SEC61A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glutamate secretion (GO:0014047)6.11384548
2negative regulation of synaptic transmission, glutamatergic (GO:0051967)6.05566627
3ionotropic glutamate receptor signaling pathway (GO:0035235)5.75394941
4pyrimidine nucleobase catabolic process (GO:0006208)5.74236814
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.53085508
6regulation of respiratory gaseous exchange by neurological system process (GO:0002087)5.50342201
7response to pheromone (GO:0019236)5.47269122
8synaptic transmission, glutamatergic (GO:0035249)5.31913237
9glutamate receptor signaling pathway (GO:0007215)4.81770934
10daunorubicin metabolic process (GO:0044597)4.80195125
11polyketide metabolic process (GO:0030638)4.80195125
12doxorubicin metabolic process (GO:0044598)4.80195125
13regulation of respiratory system process (GO:0044065)4.76486918
14neuron recognition (GO:0008038)4.73857566
15neuron-neuron synaptic transmission (GO:0007270)4.60177774
16nucleobase catabolic process (GO:0046113)4.48386472
17regulation of DNA methylation (GO:0044030)4.41753609
18neuron cell-cell adhesion (GO:0007158)4.39674433
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.29285178
20establishment of mitochondrion localization (GO:0051654)4.17690894
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.12653401
22retinal ganglion cell axon guidance (GO:0031290)4.10396229
23DNA methylation involved in gamete generation (GO:0043046)4.08960656
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.05361060
25suckling behavior (GO:0001967)4.03553270
26regulation of respiratory gaseous exchange (GO:0043576)3.99072348
27neuronal action potential propagation (GO:0019227)3.96513811
28synaptic vesicle maturation (GO:0016188)3.93169534
29behavioral fear response (GO:0001662)3.87836639
30behavioral defense response (GO:0002209)3.87836639
31vocalization behavior (GO:0071625)3.87240047
32protein localization to synapse (GO:0035418)3.86360116
33regulation of synaptic vesicle exocytosis (GO:2000300)3.86317696
34synaptic vesicle exocytosis (GO:0016079)3.83865359
35neurotransmitter-gated ion channel clustering (GO:0072578)3.80112965
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.76525837
37regulation of feeding behavior (GO:0060259)3.71599608
38neurotransmitter secretion (GO:0007269)3.71343133
39nonmotile primary cilium assembly (GO:0035058)3.68592492
40regulation of synapse structural plasticity (GO:0051823)3.68301203
41cardiac left ventricle morphogenesis (GO:0003214)3.68261908
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.61697054
43presynaptic membrane assembly (GO:0097105)3.61508291
44positive regulation of catecholamine secretion (GO:0033605)3.52532704
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.50394378
46fear response (GO:0042596)3.50120965
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.48834629
48regulation of synaptic vesicle transport (GO:1902803)3.47113827
49regulation of gene expression by genetic imprinting (GO:0006349)3.46619227
50membrane depolarization during action potential (GO:0086010)3.46450890
51regulation of glutamate receptor signaling pathway (GO:1900449)3.46010931
52regulation of synapse assembly (GO:0051963)3.44320882
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.41024104
54establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.40972657
55mitochondrion transport along microtubule (GO:0047497)3.40972657
56postsynaptic membrane organization (GO:0001941)3.39219399
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.38195042
58locomotory exploration behavior (GO:0035641)3.35979131
59regulation of neuronal synaptic plasticity (GO:0048168)3.34136727
60cerebellar granule cell differentiation (GO:0021707)3.32357186
61presynaptic membrane organization (GO:0097090)3.32172619
62axonal fasciculation (GO:0007413)3.27863308
63transmission of nerve impulse (GO:0019226)3.27364338
64regulation of postsynaptic membrane potential (GO:0060078)3.25082949
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24226784
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21747235
67regulation of synapse organization (GO:0050807)3.21205878
68dendritic spine morphogenesis (GO:0060997)3.18181521
69neurotransmitter transport (GO:0006836)3.15028774
70cell migration in hindbrain (GO:0021535)3.14958626
71negative regulation of membrane potential (GO:0045837)3.14759524
72cerebellar Purkinje cell differentiation (GO:0021702)3.14044482
73calcium ion import (GO:0070509)3.10337917
74regulation of dopamine secretion (GO:0014059)3.09974041
75behavioral response to nicotine (GO:0035095)3.07756423
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06997139
77DNA double-strand break processing (GO:0000729)3.06072687
78genetic imprinting (GO:0071514)3.05241384
79dicarboxylic acid biosynthetic process (GO:0043650)3.05045794
80membrane depolarization (GO:0051899)3.02311408
81gamma-aminobutyric acid transport (GO:0015812)3.02238580
82axon extension (GO:0048675)3.01930294
83intraciliary transport (GO:0042073)2.97216724
84synapse assembly (GO:0007416)2.96827672
