SELE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymphangiogenesis (GO:0001946)8.33880852
2vascular endothelial growth factor signaling pathway (GO:0038084)8.11830758
3cellular response to vascular endothelial growth factor stimulus (GO:0035924)6.93265626
4negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)6.78224617
5transcytosis (GO:0045056)6.60353620
6regulation of interleukin-12 biosynthetic process (GO:0045075)6.43700569
7interleukin-6-mediated signaling pathway (GO:0070102)6.38226484
8adhesion of symbiont to host (GO:0044406)6.10612547
9endothelium development (GO:0003158)5.97609182
10glomerular filtration (GO:0003094)5.84068920
11endothelial cell chemotaxis (GO:0035767)5.59414162
12renal filtration (GO:0097205)5.31663380
13positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)5.28385504
14retina vasculature morphogenesis in camera-type eye (GO:0061299)5.16590865
15cellular response to nicotine (GO:0071316)5.16394883
16negative regulation of inclusion body assembly (GO:0090084)5.11293396
17endothelial tube morphogenesis (GO:0061154)5.01468676
18morphogenesis of an endothelium (GO:0003159)5.01468676
19positive regulation of astrocyte differentiation (GO:0048711)4.99164531
20establishment of endothelial barrier (GO:0061028)4.94952573
21vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.92179520
22regulation of integrin activation (GO:0033623)4.80830340
23blood vessel maturation (GO:0001955)4.74940223
24protein kinase C signaling (GO:0070528)4.73337391
25positive regulation of vasculogenesis (GO:2001214)4.65791170
26regulation of cellular extravasation (GO:0002691)4.64704553
27blood vessel endothelial cell migration (GO:0043534)4.62235037
28positive regulation of p38MAPK cascade (GO:1900745)4.57989384
29response to muramyl dipeptide (GO:0032495)4.57191838
30regulation of cell migration involved in sprouting angiogenesis (GO:0090049)4.51171511
31ovulation from ovarian follicle (GO:0001542)4.48707558
32negative regulation of blood vessel endothelial cell migration (GO:0043537)4.45273908
33negative regulation of protein autophosphorylation (GO:0031953)4.44229628
34positive regulation of protein kinase C signaling (GO:0090037)4.37371147
35* leukocyte tethering or rolling (GO:0050901)4.26357856
36negative regulation of actin filament bundle assembly (GO:0032232)4.24042052
37adhesion of symbiont to host cell (GO:0044650)4.19148785
38virion attachment to host cell (GO:0019062)4.19148785
39endothelial cell morphogenesis (GO:0001886)4.16663989
40sprouting angiogenesis (GO:0002040)4.02629617
41regulation of p38MAPK cascade (GO:1900744)3.97321083
42negative regulation of endothelial cell migration (GO:0010596)3.91237745
43regulation of endothelial cell differentiation (GO:0045601)3.81427593
44positive regulation vascular endothelial growth factor production (GO:0010575)3.78143837
45negative regulation of platelet activation (GO:0010544)3.77872109
46potassium ion import (GO:0010107)3.77402090
47positive regulation of endothelial cell differentiation (GO:0045603)3.75280821
48negative regulation of endothelial cell apoptotic process (GO:2000352)3.69831645
49venous blood vessel morphogenesis (GO:0048845)3.67588217
50cell adhesion mediated by integrin (GO:0033627)3.65734383
51endothelial cell differentiation (GO:0045446)3.62598623
52response to interleukin-6 (GO:0070741)3.61147821
53regulation of vasculogenesis (GO:2001212)3.54318297
54regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.54142162
55regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.52340951
56regulation of platelet activation (GO:0010543)3.51053703
57cellular hyperosmotic response (GO:0071474)3.50818259
58surfactant homeostasis (GO:0043129)3.47885957
59cell migration involved in sprouting angiogenesis (GO:0002042)3.47059066
60positive regulation of digestive system process (GO:0060456)3.46114163
61patterning of blood vessels (GO:0001569)3.45597363
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.39703652
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.39703652
64negative regulation of nitric-oxide synthase activity (GO:0051001)3.39364432
65cellular response to nitric oxide (GO:0071732)3.39067688
66neuron remodeling (GO:0016322)3.38760987
67positive regulation of Rap GTPase activity (GO:0032854)3.38069659
68sexual reproduction (GO:0019953)3.37955364
69regulation of endothelial cell migration (GO:0010594)3.37942790
70phagocytosis, recognition (GO:0006910)3.37503967
71substrate-dependent cell migration (GO:0006929)3.37492233
