SEC31A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.83760564
2COPI coating of Golgi vesicle (GO:0048205)7.83760564
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.85015344
4protein retention in ER lumen (GO:0006621)5.37508260
5* activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.68952694
6* COPII vesicle coating (GO:0048208)4.57954962
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.50721426
8* positive regulation of nuclease activity (GO:0032075)4.49107365
9exocrine pancreas development (GO:0031017)4.10583822
10* regulation of nuclease activity (GO:0032069)4.07061350
11* endoplasmic reticulum unfolded protein response (GO:0030968)4.00554468
124-hydroxyproline metabolic process (GO:0019471)3.89064972
13intestinal cholesterol absorption (GO:0030299)3.85641512
14* cellular response to unfolded protein (GO:0034620)3.84779284
15sequestering of extracellular ligand from receptor (GO:0035581)3.80470400
16* ER-nucleus signaling pathway (GO:0006984)3.74189981
17cell adhesion mediated by integrin (GO:0033627)3.71316460
18* cellular response to topologically incorrect protein (GO:0035967)3.58722912
19nucleotide-sugar biosynthetic process (GO:0009226)3.57698496
20blood vessel maturation (GO:0001955)3.54496628
21intestinal absorption (GO:0050892)3.47889479
22* vesicle coating (GO:0006901)3.45377695
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.37851891
24collagen fibril organization (GO:0030199)3.30287616
25regulation of cholesterol homeostasis (GO:2000188)3.24147313
26cellular response to vitamin D (GO:0071305)3.22409957
27ER overload response (GO:0006983)3.21891433
28* response to endoplasmic reticulum stress (GO:0034976)3.18619944
29regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.14327601
30regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.14177746
31apoptotic cell clearance (GO:0043277)3.13793148
32skin morphogenesis (GO:0043589)3.12359277
33* ER to Golgi vesicle-mediated transport (GO:0006888)3.11750248
34positive regulation of fatty acid beta-oxidation (GO:0032000)3.09415666
35regulation of transforming growth factor beta2 production (GO:0032909)3.07956646
36positive regulation of protein autophosphorylation (GO:0031954)3.05374590
37* response to unfolded protein (GO:0006986)3.05187113
38regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.04769976
39L-alpha-amino acid transmembrane transport (GO:1902475)3.04650033
40peptidyl-proline hydroxylation (GO:0019511)3.03456335
41protein heterotrimerization (GO:0070208)3.03157640
42glomerular basement membrane development (GO:0032836)3.00602954
43UDP-N-acetylglucosamine metabolic process (GO:0006047)2.99956550
44insulin-like growth factor receptor signaling pathway (GO:0048009)2.99703971
45negative regulation of protein activation cascade (GO:2000258)2.98931307
46protein hydroxylation (GO:0018126)2.98431616
47regulation of fatty acid beta-oxidation (GO:0031998)2.95432848
48desmosome organization (GO:0002934)2.94095261
49substrate adhesion-dependent cell spreading (GO:0034446)2.92338334
50regulation of integrin-mediated signaling pathway (GO:2001044)2.90006967
51retina vasculature morphogenesis in camera-type eye (GO:0061299)2.89673172
52cellular response to vitamin (GO:0071295)2.89416061
53* response to topologically incorrect protein (GO:0035966)2.89275500
54regulation of metalloenzyme activity (GO:0048552)2.87840720
55folic acid-containing compound biosynthetic process (GO:0009396)2.86428413
56hormone catabolic process (GO:0042447)2.85761979
57endocardial cushion development (GO:0003197)2.84376626
58type B pancreatic cell development (GO:0003323)2.81484709
59sequestering of metal ion (GO:0051238)2.80206529
60lysine catabolic process (GO:0006554)2.79079321
61lysine metabolic process (GO:0006553)2.79079321
62negative regulation of complement activation (GO:0045916)2.77847935
63endodermal cell differentiation (GO:0035987)2.77254679
64negative regulation of fibrinolysis (GO:0051918)2.77030102
65protein maturation by protein folding (GO:0022417)2.76560628
66endocrine pancreas development (GO:0031018)2.76459408
67ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.75756803
68glandular epithelial cell development (GO:0002068)2.75393024
69epithelial cell-cell adhesion (GO:0090136)2.74884364
70intra-Golgi vesicle-mediated transport (GO:0006891)2.74037489
71negative regulation of fatty acid transport (GO:2000192)2.72437857
72regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.72223565
73positive regulation of hormone biosynthetic process (GO:0046886)2.71266479
74pericardium development (GO:0060039)2.71004886
75positive regulation of glycogen biosynthetic process (GO:0045725)2.70816311
76valine metabolic process (GO:0006573)2.70339075
77regulation of plasminogen activation (GO:0010755)2.69976326
78* protein N-linked glycosylation (GO:0006487)2.67696604
79zinc ion transport (GO:0006829)2.66813084
80peptidyl-glutamic acid carboxylation (GO:0017187)2.66146318
81protein carboxylation (GO:0018214)2.66146318
82columnar/cuboidal epithelial cell development (GO:0002066)2.65294809
83nucleotide-sugar metabolic process (GO:0009225)2.65186824
84intestinal epithelial cell development (GO:0060576)2.65075518
85negative regulation of cell size (GO:0045792)2.65052091
86tricarboxylic acid metabolic process (GO:0072350)2.63813322
87epoxygenase P450 pathway (GO:0019373)2.63029664
88lipid particle organization (GO:0034389)2.62999135
89positive regulation of histone deacetylation (GO:0031065)2.61380573
90Golgi organization (GO:0007030)2.59544449
91endocrine hormone secretion (GO:0060986)2.59094138
92alpha-linolenic acid metabolic process (GO:0036109)2.57551908
