SECTM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.07614037
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.02637514
3negative regulation of cell killing (GO:0031342)5.94128331
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.94128331
5antigen processing and presentation of endogenous antigen (GO:0019883)5.82615710
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.66980510
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.33826597
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.33826597
9modulation by symbiont of host immune response (GO:0052553)5.33826597
10positive regulation by symbiont of host defense response (GO:0052509)5.33826597
11modulation by symbiont of host defense response (GO:0052031)5.33826597
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.33826597
13detection of other organism (GO:0098543)5.02737310
14neutrophil activation involved in immune response (GO:0002283)4.99588480
15detection of bacterium (GO:0016045)4.90361434
16positive regulation of gamma-delta T cell activation (GO:0046645)4.81683268
17macrophage activation involved in immune response (GO:0002281)4.74045173
18response to peptidoglycan (GO:0032494)4.47570345
19negative regulation of interleukin-12 production (GO:0032695)4.35016007
20immunoglobulin mediated immune response (GO:0016064)4.29483091
21detection of external biotic stimulus (GO:0098581)4.18927698
22cellular response to type I interferon (GO:0071357)4.15103353
23type I interferon signaling pathway (GO:0060337)4.15103353
24response to type I interferon (GO:0034340)4.11767893
25leukocyte aggregation (GO:0070486)4.01669661
26regulation of interferon-beta biosynthetic process (GO:0045357)3.99178132
27detection of molecule of bacterial origin (GO:0032490)3.82108525
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.72940255
29neutrophil activation (GO:0042119)3.67999879
30regulation of B cell receptor signaling pathway (GO:0050855)3.66193212
31regulation of dendritic cell antigen processing and presentation (GO:0002604)3.63908582
32detection of biotic stimulus (GO:0009595)3.63729065
33respiratory burst (GO:0045730)3.61442679
34leukocyte migration involved in inflammatory response (GO:0002523)3.61114180
35interferon-gamma-mediated signaling pathway (GO:0060333)3.58008545
36response to host immune response (GO:0052572)3.54189343
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.54189343
38granulocyte activation (GO:0036230)3.48665003
39regulation of gamma-delta T cell activation (GO:0046643)3.48160645
40regulation of T cell tolerance induction (GO:0002664)3.47684628
41regulation of mast cell degranulation (GO:0043304)3.42019608
42negative regulation of leukocyte mediated immunity (GO:0002704)3.41488243
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40037840
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.39085042
45cellular extravasation (GO:0045123)3.32596956
46response to host (GO:0075136)3.32052794
47response to host defenses (GO:0052200)3.32052794
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32052794
49antigen processing and presentation via MHC class Ib (GO:0002475)3.30941532
50myeloid cell activation involved in immune response (GO:0002275)3.28312003
51B cell mediated immunity (GO:0019724)3.28106821
52macrophage activation (GO:0042116)3.26465612
53microglial cell activation (GO:0001774)3.26080106
54germinal center formation (GO:0002467)3.24889133
55response to interleukin-15 (GO:0070672)3.22971942
56regulation of myeloid leukocyte mediated immunity (GO:0002886)3.21640175
57regulation of tolerance induction (GO:0002643)3.20203736
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.18968082
59regulation of T-helper 2 cell differentiation (GO:0045628)3.17186619
60defense response to protozoan (GO:0042832)3.16946851
61production of molecular mediator involved in inflammatory response (GO:0002532)3.14679395
62regulation of antigen processing and presentation (GO:0002577)3.13539214
63regulation of leukocyte degranulation (GO:0043300)3.11716104
64lipopolysaccharide-mediated signaling pathway (GO:0031663)3.11578551
65regulation of mast cell activation involved in immune response (GO:0033006)3.10879426
