SEC61B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.42060972
2* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.15324203
3* protein targeting to ER (GO:0045047)6.03165241
4* cotranslational protein targeting to membrane (GO:0006613)6.00146178
5viral transcription (GO:0019083)5.72954858
6* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.71778219
7* protein localization to endoplasmic reticulum (GO:0070972)5.70777484
8signal peptide processing (GO:0006465)5.58610383
9DNA deamination (GO:0045006)5.52597384
10translational termination (GO:0006415)5.51673635
11COPI coating of Golgi vesicle (GO:0048205)5.34475301
12Golgi transport vesicle coating (GO:0048200)5.34475301
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.30481501
14ribosomal small subunit biogenesis (GO:0042274)5.19743830
15chaperone-mediated protein transport (GO:0072321)5.11455503
16respiratory electron transport chain (GO:0022904)5.06284568
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.98941067
18electron transport chain (GO:0022900)4.95251040
19translational elongation (GO:0006414)4.79676022
20protein complex biogenesis (GO:0070271)4.47487872
21viral life cycle (GO:0019058)4.41643623
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.41514799
23mitochondrial respiratory chain complex assembly (GO:0033108)4.24384141
24protein neddylation (GO:0045116)4.24033207
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.17598363
26cellular protein complex disassembly (GO:0043624)4.16968215
27translational initiation (GO:0006413)4.16520227
28protein retention in ER lumen (GO:0006621)4.10337144
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.08715781
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.08715781
31NADH dehydrogenase complex assembly (GO:0010257)4.08715781
32* translation (GO:0006412)4.07810184
33* protein targeting to membrane (GO:0006612)3.94510699
34protein targeting to mitochondrion (GO:0006626)3.88992284
35GDP-mannose metabolic process (GO:0019673)3.85348686
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.83393901
37maturation of SSU-rRNA (GO:0030490)3.76540591
38protein maturation by protein folding (GO:0022417)3.74289728
39protein complex disassembly (GO:0043241)3.64951277
40establishment of protein localization to mitochondrion (GO:0072655)3.63097887
41cullin deneddylation (GO:0010388)3.62316185
42positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.60493243
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.58613133
44RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.58613133
45ribosomal large subunit biogenesis (GO:0042273)3.57724676
46protein localization to mitochondrion (GO:0070585)3.52767517
47protein deneddylation (GO:0000338)3.52058486
48positive regulation of ligase activity (GO:0051351)3.48032656
49macromolecular complex disassembly (GO:0032984)3.46720043
50oxidative phosphorylation (GO:0006119)3.30356464
51rRNA modification (GO:0000154)3.29394494
52hydrogen ion transmembrane transport (GO:1902600)3.27949953
53deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.25705741
54* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18940522
55formation of translation preinitiation complex (GO:0001731)3.18229371
56regulation of cellular amine metabolic process (GO:0033238)3.18228645
57proteasome assembly (GO:0043248)3.17490812
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.16368213
59purine nucleoside triphosphate biosynthetic process (GO:0009145)3.14888218
60pteridine-containing compound biosynthetic process (GO:0042559)3.14439325
61telomere maintenance via semi-conservative replication (GO:0032201)3.12260638
62sequestering of metal ion (GO:0051238)3.12180630
63ATP biosynthetic process (GO:0006754)3.11816802
64regulation of ubiquitin-protein transferase activity (GO:0051438)3.11755348
65* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.11398751
66purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.10145556
67positive regulation of cell cycle arrest (GO:0071158)3.06680587
68mitochondrial transport (GO:0006839)3.05410399
69GTP biosynthetic process (GO:0006183)3.04853278
70regulation of ligase activity (GO:0051340)3.03435497
71mRNA catabolic process (GO:0006402)3.02661064
72DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.01387797
73proton transport (GO:0015992)2.97994925
74ribonucleoprotein complex biogenesis (GO:0022613)2.97667477
75folic acid-containing compound biosynthetic process (GO:0009396)2.91328140
76hydrogen transport (GO:0006818)2.90732241
77COPII vesicle coating (GO:0048208)2.89400715
78deoxyribonucleotide catabolic process (GO:0009264)2.88174437
79negative regulation of protein ubiquitination (GO:0031397)2.86725698
80DNA strand elongation involved in DNA replication (GO:0006271)2.86686399
81mannosylation (GO:0097502)2.83871230
82RNA catabolic process (GO:0006401)2.83501849
83deoxyribose phosphate biosynthetic process (GO:0046385)2.82525747
842-deoxyribonucleotide biosynthetic process (GO:0009265)2.82525747
85nucleobase-containing small molecule interconversion (GO:0015949)2.82007408
