SEC63P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of Golgi to plasma membrane protein transport (GO:0042996)7.39109574
2regulation of meiosis I (GO:0060631)7.12440924
3monoubiquitinated protein deubiquitination (GO:0035520)7.02433059
4positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)6.90745204
5interkinetic nuclear migration (GO:0022027)6.17474737
6negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)5.91950746
7determination of adult lifespan (GO:0008340)5.34469777
8positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.98367320
9protein targeting to vacuole (GO:0006623)4.97243285
10protein targeting to lysosome (GO:0006622)4.97243285
11establishment of protein localization to vacuole (GO:0072666)4.97243285
12positive regulation of cAMP-mediated signaling (GO:0043950)4.90652542
13regulation of cellular senescence (GO:2000772)4.90058771
14protein K63-linked deubiquitination (GO:0070536)4.75885862
15embryonic heart tube development (GO:0035050)4.71136437
16forebrain morphogenesis (GO:0048853)4.53212790
17mitochondrion morphogenesis (GO:0070584)4.50852132
18thyroid gland development (GO:0030878)4.39647971
19positive regulation of growth hormone secretion (GO:0060124)4.37037618
20flavonoid metabolic process (GO:0009812)4.32132534
21microtubule severing (GO:0051013)4.29489363
22sulfation (GO:0051923)4.27496029
23glucosamine-containing compound catabolic process (GO:1901072)4.24917678
24growth hormone secretion (GO:0030252)4.09542942
25cellular response to ATP (GO:0071318)4.03362956
26regulation of dopamine secretion (GO:0014059)4.00627981
27positive regulation of interleukin-1 beta secretion (GO:0050718)3.97320130
28behavioral response to nicotine (GO:0035095)3.96396302
29protein localization to lysosome (GO:0061462)3.91306267
30protein localization to vacuole (GO:0072665)3.91306267
31cerebellar Purkinje cell differentiation (GO:0021702)3.89475039
32response to nitrosative stress (GO:0051409)3.87641062
33negative regulation of transcription by competitive promoter binding (GO:0010944)3.87101897
34nitric oxide metabolic process (GO:0046209)3.82689994
35protein K48-linked deubiquitination (GO:0071108)3.77786771
36dopamine transport (GO:0015872)3.76723579
37positive regulation of interleukin-1 secretion (GO:0050716)3.72918414
38cellular response to interferon-beta (GO:0035458)3.67142970
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.63890212
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.63890212
41regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.58507527
42phosphatidylinositol acyl-chain remodeling (GO:0036149)3.55615467
43regulation of interleukin-1 beta secretion (GO:0050706)3.50960124
44regulation of rhodopsin mediated signaling pathway (GO:0022400)3.48765408
45primitive streak formation (GO:0090009)3.48480683
46positive regulation of meiosis (GO:0045836)3.34367568
47pharyngeal system development (GO:0060037)3.33184690
48multicellular organism reproduction (GO:0032504)3.31534003
49rRNA methylation (GO:0031167)3.31186072
50oogenesis (GO:0048477)3.31057140
51histone deubiquitination (GO:0016578)3.29749761
52phosphatidylserine acyl-chain remodeling (GO:0036150)3.28514047
53lymphangiogenesis (GO:0001946)3.24224616
54rhodopsin mediated signaling pathway (GO:0016056)3.23447387
55fertilization (GO:0009566)3.22996828
56regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.22978681
57transmission of nerve impulse (GO:0019226)3.22068754
58regulation of nitric-oxide synthase activity (GO:0050999)3.21503478
59regulation of growth hormone secretion (GO:0060123)3.19210134
60otic vesicle formation (GO:0030916)3.15890930
61positive regulation of myoblast differentiation (GO:0045663)3.14371640
62positive regulation of fatty acid oxidation (GO:0046321)3.12199118
63negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)3.12187196
64water-soluble vitamin biosynthetic process (GO:0042364)3.10690067
65positive regulation of meiotic cell cycle (GO:0051446)3.08868405
66organ formation (GO:0048645)3.08416532
67protein-cofactor linkage (GO:0018065)3.08112105
68regulation of interleukin-1 secretion (GO:0050704)3.07334574
69tooth mineralization (GO:0034505)3.06740682