85synaptic vesicle endocytosis (GO:0048488)2.96718504
86protein localization to cilium (GO:0061512)2.94837431
87exploration behavior (GO:0035640)2.94759827
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91359895
89regulation of neurotransmitter levels (GO:0001505)2.90981499
90regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.90725561
91neurofilament cytoskeleton organization (GO:0060052)2.89681825
92regulation of neurotransmitter secretion (GO:0046928)2.88553347
93forebrain neuron development (GO:0021884)2.87265586
94regulation of vesicle fusion (GO:0031338)2.86993573
95cerebral cortex radially oriented cell migration (GO:0021799)2.85975609
96positive regulation of synapse assembly (GO:0051965)2.85539890
97calcium ion-dependent exocytosis (GO:0017156)2.84408896
98startle response (GO:0001964)2.81909765
99aminoglycoside antibiotic metabolic process (GO:0030647)2.81848969
100proline transport (GO:0015824)2.81230376
101positive regulation of mitochondrial fission (GO:0090141)2.81149630
102regulation of synapse maturation (GO:0090128)2.81084998
103positive regulation of synapse maturation (GO:0090129)2.79615612
104central nervous system projection neuron axonogenesis (GO:0021952)2.79109931
105adult walking behavior (GO:0007628)2.79089195
106long-term synaptic potentiation (GO:0060291)2.78456031
107positive regulation of neurotransmitter secretion (GO:0001956)2.78375947
108forebrain neuron differentiation (GO:0021879)2.78236515
109DNA damage response, detection of DNA damage (GO:0042769)2.76232722
110neuronal ion channel clustering (GO:0045161)2.73219482
111synaptic transmission (GO:0007268)2.71737345
112regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.71103939
113regulation of circadian sleep/wake cycle (GO:0042749)2.71103939
114hippocampus development (GO:0021766)2.69679110
115auditory behavior (GO:0031223)2.69462740
116regulation of synaptic plasticity (GO:0048167)2.69288695
117negative regulation of synaptic transmission (GO:0050805)2.67966193
118regulation of synaptic transmission, GABAergic (GO:0032228)2.67574485
119regulation of sensory perception of pain (GO:0051930)2.67423591
120regulation of sensory perception (GO:0051931)2.67423591
121innervation (GO:0060384)2.67197687
122ubiquinone metabolic process (GO:0006743)2.66836701
123synapse organization (GO:0050808)2.66687435
124mechanosensory behavior (GO:0007638)2.64964686
125regulation of dendritic spine morphogenesis (GO:0061001)2.64281320
126neuromuscular synaptic transmission (GO:0007274)2.63410661
127glycosphingolipid biosynthetic process (GO:0006688)2.62815178
128dendrite morphogenesis (GO:0048813)2.61710423
129positive regulation of dendritic spine morphogenesis (GO:0061003)2.61076692
130acrosome reaction (GO:0007340)2.58183519
131positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.57066704
132cytoskeleton-dependent intracellular transport (GO:0030705)2.54062024
133retinal cone cell development (GO:0046549)2.50179601
134microtubule-based transport (GO:0010970)2.47363676
135histone H2A acetylation (GO:0043968)2.47143509
136layer formation in cerebral cortex (GO:0021819)2.46392500
137central nervous system neuron axonogenesis (GO:0021955)2.44426316
138regulation of cilium movement (GO:0003352)2.41653835
139C4-dicarboxylate transport (GO:0015740)2.39788409
140anterograde axon cargo transport (GO:0008089)2.36934481
141inner ear receptor stereocilium organization (GO:0060122)2.36024628
142axon cargo transport (GO:0008088)2.35464247
143negative regulation of DNA recombination (GO:0045910)2.35363436
144mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.33286085
145positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.33286085
146neuron fate determination (GO:0048664)2.32790945
147establishment of protein localization to mitochondrial membrane (GO:0090151)2.31782888
148cilium morphogenesis (GO:0060271)2.31699541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.23272175
2GBX2_23144817_ChIP-Seq_PC3_Human4.92561321
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.60966501
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.56374153
5TAF15_26573619_Chip-Seq_HEK293_Human2.77939482
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60633428
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55952710
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.51701033
9FUS_26573619_Chip-Seq_HEK293_Human2.40574181
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38874564
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33120496
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31498951
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31184145
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27065643
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.22717555
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.20270876
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.10780620
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08684242
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07909007
