SEC24D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. This gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Mutations in this gene have been associated with Cole-Carpenter syndrome, a disorder affecting bone formation, resulting in craniofacial malformations and bones that break easily. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.26151585
2Golgi transport vesicle coating (GO:0048200)7.26151585
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.95234209
4protein retention in ER lumen (GO:0006621)5.40109998
5cell adhesion mediated by integrin (GO:0033627)5.04775222
6* COPII vesicle coating (GO:0048208)4.89914472
7endodermal cell differentiation (GO:0035987)4.87537487
8L-phenylalanine catabolic process (GO:0006559)4.65091643
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.65091643
10sequestering of extracellular ligand from receptor (GO:0035581)4.54113550
11chondrocyte proliferation (GO:0035988)4.43378237
12L-phenylalanine metabolic process (GO:0006558)4.43251887
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.43251887
14intestinal cholesterol absorption (GO:0030299)4.37609450
15protein carboxylation (GO:0018214)4.31788243
16peptidyl-glutamic acid carboxylation (GO:0017187)4.31788243
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.25247294
18activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.22908187
19positive regulation of nuclease activity (GO:0032075)4.00875155
20negative regulation of fibrinolysis (GO:0051918)3.94723927
21wound healing, spreading of epidermal cells (GO:0035313)3.89848396
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.83473522
23exocrine pancreas development (GO:0031017)3.81017330
244-hydroxyproline metabolic process (GO:0019471)3.80113480
25aromatic amino acid family catabolic process (GO:0009074)3.76317305
26endoplasmic reticulum unfolded protein response (GO:0030968)3.72245807
27regulation of fibrinolysis (GO:0051917)3.64194701
28complement activation, alternative pathway (GO:0006957)3.60892204
29regulation of nuclease activity (GO:0032069)3.60395856
30cellular response to unfolded protein (GO:0034620)3.60360106
31collagen metabolic process (GO:0032963)3.59975479
32homocysteine metabolic process (GO:0050667)3.53664702
33regulation of protein activation cascade (GO:2000257)3.53447159
34intestinal absorption (GO:0050892)3.50587998
35ER-nucleus signaling pathway (GO:0006984)3.48234237
36sulfur amino acid catabolic process (GO:0000098)3.47480277
37alpha-linolenic acid metabolic process (GO:0036109)3.45742507
38multicellular organismal macromolecule metabolic process (GO:0044259)3.44383394
39regulation of cholesterol homeostasis (GO:2000188)3.41339624
40positive regulation of endothelial cell apoptotic process (GO:2000353)3.39840642
41cellular response to topologically incorrect protein (GO:0035967)3.39502467
42collagen catabolic process (GO:0030574)3.39425088
43regulation of complement activation (GO:0030449)3.38995681
44blood vessel maturation (GO:0001955)3.37575135
45virion attachment to host cell (GO:0019062)3.37326928
46adhesion of symbiont to host cell (GO:0044650)3.37326928
47basement membrane organization (GO:0071711)3.36300644
48cell migration involved in heart development (GO:0060973)3.35809738
49multicellular organismal metabolic process (GO:0044236)3.35078623
50substrate-dependent cell migration (GO:0006929)3.33245953
51cellular response to vitamin (GO:0071295)3.30811576
52multicellular organismal catabolic process (GO:0044243)3.30153605
53* vesicle coating (GO:0006901)3.29473293
54chondrocyte development (GO:0002063)3.25638980
55high-density lipoprotein particle remodeling (GO:0034375)3.24850452
56extracellular matrix disassembly (GO:0022617)3.23485244
57cysteine metabolic process (GO:0006534)3.22238406
58acylglycerol homeostasis (GO:0055090)3.22103050
59triglyceride homeostasis (GO:0070328)3.22103050
60endocrine pancreas development (GO:0031018)3.20174904
61positive regulation of fatty acid beta-oxidation (GO:0032000)3.19021199
62regulation of extracellular matrix disassembly (GO:0010715)3.19002709
63kynurenine metabolic process (GO:0070189)3.18320131
64signal peptide processing (GO:0006465)3.17778505
65lipoprotein metabolic process (GO:0042157)3.16547596
66hypotonic response (GO:0006971)3.16392628
67peptide hormone processing (GO:0016486)3.16325263
68hyaluronan catabolic process (GO:0030214)3.15717319
69nucleotide-sugar biosynthetic process (GO:0009226)3.14516298
70regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.13870885
71regulation of triglyceride catabolic process (GO:0010896)3.13840962
72glyoxylate metabolic process (GO:0046487)3.12927134
73lysine metabolic process (GO:0006553)3.12429326
74lysine catabolic process (GO:0006554)3.12429326
75bone trabecula formation (GO:0060346)3.12080768
76sequestering of metal ion (GO:0051238)3.10650518
77collagen fibril organization (GO:0030199)3.10601527
78bile acid biosynthetic process (GO:0006699)3.09574367
79urea metabolic process (GO:0019627)3.07047799
80urea cycle (GO:0000050)3.07047799
81ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.06357979
82reverse cholesterol transport (GO:0043691)3.06185963
83response to endoplasmic reticulum stress (GO:0034976)3.05574484
84protein localization to endosome (GO:0036010)3.05247615
85cell migration involved in sprouting angiogenesis (GO:0002042)3.04213826
86tryptophan metabolic process (GO:0006568)3.03570645
87plasma lipoprotein particle clearance (GO:0034381)3.03376591
88epoxygenase P450 pathway (GO:0019373)3.02889567
89adhesion of symbiont to host (GO:0044406)3.02025461
90wound healing, spreading of cells (GO:0044319)3.01634469