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05708293
71regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.01728200
72rRNA modification (GO:0000154)2.97984374
73positive regulation of digestive system process (GO:0060456)2.97374309
74phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.95921273
75sphingoid metabolic process (GO:0046519)2.93038412
76positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.90063632
77positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.89751137
78spermatid nucleus differentiation (GO:0007289)2.87408405
79DNA replication-dependent nucleosome organization (GO:0034723)2.86313344
80DNA replication-dependent nucleosome assembly (GO:0006335)2.86313344
81regulation of cell aging (GO:0090342)2.84682431
82estrogen metabolic process (GO:0008210)2.84636175
83positive regulation of B cell differentiation (GO:0045579)2.84465236
84negative regulation of mast cell activation (GO:0033004)2.80050256
85early endosome to late endosome transport (GO:0045022)2.77133181
86protein complex biogenesis (GO:0070271)2.74271674
87phenylpropanoid metabolic process (GO:0009698)2.73551988
88cell proliferation in forebrain (GO:0021846)2.73048229
89eye photoreceptor cell development (GO:0042462)2.72179564
90galactose catabolic process (GO:0019388)2.70118621
91photoreceptor cell maintenance (GO:0045494)2.69256209
92phosphatidylcholine acyl-chain remodeling (GO:0036151)2.68636326
93positive regulation of defense response to virus by host (GO:0002230)2.68175754
94epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.67713567
95regulation of phospholipid biosynthetic process (GO:0071071)2.66745651
96positive regulation of interleukin-1 beta production (GO:0032731)2.66289515
97phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.64980844
98regulation of cAMP-mediated signaling (GO:0043949)2.63085106
99NADH dehydrogenase complex assembly (GO:0010257)2.62675706
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62675706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.42270918
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.38638193
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.20884924
4VDR_22108803_ChIP-Seq_LS180_Human3.47792380
5IGF1R_20145208_ChIP-Seq_DFB_Human3.44929154
6ZNF274_21170338_ChIP-Seq_K562_Hela3.22578650
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78044034
8GBX2_23144817_ChIP-Seq_PC3_Human2.62450062
9EZH2_22144423_ChIP-Seq_EOC_Human2.59275643
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51057715
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.29271925
12TP53_16413492_ChIP-PET_HCT116_Human2.18958481
13ER_23166858_ChIP-Seq_MCF-7_Human2.16212818
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03607504
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.98368834
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.98368834
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.98368834
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.90449658
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88947816
20AR_21572438_ChIP-Seq_LNCaP_Human1.80440293
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.78876941
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78792188
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72668499
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.71813965
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68222521
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67072244
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.64249574
28SCL_19346495_ChIP-Seq_HPC-7_Human1.55926462
29FOXA1_21572438_ChIP-Seq_LNCaP_Human1.54969896
30TAF15_26573619_Chip-Seq_HEK293_Human1.53613203
31PRDM14_20953172_ChIP-Seq_ESCs_Human1.50289614
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.49557650
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49154077
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46513641
35EWS_26573619_Chip-Seq_HEK293_Human1.46157704
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45397705
37FUS_26573619_Chip-Seq_HEK293_Human1.44108512
38TP53_22573176_ChIP-Seq_HFKS_Human1.42552689
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41491793