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04807238
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04807238
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02335455
23REST_21632747_ChIP-Seq_MESCs_Mouse2.01946585
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00799309
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00472238
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98271599
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92802260
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91254016
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87040626
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86790329
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.84183031
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.83364324
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78955588
34SMAD4_21799915_ChIP-Seq_A2780_Human1.78676647
35DROSHA_22980978_ChIP-Seq_HELA_Human1.78407938
36P300_19829295_ChIP-Seq_ESCs_Human1.74514112
37ZNF274_21170338_ChIP-Seq_K562_Hela1.73907363
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.73324065
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71946272
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.70735581
41VDR_22108803_ChIP-Seq_LS180_Human1.68822550
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.66637084
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.66468526
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65931900
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65881589
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.60911402
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60230785
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58548755
49EWS_26573619_Chip-Seq_HEK293_Human1.57684976
50FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.56798326
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55976608
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55860429
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55308909
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.54017240
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48047730
56RNF2_27304074_Chip-Seq_NSC_Mouse1.43523792
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.43395239
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42164901
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40620931
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40289815
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39326673
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36487201
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36487201
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36025818
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35730795
66IGF1R_20145208_ChIP-Seq_DFB_Human1.35296633
67STAT3_23295773_ChIP-Seq_U87_Human1.34130567
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.34008368
69CBP_20019798_ChIP-Seq_JUKART_Human1.33351339
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33351339
71LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33332562
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32486799
73* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30102703
74IRF1_19129219_ChIP-ChIP_H3396_Human1.28929851
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.28064838
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26025752
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25541337
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.23822805
79AR_25329375_ChIP-Seq_VCAP_Human1.23585198
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23317143
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.20727322
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20661056
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19886024
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19886024
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19886024
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19758649
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.18504518
88* TCF4_23295773_ChIP-Seq_U87_Human1.18205819
89* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17422862
90* JUN_21703547_ChIP-Seq_K562_Human1.14956956
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14750345
92ER_23166858_ChIP-Seq_MCF-7_Human1.14302159
93* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13893314
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13821809
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.13532481
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.10789806
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10481007
98TP53_22573176_ChIP-Seq_HFKS_Human1.09702784
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09371403
100BCAT_22108803_ChIP-Seq_LS180_Human1.08279069
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08211358
102P53_22387025_ChIP-Seq_ESCs_Mouse1.08035699
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.06028713
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05829674
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05427899