91keratan sulfate catabolic process (GO:0042340)3.01416967
92skin morphogenesis (GO:0043589)3.01006963
93tryptophan catabolic process (GO:0006569)3.00766066
94indole-containing compound catabolic process (GO:0042436)3.00766066
95indolalkylamine catabolic process (GO:0046218)3.00766066
96positive regulation of fatty acid biosynthetic process (GO:0045723)2.98111449
97low-density lipoprotein particle clearance (GO:0034383)2.97893583
98endocardial cushion development (GO:0003197)2.96147325
99UDP-N-acetylglucosamine metabolic process (GO:0006047)2.94714535
100cell-substrate junction assembly (GO:0007044)2.93945317
101fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.93920721
102regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.93753491
103positive regulation of blood vessel endothelial cell migration (GO:0043536)2.92827691
104regulation of plasminogen activation (GO:0010755)2.91284571
105extracellular fibril organization (GO:0043206)2.90666971
106tyrosine metabolic process (GO:0006570)2.89909577
107positive regulation of glycolytic process (GO:0045821)2.89585263
108fibrinolysis (GO:0042730)2.89487684
109regulation of transforming growth factor beta1 production (GO:0032908)2.89407113
110negative regulation of fatty acid transport (GO:2000192)2.89071052
111negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.89063666
112apoptotic cell clearance (GO:0043277)2.88575847
113hormone catabolic process (GO:0042447)2.87427775
114kidney mesenchyme development (GO:0072074)2.87353961
115protein maturation by protein folding (GO:0022417)2.86928894
116L-alpha-amino acid transmembrane transport (GO:1902475)2.86074914
117smooth muscle tissue development (GO:0048745)2.85937025
118cellular modified amino acid catabolic process (GO:0042219)2.85894460
119vascular endothelial growth factor signaling pathway (GO:0038084)2.85605166
120regulation of fatty acid beta-oxidation (GO:0031998)2.83751612
121fibril organization (GO:0097435)2.82512225
122extracellular matrix assembly (GO:0085029)2.82354787
123response to unfolded protein (GO:0006986)2.82307978
124endothelial cell morphogenesis (GO:0001886)2.81996793
125mesenchymal-epithelial cell signaling (GO:0060638)2.81518829
126cellular response to vitamin D (GO:0071305)2.81366408
127valine metabolic process (GO:0006573)2.81084769
128positive regulation of fatty acid oxidation (GO:0046321)2.80793490
129heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.80764926
130substrate adhesion-dependent cell spreading (GO:0034446)2.79081187
131protein-lipid complex remodeling (GO:0034368)2.78968013
132macromolecular complex remodeling (GO:0034367)2.78968013
133plasma lipoprotein particle remodeling (GO:0034369)2.78968013
134bile acid metabolic process (GO:0008206)2.78846672
135bile acid and bile salt transport (GO:0015721)2.78233952
136nitrogen cycle metabolic process (GO:0071941)2.78028573
137phospholipid efflux (GO:0033700)2.77402805
138regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.75860054
139regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.75484082
140extracellular regulation of signal transduction (GO:1900115)2.74855386
141extracellular negative regulation of signal transduction (GO:1900116)2.74855386
142hemidesmosome assembly (GO:0031581)2.74257869
143cellular glucuronidation (GO:0052695)2.73574114
144stress fiber assembly (GO:0043149)2.73092219
145positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.72186042
146response to topologically incorrect protein (GO:0035966)2.71724008
147peptidyl-proline hydroxylation (GO:0019511)2.71601705
148protein heterotrimerization (GO:0070208)2.70346932
149positive regulation of extracellular matrix organization (GO:1903055)2.70202083
150positive regulation of lipid catabolic process (GO:0050996)2.69562009
151retina vasculature morphogenesis in camera-type eye (GO:0061299)2.69167260
152negative regulation of chondrocyte differentiation (GO:0032331)2.69017504
153positive regulation of fatty acid metabolic process (GO:0045923)2.68523177
154ER overload response (GO:0006983)2.67822696
155coenzyme catabolic process (GO:0009109)2.67318081
156glomerular basement membrane development (GO:0032836)2.67192907
157positive regulation of osteoblast proliferation (GO:0033690)2.67036671
158aromatic amino acid family metabolic process (GO:0009072)2.66470085
159mesodermal cell differentiation (GO:0048333)2.63985078
160extracellular matrix organization (GO:0030198)2.63976681
161extracellular structure organization (GO:0043062)2.63015263
162type B pancreatic cell proliferation (GO:0044342)2.61354212
163protein hydroxylation (GO:0018126)2.60392068
164membrane raft organization (GO:0031579)2.60197441
165pinocytosis (GO:0006907)2.60136246
166cholesterol efflux (GO:0033344)2.59381591
167glomerular visceral epithelial cell development (GO:0072015)2.56529197
168sprouting angiogenesis (GO:0002040)2.55108003
169pericardium development (GO:0060039)2.53657769
170negative regulation of smooth muscle cell migration (GO:0014912)2.52567366
171barbed-end actin filament capping (GO:0051016)2.49082193
172regulation of endothelial cell apoptotic process (GO:2000351)2.47784813
173positive regulation of fibroblast migration (GO:0010763)2.47783763
174negative regulation of protein localization to plasma membrane (GO:1903077)2.47380909
175regulation of transforming growth factor beta2 production (GO:0032909)2.45384550
176platelet-derived growth factor receptor signaling pathway (GO:0048008)2.45382992
177lymphangiogenesis (GO:0001946)2.45035081
178metanephric mesenchyme development (GO:0072075)2.44964856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.46608626