93mesenchymal-epithelial cell signaling (GO:0060638)2.57458574
94regulation of type B pancreatic cell apoptotic process (GO:2000674)2.56866016
95extracellular fibril organization (GO:0043206)2.56681549
96positive regulation of glycolytic process (GO:0045821)2.56634657
97proline biosynthetic process (GO:0006561)2.55862581
98sulfur amino acid catabolic process (GO:0000098)2.55260029
99smooth muscle tissue development (GO:0048745)2.55255746
100basement membrane organization (GO:0071711)2.55223611
101peptide hormone processing (GO:0016486)2.55021305
102dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.54387390
103fibroblast migration (GO:0010761)2.53559750
104glucocorticoid receptor signaling pathway (GO:0042921)2.53293342
105keratan sulfate catabolic process (GO:0042340)2.53246226
106homocysteine metabolic process (GO:0050667)2.53052042
107polarized epithelial cell differentiation (GO:0030859)2.52617249
108low-density lipoprotein particle clearance (GO:0034383)2.50788537
109cellular response to nutrient (GO:0031670)2.50640249
110type B pancreatic cell proliferation (GO:0044342)2.50292549
111maternal placenta development (GO:0001893)2.49823162
112negative regulation of endothelial cell apoptotic process (GO:2000352)2.49677036
113cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.49473205
114L-phenylalanine metabolic process (GO:0006558)2.49237379
115erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.49237379
116positive regulation of transforming growth factor beta production (GO:0071636)2.47239772
117chondrocyte proliferation (GO:0035988)2.46617286
118peptide catabolic process (GO:0043171)2.45095767
119vascular endothelial growth factor signaling pathway (GO:0038084)2.44007163
120negative regulation of chondrocyte differentiation (GO:0032331)2.43608739
121* peptidyl-asparagine modification (GO:0018196)2.43076881
122wound healing, spreading of epidermal cells (GO:0035313)2.41793426
123positive regulation of fatty acid oxidation (GO:0046321)2.40826960
124cell migration involved in sprouting angiogenesis (GO:0002042)2.40709632
125positive regulation of p38MAPK cascade (GO:1900745)2.40619410
126regulation of translational fidelity (GO:0006450)2.40562033
127* protein N-linked glycosylation via asparagine (GO:0018279)2.40331820
128lipoprotein metabolic process (GO:0042157)2.39886822
129midgut development (GO:0007494)2.39878547
130erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.39549123
131L-phenylalanine catabolic process (GO:0006559)2.39549123
132tonic smooth muscle contraction (GO:0014820)2.39484541
133regulation of transforming growth factor beta1 production (GO:0032908)2.37983810
134hippo signaling (GO:0035329)2.37650666
135lactate metabolic process (GO:0006089)2.37085463
136negative regulation of lipid transport (GO:0032369)2.34308890
137positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.32044472
138regulation of tight junction assembly (GO:2000810)2.30402654
139regulation of glucose import in response to insulin stimulus (GO:2001273)2.30374636
140protein autoprocessing (GO:0016540)2.30053622
141positive regulation of SMAD protein import into nucleus (GO:0060391)2.29950913
142regulation of cardioblast differentiation (GO:0051890)2.28356556
143positive regulation of cardiac muscle hypertrophy (GO:0010613)2.27301310
144positive regulation of muscle hypertrophy (GO:0014742)2.27301310
145positive regulation of hormone metabolic process (GO:0032352)2.27242427
146positive regulation of glycogen metabolic process (GO:0070875)2.27055557
147extracellular negative regulation of signal transduction (GO:1900116)2.26531625
148extracellular regulation of signal transduction (GO:1900115)2.26531625
149tooth mineralization (GO:0034505)2.26332875
150positive regulation of osteoblast proliferation (GO:0033690)2.25314535
151collagen metabolic process (GO:0032963)2.24460623
152regulation of transforming growth factor beta production (GO:0071634)2.23908593
153anterior/posterior axis specification, embryo (GO:0008595)2.23381562
154positive regulation of endothelial cell apoptotic process (GO:2000353)2.23145866
155glomerular visceral epithelial cell development (GO:0072015)2.23002365
156protein localization to Golgi apparatus (GO:0034067)2.22018847
157negative regulation of keratinocyte proliferation (GO:0010839)2.21198423
158negative regulation of axon extension involved in axon guidance (GO:0048843)2.21194834
159lung vasculature development (GO:0060426)2.19942258
160regulation of extracellular matrix disassembly (GO:0010715)2.19855187
161chondrocyte development (GO:0002063)2.18788929
162protein localization to cell surface (GO:0034394)2.18539506
163very-low-density lipoprotein particle assembly (GO:0034379)2.17375639
164embryonic cranial skeleton morphogenesis (GO:0048701)2.17190111
165multicellular organismal metabolic process (GO:0044236)2.16406765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.50325903
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.03227143
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.41466907
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.33136970
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.29840034
6CLOCK_20551151_ChIP-Seq_293T_Human3.22885169
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.22271700
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.07035830
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.98735772
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.90334501
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79313662
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.74462485
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65460646
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61980601
