SEL1L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)5.07817328
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.05627111
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.00266248
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.66146191
5B cell receptor signaling pathway (GO:0050853)4.62388710
6vocalization behavior (GO:0071625)4.30014251
7regulation of B cell receptor signaling pathway (GO:0050855)4.16666016
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.13386648
9complement activation, classical pathway (GO:0006958)3.69720153
10regulation of synaptic vesicle exocytosis (GO:2000300)3.65203711
11cellular potassium ion homeostasis (GO:0030007)3.64332373
12surfactant homeostasis (GO:0043129)3.62759238
13germinal center formation (GO:0002467)3.57505684
14positive regulation of gamma-delta T cell activation (GO:0046645)3.56506279
15glutamate secretion (GO:0014047)3.52714707
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.48757614
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.43622894
18locomotory exploration behavior (GO:0035641)3.40041266
19antigen processing and presentation via MHC class Ib (GO:0002475)3.39514229
20synaptic vesicle maturation (GO:0016188)3.33429255
21neuron cell-cell adhesion (GO:0007158)3.33327890
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.32955580
23synaptic vesicle exocytosis (GO:0016079)3.32451065
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.30154475
25potassium ion homeostasis (GO:0055075)3.29505324
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.28733272
27neuronal action potential propagation (GO:0019227)3.27829363
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.26833354
29protein targeting to Golgi (GO:0000042)3.25764071
30B cell proliferation (GO:0042100)3.23666705
31sodium ion export (GO:0071436)3.19915101
32branching involved in prostate gland morphogenesis (GO:0060442)3.18777784
33synaptic transmission, glutamatergic (GO:0035249)3.18698937
34gonadal mesoderm development (GO:0007506)3.18557680
35renal filtration (GO:0097205)3.17195534
36glutamate receptor signaling pathway (GO:0007215)3.16786345
37regulation of synaptic vesicle transport (GO:1902803)3.14227674
38negative regulation of cell killing (GO:0031342)3.11388001
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11388001
40peptide catabolic process (GO:0043171)3.10686229
41neurotransmitter secretion (GO:0007269)3.10455248
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.08914513
43glomerular filtration (GO:0003094)3.08820007
44regulation of interferon-beta biosynthetic process (GO:0045357)3.07053247
45positive regulation of synapse maturation (GO:0090129)3.03606469
46positive thymic T cell selection (GO:0045059)3.03170437
47immunoglobulin mediated immune response (GO:0016064)3.02585031
48gamma-aminobutyric acid transport (GO:0015812)3.00358242
49regulation of glutamate receptor signaling pathway (GO:1900449)2.99702858
50proline transport (GO:0015824)2.98749941
51regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96342143
52L-fucose catabolic process (GO:0042355)2.95992862
53fucose catabolic process (GO:0019317)2.95992862
54L-fucose metabolic process (GO:0042354)2.95992862
55cerebellar granule cell differentiation (GO:0021707)2.95987358
56positive regulation of B cell differentiation (GO:0045579)2.95985553
57negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.95198738
58layer formation in cerebral cortex (GO:0021819)2.94880684
59positive regulation of Rap GTPase activity (GO:0032854)2.93539496
60negative thymic T cell selection (GO:0045060)2.93235511
61regulation of B cell differentiation (GO:0045577)2.92422888
62maintenance of gastrointestinal epithelium (GO:0030277)2.92346755
63complement activation (GO:0006956)2.91990677
64establishment of protein localization to Golgi (GO:0072600)2.91473189
65neuron-neuron synaptic transmission (GO:0007270)2.90345584
66thymic T cell selection (GO:0045061)2.89031180
67positive regulation of respiratory burst (GO:0060267)2.88811404
68neurotransmitter-gated ion channel clustering (GO:0072578)2.87834276
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86913597
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.86599359
71antibacterial humoral response (GO:0019731)2.86311749
72retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84783153
73Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.84240638
74immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.84240638
75Fc-gamma receptor signaling pathway (GO:0038094)2.84240638
76axonal fasciculation (GO:0007413)2.83918477
77histone H3-K36 demethylation (GO:0070544)2.80010815
78Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.79878300
79regulation of antigen processing and presentation (GO:0002577)2.79874015
80regulation of cellular extravasation (GO:0002691)2.76095950
81protein localization to synapse (GO:0035418)2.75845803
82cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.75596665
83neuron recognition (GO:0008038)2.75461568
84antimicrobial humoral response (GO:0019730)2.75317582
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73879247
86regulation of gamma-delta T cell differentiation (GO:0045586)2.73492276
87T cell selection (GO:0045058)2.73091651
88interferon-gamma-mediated signaling pathway (GO:0060333)2.72733824
89mature B cell differentiation (GO:0002335)2.71273995
90regulation of RIG-I signaling pathway (GO:0039535)2.71212672
91detection of other organism (GO:0098543)2.70424409
92membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.69808734
93cerebellar Purkinje cell differentiation (GO:0021702)2.69607774
94detection of bacterium (GO:0016045)2.69313930
95relaxation of cardiac muscle (GO:0055119)2.69222455
96activation of Rac GTPase activity (GO:0032863)2.68753421
97positive regulation of cell adhesion mediated by integrin (GO:0033630)2.68721638
98production of molecular mediator involved in inflammatory response (GO:0002532)2.67665446
99negative T cell selection (GO:0043383)2.67445200
100hypotonic response (GO:0006971)2.66134906
101hormone catabolic process (GO:0042447)2.65777600
102chemical homeostasis within a tissue (GO:0048875)2.65174704
103regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.63410415
104exploration behavior (GO:0035640)2.61167356
105regulation of guanylate cyclase activity (GO:0031282)2.61064138
106T cell costimulation (GO:0031295)2.59957857
107maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59012032
108immune response-activating cell surface receptor signaling pathway (GO:0002429)2.58085464
109N-glycan processing (GO:0006491)2.57707522
110neurotransmitter transport (GO:0006836)2.57176414
111innervation (GO:0060384)2.55228477
112lymphocyte costimulation (GO:0031294)2.54825188