72wound healing, spreading of epidermal cells (GO:0035313)3.35064363
73positive regulation of chondrocyte differentiation (GO:0032332)3.34375544
74heart trabecula morphogenesis (GO:0061384)3.30749024
75peptidyl-tyrosine autophosphorylation (GO:0038083)3.29453980
76positive regulation of endothelial cell apoptotic process (GO:2000353)3.29320544
77endothelial cell development (GO:0001885)3.29294494
78positive regulation of cardiac muscle hypertrophy (GO:0010613)3.29247254
79positive regulation of muscle hypertrophy (GO:0014742)3.29247254
80positive regulation of endothelial cell migration (GO:0010595)3.28590707
81Notch signaling involved in heart development (GO:0061314)3.28495484
82axon extension involved in axon guidance (GO:0048846)3.27824415
83neuron projection extension involved in neuron projection guidance (GO:1902284)3.27824415
84negative regulation of epithelial cell migration (GO:0010633)3.27624527
85mRNA transcription from RNA polymerase II promoter (GO:0042789)3.25096362
86heart trabecula formation (GO:0060347)3.24811990
87endocrine hormone secretion (GO:0060986)3.24446182
88cellular response to interleukin-6 (GO:0071354)3.23714050
89angiogenesis involved in wound healing (GO:0060055)3.23378846
90positive regulation of odontogenesis (GO:0042482)3.22268205
91positive regulation of endothelial cell proliferation (GO:0001938)3.20805359
92regulation of cholesterol storage (GO:0010885)3.19461643
93vasculogenesis (GO:0001570)3.15318157
94regulation of vascular endothelial growth factor production (GO:0010574)3.14777791
95negative regulation of stress fiber assembly (GO:0051497)3.14686312
96endothelial cell migration (GO:0043542)3.14468088
97positive regulation of hemostasis (GO:1900048)3.14375204
98positive regulation of blood coagulation (GO:0030194)3.14375204
99trabecula morphogenesis (GO:0061383)3.13920631
100definitive hemopoiesis (GO:0060216)3.13794344
101response to progesterone (GO:0032570)3.13532338
102renal absorption (GO:0070293)3.08613010
103polyol transport (GO:0015791)3.08094282
104hyperosmotic salinity response (GO:0042538)3.05106087
105activation of MAPKKK activity (GO:0000185)3.04612264
106embryonic process involved in female pregnancy (GO:0060136)3.04209393
107positive regulation of cartilage development (GO:0061036)3.02168880
108cell volume homeostasis (GO:0006884)3.00954244
109low-density lipoprotein particle clearance (GO:0034383)3.00734289
110embryonic heart tube development (GO:0035050)3.00715279
111radial glial cell differentiation (GO:0060019)3.00341534
112regulation of endothelial cell apoptotic process (GO:2000351)2.98472823
113basement membrane organization (GO:0071711)2.98340562
114lateral ventricle development (GO:0021670)2.98224632
115positive regulation of actin cytoskeleton reorganization (GO:2000251)2.96415270
116mRNA transcription (GO:0009299)2.95231106
117regulation of type B pancreatic cell apoptotic process (GO:2000674)2.94587528
118antigen processing and presentation of endogenous antigen (GO:0019883)2.94366141
119embryonic foregut morphogenesis (GO:0048617)2.93192381
120positive regulation of coagulation (GO:0050820)2.92710967
121positive regulation of lamellipodium assembly (GO:0010592)2.92576408
122regulation of epithelial cell migration (GO:0010632)2.92568398
123positive regulation of epithelial cell migration (GO:0010634)2.90310472
124angiogenesis (GO:0001525)2.90245401
125regulation of blood vessel endothelial cell migration (GO:0043535)2.89826083
126regulation of endothelial cell proliferation (GO:0001936)2.88344648
127regulation of transforming growth factor beta1 production (GO:0032908)2.87391174
128response to UV-B (GO:0010224)2.86510919
129regulation of transmission of nerve impulse (GO:0051969)2.86214628
130positive regulation of protein import into nucleus, translocation (GO:0033160)2.84995669
131negative regulation of gluconeogenesis (GO:0045721)2.82790410
132auditory behavior (GO:0031223)2.82636143
133regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.82604893
134regulation of Rap GTPase activity (GO:0032317)2.82275768
135negative regulation of angiogenesis (GO:0016525)2.81911508
136positive regulation of glial cell differentiation (GO:0045687)2.79706627
137positive regulation of transforming growth factor beta production (GO:0071636)2.76251351
138membrane protein intracellular domain proteolysis (GO:0031293)2.75719599
139regulation of inclusion body assembly (GO:0090083)2.74862647
140vasculature development (GO:0001944)2.69980700