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57900325
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52756915
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44616547
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.42436628
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37198291
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32399431
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.30573705
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28933485
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.04399793
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00946641
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.98660780
26MYC_22102868_ChIP-Seq_BL_Human1.91428837
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.90699760
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.90699760
29ZNF274_21170338_ChIP-Seq_K562_Hela1.89072583
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87205197
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82196687
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.81473971
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80787720
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.78989990
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.78218984
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.77924894
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77426988
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.76624841
39ELK1_19687146_ChIP-ChIP_HELA_Human1.75864706
40ATF3_27146783_Chip-Seq_COLON_Human1.74369720
41TP53_18474530_ChIP-ChIP_U2OS_Human1.71702758
42GATA1_22025678_ChIP-Seq_K562_Human1.67050510
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63130019
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61335749
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59990759
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58348941
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.55822353
48RACK7_27058665_Chip-Seq_MCF-7_Human1.53527538
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.53119208
50GATA6_25053715_ChIP-Seq_YYC3_Human1.52006107
51CDX2_22108803_ChIP-Seq_LS180_Human1.51853321
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.51197985
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50689470
54GBX2_23144817_ChIP-Seq_PC3_Human1.49170597
55TP53_16413492_ChIP-PET_HCT116_Human1.48843173
56FUS_26573619_Chip-Seq_HEK293_Human1.47658082
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45202145
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44590820
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44587715
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44549436
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44019430
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.43910582
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43296703
64FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.42541243
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.42109506
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41043110
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39880030
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39614196
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36509961
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.35322335
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35244928
72* TBX20_22080862_ChIP-Seq_HEART_Mouse1.34932521
73* TBX20_22328084_ChIP-Seq_HEART_Mouse1.34932521
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34001707
75SMAD4_21799915_ChIP-Seq_A2780_Human1.33053557
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.32909791
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32198323
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32062303
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31505580
80BRD4_25478319_ChIP-Seq_HGPS_Human1.31419172
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29116053
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28199488
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28079120
84P300_19829295_ChIP-Seq_ESCs_Human1.28076276
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27567262
86CHD1_26751641_Chip-Seq_LNCaP_Human1.27253851
87ZNF263_19887448_ChIP-Seq_K562_Human1.26711705
88NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.26036603
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25396798
90* TCF7_22412390_ChIP-Seq_EML_Mouse1.25092744
91* FOXA2_19822575_ChIP-Seq_HepG2_Human1.25061601
92GATA4_25053715_ChIP-Seq_YYC3_Human1.25051044
93AR_21909140_ChIP-Seq_LNCAP_Human1.24493233
94* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24244808
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24023035
96LXR_22292898_ChIP-Seq_THP-1_Human1.23133659
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22388805
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21288905
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20123495
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18848486
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18504467
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.17923858
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16978939
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16348672
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16129766
106* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16033292
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15327407
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14432977
109FOXM1_23109430_ChIP-Seq_U2OS_Human1.13492656
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13454486
111STAT3_23295773_ChIP-Seq_U87_Human1.12551428