86deoxyribose phosphate catabolic process (GO:0046386)2.81963001
87* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.81497561
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80256669
89ribonucleoside triphosphate biosynthetic process (GO:0009201)2.78960793
90rRNA metabolic process (GO:0016072)2.76535740
91purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.76289384
92DNA strand elongation (GO:0022616)2.75204524
93telomere maintenance via recombination (GO:0000722)2.73520184
94exocrine pancreas development (GO:0031017)2.72747741
95mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.71936924
96* establishment of protein localization to membrane (GO:0090150)2.69880564
97peptidyl-histidine modification (GO:0018202)2.68317207
98proline biosynthetic process (GO:0006561)2.65292860
99endocrine pancreas development (GO:0031018)2.64624265
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62627574
101respiratory chain complex IV assembly (GO:0008535)2.61916013
102energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61895138
103ATP synthesis coupled proton transport (GO:0015986)2.61895138
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61490368
105* protein targeting (GO:0006605)2.60767565
106guanosine-containing compound biosynthetic process (GO:1901070)2.58541079
107regulation of cellular amino acid metabolic process (GO:0006521)2.58500966
108cellular component biogenesis (GO:0044085)2.58185277
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57535818
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.57334950
111termination of RNA polymerase III transcription (GO:0006386)2.57334950
112intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.57138269
113signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.57138269
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.55675287
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.55675287
116signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.55675287
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.55300384
118regulation of mitochondrial translation (GO:0070129)2.53599626
119negative regulation of ligase activity (GO:0051352)2.52621288
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.52621288
121pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.50012712
122protein N-linked glycosylation via asparagine (GO:0018279)2.49502223
123rRNA processing (GO:0006364)2.49195977
124regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.48778182
125pseudouridine synthesis (GO:0001522)2.47915847
126response to interferon-beta (GO:0035456)2.46779408
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46276704
128antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45740655
129antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45740655
130pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.45711002
131signal transduction involved in DNA integrity checkpoint (GO:0072401)2.45632092
132signal transduction involved in DNA damage checkpoint (GO:0072422)2.45632092
133* establishment of protein localization to organelle (GO:0072594)2.44816528
134deoxyribonucleotide biosynthetic process (GO:0009263)2.43793656
135cytochrome complex assembly (GO:0017004)2.43477875
136peptidyl-asparagine modification (GO:0018196)2.43464326
137spliceosomal snRNP assembly (GO:0000387)2.43078852
138signal transduction involved in cell cycle checkpoint (GO:0072395)2.42235692
139retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41238971
140dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.39509955
141reactive oxygen species biosynthetic process (GO:1903409)2.38761399
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.37525035
143metallo-sulfur cluster assembly (GO:0031163)2.37242432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.92100446
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.80651600
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.72933822
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62777006
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.61866101
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.52203290
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.30743201
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24754416
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15825030
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08685448
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.86578179
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69688430
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67840516
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67295655
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66431398
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59030388
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.40528565
18* VDR_23849224_ChIP-Seq_CD4+_Human2.34693696
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34519524
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28850594
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27659466
