SEL1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.58807807
2motile cilium assembly (GO:0044458)9.56139490
3spermatid development (GO:0007286)8.92607176
4piRNA metabolic process (GO:0034587)8.37871182
5cilium movement (GO:0003341)8.18978284
6regulation of cilium movement (GO:0003352)8.16921217
7male meiosis (GO:0007140)8.15163562
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.96278202
9single fertilization (GO:0007338)7.90244435
10synaptonemal complex organization (GO:0070193)7.35560626
11synaptonemal complex assembly (GO:0007130)7.25508755
12sperm capacitation (GO:0048240)7.14378177
13fertilization (GO:0009566)6.45851197
14spermatogenesis (GO:0007283)5.91953420
15male gamete generation (GO:0048232)5.89756050
16cellular ketone body metabolic process (GO:0046950)5.74685287
17microtubule depolymerization (GO:0007019)5.66328650
18negative regulation of inclusion body assembly (GO:0090084)5.48625484
19DNA methylation involved in gamete generation (GO:0043046)5.46125864
20gamete generation (GO:0007276)5.43261841
21ventricular system development (GO:0021591)5.33962253
22organic cation transport (GO:0015695)5.30943521
23cell recognition (GO:0008037)5.28463940
24microtubule severing (GO:0051013)5.22279117
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.18422073
26chromosome organization involved in meiosis (GO:0070192)5.10842072
27ketone body metabolic process (GO:1902224)5.03526836
28male meiosis I (GO:0007141)5.01582973
29germ cell development (GO:0007281)5.00090754
30calcium ion-dependent exocytosis (GO:0017156)4.93413372
31spermatid nucleus differentiation (GO:0007289)4.86413896
32regulation of microtubule-based movement (GO:0060632)4.69576497
33establishment of protein localization to Golgi (GO:0072600)4.67413963
34regulation of inclusion body assembly (GO:0090083)4.63038921
35meiotic nuclear division (GO:0007126)4.57005206
36glycine transport (GO:0015816)4.41839370
37seminiferous tubule development (GO:0072520)4.34892401
38multicellular organismal reproductive process (GO:0048609)4.28771773
39monoubiquitinated protein deubiquitination (GO:0035520)4.22822084
40protein targeting to Golgi (GO:0000042)4.07506373
41chaperone-mediated protein complex assembly (GO:0051131)4.05259495
42response to pheromone (GO:0019236)4.04994116
43meiosis I (GO:0007127)4.02757397
44angiogenesis involved in wound healing (GO:0060055)4.01744148
45glycerol ether metabolic process (GO:0006662)3.95316079
46regulation of appetite (GO:0032098)3.87843935
47protein K48-linked deubiquitination (GO:0071108)3.87599562
48serotonin receptor signaling pathway (GO:0007210)3.84314273
49sulfation (GO:0051923)3.83123881
50tryptophan catabolic process (GO:0006569)3.76067132
51indole-containing compound catabolic process (GO:0042436)3.76067132
52indolalkylamine catabolic process (GO:0046218)3.76067132
53retrograde transport, vesicle recycling within Golgi (GO:0000301)3.71261206
54protein localization to cilium (GO:0061512)3.71195617
55protein polyglutamylation (GO:0018095)3.67583513
56ether metabolic process (GO:0018904)3.64448367
57intraciliary transport (GO:0042073)3.63108025
58left/right pattern formation (GO:0060972)3.54571341
59meiotic cell cycle (GO:0051321)3.51703710
60genitalia morphogenesis (GO:0035112)3.45488879
61single strand break repair (GO:0000012)3.43577554
62multicellular organismal development (GO:0007275)3.43014639
63omega-hydroxylase P450 pathway (GO:0097267)3.34963849
64protein K11-linked deubiquitination (GO:0035871)3.33548599
65negative regulation of interleukin-8 production (GO:0032717)3.30963734
66nephron epithelium morphogenesis (GO:0072088)3.29148196
67nephron tubule morphogenesis (GO:0072078)3.29148196
68protein K63-linked deubiquitination (GO:0070536)3.28595363
69chromosome condensation (GO:0030261)3.28549078
70synapsis (GO:0007129)3.26808834
71regulation of sequestering of triglyceride (GO:0010889)3.26748470
72centriole assembly (GO:0098534)3.22373463
73carnitine metabolic process (GO:0009437)3.19430533
74alditol metabolic process (GO:0019400)3.16266298
75positive regulation of meiosis (GO:0045836)3.15126633
76primary amino compound metabolic process (GO:1901160)3.11380696
77polyol catabolic process (GO:0046174)3.11288173
78microtubule polymerization or depolymerization (GO:0031109)3.11118679
79negative regulation of Rho protein signal transduction (GO:0035024)3.10221952
80DNA packaging (GO:0006323)3.10122157
81cilium organization (GO:0044782)3.09831088
82cysteine metabolic process (GO:0006534)3.06966761
83phosphatidylethanolamine metabolic process (GO:0046337)3.06392031
84microtubule-based movement (GO:0007018)3.05913817
85rRNA methylation (GO:0031167)3.05694014
86gene silencing by RNA (GO:0031047)3.05262600
87axoneme assembly (GO:0035082)3.05241141
88amino-acid betaine transport (GO:0015838)3.04377722
89carnitine transport (GO:0015879)3.04377722
90detection of light stimulus involved in visual perception (GO:0050908)3.03125455
91detection of light stimulus involved in sensory perception (GO:0050962)3.03125455
92protein localization to Golgi apparatus (GO:0034067)3.02534766
93phosphatidylethanolamine biosynthetic process (GO:0006646)3.02000828
94positive regulation of vasculogenesis (GO:2001214)2.97920658
95centriole replication (GO:0007099)2.97670935
96cilium assembly (GO:0042384)2.97384613
97carnitine transmembrane transport (GO:1902603)2.96995438
98meiotic cell cycle process (GO:1903046)2.95864281
99cellular component assembly involved in morphogenesis (GO:0010927)2.95116002
100negative regulation of metanephros development (GO:0072217)2.94191333
101positive regulation of meiotic cell cycle (GO:0051446)2.93900248
102indole-containing compound metabolic process (GO:0042430)2.91972337
103retinol metabolic process (GO:0042572)2.91733608
104negative regulation of protein localization to cell surface (GO:2000009)2.90710226