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12533656
113NCOR1_26117541_ChIP-Seq_K562_Human1.12350969
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11890009
115STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10463868
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08829332
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08619269
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08573354
119KDM2B_26808549_Chip-Seq_DND41_Human1.08125820
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.07322104
121RUNX1_27514584_Chip-Seq_MCF-7_Human1.07268345
122ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07243356
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07042310
124CREB1_26743006_Chip-Seq_LNCaP_Human1.05991692
125TFEB_21752829_ChIP-Seq_HELA_Human1.05827807
126EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05654251
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05568751
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05564548
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05455832
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05151406
131SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04936214
132SOX17_20123909_ChIP-Seq_XEN_Mouse1.04437567
133UBF1/2_26484160_Chip-Seq_HMECs_Human1.04235316
134* TP63_23658742_ChIP-Seq_EP156T_Human1.04231810
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04139876
136AHR_22903824_ChIP-Seq_MCF-7_Human1.03209823
137CMYC_18555785_Chip-Seq_ESCs_Mouse1.03128120
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03090479
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02392637
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02274012
141ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02256675
142SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02177539
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02177539
144TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01380801
145* E2F1_18555785_Chip-Seq_ESCs_Mouse1.01376088
146CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01186869
147GATA3_24758297_ChIP-Seq_MCF-7_Human1.01079690
148BCAT_22108803_ChIP-Seq_LS180_Human1.00768788
149NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99874013
150PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.99483632
151GABP_17652178_ChIP-ChIP_JURKAT_Human0.99438727
152ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99191926
153CRX_20693478_ChIP-Seq_RETINA_Mouse0.97719932
154EOMES_21245162_ChIP-Seq_HESCs_Human0.97577788
155GATA4_21415370_ChIP-Seq_HL-1_Mouse0.97468496
156EWS_26573619_Chip-Seq_HEK293_Human0.97265089
157ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95243690
158TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94123973
159ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93954596
160SOX2_20726797_ChIP-Seq_SW620_Human0.93376852
161TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92139268
162* HNF4A_19822575_ChIP-Seq_HepG2_Human0.92034138
163KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91461948
164* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90656848
165ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89959348
166CJUN_26792858_Chip-Seq_BT549_Human0.89809539
167MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.89254089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.09648743
2MP0003705_abnormal_hypodermis_morpholog3.72977118
3MP0003950_abnormal_plasma_membrane3.43678999
4MP0005275_abnormal_skin_tensile2.78884396
5MP0002877_abnormal_melanocyte_morpholog2.72406710
6MP0003283_abnormal_digestive_organ2.69278774
7MP0010352_gastrointestinal_tract_polyps2.46114415
8MP0002139_abnormal_hepatobiliary_system2.42976733
9MP0005503_abnormal_tendon_morphology2.41635197
10MP0003941_abnormal_skin_development2.35917433
11MP0005360_urolithiasis2.35002853
12MP0005365_abnormal_bile_salt2.34263622
13MP0003252_abnormal_bile_duct2.16914186
14MP0006054_spinal_hemorrhage2.13614689
15MP0003300_gastrointestinal_ulcer2.05045728
16MP0003566_abnormal_cell_adhesion2.02354186
17MP0004264_abnormal_extraembryonic_tissu1.86849872
18MP0005220_abnormal_exocrine_pancreas1.86223547
19MP0004272_abnormal_basement_membrane1.84645452
20MP0001666_abnormal_nutrient_absorption1.79853801
21MP0005085_abnormal_gallbladder_physiolo1.71131494
22MP0002896_abnormal_bone_mineralization1.70942062
23MP0009780_abnormal_chondrocyte_physiolo1.68683650
24MP0005076_abnormal_cell_differentiation1.67139041
25MP0003279_aneurysm1.67124337
26MP0000013_abnormal_adipose_tissue1.64748661
27MP0000516_abnormal_urinary_system1.63369068
28MP0005367_renal/urinary_system_phenotyp1.63369068
29MP0009384_cardiac_valve_regurgitation1.60542358
30MP0010234_abnormal_vibrissa_follicle1.54730895
31MP0005023_abnormal_wound_healing1.50316137
32MP0001944_abnormal_pancreas_morphology1.43530132
33MP0003195_calcinosis1.42264499
34MP0001661_extended_life_span1.41283756
35MP0000003_abnormal_adipose_tissue1.39232153
36MP0002060_abnormal_skin_morphology1.35584990
37MP0005257_abnormal_intraocular_pressure1.29537733
38MP0010030_abnormal_orbit_morphology1.25867069
39MP0000678_abnormal_parathyroid_gland1.25313429
40MP0005408_hypopigmentation1.24265765
41MP0005508_abnormal_skeleton_morphology1.22068211
42MP0004134_abnormal_chest_morphology1.21254910
43MP0002837_dystrophic_cardiac_calcinosis1.20447351
44MP0002876_abnormal_thyroid_physiology1.19610347
45MP0010368_abnormal_lymphatic_system1.19497605
46MP0009053_abnormal_anal_canal1.18156053
47MP0002938_white_spotting1.16940845
48MP0001542_abnormal_bone_strength1.15462235
49MP0010386_abnormal_urinary_bladder1.15125253
50MP0010329_abnormal_lipoprotein_level1.12758557
51MP0004185_abnormal_adipocyte_glucose1.11065772