66negative regulation of T cell mediated immunity (GO:0002710)3.09073287
67positive regulation of antigen processing and presentation (GO:0002579)3.07470132
68negative regulation of cytokine production involved in immune response (GO:0002719)3.04900033
69dendritic cell chemotaxis (GO:0002407)3.04333110
70negative regulation of erythrocyte differentiation (GO:0045647)3.00928347
71positive regulation of Cdc42 GTPase activity (GO:0043089)2.94943919
72regulation of T cell mediated cytotoxicity (GO:0001914)2.92782683
73positive regulation of type 2 immune response (GO:0002830)2.92184704
74negative regulation of innate immune response (GO:0045824)2.91621775
75positive regulation of interferon-alpha production (GO:0032727)2.91096314
76NIK/NF-kappaB signaling (GO:0038061)2.89706826
77cellular response to interleukin-15 (GO:0071350)2.89529355
78response to muramyl dipeptide (GO:0032495)2.88302091
79response to interferon-alpha (GO:0035455)2.88017571
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86486730
81negative regulation of type 2 immune response (GO:0002829)2.85142891
82regulation of interferon-alpha production (GO:0032647)2.84564365
83positive regulation of mast cell activation (GO:0033005)2.84342988
84positive regulation of T cell mediated cytotoxicity (GO:0001916)2.83623517
85regulation of gamma-delta T cell differentiation (GO:0045586)2.82894802
86T-helper 1 type immune response (GO:0042088)2.81975188
87regulation of cellular extravasation (GO:0002691)2.81628698
88dendritic cell migration (GO:0036336)2.81561931
89neutrophil mediated immunity (GO:0002446)2.81524116
90regulation of type 2 immune response (GO:0002828)2.81395920
91myeloid dendritic cell differentiation (GO:0043011)2.80512954
92regulation of mast cell activation (GO:0033003)2.79753277
93response to protozoan (GO:0001562)2.78292579
94regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.75103877
95regulation of natural killer cell mediated immunity (GO:0002715)2.75103877
96cellular response to interferon-gamma (GO:0071346)2.72458036
97negative regulation of alpha-beta T cell activation (GO:0046636)2.71642796
98regulation of regulatory T cell differentiation (GO:0045589)2.68782694
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68772186
100negative regulation of interleukin-6 production (GO:0032715)2.68603676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human5.27175089
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.36391555
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.08974040
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.56314411
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07985093
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95184054
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.92446985
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80280538
9VDR_21846776_ChIP-Seq_THP-1_Human2.67067954
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66926684
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.60355444
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52824232
13VDR_24763502_ChIP-Seq_THP-1_Human2.49820956
14* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42508321
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.35944036
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.34361814
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25632810
18SPI1_23547873_ChIP-Seq_NB4_Human2.24058678
19SPI1_23127762_ChIP-Seq_K562_Human2.23823157
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22137078
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17543677
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11973218
23MAF_26560356_Chip-Seq_TH1_Human2.08738574
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.03530506
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99662020
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98959854
27* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98424216
28RUNX_20019798_ChIP-Seq_JUKART_Human1.97050915
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94551348
30LXR_22292898_ChIP-Seq_THP-1_Human1.87266451
31UTX_26944678_Chip-Seq_JUKART_Human1.84440990
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84215066