22XRN2_22483619_ChIP-Seq_HELA_Human2.22774397
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.18496390
24DCP1A_22483619_ChIP-Seq_HELA_Human2.18147205
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.15229226
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14807504
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14749307
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11463834
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09804756
30ELK1_19687146_ChIP-ChIP_HELA_Human2.03588141
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.00538826
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97198825
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.94441697
34GABP_19822575_ChIP-Seq_HepG2_Human1.93717779
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91833616
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90621795
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90277981
38* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.89746350
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85296739
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.85223264
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79422969
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77616730
43* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77081227
44* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75944464
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73877440
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70077266
47TTF2_22483619_ChIP-Seq_HELA_Human1.69264650
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58234542
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.56479343
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56352947
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54785973
52SPI1_23547873_ChIP-Seq_NB4_Human1.52702944
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42634768
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.42226740
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38218246
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32213925
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31825119
58TFEB_21752829_ChIP-Seq_HELA_Human1.31473018
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28613167
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27139314
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26900979
62* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24075452
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24003592
64VDR_21846776_ChIP-Seq_THP-1_Human1.21921586
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20399771
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20089844
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.19235154
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.19207728
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17653769
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17152491
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15741611
72CIITA_25753668_ChIP-Seq_RAJI_Human1.15686051
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15359696
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.15118630
75KDM5A_27292631_Chip-Seq_BREAST_Human1.14936222
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14166697
77PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12780662
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09588898
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09534230
80MYC_22102868_ChIP-Seq_BL_Human1.09144327
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08776005
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08658742
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07520704
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05855657
85* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04526864
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04334776
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04096579
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.02269629
89* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02077465
90EGR1_19374776_ChIP-ChIP_THP-1_Human0.99919459
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99819145
92CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96544295
93PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91996129
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91592070
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91543562
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90100923
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89873492
98FOXM1_23109430_ChIP-Seq_U2OS_Human0.89267528
99MYC_18940864_ChIP-ChIP_HL60_Human0.88642848
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86749246
101ELF5_23300383_ChIP-Seq_T47D_Human0.86479750
102GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86319150
103MYB_26560356_Chip-Seq_TH2_Human0.86287691
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85778108
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84156851