52MP0002693_abnormal_pancreas_physiology1.09228051
53MP0001849_ear_inflammation1.09107363
54MP0001879_abnormal_lymphatic_vessel1.07514195
55MP0003806_abnormal_nucleotide_metabolis1.07381462
56MP0005171_absent_coat_pigmentation1.06990308
57MP0005375_adipose_tissue_phenotype1.03780092
58MP0009840_abnormal_foam_cell1.03343106
59MP0003937_abnormal_limbs/digits/tail_de1.02666593
60MP0000462_abnormal_digestive_system1.01658269
61MP0002909_abnormal_adrenal_gland1.01286407
62MP0005083_abnormal_biliary_tract1.00743533
63MP0002234_abnormal_pharynx_morphology0.99936455
64MP0000537_abnormal_urethra_morphology0.99447492
65MP0000163_abnormal_cartilage_morphology0.97244894
66MP0003123_paternal_imprinting0.97033103
67MP0009250_abnormal_appendicular_skeleto0.96428098
68MP0000538_abnormal_urinary_bladder0.95340049
69MP0001958_emphysema0.95079900
70MP0009643_abnormal_urine_homeostasis0.94686098
71MP0004197_abnormal_fetal_growth/weight/0.94527364
72MP0008961_abnormal_basal_metabolism0.94130151
73MP0000609_abnormal_liver_physiology0.94096658
74MP0000733_abnormal_muscle_development0.93803032
75MP0004084_abnormal_cardiac_muscle0.93108825
76MP0003868_abnormal_feces_composition0.91578669
77MP0003115_abnormal_respiratory_system0.90639199
78MP0000428_abnormal_craniofacial_morphol0.90363977
79MP0009697_abnormal_copulation0.90298694
80MP0001243_abnormal_dermal_layer0.90201638
81MP0009672_abnormal_birth_weight0.90042500
82MP0005666_abnormal_adipose_tissue0.89428445
83MP0002108_abnormal_muscle_morphology0.88258981
84MP0003045_fibrosis0.88111543
85MP0003119_abnormal_digestive_system0.87719780
86MP0002168_other_aberrant_phenotype0.87009496
87MP0002078_abnormal_glucose_homeostasis0.86586863
88MP0003091_abnormal_cell_migration0.86327246
89MP0004233_abnormal_muscle_weight0.86321328
90MP0003755_abnormal_palate_morphology0.86308202
91MP0001915_intracranial_hemorrhage0.85958110
92MP0001756_abnormal_urination0.85458132
93MP0002928_abnormal_bile_duct0.85209546
94MP0000639_abnormal_adrenal_gland0.85084657
95MP0005670_abnormal_white_adipose0.82966823
96MP0002115_abnormal_skeleton_extremities0.82591740
97MP0005623_abnormal_meninges_morphology0.81578882
98MP0002089_abnormal_postnatal_growth/wei0.81162157
99MP0002128_abnormal_blood_circulation0.80755279
100MP0005395_other_phenotype0.80539775
101MP0008875_abnormal_xenobiotic_pharmacok0.80210953
102MP0004043_abnormal_pH_regulation0.79895348
103MP0002086_abnormal_extraembryonic_tissu0.79551914
104MP0002282_abnormal_trachea_morphology0.78969470
105MP0002254_reproductive_system_inflammat0.78265842
106MP0005332_abnormal_amino_acid0.77965726
107MP0010630_abnormal_cardiac_muscle0.77719886
108MP0008775_abnormal_heart_ventricle0.77521017
109MP0002088_abnormal_embryonic_growth/wei0.77374544
110MP0000767_abnormal_smooth_muscle0.76387026
111MP0003984_embryonic_growth_retardation0.76220706
112MP0003935_abnormal_craniofacial_develop0.74978806
113MP0000598_abnormal_liver_morphology0.74606489
114MP0005319_abnormal_enzyme/_coenzyme0.73690915
115MP0002269_muscular_atrophy0.73288754
116MP0003942_abnormal_urinary_system0.72457214
117MP0003795_abnormal_bone_structure0.72100626
118MP0001614_abnormal_blood_vessel0.71331260
119MP0005187_abnormal_penis_morphology0.71265466
120MP0003385_abnormal_body_wall0.71212173
121MP0009703_decreased_birth_body0.70511408
122MP0003122_maternal_imprinting0.70501423
123MP0005164_abnormal_response_to0.70399753
124MP0002295_abnormal_pulmonary_circulatio0.69583348
125MP0004087_abnormal_muscle_fiber0.69251777
126MP0000613_abnormal_salivary_gland0.68963622
127MP0002118_abnormal_lipid_homeostasis0.68759007
128MP0001299_abnormal_eye_distance/0.68617615
129MP0003186_abnormal_redox_activity0.68599375
130MP0000432_abnormal_head_morphology0.68344962
131MP0000534_abnormal_ureter_morphology0.68330916
132MP0005248_abnormal_Harderian_gland0.67777235
133MP0002925_abnormal_cardiovascular_devel0.67757812
134MP0001270_distended_abdomen0.66980498
135MP0005197_abnormal_uvea_morphology0.64433206
136MP0002084_abnormal_developmental_patter0.63748440
137MP0002233_abnormal_nose_morphology0.62430913
138MP0002177_abnormal_outer_ear0.62307772
139MP0000762_abnormal_tongue_morphology0.61339719
140MP0008007_abnormal_cellular_replicative0.60555410
141MP0000749_muscle_degeneration0.54120422
142MP0000751_myopathy0.53673387

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.37649674
2Premature rupture of membranes (HP:0001788)4.27655574
3Vascular tortuosity (HP:0004948)4.19583892
4Follicular hyperkeratosis (HP:0007502)3.97853471
5Arterial tortuosity (HP:0005116)3.88872269
6Hypoglycemic coma (HP:0001325)3.87037695
7Cervical subluxation (HP:0003308)3.42324308
8Hyperinsulinemic hypoglycemia (HP:0000825)3.40827602
9Ankle contracture (HP:0006466)3.34562995
10Cerebral aneurysm (HP:0004944)3.32108390
11Hypoglycemic seizures (HP:0002173)3.25075862
12Cardiovascular calcification (HP:0011915)3.11368404
13Hyperglycemia (HP:0003074)2.93011312
14Aortic dissection (HP:0002647)2.89113508
15Shallow orbits (HP:0000586)2.87989162
16Atrophic scars (HP:0001075)2.87192208
17Abnormal delivery (HP:0001787)2.83165873
18Mitral stenosis (HP:0001718)2.80620949
19Aortic aneurysm (HP:0004942)2.78351425
20Abnormality of the intrinsic pathway (HP:0010989)2.74241362
21Hypobetalipoproteinemia (HP:0003563)2.73093966
22Aneurysm (HP:0002617)2.69358817
23Symptomatic seizures (HP:0011145)2.61880873
24Mitral valve prolapse (HP:0001634)2.59060890
25Broad metatarsal (HP:0001783)2.58098768
26Right ventricular cardiomyopathy (HP:0011663)2.56464010
27Mildly elevated creatine phosphokinase (HP:0008180)2.55614469
28Ketoacidosis (HP:0001993)2.53773210
29Peritonitis (HP:0002586)2.51731684