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.38443770
41TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34842535
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32589945
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.31921233
44CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29413166
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28612514
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27168060
47SMRT_27268052_Chip-Seq_Bcells_Human1.26036290
48NANOG_19829295_ChIP-Seq_ESCs_Human1.25531157
49SOX2_19829295_ChIP-Seq_ESCs_Human1.25531157
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24742081
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24562900
52P300_19829295_ChIP-Seq_ESCs_Human1.24022065
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23999267
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21912143
55STAT3_23295773_ChIP-Seq_U87_Human1.21593396
56ELK1_19687146_ChIP-ChIP_HELA_Human1.21420288
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.21390362
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21226650
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.21226650
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.16923964
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16538894
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16262103
63FOXH1_21741376_ChIP-Seq_ESCs_Human1.15945892
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15398862
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14528544
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.13880534
67CDX2_22108803_ChIP-Seq_LS180_Human1.12345702
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12341681
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10741394
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10538272
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09217445
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07581579
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07160549
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06289012
75SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06130918
76CBP_20019798_ChIP-Seq_JUKART_Human1.05286111
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05286111
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03345814
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02388606
80TCF4_23295773_ChIP-Seq_U87_Human1.02000496
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01554552
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01494304
83AR_20517297_ChIP-Seq_VCAP_Human1.01335704
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.00199274
85NANOG_18555785_Chip-Seq_ESCs_Mouse0.99298223
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99064366
87DROSHA_22980978_ChIP-Seq_HELA_Human0.98658830
88TCF4_22108803_ChIP-Seq_LS180_Human0.98250759
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98144905
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97276136
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96292967
92MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96272218
93BCAT_22108803_ChIP-Seq_LS180_Human0.95214563
94MYC_19829295_ChIP-Seq_ESCs_Human0.94722733
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93816317
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.93707745
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92727473
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91043326
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90674424
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.90666156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.62488588
2MP0000569_abnormal_digit_pigmentation4.54287022
3MP0006292_abnormal_olfactory_placode4.05242099
4MP0002102_abnormal_ear_morphology3.54609547
5MP0002138_abnormal_hepatobiliary_system3.28937073
6MP0004134_abnormal_chest_morphology3.27268389
7MP0001529_abnormal_vocalization2.99785955
8MP0001501_abnormal_sleep_pattern2.87759524
9MP0005084_abnormal_gallbladder_morpholo2.76401806
10MP0004130_abnormal_muscle_cell2.53000436
11MP0008872_abnormal_physiological_respon2.51245424
12MP0005551_abnormal_eye_electrophysiolog2.48264325