106GATA1_22025678_ChIP-Seq_K562_Human0.84064295
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83558176
108* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82417468
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82264486
110TP53_22573176_ChIP-Seq_HFKS_Human0.82180354
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78955525
112FLI1_27457419_Chip-Seq_LIVER_Mouse0.75458009
113ZNF274_21170338_ChIP-Seq_K562_Hela0.74792111
114AR_20517297_ChIP-Seq_VCAP_Human0.72687433
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.72143649
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.68095790
117IRF1_19129219_ChIP-ChIP_H3396_Human0.67398851
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67248358
119FOXA1_25329375_ChIP-Seq_VCAP_Human0.67216217
120FOXA1_27270436_Chip-Seq_PROSTATE_Human0.67216217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.59359359
2MP0009379_abnormal_foot_pigmentation2.58548547
3MP0005220_abnormal_exocrine_pancreas2.57287292
4MP0001835_abnormal_antigen_presentation2.48994119
5MP0002693_abnormal_pancreas_physiology2.35461196
6MP0003718_maternal_effect2.34662710
7MP0004957_abnormal_blastocyst_morpholog2.28148429
8MP0002877_abnormal_melanocyte_morpholog2.17819642
9MP0002148_abnormal_hypersensitivity_rea2.11705466
10MP0003436_decreased_susceptibility_to2.07521445
11MP0003186_abnormal_redox_activity2.06423719
12MP0009785_altered_susceptibility_to2.05088499
13MP0002139_abnormal_hepatobiliary_system2.04507296
14MP0001944_abnormal_pancreas_morphology2.00355766
15MP0006072_abnormal_retinal_apoptosis1.94827426
16MP0005671_abnormal_response_to1.91377142
17MP0003724_increased_susceptibility_to1.90931064
18MP0005084_abnormal_gallbladder_morpholo1.89269125
19MP0000490_abnormal_crypts_of1.82661252
20MP0005379_endocrine/exocrine_gland_phen1.82533262
21MP0006054_spinal_hemorrhage1.78678380
22MP0003183_abnormal_peptide_metabolism1.76917512
23MP0009333_abnormal_splenocyte_physiolog1.76395853
24MP0005645_abnormal_hypothalamus_physiol1.74324789
25MP0000685_abnormal_immune_system1.73795795
26MP0005000_abnormal_immune_tolerance1.69029069
27MP0005025_abnormal_response_to1.66687945
28MP0000678_abnormal_parathyroid_gland1.66431642
29MP0008875_abnormal_xenobiotic_pharmacok1.62280154
30MP0006035_abnormal_mitochondrial_morpho1.61946279
31MP0003283_abnormal_digestive_organ1.60781476
32MP0003195_calcinosis1.60319141
33MP0002254_reproductive_system_inflammat1.58036860
34MP0009697_abnormal_copulation1.57320781
35MP0002837_dystrophic_cardiac_calcinosis1.56262756
36MP0001529_abnormal_vocalization1.56083125
37MP0006082_CNS_inflammation1.55200611
38MP0003763_abnormal_thymus_physiology1.54517211
39MP0002876_abnormal_thyroid_physiology1.53887590
40MP0010386_abnormal_urinary_bladder1.52932563
41MP0002163_abnormal_gland_morphology1.49124273
42MP0003806_abnormal_nucleotide_metabolis1.48388525
43MP0003077_abnormal_cell_cycle1.47138639
44MP0008058_abnormal_DNA_repair1.46043057
45MP0000858_altered_metastatic_potential1.45448296
46MP0002419_abnormal_innate_immunity1.40906603
47MP0003011_delayed_dark_adaptation1.40568461
48MP0005408_hypopigmentation1.40260801
49MP0002723_abnormal_immune_serum1.39924353
50MP0000613_abnormal_salivary_gland1.38940553
51MP0001845_abnormal_inflammatory_respons1.38212277
52MP0005332_abnormal_amino_acid1.37651548
53MP0001819_abnormal_immune_cell1.37172044
54MP0002420_abnormal_adaptive_immunity1.36526544
55MP0001986_abnormal_taste_sensitivity1.35664480
56MP0002452_abnormal_antigen_presenting1.34996104
57MP0008007_abnormal_cellular_replicative1.34981017
58MP0008789_abnormal_olfactory_epithelium1.34789072
59MP0002405_respiratory_system_inflammati1.34643054
60MP0010094_abnormal_chromosome_stability1.29898322
61MP0002166_altered_tumor_susceptibility1.29496525
62MP0002138_abnormal_hepatobiliary_system1.29215736
63MP0010155_abnormal_intestine_physiology1.28581331
64MP0001790_abnormal_immune_system1.28529531
65MP0005387_immune_system_phenotype1.28529531
66MP0003866_abnormal_defecation1.27369916
67MP0001800_abnormal_humoral_immune1.27126933
68MP0004043_abnormal_pH_regulation1.26640195
69MP0008932_abnormal_embryonic_tissue1.26279046
70MP0001919_abnormal_reproductive_system1.23731997
71MP0009764_decreased_sensitivity_to1.21911080
72MP0002638_abnormal_pupillary_reflex1.21040412
73MP0002398_abnormal_bone_marrow1.19599206
74MP0009643_abnormal_urine_homeostasis1.19551912
75MP0008995_early_reproductive_senescence1.19107701
76MP0002396_abnormal_hematopoietic_system1.18624283
77MP0002132_abnormal_respiratory_system1.17278362
78MP0001905_abnormal_dopamine_level1.16180038
79MP0005083_abnormal_biliary_tract1.16068032
80MP0002006_tumorigenesis1.15516294
81MP0005636_abnormal_mineral_homeostasis1.15478430
82MP0000716_abnormal_immune_system1.14658322
83MP0002102_abnormal_ear_morphology1.14355668
84MP0001666_abnormal_nutrient_absorption1.14046472
85MP0001881_abnormal_mammary_gland1.14042760
86MP0005389_reproductive_system_phenotype1.12748856
87MP0004264_abnormal_extraembryonic_tissu1.12368417
88MP0008469_abnormal_protein_level1.11961070
