SEC62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.19313620
2central nervous system myelination (GO:0022010)7.19313620
3fatty acid elongation (GO:0030497)5.40321932
4cellular potassium ion homeostasis (GO:0030007)4.57841887
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.34592572
6long-chain fatty acid biosynthetic process (GO:0042759)4.25145487
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.15758884
8glutamate secretion (GO:0014047)4.13153479
9myelination (GO:0042552)4.10622315
10axon ensheathment (GO:0008366)4.08212381
11ensheathment of neurons (GO:0007272)4.08212381
12negative regulation of neurotransmitter transport (GO:0051589)3.98440449
13presynaptic membrane assembly (GO:0097105)3.98033982
14neuron cell-cell adhesion (GO:0007158)3.94840042
15presynaptic membrane organization (GO:0097090)3.86596656
16synaptic vesicle maturation (GO:0016188)3.83449312
17potassium ion import (GO:0010107)3.70445125
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60992154
19negative regulation of neurotransmitter secretion (GO:0046929)3.57220347
20postsynaptic membrane organization (GO:0001941)3.50509082
21neuron remodeling (GO:0016322)3.45102105
22ATP synthesis coupled proton transport (GO:0015986)3.36072012
23energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36072012
24neurotransmitter secretion (GO:0007269)3.35939869
25response to methylmercury (GO:0051597)3.35598759
26respiratory electron transport chain (GO:0022904)3.33748472
27potassium ion homeostasis (GO:0055075)3.33481552
28cellular sodium ion homeostasis (GO:0006883)3.33357306
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.31534233
30auditory behavior (GO:0031223)3.30798409
31electron transport chain (GO:0022900)3.25094499
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.24329904
33dopamine biosynthetic process (GO:0042416)3.19942050
34neuronal action potential propagation (GO:0019227)3.18966999
35regulation of synapse structural plasticity (GO:0051823)3.17188341
36detection of calcium ion (GO:0005513)3.12682246
37synaptic transmission, glutamatergic (GO:0035249)3.07855134
38cholesterol biosynthetic process (GO:0006695)3.07338072
39cerebellar Purkinje cell layer development (GO:0021680)3.07245185
40apical protein localization (GO:0045176)3.06297833
41regulation of oxidative phosphorylation (GO:0002082)3.03929439
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.03200594
43oligodendrocyte differentiation (GO:0048709)3.02521008
44myelin maintenance (GO:0043217)3.02238942
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.01745781
46mechanosensory behavior (GO:0007638)3.01579510
47transmission of nerve impulse (GO:0019226)3.01512755
48substantia nigra development (GO:0021762)3.01362549
49sodium ion export (GO:0071436)2.97079564
50glycerophospholipid catabolic process (GO:0046475)2.96031140
51neuron recognition (GO:0008038)2.94864075
52regulation of synaptic vesicle exocytosis (GO:2000300)2.94017079
53neurotransmitter uptake (GO:0001504)2.90549564
54regulation of dopamine metabolic process (GO:0042053)2.88395195
55regulation of catecholamine metabolic process (GO:0042069)2.88395195
56regulation of excitatory postsynaptic membrane potential (GO:0060079)2.86701602
57short-term memory (GO:0007614)2.86613200
58asymmetric protein localization (GO:0008105)2.82817531
59regulation of neuronal synaptic plasticity (GO:0048168)2.82734836
60mating behavior (GO:0007617)2.82350056
61neurofilament cytoskeleton organization (GO:0060052)2.80256254
62neurotransmitter transport (GO:0006836)2.79253048
63regulation of long-term neuronal synaptic plasticity (GO:0048169)2.79058466
64negative regulation of protein localization to cell surface (GO:2000009)2.79032140
65cerebellar Purkinje cell differentiation (GO:0021702)2.78905722
66response to auditory stimulus (GO:0010996)2.78760364
67regulation of postsynaptic membrane potential (GO:0060078)2.78581457
68exploration behavior (GO:0035640)2.78071261
69neurotransmitter catabolic process (GO:0042135)2.77373420
70behavioral response to nicotine (GO:0035095)2.77186154
71eye photoreceptor cell differentiation (GO:0001754)2.76857681
72photoreceptor cell differentiation (GO:0046530)2.76857681
73long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.76781351
74regulation of synaptic vesicle transport (GO:1902803)2.76308802
75startle response (GO:0001964)2.75724945
76positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.73926489
77regulation of neurotransmitter levels (GO:0001505)2.73218832
78long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.72501216
79negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71030616
80regulation of glutamate receptor signaling pathway (GO:1900449)2.70411950
81synaptic vesicle exocytosis (GO:0016079)2.69186752
82response to redox state (GO:0051775)2.68216846
83L-amino acid import (GO:0043092)2.67988911
84membrane hyperpolarization (GO:0060081)2.67696397
85sterol biosynthetic process (GO:0016126)2.66992522
86positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.65887148
87membrane depolarization (GO:0051899)2.65697500
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65164908
89membrane repolarization (GO:0086009)2.64081227
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.63822220
91urinary tract smooth muscle contraction (GO:0014848)2.63583603
92regulation of collateral sprouting (GO:0048670)2.61989893
93positive regulation of potassium ion transmembrane transport (GO:1901381)2.61569916
94serotonin metabolic process (GO:0042428)2.61553148
95response to histamine (GO:0034776)2.61258162
96establishment of mitochondrion localization (GO:0051654)2.60295895
97cell differentiation in hindbrain (GO:0021533)2.59212366
98negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.58595288
99locomotory exploration behavior (GO:0035641)2.57903910
100import into cell (GO:0098657)2.56689540
101gamma-aminobutyric acid transport (GO:0015812)2.54814451
102synapse assembly (GO:0007416)2.54738182
103behavioral fear response (GO:0001662)2.54580949
104behavioral defense response (GO:0002209)2.54580949
105neurotransmitter-gated ion channel clustering (GO:0072578)2.54206121
106pyrimidine nucleobase catabolic process (GO:0006208)2.54203466
107positive regulation of dendritic spine development (GO:0060999)2.53968557
108very long-chain fatty acid metabolic process (GO:0000038)2.53742348
109vocalization behavior (GO:0071625)2.53599205
110positive regulation of synapse assembly (GO:0051965)2.53418591
111regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51722688
112fatty-acyl-CoA metabolic process (GO:0035337)2.51159934
113L-phenylalanine catabolic process (GO:0006559)2.50224881
114erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.50224881
115protein neddylation (GO:0045116)2.49507177
116membrane depolarization during action potential (GO:0086010)2.49406721
117fear response (GO:0042596)2.48744889
118amyloid precursor protein metabolic process (GO:0042982)2.47347658
119regulation of dopamine secretion (GO:0014059)2.47029396
120neuronal ion channel clustering (GO:0045161)2.45782324
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45548318
122dendrite morphogenesis (GO:0048813)2.44872818
123fatty-acyl-CoA biosynthetic process (GO:0046949)2.44544453
124response to dietary excess (GO:0002021)2.43978935
125glutamate receptor signaling pathway (GO:0007215)2.42577385
126adult walking behavior (GO:0007628)2.41946433
127cerebellar granule cell differentiation (GO:0021707)2.40280073
128ionotropic glutamate receptor signaling pathway (GO:0035235)2.38989277
129behavioral response to cocaine (GO:0048148)2.37915301
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.37563098
131regulation of glutamate secretion (GO:0014048)2.37219436
132limb bud formation (GO:0060174)2.36933451
133protein localization to synapse (GO:0035418)2.36656561
134chaperone-mediated protein transport (GO:0072321)2.36355703
135axonal fasciculation (GO:0007413)2.36163235
136positive regulation of action potential (GO:0045760)2.35800566
137membrane assembly (GO:0071709)2.34982035
138creatine metabolic process (GO:0006600)2.34597013
139negative regulation of synaptic transmission (GO:0050805)2.34206054
140isoprenoid biosynthetic process (GO:0008299)2.33984682
141virion attachment to host cell (GO:0019062)2.33982619
142adhesion of symbiont to host cell (GO:0044650)2.33982619
143regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.33980474
144magnesium ion transport (GO:0015693)2.30554015
145neuron-neuron synaptic transmission (GO:0007270)2.30316799
146cellular response to epinephrine stimulus (GO:0071872)2.27862062
147calcium-mediated signaling using intracellular calcium source (GO:0035584)2.27266835
148positive regulation of cellular amine metabolic process (GO:0033240)2.27095743
149negative regulation of JUN kinase activity (GO:0043508)2.27024488
150nucleotide transmembrane transport (GO:1901679)2.24302541
151positive regulation of oligodendrocyte differentiation (GO:0048714)2.23503942
152astrocyte development (GO:0014002)2.23425029
153cerebral cortex radially oriented cell migration (GO:0021799)2.22564554
154iron coordination entity transport (GO:1901678)2.22271668
155amino acid import (GO:0043090)2.21415287
156dendritic spine morphogenesis (GO:0060997)2.21249055
157establishment of protein localization to mitochondrial membrane (GO:0090151)2.20666913
158energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.20239984
159ATP hydrolysis coupled proton transport (GO:0015991)2.20239984
160hydrogen ion transmembrane transport (GO:1902600)2.20008376
161positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.19728252
162regulation of short-term neuronal synaptic plasticity (GO:0048172)2.19695976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.40038057
2GBX2_23144817_ChIP-Seq_PC3_Human3.28475449
3TAF15_26573619_Chip-Seq_HEK293_Human2.76173684
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68539199