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.53967224
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.84563974
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.65674979
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.16560560
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.98084520
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.73462892
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64320463
9CLOCK_20551151_ChIP-Seq_293T_Human3.47256624
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.42769955
11TP63_17297297_ChIP-ChIP_HaCaT_Human3.30046723
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11869703
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.11816255
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.11356747
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.94590853
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.91450074
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.52948775
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43590504
19GATA1_22025678_ChIP-Seq_K562_Human2.29360467
20* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.11054648
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.98286703
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97596197
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95889640
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95047011
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.86669145
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.84315844
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81981374
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69417641
29TP53_18474530_ChIP-ChIP_U2OS_Human1.60370037
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59928093
31TP53_16413492_ChIP-PET_HCT116_Human1.56384489
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.52840057
33* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52800833
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.52359968
35* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51676217
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50556849
37* SOX2_20726797_ChIP-Seq_SW620_Human1.48363006
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47008186
39* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46329768
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.43063183
41GATA4_25053715_ChIP-Seq_YYC3_Human1.42045041
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39101658
43* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38931737
44* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38931737
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37196678
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34227663
47* CJUN_26792858_Chip-Seq_BT549_Human1.32844264
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32794944
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32068397
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31046389
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.29364225
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.26771085
53TBX20_22328084_ChIP-Seq_HEART_Mouse1.26771085
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26267471
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.23986742
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.19764729
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17792171
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16829830
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16531269
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16409403
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16113188
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15073084
63EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.13950926
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13388148
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13099784
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12329098
67* ATF3_27146783_Chip-Seq_COLON_Human1.12071628
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11979311
69BRD4_25478319_ChIP-Seq_HGPS_Human1.11758551
70RACK7_27058665_Chip-Seq_MCF-7_Human1.10945913
71GATA6_25053715_ChIP-Seq_YYC3_Human1.10933160
72AHR_22903824_ChIP-Seq_MCF-7_Human1.10236661
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09509459
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08723235
75FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06071268
76* HNF4A_19822575_ChIP-Seq_HepG2_Human1.05019276
77TP53_22127205_ChIP-Seq_IMR90_Human1.04178475
78GATA3_24758297_ChIP-Seq_MCF-7_Human1.03548797
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.03540167
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.00840121
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00215401
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99926885
83LXR_22292898_ChIP-Seq_THP-1_Human0.99903100
84GATA2_21666600_ChIP-Seq_HMVEC_Human0.99708717
85FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99338298
86P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98513724
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98506071
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97882540
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97502261
90TCF4_18268006_ChIP-ChIP_LS174T_Human0.96256829
91NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95768303
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95203331
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95182186
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94958396
95SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94615891