106SOX2_16153702_ChIP-ChIP_HESCs_Human1.05396936
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04830528
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03083108
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02633936
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02344307
111SOX9_26525672_Chip-Seq_HEART_Mouse1.02176886
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.01946357
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00952156
114WT1_19549856_ChIP-ChIP_CCG9911_Human0.99451377
115* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99059367
116MYC_18940864_ChIP-ChIP_HL60_Human0.98575742
117ELK1_19687146_ChIP-ChIP_HELA_Human0.98301389
118RUNX2_22187159_ChIP-Seq_PCA_Human0.97351441
119AR_19668381_ChIP-Seq_PC3_Human0.96003177
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95956676
121NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94779688
122IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94013320
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.93853907
124SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93498739
125AR_21572438_ChIP-Seq_LNCaP_Human0.93078776
126TAL1_26923725_Chip-Seq_HPCs_Mouse0.92486589
127* PRDM14_20953172_ChIP-Seq_ESCs_Human0.89916990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.56606117
2MP0003880_abnormal_central_pattern4.57660352
3MP0008877_abnormal_DNA_methylation4.56469613
4MP0002736_abnormal_nociception_after3.75193345
5MP0002735_abnormal_chemical_nociception3.47725438
6MP0001968_abnormal_touch/_nociception3.31909825
7MP0003635_abnormal_synaptic_transmissio2.98999606
8MP0009745_abnormal_behavioral_response2.61342399
9MP0002063_abnormal_learning/memory/cond2.60608730
10MP0002064_seizures2.57296481
11MP0005367_renal/urinary_system_phenotyp2.53749053
12MP0000516_abnormal_urinary_system2.53749053
13MP0001501_abnormal_sleep_pattern2.53358277
14MP0002572_abnormal_emotion/affect_behav2.47213479
15MP0002272_abnormal_nervous_system2.41192451
16MP0004270_analgesia2.32072457
17MP0005670_abnormal_white_adipose2.25719098
18MP0001440_abnormal_grooming_behavior2.16265960
19MP0009046_muscle_twitch2.11781564
20MP0000955_abnormal_spinal_cord2.01460140
21MP0002067_abnormal_sensory_capabilities1.98839640
22MP0001486_abnormal_startle_reflex1.89430402
23MP0001188_hyperpigmentation1.80377912
24MP0002734_abnormal_mechanical_nocicepti1.80270095
25MP0000778_abnormal_nervous_system1.71728864
26MP0006276_abnormal_autonomic_nervous1.69368909
27MP0002184_abnormal_innervation1.68182845
28MP0003122_maternal_imprinting1.65185033
29MP0008789_abnormal_olfactory_epithelium1.63895140
30MP0003123_paternal_imprinting1.53065559
31MP0001970_abnormal_pain_threshold1.51959914
32MP0002557_abnormal_social/conspecific_i1.51119297
33MP0005409_darkened_coat_color1.49517342
34MP0002653_abnormal_ependyma_morphology1.49086140
35MP0005171_absent_coat_pigmentation1.46552913
36MP0003787_abnormal_imprinting1.45002744
37MP0004924_abnormal_behavior1.43555045
38MP0005386_behavior/neurological_phenoty1.43555045
39MP0006292_abnormal_olfactory_placode1.43043646
40MP0005423_abnormal_somatic_nervous1.40711523
41MP0001529_abnormal_vocalization1.39062878
42MP0002882_abnormal_neuron_morphology1.38364581
43MP0000749_muscle_degeneration1.35394895
44MP0008058_abnormal_DNA_repair1.33963996
45MP0002733_abnormal_thermal_nociception1.31079156
46MP0004885_abnormal_endolymph1.30428209
47MP0003136_yellow_coat_color1.28835963
48MP0004811_abnormal_neuron_physiology1.27102081
49MP0005646_abnormal_pituitary_gland1.25936923
50MP0001984_abnormal_olfaction1.24115696
51MP0005645_abnormal_hypothalamus_physiol1.22842054
52MP0004145_abnormal_muscle_electrophysio1.22076931
53MP0000569_abnormal_digit_pigmentation1.18977973
54MP0000013_abnormal_adipose_tissue1.18123584
55MP0003121_genomic_imprinting1.17094337
56MP0002066_abnormal_motor_capabilities/c1.16660255
57MP0001299_abnormal_eye_distance/1.14898084
58MP0000534_abnormal_ureter_morphology1.14795090
59MP0008569_lethality_at_weaning1.12598577
60MP0002822_catalepsy1.12278832
61MP0004142_abnormal_muscle_tone1.11561011
62MP0002938_white_spotting1.08459596
63MP0005187_abnormal_penis_morphology1.07835980
64MP0001293_anophthalmia1.06273307
65MP0000631_abnormal_neuroendocrine_gland1.05245461
66MP0001905_abnormal_dopamine_level1.04805733
67MP0009379_abnormal_foot_pigmentation1.03449261
68MP0002752_abnormal_somatic_nervous1.03256323
69MP0003937_abnormal_limbs/digits/tail_de1.02354482
70MP0004858_abnormal_nervous_system1.02244979
71MP0002152_abnormal_brain_morphology1.00197416
72MP0005248_abnormal_Harderian_gland0.97401224
73MP0001502_abnormal_circadian_rhythm0.97270328
74MP0003890_abnormal_embryonic-extraembry0.94348656
75MP0003634_abnormal_glial_cell0.93407220
76MP0000747_muscle_weakness0.93299514
77MP0005551_abnormal_eye_electrophysiolog0.93025232
78MP0001963_abnormal_hearing_physiology0.92283555
79MP0001986_abnormal_taste_sensitivity0.91604355
80MP0003119_abnormal_digestive_system0.88333156
81MP0000566_synostosis0.88001535
82MP0003861_abnormal_nervous_system0.86233673
83MP0003698_abnormal_male_reproductive0.85623409
