SEC61G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.15217091
2ribosomal small subunit biogenesis (GO:0042274)7.88025840
3translational termination (GO:0006415)7.83060806
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.73589337
5energy coupled proton transport, down electrochemical gradient (GO:0015985)7.36103938
6ATP synthesis coupled proton transport (GO:0015986)7.36103938
7* cotranslational protein targeting to membrane (GO:0006613)7.26403820
8* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.22340618
9* protein targeting to ER (GO:0045047)7.17533951
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.86202774
11* protein localization to endoplasmic reticulum (GO:0070972)6.75343205
12translational elongation (GO:0006414)6.25811554
13cellular protein complex disassembly (GO:0043624)6.17011106
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.15764480
15viral life cycle (GO:0019058)6.15325312
16ribosomal small subunit assembly (GO:0000028)5.76707615
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.67828159
18maturation of SSU-rRNA (GO:0030490)5.56952131
19respiratory electron transport chain (GO:0022904)5.41984536
20protein neddylation (GO:0045116)5.38568564
21translational initiation (GO:0006413)5.36695570
22ribosomal large subunit biogenesis (GO:0042273)5.31291187
23electron transport chain (GO:0022900)5.28454384
24protein complex disassembly (GO:0043241)5.14620162
25GTP biosynthetic process (GO:0006183)5.00690409
26macromolecular complex disassembly (GO:0032984)4.90083779
27* protein targeting to membrane (GO:0006612)4.75794734
28* translation (GO:0006412)4.64381559
29chaperone-mediated protein transport (GO:0072321)4.36596139
30proteasome assembly (GO:0043248)4.26270408
31UTP biosynthetic process (GO:0006228)4.25114223
32sequestering of actin monomers (GO:0042989)4.16863928
33protein complex biogenesis (GO:0070271)4.13394016
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.11065013
35mitochondrial respiratory chain complex I assembly (GO:0032981)4.11065013
36NADH dehydrogenase complex assembly (GO:0010257)4.11065013
37transcription elongation from RNA polymerase III promoter (GO:0006385)4.03289612
38termination of RNA polymerase III transcription (GO:0006386)4.03289612
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.96417446
40nuclear-transcribed mRNA catabolic process (GO:0000956)3.89317052
41establishment of integrated proviral latency (GO:0075713)3.87371865
42central nervous system myelination (GO:0022010)3.73555647
43axon ensheathment in central nervous system (GO:0032291)3.73555647
44mitochondrial respiratory chain complex assembly (GO:0033108)3.73477280
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.72764336
46mRNA catabolic process (GO:0006402)3.68957890
47inner mitochondrial membrane organization (GO:0007007)3.67345428
48purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.62352848
49establishment of viral latency (GO:0019043)3.61373746
50UTP metabolic process (GO:0046051)3.57194991
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57179901
52spliceosomal complex assembly (GO:0000245)3.57163323
53guanosine-containing compound biosynthetic process (GO:1901070)3.54141475
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.52226057
55CTP metabolic process (GO:0046036)3.40721583
56CTP biosynthetic process (GO:0006241)3.40721583
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.38380866
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.38380866
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.38380866
60rRNA modification (GO:0000154)3.37648266
61* establishment of protein localization to membrane (GO:0090150)3.36830036
62ribonucleoprotein complex biogenesis (GO:0022613)3.34124236
637-methylguanosine mRNA capping (GO:0006370)3.33974389
64RNA capping (GO:0036260)3.32709021
657-methylguanosine RNA capping (GO:0009452)3.32709021
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.31641733
67* protein targeting (GO:0006605)3.28242544
68hydrogen ion transmembrane transport (GO:1902600)3.28117401
69CENP-A containing nucleosome assembly (GO:0034080)3.25928169
70signal transduction involved in DNA integrity checkpoint (GO:0072401)3.25868094
71signal transduction involved in DNA damage checkpoint (GO:0072422)3.25868094
72RNA catabolic process (GO:0006401)3.25437210
73signal transduction involved in cell cycle checkpoint (GO:0072395)3.23536835
74oxidative phosphorylation (GO:0006119)3.23511181
75ATP biosynthetic process (GO:0006754)3.22827831
76cellular component biogenesis (GO:0044085)3.21898319
77intracellular protein transmembrane import (GO:0044743)3.19850368
78chromatin remodeling at centromere (GO:0031055)3.19421219
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17997594
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17997594
81ribonucleoside triphosphate biosynthetic process (GO:0009201)3.14768572