96* WT1_19549856_ChIP-ChIP_CCG9911_Human0.94491175
97* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94296885
98ELK3_25401928_ChIP-Seq_HUVEC_Human0.94215060
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93108461
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93101574
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93101574
102SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92026273
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91899214
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.90137568
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89584153
106VDR_24787735_ChIP-Seq_THP-1_Human0.88869557
107AR_21909140_ChIP-Seq_LNCAP_Human0.88563252
108PIAS1_25552417_ChIP-Seq_VCAP_Human0.88541084
109IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87987946
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87945902
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87870548
112CDX2_22108803_ChIP-Seq_LS180_Human0.87270646
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86175858
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84924791
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84280792
116* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84277904
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84238083
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.83975174
119FOXA1_25552417_ChIP-Seq_VCAP_Human0.83705008
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76393506
121ZNF263_19887448_ChIP-Seq_K562_Human0.76221389
122FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.73813473
123TP63_23658742_ChIP-Seq_EP156T_Human0.73584191
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73413387
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72849514
126MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.72627705
127* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72156711
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.71812652
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71353041

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.58409603
2MP0002139_abnormal_hepatobiliary_system4.53394283
3MP0005360_urolithiasis4.06508979
4MP0005365_abnormal_bile_salt3.66371344
5MP0005085_abnormal_gallbladder_physiolo3.28076099
6MP0003705_abnormal_hypodermis_morpholog3.11098392
7MP0003252_abnormal_bile_duct2.92136513
8MP0005275_abnormal_skin_tensile2.81309479
9MP0003195_calcinosis2.72293371
10MP0005503_abnormal_tendon_morphology2.57047287
11MP0002877_abnormal_melanocyte_morpholog2.54227950
12MP0003950_abnormal_plasma_membrane2.40954935
13MP0001666_abnormal_nutrient_absorption2.37813997
14MP0006054_spinal_hemorrhage2.32559933
15MP0003283_abnormal_digestive_organ2.25177213
16MP0008875_abnormal_xenobiotic_pharmacok2.17227590
17MP0000013_abnormal_adipose_tissue2.15345856
18MP0003941_abnormal_skin_development2.11783055
19MP0005083_abnormal_biliary_tract2.10120962
20MP0005220_abnormal_exocrine_pancreas2.10096127
21MP0003806_abnormal_nucleotide_metabolis1.98528174
22MP0009780_abnormal_chondrocyte_physiolo1.98124380
23MP0010329_abnormal_lipoprotein_level1.93000123
24MP0009840_abnormal_foam_cell1.88613042
25MP0004272_abnormal_basement_membrane1.82324981
26MP0009384_cardiac_valve_regurgitation1.80915178
27MP0003279_aneurysm1.70569427
28MP0002896_abnormal_bone_mineralization1.63064862
29MP0001944_abnormal_pancreas_morphology1.56353605
30MP0002837_dystrophic_cardiac_calcinosis1.55438925
31MP0005257_abnormal_intraocular_pressure1.53462425
32MP0003300_gastrointestinal_ulcer1.53128072
33MP0003566_abnormal_cell_adhesion1.51961079
34MP0002060_abnormal_skin_morphology1.45167927
35MP0005332_abnormal_amino_acid1.44500244
36MP0000609_abnormal_liver_physiology1.38108381
37MP0003868_abnormal_feces_composition1.36281828
38MP0002693_abnormal_pancreas_physiology1.33307001
39MP0002138_abnormal_hepatobiliary_system1.32062568
40MP0002118_abnormal_lipid_homeostasis1.30806455
41MP0000003_abnormal_adipose_tissue1.29803170
42MP0009643_abnormal_urine_homeostasis1.29251057
43MP0004264_abnormal_extraembryonic_tissu1.27465657
44MP0010368_abnormal_lymphatic_system1.24633104
45MP0005023_abnormal_wound_healing1.22610683
46MP0002078_abnormal_glucose_homeostasis1.16686171
47MP0002295_abnormal_pulmonary_circulatio1.16329497
48MP0005164_abnormal_response_to1.15915121
49MP0001958_emphysema1.14268603
50MP0005084_abnormal_gallbladder_morpholo1.13514497
51MP0004134_abnormal_chest_morphology1.13019350
52MP0003448_altered_tumor_morphology1.12531971
53MP0004043_abnormal_pH_regulation1.11811964
54MP0005319_abnormal_enzyme/_coenzyme1.09995522
55MP0005508_abnormal_skeleton_morphology1.08170736
56MP0000462_abnormal_digestive_system1.07392032
57MP0001849_ear_inflammation1.05946545
58MP0002909_abnormal_adrenal_gland1.05777353
59MP0010352_gastrointestinal_tract_polyps1.05208356
60MP0002928_abnormal_bile_duct1.02994091
61MP0001243_abnormal_dermal_layer1.01011055
62MP0001879_abnormal_lymphatic_vessel1.00775935
63MP0010234_abnormal_vibrissa_follicle1.00237327
64MP0001915_intracranial_hemorrhage0.97335500
65MP0001542_abnormal_bone_strength0.96779325
66MP0003183_abnormal_peptide_metabolism0.96153060
67MP0009250_abnormal_appendicular_skeleto0.95269498
68MP0005595_abnormal_vascular_smooth0.94376633
69MP0005058_abnormal_lysosome_morphology0.94357903
70MP0000163_abnormal_cartilage_morphology0.91409146
71MP0001299_abnormal_eye_distance/0.90672671
72MP0004019_abnormal_vitamin_homeostasis0.89917508
73MP0001533_abnormal_skeleton_physiology0.88055843
74MP0000678_abnormal_parathyroid_gland0.87023237
75MP0002168_other_aberrant_phenotype0.86758114
76MP0005375_adipose_tissue_phenotype0.86677073