30Abnormality of the pancreatic islet cells (HP:0006476)2.49923214
31Abnormality of endocrine pancreas physiology (HP:0012093)2.49923214
32Bladder diverticulum (HP:0000015)2.44425368
33Vascular calcification (HP:0004934)2.44024013
34Dilatation of the ascending aorta (HP:0005111)2.43468444
35Genu recurvatum (HP:0002816)2.41687032
36Blue sclerae (HP:0000592)2.38218471
37Thin bony cortex (HP:0002753)2.35668038
38Increased connective tissue (HP:0009025)2.34358933
39Soft skin (HP:0000977)2.30755662
40Deep venous thrombosis (HP:0002625)2.29998819
41Fragile skin (HP:0001030)2.29578005
42Thoracolumbar scoliosis (HP:0002944)2.28832314
43Hypolipoproteinemia (HP:0010981)2.28218095
44Abnormality of the common coagulation pathway (HP:0010990)2.27905528
45Popliteal pterygium (HP:0009756)2.24114460
46Metaphyseal cupping (HP:0003021)2.24100771
47Flat acetabular roof (HP:0003180)2.22900424
48Pancreatic islet-cell hyperplasia (HP:0004510)2.20172005
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19290478
50Late onset (HP:0003584)2.19191875
51Type 1 muscle fiber predominance (HP:0003803)2.19169639
52Spinal rigidity (HP:0003306)2.18626085
53Abnormality of monocarboxylic acid metabolism (HP:0010996)2.17379493
54Abnormality of carpal bone ossification (HP:0006257)2.16908057
55Abnormality of the acetabulum (HP:0003170)2.16678826
56Insulin-resistant diabetes mellitus (HP:0000831)2.16595128
57Hypoplastic ischia (HP:0003175)2.16542967
58Biconcave vertebral bodies (HP:0004586)2.13759281
59Xanthomatosis (HP:0000991)2.13233155
60Asymmetry of the thorax (HP:0001555)2.12635052
61Hand muscle atrophy (HP:0009130)2.11118777
62Abnormality of glycolysis (HP:0004366)2.10896458
63Wormian bones (HP:0002645)2.09828660
64Delayed gross motor development (HP:0002194)2.08694462
65Long toe (HP:0010511)2.06300463
66Intrahepatic cholestasis (HP:0001406)2.06240318
67Entropion (HP:0000621)2.06102883
68Neonatal short-limb short stature (HP:0008921)2.04296873
69Subacute progressive viral hepatitis (HP:0006572)2.03385539
70Abnormality of the ischium (HP:0003174)2.03267785
71Striae distensae (HP:0001065)2.03227249
72Abnormal foot bone ossification (HP:0010675)2.02867773
73Cupped ribs (HP:0000887)2.02804401
74Lymphangioma (HP:0100764)2.02762945
75Insulin resistance (HP:0000855)2.02595814
76Skin nodule (HP:0200036)2.01943158
77Back pain (HP:0003418)2.01744764
78Ketosis (HP:0001946)1.98514745
79Bowel diverticulosis (HP:0005222)1.97859936
80Distal upper limb amyotrophy (HP:0007149)1.97279684
81Upper limb amyotrophy (HP:0009129)1.97279684
82Joint laxity (HP:0001388)1.96972014
83Abnormal protein glycosylation (HP:0012346)1.95816682
84Abnormal glycosylation (HP:0012345)1.95816682
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95816682
86Abnormal protein N-linked glycosylation (HP:0012347)1.95816682
87Abnormal cartilage morphology (HP:0002763)1.95078358
88Platyspondyly (HP:0000926)1.92440279
89Increased serum pyruvate (HP:0003542)1.91485710
90Hypothermia (HP:0002045)1.90070592
91Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89192060
92Exostoses (HP:0100777)1.88514123
93Hepatoblastoma (HP:0002884)1.88487767
94Inguinal hernia (HP:0000023)1.87666627
95Ectopia lentis (HP:0001083)1.86571068
96Breech presentation (HP:0001623)1.85959906
97Protuberant abdomen (HP:0001538)1.84637416
98Enlarged penis (HP:0000040)1.84336484
99Severe short stature (HP:0003510)1.82648314
100Fat malabsorption (HP:0002630)1.82491800
101Mucopolysacchariduria (HP:0008155)1.82462384
102Urinary glycosaminoglycan excretion (HP:0003541)1.82462384
103Abdominal distention (HP:0003270)1.81696012
104Ulnar bowing (HP:0003031)1.81581421
105Hyperextensible skin (HP:0000974)1.81218995
106Delayed closure of the anterior fontanelle (HP:0001476)1.81072642
107Nonimmune hydrops fetalis (HP:0001790)1.80961662
108Mild short stature (HP:0003502)1.80306398
109Abnormality of dentin (HP:0010299)1.78572057
110Beaking of vertebral bodies (HP:0004568)1.77592040
111Abnormality of the distal phalanges of the toes (HP:0010182)1.76877599
112Abnormal tarsal ossification (HP:0008369)1.76557316
113Orthostatic hypotension (HP:0001278)1.76488945
114Tibial bowing (HP:0002982)1.76480413
115Increased corneal curvature (HP:0100692)1.76305633
116Keratoconus (HP:0000563)1.76305633
117Redundant skin (HP:0001582)1.75902488
118Wide anterior fontanel (HP:0000260)1.75157785
119Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74632444
120Vertebral compression fractures (HP:0002953)1.74212148
121Metaphyseal dysplasia (HP:0100255)1.74144087
122Pectus carinatum (HP:0000768)1.73371001
123Type I transferrin isoform profile (HP:0003642)1.73358801
124Aortic regurgitation (HP:0001659)1.73012642
125Congenital glaucoma (HP:0001087)1.71392298
126Hypokinesia (HP:0002375)1.70967126
127Ovoid vertebral bodies (HP:0003300)1.70714726
128Abnormal hand bone ossification (HP:0010660)1.70470806
129Missing ribs (HP:0000921)1.70098970
130Aortic valve stenosis (HP:0001650)1.69851034
131Rectal prolapse (HP:0002035)1.69652561
132Hypoplasia of the odontoid process (HP:0003311)1.68721828
133Rhizomelia (HP:0008905)1.68505817
134Wrist flexion contracture (HP:0001239)1.67902861
135Proximal tubulopathy (HP:0000114)1.67887051
136Abnormality of proline metabolism (HP:0010907)1.67773409
137Hydroxyprolinuria (HP:0003080)1.67773409
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.67725710
139Osteolytic defects of the hand bones (HP:0009699)1.67725710
140Macroorchidism (HP:0000053)1.67099988
141Hypoalphalipoproteinemia (HP:0003233)1.66793917
142Mesomelia (HP:0003027)1.66678090
143Upper limb muscle weakness (HP:0003484)1.66575665
144Spondylolisthesis (HP:0003302)1.66289949
145Difficulty climbing stairs (HP:0003551)1.65625010