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63232660
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53663617
7SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30614861
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26163796
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19855187
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19855187
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17811143
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.17088990
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.16957665
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13697587
15SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.03740284
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02960191
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02312252
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01339632
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93307753
20VDR_22108803_ChIP-Seq_LS180_Human1.91695246
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85737880
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84287985
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82039191
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80685812
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.79534804
26AR_21572438_ChIP-Seq_LNCaP_Human1.79477298
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77812305
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.77088247
29* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68163008
30ER_23166858_ChIP-Seq_MCF-7_Human1.65396922
31P300_19829295_ChIP-Seq_ESCs_Human1.64427307
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63318798
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60717574
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.60383211
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.60261998
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59373152
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52358372
38FUS_26573619_Chip-Seq_HEK293_Human1.51873066
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51703399
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.50710101
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50269525
42REST_21632747_ChIP-Seq_MESCs_Mouse1.46532016
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44438813
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43572668
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42643044
46SMAD4_21799915_ChIP-Seq_A2780_Human1.42161844
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.36542270
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32896415
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32047702
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30462229
51CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29728064
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29585845
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28624463
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28624463
55P53_22387025_ChIP-Seq_ESCs_Mouse1.28371721
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.26736106
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.26322892
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25784807
59DROSHA_22980978_ChIP-Seq_HELA_Human1.23695933
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.21582699
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21462476
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20966184
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19952441
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19952441
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15179028
66RNF2_27304074_Chip-Seq_NSC_Mouse1.14952734
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13569924
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12764384
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11910059
70ZNF274_21170338_ChIP-Seq_K562_Hela1.11801514
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11572072
72TP53_18474530_ChIP-ChIP_U2OS_Human1.11395216
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11303486
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.10879716
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10872323
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10858168
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10805014
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.10311251
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09359337
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08916668
81* EWS_26573619_Chip-Seq_HEK293_Human1.08293283
82SOX2_18555785_Chip-Seq_ESCs_Mouse1.07900509
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07711775
84CBP_20019798_ChIP-Seq_JUKART_Human1.06981599
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06981599
86STAT3_23295773_ChIP-Seq_U87_Human1.06716265
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.06523840