33TCF7_22412390_ChIP-Seq_EML_Mouse1.81189021
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.76290648
35MYC_22102868_ChIP-Seq_BL_Human1.75599086
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74801273
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.72836606
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72117686
39* MYB_26560356_Chip-Seq_TH2_Human1.70149080
40KDM2B_26808549_Chip-Seq_DND41_Human1.68290391
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65596499
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64967253
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63102510
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61451486
45SCL_19346495_ChIP-Seq_HPC-7_Human1.57379472
46VDR_24787735_ChIP-Seq_THP-1_Human1.55534657
47* MYB_26560356_Chip-Seq_TH1_Human1.55341457
48MAF_26560356_Chip-Seq_TH2_Human1.54157020
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52514193
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.52388328
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45190773
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.39270785
53PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34200306
54* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31370244
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30592603
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29770774
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29570933
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29423570
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29215012
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28727755
61* RACK7_27058665_Chip-Seq_MCF-7_Human1.25980971
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25901996
63BCL6_27268052_Chip-Seq_Bcells_Human1.25341729
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24269158
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22746406
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21467358
67BCOR_27268052_Chip-Seq_Bcells_Human1.20323772
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20305093
69GATA3_27048872_Chip-Seq_THYMUS_Human1.19903671
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18150155
71GATA1_19941826_ChIP-Seq_K562_Human1.16011859
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15766087
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15661564
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13204406
75GATA1_22025678_ChIP-Seq_K562_Human1.11045654
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09793104
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09684896
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09164980
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.08485773
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08454074
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07608384
82PU_27001747_Chip-Seq_BMDM_Mouse1.07295291
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06561825
84PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06008110
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.04367520
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03530998
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.01945376
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00819693
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.00740055
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99323921
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96288414
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92055423
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88739873
94TP63_17297297_ChIP-ChIP_HaCaT_Human0.88538656
95GATA3_26560356_Chip-Seq_TH2_Human0.87990065
96KDM2B_26808549_Chip-Seq_K562_Human0.87684469
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87568091
98* NCOR1_26117541_ChIP-Seq_K562_Human0.87563968
99* GATA2_19941826_ChIP-Seq_K562_Human0.84880357
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84813607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.88050532
2MP0003436_decreased_susceptibility_to4.17605543
3MP0003303_peritoneal_inflammation3.87210679
4MP0001835_abnormal_antigen_presentation3.56055481
5MP0006082_CNS_inflammation3.07314382
6MP0009785_altered_susceptibility_to3.02671654