84MP0004742_abnormal_vestibular_system0.83894574
85MP0001485_abnormal_pinna_reflex0.81504377
86MP0003879_abnormal_hair_cell0.81058549
87MP0002234_abnormal_pharynx_morphology0.80962887
88MP0008995_early_reproductive_senescence0.79269323
89MP0000647_abnormal_sebaceous_gland0.79002562
90MP0002210_abnormal_sex_determination0.78401420
91MP0003755_abnormal_palate_morphology0.78325823
92MP0004085_abnormal_heartbeat0.77488923
93MP0005623_abnormal_meninges_morphology0.77398050
94MP0003938_abnormal_ear_development0.76566995
95MP0002229_neurodegeneration0.76438318
96MP0002751_abnormal_autonomic_nervous0.75633020
97MP0001286_abnormal_eye_development0.73789182
98MP0002102_abnormal_ear_morphology0.73586983
99MP0005195_abnormal_posterior_eye0.73564826
100MP0002069_abnormal_eating/drinking_beha0.73137315
101MP0006072_abnormal_retinal_apoptosis0.72787022
102MP0000026_abnormal_inner_ear0.72426008
103MP0000751_myopathy0.72065607
104MP0005253_abnormal_eye_physiology0.71841420
105MP0002909_abnormal_adrenal_gland0.71239521
106MP0002081_perinatal_lethality0.70086573
107MP0001929_abnormal_gametogenesis0.69890810
108MP0009780_abnormal_chondrocyte_physiolo0.69050180
109MP0002638_abnormal_pupillary_reflex0.68726898
110MP0003567_abnormal_fetal_cardiomyocyte0.68654556
111MP0003329_amyloid_beta_deposits0.68037328
112MP0003631_nervous_system_phenotype0.65991389
113MP0002928_abnormal_bile_duct0.65932510
114MP0004133_heterotaxia0.65924451
115MP0002082_postnatal_lethality0.64885247
116MP0010770_preweaning_lethality0.64885247
117MP0003633_abnormal_nervous_system0.64190162
118MP0006035_abnormal_mitochondrial_morpho0.63433045
119MP0003632_abnormal_nervous_system0.63059042
120MP0000049_abnormal_middle_ear0.61776515
121MP0001177_atelectasis0.61219017
122MP0005394_taste/olfaction_phenotype0.60420856
123MP0005499_abnormal_olfactory_system0.60420856
124MP0010769_abnormal_survival0.60287890
125MP0000003_abnormal_adipose_tissue0.60264850
126MP0002233_abnormal_nose_morphology0.60071172
127MP0003942_abnormal_urinary_system0.58702241

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.54710765
2Calf muscle hypertrophy (HP:0008981)5.11884154
3Muscle hypertrophy of the lower extremities (HP:0008968)4.76170098
4Type II lissencephaly (HP:0007260)4.74147091
5Epileptic encephalopathy (HP:0200134)4.72283174
6Shoulder girdle muscle weakness (HP:0003547)4.69244899
7Hypoventilation (HP:0002791)4.66784634
8Cerebellar dysplasia (HP:0007033)4.62445005
9Pelvic girdle muscle weakness (HP:0003749)4.25801216
10Abnormality of the musculature of the pelvis (HP:0001469)4.07043862
11Abnormality of the hip-girdle musculature (HP:0001445)4.07043862
12Febrile seizures (HP:0002373)3.98909826
13Hypoplasia of the pons (HP:0012110)3.86033252
14Abnormality of the pons (HP:0007361)3.78048512
15Focal seizures (HP:0007359)3.43490170
16Limb-girdle muscle atrophy (HP:0003797)3.36905110
17Myokymia (HP:0002411)3.33832651
18Atonic seizures (HP:0010819)3.17701309
19Cortical dysplasia (HP:0002539)3.00690523
20Poor eye contact (HP:0000817)2.90762922
21Visual hallucinations (HP:0002367)2.81086912
22Polyphagia (HP:0002591)2.75512382
23Nonprogressive disorder (HP:0003680)2.75135584
24Achilles tendon contracture (HP:0001771)2.74117490
25Follicular hyperkeratosis (HP:0007502)2.74042448
26Broad-based gait (HP:0002136)2.72972010
27Abnormality of the calf musculature (HP:0001430)2.71352999
28Septo-optic dysplasia (HP:0100842)2.69127280
29True hermaphroditism (HP:0010459)2.68960309
30Progressive cerebellar ataxia (HP:0002073)2.65664162
31Centrally nucleated skeletal muscle fibers (HP:0003687)2.64948287
32Colon cancer (HP:0003003)2.60110923
33Hyperventilation (HP:0002883)2.59273235
34Aplasia/Hypoplasia of the brainstem (HP:0007362)2.57303653
35Hypoplasia of the brainstem (HP:0002365)2.57303653
36Specific learning disability (HP:0001328)2.54529103
37Generalized tonic-clonic seizures (HP:0002069)2.50835706
38Amblyopia (HP:0000646)2.49786944
39Pancreatic fibrosis (HP:0100732)2.49224142
40Abnormality of midbrain morphology (HP:0002418)2.47824704
41Molar tooth sign on MRI (HP:0002419)2.47824704
42Optic nerve hypoplasia (HP:0000609)2.45587544
43Action tremor (HP:0002345)2.43853934
44Pancreatic cysts (HP:0001737)2.42242761
45Frequent falls (HP:0002359)2.40253289
46Renal hypoplasia (HP:0000089)2.39560573
47Retinal dysplasia (HP:0007973)2.38841582
48Lissencephaly (HP:0001339)2.35391820
49Delayed gross motor development (HP:0002194)2.34968178
50Oligodactyly (HP:0012165)2.33960265
51Increased variability in muscle fiber diameter (HP:0003557)2.33530378
52Absence seizures (HP:0002121)2.30518527
53Abnormality of the Achilles tendon (HP:0005109)2.27321857
54Protruding tongue (HP:0010808)2.27288290
55Abnormal social behavior (HP:0012433)2.25857099
56Impaired social interactions (HP:0000735)2.25857099
57Failure to thrive in infancy (HP:0001531)2.25010948
58Difficulty climbing stairs (HP:0003551)2.24101106
59Severe visual impairment (HP:0001141)2.20903487
60Facial hemangioma (HP:0000329)2.20660466
61Dialeptic seizures (HP:0011146)2.19284953
62Oligodactyly (hands) (HP:0001180)2.16669778