113long-term memory (GO:0007616)2.54641425
114regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.54608231
115positive regulation of neurotransmitter secretion (GO:0001956)2.54465282
116cellular response to type I interferon (GO:0071357)2.54200700
117type I interferon signaling pathway (GO:0060337)2.54200700
118regulation of gamma-delta T cell activation (GO:0046643)2.53883410
119negative regulation of hormone metabolic process (GO:0032351)2.53449087
120negative regulation of hormone biosynthetic process (GO:0032353)2.53449087
121response to type I interferon (GO:0034340)2.53249392
122epithelial structure maintenance (GO:0010669)2.52981521
123endothelial tube morphogenesis (GO:0061154)2.52649263
124morphogenesis of an endothelium (GO:0003159)2.52649263
125membrane hyperpolarization (GO:0060081)2.51286103
126positive regulation of Cdc42 GTPase activity (GO:0043089)2.50339623
127antigen receptor-mediated signaling pathway (GO:0050851)2.50313017
128angiotensin maturation (GO:0002003)2.49992382
129membrane repolarization during action potential (GO:0086011)2.49288737
130cell communication by electrical coupling (GO:0010644)2.49123896
131humoral immune response (GO:0006959)2.48428041
132long-term synaptic potentiation (GO:0060291)2.48079274
133long term synaptic depression (GO:0060292)2.47468378
134response to auditory stimulus (GO:0010996)2.47399919
135B cell mediated immunity (GO:0019724)2.47101980
136negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46608170
137regulation of neuronal synaptic plasticity (GO:0048168)2.46165217
138B cell homeostasis (GO:0001782)2.45840540
139regulation of postsynaptic membrane potential (GO:0060078)2.45051914
140intestinal absorption (GO:0050892)2.44961771
141cell communication involved in cardiac conduction (GO:0086065)2.44596638
142regulation of excitatory postsynaptic membrane potential (GO:0060079)2.44293476
143NIK/NF-kappaB signaling (GO:0038061)2.42497868
144negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.42157936
145regulation of Rap GTPase activity (GO:0032317)2.41791033
146prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.41015081
147production of molecular mediator of immune response (GO:0002440)2.40793582
148membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40637645
149macrophage activation involved in immune response (GO:0002281)2.40558864
150positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.40207376
151response to pheromone (GO:0019236)2.39796301
152alanine transport (GO:0032328)2.39767722
153negative regulation of protein localization to plasma membrane (GO:1903077)2.38644059
154negative regulation of glycoprotein biosynthetic process (GO:0010561)2.38445671
155positive regulation of pseudopodium assembly (GO:0031274)2.38066007
156cellular response to ethanol (GO:0071361)2.37827037
157Golgi transport vesicle coating (GO:0048200)2.36559676
158COPI coating of Golgi vesicle (GO:0048205)2.36559676
159hemidesmosome assembly (GO:0031581)2.35481815
160synaptic vesicle endocytosis (GO:0048488)2.35084053
161fucose metabolic process (GO:0006004)2.33546943
162midgut development (GO:0007494)2.33289908
163positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.33262255
164regulation of synapse maturation (GO:0090128)2.33256015
165cellular sodium ion homeostasis (GO:0006883)2.32780360
166protein localization to endosome (GO:0036010)2.32580536
167regulation of respiratory burst (GO:0060263)2.32398308
168phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.32386429
169regulation of long-term neuronal synaptic plasticity (GO:0048169)2.32327477
170response to laminar fluid shear stress (GO:0034616)2.32325618
171positive regulation of exocytosis (GO:0045921)2.32200089
172regulation of beta-amyloid formation (GO:1902003)2.31722575
173regulation of neurotransmitter secretion (GO:0046928)2.31377928
174positive T cell selection (GO:0043368)2.31296515
175regulation of synaptic plasticity (GO:0048167)2.30822940
176potassium ion import (GO:0010107)2.30791359
177membrane depolarization during action potential (GO:0086010)2.30546915
178regulation of chemokine secretion (GO:0090196)2.30206652
179establishment of endothelial barrier (GO:0061028)2.29745182
180regulation of ARF protein signal transduction (GO:0032012)2.27064141
181presynaptic membrane assembly (GO:0097105)2.26950580
182positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.26881770
183regulation of calcium ion-dependent exocytosis (GO:0017158)2.26804356
184regulation of neurotransmitter levels (GO:0001505)2.26602764
185cell differentiation in hindbrain (GO:0021533)2.25261722
186drug transmembrane transport (GO:0006855)2.24963457
187macroautophagy (GO:0016236)2.24950591
188cochlea development (GO:0090102)2.24859759
189positive regulation of type 2 immune response (GO:0002830)2.24720765
190postsynaptic membrane organization (GO:0001941)2.24359011
191negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.24023105
192negative regulation of T-helper cell differentiation (GO:0045623)2.24023105
193positive regulation by symbiont of host defense response (GO:0052509)2.23760385
194modulation by symbiont of host defense response (GO:0052031)2.23760385
195modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.23760385
196modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.23760385
197positive regulation by organism of defense response of other organism involved in symbiotic interact2.23760385
198modulation by symbiont of host immune response (GO:0052553)2.23760385
199inner ear receptor cell development (GO:0060119)2.22866022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.54836957
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.47427923
3EZH2_22144423_ChIP-Seq_EOC_Human3.72127203
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99650630
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.97139606
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.95326954
7GBX2_23144817_ChIP-Seq_PC3_Human2.86394679
8MYC_22102868_ChIP-Seq_BL_Human2.80393791
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74193955
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72399000
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.68536708
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55785755
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48521287
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46024656
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40341806
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.35842711
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27037533
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25998979
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25998979
20DROSHA_22980978_ChIP-Seq_HELA_Human2.23444391