141negative regulation of blood vessel morphogenesis (GO:2000181)2.69889018
142wound healing, spreading of cells (GO:0044319)2.69862100
143endoderm formation (GO:0001706)2.68863605
144negative regulation of cell fate specification (GO:0009996)2.68119793
145chemical homeostasis within a tissue (GO:0048875)2.67539329
146regulation of establishment or maintenance of cell polarity (GO:0032878)2.67016239
147negative regulation of focal adhesion assembly (GO:0051895)2.65789021
148negative regulation of cell junction assembly (GO:1901889)2.65789021
149negative regulation of adherens junction organization (GO:1903392)2.65789021
150endothelial cell proliferation (GO:0001935)2.64837371
151regulation of T-helper 2 cell differentiation (GO:0045628)2.64567190
152lung vasculature development (GO:0060426)2.63690819
153regulation of synapse structural plasticity (GO:0051823)2.63487143
154positive regulation of fibroblast migration (GO:0010763)2.60246288
155cellular response to glucose starvation (GO:0042149)2.59719997
156cellular response to interleukin-1 (GO:0071347)2.58363415
157lymph vessel development (GO:0001945)10.4915278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.90523512
2GATA2_21666600_ChIP-Seq_HMVEC_Human4.06115356
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.82425049
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.44997102
5CLOCK_20551151_ChIP-Seq_293T_Human3.22709423
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.17052666
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.10272311
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.10272311
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.10272311
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87168359
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.56989984
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.46250147
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.43790273
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.41912559
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39734336
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.37069211
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.35922310
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.25737044
19* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21947014
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18608258
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.13319024
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13018427
23KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11087813
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98789953
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.96688425
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95036806
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86953814
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86762183
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85905924
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85629806
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.67217858
32GATA1_19941826_ChIP-Seq_K562_Human1.66446390
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65300300
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65145431
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64812711
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64088283
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.63164253
38RUNX_20019798_ChIP-Seq_JUKART_Human1.62433028
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60578887
40CJUN_26792858_Chip-Seq_BT549_Human1.58367852
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.57731381
42CDX2_20551321_ChIP-Seq_CACO-2_Human1.53604071
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52542918
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52011899
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.51140982
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49997241
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49364015
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49302791
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47759150
50FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.46230445
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45519177
52AHR_22903824_ChIP-Seq_MCF-7_Human1.44891459
53SOX2_20726797_ChIP-Seq_SW620_Human1.41693290
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41262046
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41262046
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39900641