105regulation of spindle checkpoint (GO:0090231)2.90100069
106low-density lipoprotein particle clearance (GO:0034383)2.87903078
107glycerol metabolic process (GO:0006071)2.86742858
108kynurenine metabolic process (GO:0070189)2.86432343
109icosanoid secretion (GO:0032309)2.85957993
110arachidonic acid secretion (GO:0050482)2.85957993
111GTP biosynthetic process (GO:0006183)2.85812788
112glycerophospholipid catabolic process (GO:0046475)2.83915553
113amino-acid betaine metabolic process (GO:0006577)2.83485310
114lymphangiogenesis (GO:0001946)2.83084424
115activated T cell proliferation (GO:0050798)2.82549418
116nucleoside diphosphate phosphorylation (GO:0006165)2.81169075
117cilium morphogenesis (GO:0060271)2.80164244
118lactate metabolic process (GO:0006089)2.79060879
119regulation of centriole replication (GO:0046599)2.77988164
120positive regulation of osteoblast proliferation (GO:0033690)2.74304186
121aromatic amino acid family catabolic process (GO:0009074)2.73381126
122regulation of Cdc42 GTPase activity (GO:0043088)2.71662967
123tryptophan metabolic process (GO:0006568)2.70849894
124negative regulation of organelle assembly (GO:1902116)2.69600085
125killing of cells of other organism (GO:0031640)2.67716471
126disruption of cells of other organism (GO:0044364)2.67716471
127positive regulation of hair follicle development (GO:0051798)2.66452318
128positive regulation of hair cycle (GO:0042635)2.66452318
129hematopoietic stem cell proliferation (GO:0071425)2.66002413
130sexual reproduction (GO:0019953)2.60571631
131glycolytic process (GO:0006096)2.59534644
132nucleus organization (GO:0006997)2.58939267
133mitotic sister chromatid cohesion (GO:0007064)2.57969030
134sequestering of actin monomers (GO:0042989)2.55864521
135UTP biosynthetic process (GO:0006228)2.53154056
136nuclear pore complex assembly (GO:0051292)2.52999089
137single-organism membrane fusion (GO:0044801)2.50766037
138protein refolding (GO:0042026)2.49151213
139regulation of meiosis I (GO:0060631)2.40799518
140positive regulation of macrophage activation (GO:0043032)2.39947106
141interferon-gamma secretion (GO:0072643)2.38875546
142fusion of sperm to egg plasma membrane (GO:0007342)15.0675739
143cell wall macromolecule catabolic process (GO:0016998)13.7311680
144cell wall macromolecule metabolic process (GO:0044036)13.7311680
145acrosome assembly (GO:0001675)12.8636416
146cilium or flagellum-dependent cell motility (GO:0001539)12.7994132
147multicellular organism reproduction (GO:0032504)12.5743515
148sperm motility (GO:0030317)12.2130667
149sperm-egg recognition (GO:0035036)11.9040295
150plasma membrane fusion (GO:0045026)11.4559790
151cell-cell recognition (GO:0009988)10.7376296
152axonemal dynein complex assembly (GO:0070286)10.4429591
153acrosome reaction (GO:0007340)10.3841550
154reproduction (GO:0000003)10.3590992
155binding of sperm to zona pellucida (GO:0007339)10.3122937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.57665284
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.34284271
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.74072248
4GBX2_23144817_ChIP-Seq_PC3_Human3.72747313
5EZH2_22144423_ChIP-Seq_EOC_Human3.72021736
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.41727417
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.80661600
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.78242070
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.57176203
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45632865
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.40271733
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31862366
13ZNF274_21170338_ChIP-Seq_K562_Hela2.18190319
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.15367716
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.13180516
16KAP1_22055183_ChIP-Seq_ESCs_Mouse2.10287301
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09587563
18DROSHA_22980978_ChIP-Seq_HELA_Human2.05870534
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.02531777
20AR_25329375_ChIP-Seq_VCAP_Human2.00089753
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.00028109
22CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.88867646
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88245789
24TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.87341916
25RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.86882705
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85732857
27VDR_22108803_ChIP-Seq_LS180_Human1.85434016
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81523294
29STAT1_17558387_ChIP-Seq_HELA_Human1.80293122
30GATA1_22025678_ChIP-Seq_K562_Human1.78222759
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.70931922
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67836909
33KDM2B_26808549_Chip-Seq_REH_Human1.64940886
34GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.64851696
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.63146471
36TAL1_26923725_Chip-Seq_HPCs_Mouse1.61355999
37SMAD4_21741376_ChIP-Seq_EPCs_Human1.59095544
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.57129819
39* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56680019
40* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56159406
41STAT3_23295773_ChIP-Seq_U87_Human1.55744074
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.55428125
43P300_19829295_ChIP-Seq_ESCs_Human1.54593577
44CBP_20019798_ChIP-Seq_JUKART_Human1.53082874
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53082874
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.52339433
47* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51144690
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48998532
49SMAD4_21799915_ChIP-Seq_A2780_Human1.47389627
50MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47140744