7MP0002419_abnormal_innate_immunity2.93810726
8MP0005025_abnormal_response_to2.85965096
9MP0005387_immune_system_phenotype2.83890622
10MP0001790_abnormal_immune_system2.83890622
11MP0005671_abnormal_response_to2.66916634
12MP0005000_abnormal_immune_tolerance2.66714929
13MP0000685_abnormal_immune_system2.61675850
14MP0003300_gastrointestinal_ulcer2.58841555
15MP0001800_abnormal_humoral_immune2.55070873
16MP0002148_abnormal_hypersensitivity_rea2.47954912
17MP0010155_abnormal_intestine_physiology2.37547257
18MP0003191_abnormal_cellular_cholesterol2.36291501
19MP0002723_abnormal_immune_serum2.35902874
20MP0001533_abnormal_skeleton_physiology2.32265778
21MP0002452_abnormal_antigen_presenting2.28758413
22MP0002420_abnormal_adaptive_immunity2.21149025
23MP0001819_abnormal_immune_cell2.20631513
24MP0003183_abnormal_peptide_metabolism2.11200266
25MP0005058_abnormal_lysosome_morphology1.90168243
26MP0004510_myositis1.85792498
27MP0001845_abnormal_inflammatory_respons1.84559263
28MP0008260_abnormal_autophagy1.83125850
29MP0004947_skin_inflammation1.80998209
30MP0005451_abnormal_body_composition1.79175526
31MP0002405_respiratory_system_inflammati1.77028000
32MP0003866_abnormal_defecation1.72022601
33MP0009840_abnormal_foam_cell1.64673463
34MP0005464_abnormal_platelet_physiology1.64218431
35MP0003172_abnormal_lysosome_physiology1.63368534
36MP0008469_abnormal_protein_level1.60468981
37MP0003763_abnormal_thymus_physiology1.60358055
38MP0000716_abnormal_immune_system1.59575980
39MP0009764_decreased_sensitivity_to1.59141858
40MP0009333_abnormal_splenocyte_physiolog1.55778515
41MP0002398_abnormal_bone_marrow1.48178745
42MP0003075_altered_response_to1.47299843
43MP0009278_abnormal_bone_marrow1.44280946
44MP0000858_altered_metastatic_potential1.44228883
45MP0000465_gastrointestinal_hemorrhage1.43188929
46MP0002998_abnormal_bone_remodeling1.39815269
47MP0005360_urolithiasis1.39417701
48MP0005310_abnormal_salivary_gland1.39334191
49MP0002132_abnormal_respiratory_system1.37108037
50MP0003828_pulmonary_edema1.36725735
51MP0005166_decreased_susceptibility_to1.34941705
52MP0003806_abnormal_nucleotide_metabolis1.31878694
53MP0002277_abnormal_respiratory_mucosa1.25524961
54MP0002429_abnormal_blood_cell1.23189980
55MP0002722_abnormal_immune_system1.22059519
56MP0000689_abnormal_spleen_morphology1.20850197
57MP0003448_altered_tumor_morphology1.18259686
58MP0004858_abnormal_nervous_system1.17923993
59MP0000490_abnormal_crypts_of1.17755570
60MP0008004_abnormal_stomach_pH1.17258708
61MP0004883_abnormal_blood_vessel1.16192466
62MP0000343_altered_response_to1.16007689
63MP0001873_stomach_inflammation1.13653371
64MP0000604_amyloidosis1.08510458
65MP0005164_abnormal_response_to1.07870189
66MP0001663_abnormal_digestive_system1.06890622
67MP0001851_eye_inflammation1.06320728
68MP0002396_abnormal_hematopoietic_system1.05557434
69MP0005390_skeleton_phenotype1.04047058
70MP0005397_hematopoietic_system_phenotyp1.01674017
71MP0001545_abnormal_hematopoietic_system1.01674017
72MP0003690_abnormal_glial_cell0.98113837
73MP0000703_abnormal_thymus_morphology0.93772156
74MP0009763_increased_sensitivity_to0.86790671
75MP0003705_abnormal_hypodermis_morpholog0.86636381
76MP0005085_abnormal_gallbladder_physiolo0.84216201
77MP0002166_altered_tumor_susceptibility0.81886909
78MP0002138_abnormal_hepatobiliary_system0.80944010
79MP0002139_abnormal_hepatobiliary_system0.80213605
80MP0001853_heart_inflammation0.79664438
81MP0003453_abnormal_keratinocyte_physiol0.77179009
82MP0002933_joint_inflammation0.74268699
83MP0003795_abnormal_bone_structure0.74110240
84MP0005365_abnormal_bile_salt0.71058271
85MP0005319_abnormal_enzyme/_coenzyme0.70996602
86MP0003045_fibrosis0.70535141
87MP0004264_abnormal_extraembryonic_tissu0.70304406
88MP0000249_abnormal_blood_vessel0.70255677
89MP0006054_spinal_hemorrhage0.69719605
90MP0005381_digestive/alimentary_phenotyp0.69631892
91MP0001958_emphysema0.69390313
92MP0009765_abnormal_xenobiotic_induced0.68398508
93MP0003091_abnormal_cell_migration0.67542811
94MP0002254_reproductive_system_inflammat0.64028132
95MP0008874_decreased_physiological_sensi0.63094616
96MP0004381_abnormal_hair_follicle0.62816525
97MP0001542_abnormal_bone_strength0.62118758