13MP0003195_calcinosis2.45784802
14MP0000383_abnormal_hair_follicle2.21359630
15MP0004215_abnormal_myocardial_fiber2.06307622
16MP0003183_abnormal_peptide_metabolism1.84228064
17MP0005666_abnormal_adipose_tissue1.82730474
18MP0008875_abnormal_xenobiotic_pharmacok1.76742333
19MP0000631_abnormal_neuroendocrine_gland1.76561782
20MP0001664_abnormal_digestion1.75292017
21MP0002139_abnormal_hepatobiliary_system1.74978074
22MP0010386_abnormal_urinary_bladder1.68485122
23MP0001177_atelectasis1.60387796
24MP0001881_abnormal_mammary_gland1.56592903
25MP0004270_analgesia1.55491028
26MP0000678_abnormal_parathyroid_gland1.47422284
27MP0009250_abnormal_appendicular_skeleto1.36969585
28MP0003283_abnormal_digestive_organ1.35156859
29MP0003959_abnormal_lean_body1.31348796
30MP0002928_abnormal_bile_duct1.29653476
31MP0005503_abnormal_tendon_morphology1.24820152
32MP0003567_abnormal_fetal_cardiomyocyte1.20930867
33MP0000681_abnormal_thyroid_gland1.19221016
34MP0002971_abnormal_brown_adipose1.14932970
35MP0004185_abnormal_adipocyte_glucose1.13813051
36MP0000049_abnormal_middle_ear1.13438828
37MP0009379_abnormal_foot_pigmentation1.11127407
38MP0005389_reproductive_system_phenotype1.10935095
39MP0003646_muscle_fatigue1.09301814
40MP0004043_abnormal_pH_regulation1.07124849
41MP0001440_abnormal_grooming_behavior1.06877335
42MP0001485_abnormal_pinna_reflex1.03959809
43MP0004924_abnormal_behavior1.02676440
44MP0005386_behavior/neurological_phenoty1.02676440
45MP0002160_abnormal_reproductive_system1.02620642
46MP0004142_abnormal_muscle_tone1.02572339
47MP0004808_abnormal_hematopoietic_stem1.02248749
48MP0001502_abnormal_circadian_rhythm1.01030885
49MP0000733_abnormal_muscle_development0.97641616
50MP0008877_abnormal_DNA_methylation0.97518531
51MP0005253_abnormal_eye_physiology0.94546414
52MP0006072_abnormal_retinal_apoptosis0.91987582
53MP0000230_abnormal_systemic_arterial0.91914977
54MP0001879_abnormal_lymphatic_vessel0.91539116
55MP0003011_delayed_dark_adaptation0.90832719
56MP0002254_reproductive_system_inflammat0.89826052
57MP0009046_muscle_twitch0.88537963
58MP0005174_abnormal_tail_pigmentation0.87643173
59MP0001919_abnormal_reproductive_system0.87579193
60MP0000767_abnormal_smooth_muscle0.86144203
61MP0001324_abnormal_eye_pigmentation0.85700941
62MP0002115_abnormal_skeleton_extremities0.83488843
63MP0005409_darkened_coat_color0.82863561
64MP0002109_abnormal_limb_morphology0.82824904
65MP0001963_abnormal_hearing_physiology0.82763730
66MP0000647_abnormal_sebaceous_gland0.81394384
67MP0004264_abnormal_extraembryonic_tissu0.79602455
68MP0002148_abnormal_hypersensitivity_rea0.78168816
69MP0002733_abnormal_thermal_nociception0.77805149
70MP0008961_abnormal_basal_metabolism0.77405727
71MP0001486_abnormal_startle_reflex0.75728185
72MP0005195_abnormal_posterior_eye0.75681366
73MP0002111_abnormal_tail_morphology0.75669410
74MP0005375_adipose_tissue_phenotype0.74989719
75MP0005075_abnormal_melanosome_morpholog0.74809923
76MP0000427_abnormal_hair_cycle0.73590096
77MP0002557_abnormal_social/conspecific_i0.72986010
78MP0000163_abnormal_cartilage_morphology0.72290046
79MP0004145_abnormal_muscle_electrophysio0.70779930
80MP0002272_abnormal_nervous_system0.70593558
81MP0000538_abnormal_urinary_bladder0.70446821
82MP0003693_abnormal_embryo_hatching0.69448924
83MP0002734_abnormal_mechanical_nocicepti0.69048039
84MP0010678_abnormal_skin_adnexa0.68071921
85MP0003638_abnormal_response/metabolism_0.67926799
86MP0009115_abnormal_fat_cell0.67233495
87MP0001970_abnormal_pain_threshold0.67101163
88MP0001661_extended_life_span0.66879753
89MP0001800_abnormal_humoral_immune0.66463241
90MP0001765_abnormal_ion_homeostasis0.65807549
91MP0002249_abnormal_larynx_morphology0.64432030
92MP0000750_abnormal_muscle_regeneration0.63451235
93MP0002295_abnormal_pulmonary_circulatio0.62470760
94MP0005620_abnormal_muscle_contractility0.61187509
95MP0001986_abnormal_taste_sensitivity0.59623389
96MP0000566_synostosis0.59599663
97MP0001542_abnormal_bone_strength0.59138647
98MP0001905_abnormal_dopamine_level0.59134586
99MP0002736_abnormal_nociception_after0.58900288
100MP0002114_abnormal_axial_skeleton0.58297223

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.09809897