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23411877
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17812120
23* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16575412
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14333375
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13555609
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12721474
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12635108
28* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12205829
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.10385541
30BP1_19119308_ChIP-ChIP_Hs578T_Human2.07203663
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07091361
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06107005
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.97641621
34* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97375646
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.97153494
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96032979
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.94360961
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93871053
39RUNX_20019798_ChIP-Seq_JUKART_Human1.93153212
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92453475
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.91862082
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.91539118
43* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.89913513
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86222165
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83614923
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82399173
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.82231854
48MYB_26560356_Chip-Seq_TH2_Human1.74567921
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73394633
50* RNF2_27304074_Chip-Seq_ESCs_Mouse1.73131806
51REST_21632747_ChIP-Seq_MESCs_Mouse1.72016095
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.70999401
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.69553906
54MYB_26560356_Chip-Seq_TH1_Human1.66125228
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62888659
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60897858
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.60856206
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57642631
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56651220
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.54949944
61SMAD4_21799915_ChIP-Seq_A2780_Human1.53785212
62* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53209934
63AHR_22903824_ChIP-Seq_MCF-7_Human1.53006847
64TCF7_22412390_ChIP-Seq_EML_Mouse1.52841401
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52592158
66GATA1_22025678_ChIP-Seq_K562_Human1.51887779
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50289749
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50289749
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46142200
70VDR_24763502_ChIP-Seq_THP-1_Human1.45068498
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43704849
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43304434
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42195480
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41469358
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41439825
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40261598
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.39845966
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.39745439
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38058015
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37967717
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37725492
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37563322
83GATA6_25053715_ChIP-Seq_YYC3_Human1.37300023
84MAF_26560356_Chip-Seq_TH1_Human1.35917209
85SPI1_23127762_ChIP-Seq_K562_Human1.35497527
86AR_25329375_ChIP-Seq_VCAP_Human1.34385569
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33558232
88CLOCK_20551151_ChIP-Seq_293T_Human1.33398862
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33200248
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32750704
91TAF15_26573619_Chip-Seq_HEK293_Human1.32605376
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32176706
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30699742
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29843023
95REST_18959480_ChIP-ChIP_MESCs_Mouse1.29060413
96* VDR_24787735_ChIP-Seq_THP-1_Human1.28768095
97VDR_21846776_ChIP-Seq_THP-1_Human1.28219360
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.27941207
99GATA4_25053715_ChIP-Seq_YYC3_Human1.26533634
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26138981
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24352323
102TP53_16413492_ChIP-PET_HCT116_Human1.23649647
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.23442930
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23107166
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22876043
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22778525
107TCF4_18268006_ChIP-ChIP_LS174T_Human1.22326817
108AR_21572438_ChIP-Seq_LNCaP_Human1.22176648
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20956326
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20940487
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20862475
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19749515
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19529441
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18950355
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18942257
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.18312716
117ELK3_25401928_ChIP-Seq_HUVEC_Human1.18068403
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.16537133
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16086875
120SCL_19346495_ChIP-Seq_HPC-7_Human1.15899015
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15585784
122ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15514448
123P300_19829295_ChIP-Seq_ESCs_Human1.14875219
124STAT3_23295773_ChIP-Seq_U87_Human1.14275967
125CBX2_27304074_Chip-Seq_ESCs_Mouse1.14133850
126POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12832753
127WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12350619
128AR_19668381_ChIP-Seq_PC3_Human1.11658010
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10425066
130RUNX1_27514584_Chip-Seq_MCF-7_Human1.09851592
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09758822
132GATA2_19941826_ChIP-Seq_K562_Human1.09454807
133BCAT_22108803_ChIP-Seq_LS180_Human1.09160870
134CDX2_20551321_ChIP-Seq_CACO-2_Human1.09139903
135TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08788608
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08363077
137UTX_26944678_Chip-Seq_JUKART_Human1.08334610