98MP0003329_amyloid_beta_deposits0.58794211
99MP0005023_abnormal_wound_healing0.57080809
100MP0000609_abnormal_liver_physiology0.56808966

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.67435223
2Recurrent abscess formation (HP:0002722)5.51218253
3Myositis (HP:0100614)5.51170106
4Abnormality of macrophages (HP:0004311)5.47505199
5Orchitis (HP:0100796)5.37482192
6Recurrent bacterial skin infections (HP:0005406)5.36488526
7Retrobulbar optic neuritis (HP:0100654)4.77989447
8Optic neuritis (HP:0100653)4.77989447
9Recurrent gram-negative bacterial infections (HP:0005420)4.52128312
10Elevated erythrocyte sedimentation rate (HP:0003565)4.33134682
11Stomatitis (HP:0010280)4.15692386
12Gastrointestinal infarctions (HP:0005244)3.86654359
13Mediastinal lymphadenopathy (HP:0100721)3.82475152
14Obstructive lung disease (HP:0006536)3.80074329
15Chronic obstructive pulmonary disease (HP:0006510)3.80074329
16Gingivitis (HP:0000230)3.62000810
17Recurrent fungal infections (HP:0002841)3.60824496
18Meningitis (HP:0001287)3.51602958
19Recurrent skin infections (HP:0001581)3.44816867
20Spontaneous hematomas (HP:0007420)3.44377602
21Keratoconjunctivitis sicca (HP:0001097)3.42854399
22Increased IgE level (HP:0003212)3.42804155
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.40638549
24Encephalitis (HP:0002383)3.35259684
25Malnutrition (HP:0004395)3.32862426
26Systemic lupus erythematosus (HP:0002725)3.32410561
27Vasculitis (HP:0002633)3.32055637
28Urticaria (HP:0001025)3.24420549
29Keratoconjunctivitis (HP:0001096)3.13083212
30Peritonitis (HP:0002586)3.07449481
31Cellulitis (HP:0100658)3.01319732
32Amyloidosis (HP:0011034)2.99617798
33Abnormality of liposaccharide metabolism (HP:0010968)2.93007080
34Abnormality of glycosphingolipid metabolism (HP:0004343)2.93007080
35Abnormality of glycolipid metabolism (HP:0010969)2.93007080
36Pulmonary infiltrates (HP:0002113)2.92815680
37Hemoptysis (HP:0002105)2.91899549
38Chronic mucocutaneous candidiasis (HP:0002728)2.90431509
39Recurrent cutaneous fungal infections (HP:0011370)2.90431509
40Petechiae (HP:0000967)2.88027732
41Chest pain (HP:0100749)2.79399182
42Episodic fever (HP:0001954)2.78847941
43Hypochromic microcytic anemia (HP:0004840)2.77769790
44Loss of speech (HP:0002371)2.76948174
45Hypochromic anemia (HP:0001931)2.71648516
46Prolonged bleeding time (HP:0003010)2.61540329
47Increased IgM level (HP:0003496)2.59612954
48Pustule (HP:0200039)2.56811918
49Inflammation of the large intestine (HP:0002037)2.56021329
50Anorexia (HP:0002039)2.53574574
51Purpura (HP:0000979)2.53540442
52Increased cerebral lipofuscin (HP:0011813)2.50827868
53Gingival bleeding (HP:0000225)2.49943112
54Gastrointestinal inflammation (HP:0004386)2.49165577
55Leukocytosis (HP:0001974)2.44803244
56Recurrent viral infections (HP:0004429)2.44576720
57Pulmonary embolism (HP:0002204)2.40318004
58Arterial thrombosis (HP:0004420)2.38438606
59Dysostosis multiplex (HP:0000943)2.37275526
60Premature loss of primary teeth (HP:0006323)2.35704009
61Osteomyelitis (HP:0002754)2.34962338
62Hypergammaglobulinemia (HP:0010702)2.33704169
63T lymphocytopenia (HP:0005403)2.32216274
64Abnormality of T cell number (HP:0011839)2.31622048
65Epistaxis (HP:0000421)2.26317659
66Abnormality of the pleura (HP:0002103)2.25678194
67Abnormality of the nasal mucosa (HP:0000433)2.19897381
68Abnormality of the peritoneum (HP:0002585)2.19412208
69Colitis (HP:0002583)2.16943405
70Nasal polyposis (HP:0100582)2.16276453
71Gangrene (HP:0100758)2.15564161
72Increased serum ferritin (HP:0003281)2.15430389
73Abnormality of the pericardium (HP:0001697)2.13790624
74Hepatosplenomegaly (HP:0001433)2.10877930
75Disinhibition (HP:0000734)2.07083759
76Abnormality of T cells (HP:0002843)2.06438084
77Sepsis (HP:0100806)2.06109736
78Acne (HP:0001061)2.05683258
79Lymphopenia (HP:0001888)2.05172408
80Chronic otitis media (HP:0000389)2.04755738
81Granulocytopenia (HP:0001913)2.04123226
82Glomerulopathy (HP:0100820)2.02339226
83Microcytic anemia (HP:0001935)2.01821084
84Increased neuronal autofluorescent lipopigment (HP:0002074)2.00979198
85Chronic diarrhea (HP:0002028)2.00869090
86Vacuolated lymphocytes (HP:0001922)2.00716661