51FUS_26573619_Chip-Seq_HEK293_Human1.46748787
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45936180
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45343186
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.44020253
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.43347654
56FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42512081
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.41843973
58GATA3_21867929_ChIP-Seq_CD8_Mouse1.41696536
59* NANOG_18555785_Chip-Seq_ESCs_Mouse1.40458115
60IGF1R_20145208_ChIP-Seq_DFB_Human1.40000117
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39409443
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38543057
63ERA_21632823_ChIP-Seq_H3396_Human1.38171040
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37255503
65RNF2_27304074_Chip-Seq_NSC_Mouse1.37071215
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.36167846
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.35999359
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35717908
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.35562468
70* OCT4_18555785_Chip-Seq_ESCs_Mouse1.34874202
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32381931
72GATA3_21867929_ChIP-Seq_TH1_Mouse1.32168881
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32094958
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30814530
75TP53_18474530_ChIP-ChIP_U2OS_Human1.30436785
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29679445
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.29452245
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28919298
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.28723255
80RUNX2_22187159_ChIP-Seq_PCA_Human1.28624755
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28569808
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27683332
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26982363
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26982363
85* CMYC_18555785_Chip-Seq_ESCs_Mouse1.26496067
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26116901
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25844684
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25402763
89* P53_22387025_ChIP-Seq_ESCs_Mouse1.24958919
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24154446
91SOX2_22085726_ChIP-Seq_NPCs_Mouse1.23788763
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22972203
93* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22575450
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22095622
95* P300_18555785_Chip-Seq_ESCs_Mouse1.21518216
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20177316
97RUNX1_26923725_Chip-Seq_HPCs_Mouse1.20098545
98GF1_26923725_Chip-Seq_HPCs_Mouse1.19434293
99* KLF4_18555785_Chip-Seq_ESCs_Mouse1.19377961
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.19274321
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19152374
102CJUN_26792858_Chip-Seq_BT549_Human1.18821979
103SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18790546
104* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18628216
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18261278
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17924051
107* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17298299
108MYC_19829295_ChIP-Seq_ESCs_Human1.15990340
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15770173
110P53_21459846_ChIP-Seq_SAOS-2_Human1.14400076
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.13233819
112TCF4_22108803_ChIP-Seq_LS180_Human1.12418123
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.12268145
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11994891
115SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11890217
116SOX2_19829295_ChIP-Seq_ESCs_Human1.11772271
117NANOG_19829295_ChIP-Seq_ESCs_Human1.11772271
118TAF15_26573619_Chip-Seq_HEK293_Human1.11301739
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11110166
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11029066
121BCAT_22108803_ChIP-Seq_LS180_Human1.10966402
122GATA3_21878914_ChIP-Seq_MCF-7_Human1.10877217
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10169392
124REST_21632747_ChIP-Seq_MESCs_Mouse1.09887792
125FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09825226
126CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09621388
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09243721
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09243721
129SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08666310
130SPI1_26923725_Chip-Seq_HPCs_Mouse1.08163850
131AR_21572438_ChIP-Seq_LNCaP_Human1.07981201
132TCF4_23295773_ChIP-Seq_U87_Human1.07384694
133* SOX2_18555785_Chip-Seq_ESCs_Mouse1.05725498
134E2F1_18555785_Chip-Seq_ESCs_Mouse1.04866163
135MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04565507
136* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03923413
137* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03783988
138* CTCF_18555785_Chip-Seq_ESCs_Mouse1.03447400
139FOXH1_21741376_ChIP-Seq_ESCs_Human1.03371609
140SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01669505
141STAT3_18555785_ChIP-Seq_MESCs_Mouse1.01331469
142ERG_20517297_ChIP-Seq_VCAP_Human1.00881299
143SMAD4_21741376_ChIP-Seq_HESCs_Human1.00343908
144GF1B_26923725_Chip-Seq_HPCs_Mouse0.99905317
145* PU1_27457419_Chip-Seq_LIVER_Mouse0.99124480
146CDX2_22108803_ChIP-Seq_LS180_Human0.99105591
147EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98932093
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.98363276
149* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97550249
150JUN_21703547_ChIP-Seq_K562_Human0.97354179
151FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96465912
152FOXA1_25329375_ChIP-Seq_VCAP_Human0.96465912
153VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96083808
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.96007189
155* NMYC_18555785_Chip-Seq_ESCs_Mouse0.95970515
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95938029
157* ZFX_18555785_Chip-Seq_ESCs_Mouse0.95768783
158OCT4_20526341_ChIP-Seq_ESCs_Human0.95573619
159OCT1_27270436_Chip-Seq_PROSTATE_Human0.95429827
160RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93797553
161CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93265295
162EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92822288
163PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92573427
164ER_23166858_ChIP-Seq_MCF-7_Human0.91835371
165CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91658882
166LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89969237
167RARA_24833708_ChIP-Seq_LIVER_Mouse0.89353899
168PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88967059
169SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88942865
170* SOX9_26525672_Chip-Seq_HEART_Mouse0.88582668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.07587836
2MP0001929_abnormal_gametogenesis5.54768679
3MP0008877_abnormal_DNA_methylation4.97469491
4MP0002210_abnormal_sex_determination3.68450614
5MP0002653_abnormal_ependyma_morphology3.53100497
6MP0002161_abnormal_fertility/fecundity3.25950689
7MP0001145_abnormal_male_reproductive3.08006417
8MP0002139_abnormal_hepatobiliary_system2.84294844
9MP0000653_abnormal_sex_gland2.69553439
10MP0002138_abnormal_hepatobiliary_system2.58527504
11MP0005623_abnormal_meninges_morphology2.07514988
12MP0008875_abnormal_xenobiotic_pharmacok2.07487226
13MP0001486_abnormal_startle_reflex2.07292855
14MP0005410_abnormal_fertilization15.5092569
15MP0005167_abnormal_blood-brain_barrier1.92223285
16MP0005670_abnormal_white_adipose1.85891862
17MP0004130_abnormal_muscle_cell1.79688383
18MP0006276_abnormal_autonomic_nervous1.72040392
19MP0005647_abnormal_sex_gland1.69153133
20MP0008058_abnormal_DNA_repair1.69151662
21MP0001501_abnormal_sleep_pattern1.68163864
22MP0000230_abnormal_systemic_arterial1.54792675
23MP0008057_abnormal_DNA_replication1.53425660
24MP0002735_abnormal_chemical_nociception1.51119796
25MP0004142_abnormal_muscle_tone1.50390626
26MP0009046_muscle_twitch1.49367067
27MP0003195_calcinosis1.46840378
28MP0004215_abnormal_myocardial_fiber1.46500209
29MP0002160_abnormal_reproductive_system1.44167865
30MP0002282_abnormal_trachea_morphology1.42451905
31MP0010329_abnormal_lipoprotein_level1.41846930
32MP0005423_abnormal_somatic_nervous1.39325500
33MP0009745_abnormal_behavioral_response1.33968375
34MP0005379_endocrine/exocrine_gland_phen1.33919583
35MP0002254_reproductive_system_inflammat1.33868584
36MP0001879_abnormal_lymphatic_vessel1.26624675
37MP0005375_adipose_tissue_phenotype1.25521272
38MP0004233_abnormal_muscle_weight1.24766731
39MP0001485_abnormal_pinna_reflex1.22816282
40MP0003646_muscle_fatigue1.22628732
41MP0002272_abnormal_nervous_system1.19350875
42MP0003879_abnormal_hair_cell1.18753082
43MP0001970_abnormal_pain_threshold1.17021354
44MP0002064_seizures1.16363388
45MP0002970_abnormal_white_adipose1.15884936
46MP0000569_abnormal_digit_pigmentation1.15753879
47MP0001968_abnormal_touch/_nociception1.12224682
48MP0004043_abnormal_pH_regulation1.11710933
49MP0005595_abnormal_vascular_smooth1.10423272
50MP0003136_yellow_coat_color1.07023078
51MP0003718_maternal_effect1.05054328
52MP0005332_abnormal_amino_acid1.04808129
53MP0002733_abnormal_thermal_nociception1.04740908
54MP0001348_abnormal_lacrimal_gland1.01408097
55MP0001440_abnormal_grooming_behavior0.99747129
56MP0004085_abnormal_heartbeat0.99539116
57MP0010094_abnormal_chromosome_stability0.96975411
58MP0001984_abnormal_olfaction0.96101670
59MP0004084_abnormal_cardiac_muscle0.95099589
60MP0002118_abnormal_lipid_homeostasis0.95008001
61MP0001765_abnormal_ion_homeostasis0.93956465
62MP0000026_abnormal_inner_ear0.92595040
63MP0009053_abnormal_anal_canal0.92170436
64MP0000749_muscle_degeneration0.88331390
65MP0003635_abnormal_synaptic_transmissio0.87479156
66MP0002102_abnormal_ear_morphology0.86007107
67MP0000003_abnormal_adipose_tissue0.85565319
68MP0002572_abnormal_emotion/affect_behav0.83831880
69MP0001905_abnormal_dopamine_level0.82650836
70MP0005389_reproductive_system_phenotype0.82484738
71MP0002736_abnormal_nociception_after0.80930844
72MP0003724_increased_susceptibility_to0.80919537
73MP0005365_abnormal_bile_salt0.79879240
74MP0001963_abnormal_hearing_physiology0.79466880
75MP0003137_abnormal_impulse_conducting0.77398312
76MP0003283_abnormal_digestive_organ0.77327379
77MP0003638_abnormal_response/metabolism_0.76523051
78MP0002067_abnormal_sensory_capabilities0.76194733
79MP0002229_neurodegeneration0.75699065
80MP0005620_abnormal_muscle_contractility0.75488514
81MP0005448_abnormal_energy_balance0.75074258
82MP0005334_abnormal_fat_pad0.69914049
83MP0008995_early_reproductive_senescence0.69228568
84MP0005452_abnormal_adipose_tissue0.68141344
85MP0009697_abnormal_copulation0.67053868
86MP0002734_abnormal_mechanical_nocicepti0.66900438
87MP0008775_abnormal_heart_ventricle0.66177785
88MP0002234_abnormal_pharynx_morphology0.64748590
89MP0003786_premature_aging0.57451202
90MP0002928_abnormal_bile_duct0.57444448
91MP0002876_abnormal_thyroid_physiology0.57002483
92MP0003699_abnormal_female_reproductive0.56053473
93MP0000427_abnormal_hair_cycle0.55902301
94MP0003950_abnormal_plasma_membrane0.55132460
95MP0005310_abnormal_salivary_gland0.53523847
96MP0001119_abnormal_female_reproductive0.53181044
97MP0001764_abnormal_homeostasis0.52010564
98MP0001873_stomach_inflammation0.48170755
99MP0003959_abnormal_lean_body0.47549188
100MP0002971_abnormal_brown_adipose0.45785576
101MP0003011_delayed_dark_adaptation0.45234081
102MP0002405_respiratory_system_inflammati0.44555945