138GATA1_19941827_ChIP-Seq_MEL_Mouse1.08205497
139CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07109293
140RXR_22108803_ChIP-Seq_LS180_Human1.06647216
141SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06201447
142* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04902301
143P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04705372
144KLF5_25053715_ChIP-Seq_YYC3_Human1.04339386
145TP53_18474530_ChIP-ChIP_U2OS_Human1.04305269
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04058077
147YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03876149
148FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03789089
149* LXR_22158963_ChIP-Seq_LIVER_Mouse1.03428106
150IGF1R_20145208_ChIP-Seq_DFB_Human1.03424641
151KDM2B_26808549_Chip-Seq_DND41_Human1.03375173
152* ZNF274_21170338_ChIP-Seq_K562_Hela1.03288585
153SPI1_23547873_ChIP-Seq_NB4_Human1.02928427
154SMAD3_21741376_ChIP-Seq_HESCs_Human1.02916789
155TCF4_23295773_ChIP-Seq_U87_Human1.02903549
156PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02463683
157AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01449847
158RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01351504
159FOXA2_19822575_ChIP-Seq_HepG2_Human1.00896015
160GATA1_19941826_ChIP-Seq_K562_Human1.00441982
161ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99189201
162NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99188869
163* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99033452
164SMAD4_21741376_ChIP-Seq_HESCs_Human0.98659267
165RACK7_27058665_Chip-Seq_MCF-7_Human0.98425475
166TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98211882
167NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97764240
168NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97764240
169SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97318241
170P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96333591
171VDR_22108803_ChIP-Seq_LS180_Human0.95835341
172* RUNX2_22187159_ChIP-Seq_PCA_Human0.95784458
173RING1B_27294783_Chip-Seq_ESCs_Mouse0.95646732
174RING1B_27294783_Chip-Seq_NPCs_Mouse0.93476706
175ESR1_21235772_ChIP-Seq_MCF-7_Human0.93076031
176GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92357124
177GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91841258
178TP63_23658742_ChIP-Seq_EP156T_Human0.91423956
179SOX2_20726797_ChIP-Seq_SW620_Human0.90954610
180TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90640722
181FOXA1_25552417_ChIP-Seq_VCAP_Human0.90406620
182FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89854016
183NANOG_18555785_Chip-Seq_ESCs_Mouse0.89261147
184TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89116856
185SMAD_19615063_ChIP-ChIP_OVARY_Human0.89100524
186ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87614554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.90653008
2MP0010352_gastrointestinal_tract_polyps3.09778153
3MP0010234_abnormal_vibrissa_follicle3.04178455
4MP0009780_abnormal_chondrocyte_physiolo3.00926285
5MP0004043_abnormal_pH_regulation2.96077659
6MP0003303_peritoneal_inflammation2.96067100
7MP0001835_abnormal_antigen_presentation2.83788507
8MP0004270_analgesia2.77068877
9MP0003635_abnormal_synaptic_transmissio2.72879251
10MP0003880_abnormal_central_pattern2.60574003
11MP0010386_abnormal_urinary_bladder2.49722197
12MP0002876_abnormal_thyroid_physiology2.49296320
13MP0010155_abnormal_intestine_physiology2.47299749
14MP0000465_gastrointestinal_hemorrhage2.39693765
15MP0005310_abnormal_salivary_gland2.34621899
16MP0001800_abnormal_humoral_immune2.31884306
17MP0005387_immune_system_phenotype2.30350299
18MP0001790_abnormal_immune_system2.30350299
19MP0002734_abnormal_mechanical_nocicepti2.28784759
20MP0000685_abnormal_immune_system2.28561399
21MP0009046_muscle_twitch2.20410997
22MP0003763_abnormal_thymus_physiology2.20293674
23MP0003183_abnormal_peptide_metabolism2.19180876
24MP0009745_abnormal_behavioral_response2.15229343
25MP0003566_abnormal_cell_adhesion2.10152789
26MP0002063_abnormal_learning/memory/cond2.08870735
27MP0002064_seizures1.97214408
28MP0000678_abnormal_parathyroid_gland1.97015686
29MP0001968_abnormal_touch/_nociception1.95231950
30MP0001666_abnormal_nutrient_absorption1.93885777
31MP0003879_abnormal_hair_cell1.93679957
32MP0003436_decreased_susceptibility_to1.93597972
33MP0002139_abnormal_hepatobiliary_system1.91001777
34MP0001765_abnormal_ion_homeostasis1.90311711
35MP0003705_abnormal_hypodermis_morpholog1.85821187
36MP0002735_abnormal_chemical_nociception1.85722290
37MP0002452_abnormal_antigen_presenting1.84052277
38MP0002909_abnormal_adrenal_gland1.83603514
39MP0005647_abnormal_sex_gland1.83462066
40MP0002572_abnormal_emotion/affect_behav1.83384570
41MP0005000_abnormal_immune_tolerance1.79015000
42MP0009840_abnormal_foam_cell1.77767992
43MP0003091_abnormal_cell_migration1.76123081
44MP0002736_abnormal_nociception_after1.74501557
45MP0001664_abnormal_digestion1.73280644
46MP0005360_urolithiasis1.71390460
47MP0001501_abnormal_sleep_pattern1.69265397
48MP0001440_abnormal_grooming_behavior1.69141640
49MP0003300_gastrointestinal_ulcer1.68166133
50MP0001486_abnormal_startle_reflex1.68102328
51MP0004145_abnormal_muscle_electrophysio1.67411792
52MP0002272_abnormal_nervous_system1.63664561
53MP0003329_amyloid_beta_deposits1.62553467
54MP0002184_abnormal_innervation1.60778790
55MP0003283_abnormal_digestive_organ1.60547165
56MP0005423_abnormal_somatic_nervous1.57567201
57MP0002557_abnormal_social/conspecific_i1.57467120
58MP0010678_abnormal_skin_adnexa1.56621562
59MP0004782_abnormal_surfactant_physiolog1.55092729
60MP0002166_altered_tumor_susceptibility1.54786026
61MP0004264_abnormal_extraembryonic_tissu1.54763698
62MP0003724_increased_susceptibility_to1.53597214
63MP0002420_abnormal_adaptive_immunity1.51034676
64MP0004947_skin_inflammation1.49881093
65MP0001819_abnormal_immune_cell1.49025887
66MP0003453_abnormal_keratinocyte_physiol1.48466993
67MP0005025_abnormal_response_to1.47528246
68MP0004858_abnormal_nervous_system1.47327687
69MP0004885_abnormal_endolymph1.46641145
70MP0002723_abnormal_immune_serum1.46173207
71MP0000490_abnormal_crypts_of1.45277119
72MP0002067_abnormal_sensory_capabilities1.43366222
73MP0002396_abnormal_hematopoietic_system1.42910049
74MP0001970_abnormal_pain_threshold1.41666226
75MP0000538_abnormal_urinary_bladder1.41426655
76MP0002733_abnormal_thermal_nociception1.40737240
77MP0001873_stomach_inflammation1.40732630
78MP0005365_abnormal_bile_salt1.38684006
79MP0002254_reproductive_system_inflammat1.34002112
80MP0002009_preneoplasia1.29690706
81MP0008569_lethality_at_weaning1.28520159
82MP0005166_decreased_susceptibility_to1.28052650
83MP0001485_abnormal_pinna_reflex1.27583513
84MP0000537_abnormal_urethra_morphology1.27189682