2Decreased central vision (HP:0007663)4.38678273
3Abolished electroretinogram (ERG) (HP:0000550)3.94644868
4Congenital stationary night blindness (HP:0007642)3.90851989
5Abnormality of macular pigmentation (HP:0008002)3.82453566
6Agitation (HP:0000713)3.75866503
7Central scotoma (HP:0000603)3.63527003
8Conjunctival hamartoma (HP:0100780)3.55707938
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.42095306
10Pendular nystagmus (HP:0012043)3.41104598
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.37598704
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.37598704
13Nonimmune hydrops fetalis (HP:0001790)3.26263017
14Pancreatic cysts (HP:0001737)3.19024636
15Disinhibition (HP:0000734)3.12511119
16Stomach cancer (HP:0012126)3.06895977
17Limb dystonia (HP:0002451)3.02359235
18Confusion (HP:0001289)3.02141201
19Abnormality of the 4th metacarpal (HP:0010012)2.96168916
20Furrowed tongue (HP:0000221)2.95522755
21Pancreatic fibrosis (HP:0100732)2.90089182
22Congenital, generalized hypertrichosis (HP:0004540)2.79568547
23True hermaphroditism (HP:0010459)2.74697442
24Biliary tract neoplasm (HP:0100574)2.71052813
25Dyschromatopsia (HP:0007641)2.68563832
26Long nose (HP:0003189)2.67712991
27Tubular atrophy (HP:0000092)2.65251079
28Reticulocytopenia (HP:0001896)2.65063001
29Nephronophthisis (HP:0000090)2.62904504
30Hamartoma of the eye (HP:0010568)2.60717921
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54633994
32Short 4th metacarpal (HP:0010044)2.54633994
33Abnormality of the corticospinal tract (HP:0002492)2.54140770
34Abnormal biliary tract morphology (HP:0012440)2.48057599
353-Methylglutaconic aciduria (HP:0003535)2.46076121
36Colon cancer (HP:0003003)2.43856901
37Congenital sensorineural hearing impairment (HP:0008527)2.43603162
38Neoplasm of the rectum (HP:0100743)2.42740079
39Methylmalonic acidemia (HP:0002912)2.40618612
40Diplopia (HP:0000651)2.39194570
41Abnormality of binocular vision (HP:0011514)2.39194570
42Ependymoma (HP:0002888)2.37871639
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.34112609
44Meningioma (HP:0002858)2.32681454
45Restlessness (HP:0000711)2.28644810
46Fair hair (HP:0002286)2.28175028
47Birth length less than 3rd percentile (HP:0003561)2.28153561
48Polydipsia (HP:0001959)2.21857085
49Abnormal drinking behavior (HP:0030082)2.21857085
50Attenuation of retinal blood vessels (HP:0007843)2.18302829
51Methylmalonic aciduria (HP:0012120)2.18000760
52Morphological abnormality of the pyramidal tract (HP:0002062)2.17861537
53Agnosia (HP:0010524)2.16494195
54Scotoma (HP:0000575)2.15980358
55Inability to walk (HP:0002540)2.12257393
56Angiofibromas (HP:0010615)2.12081702
57Adenoma sebaceum (HP:0009720)2.12081702
58Carpal bone hypoplasia (HP:0001498)2.11863093
59Abnormality of the renal cortex (HP:0011035)2.10878556
60Clumsiness (HP:0002312)2.10145688
61Hemiplegia (HP:0002301)2.08908328
62Anterior segment dysgenesis (HP:0007700)2.08851458
63Abnormal rod and cone electroretinograms (HP:0008323)2.08239154
64Abnormality of midbrain morphology (HP:0002418)2.08051464
65Molar tooth sign on MRI (HP:0002419)2.08051464
66Macular degeneration (HP:0000608)2.06053711
67Premature ovarian failure (HP:0008209)2.04319603
68Tetany (HP:0001281)2.03114377
69Abnormality of the prostate (HP:0008775)2.03068038
70Progressive cerebellar ataxia (HP:0002073)2.02982262
71Postaxial foot polydactyly (HP:0001830)2.02714500
72Stenosis of the external auditory canal (HP:0000402)2.02355897
73Chronic otitis media (HP:0000389)2.00871615
74Unilateral renal agenesis (HP:0000122)1.99635342
75Gaze-evoked nystagmus (HP:0000640)1.97680011
76Abnormality of ocular smooth pursuit (HP:0000617)1.96938369
77Oligodactyly (hands) (HP:0001180)1.96238298
78Prostate neoplasm (HP:0100787)1.95704163
79Inappropriate behavior (HP:0000719)1.95448551
80Dyskinesia (HP:0100660)1.94604647
81Benign neoplasm of the central nervous system (HP:0100835)1.94600484
82Sclerocornea (HP:0000647)1.93997373
83Lipid accumulation in hepatocytes (HP:0006561)1.93588987
84Synostosis of carpal bones (HP:0005048)1.93109140
85Chorioretinal atrophy (HP:0000533)1.92573225
86Partial agenesis of the corpus callosum (HP:0001338)1.86386777