87Segmental peripheral demyelination/remyelination (HP:0003481)2.00464474
88Abnormality of cells of the lymphoid lineage (HP:0012140)1.97322228
89Abnormality of iron homeostasis (HP:0011031)1.97317305
90Autoimmune thrombocytopenia (HP:0001973)1.96043213
91Skin ulcer (HP:0200042)1.94432962
92Gastrointestinal stroma tumor (HP:0100723)1.94172498
93Polycythemia (HP:0001901)1.92420066
94Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90547047
95Abnormality of polysaccharide metabolism (HP:0011012)1.90547047
96Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90547047
97Interstitial pulmonary disease (HP:0006530)1.90234841
98Emphysema (HP:0002097)1.88999166
99Recurrent pneumonia (HP:0006532)1.88720495
100Abnormality of the endocardium (HP:0004306)1.88696753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.25992515
2ERN14.05867989
3MAP4K13.41070469
4TYK23.12345868
5IRAK42.99521804
6MAP2K32.71690639
7BLK2.68972715
8CSK2.57092668
9EPHB12.32336471
10PRPF4B2.24011477
11TAOK12.19920262
12GRK62.09252900
13TNK22.04836830
14MAP3K32.03780732
15ZAP702.03498782
16MAP3K111.98082775
17FES1.91362132
18JAK31.86518134
19TBK11.76162075
20FGR1.66343837
21IKBKE1.60775558
22MAP3K141.59061390
23BTK1.50647734
24HCK1.49608056
25TXK1.44431987
26RIPK11.41909518
27MAP3K11.41362810
28JAK11.37712152
29TRIB31.35091730
30SYK1.32499216
31SIK31.31432461
32TAOK21.30618562
33JAK21.28175356
34TESK21.25772177
35MATK1.25767184
36LYN1.20635123
37FGFR41.18861014
38CDC42BPA1.17313154
39PTK61.17214420
40MAP3K131.15141350
41KIT1.13132853
42PRKD21.12891771
43KSR21.10187222
44TGFBR21.07075853
45CSF1R1.04924281
46LCK1.03710567
47IRAK31.01236105
48SMG11.00656387
49PRKG20.93887017
50MARK20.92290131
51IRAK10.91952785
52IKBKB0.89708696
53YES10.89442620
54ACVR1B0.88988750
55SIK10.88911608
56GRK70.85907242
57PDPK10.85600792
58EPHA30.83791001
59PDK10.80103805
60MAP3K60.77100278
61MARK30.76223584
62IRAK20.75883879
63ITK0.68919013
64STK100.66364691
65BMPR20.65302711
66SIK20.64984818
67FYN0.64187596
68DYRK1B0.63811753
69FGFR30.62610532
70MAPK70.58173430
71TAOK30.57190924
72LRRK20.56890155
73HIPK20.56847698
74MAP3K20.56585979
75MAP3K50.54002686
76MAP3K70.52262081
77CDK190.51510086
78RPS6KL10.49089911
79RPS6KC10.49089911
80MAP2K60.47836800
81TEC0.46826805
82MAPK120.42625785
83STK380.42332006
84BMX0.41656606
85PAK40.41276500
86MAPKAPK20.41050544
87TESK10.40679748
88DDR20.39801953
89MOS0.39563179
90RPS6KA60.38430672
91RET0.37983054
92PTK2B0.37948511
93MAP2K40.35928859
94STK110.34562129
95PRKCD0.34270354
96PIM10.33509271
97MAP2K20.33354207
98MAP3K80.32592080
99PRKCQ0.32205998
100RPS6KA20.31970269

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.03210881
2Leishmaniasis_Homo sapiens_hsa051402.91296326
3Osteoclast differentiation_Homo sapiens_hsa043802.90925941
4Allograft rejection_Homo sapiens_hsa053302.61012758
5Graft-versus-host disease_Homo sapiens_hsa053322.53403515
6Autoimmune thyroid disease_Homo sapiens_hsa053202.36471495
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20201658
8Tuberculosis_Homo sapiens_hsa051522.08113793
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.06712988
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90386567
11Other glycan degradation_Homo sapiens_hsa005111.88301204
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.87291328
13Type I diabetes mellitus_Homo sapiens_hsa049401.84267257
14Malaria_Homo sapiens_hsa051441.81004445
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80878976
16B cell receptor signaling pathway_Homo sapiens_hsa046621.79692746
17Antigen processing and presentation_Homo sapiens_hsa046121.79407340
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66732647
19Asthma_Homo sapiens_hsa053101.64355391
20Primary immunodeficiency_Homo sapiens_hsa053401.63471700
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.62920572
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.62107507
23Viral myocarditis_Homo sapiens_hsa054161.61560602
24Toxoplasmosis_Homo sapiens_hsa051451.58838454
25Chemokine signaling pathway_Homo sapiens_hsa040621.55348105
26Influenza A_Homo sapiens_hsa051641.54175676
27Measles_Homo sapiens_hsa051621.51772898
28Hematopoietic cell lineage_Homo sapiens_hsa046401.49287032