82spliceosomal snRNP assembly (GO:0000387)3.13781359
83positive regulation of ligase activity (GO:0051351)3.13653038
84DNA damage response, detection of DNA damage (GO:0042769)3.07438938
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07297122
86organelle disassembly (GO:1903008)3.03202281
87protein targeting to mitochondrion (GO:0006626)3.01884249
88mitochondrial transport (GO:0006839)3.01764041
89cytochrome complex assembly (GO:0017004)3.01315774
90regulation of mitochondrial translation (GO:0070129)3.00797346
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98283619
92establishment of protein localization to mitochondrion (GO:0072655)2.97608573
93cullin deneddylation (GO:0010388)2.97597470
94* establishment of protein localization to organelle (GO:0072594)2.96676042
95pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.95963635
96pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.95525094
97proton transport (GO:0015992)2.93184559
98rRNA processing (GO:0006364)2.88869041
99negative regulation of ligase activity (GO:0051352)2.88500419
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.88500419
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88143959
102nucleoside diphosphate phosphorylation (GO:0006165)2.84794921
103regulation of cellular amino acid metabolic process (GO:0006521)2.84480379
104hydrogen transport (GO:0006818)2.84477297
105respiratory chain complex IV assembly (GO:0008535)2.82000680
106signal peptide processing (GO:0006465)2.80696435
107transcription elongation from RNA polymerase I promoter (GO:0006362)2.77337563
108rRNA metabolic process (GO:0016072)2.75063558
109limb bud formation (GO:0060174)2.72414576
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.70699566
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70645331
112peptidyl-histidine modification (GO:0018202)2.70619747
113pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.70523005
114* protein localization to membrane (GO:0072657)2.68009165
115nucleoside triphosphate biosynthetic process (GO:0009142)2.67432187
116protein localization to mitochondrion (GO:0070585)2.66286195
117short-term memory (GO:0007614)2.65299759
118protein deneddylation (GO:0000338)2.64387413
119protein-cofactor linkage (GO:0018065)2.63607515
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.62018772
121signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.62018772
122viral protein processing (GO:0019082)2.59110573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.10676732
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.61073854
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.48246041
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.17503137
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.71377039
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.44205714
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06664979
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.99462041
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98325137
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.96268444
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.93148872
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89608366
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88675216
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51116105
15EZH2_22144423_ChIP-Seq_EOC_Human2.34758964
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32521145
17VDR_22108803_ChIP-Seq_LS180_Human2.30907064
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30227274
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.25309312
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18578606
21* ELK1_19687146_ChIP-ChIP_HELA_Human2.11707166
22TTF2_22483619_ChIP-Seq_HELA_Human1.99807833
23* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95235922
24* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93948911
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92523656
26ELK1_22589737_ChIP-Seq_MCF10A_Human1.89528532
27VDR_23849224_ChIP-Seq_CD4+_Human1.88528519
28* DCP1A_22483619_ChIP-Seq_HELA_Human1.86205569
29* XRN2_22483619_ChIP-Seq_HELA_Human1.82361411
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.80596358
31* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.73297819
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72032155
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71525444
34FUS_26573619_Chip-Seq_HEK293_Human1.68360814
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61004237
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60429605
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59020335
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.57143062
39TAF15_26573619_Chip-Seq_HEK293_Human1.55343646
40IRF1_19129219_ChIP-ChIP_H3396_Human1.53735772
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53672362