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.06508787
89AR_25329375_ChIP-Seq_VCAP_Human1.06296060
90RARB_27405468_Chip-Seq_BRAIN_Mouse1.06276941
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.05816617
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05704223
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05317161
94IGF1R_20145208_ChIP-Seq_DFB_Human1.04795902
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04314397
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.03987289
97HTT_18923047_ChIP-ChIP_STHdh_Human1.02588012
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02409159
99RUNX2_22187159_ChIP-Seq_PCA_Human1.01727607
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01721480
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01209878
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00080119
103AHR_22903824_ChIP-Seq_MCF-7_Human0.99052872
104SOX2_21211035_ChIP-Seq_LN229_Gbm0.98397108
105ERG_21242973_ChIP-ChIP_JURKAT_Human0.98335568
106JUN_21703547_ChIP-Seq_K562_Human0.97311927
107P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95950378
108CMYC_18555785_Chip-Seq_ESCs_Mouse0.95927826
109TAL1_26923725_Chip-Seq_HPCs_Mouse0.94624895
110* TCF4_23295773_ChIP-Seq_U87_Human0.94542715
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93846731
112KDM2B_26808549_Chip-Seq_REH_Human0.93651630
113BCAT_22108803_ChIP-Seq_LS180_Human0.93348769
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92018705
115RING1B_27294783_Chip-Seq_ESCs_Mouse0.91911394
116IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91727914
117SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89499741
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89442541
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88642559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.42406253
2MP0000920_abnormal_myelination3.14945727
3MP0003787_abnormal_imprinting3.08067392
4MP0004270_analgesia3.01965513
5MP0002064_seizures2.52722332
6MP0004859_abnormal_synaptic_plasticity2.50712792
7MP0001905_abnormal_dopamine_level2.45765329
8MP0003635_abnormal_synaptic_transmissio2.45144257
9MP0002272_abnormal_nervous_system2.41740336
10MP0003329_amyloid_beta_deposits2.41090113
11MP0001529_abnormal_vocalization2.39902741
12MP0009745_abnormal_behavioral_response2.36596629
13MP0001486_abnormal_startle_reflex2.25502512
14MP0001440_abnormal_grooming_behavior2.22891677
15MP0009046_muscle_twitch2.20597387
16MP0005423_abnormal_somatic_nervous2.13637487
17MP0004147_increased_porphyrin_level2.12296821
18MP0003690_abnormal_glial_cell2.06597654
19MP0002638_abnormal_pupillary_reflex2.04640051
20MP0002734_abnormal_mechanical_nocicepti2.04125088
21MP0004142_abnormal_muscle_tone2.02537681
22MP0002572_abnormal_emotion/affect_behav1.97738292
23MP0004885_abnormal_endolymph1.96328096
24MP0004742_abnormal_vestibular_system1.95202780
25MP0002909_abnormal_adrenal_gland1.91636301
26MP0006276_abnormal_autonomic_nervous1.88591771
27MP0002063_abnormal_learning/memory/cond1.87560351
28MP0001968_abnormal_touch/_nociception1.86443435
29MP0004043_abnormal_pH_regulation1.85447826
30MP0003136_yellow_coat_color1.83242136
31MP0000778_abnormal_nervous_system1.82022991
32MP0001501_abnormal_sleep_pattern1.74382515
33MP0000569_abnormal_digit_pigmentation1.69939462
34MP0002736_abnormal_nociception_after1.68306239
35MP0003634_abnormal_glial_cell1.62496226
36MP0003950_abnormal_plasma_membrane1.62489952
37MP0005171_absent_coat_pigmentation1.61794177
38MP0003121_genomic_imprinting1.61037776
39MP0005551_abnormal_eye_electrophysiolog1.59444888
40MP0002067_abnormal_sensory_capabilities1.58535476
41MP0003195_calcinosis1.52465935
42MP0005409_darkened_coat_color1.50112235
43MP0008877_abnormal_DNA_methylation1.49218873
44MP0001970_abnormal_pain_threshold1.47846844
45MP0004924_abnormal_behavior1.47268965
46MP0005386_behavior/neurological_phenoty1.47268965
47MP0003890_abnormal_embryonic-extraembry1.45729502
48MP0002229_neurodegeneration1.42182017
49MP0002733_abnormal_thermal_nociception1.41235486
50MP0003879_abnormal_hair_cell1.38909287
51MP0001485_abnormal_pinna_reflex1.37613096
52MP0003123_paternal_imprinting1.36318354
53MP0002837_dystrophic_cardiac_calcinosis1.35874817
54MP0002735_abnormal_chemical_nociception1.23917757
55MP0004811_abnormal_neuron_physiology1.23175212
56MP0002066_abnormal_motor_capabilities/c1.22371901
57MP0003283_abnormal_digestive_organ1.22122372
58MP0009379_abnormal_foot_pigmentation1.21077627
59MP0002882_abnormal_neuron_morphology1.20157774
60MP0000955_abnormal_spinal_cord1.18714695
61MP0000604_amyloidosis1.17550408
62MP0003011_delayed_dark_adaptation1.16640646
63MP0005623_abnormal_meninges_morphology1.16539569
64MP0003632_abnormal_nervous_system1.15397231
65MP0003633_abnormal_nervous_system1.15219627
66MP0003631_nervous_system_phenotype1.13171197
67MP0001963_abnormal_hearing_physiology1.12163769
68MP0002557_abnormal_social/conspecific_i1.11621892
69MP0009780_abnormal_chondrocyte_physiolo1.10612321