85MP0004742_abnormal_vestibular_system1.26923933
86MP0003868_abnormal_feces_composition1.26693513
87MP0002398_abnormal_bone_marrow1.26234319
88MP0002419_abnormal_innate_immunity1.25876240
89MP0002006_tumorigenesis1.23891443
90MP0009785_altered_susceptibility_to1.23567720
91MP0003448_altered_tumor_morphology1.22999104
92MP0003045_fibrosis1.22537626
93MP0008004_abnormal_stomach_pH1.21830169
94MP0000716_abnormal_immune_system1.21516066
95MP0000858_altered_metastatic_potential1.21229503
96MP0000778_abnormal_nervous_system1.19277770
97MP0005409_darkened_coat_color1.17142119
98MP0002796_impaired_skin_barrier1.17035143
99MP0002822_catalepsy1.16681397
100MP0001845_abnormal_inflammatory_respons1.15363797
101MP0000477_abnormal_intestine_morphology1.15319842
102MP0008875_abnormal_xenobiotic_pharmacok1.14861606
103MP0003252_abnormal_bile_duct1.13967782
104MP0000604_amyloidosis1.12302583
105MP0003878_abnormal_ear_physiology1.11316834
106MP0005377_hearing/vestibular/ear_phenot1.11316834
107MP0005451_abnormal_body_composition1.10889282
108MP0005085_abnormal_gallbladder_physiolo1.10873984
109MP0005671_abnormal_response_to1.09485880
110MP0001502_abnormal_circadian_rhythm1.08177146
111MP0008057_abnormal_DNA_replication1.07501499
112MP0003195_calcinosis1.07171893
113MP0001849_ear_inflammation1.02074144
114MP0002405_respiratory_system_inflammati1.02045304
115MP0005023_abnormal_wound_healing1.00285297
116MP0005332_abnormal_amino_acid1.00105124
117MP0002098_abnormal_vibrissa_morphology0.99755018
118MP0000613_abnormal_salivary_gland0.99472302
119MP0005646_abnormal_pituitary_gland0.98853022
120MP0002429_abnormal_blood_cell0.98814032
121MP0005636_abnormal_mineral_homeostasis0.98486803
122MP0010368_abnormal_lymphatic_system0.98388414
123MP0004147_increased_porphyrin_level0.97881068
124MP0000689_abnormal_spleen_morphology0.97580998
125MP0000462_abnormal_digestive_system0.96512323
126MP0002148_abnormal_hypersensitivity_rea0.95981458
127MP0000955_abnormal_spinal_cord0.95567090
128MP0001851_eye_inflammation0.95323073
129MP0000249_abnormal_blood_vessel0.92056026
130MP0004808_abnormal_hematopoietic_stem0.91961521
131MP0003866_abnormal_defecation0.91287419
132MP0005464_abnormal_platelet_physiology0.91125458
133MP0002837_dystrophic_cardiac_calcinosis0.90474791
134MP0002066_abnormal_motor_capabilities/c0.90007699
135MP0002722_abnormal_immune_system0.89969933
136MP0002069_abnormal_eating/drinking_beha0.89513765
137MP0001756_abnormal_urination0.89035185
138MP0002136_abnormal_kidney_physiology0.88384579
139MP0008260_abnormal_autophagy0.87117229
140MP0000681_abnormal_thyroid_gland0.86853122
141MP0004272_abnormal_basement_membrane0.86063564
142MP0005187_abnormal_penis_morphology0.85586751
143MP0004484_altered_response_of0.84939795
144MP0004924_abnormal_behavior0.84240205
145MP0005386_behavior/neurological_phenoty0.84240205
146MP0005220_abnormal_exocrine_pancreas0.83528125
147MP0001216_abnormal_epidermal_layer0.83521853
148MP0001533_abnormal_skeleton_physiology0.83295480
149MP0000751_myopathy0.83220366
150MP0002882_abnormal_neuron_morphology0.83083320
151MP0005501_abnormal_skin_physiology0.82507576
152MP0001879_abnormal_lymphatic_vessel0.79859220
153MP0005645_abnormal_hypothalamus_physiol0.79440630
154MP0002877_abnormal_melanocyte_morpholog0.78890060
155MP0005076_abnormal_cell_differentiation0.78865389
156MP0005621_abnormal_cell_physiology0.78735455
157MP0001663_abnormal_digestive_system0.78343233
158MP0003633_abnormal_nervous_system0.78330326
159MP0004811_abnormal_neuron_physiology0.76850324
160MP0001958_emphysema0.76568599
161MP0005381_digestive/alimentary_phenotyp0.76192678
162MP0010329_abnormal_lipoprotein_level0.75324892
163MP0003172_abnormal_lysosome_physiology0.74309691
164MP0002998_abnormal_bone_remodeling0.74061997
165MP0005388_respiratory_system_phenotype0.74047223
166MP0002133_abnormal_respiratory_system0.74047223
167MP0000569_abnormal_digit_pigmentation0.73650964
168MP0002138_abnormal_hepatobiliary_system0.73570975
169MP0005535_abnormal_body_temperature0.73454095
170MP0001944_abnormal_pancreas_morphology0.72745728
171MP0001963_abnormal_hearing_physiology0.72360474
172MP0006082_CNS_inflammation0.72231711
173MP0010307_abnormal_tumor_latency0.71469465
174MP0009643_abnormal_urine_homeostasis0.71259222
175MP0004019_abnormal_vitamin_homeostasis0.70605293
176MP0002896_abnormal_bone_mineralization0.70153667

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.77362782
2Agammaglobulinemia (HP:0004432)4.58918379
3Atonic seizures (HP:0010819)4.45493919
4Focal seizures (HP:0007359)4.45026323
5Febrile seizures (HP:0002373)4.26483737
6Gastrointestinal stroma tumor (HP:0100723)4.11967920
7Epileptic encephalopathy (HP:0200134)4.04079447
8Recurrent bronchitis (HP:0002837)4.02537072
9Visual hallucinations (HP:0002367)3.83732293
10Hyperventilation (HP:0002883)3.80919061
11Absence seizures (HP:0002121)3.70052122
12Cellulitis (HP:0100658)3.50873459
13Recurrent sinusitis (HP:0011108)3.44891581
14Colitis (HP:0002583)3.44069939
15Flat acetabular roof (HP:0003180)3.41872679
16Eczematoid dermatitis (HP:0000976)3.29793793
17Chronic diarrhea (HP:0002028)3.23063935
18Emphysema (HP:0002097)3.20407073
19Malnutrition (HP:0004395)3.20226279
20Generalized tonic-clonic seizures (HP:0002069)3.13907517
21Dialeptic seizures (HP:0011146)3.12790807
22Abnormality of cochlea (HP:0000375)3.10678892
23Abnormality of small intestinal villus morphology (HP:0011472)3.10600021
24Villous atrophy (HP:0011473)3.10600021
25Bronchitis (HP:0012387)3.05319038
26Vertebral arch anomaly (HP:0008438)3.03929749
27Action tremor (HP:0002345)3.02048141
28Progressive cerebellar ataxia (HP:0002073)2.97248006
29Gaze-evoked nystagmus (HP:0000640)2.88970461
30Viral hepatitis (HP:0006562)2.87572798
31Status epilepticus (HP:0002133)2.86523079
32Chronic otitis media (HP:0000389)2.86273505
33Myokymia (HP:0002411)2.84630363
34Vasculitis (HP:0002633)2.79729396
35Broad-based gait (HP:0002136)2.79178061
36Osteomyelitis (HP:0002754)2.79054432
37Recurrent pneumonia (HP:0006532)2.74421335
38Subacute progressive viral hepatitis (HP:0006572)2.74139720
39Ankle clonus (HP:0011448)2.73827941
40Gastrointestinal inflammation (HP:0004386)2.70455132
41Hyperactive renin-angiotensin system (HP:0000841)2.68976654
42Metabolic alkalosis (HP:0200114)2.68380379
43Inflammation of the large intestine (HP:0002037)2.68341105
44Abnormality of cells of the lymphoid lineage (HP:0012140)2.66817888
45Meningitis (HP:0001287)2.64678640
46Restrictive lung disease (HP:0002091)2.61996030
47Impaired social interactions (HP:0000735)2.58038464
48Abnormal social behavior (HP:0012433)2.58038464
49Potter facies (HP:0002009)2.57714601
50Facial shape deformation (HP:0011334)2.57714601
51Lymphopenia (HP:0001888)2.57287505
52Spontaneous hematomas (HP:0007420)2.56884383