103MP0001346_abnormal_lacrimal_gland0.42687012
104MP0001835_abnormal_antigen_presentation0.42671868
105MP0003878_abnormal_ear_physiology0.42500981
106MP0005377_hearing/vestibular/ear_phenot0.42500981
107MP0009115_abnormal_fat_cell0.42442988
108MP0005636_abnormal_mineral_homeostasis0.42414860
109MP0004036_abnormal_muscle_relaxation0.41791490
110MP0010307_abnormal_tumor_latency0.40080505
111MP0003183_abnormal_peptide_metabolism0.38948045
112MP0008007_abnormal_cellular_replicative0.38303443
113MP0003111_abnormal_nucleus_morphology0.36500879
114MP0005551_abnormal_eye_electrophysiolog0.35858090
115MP0002269_muscular_atrophy0.35665049
116MP0005645_abnormal_hypothalamus_physiol0.35449814
117MP0006082_CNS_inflammation0.35058735
118MP0003115_abnormal_respiratory_system0.33360556
119MP0005397_hematopoietic_system_phenotyp0.31830140
120MP0001545_abnormal_hematopoietic_system0.31830140
121MP0001324_abnormal_eye_pigmentation0.31726997
122MP0000358_abnormal_cell_content/0.31484678
123MP0000685_abnormal_immune_system0.31466003
124MP0004019_abnormal_vitamin_homeostasis0.31260528
125MP0004510_myositis0.28572891
126MP0008872_abnormal_physiological_respon0.28347736
127MP0004808_abnormal_hematopoietic_stem0.27338901
128MP0005266_abnormal_metabolism0.27181684
129MP0005253_abnormal_eye_physiology0.26789134
130MP0001730_embryonic_growth_arrest0.25488477
131MP0006036_abnormal_mitochondrial_physio0.25072486
132MP0002133_abnormal_respiratory_system0.24908123
133MP0005388_respiratory_system_phenotype0.24908123
134MP0000313_abnormal_cell_death0.24889885
135MP0003633_abnormal_nervous_system0.23843983
136MP0001986_abnormal_taste_sensitivity0.23705319
137MP0001293_anophthalmia0.23600297
138MP0001851_eye_inflammation0.23239445
139MP0004134_abnormal_chest_morphology0.22606838
140MP0002009_preneoplasia0.21373434
141MP0001661_extended_life_span0.20021381
142MP0004145_abnormal_muscle_electrophysio0.19723333
143MP0005666_abnormal_adipose_tissue0.19688022
144MP0003948_abnormal_gas_homeostasis0.19410368
145MP0002693_abnormal_pancreas_physiology0.18706067
146MP0005535_abnormal_body_temperature0.18485489
147MP0005391_vision/eye_phenotype0.17464835
148MP0002295_abnormal_pulmonary_circulatio0.16358523
149MP0003861_abnormal_nervous_system0.16350154
150MP0001270_distended_abdomen0.16130248
151MP0003631_nervous_system_phenotype0.15866986
152MP0005195_abnormal_posterior_eye0.15762686
153MP0002169_no_abnormal_phenotype0.15730292
154MP0000432_abnormal_head_morphology0.15679310
155MP0002873_normal_phenotype0.15423065
156MP0002152_abnormal_brain_morphology0.15397032
157MP0003763_abnormal_thymus_physiology0.15198517
158MP0002132_abnormal_respiratory_system0.13493001
159MP0001919_abnormal_reproductive_system0.12781632

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.62724579
2Abnormal respiratory epithelium morphology (HP:0012253)8.97375400
3Abnormal respiratory motile cilium morphology (HP:0005938)8.97375400
4Abnormal ciliary motility (HP:0012262)8.11262231
5Rhinitis (HP:0012384)7.63134888
6Chronic bronchitis (HP:0004469)7.14076156
7Nasal polyposis (HP:0100582)6.62968870
8Congenital sensorineural hearing impairment (HP:0008527)6.02102931
9Infertility (HP:0000789)5.91388782
10Abnormality of the nasal mucosa (HP:0000433)5.42788118
11Attenuation of retinal blood vessels (HP:0007843)5.36734332
12Bony spicule pigmentary retinopathy (HP:0007737)5.04027354
13Severe visual impairment (HP:0001141)4.60806261
14Bronchiectasis (HP:0002110)4.58235417
15Bronchitis (HP:0012387)4.49260233
16Generalized aminoaciduria (HP:0002909)4.11425456
17Nephronophthisis (HP:0000090)3.94825595
18Abnormal rod and cone electroretinograms (HP:0008323)3.76241984
19Hyperkalemia (HP:0002153)3.75242119
20Male infertility (HP:0003251)3.73778195
21Abolished electroretinogram (ERG) (HP:0000550)3.70571740
22Pendular nystagmus (HP:0012043)3.67013803
23Absent rod-and cone-mediated responses on ERG (HP:0007688)3.63652475
24Recurrent sinusitis (HP:0011108)3.58495800
25Medial flaring of the eyebrow (HP:0010747)3.50094859
26Abnormal spermatogenesis (HP:0008669)3.31834559
27Recurrent otitis media (HP:0000403)3.19141600
28Decreased circulating renin level (HP:0003351)3.16387615
29Abnormality of macular pigmentation (HP:0008002)3.05898418
30Congenital stationary night blindness (HP:0007642)3.04598458
31Hypoplastic ischia (HP:0003175)3.03269280
32Abnormality of the renal medulla (HP:0100957)3.02847974
33Asymmetric septal hypertrophy (HP:0001670)2.89320203
34Resting tremor (HP:0002322)2.85029077
35Clumsiness (HP:0002312)2.76656990
36Recurrent bronchitis (HP:0002837)2.72716284
37Potter facies (HP:0002009)2.72636447
38Facial shape deformation (HP:0011334)2.72636447
39Abnormality of the ischium (HP:0003174)2.72542234
40Unilateral renal agenesis (HP:0000122)2.69542141
41Molar tooth sign on MRI (HP:0002419)2.69112106
42Abnormality of midbrain morphology (HP:0002418)2.69112106
43Hyperventilation (HP:0002883)2.64384923
44Lower limb hyperreflexia (HP:0002395)2.61472100
45Tubulointerstitial nephritis (HP:0001970)2.61429564
46Insulin-resistant diabetes mellitus (HP:0000831)2.55193247
47Keratoconus (HP:0000563)2.52512253
48Increased corneal curvature (HP:0100692)2.52512253
49Abnormality of dental color (HP:0011073)2.52235001
50Progressive cerebellar ataxia (HP:0002073)2.47994699
51Congenital primary aphakia (HP:0007707)2.45197741
52Gait imbalance (HP:0002141)2.44758457
53Ileus (HP:0002595)2.43406634
54Male pseudohermaphroditism (HP:0000037)2.42267538
55Azoospermia (HP:0000027)2.41814592
56Tubular atrophy (HP:0000092)2.37671513
57Acanthosis nigricans (HP:0000956)2.36882020
58Broad metatarsal (HP:0001783)2.28164711
59Tubulointerstitial abnormality (HP:0001969)2.24013147
60Retinal atrophy (HP:0001105)2.19868387
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18925693
62Gonadotropin excess (HP:0000837)2.18333786