29African trypanosomiasis_Homo sapiens_hsa051431.46170175
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45397538
31Acute myeloid leukemia_Homo sapiens_hsa052211.43586793
32Phagosome_Homo sapiens_hsa041451.43301656
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42958049
34Pertussis_Homo sapiens_hsa051331.40658034
35TNF signaling pathway_Homo sapiens_hsa046681.40373189
36Herpes simplex infection_Homo sapiens_hsa051681.31849738
37Legionellosis_Homo sapiens_hsa051341.31401541
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27087049
39Hepatitis C_Homo sapiens_hsa051601.26174813
40Rheumatoid arthritis_Homo sapiens_hsa053231.21060616
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.16920839
42T cell receptor signaling pathway_Homo sapiens_hsa046601.16597414
43Salmonella infection_Homo sapiens_hsa051321.15456521
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.13521822
45Lysosome_Homo sapiens_hsa041421.12762102
46Hepatitis B_Homo sapiens_hsa051610.98455044
47Shigellosis_Homo sapiens_hsa051310.94899313
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93244719
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93211488
50Renin-angiotensin system_Homo sapiens_hsa046140.88547678
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85863620
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85570887
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.85444363
54Apoptosis_Homo sapiens_hsa042100.83564151
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79615472
56Platelet activation_Homo sapiens_hsa046110.78056751
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.76918120
58Amoebiasis_Homo sapiens_hsa051460.76520885
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76442984
60VEGF signaling pathway_Homo sapiens_hsa043700.74074686
61Endocytosis_Homo sapiens_hsa041440.73884414
62Pancreatic cancer_Homo sapiens_hsa052120.72777701
63Vitamin digestion and absorption_Homo sapiens_hsa049770.71306813
64Prolactin signaling pathway_Homo sapiens_hsa049170.70852427
65Chronic myeloid leukemia_Homo sapiens_hsa052200.70834476
66Non-small cell lung cancer_Homo sapiens_hsa052230.70521567
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.69026422
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68740170
69Galactose metabolism_Homo sapiens_hsa000520.65006934
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.60758349
71Notch signaling pathway_Homo sapiens_hsa043300.57825888
72Fructose and mannose metabolism_Homo sapiens_hsa000510.57353815
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.56045707
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.53983884
75Epstein-Barr virus infection_Homo sapiens_hsa051690.52679646
76Renal cell carcinoma_Homo sapiens_hsa052110.50203106
77Insulin resistance_Homo sapiens_hsa049310.49984699
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49491552
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49161297
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48747937
81Fat digestion and absorption_Homo sapiens_hsa049750.48439868
82GnRH signaling pathway_Homo sapiens_hsa049120.47952116
83Mineral absorption_Homo sapiens_hsa049780.45747932
84HTLV-I infection_Homo sapiens_hsa051660.42454842
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.42272073
86Viral carcinogenesis_Homo sapiens_hsa052030.42025345
87FoxO signaling pathway_Homo sapiens_hsa040680.41217412
88Arachidonic acid metabolism_Homo sapiens_hsa005900.40775984
89Bladder cancer_Homo sapiens_hsa052190.38947762
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38170017
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37478260
92Choline metabolism in cancer_Homo sapiens_hsa052310.35884514
93Complement and coagulation cascades_Homo sapiens_hsa046100.34770430
94HIF-1 signaling pathway_Homo sapiens_hsa040660.34469038
95Prion diseases_Homo sapiens_hsa050200.33473484
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33125983
97Endometrial cancer_Homo sapiens_hsa052130.31908706
98PPAR signaling pathway_Homo sapiens_hsa033200.29605502
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.29089971
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28589232

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