53Arterial tortuosity (HP:0005116)2.52262094
54Abnormality of the nasal mucosa (HP:0000433)2.50502113
55Recurrent viral infections (HP:0004429)2.46715090
56Hyperphosphatemia (HP:0002905)2.46418807
57Dysmetric saccades (HP:0000641)2.44471218
58Poor eye contact (HP:0000817)2.44367357
59Conjugated hyperbilirubinemia (HP:0002908)2.42402274
60Recurrent otitis media (HP:0000403)2.41982355
61Papilloma (HP:0012740)2.41366174
62Verrucae (HP:0200043)2.41366174
63Agitation (HP:0000713)2.40842706
64Thoracic kyphosis (HP:0002942)2.40722479
65Abnormality of chloride homeostasis (HP:0011422)2.39215726
66Hemiplegia (HP:0002301)2.36397966
67Gout (HP:0001997)2.35094320
68Abnormality of the lumbar spine (HP:0100712)2.33794910
69Hypomagnesemia (HP:0002917)2.33127072
70Epileptiform EEG discharges (HP:0011182)2.33091010
71Impaired vibration sensation in the lower limbs (HP:0002166)2.33029697
72Urinary bladder sphincter dysfunction (HP:0002839)2.30629163
73Abnormal delayed hypersensitivity skin test (HP:0002963)2.30240821
74Right ventricular cardiomyopathy (HP:0011663)2.29796509
75Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28275987
76Nasal polyposis (HP:0100582)2.26699690
77Recurrent lower respiratory tract infections (HP:0002783)2.26648069
78Curly hair (HP:0002212)2.26445600
79Hypoplasia of the uterus (HP:0000013)2.26016956
80Interstitial pulmonary disease (HP:0006530)2.23654876
81Gingivitis (HP:0000230)2.23111404
82Abnormality of the thoracic spine (HP:0100711)2.23002667
83EEG with generalized epileptiform discharges (HP:0011198)2.22018583
84Chronic sinusitis (HP:0011109)2.21751871
85Excessive salivation (HP:0003781)2.21422912
86Drooling (HP:0002307)2.21422912
87Intention tremor (HP:0002080)2.20213440
88Absent speech (HP:0001344)2.19861554
89Carpal bone hypoplasia (HP:0001498)2.19498011
90Hypoplastic nipples (HP:0002557)2.19211461
91Aplasia involving bones of the upper limbs (HP:0009823)2.18481500
92Aplasia of the phalanges of the hand (HP:0009802)2.18481500
93Aplasia involving bones of the extremities (HP:0009825)2.18481500
94Truncal ataxia (HP:0002078)2.16737202
95Abnormality of the corticospinal tract (HP:0002492)2.14876667
96Dysdiadochokinesis (HP:0002075)2.14132542
97Aortic regurgitation (HP:0001659)2.13148172
98Ketoacidosis (HP:0001993)2.11109035
99Thickened calvaria (HP:0002684)2.08321256
100Vascular tortuosity (HP:0004948)2.07588270
101Symphalangism affecting the phalanges of the hand (HP:0009773)2.05996687
102Protruding tongue (HP:0010808)2.05862197
103Supranuclear gaze palsy (HP:0000605)2.05558504
104IgA deficiency (HP:0002720)2.04993936
105Hypsarrhythmia (HP:0002521)2.03337856
106J-shaped sella turcica (HP:0002680)2.03100575
107Abnormality of monocarboxylic acid metabolism (HP:0010996)2.03014674
108Recurrent bacterial skin infections (HP:0005406)2.02613540
109Abnormality of magnesium homeostasis (HP:0004921)2.01757165
110Cerebral inclusion bodies (HP:0100314)2.00362760
111Dysmetria (HP:0001310)1.99854922
112Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.99835156
113Amblyopia (HP:0000646)1.99109557
114Hepatitis (HP:0012115)1.98941220
115Abnormality of glutamine family amino acid metabolism (HP:0010902)1.97859366
116Ankyloglossia (HP:0010296)1.97441385
117Urinary glycosaminoglycan excretion (HP:0003541)1.97260505
118Mucopolysacchariduria (HP:0008155)1.97260505
119Nephritis (HP:0000123)1.97207554
120Bronchiectasis (HP:0002110)1.95619517
121Thoracolumbar scoliosis (HP:0002944)1.95613869
122Syncope (HP:0001279)1.95414794
123Recurrent abscess formation (HP:0002722)1.95346785
124Hand muscle atrophy (HP:0009130)1.95281592
125Ventricular fibrillation (HP:0001663)1.95081972
126Impaired smooth pursuit (HP:0007772)1.94953192
127Stereotypic behavior (HP:0000733)1.94124670
128Abnormal hair laboratory examination (HP:0003328)1.93911859
129Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92986037
130Abnormality of polysaccharide metabolism (HP:0011012)1.92986037
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92986037
132Dehydration (HP:0001944)1.92597043
133Mediastinal lymphadenopathy (HP:0100721)1.91080269
134IgM deficiency (HP:0002850)1.90913413
135Milia (HP:0001056)1.90700189
136Abnormality of renin-angiotensin system (HP:0000847)1.90518784
137Hypokalemia (HP:0002900)1.90239933
138Chest pain (HP:0100749)1.89563830
139Abnormality of the fingertips (HP:0001211)1.89183464
140Exocrine pancreatic insufficiency (HP:0001738)1.89143649
141Sepsis (HP:0100806)1.87623449
142Confusion (HP:0001289)1.87599494
143Genetic anticipation (HP:0003743)1.87098554
144Hemiparesis (HP:0001269)1.86845759
145Abnormality of potassium homeostasis (HP:0011042)1.86270284
146Bundle branch block (HP:0011710)1.85289924
147Increased circulating renin level (HP:0000848)1.85018228
148Sensorimotor neuropathy (HP:0007141)1.83078184
149Morphological abnormality of the inner ear (HP:0011390)1.82694830
150Myopathic facies (HP:0002058)1.81375843
151Skin rash (HP:0000988)1.81359995
152Systemic lupus erythematosus (HP:0002725)1.80982991
153Abnormality of the distal phalanx of the thumb (HP:0009617)1.80745226
154Male infertility (HP:0003251)1.80523065
155Hydroxyprolinuria (HP:0003080)1.78709686
156Abnormality of proline metabolism (HP:0010907)1.78709686
157Abnormal platelet volume (HP:0011876)1.78596565
158Abnormality of macrophages (HP:0004311)1.78536942
159Decreased circulating renin level (HP:0003351)1.78006133
160Scanning speech (HP:0002168)1.77448133
161Abdominal distention (HP:0003270)1.77265960
162Exercise-induced myalgia (HP:0003738)1.76538586
163Obstructive lung disease (HP:0006536)1.75420199
164Chronic obstructive pulmonary disease (HP:0006510)1.75420199
165Exotropia (HP:0000577)1.74408821
166Pustule (HP:0200039)1.74141605
167Abnormality of oral frenula (HP:0000190)1.73716789
168Hematochezia (HP:0002573)1.73698843
169Increased IgE level (HP:0003212)1.73012107
170Widely patent fontanelles and sutures (HP:0004492)1.72895036
171Depression (HP:0000716)1.72561219
172Impaired vibratory sensation (HP:0002495)1.72029893
173Anosmia (HP:0000458)1.71793571
174Blue irides (HP:0000635)1.71580884
175Neonatal short-limb short stature (HP:0008921)1.70555179
176Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.70456466
177Spastic gait (HP:0002064)1.69660965
178Abnormality of binocular vision (HP:0011514)1.69605677
179Diplopia (HP:0000651)1.69605677
180Fat malabsorption (HP:0002630)1.69576044
181Abnormality of calcium-phosphate metabolism (HP:0100530)1.69554184
182Glomerulonephritis (HP:0000099)1.69008424
183Recurrent fungal infections (HP:0002841)1.68293777
184Periodontitis (HP:0000704)1.67676923
185Aortic dissection (HP:0002647)1.65979786
186Panhypogammaglobulinemia (HP:0003139)1.64964643
187Abnormal biliary tract morphology (HP:0012440)1.64677447