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53016760
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.50624946
44MYC_18940864_ChIP-ChIP_HL60_Human1.49533427
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48321126
46FOXP3_21729870_ChIP-Seq_TREG_Human1.47754332
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.44286640
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40796235
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35104437
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33505782
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33138413
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.33103258
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.32710391
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30867927
55IGF1R_20145208_ChIP-Seq_DFB_Human1.28429169
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25883970
57ZNF274_21170338_ChIP-Seq_K562_Hela1.22918275
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22172821
59RNF2_27304074_Chip-Seq_NSC_Mouse1.21245662
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20091208
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.19399496
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18094318
63* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16267452
64* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16056039
65AR_21909140_ChIP-Seq_LNCAP_Human1.14979359
66ER_23166858_ChIP-Seq_MCF-7_Human1.13746337
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13303049
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13148650
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09676085
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09615194
71GBX2_23144817_ChIP-Seq_PC3_Human1.08335303
72EWS_26573619_Chip-Seq_HEK293_Human1.07695526
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07649674
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05722775
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05347821
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04737651
77* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04646098
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.03678899
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03199649
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01813144
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01300218
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01093563
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00935565
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00928651
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99920577
86* E2F1_21310950_ChIP-Seq_MCF-7_Human0.99263819
87SOX2_16153702_ChIP-ChIP_HESCs_Human0.98366928
88* GABP_19822575_ChIP-Seq_HepG2_Human0.97586737
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96311412
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95845550
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95110474
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94807269
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94657611
94FOXM1_23109430_ChIP-Seq_U2OS_Human0.93676840
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.93354158
96HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92981363
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92786955
98* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90556402
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89726142
100CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88581462
101SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88422445
102* P300_19829295_ChIP-Seq_ESCs_Human0.88042297
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87212686
104* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86906280
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86453727
106ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86397728
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85327431
108PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83656590
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83654055
110* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81607662
111TP53_22573176_ChIP-Seq_HFKS_Human0.81332188
112WT1_19549856_ChIP-ChIP_CCG9911_Human0.80935079
113SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.80902282
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80641144
115E2F4_17652178_ChIP-ChIP_JURKAT_Human0.79339082
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78163011
117POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.78074061
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77656520
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77360593
120ERG_20517297_ChIP-Seq_VCAP_Human0.76973219
121KDM5A_27292631_Chip-Seq_BREAST_Human0.76589781
122* ELF5_23300383_ChIP-Seq_T47D_Human0.76133018
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75218600