146Turricephaly (HP:0000262)1.64649403
147Osteoarthritis (HP:0002758)1.64618720
148Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.64466308
149Radial bowing (HP:0002986)1.64379742
150Disproportionate short-trunk short stature (HP:0003521)1.64370439
151Abnormal pancreas size (HP:0012094)1.63078634
152Flared iliac wings (HP:0002869)1.62508767
153Infantile muscular hypotonia (HP:0008947)1.62386954
154Overgrowth (HP:0001548)1.60926631
155Overlapping toe (HP:0001845)1.60015032
156Steatorrhea (HP:0002570)1.57945996
157Limited hip movement (HP:0008800)1.55309560
158Natal tooth (HP:0000695)1.54051323
159Pulmonic stenosis (HP:0001642)1.52808242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.07267054
2TRIB33.98922260
3PKN23.12535573
4LATS13.07717822
5EIF2AK32.95904965
6INSRR2.66306393
7PDGFRA2.65452989
8EIF2AK12.64327304
9SIK12.60704078
10PDK22.39641126
11FLT32.37008278
12FRK2.34408608
13CDK122.33210055
14TTN2.19971531
15PASK2.19659988
16BCR2.14722110
17DDR22.12704194
18PTK62.04589811
19EEF2K2.01924340
20TAOK32.00783680
21MAP3K101.95257341
22MST41.95041507
23RIPK11.92086743
24TRIM281.70240088
25MAP3K121.66521733
26BCKDK1.65677610
27FGFR21.63973128
28PTK21.63487703
29ERBB31.57044613
30SCYL21.52923058
31PLK21.48951080
32MTOR1.41829392
33EPHA21.41210826
34PRKD31.41008892
35FGFR41.40571239
36EPHA31.35304173
37LIMK11.32637765
38MET1.23668818
39FER1.23329387
40ERBB41.23164065
41PAK21.20619873
42MAP3K31.13168051
43STK31.12944571
44CAMK1D1.12274427
45TIE11.10401660
46LATS21.10317624
47MAP4K21.03477332
48BMPR1B1.03362247
49PBK1.00475217
50STK38L1.00473606
51NLK0.99222664
52PRKCE0.98479623
53PLK30.98298750
54ACVR1B0.97998840
55LRRK20.93521423
56PAK40.90909459
57STK390.90609403
58RPS6KA40.87701475
59TESK10.87340064
60HIPK20.86424637
61PIK3CG0.86275699
62ROCK10.85309184
63CDC42BPA0.84169778
64TSSK60.83414651
65MAPK150.82692761
66MAP3K20.81271801
67GRK10.81242599
68FGFR10.80512148
69DYRK1B0.80060449
70TGFBR20.79698538
71STK380.79232701
72PDGFRB0.78767743
73CLK10.78692200
74MAPKAPK30.77403072
75DMPK0.75959115
76BMX0.75573605
77CDK60.74937151
78PAK30.74105777
79FGFR30.74067156
80PTK2B0.73158466
81WNK40.72608458
82CAMK1G0.70892915
83STK100.70208728
84ICK0.69731783
85BRSK20.69290192
86CSNK1G10.69074851
87BRD40.68792524
88LMTK20.67525767
89MAP2K30.67436530
90NEK90.65287910
91AKT30.64841755
92MAP2K10.64710155
93CSNK1A1L0.64269996
94NEK10.64163573
95PRKG20.63834402
96PNCK0.61978584
97JAK10.61944025
98WNK30.61702835
99CDK80.59985801
100PRKAA20.59517915
101TGFBR10.59513068
102MAP3K80.58959512
103MUSK0.58796578
104RET0.58399446
105RPS6KB20.57788818
106SRPK10.57037797
107PIM20.56564514
108TAOK10.56546697
109ROCK20.55742492
110MAPKAPK50.54369221
111JAK30.54330884
112EPHB10.53223767
113SIK30.50368505
114ALK0.50182926
115EPHB20.49935956
116WNK10.49632389
117MAP3K10.49357876
118ZAP700.48596102
119NUAK10.46851895
120ADRBK10.46595464
121MAPK110.45658695
122CDK40.45099278
123CASK0.45042622
124PRKCH0.44851878
125NEK20.44389652
126TNIK0.43499074
127MELK0.43000055
128KDR0.42918208
129PRKAA10.42477019
130NTRK10.41407436
131PDK30.40966472
132PDK40.40966472
133PIK3CA0.40844223
134MAP2K20.40395626
135PRKD10.38902264
136GSK3A0.37850622
137JAK20.37580204
138TRPM70.36555022
139CHUK0.36439513
140MYLK0.35162837
141TTK0.35087774
142ILK0.34905889
143ERBB20.34646379
144PRKD20.34641019
145MAP3K70.34370922
146MST1R0.34276984
147CSNK1G30.33379117
148ABL10.32646988

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.42790216
2* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.66953118
3Selenocompound metabolism_Homo sapiens_hsa004502.46629494
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22534682
5Sulfur metabolism_Homo sapiens_hsa009202.08671602
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06857884
7Steroid biosynthesis_Homo sapiens_hsa001002.05081715
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.97327237
9Fat digestion and absorption_Homo sapiens_hsa049751.97176893
10Protein digestion and absorption_Homo sapiens_hsa049741.95794440
11Tryptophan metabolism_Homo sapiens_hsa003801.93912888
12Nitrogen metabolism_Homo sapiens_hsa009101.93063869
13Fatty acid degradation_Homo sapiens_hsa000711.82642216
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76949853
15Lysine degradation_Homo sapiens_hsa003101.74135743
16Fatty acid elongation_Homo sapiens_hsa000621.73298943
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69761209
18ECM-receptor interaction_Homo sapiens_hsa045121.68857691
19Protein export_Homo sapiens_hsa030601.66681178
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58169836
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57942964
22Starch and sucrose metabolism_Homo sapiens_hsa005001.56360249
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.53860731
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51162454
25Adherens junction_Homo sapiens_hsa045201.50767601
26Insulin resistance_Homo sapiens_hsa049311.40583866
27Arginine biosynthesis_Homo sapiens_hsa002201.39361857
28Focal adhesion_Homo sapiens_hsa045101.37368313
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34612152
30Bladder cancer_Homo sapiens_hsa052191.34452407
31Galactose metabolism_Homo sapiens_hsa000521.34242179
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33091997
33Vibrio cholerae infection_Homo sapiens_hsa051101.27420627
34Folate biosynthesis_Homo sapiens_hsa007901.27039719
35One carbon pool by folate_Homo sapiens_hsa006701.24737049
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20289251
37N-Glycan biosynthesis_Homo sapiens_hsa005101.19241305
38PPAR signaling pathway_Homo sapiens_hsa033201.15784655
39Sphingolipid metabolism_Homo sapiens_hsa006001.15663916