188Increased mean platelet volume (HP:0011877)1.64408993
189Chronic bronchitis (HP:0004469)1.63910988
190Recurrent gram-negative bacterial infections (HP:0005420)1.63335207
191Skin ulcer (HP:0200042)1.62455679
192Abnormality of complement system (HP:0005339)1.62441284
193Hemorrhage of the eye (HP:0011885)1.61977140
194Pulmonary infiltrates (HP:0002113)1.61377328
195Visceral angiomatosis (HP:0100761)1.59959781
196Recurrent cutaneous fungal infections (HP:0011370)1.59410242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.66403396
2MAP3K103.64081874
3MAP4K13.35861863
4FRK3.32403562
5NTRK33.16342765
6DAPK22.85249687
7MAP3K42.75527598
8EPHA42.70082853
9CASK2.50694266
10TYK22.42598314
11OXSR12.40164096
12PRPF4B2.25565545
13MAP2K72.23599061
14MAP3K132.15819628
15LMTK22.10473636
16MAP3K22.03971650
17MAP2K42.03357099
18FGFR42.02573772
19MAP3K142.00136748
20STK391.89635436
21MAP3K91.88355620
22YES11.83311276
23TAOK31.80225819
24INSRR1.79273331
25MET1.74495485
26RIPK11.73931947
27RIPK41.73430137
28MST41.73362343
29SCYL21.73055114
30BTK1.55610813
31MARK11.55578375
32MINK11.55065672
33SMG11.54503821
34BLK1.52788801
35FGFR31.49735845
36ERN11.48466169
37TEC1.47853729
38JAK11.45461913
39LATS11.36900411
40NTRK11.36470855
41IRAK41.33205231
42CAMKK11.32756267
43KSR21.29869141
44FER1.26784959
45JAK31.25201112
46CAMKK21.24778228
47CSF1R1.24403747
48NTRK21.24121741
49MST1R1.24067437
50STK381.19707900
51NME11.14957587
52PAK61.13411909
53TRIB31.11894571
54PHKG11.11715519
55PHKG21.11715519
56SYK1.11490919
57DAPK11.11064161
58MAP3K121.07046597
59TIE11.03772164
60CSK1.02247389
61ITK1.01396512
62MAP3K71.01239869
63KSR11.00419176
64PTK60.98803133
65WNK40.98397545
66PAK40.98309196
67NEK90.95872647
68PRKG20.95402895
69WNK30.95267995
70IRAK30.94031554
71CDK50.93495902
72SGK20.92537386
73ACVR1B0.92028989
74IKBKE0.91225543
75IRAK10.91176731
76SGK2230.88840625
77SGK4940.88840625
78ZAP700.88807086
79EPHB10.88609680
80PLK20.88059980
81MAPK130.87792022
82PDGFRA0.87385189
83EPHA30.87015142
84SGK30.86368331
85LYN0.86004081
86FES0.85674341
87SIK30.84399810
88TBK10.83814793
89HCK0.83686792
90TNK20.83569107
91PIK3CA0.83134778
92STK100.82779811
93MAP3K80.82281699
94WNK10.78609410
95HIPK20.78282259
96CDK60.76536086
97STK240.73780807
98PIK3CG0.73669211
99GRK50.72999438
100PRKCG0.72769752
101CDK120.72197368
102DMPK0.72180908
103PRKD30.70723192
104RET0.68533129
105PASK0.67731890
106CAMK2B0.66106434
107SIK10.65774909
108BMPR20.65594979
109BRSK20.65574527
110MYLK0.65371584
111BCKDK0.65305715
112CAMK2A0.64380586
113TNIK0.64319054
114SGK10.64060882
115MAPK70.63366027
116NUAK10.62871249
117PAK30.62839652
118BMX0.62533957
119TYRO30.62168853
120NLK0.60245238
121STK110.60218264
122PRKCE0.59531881
123MAP2K10.59191369
124MAP3K10.59116362
125CDC42BPA0.58798141
126EPHA20.57269878
127CDK190.57264110
128PTK20.56539256
129MAPK110.56449380
130PRKCQ0.56243568
131RPS6KA20.55453614
132ERBB40.54847255
133PDPK10.53988602
134CAMK2G0.53597257
135BRD40.52380079
136CAMK2D0.52282951
137LCK0.50263092
138CAMK1G0.49375212
139PRKCH0.49335777
140PRKCI0.48632633
141EEF2K0.47751735
142LRRK20.46701280
143MELK0.46217677
144ABL10.45687204
145EIF2AK30.45511469
146PDK10.44629037
147ROCK20.44473220
148JAK20.44216914
149MARK20.44088336
150CAMK10.43110688
151GRK60.42847842
152CLK10.42799962
153PRKAA10.42245689
154MAP2K20.41890658
155FGR0.41859381
156PDGFRB0.41362647
157DYRK1A0.40278754
158MAP2K60.40013674
159TGFBR20.39728564
160FYN0.39171373
161PNCK0.38795590
162CCNB10.38369123
163PRKCZ0.36281469
164CDK40.36206885
165NEK60.35980091
166RPS6KA30.35837451
167PRKCA0.35067279
168EPHB20.35025445

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.72304424
2B cell receptor signaling pathway_Homo sapiens_hsa046622.63916021
3Allograft rejection_Homo sapiens_hsa053302.56734114
4Autoimmune thyroid disease_Homo sapiens_hsa053202.48210928
5Asthma_Homo sapiens_hsa053102.45847117
6Synaptic vesicle cycle_Homo sapiens_hsa047212.35737830
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.32714983
8Graft-versus-host disease_Homo sapiens_hsa053322.32412385
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24487348
10Sulfur metabolism_Homo sapiens_hsa009202.06397769
11Leishmaniasis_Homo sapiens_hsa051402.02892486
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99588450
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93561334
14Salivary secretion_Homo sapiens_hsa049701.93448417
15Primary immunodeficiency_Homo sapiens_hsa053401.91355440
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90381265
17Staphylococcus aureus infection_Homo sapiens_hsa051501.89716872
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84751441
19Long-term potentiation_Homo sapiens_hsa047201.81945615
20Insulin secretion_Homo sapiens_hsa049111.78484035
21Type I diabetes mellitus_Homo sapiens_hsa049401.77481021
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77475988
23Gastric acid secretion_Homo sapiens_hsa049711.75377792
24Circadian entrainment_Homo sapiens_hsa047131.75234500
25Pancreatic secretion_Homo sapiens_hsa049721.74998146
26Glutamatergic synapse_Homo sapiens_hsa047241.74362705
27GABAergic synapse_Homo sapiens_hsa047271.73963013
28Viral myocarditis_Homo sapiens_hsa054161.73355949
29Antigen processing and presentation_Homo sapiens_hsa046121.67103716
30Taste transduction_Homo sapiens_hsa047421.63071273
31Amphetamine addiction_Homo sapiens_hsa050311.55000953
32Toxoplasmosis_Homo sapiens_hsa051451.54108764
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52965716
34Collecting duct acid secretion_Homo sapiens_hsa049661.52619143
35Morphine addiction_Homo sapiens_hsa050321.51285626
36Mineral absorption_Homo sapiens_hsa049781.45530086
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45048002
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.39329683
39Bile secretion_Homo sapiens_hsa049761.37564218
40Influenza A_Homo sapiens_hsa051641.37153484
41Thyroid hormone synthesis_Homo sapiens_hsa049181.31340881
42Vibrio cholerae infection_Homo sapiens_hsa051101.29562469
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28544813
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27421766
45Renin secretion_Homo sapiens_hsa049241.26598054
46Olfactory transduction_Homo sapiens_hsa047401.25416205
47Hematopoietic cell lineage_Homo sapiens_hsa046401.25321512
48Chronic myeloid leukemia_Homo sapiens_hsa052201.24709602
49Long-term depression_Homo sapiens_hsa047301.22261234
50Dopaminergic synapse_Homo sapiens_hsa047281.21560594
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.21427738
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.20727760
53Osteoclast differentiation_Homo sapiens_hsa043801.17756568
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14670474
55Pancreatic cancer_Homo sapiens_hsa052121.13456046