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74877691
125SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73510298
126E2F7_22180533_ChIP-Seq_HELA_Human0.72697104
127ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.72284132
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72036684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.10869196
2MP0003136_yellow_coat_color3.67860698
3MP0001529_abnormal_vocalization3.23255127
4MP0003880_abnormal_central_pattern3.10309793
5MP0003806_abnormal_nucleotide_metabolis2.89722045
6MP0001905_abnormal_dopamine_level2.59791639
7MP0006276_abnormal_autonomic_nervous2.55349892
8MP0001188_hyperpigmentation2.45028693
9MP0005409_darkened_coat_color2.41920200
10MP0005423_abnormal_somatic_nervous2.39630185
11MP0002102_abnormal_ear_morphology2.32486141
12MP0008058_abnormal_DNA_repair2.24925249
13MP0002938_white_spotting2.21955513
14MP0004381_abnormal_hair_follicle2.20284694
15MP0002638_abnormal_pupillary_reflex2.19525221
16MP0005379_endocrine/exocrine_gland_phen2.16570883
17MP0002163_abnormal_gland_morphology2.13742676
18MP0001986_abnormal_taste_sensitivity1.94413460
19MP0006072_abnormal_retinal_apoptosis1.93083859
20MP0003693_abnormal_embryo_hatching1.77205771
21MP0000566_synostosis1.69110166
22MP0000049_abnormal_middle_ear1.68184180
23MP0006292_abnormal_olfactory_placode1.65440250
24MP0004142_abnormal_muscle_tone1.62842070
25MP0001293_anophthalmia1.62828896
26MP0000372_irregular_coat_pigmentation1.59278284
27MP0002277_abnormal_respiratory_mucosa1.55688693
28MP0003938_abnormal_ear_development1.55360700
29MP0000631_abnormal_neuroendocrine_gland1.50038687
30MP0000778_abnormal_nervous_system1.49582576
31MP0003123_paternal_imprinting1.47785298
32MP0002751_abnormal_autonomic_nervous1.46888639
33MP0004742_abnormal_vestibular_system1.46719675
34MP0010386_abnormal_urinary_bladder1.46149820
35MP0003077_abnormal_cell_cycle1.45194988
36MP0002234_abnormal_pharynx_morphology1.42559844
37MP0008932_abnormal_embryonic_tissue1.41300806
38MP0008789_abnormal_olfactory_epithelium1.40754518
39MP0002697_abnormal_eye_size1.40400154
40MP0005645_abnormal_hypothalamus_physiol1.40184996
41MP0000579_abnormal_nail_morphology1.39092562
42MP0001346_abnormal_lacrimal_gland1.37587134
43MP0002734_abnormal_mechanical_nocicepti1.37499694
44MP0009697_abnormal_copulation1.36059843
45MP0003011_delayed_dark_adaptation1.33733102
46MP0001485_abnormal_pinna_reflex1.31729337
47MP0009250_abnormal_appendicular_skeleto1.31632717
48MP0001984_abnormal_olfaction1.31429002
49MP0004133_heterotaxia1.29782827
50MP0000026_abnormal_inner_ear1.29738577
51MP0003315_abnormal_perineum_morphology1.29671120
52MP0005171_absent_coat_pigmentation1.29531498
53MP0002822_catalepsy1.28318589
54MP0003718_maternal_effect1.23449771
55MP0003122_maternal_imprinting1.19935479
56MP0010094_abnormal_chromosome_stability1.19305507
57MP0005408_hypopigmentation1.18814754
58MP0000762_abnormal_tongue_morphology1.18013569
59MP0004885_abnormal_endolymph1.17452533
60MP0006036_abnormal_mitochondrial_physio1.16262575
61MP0002272_abnormal_nervous_system1.15625338
62MP0003724_increased_susceptibility_to1.14692859
63MP0003121_genomic_imprinting1.13287992
64MP0000462_abnormal_digestive_system1.11417352
65MP0002177_abnormal_outer_ear1.11313932
66MP0002282_abnormal_trachea_morphology1.10804480
67MP0003937_abnormal_limbs/digits/tail_de1.08918876
68MP0001968_abnormal_touch/_nociception1.08388522
69MP0001440_abnormal_grooming_behavior1.08289397
70MP0005551_abnormal_eye_electrophysiolog1.07813849
71MP0001486_abnormal_startle_reflex1.04740815
72MP0009384_cardiac_valve_regurgitation1.04373093
73MP0000647_abnormal_sebaceous_gland1.04126848
74MP0003385_abnormal_body_wall1.03924599
75MP0005253_abnormal_eye_physiology1.03476666
76MP0002572_abnormal_emotion/affect_behav1.03181444
77MP0003890_abnormal_embryonic-extraembry1.02881097
78MP0002184_abnormal_innervation1.02411080
79MP0002752_abnormal_somatic_nervous1.02180173
80MP0003941_abnormal_skin_development1.02151708
81MP0000613_abnormal_salivary_gland1.01857412
82MP0001879_abnormal_lymphatic_vessel1.01822522
83MP0005197_abnormal_uvea_morphology0.99765114
84MP0001970_abnormal_pain_threshold0.99412393
85MP0005174_abnormal_tail_pigmentation0.98291099
86MP0001727_abnormal_embryo_implantation0.97367409
87MP0004270_analgesia0.96934787
88MP0002735_abnormal_chemical_nociception0.95095274
89MP0000920_abnormal_myelination0.94599571
90MP0005391_vision/eye_phenotype0.94128671
91MP0002233_abnormal_nose_morphology0.92247714
92MP0002736_abnormal_nociception_after0.90878228
93MP0002160_abnormal_reproductive_system0.90332696
94MP0005257_abnormal_intraocular_pressure0.89491484
95MP0008007_abnormal_cellular_replicative0.87395107
96MP0008775_abnormal_heart_ventricle0.87261856
97MP0002557_abnormal_social/conspecific_i0.86845316
98MP0003786_premature_aging0.86491995
99MP0002132_abnormal_respiratory_system0.85556079