89MP0001873_stomach_inflammation1.10970033
90MP0001853_heart_inflammation1.10508916
91MP0002277_abnormal_respiratory_mucosa1.09411912
92MP0002429_abnormal_blood_cell1.09042948
93MP0002722_abnormal_immune_system1.06454591
94MP0005319_abnormal_enzyme/_coenzyme1.05937450
95MP0001533_abnormal_skeleton_physiology1.05791667
96MP0001542_abnormal_bone_strength1.05566258
97MP0004782_abnormal_surfactant_physiolog1.04514817
98MP0009840_abnormal_foam_cell1.04462407
99MP0002938_white_spotting1.04256503
100MP0006292_abnormal_olfactory_placode1.03422692
101MP0000689_abnormal_spleen_morphology1.02878787
102MP0005058_abnormal_lysosome_morphology1.02596190
103MP0002019_abnormal_tumor_incidence1.01547858
104MP0008872_abnormal_physiological_respon1.01277681
105MP0005310_abnormal_salivary_gland1.01230453
106MP0005360_urolithiasis1.01077755
107MP0005075_abnormal_melanosome_morpholog0.99673450
108MP0006036_abnormal_mitochondrial_physio0.99588590
109MP0005174_abnormal_tail_pigmentation0.99152697
110MP0003111_abnormal_nucleus_morphology0.98755974
111MP0008877_abnormal_DNA_methylation0.97294656
112MP0005464_abnormal_platelet_physiology0.97238118
113MP0004147_increased_porphyrin_level0.97091549
114MP0002933_joint_inflammation0.94748174
115MP0004142_abnormal_muscle_tone0.92974783
116MP0002090_abnormal_vision0.92299378
117MP0000013_abnormal_adipose_tissue0.92171933
118MP0000372_irregular_coat_pigmentation0.90903710
119MP0001764_abnormal_homeostasis0.90449338
120MP0001727_abnormal_embryo_implantation0.90416700
121MP0002928_abnormal_bile_duct0.89178256
122MP0005365_abnormal_bile_salt0.89142589
123MP0005395_other_phenotype0.87802239
124MP0003786_premature_aging0.87107363
125MP0000703_abnormal_thymus_morphology0.86985433
126MP0000358_abnormal_cell_content/0.86497357
127MP0000313_abnormal_cell_death0.85585149
128MP0005410_abnormal_fertilization0.85363545
129MP0000681_abnormal_thyroid_gland0.84572788
130MP0000465_gastrointestinal_hemorrhage0.83967124
131MP0008057_abnormal_DNA_replication0.83612706
132MP0005253_abnormal_eye_physiology0.83523848
133MP0008873_increased_physiological_sensi0.81407001
134MP0003795_abnormal_bone_structure0.78451426
135MP0002095_abnormal_skin_pigmentation0.78171927
136MP0003123_paternal_imprinting0.77431690
137MP0002078_abnormal_glucose_homeostasis0.75512468
138MP0009763_increased_sensitivity_to0.75303758
139MP0001756_abnormal_urination0.74973618
140MP0004019_abnormal_vitamin_homeostasis0.73753143
141MP0001119_abnormal_female_reproductive0.73343962

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.04314526
2Abnormal number of erythroid precursors (HP:0012131)4.71993502
3Reticulocytopenia (HP:0001896)4.48336178
4Type I transferrin isoform profile (HP:0003642)4.36212460
5Cerebral edema (HP:0002181)4.33351950
6Aplastic anemia (HP:0001915)3.99730458
7Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.79432455
8Abnormal protein N-linked glycosylation (HP:0012347)3.79432455
9Abnormal protein glycosylation (HP:0012346)3.79432455
10Abnormal glycosylation (HP:0012345)3.79432455
11Reduced antithrombin III activity (HP:0001976)3.65186613
12Hypoglycemic coma (HP:0001325)3.40807301
13Thrombocytosis (HP:0001894)3.32572712
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.30173867
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.30173867
16Pallor (HP:0000980)3.20638652
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.20546000
18Macrocytic anemia (HP:0001972)3.19054653
19Hepatic necrosis (HP:0002605)3.12407535
20Generalized aminoaciduria (HP:0002909)3.09965425
21Hypoglycemic seizures (HP:0002173)3.08207049
22Vacuolated lymphocytes (HP:0001922)3.02067917
23Exertional dyspnea (HP:0002875)2.90647209
24Mitochondrial inheritance (HP:0001427)2.90559704
25Methylmalonic aciduria (HP:0012120)2.86643774
26Symptomatic seizures (HP:0011145)2.84510814
27Leukodystrophy (HP:0002415)2.78474461
28Lethargy (HP:0001254)2.77483523
29Poor head control (HP:0002421)2.75561713
30Increased hepatocellular lipid droplets (HP:0006565)2.73685189
31Optic disc pallor (HP:0000543)2.72611304
32Hyperinsulinemic hypoglycemia (HP:0000825)2.72446376
33Acute necrotizing encephalopathy (HP:0006965)2.71233727
34Hepatocellular necrosis (HP:0001404)2.70806553
35Methylmalonic acidemia (HP:0002912)2.69098730
3611 pairs of ribs (HP:0000878)2.67929540
37Lipid accumulation in hepatocytes (HP:0006561)2.66956872
38Dicarboxylic aciduria (HP:0003215)2.64477634
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64477634
40Abnormal mitochondria in muscle tissue (HP:0008316)2.62288019
41Elevated erythrocyte sedimentation rate (HP:0003565)2.55313158
42Renal Fanconi syndrome (HP:0001994)2.48690125
43Late onset (HP:0003584)2.48342203
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46543546
45Increased intramyocellular lipid droplets (HP:0012240)2.42147093
46Abnormality of T cell physiology (HP:0011840)2.41651255
47CNS demyelination (HP:0007305)2.41204180
48Recurrent abscess formation (HP:0002722)2.40739528
49Increased CSF lactate (HP:0002490)2.37960492
50Microretrognathia (HP:0000308)2.30642404