70MP0008569_lethality_at_weaning1.09827767
71MP0002184_abnormal_innervation1.09070352
72MP0005503_abnormal_tendon_morphology1.07017219
73MP0000462_abnormal_digestive_system1.06925823
74MP0006072_abnormal_retinal_apoptosis1.05460876
75MP0002822_catalepsy1.04716826
76MP0002139_abnormal_hepatobiliary_system1.04389373
77MP0001984_abnormal_olfaction0.98412894
78MP0001502_abnormal_circadian_rhythm0.98381858
79MP0000013_abnormal_adipose_tissue0.97614410
80MP0008875_abnormal_xenobiotic_pharmacok0.97358674
81MP0002752_abnormal_somatic_nervous0.96728170
82MP0005379_endocrine/exocrine_gland_phen0.96186412
83MP0005187_abnormal_penis_morphology0.95938325
84MP0002928_abnormal_bile_duct0.93977141
85MP0005084_abnormal_gallbladder_morpholo0.93252158
86MP0005085_abnormal_gallbladder_physiolo0.93136498
87MP0002090_abnormal_vision0.92561668
88MP0003868_abnormal_feces_composition0.92535624
89MP0002295_abnormal_pulmonary_circulatio0.92079194
90MP0005083_abnormal_biliary_tract0.91922048
91MP0005410_abnormal_fertilization0.91672366
92MP0001188_hyperpigmentation0.91631587
93MP0008872_abnormal_physiological_respon0.90531931
94MP0005645_abnormal_hypothalamus_physiol0.90238834
95MP0004145_abnormal_muscle_electrophysio0.89623717
96MP0005646_abnormal_pituitary_gland0.89515828
97MP0003122_maternal_imprinting0.88674946
98MP0001664_abnormal_digestion0.87622575
99MP0002876_abnormal_thyroid_physiology0.86900569
100MP0005535_abnormal_body_temperature0.86303743
101MP0001756_abnormal_urination0.85587270
102MP0001299_abnormal_eye_distance/0.85305217
103MP0005332_abnormal_amino_acid0.83209463
104MP0001944_abnormal_pancreas_morphology0.83033013
105MP0001986_abnormal_taste_sensitivity0.82845872
106MP0010386_abnormal_urinary_bladder0.82825577
107MP0000026_abnormal_inner_ear0.81058496
108MP0000566_synostosis0.80786900
109MP0005195_abnormal_posterior_eye0.80029131
110MP0005451_abnormal_body_composition0.79569300
111MP0001661_extended_life_span0.79113056
112MP0000427_abnormal_hair_cycle0.78807104
113MP0000747_muscle_weakness0.78430158
114MP0001177_atelectasis0.78227115
115MP0002152_abnormal_brain_morphology0.76111638
116MP0003252_abnormal_bile_duct0.74211812
117MP0004272_abnormal_basement_membrane0.73552655
118MP0005636_abnormal_mineral_homeostasis0.71668893
119MP0004215_abnormal_myocardial_fiber0.71585413
120MP0000631_abnormal_neuroendocrine_gland0.70749926
121MP0001765_abnormal_ion_homeostasis0.69952011
122MP0005253_abnormal_eye_physiology0.69677096
123MP0000230_abnormal_systemic_arterial0.68498958
124MP0001879_abnormal_lymphatic_vessel0.68466025
125MP0004085_abnormal_heartbeat0.68252131
126MP0002069_abnormal_eating/drinking_beha0.65184710
127MP0005595_abnormal_vascular_smooth0.64105657
128MP0000762_abnormal_tongue_morphology0.63602557
129MP0004381_abnormal_hair_follicle0.61765405

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.25841318
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.62000523
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.62000523
4Cerebral inclusion bodies (HP:0100314)4.30259103
5Febrile seizures (HP:0002373)4.10653407
6Sensory axonal neuropathy (HP:0003390)3.60511282
7Parakeratosis (HP:0001036)3.58916520
8Abnormality of the corticospinal tract (HP:0002492)3.54814767
9Acute necrotizing encephalopathy (HP:0006965)3.49105659
10Focal motor seizures (HP:0011153)3.36584336
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.15558723
12Progressive macrocephaly (HP:0004481)3.14303931
13Acute encephalopathy (HP:0006846)3.08167698
14Myokymia (HP:0002411)2.98686067
15Abnormal mitochondria in muscle tissue (HP:0008316)2.94183383
16Supranuclear gaze palsy (HP:0000605)2.93845261
17Peripheral hypomyelination (HP:0007182)2.91684560
18Mitochondrial inheritance (HP:0001427)2.89719296
19Renal Fanconi syndrome (HP:0001994)2.86759427
20Atonic seizures (HP:0010819)2.85985868
21Abnormal eating behavior (HP:0100738)2.84070632
22Retinal dysplasia (HP:0007973)2.78766235
23Leukodystrophy (HP:0002415)2.70719008
24Insidious onset (HP:0003587)2.67024286
25Termporal pattern (HP:0011008)2.67024286
26Dysmetria (HP:0001310)2.62826120
27Increased circulating renin level (HP:0000848)2.62273808
28Metabolic alkalosis (HP:0200114)2.59889645
29Abnormality of glycolysis (HP:0004366)2.57994066
30Increased serum pyruvate (HP:0003542)2.57994066
31Drooling (HP:0002307)2.56984098
32Hyperventilation (HP:0002883)2.51596385
33Intention tremor (HP:0002080)2.50664184
34Cerebral hemorrhage (HP:0001342)2.48724453
35Focal seizures (HP:0007359)2.48684923
36Infantile muscular hypotonia (HP:0008947)2.48298662
37Scanning speech (HP:0002168)2.44255772
38Epileptiform EEG discharges (HP:0011182)2.43997975
39Status epilepticus (HP:0002133)2.43295846
40Hypokalemic alkalosis (HP:0001949)2.41270771
41Increased hepatocellular lipid droplets (HP:0006565)2.40214105
42Spastic gait (HP:0002064)2.39720293
43Epileptic encephalopathy (HP:0200134)2.37136188
44Torticollis (HP:0000473)2.36232760
45Pheochromocytoma (HP:0002666)2.31918933