63Proximal tubulopathy (HP:0000114)2.17107023
64Prominent supraorbital ridges (HP:0000336)2.15155373
65Congenital malformation of the right heart (HP:0011723)2.12940718
66Double outlet right ventricle (HP:0001719)2.12940718
67Tongue fasciculations (HP:0001308)2.12049802
68Absent speech (HP:0001344)2.11131298
69Nephrogenic diabetes insipidus (HP:0009806)2.10008796
70Hyperglycinuria (HP:0003108)2.09606388
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.09263261
72Mesangial abnormality (HP:0001966)2.06651860
73Abnormality of potassium homeostasis (HP:0011042)2.05753732
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02329540
75Myokymia (HP:0002411)2.01678461
76Postaxial foot polydactyly (HP:0001830)2.01591010
77Abnormal eating behavior (HP:0100738)2.01271823
78Genetic anticipation (HP:0003743)2.00220090
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6326549
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.0361633
81Absent/shortened dynein arms (HP:0200106)13.0361633
82Fibular hypoplasia (HP:0003038)1.98409927
83Impulsivity (HP:0100710)1.98373029
84Abnormality of urine glucose concentration (HP:0011016)1.97344344
85Glycosuria (HP:0003076)1.97344344
86Aplasia/Hypoplasia of the tibia (HP:0005772)1.96473296
87Abnormality of chloride homeostasis (HP:0011422)1.95990127
88Abnormality of the lower motor neuron (HP:0002366)1.94332646
89Abnormal urine output (HP:0012590)1.93436430
90Muscle fibrillation (HP:0010546)1.92910723
91Facial cleft (HP:0002006)1.91630818
92Ventricular fibrillation (HP:0001663)1.88374016
93Constricted visual fields (HP:0001133)1.87871467
94Microglossia (HP:0000171)1.87712148
95Chronic sinusitis (HP:0011109)1.87187439
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84985016
97Poor coordination (HP:0002370)1.84578353
98Genital tract atresia (HP:0001827)1.84252838
99Congenital hepatic fibrosis (HP:0002612)1.84085333
100Tubulointerstitial fibrosis (HP:0005576)1.83801988
101Hemiparesis (HP:0001269)1.83681941
102Photophobia (HP:0000613)1.83673949
103Action tremor (HP:0002345)1.83564262
104Polyphagia (HP:0002591)1.83036348
105Recurrent corneal erosions (HP:0000495)1.82746282
106Tachypnea (HP:0002789)1.82637502
107Hypophosphatemic rickets (HP:0004912)1.81930258
108Oligomenorrhea (HP:0000876)1.81905049
109Enlarged penis (HP:0000040)1.80494897
110Aplasia/Hypoplasia of the lens (HP:0008063)1.80289831
111Vaginal atresia (HP:0000148)1.79758671
112Retinitis pigmentosa (HP:0000510)1.79697898
113Pancreatic fibrosis (HP:0100732)1.78620916
114Polyuria (HP:0000103)1.76624785
115Hypoplasia of the uterus (HP:0000013)1.76620728
116Insulin resistance (HP:0000855)1.75725257
117Abnormal drinking behavior (HP:0030082)1.74829694
118Polydipsia (HP:0001959)1.74829694
119Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74480299
120Postaxial hand polydactyly (HP:0001162)1.74333764
121Tinnitus (HP:0000360)1.73776804
122Sclerocornea (HP:0000647)1.73177272
123Bilateral sensorineural hearing impairment (HP:0008619)1.71534054
124Stage 5 chronic kidney disease (HP:0003774)1.67609549
125Abnormality of the renal cortex (HP:0011035)1.66393535
126Median cleft lip (HP:0000161)1.62165827
127Renal dysplasia (HP:0000110)1.58262865
128Absent frontal sinuses (HP:0002688)1.57405231
129Short ribs (HP:0000773)1.57266285
130Abnormality of saccadic eye movements (HP:0000570)1.54284371
131Amyotrophic lateral sclerosis (HP:0007354)1.53841965
132Abnormality of renal excretion (HP:0011036)1.53646589
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.51927472
134Abnormality of the dental root (HP:0006486)1.49932662
135Taurodontia (HP:0000679)1.49932662
136Abnormality of permanent molar morphology (HP:0011071)1.49932662
137Decreased central vision (HP:0007663)1.49116875
138Oculomotor apraxia (HP:0000657)1.45782890
139Hypoplasia of the capital femoral epiphysis (HP:0003090)1.44724832
140J-shaped sella turcica (HP:0002680)1.43308455
141Supernumerary spleens (HP:0009799)1.41772694
142Heterotopia (HP:0002282)1.41422578
143Abnormality of molar (HP:0011077)1.41347594
144Abnormality of molar morphology (HP:0011070)1.41347594
145Cystic liver disease (HP:0006706)1.40944936
146Easy fatigability (HP:0003388)1.37152484
147Dyschromatopsia (HP:0007641)1.36353857
148Bile duct proliferation (HP:0001408)1.36334276
149Abnormal biliary tract physiology (HP:0012439)1.36334276
150Abnormality of ocular smooth pursuit (HP:0000617)1.36230554
151Abnormality of the dental pulp (HP:0006479)1.35570094
152Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.33957299
153Abnormality of dentin (HP:0010299)1.33803196
154Impaired proprioception (HP:0010831)1.31440280
155Aplasia/Hypoplasia of the fibula (HP:0006492)1.25526841
156Optic nerve hypoplasia (HP:0000609)1.25404892
157Abnormality of the neuromuscular junction (HP:0003398)1.25386711
158Fatigable weakness (HP:0003473)1.25386711
159True hermaphroditism (HP:0010459)1.24128837
160Spastic tetraparesis (HP:0001285)1.23671189
161Chronic hepatic failure (HP:0100626)1.20757817
162Hypoplasia of dental enamel (HP:0006297)1.20381721
163Short thorax (HP:0010306)1.20301038
164Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.19046404
165Type 2 muscle fiber atrophy (HP:0003554)1.18717621
166Transposition of the great arteries (HP:0001669)1.17912427
167Abnormal connection of the cardiac segments (HP:0011545)1.17912427
168Abnormal ventriculo-arterial connection (HP:0011563)1.17912427
169Pancreatic cysts (HP:0001737)1.16797721
170Deformed sella turcica (HP:0002681)1.16243729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.12621831
2PDK39.12621831
3FRK7.42491608
4PDK25.90871253
5TESK14.28655119
6PRKD33.68032025
7WNK33.37904179
8ICK3.02565145
9DDR22.61304130
10PTK2B2.45951500
11WNK42.35440127
12STK392.30924953
13TXK2.21556879
14CDK192.19875588
15PNCK1.81875343
16ADRBK21.73647997
