_hsa040620.56620290
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.56236763
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.55638784
125Bladder cancer_Homo sapiens_hsa052190.55510387
126Sulfur metabolism_Homo sapiens_hsa009200.53392060
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.52511441
128Lysosome_Homo sapiens_hsa041420.52016897
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51067020
130Colorectal cancer_Homo sapiens_hsa052100.50647757
131Platelet activation_Homo sapiens_hsa046110.50371882
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.50088283
133mRNA surveillance pathway_Homo sapiens_hsa030150.49397787
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48585217
135Influenza A_Homo sapiens_hsa051640.48520884
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48517763
137HTLV-I infection_Homo sapiens_hsa051660.48114090
138Herpes simplex infection_Homo sapiens_hsa051680.47956754
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47721694
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47290419
141ECM-receptor interaction_Homo sapiens_hsa045120.47040749
142Hepatitis C_Homo sapiens_hsa051600.46580802
143Viral carcinogenesis_Homo sapiens_hsa052030.45683697

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