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39619301
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38587785
59CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38208948
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.37439519
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.34975510
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.33716913
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.33716913
64EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32727148
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32727148
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29862342
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26353960
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26047496
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24738891
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24665141
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24382141
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23938648
73SPI1_23127762_ChIP-Seq_K562_Human1.23606881
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21819158
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20400831
76* BP1_19119308_ChIP-ChIP_Hs578T_Human1.20115359
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19506097
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19179718
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18869917
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17921807
81DROSHA_22980978_ChIP-Seq_HELA_Human1.17833031
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17826465
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17763570
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17763570
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.14434307
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13934335
87NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13628055
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13239991
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13142680
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12713526
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.11603168
92* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10775524
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10767442
94VDR_24787735_ChIP-Seq_THP-1_Human1.10428691
95KDM2B_26808549_Chip-Seq_DND41_Human1.08889511
96TCF7_22412390_ChIP-Seq_EML_Mouse1.07277253
97AR_21572438_ChIP-Seq_LNCaP_Human1.06543447
98TP53_18474530_ChIP-ChIP_U2OS_Human1.05625944
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05399696
100BRD4_25478319_ChIP-Seq_HGPS_Human1.04779079
101LXR_22158963_ChIP-Seq_LIVER_Mouse1.04733066
102RXR_22108803_ChIP-Seq_LS180_Human1.04585042
103MAF_26560356_Chip-Seq_TH1_Human1.03580845
104RACK7_27058665_Chip-Seq_MCF-7_Human1.03036842
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.03007046
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02976542
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.02724935
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.99350192
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99088747
110KDM2B_26808549_Chip-Seq_K562_Human0.98798019
111UBF1/2_26484160_Chip-Seq_HMECs_Human0.98224628
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97613015
113PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95783534
114SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93668024
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93125447
116GATA2_19941826_ChIP-Seq_K562_Human0.93068181
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93006647
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.92834336
119LXR_22292898_ChIP-Seq_THP-1_Human0.92471036
120TCF4_18268006_ChIP-ChIP_LS174T_Human0.91512841
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90843560
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90651104
123MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90271582
124GATA1_22025678_ChIP-Seq_K562_Human0.89997780
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.88853213
126RING1B_27294783_Chip-Seq_ESCs_Mouse0.88364227
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88294610
128MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88185258
129* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87834430
130SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86985449
131ZNF263_19887448_ChIP-Seq_K562_Human0.86348998
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85708249
133NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85592443