100MP0009745_abnormal_behavioral_response0.85214801
101MP0005499_abnormal_olfactory_system0.84417601
102MP0005394_taste/olfaction_phenotype0.84417601
103MP0001963_abnormal_hearing_physiology0.84348875
104MP0003111_abnormal_nucleus_morphology0.84333663
105MP0000358_abnormal_cell_content/0.82842108
106MP0002064_seizures0.82767950
107MP0002210_abnormal_sex_determination0.80381586
108MP0000538_abnormal_urinary_bladder0.79526700
109MP0001881_abnormal_mammary_gland0.78537889
110MP0002067_abnormal_sensory_capabilities0.78099693
111MP0005084_abnormal_gallbladder_morpholo0.78030129
112MP0004957_abnormal_blastocyst_morpholog0.77101595
113MP0005195_abnormal_posterior_eye0.77023359
114MP0008875_abnormal_xenobiotic_pharmacok0.77011463
115MP0008004_abnormal_stomach_pH0.76436643
116MP0003755_abnormal_palate_morphology0.75911581
117MP0002653_abnormal_ependyma_morphology0.75388426
118MP0001299_abnormal_eye_distance/0.75125858
119MP0003567_abnormal_fetal_cardiomyocyte0.74860682
120MP0002693_abnormal_pancreas_physiology0.74106138
121MP0002733_abnormal_thermal_nociception0.74006962
122MP0010030_abnormal_orbit_morphology0.73816761
123MP0008995_early_reproductive_senescence0.73280750
124MP0001286_abnormal_eye_development0.73255010
125MP0002295_abnormal_pulmonary_circulatio0.71865934
126MP0001542_abnormal_bone_strength0.70707246
127MP0002882_abnormal_neuron_morphology0.70651595
128MP0003283_abnormal_digestive_organ0.69236830
129MP0002090_abnormal_vision0.67835367
130MP0005332_abnormal_amino_acid0.67303561
131MP0005389_reproductive_system_phenotype0.67242525
132MP0001340_abnormal_eyelid_morphology0.67085955
133MP0001664_abnormal_digestion0.66662554
134MP0001764_abnormal_homeostasis0.66413133
135MP0002111_abnormal_tail_morphology0.66300539
136MP0002837_dystrophic_cardiac_calcinosis0.66295126
137MP0003186_abnormal_redox_activity0.65938782
138MP0000015_abnormal_ear_pigmentation0.65647235
139MP0002095_abnormal_skin_pigmentation0.65220670
140MP0002249_abnormal_larynx_morphology0.64020553
141MP0006035_abnormal_mitochondrial_morpho0.63220969

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.21900711
2Mitochondrial inheritance (HP:0001427)5.50484078
3Abnormality of cells of the erythroid lineage (HP:0012130)5.33951817
4Increased hepatocellular lipid droplets (HP:0006565)5.33640252
5Abnormal mitochondria in muscle tissue (HP:0008316)5.33223665
6Reticulocytopenia (HP:0001896)5.28370005
7Progressive macrocephaly (HP:0004481)5.24471816
8Renal Fanconi syndrome (HP:0001994)4.91141201
9Acute encephalopathy (HP:0006846)4.88985175
10Abnormal number of erythroid precursors (HP:0012131)4.60817657
11Lipid accumulation in hepatocytes (HP:0006561)4.59535112
12Macrocytic anemia (HP:0001972)4.51970576
13Increased CSF lactate (HP:0002490)4.32576892
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.21951963
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.20148502
16Hepatocellular necrosis (HP:0001404)4.19283700
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.02131254
18Parakeratosis (HP:0001036)3.91670281
19Pallor (HP:0000980)3.88979042
20Exertional dyspnea (HP:0002875)3.78469294
213-Methylglutaconic aciduria (HP:0003535)3.63214484
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.55800071
23Optic disc pallor (HP:0000543)3.49961293
24Increased intramyocellular lipid droplets (HP:0012240)3.47997131
25Hepatic necrosis (HP:0002605)3.41431424
26Abnormality of renal resorption (HP:0011038)3.21081822
27Concave nail (HP:0001598)3.18729447
28Exercise intolerance (HP:0003546)3.17536699
29Abnormal hemoglobin (HP:0011902)3.12494989
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07345007
31Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07345007
32Cerebral edema (HP:0002181)3.06476575
33Leukodystrophy (HP:0002415)3.06096445
34Respiratory failure (HP:0002878)2.93957389
35Abnormality of glycolysis (HP:0004366)2.81331860
36Increased serum pyruvate (HP:0003542)2.81331860
37Congenital ichthyosiform erythroderma (HP:0007431)2.80751227
38Hyperphosphaturia (HP:0003109)2.77050901
39Respiratory difficulties (HP:0002880)2.73605526
40Septo-optic dysplasia (HP:0100842)2.69822354
41Oral leukoplakia (HP:0002745)2.69191347
42Increased muscle lipid content (HP:0009058)2.66576794
43Aplasia/hypoplasia of the uterus (HP:0008684)2.58546945
44Increased serum lactate (HP:0002151)2.55812530
45Abnormality of the axillary hair (HP:0100134)2.51035881
46Abnormality of secondary sexual hair (HP:0009888)2.51035881
47Congenital, generalized hypertrichosis (HP:0004540)2.49799120
48Abnormal pupillary function (HP:0007686)2.42569334
49Lactic acidosis (HP:0003128)2.40499066
50Aplastic anemia (HP:0001915)2.38534714
51Hypothermia (HP:0002045)2.32147464
52Abnormal urine phosphate concentration (HP:0012599)2.31998952
53Molar tooth sign on MRI (HP:0002419)2.30961492
54Abnormality of midbrain morphology (HP:0002418)2.30961492