63Poor head control (HP:0002421)2.16587796
64Absent speech (HP:0001344)2.16130538
65Excessive salivation (HP:0003781)2.15712020
66Drooling (HP:0002307)2.15712020
67Gaze-evoked nystagmus (HP:0000640)2.15605375
68Medial flaring of the eyebrow (HP:0010747)2.15366420
69Poor coordination (HP:0002370)2.12965825
70Gait imbalance (HP:0002141)2.11670067
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09993185
72Hyperglycinemia (HP:0002154)2.08884054
73Epileptiform EEG discharges (HP:0011182)2.08536041
74Intestinal atresia (HP:0011100)2.04535031
75Meningocele (HP:0002435)2.01982320
76Spastic gait (HP:0002064)2.01708837
77Impaired vibration sensation in the lower limbs (HP:0002166)2.00926010
78Broad distal phalanx of finger (HP:0009836)2.00839434
79Limb-girdle muscle weakness (HP:0003325)2.00629007
80Macroglossia (HP:0000158)2.00438551
81Astrocytoma (HP:0009592)2.00210140
82Abnormality of the astrocytes (HP:0100707)2.00210140
83Cystic liver disease (HP:0006706)1.99435042
84Supranuclear gaze palsy (HP:0000605)1.98753031
85Abnormal eating behavior (HP:0100738)1.96693853
86Postaxial hand polydactyly (HP:0001162)1.95875984
87Methylmalonic acidemia (HP:0002912)1.95747117
88EEG with generalized epileptiform discharges (HP:0011198)1.95502527
89Pachygyria (HP:0001302)1.94746297
90Abnormality of skeletal muscle fiber size (HP:0012084)1.93783276
91Rib fusion (HP:0000902)1.91358353
92Ependymoma (HP:0002888)1.91338726
93Muscular dystrophy (HP:0003560)1.90826757
94Aqueductal stenosis (HP:0002410)1.88991485
95Labial hypoplasia (HP:0000066)1.88929321
96Split foot (HP:0001839)1.88005945
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.87884790
98Weak cry (HP:0001612)1.87581480
99Fetal akinesia sequence (HP:0001989)1.86833354
100Status epilepticus (HP:0002133)1.86582360
101Nephronophthisis (HP:0000090)1.85709272
102Spastic tetraplegia (HP:0002510)1.85456412
103Severe muscular hypotonia (HP:0006829)1.85051697
104Hypsarrhythmia (HP:0002521)1.84977093
105Medulloblastoma (HP:0002885)1.84934566
106Intellectual disability, profound (HP:0002187)1.83840076
107Proximal amyotrophy (HP:0007126)1.83282524
108Hepatoblastoma (HP:0002884)1.83256185
109Congenital primary aphakia (HP:0007707)1.82431101
110Broad foot (HP:0001769)1.82183975
111Absent septum pellucidum (HP:0001331)1.81987636
112Hypoplastic female external genitalia (HP:0012815)1.81628513
113Gastroesophageal reflux (HP:0002020)1.80441961
114Abnormality of the renal medulla (HP:0100957)1.79939094
115Narrow forehead (HP:0000341)1.79870478
116Genital tract atresia (HP:0001827)1.78873968
117Vaginal atresia (HP:0000148)1.78665607
118Blue irides (HP:0000635)1.78232838
119Urinary urgency (HP:0000012)1.77287903
120Cerebral hypomyelination (HP:0006808)1.76247581
121Generalized muscle weakness (HP:0003324)1.74175731
122Anencephaly (HP:0002323)1.74026965
123Occipital encephalocele (HP:0002085)1.73934900
124Amyotrophic lateral sclerosis (HP:0007354)1.73763474
125Degeneration of the lateral corticospinal tracts (HP:0002314)1.71527919
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71527919
127Abnormality of the labia minora (HP:0012880)1.71527693
128Chronic hepatic failure (HP:0100626)1.70566124
129Growth hormone deficiency (HP:0000824)1.70522008
130Dyskinesia (HP:0100660)1.70423330
131Postaxial foot polydactyly (HP:0001830)1.70192591
132Inability to walk (HP:0002540)1.69319798
133Neonatal respiratory distress (HP:0002643)1.68655521
134Nephrogenic diabetes insipidus (HP:0009806)1.68112850
135Round face (HP:0000311)1.67334652
136Acute necrotizing encephalopathy (HP:0006965)1.66789588
137Abnormality of the lower motor neuron (HP:0002366)1.66454504
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.65843091
139Sleep apnea (HP:0010535)1.65091535
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64943062
141Preaxial hand polydactyly (HP:0001177)1.64325146
142Abnormal hair whorl (HP:0010721)1.63894422
143Micropenis (HP:0000054)1.63404497
144EMG: myopathic abnormalities (HP:0003458)1.62750769
145Progressive inability to walk (HP:0002505)1.61791965
146Esotropia (HP:0000565)1.61408926
147Ankle clonus (HP:0011448)1.60873983
148Sclerocornea (HP:0000647)1.60405259
149Widely spaced teeth (HP:0000687)1.59596250
150Postural instability (HP:0002172)1.58098550
151Hypothermia (HP:0002045)1.57879793
152Left ventricular hypertrophy (HP:0001712)1.57287910
153Myoglobinuria (HP:0002913)1.55739015
154Diplopia (HP:0000651)1.55645734
155Abnormality of binocular vision (HP:0011514)1.55645734
156Truncal ataxia (HP:0002078)1.55428159
157Abnormality of the corticospinal tract (HP:0002492)1.54168019
158Abnormality of the shoulder girdle musculature (HP:0001435)1.53900502
159Hemiparesis (HP:0001269)1.52610211
160Dysmetria (HP:0001310)1.52592305
161Limb dystonia (HP:0002451)1.51069367
162Anophthalmia (HP:0000528)1.49963650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.73351650
2NTRK34.06109043
3EPHA43.86970506
4CASK3.31117602
5TRIM283.16922066
6MAP3K43.05238744
7MAP2K72.76724358
8MAP4K22.72077985
9PLK22.64529233
10MARK12.56404796
11TNIK2.56278138