51Increased serum pyruvate (HP:0003542)2.27942557
52IgM deficiency (HP:0002850)2.27513943
53Acute encephalopathy (HP:0006846)2.27404887
54Abnormality of methionine metabolism (HP:0010901)2.26796688
55Congenital, generalized hypertrichosis (HP:0004540)2.25778315
56Increased muscle lipid content (HP:0009058)2.21421366
57Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21418492
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20698888
59Abnormality of the intrinsic pathway (HP:0010989)2.20496660
60Recurrent bacterial skin infections (HP:0005406)2.20377561
61Petechiae (HP:0000967)2.19378150
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.19237156
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.18583591
64Abnormal hemoglobin (HP:0011902)2.15307928
65Abnormality of the anterior horn cell (HP:0006802)2.14695539
66Degeneration of anterior horn cells (HP:0002398)2.14695539
67Nausea (HP:0002018)2.14068128
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12220003
69Glycosuria (HP:0003076)2.06197504
70Abnormality of urine glucose concentration (HP:0011016)2.06197504
71Emotional lability (HP:0000712)2.05598476
72X-linked dominant inheritance (HP:0001423)2.04281814
73Hyperphosphaturia (HP:0003109)2.02013135
74Oral leukoplakia (HP:0002745)2.00380579
75Eczematoid dermatitis (HP:0000976)1.99516117
76Thoracolumbar scoliosis (HP:0002944)1.99409600
77Cleft eyelid (HP:0000625)1.99181607
78Myositis (HP:0100614)1.97203156
79Dysostosis multiplex (HP:0000943)1.95580177
80Abnormality of glycolysis (HP:0004366)1.95130621
81Progressive macrocephaly (HP:0004481)1.93306315
82Beaking of vertebral bodies (HP:0004568)1.93209606
83Abnormality of endocrine pancreas physiology (HP:0012093)1.93165102
84Abnormality of the pancreatic islet cells (HP:0006476)1.93165102
85Testicular atrophy (HP:0000029)1.89935509
86Progressive neurologic deterioration (HP:0002344)1.89880856
87Increased serum lactate (HP:0002151)1.89741834
88IgG deficiency (HP:0004315)1.89724642
89Abnormality of serum amino acid levels (HP:0003112)1.84244332
90Mucopolysacchariduria (HP:0008155)1.83189062
91Urinary glycosaminoglycan excretion (HP:0003541)1.83189062
92Abnormality of T cells (HP:0002843)1.81935579
933-Methylglutaconic aciduria (HP:0003535)1.81457749
94Vomiting (HP:0002013)1.81086811
95Flat capital femoral epiphysis (HP:0003370)1.80041971
96Exercise intolerance (HP:0003546)1.78361994
97Rough bone trabeculation (HP:0100670)1.77235026
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77090837
99Sparse eyelashes (HP:0000653)1.76190922
100Pancytopenia (HP:0001876)1.76132150
101Hyperglycinemia (HP:0002154)1.75123286
102Abnormal pancreas size (HP:0012094)1.75006870
103Multiple enchondromatosis (HP:0005701)1.74674166
104Abnormality of renal resorption (HP:0011038)1.74281591
105Amniotic constriction ring (HP:0009775)1.74209837
106Abnormality of placental membranes (HP:0011409)1.74209837
107Hypothermia (HP:0002045)1.73900118
108Blindness (HP:0000618)1.71583832
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71305476
110Abnormality of alanine metabolism (HP:0010916)1.71305476
111Hyperalaninemia (HP:0003348)1.71305476
112Lactic acidosis (HP:0003128)1.71068870
113Neutropenia (HP:0001875)1.70706415
114Premature graying of hair (HP:0002216)1.70525250
115Hyperparathyroidism (HP:0000843)1.69655383
116Abnormality of vitamin B metabolism (HP:0004340)1.68672659
117Depressed nasal ridge (HP:0000457)1.67194570
118Trismus (HP:0000211)1.66451115
119Progressive microcephaly (HP:0000253)1.66313510
120Respiratory difficulties (HP:0002880)1.65479837
121Stomatitis (HP:0010280)1.64711144
122Congenital ichthyosiform erythroderma (HP:0007431)1.64456747
123Palpitations (HP:0001962)1.61163672
124Progressive muscle weakness (HP:0003323)1.60841155
125Meningitis (HP:0001287)1.60586268
126Aplasia/hypoplasia of the uterus (HP:0008684)1.60487919
127Abnormality of macrophages (HP:0004311)1.60307736
128Birth length less than 3rd percentile (HP:0003561)1.59496923
129Abnormal delayed hypersensitivity skin test (HP:0002963)1.59149486
130Microvesicular hepatic steatosis (HP:0001414)1.58590183
131Gliosis (HP:0002171)1.57702724
132Optic nerve coloboma (HP:0000588)1.57397882
133Abnormality of calcium-phosphate metabolism (HP:0100530)1.56967965
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.56399304
135Abnormality of polysaccharide metabolism (HP:0011012)1.56399304
136Abnormality of glycosaminoglycan metabolism (HP:0004371)1.56399304
137Respiratory failure (HP:0002878)1.56112603
138Hypoplasia of the uterus (HP:0000013)1.54658280
139Opisthotonus (HP:0002179)1.54586371
140Abnormality of the vitamin B12 metabolism (HP:0004341)1.53699436
141Abnormality of midbrain morphology (HP:0002418)1.53281666
142Molar tooth sign on MRI (HP:0002419)1.53281666
143Parakeratosis (HP:0001036)1.53245209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.55199255
2NME24.24807570
3STK163.21575010
4PASK3.18222493
5ERN12.89595389
6MAP3K122.81281196
7EIF2AK32.78994478
8PIM22.69203471
9TAOK32.67093371
10MAPK152.53278372
11IRAK32.19466404