87Abnormality of the renal medulla (HP:0100957)1.85691025
88Megalencephaly (HP:0001355)1.85269338
89Progressive inability to walk (HP:0002505)1.85205665
90Severe visual impairment (HP:0001141)1.84731218
91Spontaneous hematomas (HP:0007420)1.82580544
92Short hallux (HP:0010109)1.80891205
93Renal cortical cysts (HP:0000803)1.80531587
94Increased corneal curvature (HP:0100692)1.79756795
95Keratoconus (HP:0000563)1.79756795
96Asplenia (HP:0001746)1.79625177
97Conical tooth (HP:0000698)1.79165971
98Abnormality of the parietal bone (HP:0002696)1.79123952
99Constricted visual fields (HP:0001133)1.78567130
100Cystic liver disease (HP:0006706)1.76951979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKG26.48007340
2NUAK14.51015485
3MAP3K64.44628631
4PIK3CG3.32628551
5DMPK2.94497894
6MAP2K32.89981613
7FRK2.85204200
8GRK12.68701441
9PINK12.65879439
10MAP2K42.23168574
11STK242.22930911
12MAP2K62.11827033
13ZAK2.05147683
14CDK31.93591914
15WNK31.90298156
16ADRBK21.75672441
17TXK1.69734490
18PIK3CA1.58022132
19MAP4K21.58015102
20NEK91.50972845
21PLK41.39614332
22MAPK71.39327034
23PRKD21.34901590
24CLK11.30160358
25PRKCQ1.27930229
26MAPKAPK51.26715316
27STK38L1.22145162
28NME21.21353497
29ADRBK11.18068965
30MAP4K11.17120813
31RET1.07887166
32MAP3K121.06437789
33MAPK131.02726733
34IKBKB1.01543909
35NEK21.00426306
36STK160.95172811
37STK110.93552303
38ZAP700.91752237
39ILK0.90264418
40SYK0.81568190
41MAP3K50.81492743
42TLK10.80634385
43WNK40.79823281
44OXSR10.76223301
45CDK190.75418634
46NLK0.71651139
47PAK20.70094204
48TEC0.68456649
49CAMK2B0.67091426
50CHEK20.67048580
51PTK2B0.65878027
52DAPK20.65281205
53TAOK30.63050232
54MAPK40.62992652
55MAP3K110.62448951
56PDGFRB0.61183924
57RAF10.60393330
58MINK10.60366007
59PKN10.60321585
60PRKCE0.59926917
61PNCK0.59474579
62ITK0.59430021
63CSNK1G10.57883009
64MKNK20.57496463
65MAPKAPK30.57285520
66NME10.57267982
67CAMK2D0.55898255
68BTK0.55311627
69PRKCG0.55022999
70MAP3K70.50967636
71DYRK20.50564084
72ACVR1B0.50536965
73RPS6KA50.49364213
74STK30.48726838
75CAMK2A0.48148609
76NTRK20.46064893
77JAK30.45778898
78RPS6KB20.41032140
79LCK0.39161703
80PRKCH0.37952640
81BMPR1B0.36265180
82TRPM70.35468456
83INSRR0.35073797
84MYLK0.33409867
85LATS10.31760251
86PRKCZ0.31610865
87PRKCA0.31032785
88ABL20.30506767
89PRKACA0.28629532
90MET0.28115675
91RPS6KA60.26582115
92ABL10.22979336
93CAMK2G0.22389613
94FYN0.22258680
95PRKCB0.20666134
96PLK10.19474525
97INSR0.18975577
98OBSCN0.18250441
99CAMK10.18102766
100MATK0.16029198

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.08953286
2Linoleic acid metabolism_Homo sapiens_hsa005913.99248035
3Nicotine addiction_Homo sapiens_hsa050332.96129978
4Ether lipid metabolism_Homo sapiens_hsa005652.91114272
5Phototransduction_Homo sapiens_hsa047442.75444171
6Long-term depression_Homo sapiens_hsa047302.62797159
7Salivary secretion_Homo sapiens_hsa049702.11007360
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.06496014
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.99746253
10Ribosome_Homo sapiens_hsa030101.84368195
11Platelet activation_Homo sapiens_hsa046111.84173872
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80934245
13Olfactory transduction_Homo sapiens_hsa047401.77753100
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74641849
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.71969953
16Basal transcription factors_Homo sapiens_hsa030221.71654310
17Chemical carcinogenesis_Homo sapiens_hsa052041.59175814
18Renin secretion_Homo sapiens_hsa049241.57137841
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49864782
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46772469
21Ovarian steroidogenesis_Homo sapiens_hsa049131.45376510
22Asthma_Homo sapiens_hsa053101.42458549
23Arachidonic acid metabolism_Homo sapiens_hsa005901.42195082
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40499366
25Sulfur metabolism_Homo sapiens_hsa009201.34968828
26Homologous recombination_Homo sapiens_hsa034401.28318575
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27945828
28Fat digestion and absorption_Homo sapiens_hsa049751.26397444
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25030631