77MP0009053_abnormal_anal_canal0.86449037
78MP0003191_abnormal_cellular_cholesterol0.85853461
79MP0001348_abnormal_lacrimal_gland0.84482046
80MP0000598_abnormal_liver_morphology0.84416176
81MP0001756_abnormal_urination0.84256902
82MP0000534_abnormal_ureter_morphology0.83909314
83MP0003795_abnormal_bone_structure0.83335469
84MP0002933_joint_inflammation0.82548457
85MP0005408_hypopigmentation0.81731765
86MP0005390_skeleton_phenotype0.81141007
87MP0005379_endocrine/exocrine_gland_phen0.80664866
88MP0010386_abnormal_urinary_bladder0.80583144
89MP0001614_abnormal_blood_vessel0.79740302
90MP0002108_abnormal_muscle_morphology0.78521382
91MP0003959_abnormal_lean_body0.78037551
92MP0002115_abnormal_skeleton_extremities0.77964206
93MP0005076_abnormal_cell_differentiation0.77679850
94MP0002128_abnormal_blood_circulation0.77677067
95MP0005165_increased_susceptibility_to0.77665189
96MP0005451_abnormal_body_composition0.76169046
97MP0003828_pulmonary_edema0.74447480
98MP0008004_abnormal_stomach_pH0.69671545
99MP0000767_abnormal_smooth_muscle0.69638916
100MP0005409_darkened_coat_color0.69027009
101MP0005197_abnormal_uvea_morphology0.68882566
102MP0004185_abnormal_adipocyte_glucose0.68702067
103MP0000613_abnormal_salivary_gland0.68680253
104MP0004233_abnormal_muscle_weight0.67250972
105MP0003091_abnormal_cell_migration0.67044290
106MP0000733_abnormal_muscle_development0.67024157
107MP0005448_abnormal_energy_balance0.65651896
108MP0005636_abnormal_mineral_homeostasis0.65618476
109MP0005621_abnormal_cell_physiology0.65336416
110MP0004858_abnormal_nervous_system0.64644391
111MP0002925_abnormal_cardiovascular_devel0.64508048
112MP0002254_reproductive_system_inflammat0.64222247
113MP0002998_abnormal_bone_remodeling0.64188045
114MP0005670_abnormal_white_adipose0.64170110
115MP0003172_abnormal_lysosome_physiology0.64086566
116MP0003436_decreased_susceptibility_to0.63948660
117MP0003045_fibrosis0.63929078
118MP0001175_abnormal_lung_morphology0.63771431
119MP0000538_abnormal_urinary_bladder0.63327807
120MP0006082_CNS_inflammation0.63040038
121MP0000428_abnormal_craniofacial_morphol0.62969559
122MP0005666_abnormal_adipose_tissue0.62478026
123MP0005334_abnormal_fat_pad0.62223986
124MP0005623_abnormal_meninges_morphology0.62075059
125MP0000432_abnormal_head_morphology0.61654232
126MP0001661_extended_life_span0.61640646
127MP0000858_altered_metastatic_potential0.60551351
128MP0009697_abnormal_copulation0.60381044
129MP0009642_abnormal_blood_homeostasis0.59522354
130MP0004883_abnormal_blood_vessel0.59410168
131MP0004130_abnormal_muscle_cell0.59005345
132MP0001765_abnormal_ion_homeostasis0.57540211
133MP0004782_abnormal_surfactant_physiolog0.57316967
134MP0010307_abnormal_tumor_latency0.57078921
135MP0000249_abnormal_blood_vessel0.56555019
136MP0002133_abnormal_respiratory_system0.55366742
137MP0005388_respiratory_system_phenotype0.55366742
138MP0002113_abnormal_skeleton_development0.55351316
139MP0003942_abnormal_urinary_system0.55239920
140MP0000343_altered_response_to0.55171160
141MP0002971_abnormal_brown_adipose0.53572460
142MP0001881_abnormal_mammary_gland0.53381363
143MP0003385_abnormal_body_wall0.50813110

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.04918260
2Protrusio acetabuli (HP:0003179)4.85812865
3Premature rupture of membranes (HP:0001788)4.58597108
4Hypoglycemic seizures (HP:0002173)4.41590181
5Hyperinsulinemic hypoglycemia (HP:0000825)4.28916989
6Vascular tortuosity (HP:0004948)4.25643878
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.07506003
8Follicular hyperkeratosis (HP:0007502)4.06501940
9Abnormality of the intrinsic pathway (HP:0010989)3.99079990
10Arterial tortuosity (HP:0005116)3.94723354
11Intrahepatic cholestasis (HP:0001406)3.93727835
12Deep venous thrombosis (HP:0002625)3.88415821
13Xanthomatosis (HP:0000991)3.86228227
14Abnormality of the common coagulation pathway (HP:0010990)3.75824711
15Spondylolisthesis (HP:0003302)3.71236914
16Symptomatic seizures (HP:0011145)3.54300685
17Genu recurvatum (HP:0002816)3.52280145
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.44509356
19Hyperglycemia (HP:0003074)3.38735878
20Ketoacidosis (HP:0001993)3.34091189
21Hypobetalipoproteinemia (HP:0003563)3.14439527
22Complement deficiency (HP:0004431)3.06991513
23Prolonged partial thromboplastin time (HP:0003645)3.03512372
24Ketosis (HP:0001946)3.02428315
25Peritonitis (HP:0002586)3.01989017
26Cervical subluxation (HP:0003308)2.99723937
27Skin nodule (HP:0200036)2.85834466
28Osteolytic defects of the hand bones (HP:0009699)2.84725252
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.84725252
30Type 1 muscle fiber predominance (HP:0003803)2.81600888
31Abnormality of endocrine pancreas physiology (HP:0012093)2.76775908
32Abnormality of the pancreatic islet cells (HP:0006476)2.76775908
33Late onset (HP:0003584)2.73652253
34Hyperextensible skin (HP:0000974)2.71428174
35Atrophic scars (HP:0001075)2.71409519
36Slender build (HP:0001533)2.71062377
37Aortic dissection (HP:0002647)2.69948201
38Bowel diverticulosis (HP:0005222)2.69858858
39Overgrowth (HP:0001548)2.68639984
40Fat malabsorption (HP:0002630)2.67813883
41Joint laxity (HP:0001388)2.64012220
42Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63407100
43Conjugated hyperbilirubinemia (HP:0002908)2.62992074
44Hypolipoproteinemia (HP:0010981)2.59925387
45Ankle contracture (HP:0006466)2.57074210
46Cerebral aneurysm (HP:0004944)2.53472887
47Insulin-resistant diabetes mellitus (HP:0000831)2.51617696
48Protuberant abdomen (HP:0001538)2.48912748
49Mucopolysacchariduria (HP:0008155)2.48474450
50Urinary glycosaminoglycan excretion (HP:0003541)2.48474450