55Methylmalonic acidemia (HP:0002912)2.30273539
56Amniotic constriction ring (HP:0009775)2.29266110
57Abnormality of placental membranes (HP:0011409)2.29266110
58Lethargy (HP:0001254)2.26148594
59Pancreatic fibrosis (HP:0100732)2.24514284
60Generalized aminoaciduria (HP:0002909)2.22223242
61Abnormal ciliary motility (HP:0012262)2.17018938
62Medial flaring of the eyebrow (HP:0010747)2.13812852
63Glycosuria (HP:0003076)2.09285223
64Abnormality of urine glucose concentration (HP:0011016)2.09285223
65Stenosis of the external auditory canal (HP:0000402)2.08817383
66Absent septum pellucidum (HP:0001331)2.08392076
67X-linked dominant inheritance (HP:0001423)2.06283010
68Abnormal respiratory epithelium morphology (HP:0012253)2.04633881
69Abnormal respiratory motile cilium morphology (HP:0005938)2.04633881
70Abnormality of methionine metabolism (HP:0010901)1.99641133
71Breast hypoplasia (HP:0003187)1.99274668
72Colon cancer (HP:0003003)1.98988317
73Renal tubular dysfunction (HP:0000124)1.98598216
74Degeneration of anterior horn cells (HP:0002398)1.97849039
75Abnormality of the anterior horn cell (HP:0006802)1.97849039
76Reduced antithrombin III activity (HP:0001976)1.95908401
77Depressed nasal ridge (HP:0000457)1.93780575
78Methylmalonic aciduria (HP:0012120)1.91961637
79Type I transferrin isoform profile (HP:0003642)1.91657249
80Hyperglycinemia (HP:0002154)1.86118028
81Nephronophthisis (HP:0000090)1.85666193
82Hypoplastic pelvis (HP:0008839)1.84389255
83Sensory axonal neuropathy (HP:0003390)1.83959978
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83871357
85Abnormal protein N-linked glycosylation (HP:0012347)1.83871357
86Abnormal protein glycosylation (HP:0012346)1.83871357
87Abnormal glycosylation (HP:0012345)1.83871357
88Triphalangeal thumb (HP:0001199)1.83723650
89Cerebral hypomyelination (HP:0006808)1.82872050
90Microvesicular hepatic steatosis (HP:0001414)1.82430841
91Limb dystonia (HP:0002451)1.80311392
92Abnormality of cochlea (HP:0000375)1.78851618
93Rib fusion (HP:0000902)1.78110753
94Hypoplasia of the uterus (HP:0000013)1.78068920
95Abnormal respiratory motile cilium physiology (HP:0012261)1.76725014
96Pancytopenia (HP:0001876)1.74983836
97Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74971168
98Short tibia (HP:0005736)1.74389611
99Sparse eyelashes (HP:0000653)1.74372658
100Gait imbalance (HP:0002141)1.73567942
101Secondary amenorrhea (HP:0000869)1.72349189
102Bilateral microphthalmos (HP:0007633)1.72293751
103Hypoplasia of the pons (HP:0012110)1.70889086
104Abnormality of serum amino acid levels (HP:0003112)1.70888316
105Congenital sensorineural hearing impairment (HP:0008527)1.69874676
106Abnormality of the pons (HP:0007361)1.69292921
107Partial duplication of the phalanx of hand (HP:0009999)1.68880700
108Horseshoe kidney (HP:0000085)1.68445945
109Adrenal hypoplasia (HP:0000835)1.67658604
110True hermaphroditism (HP:0010459)1.67258951
111Congenital primary aphakia (HP:0007707)1.65860516
112Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64835964
113Partial duplication of thumb phalanx (HP:0009944)1.64333956
114Anophthalmia (HP:0000528)1.64297425
115Myelomeningocele (HP:0002475)1.63445478
116Absent thumb (HP:0009777)1.62716797
117Nasolacrimal duct obstruction (HP:0000579)1.62632518
118Vaginal atresia (HP:0000148)1.62346141
119Megaloblastic anemia (HP:0001889)1.61760447
120Absent/shortened dynein arms (HP:0200106)1.61598121
121Dynein arm defect of respiratory motile cilia (HP:0012255)1.61598121
122Emotional lability (HP:0000712)1.61575315
123Morphological abnormality of the inner ear (HP:0011390)1.61547939
124Nephrogenic diabetes insipidus (HP:0009806)1.61486593
125Testicular atrophy (HP:0000029)1.60366066
126Pancreatic cysts (HP:0001737)1.59772208
127Bifid tongue (HP:0010297)1.59419312
128Abnormality of the septum pellucidum (HP:0007375)1.58901978
129Sclerocornea (HP:0000647)1.58757405
130Anencephaly (HP:0002323)1.58423584
131Genital tract atresia (HP:0001827)1.57047647
132Aplasia/Hypoplasia involving the musculature (HP:0001460)1.56157356
133Abnormal sex determination (HP:0012244)1.55497452
134Sex reversal (HP:0012245)1.55497452
135CNS demyelination (HP:0007305)1.53413223
136Aplasia of the musculature (HP:0100854)1.50718996
137Patchy hypopigmentation of hair (HP:0011365)1.49204674
138Blindness (HP:0000618)1.49091857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.97538589
2TLK14.48632615
3STK163.43785774
4NME23.19471069
5PBK3.16208512
6CASK2.82011577
7NME12.79496840
8BUB12.46112018
9STK392.33326544
10ZAK2.33275924
11MST42.31565268
12SRPK12.25935469
13CDC72.23761958
14VRK12.17647983
15NEK12.07633478
16PNCK1.96025342
17EIF2AK11.95123088
18TNIK1.93338154
19BMPR1B1.84903407
20DYRK21.77059830
21MKNK21.61559691
22GRK71.58370663
23IRAK21.55050779
24UHMK11.51670345
25WNK41.50858911
26LIMK11.50510097
27MKNK11.49281380
28PLK31.46439199
29CDK191.45864590