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82209443
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81436782
136SCL_19346495_ChIP-Seq_HPC-7_Human0.81400573
137* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80610313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to7.85534935
2MP0010368_abnormal_lymphatic_system7.43747656
3MP0001879_abnormal_lymphatic_vessel5.68090980
4MP0006054_spinal_hemorrhage5.57829289
5MP0004510_myositis5.33931512
6MP0008004_abnormal_stomach_pH4.13102603
7MP0000013_abnormal_adipose_tissue3.44069640
8MP0003300_gastrointestinal_ulcer3.37514762
9MP0005167_abnormal_blood-brain_barrier3.30800008
10MP0004272_abnormal_basement_membrane3.22589067
11MP0001853_heart_inflammation2.94965011
12MP0003303_peritoneal_inflammation2.65361997
13* MP0001851_eye_inflammation2.44530753
14MP0003828_pulmonary_edema2.25218152
15MP0009278_abnormal_bone_marrow2.03583195
16MP0003195_calcinosis2.00764994
17MP0004215_abnormal_myocardial_fiber1.90575259
18MP0005084_abnormal_gallbladder_morpholo1.75497119
19MP0000465_gastrointestinal_hemorrhage1.71236197
20MP0005409_darkened_coat_color1.63926826
21MP0000767_abnormal_smooth_muscle1.60510030
22MP0000343_altered_response_to1.56400342
23MP0005275_abnormal_skin_tensile1.55112519
24MP0009840_abnormal_foam_cell1.53766507
25MP0001533_abnormal_skeleton_physiology1.53103177
26MP0001873_stomach_inflammation1.49670462
27MP0004484_altered_response_of1.47065644
28MP0010234_abnormal_vibrissa_follicle1.46058231
29MP0000249_abnormal_blood_vessel1.45936833
30MP0005166_decreased_susceptibility_to1.45488159
31MP0000733_abnormal_muscle_development1.40399042
32MP0004808_abnormal_hematopoietic_stem1.38758327
33MP0003566_abnormal_cell_adhesion1.35073568
34MP0000003_abnormal_adipose_tissue1.34096482
35MP0003279_aneurysm1.33261438
36MP0002060_abnormal_skin_morphology1.32657698
37MP0002396_abnormal_hematopoietic_system1.32247358
38MP0003091_abnormal_cell_migration1.31130877
39MP0005164_abnormal_response_to1.30463816
40MP0004147_increased_porphyrin_level1.29214785
41MP0010352_gastrointestinal_tract_polyps1.27948059
42MP0008438_abnormal_cutaneous_collagen1.27657491
43MP0002009_preneoplasia1.23832790
44MP0001915_intracranial_hemorrhage1.23816025
45MP0002925_abnormal_cardiovascular_devel1.17366686
46MP0004883_abnormal_blood_vessel1.13538940
47MP0003448_altered_tumor_morphology1.12187542
48MP0005623_abnormal_meninges_morphology1.11489097
49MP0005595_abnormal_vascular_smooth1.11233145
50MP0005397_hematopoietic_system_phenotyp1.11045809
51MP0001545_abnormal_hematopoietic_system1.11045809
52MP0004782_abnormal_surfactant_physiolog1.10428637
53MP0000516_abnormal_urinary_system1.08110767
54MP0005367_renal/urinary_system_phenotyp1.08110767
55MP0002928_abnormal_bile_duct1.07756687
56MP0002128_abnormal_blood_circulation1.05917697
57MP0004084_abnormal_cardiac_muscle1.05415392
58* MP0002405_respiratory_system_inflammati1.02564955
59MP0002933_joint_inflammation1.02349016
60* MP0001614_abnormal_blood_vessel1.00750636
61MP0001958_emphysema0.93702398
62MP0010155_abnormal_intestine_physiology0.92166300
63MP0003633_abnormal_nervous_system0.91966295
64MP0003705_abnormal_hypodermis_morpholog0.90401363
65MP0005390_skeleton_phenotype0.89231390
66MP0002254_reproductive_system_inflammat0.88576456
67MP0004130_abnormal_muscle_cell0.88300528
68MP0002168_other_aberrant_phenotype0.88279023
69MP0002098_abnormal_vibrissa_morphology0.87728142
70MP0001784_abnormal_fluid_regulation0.87211588
71MP0005670_abnormal_white_adipose0.86041437
72MP0005023_abnormal_wound_healing0.85121460
73MP0003943_abnormal_hepatobiliary_system0.83579184
74MP0002295_abnormal_pulmonary_circulatio0.82893820
75MP0003191_abnormal_cellular_cholesterol0.82646433
76MP0001216_abnormal_epidermal_layer0.82066052
77MP0000750_abnormal_muscle_regeneration0.81527094
78MP0009785_altered_susceptibility_to0.81468751
79MP0002127_abnormal_cardiovascular_syste0.81080875
80MP0003385_abnormal_body_wall0.80499644
81MP0001835_abnormal_antigen_presentation0.78843904
82MP0005503_abnormal_tendon_morphology0.78044319
83* MP0002419_abnormal_innate_immunity0.76108799
84MP0002138_abnormal_hepatobiliary_system0.75035728
85MP0002332_abnormal_exercise_endurance0.75007719
86MP0005165_increased_susceptibility_to0.74848459
87MP0002090_abnormal_vision0.74325238
88MP0001191_abnormal_skin_condition0.73715436
89MP0005508_abnormal_skeleton_morphology0.73007443
90MP0006138_congestive_heart_failure0.72010448
91MP0003638_abnormal_response/metabolism_0.70688858
92MP0005000_abnormal_immune_tolerance0.70481828