46Excessive salivation (HP:0003781)2.29679364
47Hypothermia (HP:0002045)2.28618722
48Focal dystonia (HP:0004373)2.27947615
49Congenital, generalized hypertrichosis (HP:0004540)2.26403957
50Agitation (HP:0000713)2.25442686
51Postural tremor (HP:0002174)2.23822556
52Congenital ichthyosiform erythroderma (HP:0007431)2.22575981
53Abnormality of renal resorption (HP:0011038)2.19757889
54Sleep apnea (HP:0010535)2.19670793
55Increased CSF lactate (HP:0002490)2.19589169
56Nephronophthisis (HP:0000090)2.19204618
57EEG with generalized epileptiform discharges (HP:0011198)2.18473374
58Dialeptic seizures (HP:0011146)2.17652127
59Hypomagnesemia (HP:0002917)2.15909651
60Absence seizures (HP:0002121)2.15560650
61Optic disc pallor (HP:0000543)2.15369584
62Molar tooth sign on MRI (HP:0002419)2.14738718
63Abnormality of midbrain morphology (HP:0002418)2.14738718
64Cerebral edema (HP:0002181)2.13994695
65Hepatocellular necrosis (HP:0001404)2.13646547
66Generalized tonic-clonic seizures (HP:0002069)2.12345231
67Thickened helices (HP:0000391)2.11970959
68Neuroendocrine neoplasm (HP:0100634)2.10500473
69Macrocytic anemia (HP:0001972)2.10474410
70Onion bulb formation (HP:0003383)2.10164724
71Abnormal ciliary motility (HP:0012262)2.10102138
72Lipid accumulation in hepatocytes (HP:0006561)2.10003723
73Autoamputation (HP:0001218)2.09519883
74Hypochromic microcytic anemia (HP:0004840)2.08540606
75Aplasia involving bones of the extremities (HP:0009825)2.07095142
76Aplasia involving bones of the upper limbs (HP:0009823)2.07095142
77Aplasia of the phalanges of the hand (HP:0009802)2.07095142
78Abnormal pupillary function (HP:0007686)2.05728284
79Synostosis involving the elbow (HP:0003938)2.04783189
80Humeroradial synostosis (HP:0003041)2.04783189
81Vaginal atresia (HP:0000148)2.03987528
82Impaired vibration sensation in the lower limbs (HP:0002166)2.03355103
83Broad-based gait (HP:0002136)2.03035941
84Exertional dyspnea (HP:0002875)2.02412574
85Akinesia (HP:0002304)2.00491710
86Genital tract atresia (HP:0001827)2.00428241
87Pancreatic fibrosis (HP:0100732)2.00409326
88X-linked dominant inheritance (HP:0001423)1.99248562
89Hyperinsulinemic hypoglycemia (HP:0000825)1.98667938
90Generalized myoclonic seizures (HP:0002123)1.97946682
91Hypsarrhythmia (HP:0002521)1.97296021
92Abnormality of binocular vision (HP:0011514)1.97007353
93Diplopia (HP:0000651)1.97007353
94Hypoglycemic coma (HP:0001325)1.95504963
95Limb dystonia (HP:0002451)1.95331696
96Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94745580
97Clumsiness (HP:0002312)1.94160051
98Craniofacial dystonia (HP:0012179)1.93872450
99Spastic paraparesis (HP:0002313)1.93465413
100Glycosuria (HP:0003076)1.92811198
101Abnormality of urine glucose concentration (HP:0011016)1.92811198
102Abnormal drinking behavior (HP:0030082)1.92295966
103Polydipsia (HP:0001959)1.92295966
104Hemiparesis (HP:0001269)1.91213037
105Anxiety (HP:0000739)1.90648862
106Poor suck (HP:0002033)1.90333666
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90236336
108Gait imbalance (HP:0002141)1.90063822
109Hypophosphatemic rickets (HP:0004912)1.89182993
110Abnormal urine phosphate concentration (HP:0012599)1.88564280
111Absent/shortened dynein arms (HP:0200106)1.87195434
112Dynein arm defect of respiratory motile cilia (HP:0012255)1.87195434
113Abnormal hemoglobin (HP:0011902)1.86903902
114Fetal akinesia sequence (HP:0001989)1.86519487
115Papilledema (HP:0001085)1.85538490
116Incomplete penetrance (HP:0003829)1.85151983
117Visual hallucinations (HP:0002367)1.84898045
118Progressive cerebellar ataxia (HP:0002073)1.84839907
119Morphological abnormality of the pyramidal tract (HP:0002062)1.83896780
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82951996
121Abnormal auditory evoked potentials (HP:0006958)1.82380292
122Medial flaring of the eyebrow (HP:0010747)1.82321751
123Pancreatic cysts (HP:0001737)1.80713042
124Abnormality of the renal medulla (HP:0100957)1.80305271
125Abnormal respiratory motile cilium physiology (HP:0012261)1.80263282
126Methylmalonic acidemia (HP:0002912)1.80177139
127Rhinitis (HP:0012384)1.79220356
128Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78008000
129Confusion (HP:0001289)1.77578305
130Abnormal respiratory epithelium morphology (HP:0012253)1.73949513
131Abnormal respiratory motile cilium morphology (HP:0005938)1.73949513
132Megalencephaly (HP:0001355)1.73144558
133Ankle clonus (HP:0011448)1.73022747
134Respiratory failure (HP:0002878)1.70765462
135Nephrogenic diabetes insipidus (HP:0009806)1.70710151
136Septo-optic dysplasia (HP:0100842)1.69928934
137Increased intramyocellular lipid droplets (HP:0012240)1.69728768
138Hyperphosphaturia (HP:0003109)1.69590544
139Abnormality of cells of the erythroid lineage (HP:0012130)1.68797095
140Dysdiadochokinesis (HP:0002075)1.68277683
141Congenital primary aphakia (HP:0007707)1.67687130
142Bradykinesia (HP:0002067)1.67536688
143Anteriorly placed anus (HP:0001545)1.67512228