51Epidermoid cyst (HP:0200040)2.41952018
52Abnormality of complement system (HP:0005339)2.41442923
53Hypoalphalipoproteinemia (HP:0003233)2.40153849
54Thoracolumbar scoliosis (HP:0002944)2.37610462
55Pancreatic islet-cell hyperplasia (HP:0004510)2.37519562
56Myocardial infarction (HP:0001658)2.36244418
57Soft skin (HP:0000977)2.34926242
58Vertebral compression fractures (HP:0002953)2.34654197
59Hyperlipoproteinemia (HP:0010980)2.34392255
60Blue sclerae (HP:0000592)2.33913078
61Elbow flexion contracture (HP:0002987)2.32910625
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.30730136
63Biconcave vertebral bodies (HP:0004586)2.30096292
64Cupped ribs (HP:0000887)2.28786508
65Nonimmune hydrops fetalis (HP:0001790)2.28184547
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.26469486
67Aortic regurgitation (HP:0001659)2.25599939
68Aneurysm (HP:0002617)2.23072931
69Beaking of vertebral bodies (HP:0004568)2.22442373
70Aortic aneurysm (HP:0004942)2.21783149
71Insulin resistance (HP:0000855)2.20977035
72Abnormality of polysaccharide metabolism (HP:0011012)2.20406414
73Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20406414
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20406414
75Ovoid vertebral bodies (HP:0003300)2.19820495
76Mitral stenosis (HP:0001718)2.18664647
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.18422248
78Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.17187231
79Right ventricular cardiomyopathy (HP:0011663)2.16960758
80Abnormality of proline metabolism (HP:0010907)2.16252596
81Hydroxyprolinuria (HP:0003080)2.16252596
82Abdominal distention (HP:0003270)2.15544222
83Generalized aminoaciduria (HP:0002909)2.14545394
84Wormian bones (HP:0002645)2.13411769
85Ectopia lentis (HP:0001083)2.13053466
86Disproportionate tall stature (HP:0001519)2.12940554
87Abnormal tarsal ossification (HP:0008369)2.12273723
88Mitral valve prolapse (HP:0001634)2.11201843
89Abnormal foot bone ossification (HP:0010675)2.10956187
90Aortic valve stenosis (HP:0001650)2.10742820
91Fragile skin (HP:0001030)2.09013354
92Broad metatarsal (HP:0001783)2.07086584
93Joint hemorrhage (HP:0005261)2.06984664
94Abnormal cartilage morphology (HP:0002763)2.06204908
95Dilatation of the ascending aorta (HP:0005111)2.05458576
96Delayed closure of the anterior fontanelle (HP:0001476)2.04242209
97Mild short stature (HP:0003502)2.03741238
98Dysostosis multiplex (HP:0000943)2.03498918
99Abnormality of the ischium (HP:0003174)2.02648133
100Wide anterior fontanel (HP:0000260)2.01486482
101Syringomyelia (HP:0003396)2.00877573
102Spinal cord lesions (HP:0100561)2.00877573
103Bladder diverticulum (HP:0000015)2.00616617
104Abnormality of dentin (HP:0010299)2.00606329
105Hyperammonemia (HP:0001987)1.99443743
106Hypoplastic ischia (HP:0003175)1.98827097
107Abnormality of purine metabolism (HP:0004352)1.98088315
108Osteoarthritis (HP:0002758)1.96701277
109Vascular calcification (HP:0004934)1.95599479
110Back pain (HP:0003418)1.95582590
111Increased connective tissue (HP:0009025)1.95507129
112Mitral regurgitation (HP:0001653)1.95476755
113Increased variability in muscle fiber diameter (HP:0003557)1.94994355
114Short nail (HP:0001799)1.94650482
115Shallow orbits (HP:0000586)1.93621365
116Joint stiffness (HP:0001387)1.93464926
117Abnormal delivery (HP:0001787)1.93367797
118Hepatocellular carcinoma (HP:0001402)1.92905174
119Broad ribs (HP:0000885)1.92879918
120Mildly elevated creatine phosphokinase (HP:0008180)1.92773679
121Platyspondyly (HP:0000926)1.91660829
122Cardiovascular calcification (HP:0011915)1.91097799
123Thin bony cortex (HP:0002753)1.90971357
124Inguinal hernia (HP:0000023)1.90821092
125Natal tooth (HP:0000695)1.90672233
126Neonatal short-limb short stature (HP:0008921)1.89830597
127Abnormality of fatty-acid metabolism (HP:0004359)1.88788789
128Hypoventilation (HP:0002791)1.88096045
129Spinal rigidity (HP:0003306)1.88059925
130Persistence of primary teeth (HP:0006335)1.87801736
131Wrist flexion contracture (HP:0001239)1.87657785
132Long toe (HP:0010511)1.87272370
133Abnormality of the acetabulum (HP:0003170)1.85077028
134Breech presentation (HP:0001623)1.84830943
135Mesomelia (HP:0003027)1.84535421
136Abnormal enzyme/coenzyme activity (HP:0012379)1.84236664
137Abnormality of skull ossification (HP:0002703)1.83720289
138Coxa vara (HP:0002812)1.83065001
139Tetraparesis (HP:0002273)1.82128261
140Camptodactyly of toe (HP:0001836)1.81489225
141Absent frontal sinuses (HP:0002688)1.80454486
142Femoral bowing (HP:0002980)1.79071285
143Chondrocalcinosis (HP:0000934)1.75059518
144Abnormality of carpal bone ossification (HP:0006257)1.74908040
145Protruding ear (HP:0000411)1.74056961
146Relative macrocephaly (HP:0004482)1.71608318
147Round ear (HP:0100830)1.71065110
148Renal duplication (HP:0000075)1.70105543
149Osteopenia (HP:0000938)1.69777370
150Flat cornea (HP:0007720)1.69019047
151Asymmetry of the thorax (HP:0001555)1.68335586
152Pectus carinatum (HP:0000768)1.68116678
153Ulnar bowing (HP:0003031)1.67924750
154Abnormality of Sharpey fibers (HP:0100685)1.67351676
155Abnormality of skeletal muscle fiber size (HP:0012084)1.65968078
156Striae distensae (HP:0001065)1.65416425
157Delayed cranial suture closure (HP:0000270)1.64410814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.18761649
2INSRR3.68512081
3TRIB33.47716109
4FRK3.18041303
5SIK12.84571136
6LATS12.70756925
7BCKDK2.65162501
8TAOK32.63752758
9MAPK152.52466450
10FLT32.51828636
11PDGFRA2.48328031
12PASK2.21442219
13DDR22.21172752
14PKN22.18580216
15EPHA32.09908639
16PTK62.04035592
17FGFR41.95512968
18CDK121.94810899
19TTN1.90253978
20MET1.72446988