93MP0002133_abnormal_respiratory_system0.69857860
94MP0005388_respiratory_system_phenotype0.69857860
95* MP0005025_abnormal_response_to0.67326144
96MP0001542_abnormal_bone_strength0.67064830
97MP0001243_abnormal_dermal_layer0.67046482
98MP0000751_myopathy0.66547631
99MP0002972_abnormal_cardiac_muscle0.66443470
100MP0002089_abnormal_postnatal_growth/wei0.65888335
101MP0003075_altered_response_to0.65387900
102MP0003690_abnormal_glial_cell0.65240024
103MP0003045_fibrosis0.64617919
104MP0003868_abnormal_feces_composition0.64426768
105MP0003941_abnormal_skin_development0.64215402
106MP0004947_skin_inflammation0.64079461
107MP0001544_abnormal_cardiovascular_syste0.63914121
108MP0005385_cardiovascular_system_phenoty0.63914121
109MP0000467_abnormal_esophagus_morphology0.63744058
110MP0002166_altered_tumor_susceptibility0.63413591
111MP0009764_decreased_sensitivity_to0.62416654
112MP0000266_abnormal_heart_morphology0.62216457
113MP0000462_abnormal_digestive_system0.61700283
114MP0002086_abnormal_extraembryonic_tissu0.61342207
115MP0005375_adipose_tissue_phenotype0.60665551
116MP0002998_abnormal_bone_remodeling0.60534182
117MP0001800_abnormal_humoral_immune0.60415823
118MP0003453_abnormal_keratinocyte_physiol0.59711278
119MP0004085_abnormal_heartbeat0.59403735
120MP0005083_abnormal_biliary_tract0.59392909
121MP0003950_abnormal_plasma_membrane0.58925621
122MP0010771_integument_phenotype0.58816250
123MP0002896_abnormal_bone_mineralization0.58780593
124MP0009763_increased_sensitivity_to0.58756049
125MP0000377_abnormal_hair_follicle0.58612012
126MP0001501_abnormal_sleep_pattern0.58418903
127MP0003436_decreased_susceptibility_to0.57052447
128MP0003866_abnormal_defecation0.56863525
129MP0002796_impaired_skin_barrier0.55814286
130MP0010630_abnormal_cardiac_muscle0.55473972
131MP0002088_abnormal_embryonic_growth/wei0.55284603
132* MP0002148_abnormal_hypersensitivity_rea0.53398616
133MP0000383_abnormal_hair_follicle0.52590253
134MP0008874_decreased_physiological_sensi0.51245656
135MP0001663_abnormal_digestive_system0.51201719
136MP0002877_abnormal_melanocyte_morpholog0.50190791

Predicted human phenotypes

RankGene SetZ-score
1Nonimmune hydrops fetalis (HP:0001790)9.67881601
2Broad metatarsal (HP:0001783)5.45232303
3Hematochezia (HP:0002573)5.41846322
4Spontaneous hematomas (HP:0007420)5.23435721
5Polycythemia (HP:0001901)5.00654052
6Capillary hemangiomas (HP:0005306)4.96958059
7Short hallux (HP:0010109)4.59716697
8Hypotrichosis (HP:0001006)4.57519674
9Abnormality of the nasal mucosa (HP:0000433)4.50548476
10Aplasia/Hypoplasia of the hallux (HP:0008362)4.26731340
11Prostate neoplasm (HP:0100787)4.25095287
12Cerebral aneurysm (HP:0004944)4.01970284
13Esophageal varix (HP:0002040)3.89010162
14Lymphedema (HP:0001004)3.85948211
15Congenital, generalized hypertrichosis (HP:0004540)3.77571287
16Lymphangioma (HP:0100764)3.77008214
17Joint hemorrhage (HP:0005261)3.74838687
18Hypoplastic ischia (HP:0003175)3.72937008
19Delayed CNS myelination (HP:0002188)3.56210298
20Abnormality of the ischium (HP:0003174)3.52608900
21Conjunctival telangiectasia (HP:0000524)3.42695604
22Woolly hair (HP:0002224)3.20032526
23Increased connective tissue (HP:0009025)3.17331164
24Deep venous thrombosis (HP:0002625)3.12800167
25Venous insufficiency (HP:0005293)3.12159276
26Venous abnormality (HP:0002624)3.10632222
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.09401647
28Cerebral hemorrhage (HP:0001342)3.06791747
29Ulnar claw (HP:0001178)3.04743292
30Premature rupture of membranes (HP:0001788)2.99991994
31Porencephaly (HP:0002132)2.96932049
32Abnormality of the intrinsic pathway (HP:0010989)2.96235940
33Abnormality of the vasculature of the conjunctiva (HP:0008054)2.88215143
34Elevated erythrocyte sedimentation rate (HP:0003565)2.86775619
35Prominent supraorbital ridges (HP:0000336)2.86337096
36Hemorrhage of the eye (HP:0011885)2.84884895
37Ventricular tachycardia (HP:0004756)2.77029751
38Aortic aneurysm (HP:0004942)2.76735924
39Cardiovascular calcification (HP:0011915)2.75541472
40Curly hair (HP:0002212)2.74607926
41Absent toe (HP:0010760)2.68267735
42Abnormal pancreas size (HP:0012094)2.67024498
43Vascular calcification (HP:0004934)2.66676878
44Hemiplegia (HP:0002301)2.64747490
45Right ventricular cardiomyopathy (HP:0011663)2.64549148
46Segmental peripheral demyelination/remyelination (HP:0003481)2.63656407
47Protrusio acetabuli (HP:0003179)2.60333935
48Muscle fiber splitting (HP:0003555)2.59950708
49Abnormality of the peritoneum (HP:0002585)2.59876254