17PIK3CG1.69314352
18GRK71.68763158
19NTRK31.67932525
20BLK1.55320835
21NEK21.44387549
22SIK21.34963006
23STK381.28203754
24CCNB11.25357353
25CAMK11.24952232
26DYRK31.15709527
27FER1.14443270
28PLK21.11440814
29BCKDK1.04840125
30CAMK1D1.04134723
31PDK11.03106946
32DYRK1B1.02546917
33MAP4K20.97753357
34FGFR20.96883719
35OXSR10.96667638
36TAOK30.96253985
37SIK10.93212196
38OBSCN0.92173053
39PLK40.92142032
40TYRO30.91693111
41ACVR1B0.91256950
42IRAK10.90574870
43ADRBK10.88392607
44MOS0.85459742
45NEK90.85306484
46LMTK20.84307510
47WNK10.80296796
48TIE10.78569791
49BRSK20.78314414
50MAPK150.77711548
51MAPK130.76816258
52AURKA0.74522282
53WEE10.74271274
54MAP3K90.74259342
55CHEK20.70935206
56PASK0.69986428
57CDK120.69116311
58PRKAA20.68524415
59STK30.68381280
60MYLK0.67706828
61STK38L0.66027929
62TRPM70.65153717
63MUSK0.62439193
64LIMK10.58112228
65MAP2K10.57659681
66TTK0.57628745
67MST1R0.56706986
68DAPK20.56162540
69MAPKAPK30.55606227
70TLK10.55113474
71CAMK40.53558846
72BRD40.53128296
73PRKACA0.51842443
74MARK10.50830810
75GRK50.50124755
76CHEK10.50113254
77CAMK1G0.49673419
78RPS6KA60.49478962
79RPS6KA20.49156680
80MAP2K60.47735975
81NLK0.46800111
82ABL20.46075849
83IGF1R0.43839329
84PDPK10.43584945
85PINK10.42972036
86PHKG20.42143374
87PHKG10.42143374
88PRKCA0.42070860
89MET0.41430506
90PRKACB0.40079351
91PLK10.39853936
92MAPK40.39242393
93PIK3CA0.38779046
94ARAF0.38429015
95CASK0.37871828
96ZAP700.37646107
97MAPK70.36350564
98JAK30.36299751
99NEK60.36074763
100IKBKB0.35950326
101RPS6KL10.35059591
102RPS6KC10.35059591
103CDC70.34979735
104ATM0.34624505
105TNK20.34080460
106CSF1R0.33993086
107MAP3K110.33099402
108PRKCH0.32893765
109PAK10.32845505
110ATR0.32811273
111EEF2K0.32314743
112SGK10.31355579
113TESK20.30840447
114EPHA30.27042370
115RIPK40.26867132
116CDK30.25521648
117MAP2K70.25196682
118BRSK10.23512511
119RPS6KB10.22496578
120PRKCG0.21663258
121BMPR1B0.21307669
122GRK10.20272213
123MAPKAPK50.20184582
124PKN10.16891742
125PRKCQ0.16782836
126MTOR0.15661062
127MARK30.15103564
128IRAK20.14797781
129PRKG20.14762565
130PRKAA10.14719404
131YES10.14052768
132STK110.13823291
133PRKCI0.13552148
134CAMKK10.12519060
135PAK20.11918979
136PDGFRB0.11389248
137CSNK2A10.09500725
138RIPK10.06420509
139CSNK2A20.06016232
140CDK90.05903095
141NTRK20.05595313
142MAPK80.05405865
143CDK10.05334921
144PRKG10.05290600
145GSK3B0.04511822
146PRKDC0.03782296
147RPS6KA10.03671780
148PRKACG0.03219407
149MAPK100.03191298
150PRKCD0.03060488
151CDK20.02889661
152MAP3K40.02633379
153PRKCZ0.02491689
154EPHB10.01881767
155PIM10.01734334
156CDK40.01247112
157EGFR0.01063194
158MELK0.00714058
159PRKCB-0.0293309
160CAMK2A-0.0256919
161TNIK-0.0188495
162EIF2AK1-0.0119057
163MAP3K10-0.0092983
164CDK15-0.0081817
165INSRR-0.0075265
166BRAF-0.0048878
167SYK-0.0019751

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.91184284
2Vitamin B6 metabolism_Homo sapiens_hsa007504.54836461
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.11646192
4Pyruvate metabolism_Homo sapiens_hsa006203.78514660
5Fatty acid biosynthesis_Homo sapiens_hsa000613.37106922
6Pentose phosphate pathway_Homo sapiens_hsa000303.35031832
7Butanoate metabolism_Homo sapiens_hsa006503.34735105
8Propanoate metabolism_Homo sapiens_hsa006403.28074051
9Basal transcription factors_Homo sapiens_hsa030223.21879225
10Glucagon signaling pathway_Homo sapiens_hsa049222.68275916
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.58811990
12Linoleic acid metabolism_Homo sapiens_hsa005912.55035656
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.53019302
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.38746217
15Nicotine addiction_Homo sapiens_hsa050332.34734779
16Fanconi anemia pathway_Homo sapiens_hsa034602.33786859
17Tryptophan metabolism_Homo sapiens_hsa003802.32488206
18Olfactory transduction_Homo sapiens_hsa047402.04657651
19Dorso-ventral axis formation_Homo sapiens_hsa043202.03261121
20Selenocompound metabolism_Homo sapiens_hsa004502.01397751
21Glycerolipid metabolism_Homo sapiens_hsa005612.00544320
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.93797867
23Oocyte meiosis_Homo sapiens_hsa041141.92609315
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88618957
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86802609
26Histidine metabolism_Homo sapiens_hsa003401.65256395
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.63773061
28Huntingtons disease_Homo sapiens_hsa050161.58867491
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.58234226
30PPAR signaling pathway_Homo sapiens_hsa033201.56574263
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52398819
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49810708
33Amphetamine addiction_Homo sapiens_hsa050311.45756156
34Fatty acid elongation_Homo sapiens_hsa000621.45543380
35Morphine addiction_Homo sapiens_hsa050321.39270471
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38398675
37Carbon metabolism_Homo sapiens_hsa012001.37796117
38Retinol metabolism_Homo sapiens_hsa008301.37748669
39Biosynthesis of amino acids_Homo sapiens_hsa012301.37434448
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.36742302
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36343590
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.35266843
43Antigen processing and presentation_Homo sapiens_hsa046121.34560703
44mRNA surveillance pathway_Homo sapiens_hsa030151.33353832
45Purine metabolism_Homo sapiens_hsa002301.29223524
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27747361
47Fructose and mannose metabolism_Homo sapiens_hsa000511.26445202
48Phototransduction_Homo sapiens_hsa047441.24644522
49* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24051474
50RNA transport_Homo sapiens_hsa030131.20395483
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12560569