144Progressive inability to walk (HP:0002505)1.67135989
145Action tremor (HP:0002345)1.65303453
146Lower limb muscle weakness (HP:0007340)1.64803485
147Polyphagia (HP:0002591)1.64534614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.99824798
2OXSR14.05665298
3PNCK3.09072394
4WNK42.89801979
5CASK2.56740555
6MAPKAPK52.12872162
7EPHA42.07812057
8CDK192.06908247
9BCR2.04154528
10NTRK11.84657127
11PKN11.77277261
12TNIK1.77068679
13PINK11.76999015
14SGK21.73658670
15CAMKK21.73389152
16EPHB11.64324690
17FGFR21.62790863
18PBK1.60149325
19WNK11.59503709
20FGR1.59049152
21CAMK2B1.58221320
22MAP3K41.57058149
23NTRK31.56424708
24CSNK1G31.54824409
25MARK11.50503860
26FRK1.45668338
27MST41.43128960
28ARAF1.43085068
29UHMK11.42678430
30CSNK1G21.37678341
31DMPK1.35708690
32MAPK151.33596095
33MET1.32061904
34CAMK2D1.30427645
35GRK51.30301251
36NME11.28684738
37CAMK2A1.27301191
38CSNK1G11.26095309
39MAP3K91.24944454
40LATS21.24750296
41SGK11.24702260
42CSNK1A1L1.21730416
43MAP2K71.18942623
44ROCK21.17914062
45CAMKK11.14454046
46NEK61.13539073
47WNK31.09873103
48GRK71.09407142
49PAK31.07240614
50CAMK2G1.07102067
51LIMK11.04352537
52SGK2231.04217483
53SGK4941.04217483
54PRKCE0.98310010
55PAK60.98196626
56CDK50.96671654
57MUSK0.96586821
58STK240.96432985
59BMPR1B0.95800690
60MAP2K40.95444579
61PLK20.95020126
62FES0.94498162
63STK160.94317696
64SGK30.93198273
65CAMK10.92074476
66NTRK20.91075204
67MINK10.90571843
68MAP3K120.88707029
69RIPK40.85667602
70BMPR20.85314382
71CSNK1E0.85031602
72STK38L0.82579875
73CDK140.81738481
74EPHB20.79165699
75TAF10.78523116
76PHKG10.77106963
77PHKG20.77106963
78TYRO30.75280400
79PTK2B0.73352977
80SIK20.72991430
81DYRK1A0.72827750
82MAPK130.72303552
83PRKCQ0.69017283
84PRKCZ0.68019653
85CDK150.68005986
86ADRBK10.64916340
87FER0.64184012
88PRPF4B0.63859320
89CDK180.63723573
90ADRBK20.63600292
91ERBB40.63081961
92CAMK1G0.61522448
93IRAK20.60546119
94CDK11A0.60063072
95TIE10.58455528
96PRKCG0.58088976
97STK110.57525533
98PRKG10.57513218
99MKNK20.56140604
100RPS6KA30.55849333
101MAP3K20.54993162
102PDPK10.54509920
103KSR20.52462025
104DDR20.52433959
105ERBB30.51944630
106EIF2AK10.51173094
107MARK20.51161157
108FYN0.50695711
109PRKACA0.50524661
110MOS0.49283118
111PRKD10.47538256
112INSRR0.47521148
113MAP3K130.45850278
114MAPK120.44853208
115IRAK10.44688362
116MYLK0.44349212
117DYRK20.44244229
118ERBB20.44206054
119PRKCA0.43195674
120ALK0.42747335
121GRK10.42347956
122PIK3CA0.41793056
123CSNK1A10.41585731
124DAPK20.39322785
125GSK3A0.38551838
126PLK30.36932424
127CAMK1D0.36818096
128PRKCH0.35947825
129PRKACB0.35662775
130CDK30.35242154
131AKT30.34123701
132PRKACG0.31993006

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.45981566
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.01310163
3Fatty acid elongation_Homo sapiens_hsa000622.80495928
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.77803559
5Parkinsons disease_Homo sapiens_hsa050122.60128790
6Steroid biosynthesis_Homo sapiens_hsa001002.53413727
7Alzheimers disease_Homo sapiens_hsa050102.36814501
8Nicotine addiction_Homo sapiens_hsa050332.21512526
9Collecting duct acid secretion_Homo sapiens_hsa049662.02481137
10Sulfur metabolism_Homo sapiens_hsa009201.90944556
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86775462
12GABAergic synapse_Homo sapiens_hsa047271.84827270
13Ether lipid metabolism_Homo sapiens_hsa005651.79216613
14Ribosome_Homo sapiens_hsa030101.72419815
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72026433
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69766619
17Butanoate metabolism_Homo sapiens_hsa006501.65991650
18Cardiac muscle contraction_Homo sapiens_hsa042601.59194645
19Serotonergic synapse_Homo sapiens_hsa047261.58995050
20Huntingtons disease_Homo sapiens_hsa050161.57469587
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56440801
22Glutamatergic synapse_Homo sapiens_hsa047241.49867597
23Synaptic vesicle cycle_Homo sapiens_hsa047211.46978662
24Morphine addiction_Homo sapiens_hsa050321.40499762
25Histidine metabolism_Homo sapiens_hsa003401.39100924
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36249131
27Vibrio cholerae infection_Homo sapiens_hsa051101.35765690
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30046468
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29648913
30Long-term depression_Homo sapiens_hsa047301.23736306
31Caffeine metabolism_Homo sapiens_hsa002321.23614163
32* Protein export_Homo sapiens_hsa030601.22993130
33Cocaine addiction_Homo sapiens_hsa050301.20786244
34beta-Alanine metabolism_Homo sapiens_hsa004101.20196803
35Taste transduction_Homo sapiens_hsa047421.18017634
36Amphetamine addiction_Homo sapiens_hsa050311.16914301
37Salivary secretion_Homo sapiens_hsa049701.13898730
38Circadian entrainment_Homo sapiens_hsa047131.12782051
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12557650
40Sphingolipid metabolism_Homo sapiens_hsa006001.10847872
41Renin secretion_Homo sapiens_hsa049241.09799836