50Aneurysm (HP:0002617)2.58515955
51Periorbital edema (HP:0100539)2.52119090
52Pulmonary artery stenosis (HP:0004415)2.51809267
53Hydroureter (HP:0000072)2.51621792
54Reduced subcutaneous adipose tissue (HP:0003758)2.51327472
55Polygenic inheritance (HP:0010982)2.50072361
56Facial edema (HP:0000282)2.49935547
57Portal hypertension (HP:0001409)2.49872774
58Aortic dissection (HP:0002647)2.47467969
59Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47034883
60Short 4th metacarpal (HP:0010044)2.47034883
61Palpebral edema (HP:0100540)2.45904666
62Cardiomegaly (HP:0001640)2.45660151
63Adactyly (HP:0009776)2.43605703
64Preaxial foot polydactyly (HP:0001841)2.42819368
65Absent eyelashes (HP:0000561)2.42516511
66Large for gestational age (HP:0001520)2.41172363
67Diplopia (HP:0000651)2.39317172
68Abnormality of binocular vision (HP:0011514)2.39317172
69Tetraparesis (HP:0002273)2.38174775
70Colitis (HP:0002583)2.36820770
71Distal lower limb muscle weakness (HP:0009053)2.36600965
72Vascular tortuosity (HP:0004948)2.34682341
73Stomach cancer (HP:0012126)2.33278941
74Short chin (HP:0000331)2.31657404
75Hypoplasia of the uterus (HP:0000013)2.27136052
76Bicuspid aortic valve (HP:0001647)2.26313337
77Absent eyebrow (HP:0002223)2.24711780
78Visceral angiomatosis (HP:0100761)2.24126908
79Accelerated skeletal maturation (HP:0005616)2.23177891
80Abnormality of the hepatic vasculature (HP:0006707)2.22792997
81Abnormality of complement system (HP:0005339)2.22667069
82Cellulitis (HP:0100658)2.20494162
83Myositis (HP:0100614)2.18711304
84Myocardial infarction (HP:0001658)2.17027029
85Hemangiomatosis (HP:0007461)2.16688283
86Large hands (HP:0001176)2.16678254
87Absent hand (HP:0004050)2.16058092
88Chondrocalcinosis (HP:0000934)2.15862754
89Hypoplasia of the iris (HP:0007676)2.15563238
90Ovoid vertebral bodies (HP:0003300)2.15263453
91Facial diplegia (HP:0001349)2.14286405
92Low anterior hairline (HP:0000294)2.14058090
93Persistence of primary teeth (HP:0006335)2.11780756
94Hemiparesis (HP:0001269)2.11122631
95Osteomalacia (HP:0002749)2.11036253
96Spinal rigidity (HP:0003306)2.10839368
97Pulmonary embolism (HP:0002204)2.09462685
98Aortic valve stenosis (HP:0001650)2.09347899
99Abnormality of the sella turcica (HP:0002679)2.08714362
100Mucosal telangiectasiae (HP:0100579)2.07952087
101Popliteal pterygium (HP:0009756)2.07800494
102Complement deficiency (HP:0004431)2.06800523
103Insidious onset (HP:0003587)2.06355987
104Termporal pattern (HP:0011008)2.06355987
105Arterial tortuosity (HP:0005116)2.06073287
106Paralysis (HP:0003470)2.05608998
107Prolonged bleeding time (HP:0003010)2.05445999
108Absent hair (HP:0002298)2.05209793
109Abnormality of Sharpey fibers (HP:0100685)2.02755883
110Toxemia of pregnancy (HP:0100603)2.02705235
111Atonic seizures (HP:0010819)2.00654144
112Epidermoid cyst (HP:0200040)2.00315099
1132-3 toe syndactyly (HP:0004691)2.00283316
114Dry hair (HP:0011359)2.00066652
115Shallow orbits (HP:0000586)1.98531796
116Hypoalphalipoproteinemia (HP:0003233)1.98476345
117Skull defect (HP:0001362)1.98405988
118Abnormality of the pericardium (HP:0001697)1.98088064
119Interstitial pulmonary disease (HP:0006530)1.96839095
120Stroke (HP:0001297)1.95846551
121Protruding ear (HP:0000411)1.93442535
122Pulmonic stenosis (HP:0001642)1.92827274
123Cutis marmorata (HP:0000965)1.92223031
124Areflexia of lower limbs (HP:0002522)1.91719654
125Mitral valve prolapse (HP:0001634)1.90029950
126Supraventricular arrhythmia (HP:0005115)1.88746971
127Menorrhagia (HP:0000132)1.88405388
128Bladder diverticulum (HP:0000015)1.88140653
129Hyporeflexia of lower limbs (HP:0002600)1.86808746
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86021050
131Systemic lupus erythematosus (HP:0002725)1.85075191
132Orchitis (HP:0100796)1.85048264
133Chronic otitis media (HP:0000389)1.84907277
134Multifactorial inheritance (HP:0001426)1.84449707
135Subacute progressive viral hepatitis (HP:0006572)1.83278988
136Facial shape deformation (HP:0011334)1.82638546
137Potter facies (HP:0002009)1.82638546
138Long eyelashes (HP:0000527)1.82366465
139Thrombophlebitis (HP:0004418)1.81299898
140Rectal prolapse (HP:0002035)1.80885254
141Cubitus valgus (HP:0002967)1.80432765
142Thoracolumbar scoliosis (HP:0002944)1.79516097
143Thick nail (HP:0001805)1.77874678
144Bilateral sensorineural hearing impairment (HP:0008619)1.77587712
145Osteolytic defects of the hand bones (HP:0009699)1.77573867
146Osteolytic defects of the phalanges of the hand (HP:0009771)1.77573867