21PIK3CG1.72365500
22PTK21.64223954
23MAP3K31.61152524
24RIPK11.54534636
25MAP3K21.38855781
26STK381.28485243
27EPHB11.26776302
28MST1R1.25453279
29SCYL21.22098313
30ACVR1B1.21236057
31FER1.19965937
32TIE11.18861058
33PAK31.16635952
34LIMK11.13562039
35HIPK21.12538059
36NEK91.11083073
37KIT1.08643499
38NTRK11.07646667
39PTK2B1.07048516
40MAP3K141.06609361
41PAK21.05433843
42PRKD31.03588488
43MAP3K101.01206006
44ERBB40.99427255
45EPHA20.99185445
46CAMK1G0.97545595
47MELK0.97112403
48WNK10.96956425
49JAK10.94469655
50STK38L0.91610254
51NUAK10.89745241
52MTOR0.87201900
53STK30.85910179
54JAK30.84466443
55CLK10.83060542
56LATS20.81546597
57DYRK1B0.81508656
58MAP2K20.79443444
59BRSK20.78678344
60MAP3K10.77780269
61IRAK30.76361579
62TESK10.74216665
63PIK3CA0.73129392
64MAPK70.72669100
65PDGFRB0.72455364
66STK240.72389639
67PRPF4B0.71631228
68KSR20.70668294
69CSK0.68029212
70ICK0.67962333
71PRKG20.67347162
72MAPKAPK30.67308962
73TYK20.65129507
74JAK20.64381081
75FGFR30.63956180
76ROCK20.62152725
77TRPM70.61905853
78CDC42BPA0.61426890
79MAP2K10.61295026
80TGFBR20.60857869
81KDR0.60556219
82PRKCH0.59961106
83EEF2K0.59370057
84MYLK0.57912709
85CAMK1D0.57683339
86BMX0.56985821
87RET0.56556016
88PRKD20.56281980
89WNK40.55149484
90LRRK20.55143772
91GRK70.54096911
92GSK3A0.54095765
93PRKD10.54007943
94RPS6KA40.53254044
95TBK10.52879510
96STK100.52784842
97MAP3K120.51685767
98MAP3K80.50746635
99MAPK110.50583863
100SMG10.50325098
101IRAK10.49240965
102AKT30.48543076
103TEC0.47669894
104TGFBR10.44721208
105DAPK30.44583266
106DMPK0.44549620
107MAP2K30.44381110
108IGF1R0.44338283
109PRKAA20.43978425
110MAP3K130.43946445
111ABL20.43314478
112EPHB20.41646304
113PRKAA10.40605572
114TAOK20.39694196
115ADRBK10.38808626
116PRKCE0.37961056
117CDK60.37535942
118SGK30.37401797
119NEK10.37104191
120EIF2AK30.36693383
121MAP3K60.35844558
122ZAP700.35589211
123FGFR10.35229860
124CHUK0.34339621
125NLK0.32923877
126INSR0.31500193
127ERBB20.30704301
128PRKCI0.28510324
129ROCK10.27670175
130RPS6KA20.26813360
131MOS0.25415153
132PAK40.24905362
133PRKACG0.23650585

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.46769427
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.02080747
3Protein export_Homo sapiens_hsa030602.67855127
4Sulfur metabolism_Homo sapiens_hsa009202.66762048
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.57915549
6Tryptophan metabolism_Homo sapiens_hsa003802.54843951
7Nitrogen metabolism_Homo sapiens_hsa009102.47281377
8* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.31900323
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18685392
10Fatty acid degradation_Homo sapiens_hsa000712.17945796
11Complement and coagulation cascades_Homo sapiens_hsa046102.14526970
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.11503862
13Arginine biosynthesis_Homo sapiens_hsa002202.01709525
14Fat digestion and absorption_Homo sapiens_hsa049751.97765140
15Selenocompound metabolism_Homo sapiens_hsa004501.96930951
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.88427053
17Starch and sucrose metabolism_Homo sapiens_hsa005001.79267254
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69315814
19Folate biosynthesis_Homo sapiens_hsa007901.63717420
20Caffeine metabolism_Homo sapiens_hsa002321.63366840
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61795310
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58548368
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56219664
24Small cell lung cancer_Homo sapiens_hsa052221.52231940
25Butanoate metabolism_Homo sapiens_hsa006501.50485732
26PPAR signaling pathway_Homo sapiens_hsa033201.50456585
27Histidine metabolism_Homo sapiens_hsa003401.50356416
28Protein digestion and absorption_Homo sapiens_hsa049741.48907521
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47323807
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.40491259
31Fatty acid metabolism_Homo sapiens_hsa012121.39504272
32Peroxisome_Homo sapiens_hsa041461.37668423
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35919852
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32856533
35Phenylalanine metabolism_Homo sapiens_hsa003601.28068900
36TGF-beta signaling pathway_Homo sapiens_hsa043501.26628499
37Propanoate metabolism_Homo sapiens_hsa006401.25093618
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24516762
39ECM-receptor interaction_Homo sapiens_hsa045121.22283887
40Malaria_Homo sapiens_hsa051441.22025639
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.15893038
42Bile secretion_Homo sapiens_hsa049761.15669766
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13764423
44Staphylococcus aureus infection_Homo sapiens_hsa051501.13679404
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10798967
46Chemical carcinogenesis_Homo sapiens_hsa052041.10150533
47Galactose metabolism_Homo sapiens_hsa000521.09094730
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08583909
49ABC transporters_Homo sapiens_hsa020101.07947935
50TNF signaling pathway_Homo sapiens_hsa046681.05396272
51Thyroid cancer_Homo sapiens_hsa052161.05200381
52Sphingolipid metabolism_Homo sapiens_hsa006001.04832285
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04237131
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03877674
55beta-Alanine metabolism_Homo sapiens_hsa004101.03586227
56N-Glycan biosynthesis_Homo sapiens_hsa005101.03456456
57MicroRNAs in cancer_Homo sapiens_hsa052061.03411628
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.02314174
59Tyrosine metabolism_Homo sapiens_hsa003501.01509406
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00894314