30BCR1.44329396
31TESK21.42070156
32EIF2AK31.41247449
33OXSR11.40102154
34TAF11.38582970
35MAPK151.34733184
36BCKDK1.30279669
37WEE11.27444401
38BRSK21.26549358
39IRAK31.19797359
40NUAK11.18709318
41MAPK131.18192044
42ADRBK21.16019151
43PIM21.11310239
44MARK11.11245729
45DYRK31.09063651
46CDK81.05236395
47IRAK11.04694222
48MAP4K21.04266957
49MAPKAPK51.04134831
50PKN11.02851075
51TRIM281.02759120
52TTK1.02102479
53CAMK2B0.97275488
54FES0.95257814
55IRAK40.94955156
56BRAF0.89939487
57BLK0.89158511
58MAP3K40.89123646
59CSNK1G30.88841625
60MUSK0.87588207
61MAP3K120.87231886
62ADRBK10.86211790
63AURKA0.82186418
64EIF2AK20.81691292
65WNK30.79906760
66FGR0.78597956
67ABL20.77010415
68MYLK0.76257588
69CHEK20.75241877
70RPS6KA50.74726621
71ERBB30.73820213
72BMPR20.73534427
73MAP2K70.70630760
74RPS6KA40.70535169
75YES10.70337022
76PAK40.69197987
77TSSK60.68179714
78PIK3CG0.68031104
79NEK20.65256460
80DAPK30.64371701
81PASK0.63677099
82STK38L0.63390595
83CAMK2D0.62954922
84CSNK2A20.61387738
85CSNK2A10.61045514
86BRSK10.60995383
87CAMK2A0.59612556
88ARAF0.59482668
89GRK50.59476277
90DYRK1A0.58367862
91PLK20.58292533
92CSNK1G10.57717027
93NEK60.57426672
94PHKG20.56088044
95PHKG10.56088044
96MAP2K20.53343398
97CDK140.52274657
98ROCK20.50442509
99PRKCE0.50006638
100EPHB20.49653554
101PDK20.49385493
102CAMK2G0.47291878
103PLK40.46598389
104PRKCG0.46412750
105PRKCI0.46100144
106CDK30.45501213
107CSNK1G20.43484861
108FGFR10.42362446
109CSNK1A1L0.42030792
110CDK11A0.41619679
111STK240.41519715
112CSNK1E0.41224864
113NTRK20.41193003
114KDR0.40507541
115ILK0.40340133
116PRKACA0.40263444
117GRK10.39987253
118LRRK20.39139065
119ATR0.38208682
120INSRR0.38008611
121CDK150.37320422
122NTRK10.37000073
123CDK180.36241110
124MET0.35149668
125AURKB0.35033457
126FLT30.34292586
127TESK10.34177143
128TGFBR10.32702484
129OBSCN0.32307152
130ERBB40.32150010
131LYN0.31724777
132STK40.31314783
133CLK10.31031515
134CDK70.30727142
135PLK10.30683241

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.50414559
2Oxidative phosphorylation_Homo sapiens_hsa001905.22713330
3Parkinsons disease_Homo sapiens_hsa050124.31998323
4* Protein export_Homo sapiens_hsa030603.84768048
5Proteasome_Homo sapiens_hsa030503.62249887
6RNA polymerase_Homo sapiens_hsa030203.38038157
7Alzheimers disease_Homo sapiens_hsa050103.32441399
8Huntingtons disease_Homo sapiens_hsa050163.28049181
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.69632296
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25371238
11Spliceosome_Homo sapiens_hsa030401.93777946
12Cardiac muscle contraction_Homo sapiens_hsa042601.81281603
13Pyrimidine metabolism_Homo sapiens_hsa002401.77832509
14Basal transcription factors_Homo sapiens_hsa030221.49737009
15Homologous recombination_Homo sapiens_hsa034401.43798696
16Nucleotide excision repair_Homo sapiens_hsa034201.40236111
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35745746
18Mismatch repair_Homo sapiens_hsa034301.34244723
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.26911069
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23630200
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22832149
22DNA replication_Homo sapiens_hsa030301.16968212
23Collecting duct acid secretion_Homo sapiens_hsa049661.12736782
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12200215
25Steroid biosynthesis_Homo sapiens_hsa001001.11382424
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09750789
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09432742
28Fatty acid elongation_Homo sapiens_hsa000621.08740356
29Sulfur metabolism_Homo sapiens_hsa009201.05698010
30Sphingolipid metabolism_Homo sapiens_hsa006001.03618886
31Ether lipid metabolism_Homo sapiens_hsa005651.03426662
32Phototransduction_Homo sapiens_hsa047440.98518770
33Purine metabolism_Homo sapiens_hsa002300.97894159
34Propanoate metabolism_Homo sapiens_hsa006400.92261519
35Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92260489
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91246420
37Fanconi anemia pathway_Homo sapiens_hsa034600.88177397
38Pyruvate metabolism_Homo sapiens_hsa006200.88158687
39Serotonergic synapse_Homo sapiens_hsa047260.88141011
40RNA degradation_Homo sapiens_hsa030180.87892116
41Arachidonic acid metabolism_Homo sapiens_hsa005900.86097281
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83298874
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81207054
44* Vibrio cholerae infection_Homo sapiens_hsa051100.79562805
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.78686293
46RNA transport_Homo sapiens_hsa030130.74785110
47Linoleic acid metabolism_Homo sapiens_hsa005910.72250794
48Nicotine addiction_Homo sapiens_hsa050330.72187756
49Chemical carcinogenesis_Homo sapiens_hsa052040.72182763
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.70447207
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69650078