12NTRK22.23088656
13SIK31.94763351
14MINK11.90506014
15PRPF4B1.90082037
16MAPK131.84015212
17CAMKK21.67467327
18ERBB31.62415592
19CSNK1G31.61611470
20YES11.47002923
21BMPR1B1.46563488
22CSNK1A1L1.44438804
23CSNK1G11.43600933
24MAP3K91.35808161
25BCR1.35043937
26SRPK11.30634671
27PAK61.25367625
28DAPK21.20985543
29AKT31.18793792
30CDK51.13096625
31DYRK31.11070141
32DAPK11.09790866
33FRK1.09402333
34INSRR1.09353353
35KSR11.09317837
36CAMK2A1.08969696
37UHMK11.05303992
38MAP2K41.04918303
39WEE11.04714556
40NTRK11.04535038
41OXSR11.02528760
42PHKG21.00359913
43PHKG11.00359913
44PRKCG0.98444500
45CDK190.97043092
46MAP3K120.96343556
47DYRK1A0.94407909
48CDC70.94287019
49CCNB10.92412571
50BMPR20.91804729
51LATS20.91430673
52GRK50.91078646
53BUB10.90307895
54CAMKK10.87772004
55SGK10.84654151
56NEK60.83501466
57NUAK10.83287115
58TSSK60.81633884
59SGK2230.81418802
60SGK4940.81418802
61CDK180.80964778
62CAMK10.80385268
63CAMK2B0.76521859
64PTK2B0.76073271
65PRKCE0.76042348
66PLK40.75590292
67CSNK1G20.74773115
68STK380.73988415
69SIK20.73973825
70WNK40.73708377
71EPHB20.73699031
72NEK10.73601167
73MARK20.73036395
74CDK150.72436426
75MUSK0.72144302
76PLK30.69869919
77CDK140.69278388
78ATR0.68745755
79PKN10.67413184
80SGK20.65665463
81CDK11A0.63779426
82CAMK2D0.62966696
83GRK10.61986830
84MKNK20.61579527
85MAP2K10.60802683
86ADRBK20.58690338
87PNCK0.58587025
88PRKG10.58216615
89MKNK10.57686625
90PLK10.55159289
91TYRO30.52519152
92PAK30.52262783
93BRSK20.52132630
94TNK20.51604766
95PRKCB0.51078293
96BCKDK0.50753299
97GSK3B0.50379671
98STK390.49455961
99ADRBK10.49063170
100RPS6KA40.48645974
101CSNK1A10.48348690
102CAMK1D0.48041402
103BRD40.46599497
104PRKD30.46586273
105ATM0.46491735
106CDK30.45877861
107CSNK1D0.45359410
108PRKCZ0.44949468
109MAP3K130.44752831
110DYRK20.43647392
111STK110.43398956
112VRK10.42267665
113RPS6KA30.42261660
114PINK10.39884372
115DYRK1B0.39711969
116MAPK100.39386231
117PRKDC0.39228192
118PRKCA0.38375247
119CAMK1G0.38370182
120CAMK40.37770124
121EPHA30.37511377
122RIPK40.37365242
123ABL10.37024261
124MAPK90.35630605
125MAPK80.35157611
126PRKCH0.34619888
127BRSK10.34327073
128PRKACA0.34316684
129ROCK20.33628429
130CSNK1E0.33309135
131GRK70.33034011
132WNK10.32827663
133WNK30.30585686
134PRKACB0.29270014
135CAMK2G0.29044020
136RPS6KB10.28846745
137NME10.28666736

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.94306726
2Synaptic vesicle cycle_Homo sapiens_hsa047213.30473241
3Glutamatergic synapse_Homo sapiens_hsa047243.11736670
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.02732123
5GABAergic synapse_Homo sapiens_hsa047272.88967054
6Circadian entrainment_Homo sapiens_hsa047132.86208942
7Long-term potentiation_Homo sapiens_hsa047202.74303600
8Amphetamine addiction_Homo sapiens_hsa050312.65841378
9Morphine addiction_Homo sapiens_hsa050322.33833233
10* Protein export_Homo sapiens_hsa030602.23922076
11Collecting duct acid secretion_Homo sapiens_hsa049662.22302605
12Long-term depression_Homo sapiens_hsa047302.17986524
13Cocaine addiction_Homo sapiens_hsa050302.16818278
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15097981
15Dopaminergic synapse_Homo sapiens_hsa047282.10118079
16Olfactory transduction_Homo sapiens_hsa047402.09438087
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.95784842
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.90544395
19Fanconi anemia pathway_Homo sapiens_hsa034601.83475823
20Axon guidance_Homo sapiens_hsa043601.83409101
21Taste transduction_Homo sapiens_hsa047421.83078099
22Serotonergic synapse_Homo sapiens_hsa047261.83040950
23Steroid biosynthesis_Homo sapiens_hsa001001.71292252
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66212076
25Insulin secretion_Homo sapiens_hsa049111.59336743
26Salivary secretion_Homo sapiens_hsa049701.52548604
27Calcium signaling pathway_Homo sapiens_hsa040201.52247117
28Cholinergic synapse_Homo sapiens_hsa047251.44449552
29Renin secretion_Homo sapiens_hsa049241.36147080
30Butanoate metabolism_Homo sapiens_hsa006501.33833859
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32160912
32Non-homologous end-joining_Homo sapiens_hsa034501.31604037
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30781144
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.30242355
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27817694
36Oxytocin signaling pathway_Homo sapiens_hsa049211.27501076
37* Vibrio cholerae infection_Homo sapiens_hsa051101.27302044
38Propanoate metabolism_Homo sapiens_hsa006401.22953727
39Oocyte meiosis_Homo sapiens_hsa041141.17528022
40Homologous recombination_Homo sapiens_hsa034401.17287198
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12592560
42RNA degradation_Homo sapiens_hsa030181.12296724
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10842855
44mRNA surveillance pathway_Homo sapiens_hsa030151.08956093
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08008644
46cAMP signaling pathway_Homo sapiens_hsa040241.06234475
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05677936
48Cardiac muscle contraction_Homo sapiens_hsa042601.03938914