52Ether lipid metabolism_Homo sapiens_hsa005651.10380386
53Renin secretion_Homo sapiens_hsa049241.05489583
54Renin-angiotensin system_Homo sapiens_hsa046141.05331339
55Mineral absorption_Homo sapiens_hsa049781.04292476
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03893292
57Serotonergic synapse_Homo sapiens_hsa047260.98569011
58beta-Alanine metabolism_Homo sapiens_hsa004100.98428893
59Cardiac muscle contraction_Homo sapiens_hsa042600.97120021
60Phenylalanine metabolism_Homo sapiens_hsa003600.95393080
61ABC transporters_Homo sapiens_hsa020100.94232799
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92110545
63Fat digestion and absorption_Homo sapiens_hsa049750.91712731
64GABAergic synapse_Homo sapiens_hsa047270.88505216
65Peroxisome_Homo sapiens_hsa041460.88420531
66Arginine and proline metabolism_Homo sapiens_hsa003300.87940037
67Asthma_Homo sapiens_hsa053100.87050169
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84943832
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81365816
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.80402570
71Staphylococcus aureus infection_Homo sapiens_hsa051500.79929119
72Glutamatergic synapse_Homo sapiens_hsa047240.79457741
73Fatty acid degradation_Homo sapiens_hsa000710.79332681
74Nitrogen metabolism_Homo sapiens_hsa009100.78379714
75Starch and sucrose metabolism_Homo sapiens_hsa005000.77771822
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77405721
77Sulfur relay system_Homo sapiens_hsa041220.76086811
78Fatty acid metabolism_Homo sapiens_hsa012120.73280775
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71694711
80N-Glycan biosynthesis_Homo sapiens_hsa005100.71465463
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69515919
82Cocaine addiction_Homo sapiens_hsa050300.69349424
83Tyrosine metabolism_Homo sapiens_hsa003500.66173907
84Calcium signaling pathway_Homo sapiens_hsa040200.65716102
85Oxidative phosphorylation_Homo sapiens_hsa001900.65321531
86Arachidonic acid metabolism_Homo sapiens_hsa005900.65296095
87Long-term potentiation_Homo sapiens_hsa047200.62732448
88Cholinergic synapse_Homo sapiens_hsa047250.59929025
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59159144
90Chemical carcinogenesis_Homo sapiens_hsa052040.57067678
91Taste transduction_Homo sapiens_hsa047420.56427396
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54583735
93Parkinsons disease_Homo sapiens_hsa050120.54386838
94Glutathione metabolism_Homo sapiens_hsa004800.53623733
95Homologous recombination_Homo sapiens_hsa034400.53122141
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52522776
97Legionellosis_Homo sapiens_hsa051340.51992708
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50305389
99Estrogen signaling pathway_Homo sapiens_hsa049150.49259774
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48664983
101Inositol phosphate metabolism_Homo sapiens_hsa005620.48434511
102Oxytocin signaling pathway_Homo sapiens_hsa049210.48227790
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46315025
104Cell cycle_Homo sapiens_hsa041100.45803466
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45287769
106Insulin secretion_Homo sapiens_hsa049110.45188549
107Metabolic pathways_Homo sapiens_hsa011000.45017933
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43503208
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.43459709
110Collecting duct acid secretion_Homo sapiens_hsa049660.41646382
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41095858
112Alzheimers disease_Homo sapiens_hsa050100.40590101
113Thyroid hormone synthesis_Homo sapiens_hsa049180.39732920
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.38582153
115RNA degradation_Homo sapiens_hsa030180.38181576
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37955313
117Systemic lupus erythematosus_Homo sapiens_hsa053220.37441831
118Lysosome_Homo sapiens_hsa041420.36268840
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35577625
120Protein digestion and absorption_Homo sapiens_hsa049740.34614396
121Lysine degradation_Homo sapiens_hsa003100.34564975
122Endocytosis_Homo sapiens_hsa041440.33437373
123Type II diabetes mellitus_Homo sapiens_hsa049300.32716917
124Bile secretion_Homo sapiens_hsa049760.32544719
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31684434
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30987724
127AMPK signaling pathway_Homo sapiens_hsa041520.30229566
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.29598396
129Pyrimidine metabolism_Homo sapiens_hsa002400.29007360
130Salivary secretion_Homo sapiens_hsa049700.27858628
131Graft-versus-host disease_Homo sapiens_hsa053320.26663519
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25836296
133Hedgehog signaling pathway_Homo sapiens_hsa043400.25221474
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24898634
135Pancreatic secretion_Homo sapiens_hsa049720.23995762
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22241022
137VEGF signaling pathway_Homo sapiens_hsa043700.21324294
138cAMP signaling pathway_Homo sapiens_hsa040240.20393477
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18342647
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.17587759
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16986392
142Synaptic vesicle cycle_Homo sapiens_hsa047210.16653103
143Measles_Homo sapiens_hsa051620.14475699
144Vitamin digestion and absorption_Homo sapiens_hsa049770.13761077
145Gastric acid secretion_Homo sapiens_hsa049710.13696161
146Salmonella infection_Homo sapiens_hsa051320.12578617
147Circadian entrainment_Homo sapiens_hsa047130.12029266
148Ovarian steroidogenesis_Homo sapiens_hsa049130.11754904
149Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10102745
150Viral carcinogenesis_Homo sapiens_hsa052030.08758629

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