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68765777
53Glutathione metabolism_Homo sapiens_hsa004800.67559857
54Metabolic pathways_Homo sapiens_hsa011000.65233609
55Non-homologous end-joining_Homo sapiens_hsa034500.63990145
56Rheumatoid arthritis_Homo sapiens_hsa053230.62493918
57Systemic lupus erythematosus_Homo sapiens_hsa053220.61596056
58Folate biosynthesis_Homo sapiens_hsa007900.60915425
59Peroxisome_Homo sapiens_hsa041460.60096466
60Asthma_Homo sapiens_hsa053100.59018628
61Graft-versus-host disease_Homo sapiens_hsa053320.58892585
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58846611
63Autoimmune thyroid disease_Homo sapiens_hsa053200.57745601
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57678215
65Sulfur relay system_Homo sapiens_hsa041220.57419842
66Alcoholism_Homo sapiens_hsa050340.56391522
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56110502
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55511959
69Tyrosine metabolism_Homo sapiens_hsa003500.53579444
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.52188465
71Selenocompound metabolism_Homo sapiens_hsa004500.48962765
72Base excision repair_Homo sapiens_hsa034100.46388127
73Nitrogen metabolism_Homo sapiens_hsa009100.46066287
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45437620
75Allograft rejection_Homo sapiens_hsa053300.45270510
76Axon guidance_Homo sapiens_hsa043600.44301522
77Epstein-Barr virus infection_Homo sapiens_hsa051690.43772386
78Butanoate metabolism_Homo sapiens_hsa006500.42765946
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42525824
80Mineral absorption_Homo sapiens_hsa049780.40055500
81Taste transduction_Homo sapiens_hsa047420.39833088
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38688998
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37268135
84Carbon metabolism_Homo sapiens_hsa012000.36933898
85Biosynthesis of amino acids_Homo sapiens_hsa012300.36690700
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36638304
87Retinol metabolism_Homo sapiens_hsa008300.36532032
88Cocaine addiction_Homo sapiens_hsa050300.36184610
89One carbon pool by folate_Homo sapiens_hsa006700.35643050
90Type I diabetes mellitus_Homo sapiens_hsa049400.35448274
91Histidine metabolism_Homo sapiens_hsa003400.35344372
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.34921935
93Long-term depression_Homo sapiens_hsa047300.34692713
94Caffeine metabolism_Homo sapiens_hsa002320.34521826
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32176377
96Tryptophan metabolism_Homo sapiens_hsa003800.32042544
97Phenylalanine metabolism_Homo sapiens_hsa003600.32021802
98p53 signaling pathway_Homo sapiens_hsa041150.30383704
99Other glycan degradation_Homo sapiens_hsa005110.29198970
100Oocyte meiosis_Homo sapiens_hsa041140.29160574
101* Phagosome_Homo sapiens_hsa041450.29029710
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27878049
103Hedgehog signaling pathway_Homo sapiens_hsa043400.27551418
104GABAergic synapse_Homo sapiens_hsa047270.26980119
105Arginine and proline metabolism_Homo sapiens_hsa003300.26235380
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26137759
107Vitamin digestion and absorption_Homo sapiens_hsa049770.25788398
108Regulation of autophagy_Homo sapiens_hsa041400.25189877
109N-Glycan biosynthesis_Homo sapiens_hsa005100.24359207
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22276445
111mRNA surveillance pathway_Homo sapiens_hsa030150.22206082
112Wnt signaling pathway_Homo sapiens_hsa043100.21873119
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21470797
114Starch and sucrose metabolism_Homo sapiens_hsa005000.20333877
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19902073
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19490175
117Fructose and mannose metabolism_Homo sapiens_hsa000510.19470177
118Basal cell carcinoma_Homo sapiens_hsa052170.19018573
119Cell cycle_Homo sapiens_hsa041100.18847884
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17698825
121* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17122800
122TGF-beta signaling pathway_Homo sapiens_hsa043500.16494825
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.16387241
124Glutamatergic synapse_Homo sapiens_hsa047240.16206810
125African trypanosomiasis_Homo sapiens_hsa051430.16124181
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14745946
127Melanogenesis_Homo sapiens_hsa049160.13747887
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13461081
129Dopaminergic synapse_Homo sapiens_hsa047280.13290688
130Morphine addiction_Homo sapiens_hsa050320.12964571
131Amphetamine addiction_Homo sapiens_hsa050310.12197988
132Malaria_Homo sapiens_hsa051440.10590607
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10465070
134Galactose metabolism_Homo sapiens_hsa000520.09948046

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