61Lysine degradation_Homo sapiens_hsa003101.00882415
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00836307
63Chronic myeloid leukemia_Homo sapiens_hsa052200.98889746
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.96377896
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94918974
66Arginine and proline metabolism_Homo sapiens_hsa003300.91733224
67Shigellosis_Homo sapiens_hsa051310.91261285
68Vitamin digestion and absorption_Homo sapiens_hsa049770.91257824
69Insulin resistance_Homo sapiens_hsa049310.90752768
70Melanoma_Homo sapiens_hsa052180.89640023
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87132658
72Toxoplasmosis_Homo sapiens_hsa051450.86345082
73Dilated cardiomyopathy_Homo sapiens_hsa054140.86304517
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.86042266
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.84779626
76Pertussis_Homo sapiens_hsa051330.84445980
77Renin-angiotensin system_Homo sapiens_hsa046140.83406539
78Pyruvate metabolism_Homo sapiens_hsa006200.82058293
79Pancreatic cancer_Homo sapiens_hsa052120.80953135
80Pathways in cancer_Homo sapiens_hsa052000.78824674
81Hepatitis C_Homo sapiens_hsa051600.77314555
82Retinol metabolism_Homo sapiens_hsa008300.77297892
83Focal adhesion_Homo sapiens_hsa045100.75270665
84Prion diseases_Homo sapiens_hsa050200.75158530
85Carbon metabolism_Homo sapiens_hsa012000.72349124
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72014250
87Lysosome_Homo sapiens_hsa041420.71435554
88Hepatitis B_Homo sapiens_hsa051610.69854769
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69687617
90Renal cell carcinoma_Homo sapiens_hsa052110.67886136
91Platelet activation_Homo sapiens_hsa046110.64986245
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64945754
93Mineral absorption_Homo sapiens_hsa049780.64546837
94Amoebiasis_Homo sapiens_hsa051460.63603405
95Bladder cancer_Homo sapiens_hsa052190.63294822
96Measles_Homo sapiens_hsa051620.61956170
97Biosynthesis of amino acids_Homo sapiens_hsa012300.61285487
98Steroid biosynthesis_Homo sapiens_hsa001000.59716786
99Type II diabetes mellitus_Homo sapiens_hsa049300.59332023
100Influenza A_Homo sapiens_hsa051640.58660287
101Dorso-ventral axis formation_Homo sapiens_hsa043200.58374347
102Fatty acid elongation_Homo sapiens_hsa000620.57702472
103Prolactin signaling pathway_Homo sapiens_hsa049170.55775407
104Other glycan degradation_Homo sapiens_hsa005110.53887311
105Tight junction_Homo sapiens_hsa045300.52234199
106Thyroid hormone synthesis_Homo sapiens_hsa049180.52068981
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.51724650
108Phagosome_Homo sapiens_hsa041450.50426826
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50219299
110Vibrio cholerae infection_Homo sapiens_hsa051100.50060815
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49958885
112p53 signaling pathway_Homo sapiens_hsa041150.49914671
113One carbon pool by folate_Homo sapiens_hsa006700.49459725
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.49334829
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48052189
116Glycerolipid metabolism_Homo sapiens_hsa005610.47831037
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47116190
118Salmonella infection_Homo sapiens_hsa051320.46612186
119Hippo signaling pathway_Homo sapiens_hsa043900.46256982
120Endocytosis_Homo sapiens_hsa041440.46094009
121Glucagon signaling pathway_Homo sapiens_hsa049220.45514710
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.45387181
123African trypanosomiasis_Homo sapiens_hsa051430.44642951
124Rap1 signaling pathway_Homo sapiens_hsa040150.44348806
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42606932
126Insulin secretion_Homo sapiens_hsa049110.42423804
127Adherens junction_Homo sapiens_hsa045200.41667113
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.41545920
129Circadian rhythm_Homo sapiens_hsa047100.40788768
130Osteoclast differentiation_Homo sapiens_hsa043800.40646302
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.40478006
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.39954117
133Glutathione metabolism_Homo sapiens_hsa004800.39934787
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37628961
135Glioma_Homo sapiens_hsa052140.37611239
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37174467
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36205836
138AMPK signaling pathway_Homo sapiens_hsa041520.35500284
139Estrogen signaling pathway_Homo sapiens_hsa049150.35350873
140Fructose and mannose metabolism_Homo sapiens_hsa000510.35281591
141Proteoglycans in cancer_Homo sapiens_hsa052050.34413417
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34388784
143Apoptosis_Homo sapiens_hsa042100.34103397
144Leishmaniasis_Homo sapiens_hsa051400.33959738
145Acute myeloid leukemia_Homo sapiens_hsa052210.33474518
146Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33082925
147FoxO signaling pathway_Homo sapiens_hsa040680.32134786
148Pancreatic secretion_Homo sapiens_hsa049720.28443118
149Legionellosis_Homo sapiens_hsa051340.28147959
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.28028810
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26727065
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26332100
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25283656
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23419738
155Insulin signaling pathway_Homo sapiens_hsa049100.23305092
156Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22765943
157Prostate cancer_Homo sapiens_hsa052150.21562244
158Metabolic pathways_Homo sapiens_hsa011000.20844333

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