49Gastric acid secretion_Homo sapiens_hsa049710.99652799
50Mismatch repair_Homo sapiens_hsa034300.99268666
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97389085
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94225231
53Phototransduction_Homo sapiens_hsa047440.92760014
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91401880
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91208155
56Oxidative phosphorylation_Homo sapiens_hsa001900.91048447
57Gap junction_Homo sapiens_hsa045400.85336579
58GnRH signaling pathway_Homo sapiens_hsa049120.83810103
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83424252
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83106465
61ErbB signaling pathway_Homo sapiens_hsa040120.80867162
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79581660
63Basal cell carcinoma_Homo sapiens_hsa052170.78305894
64RNA transport_Homo sapiens_hsa030130.77736765
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75839788
66Melanogenesis_Homo sapiens_hsa049160.75704086
67Hippo signaling pathway_Homo sapiens_hsa043900.75539078
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74971143
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74851648
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.73264274
71Ether lipid metabolism_Homo sapiens_hsa005650.72718812
72Dilated cardiomyopathy_Homo sapiens_hsa054140.70530634
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70521570
74Spliceosome_Homo sapiens_hsa030400.68712566
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68310404
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67537242
77Type II diabetes mellitus_Homo sapiens_hsa049300.66942645
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.66786309
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66190561
80Circadian rhythm_Homo sapiens_hsa047100.66070341
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65555493
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65472400
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65415749
84Alzheimers disease_Homo sapiens_hsa050100.64234518
85Selenocompound metabolism_Homo sapiens_hsa004500.63543615
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63030132
87Alcoholism_Homo sapiens_hsa050340.60863900
88Sphingolipid metabolism_Homo sapiens_hsa006000.60420048
89Regulation of autophagy_Homo sapiens_hsa041400.60232261
90Cell cycle_Homo sapiens_hsa041100.58296823
91beta-Alanine metabolism_Homo sapiens_hsa004100.57693768
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57547156
93MAPK signaling pathway_Homo sapiens_hsa040100.56668073
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56160484
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55365769
96Arginine biosynthesis_Homo sapiens_hsa002200.55075081
97Huntingtons disease_Homo sapiens_hsa050160.53872404
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53622565
99Wnt signaling pathway_Homo sapiens_hsa043100.52314118
100Parkinsons disease_Homo sapiens_hsa050120.51932959
101Fatty acid elongation_Homo sapiens_hsa000620.51662459
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50895959
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49872549
104Rheumatoid arthritis_Homo sapiens_hsa053230.49459095
105Ras signaling pathway_Homo sapiens_hsa040140.49391305
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48886220
107Estrogen signaling pathway_Homo sapiens_hsa049150.48805205
108RNA polymerase_Homo sapiens_hsa030200.47381340
109Proteasome_Homo sapiens_hsa030500.46737409
110Folate biosynthesis_Homo sapiens_hsa007900.46060720
111Hedgehog signaling pathway_Homo sapiens_hsa043400.45432774
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.43867730
113Ovarian steroidogenesis_Homo sapiens_hsa049130.43421876
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43298949
115Type I diabetes mellitus_Homo sapiens_hsa049400.40007241
116Glucagon signaling pathway_Homo sapiens_hsa049220.38782189
117Nucleotide excision repair_Homo sapiens_hsa034200.38473898
118Nitrogen metabolism_Homo sapiens_hsa009100.37288613
119Choline metabolism in cancer_Homo sapiens_hsa052310.36146830
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.35915514
121Vitamin B6 metabolism_Homo sapiens_hsa007500.35914286
122Peroxisome_Homo sapiens_hsa041460.34979964
123Basal transcription factors_Homo sapiens_hsa030220.34549541
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33359536
125Glioma_Homo sapiens_hsa052140.33236535
126Thyroid hormone synthesis_Homo sapiens_hsa049180.31407017
127Pancreatic secretion_Homo sapiens_hsa049720.31285957
128Purine metabolism_Homo sapiens_hsa002300.29069278
129Base excision repair_Homo sapiens_hsa034100.29023850
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.28681650
131MicroRNAs in cancer_Homo sapiens_hsa052060.26285069
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25104542
133Rap1 signaling pathway_Homo sapiens_hsa040150.23309929
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22799003

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