12MAP4K22.19324630
13BCKDK2.10765509
14IRAK42.03167011
15BUB12.03101595
16TESK22.02240245
17VRK12.00221200
18FLT31.96993761
19NUAK11.87574633
20NEK11.84691825
21EIF2AK11.68303474
22WEE11.64829488
23ACVR1B1.64053952
24DYRK31.64048275
25TESK11.62923022
26TEC1.55328059
27TRIM281.54401068
28TLK11.53947336
29BRSK21.44013290
30SCYL21.41009831
31RPS6KA41.38288303
32PIK3CG1.36584503
33INSRR1.35228483
34BTK1.34272446
35KDR1.31106617
36BRAF1.30731460
37PDK21.28954452
38MYLK1.27027036
39MAP4K11.24651670
40BLK1.24204134
41MST41.23837945
42CSNK1G31.22291683
43SRPK11.20160969
44ZAP701.20150189
45ARAF1.19959845
46HIPK21.19086011
47RPS6KB21.14504442
48TYK21.13290597
49JAK31.11746280
50CDK191.08874913
51TBK11.08390744
52PLK41.06326252
53PBK1.06005612
54PLK31.04577389
55MAPKAPK31.03487099
56MAP2K21.02321645
57MAP3K141.00948318
58NME10.99098589
59CSNK1G10.98267936
60IKBKB0.95016791
61WNK30.94401577
62DAPK30.94316503
63NLK0.94307404
64MAP3K110.94249418
65GRK10.91791753
66CDK80.90835578
67CSNK1G20.87815587
68ABL20.86304825
69LIMK10.85314739
70AURKB0.85002461
71PIM10.84454146
72DAPK10.84030474
73LRRK20.80964142
74CDK70.80263408
75FRK0.75937832
76GRK70.75457218
77TGFBR10.75276997
78CSNK1A1L0.74227844
79BMPR1B0.73878376
80IRAK10.73044281
81EIF2AK20.71739870
82SYK0.71696488
83LYN0.70965595
84IKBKE0.70238354
85KIT0.68808816
86TXK0.68680669
87CDC70.66305486
88DYRK1B0.64036193
89TSSK60.63215380
90TTK0.60186088
91AURKA0.58728895
92PAK40.58317022
93PRKCI0.58043319
94PLK10.58009970
95ATR0.55778476
96CSNK2A10.55624138
97ERBB30.55605945
98MAP3K30.55494564
99MAP3K80.55320823
100DYRK20.53081049
101EPHA20.52908965
102OXSR10.52537447
103RPS6KA50.51973706
104PRKG20.51867891
105ILK0.51351483
106CHUK0.50848837
107MATK0.50322157
108ZAK0.47901034
109CLK10.46454778
110CSNK2A20.46428190
111ADRBK20.45752334
112CSK0.45541215
113ITK0.44437537
114TAOK20.43585626
115TAF10.42036453
116MKNK10.41818612
117BRSK10.41516601
118NEK90.39567503
119PAK10.39381837
120MAPKAPK20.39069482
121NEK20.38657532
122BMPR20.37288527
123STK240.37195254
124YES10.36993405
125STK40.35155868
126CHEK20.34519459
127CSNK1A10.33425597
128BCR0.32531893
129MKNK20.32442880
130LCK0.32063958
131CSF1R0.31684680
132MAP2K70.29694254

Predicted pathways (KEGG)

RankGene SetZ-score
1* Protein export_Homo sapiens_hsa030604.92637078
2Ribosome_Homo sapiens_hsa030104.90391257
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.88808357
4Proteasome_Homo sapiens_hsa030503.19417064
5DNA replication_Homo sapiens_hsa030302.92819714
6RNA polymerase_Homo sapiens_hsa030202.34375532
7Mismatch repair_Homo sapiens_hsa034302.23685720
8Pyrimidine metabolism_Homo sapiens_hsa002402.09618537
9Folate biosynthesis_Homo sapiens_hsa007902.07245852
10Oxidative phosphorylation_Homo sapiens_hsa001902.04338558
11* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.95321491
12Spliceosome_Homo sapiens_hsa030401.88785416
13Homologous recombination_Homo sapiens_hsa034401.86247338
14N-Glycan biosynthesis_Homo sapiens_hsa005101.84151358
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81610338
16Base excision repair_Homo sapiens_hsa034101.77549408
17Parkinsons disease_Homo sapiens_hsa050121.74829778
18Sulfur metabolism_Homo sapiens_hsa009201.74118927
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65103401
20Nucleotide excision repair_Homo sapiens_hsa034201.60361475
21Other glycan degradation_Homo sapiens_hsa005111.50968468
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46136012
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40673953
24One carbon pool by folate_Homo sapiens_hsa006701.31042261
25Huntingtons disease_Homo sapiens_hsa050161.28644283
26Fatty acid elongation_Homo sapiens_hsa000621.28579820
27Legionellosis_Homo sapiens_hsa051341.28274374
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24318736
29Antigen processing and presentation_Homo sapiens_hsa046121.22786954
30Cardiac muscle contraction_Homo sapiens_hsa042601.18616761
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16167823
32RNA transport_Homo sapiens_hsa030131.13416728
33Sulfur relay system_Homo sapiens_hsa041221.12558148
34Alzheimers disease_Homo sapiens_hsa050101.12023008
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12018959
36Selenocompound metabolism_Homo sapiens_hsa004501.11295310
37RNA degradation_Homo sapiens_hsa030181.10708412
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07005674
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03561046
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02739270
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97189122
42Type I diabetes mellitus_Homo sapiens_hsa049400.96362460
43Propanoate metabolism_Homo sapiens_hsa006400.96253902
44Basal transcription factors_Homo sapiens_hsa030220.96030911
45Non-homologous end-joining_Homo sapiens_hsa034500.95749397
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.95573474
47Fanconi anemia pathway_Homo sapiens_hsa034600.95191698
48Cell cycle_Homo sapiens_hsa041100.95050206
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94969150