40Caffeine metabolism_Homo sapiens_hsa002321.15216727
41Fatty acid metabolism_Homo sapiens_hsa012121.12590473
42Circadian rhythm_Homo sapiens_hsa047101.11654526
43Vitamin B6 metabolism_Homo sapiens_hsa007501.11323003
44Glutathione metabolism_Homo sapiens_hsa004801.10731803
45Complement and coagulation cascades_Homo sapiens_hsa046101.07205761
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03787307
47Renin-angiotensin system_Homo sapiens_hsa046141.03632803
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01413178
49Propanoate metabolism_Homo sapiens_hsa006401.00518938
50Proteoglycans in cancer_Homo sapiens_hsa052051.00058853
51Carbon metabolism_Homo sapiens_hsa012000.99283914
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97909968
53Bile secretion_Homo sapiens_hsa049760.96598702
54Thyroid cancer_Homo sapiens_hsa052160.96119788
55Biosynthesis of amino acids_Homo sapiens_hsa012300.94397987
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92672336
57Other glycan degradation_Homo sapiens_hsa005110.92383076
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91223579
59Type II diabetes mellitus_Homo sapiens_hsa049300.90272919
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.89506629
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89337060
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.88758213
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88487039
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87413449
65Chronic myeloid leukemia_Homo sapiens_hsa052200.87328952
66Glucagon signaling pathway_Homo sapiens_hsa049220.87106006
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86921695
68Small cell lung cancer_Homo sapiens_hsa052220.86852876
69mTOR signaling pathway_Homo sapiens_hsa041500.84678035
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.83798991
71Pyruvate metabolism_Homo sapiens_hsa006200.82805797
72Amoebiasis_Homo sapiens_hsa051460.81801467
73ABC transporters_Homo sapiens_hsa020100.81713532
74AMPK signaling pathway_Homo sapiens_hsa041520.80247695
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80173255
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79924304
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.79122561
78Butanoate metabolism_Homo sapiens_hsa006500.78662487
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78641490
80Retinol metabolism_Homo sapiens_hsa008300.75082139
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.72974935
82Insulin signaling pathway_Homo sapiens_hsa049100.70110983
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69375722
84Mineral absorption_Homo sapiens_hsa049780.69026205
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68348770
86Thyroid hormone synthesis_Homo sapiens_hsa049180.67736908
87Prostate cancer_Homo sapiens_hsa052150.67711317
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67534031
89TGF-beta signaling pathway_Homo sapiens_hsa043500.67285106
90Hippo signaling pathway_Homo sapiens_hsa043900.66496397
91MicroRNAs in cancer_Homo sapiens_hsa052060.66434316
92Chemical carcinogenesis_Homo sapiens_hsa052040.65901603
93Non-homologous end-joining_Homo sapiens_hsa034500.65724194
94Phenylalanine metabolism_Homo sapiens_hsa003600.65064698
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64692906
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.64307097
97Endometrial cancer_Homo sapiens_hsa052130.64302625
98Vitamin digestion and absorption_Homo sapiens_hsa049770.62448133
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62149608
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60455050
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59892467
102Basal transcription factors_Homo sapiens_hsa030220.59450657
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56228236
104Fructose and mannose metabolism_Homo sapiens_hsa000510.56118458
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55850819
106p53 signaling pathway_Homo sapiens_hsa041150.55510942
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53727620
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53589387
109Dilated cardiomyopathy_Homo sapiens_hsa054140.53080935
110Arginine and proline metabolism_Homo sapiens_hsa003300.52458580
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51453626
112Histidine metabolism_Homo sapiens_hsa003400.51176117
113Insulin secretion_Homo sapiens_hsa049110.49824390
114Peroxisome_Homo sapiens_hsa041460.49815998
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49562449
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48473038
117Basal cell carcinoma_Homo sapiens_hsa052170.48435929
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48074530
119Proteasome_Homo sapiens_hsa030500.48071007
120Metabolic pathways_Homo sapiens_hsa011000.46130070
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44842352
122beta-Alanine metabolism_Homo sapiens_hsa004100.44747667
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44174415
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44168442
125Hedgehog signaling pathway_Homo sapiens_hsa043400.43691146
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.43521145
127Tight junction_Homo sapiens_hsa045300.43391269
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43271840
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43046889
130Prolactin signaling pathway_Homo sapiens_hsa049170.42862449
131Glycerolipid metabolism_Homo sapiens_hsa005610.42583667
132Pancreatic cancer_Homo sapiens_hsa052120.41012612
133Antigen processing and presentation_Homo sapiens_hsa046120.38733779
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.37785749

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