42Nitrogen metabolism_Homo sapiens_hsa009101.08541140
43Axon guidance_Homo sapiens_hsa043601.07289874
44Dopaminergic synapse_Homo sapiens_hsa047281.07003645
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03754276
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03348981
47Phototransduction_Homo sapiens_hsa047441.02748774
48Gastric acid secretion_Homo sapiens_hsa049711.01232921
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97734417
50Circadian rhythm_Homo sapiens_hsa047100.92770983
51Tryptophan metabolism_Homo sapiens_hsa003800.92643564
52Long-term potentiation_Homo sapiens_hsa047200.92630023
53Pancreatic secretion_Homo sapiens_hsa049720.92016635
54Propanoate metabolism_Homo sapiens_hsa006400.91672556
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91611005
56Linoleic acid metabolism_Homo sapiens_hsa005910.91483192
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90276289
58Insulin secretion_Homo sapiens_hsa049110.87546536
59Retinol metabolism_Homo sapiens_hsa008300.87044212
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84806502
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81012367
62Cholinergic synapse_Homo sapiens_hsa047250.80892423
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79593591
64Rheumatoid arthritis_Homo sapiens_hsa053230.78948205
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75788873
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.75769538
67Tyrosine metabolism_Homo sapiens_hsa003500.73968326
68Folate biosynthesis_Homo sapiens_hsa007900.73135068
69Arginine and proline metabolism_Homo sapiens_hsa003300.72095863
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71799104
71Olfactory transduction_Homo sapiens_hsa047400.69182370
72Fatty acid metabolism_Homo sapiens_hsa012120.69048133
73Pyruvate metabolism_Homo sapiens_hsa006200.68131855
74Calcium signaling pathway_Homo sapiens_hsa040200.68109265
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68047896
76Peroxisome_Homo sapiens_hsa041460.67857052
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67756940
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66233973
79Vitamin B6 metabolism_Homo sapiens_hsa007500.65736309
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63697481
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.62262897
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62087478
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.59475302
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58833622
85Gap junction_Homo sapiens_hsa045400.58056987
86Bile secretion_Homo sapiens_hsa049760.57613145
87Ovarian steroidogenesis_Homo sapiens_hsa049130.57557701
88Chemical carcinogenesis_Homo sapiens_hsa052040.56676595
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56633189
90Phenylalanine metabolism_Homo sapiens_hsa003600.54348118
91Oxytocin signaling pathway_Homo sapiens_hsa049210.53893170
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53072627
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53005897
94Estrogen signaling pathway_Homo sapiens_hsa049150.52578583
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52571831
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51925767
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51286588
98Renal cell carcinoma_Homo sapiens_hsa052110.51046981
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50984339
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50781462
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.49782361
102Fatty acid degradation_Homo sapiens_hsa000710.49030440
103Mineral absorption_Homo sapiens_hsa049780.48573485
104Thyroid hormone synthesis_Homo sapiens_hsa049180.46823758
105cAMP signaling pathway_Homo sapiens_hsa040240.46548668
106Fatty acid biosynthesis_Homo sapiens_hsa000610.46298138
107Metabolic pathways_Homo sapiens_hsa011000.45785112
108Regulation of autophagy_Homo sapiens_hsa041400.45409316
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45403777
110Complement and coagulation cascades_Homo sapiens_hsa046100.45100464
111Dorso-ventral axis formation_Homo sapiens_hsa043200.45014294
112Glutathione metabolism_Homo sapiens_hsa004800.44281898
113Arachidonic acid metabolism_Homo sapiens_hsa005900.44275249
114GnRH signaling pathway_Homo sapiens_hsa049120.44174569
115Melanogenesis_Homo sapiens_hsa049160.43072092
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.42192877
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.41720665
118PPAR signaling pathway_Homo sapiens_hsa033200.41545368
119Prion diseases_Homo sapiens_hsa050200.40619269
120Ras signaling pathway_Homo sapiens_hsa040140.39438007
121Phagosome_Homo sapiens_hsa041450.39327042
122Type II diabetes mellitus_Homo sapiens_hsa049300.39064553
123Basal transcription factors_Homo sapiens_hsa030220.38187882
124Glycerolipid metabolism_Homo sapiens_hsa005610.37555503
125ABC transporters_Homo sapiens_hsa020100.37239542

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