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.94094128
51Purine metabolism_Homo sapiens_hsa002300.93764771
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93518317
53Galactose metabolism_Homo sapiens_hsa000520.93474279
54Collecting duct acid secretion_Homo sapiens_hsa049660.92005701
55p53 signaling pathway_Homo sapiens_hsa041150.87689486
56Peroxisome_Homo sapiens_hsa041460.86924980
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85141261
58Herpes simplex infection_Homo sapiens_hsa051680.79489219
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79471087
60Graft-versus-host disease_Homo sapiens_hsa053320.78751415
61Allograft rejection_Homo sapiens_hsa053300.76495156
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.74870471
63Primary immunodeficiency_Homo sapiens_hsa053400.74187690
64Systemic lupus erythematosus_Homo sapiens_hsa053220.73760773
65Epstein-Barr virus infection_Homo sapiens_hsa051690.73503379
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.70719804
67Pyruvate metabolism_Homo sapiens_hsa006200.70638323
68Caffeine metabolism_Homo sapiens_hsa002320.70594560
69Lysosome_Homo sapiens_hsa041420.70395481
70* Vibrio cholerae infection_Homo sapiens_hsa051100.70392145
71Glutathione metabolism_Homo sapiens_hsa004800.69725870
72Arachidonic acid metabolism_Homo sapiens_hsa005900.69588980
73Steroid biosynthesis_Homo sapiens_hsa001000.69051153
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.69042275
75Pentose phosphate pathway_Homo sapiens_hsa000300.69035683
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67471678
77Leishmaniasis_Homo sapiens_hsa051400.66822212
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65898127
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.65249902
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64404848
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63503171
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62200009
83Asthma_Homo sapiens_hsa053100.61932519
84Measles_Homo sapiens_hsa051620.60954877
85Linoleic acid metabolism_Homo sapiens_hsa005910.60734639
86Chemical carcinogenesis_Homo sapiens_hsa052040.60720334
87Butanoate metabolism_Homo sapiens_hsa006500.57962569
88Renin-angiotensin system_Homo sapiens_hsa046140.57426107
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55315375
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55064268
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53287989
92Tryptophan metabolism_Homo sapiens_hsa003800.50799455
93Carbon metabolism_Homo sapiens_hsa012000.50727689
94Metabolic pathways_Homo sapiens_hsa011000.50675119
95Regulation of autophagy_Homo sapiens_hsa041400.50380147
96Hematopoietic cell lineage_Homo sapiens_hsa046400.49980033
97Pertussis_Homo sapiens_hsa051330.48681640
98Apoptosis_Homo sapiens_hsa042100.47043844
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46143287
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45965092
101Vitamin B6 metabolism_Homo sapiens_hsa007500.44704959
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43672538
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42460657
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42385447
105Fat digestion and absorption_Homo sapiens_hsa049750.40610202
106Influenza A_Homo sapiens_hsa051640.40073025
107Viral carcinogenesis_Homo sapiens_hsa052030.37297747
108Viral myocarditis_Homo sapiens_hsa054160.37231651
109Thyroid cancer_Homo sapiens_hsa052160.36776563
110Fatty acid degradation_Homo sapiens_hsa000710.36644691
111Histidine metabolism_Homo sapiens_hsa003400.36431053
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36055115
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.34794643
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34087309
115Tyrosine metabolism_Homo sapiens_hsa003500.33872494
116Retinol metabolism_Homo sapiens_hsa008300.33371911
117Fructose and mannose metabolism_Homo sapiens_hsa000510.33124347
118Shigellosis_Homo sapiens_hsa051310.32926988
119Autoimmune thyroid disease_Homo sapiens_hsa053200.32634494
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32123002
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31118484
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29627315
123Arginine and proline metabolism_Homo sapiens_hsa003300.28215823
124Biosynthesis of amino acids_Homo sapiens_hsa012300.28056784
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28041823
126Malaria_Homo sapiens_hsa051440.26991961
127Starch and sucrose metabolism_Homo sapiens_hsa005000.26784769
128Fatty acid metabolism_Homo sapiens_hsa012120.26112596
129Phenylalanine metabolism_Homo sapiens_hsa003600.25835366
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25778321
131Hepatitis B_Homo sapiens_hsa051610.25771088
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25119762
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.24364685
134Rheumatoid arthritis_Homo sapiens_hsa053230.23198782
135Sphingolipid metabolism_Homo sapiens_hsa006000.23061325

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