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13410589
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12397336
58Type II diabetes mellitus_Homo sapiens_hsa049301.11978689
59Calcium signaling pathway_Homo sapiens_hsa040201.11581123
60Hepatitis C_Homo sapiens_hsa051601.09199178
61Arginine biosynthesis_Homo sapiens_hsa002201.08946212
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08943403
63Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06953961
64Cholinergic synapse_Homo sapiens_hsa047251.06435274
65Tuberculosis_Homo sapiens_hsa051521.04467624
66Oxytocin signaling pathway_Homo sapiens_hsa049211.03678480
67Nitrogen metabolism_Homo sapiens_hsa009101.02500007
68Renal cell carcinoma_Homo sapiens_hsa052111.01555872
69T cell receptor signaling pathway_Homo sapiens_hsa046601.00667714
70Renin-angiotensin system_Homo sapiens_hsa046141.00154972
71Protein digestion and absorption_Homo sapiens_hsa049740.99029562
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98525547
73GnRH signaling pathway_Homo sapiens_hsa049120.97820332
74Serotonergic synapse_Homo sapiens_hsa047260.95927786
75Herpes simplex infection_Homo sapiens_hsa051680.95117809
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94512641
77Fat digestion and absorption_Homo sapiens_hsa049750.94391548
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91526821
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90799725
80Small cell lung cancer_Homo sapiens_hsa052220.89173894
81Non-small cell lung cancer_Homo sapiens_hsa052230.88893753
82Measles_Homo sapiens_hsa051620.88834424
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.85673008
84cAMP signaling pathway_Homo sapiens_hsa040240.85437307
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84902829
86Adherens junction_Homo sapiens_hsa045200.83350616
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83063622
88Gap junction_Homo sapiens_hsa045400.82720911
89Acute myeloid leukemia_Homo sapiens_hsa052210.82230966
90TNF signaling pathway_Homo sapiens_hsa046680.81845750
91Prostate cancer_Homo sapiens_hsa052150.81594730
92Notch signaling pathway_Homo sapiens_hsa043300.81544251
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80531970
94Inositol phosphate metabolism_Homo sapiens_hsa005620.80446135
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79306177
96Hepatitis B_Homo sapiens_hsa051610.78784915
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78576016
98Estrogen signaling pathway_Homo sapiens_hsa049150.78247475
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76792257
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75989374
101Chemokine signaling pathway_Homo sapiens_hsa040620.75762847
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74176315
103Cocaine addiction_Homo sapiens_hsa050300.73755600
104HTLV-I infection_Homo sapiens_hsa051660.71547432
105Platelet activation_Homo sapiens_hsa046110.71483848
106Focal adhesion_Homo sapiens_hsa045100.71240006
107ErbB signaling pathway_Homo sapiens_hsa040120.70641084
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69734652
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65430546
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.65203714
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64621018
112Butanoate metabolism_Homo sapiens_hsa006500.64604712
113Apoptosis_Homo sapiens_hsa042100.63140235
114Vitamin digestion and absorption_Homo sapiens_hsa049770.62960892
115Thyroid cancer_Homo sapiens_hsa052160.62883953
116Sphingolipid metabolism_Homo sapiens_hsa006000.62381181
117Choline metabolism in cancer_Homo sapiens_hsa052310.62246254
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62136260
119Starch and sucrose metabolism_Homo sapiens_hsa005000.61447001
120Retinol metabolism_Homo sapiens_hsa008300.59765559
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59696110
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58381298
123Other glycan degradation_Homo sapiens_hsa005110.57997429
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.57993892
125Proteoglycans in cancer_Homo sapiens_hsa052050.57569285
126VEGF signaling pathway_Homo sapiens_hsa043700.57516358
127Glioma_Homo sapiens_hsa052140.57076383
128Melanogenesis_Homo sapiens_hsa049160.56433773
129Viral carcinogenesis_Homo sapiens_hsa052030.56367609
130Circadian rhythm_Homo sapiens_hsa047100.56188072
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55153073
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54675111
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.54308065
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53906655
135ABC transporters_Homo sapiens_hsa020100.53481583
136Endometrial cancer_Homo sapiens_hsa052130.53224204
137Fructose and mannose metabolism_Homo sapiens_hsa000510.53166336
138Pertussis_Homo sapiens_hsa051330.53088296
139Galactose metabolism_Homo sapiens_hsa000520.52936666
140Phagosome_Homo sapiens_hsa041450.52391472
141Glycerolipid metabolism_Homo sapiens_hsa005610.52080754
142Axon guidance_Homo sapiens_hsa043600.51523436
143Prolactin signaling pathway_Homo sapiens_hsa049170.50973073
144Dorso-ventral axis formation_Homo sapiens_hsa043200.50232279
145Tight junction_Homo sapiens_hsa045300.50024971
146RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49314003
147MicroRNAs in cancer_Homo sapiens_hsa052060.49018447
1482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48170962
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.47286994
150Systemic lupus erythematosus_Homo sapiens_hsa053220.46633462
151Fatty acid degradation_Homo sapiens_hsa000710.46503579
152Glucagon signaling pathway_Homo sapiens_hsa049220.45317104
153N-Glycan biosynthesis_Homo sapiens_hsa005100.45074732
154Caffeine metabolism_Homo sapiens_hsa002320.44660399
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44640527
156Fatty acid biosynthesis_Homo sapiens_hsa000610.43730803
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43561659
158Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43374939
159Colorectal cancer_Homo sapiens_hsa052100.42959646
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.42044939
161Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41358627
162Phospholipase D signaling pathway_Homo sapiens_hsa040720.40134186
163Dilated cardiomyopathy_Homo sapiens_hsa054140.37419237
164Amoebiasis_Homo sapiens_hsa051460.34254565
165Tryptophan metabolism_Homo sapiens_hsa003800.34117609
166Ovarian steroidogenesis_Homo sapiens_hsa049130.32823221
167Propanoate metabolism_Homo sapiens_hsa006400.32671909
168Histidine metabolism_Homo sapiens_hsa003400.32230451
169Pyruvate metabolism_Homo sapiens_hsa006200.32217229
170Insulin resistance_Homo sapiens_hsa049310.32147085

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