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.24869195
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24287559
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24079046
33Sphingolipid metabolism_Homo sapiens_hsa006001.16625713
34Circadian entrainment_Homo sapiens_hsa047131.16321421
35Starch and sucrose metabolism_Homo sapiens_hsa005001.10334065
36Glycerolipid metabolism_Homo sapiens_hsa005611.08981934
37Gap junction_Homo sapiens_hsa045401.07619592
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.04251679
39Serotonergic synapse_Homo sapiens_hsa047261.03876095
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.03584122
41Mismatch repair_Homo sapiens_hsa034301.02027873
42Primary immunodeficiency_Homo sapiens_hsa053400.99747176
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94036476
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.93211106
45Nitrogen metabolism_Homo sapiens_hsa009100.92195873
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90492131
47Parkinsons disease_Homo sapiens_hsa050120.89236416
48Selenocompound metabolism_Homo sapiens_hsa004500.88841283
49Histidine metabolism_Homo sapiens_hsa003400.86740805
50Oxidative phosphorylation_Homo sapiens_hsa001900.84207048
51Tryptophan metabolism_Homo sapiens_hsa003800.83470463
52Morphine addiction_Homo sapiens_hsa050320.83459888
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82395984
54Vitamin digestion and absorption_Homo sapiens_hsa049770.80193985
55Melanoma_Homo sapiens_hsa052180.80139531
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78755461
57Retinol metabolism_Homo sapiens_hsa008300.76263182
58Caffeine metabolism_Homo sapiens_hsa002320.75077620
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74864015
60Circadian rhythm_Homo sapiens_hsa047100.74572242
61Glutamatergic synapse_Homo sapiens_hsa047240.74380831
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73740267
63Fatty acid biosynthesis_Homo sapiens_hsa000610.72043457
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71178252
65Taste transduction_Homo sapiens_hsa047420.71129558
66RNA degradation_Homo sapiens_hsa030180.70852787
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66638845
68Lysosome_Homo sapiens_hsa041420.66587382
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66489267
70Pancreatic secretion_Homo sapiens_hsa049720.65191898
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63217239
72ABC transporters_Homo sapiens_hsa020100.61689369
73Autoimmune thyroid disease_Homo sapiens_hsa053200.61026797
74Oxytocin signaling pathway_Homo sapiens_hsa049210.60420801
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59363761
76VEGF signaling pathway_Homo sapiens_hsa043700.58537155
77Cholinergic synapse_Homo sapiens_hsa047250.57536915
78Graft-versus-host disease_Homo sapiens_hsa053320.55262871
79Cardiac muscle contraction_Homo sapiens_hsa042600.51935131
80Insulin secretion_Homo sapiens_hsa049110.50953870
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48809129
82Allograft rejection_Homo sapiens_hsa053300.47794549
83Calcium signaling pathway_Homo sapiens_hsa040200.46823700
84Fatty acid elongation_Homo sapiens_hsa000620.46502848
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46101268
86Mineral absorption_Homo sapiens_hsa049780.43468289
87Dopaminergic synapse_Homo sapiens_hsa047280.42594605
88Nucleotide excision repair_Homo sapiens_hsa034200.42266332
89Ras signaling pathway_Homo sapiens_hsa040140.41499107
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.38090188
91Sulfur relay system_Homo sapiens_hsa041220.37985412
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37634831
93Gastric acid secretion_Homo sapiens_hsa049710.37180429
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36623912
95Systemic lupus erythematosus_Homo sapiens_hsa053220.35476580
96RNA polymerase_Homo sapiens_hsa030200.35453667
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.32014195
98Butanoate metabolism_Homo sapiens_hsa006500.31965751
99Propanoate metabolism_Homo sapiens_hsa006400.31406921
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31202733

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