147Abnormality of the periventricular white matter (HP:0002518)1.77451912
148Atrial fibrillation (HP:0005110)1.76670718
149Difficulty climbing stairs (HP:0003551)1.76454812
150Abnormality of the prostate (HP:0008775)1.76278020
151Broad hallux (HP:0010055)1.76115485
152Abnormality of the anterior chamber (HP:0000593)1.72271224
153Poor eye contact (HP:0000817)1.67460737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.82565027
2TGFBR23.95903062
3TGFBR13.52241817
4RIPK12.61220952
5ERN12.04162818
6KDR10.8538962
7EPHB11.92268326
8NLK1.82412148
9JAK11.66786610
10JAK31.53374724
11MAP3K31.47904177
12PTK2B1.47854093
13MAP3K141.43649260
14RPS6KA51.36824716
15EPHB21.19141986
16CAMK41.18066756
17IRAK11.15962906
18PTK61.08965427
19TAF11.07794965
20MAP2K31.06808184
21RPS6KA61.05112722
22JAK21.02574691
23TNIK1.02273584
24FER0.98141984
25DDR20.97840854
26GRK10.97043013
27TBK10.96011925
28EEF2K0.92896933
29EIF2AK30.90903336
30CSK0.88633618
31STK390.87541587
32FES0.79553486
33MAPK120.78599563
34PTK20.74843214
35MAPK150.73194054
36LATS10.71990810
37PDK20.67511791
38FGFR40.67422659
39PNCK0.67157648
40LATS20.66677517
41PRKCH0.65475451
42MAPKAPK50.64297995
43PRKG20.63999105
44TYK20.62946797
45MAPK70.61546274
46PAK40.58146531
47EPHA30.57833393
48FGFR30.56792975
49IKBKE0.55836782
50MAP3K20.53367739
51OXSR10.53086728
52CDK90.53025997
53CLK10.51953172
54PIK3CA0.51791985
55TTN0.50935102
56STK100.50047366
57MOS0.48850565
58MAP4K10.48370845
59WEE10.47620272
60PRKAA20.47198757
61GSK3A0.46689321
62RET0.46177923
63MAP3K110.45618951
64DMPK0.45495204
65TEC0.43809691
66PDGFRA0.43631776
67TRPM70.42308467
68IGF1R0.41475844
69BMPR20.41404894
70MAP3K60.41268501
71EGFR0.40587136
72BMPR1B0.40259433
73VRK10.40175054
74CDC42BPA0.39434199
75MAP3K10.39229890
76MYLK0.38912647
77CDK60.38614032
78DAPK20.37427516
79EPHA20.37361762
80MET0.37113464
81IKBKB0.37037425
82INSRR0.36688124
83GRK50.36687348
84SIK30.36576291
85TSSK60.35817165
86MAPK40.35629966
87CHUK0.35157628
88PAK20.34410354
89MARK30.34071335
90PRKD10.33552741
91IRAK20.32710849
92SRC0.32351731
93PKN20.32262368
94ITK0.31652754
95MKNK20.30232173
96SGK20.30194934
97KIT0.30046059
98INSR0.28954869
99CDK120.27997390
100MAP2K10.26161294
101CDK30.25559146
102HCK0.25123705
103RPS6KA40.24822879
104LCK0.24653044
105PDGFRB0.24605494
106STK30.24007184
107LRRK20.23800248
108PIM20.23486593
109PRKD20.23383257
110BRSK20.23328088
111LYN0.21857915
112FLT30.21512582
113MAPK30.20405035
114NEK60.19726009
115IRAK30.19250564
116MAP3K100.18248138
117MAPKAPK20.17238056
118HIPK20.16907676
119YES10.16875739
120STK38L0.16482616
121NTRK10.15274378
122ABL10.15201867
123SIK20.15113889
124SIK10.14820498
125MTOR0.14745647
126MARK20.14575924
127SGK30.14245262
128CDK80.14101949
129IRAK40.14098243
130BMX0.13917146
131ERBB30.13289278
132MATK0.12962906
133EIF2AK20.12533453
134STK110.12084908
135ZAP700.12043253
136BLK0.11753220
137PIM10.11367753
138PRKCD0.11090571
139SCYL20.10436094
140MAP2K20.10370669
141FGFR20.10031135
142AKT30.09645516
143MAPK10.09431924

Predicted pathways (KEGG)

RankGene SetZ-score
1* Malaria_Homo sapiens_hsa051444.50024627
2Prion diseases_Homo sapiens_hsa050203.23664129
3Staphylococcus aureus infection_Homo sapiens_hsa051502.41926406
4Leukocyte transendothelial migration_Homo sapiens_hsa046702.32024194
5* African trypanosomiasis_Homo sapiens_hsa051432.27250242
6Complement and coagulation cascades_Homo sapiens_hsa046102.11369854
7* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.09670369
8ECM-receptor interaction_Homo sapiens_hsa045122.04849799
9Focal adhesion_Homo sapiens_hsa045102.02949260
10* TNF signaling pathway_Homo sapiens_hsa046681.93282501
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.88486524
12Osteoclast differentiation_Homo sapiens_hsa043801.82087807
13* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.81171579
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.74326870
15Dorso-ventral axis formation_Homo sapiens_hsa043201.63313260
16Rap1 signaling pathway_Homo sapiens_hsa040151.58141058
17Leishmaniasis_Homo sapiens_hsa051401.57787914
18Prostate cancer_Homo sapiens_hsa052151.53880466
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52984150
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.49032156
21Toxoplasmosis_Homo sapiens_hsa051451.48518224
22Acute myeloid leukemia_Homo sapiens_hsa052211.48064842
23Notch signaling pathway_Homo sapiens_hsa043301.47215308
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.46294350
25Adherens junction_Homo sapiens_hsa045201.45845282
26Bile secretion_Homo sapiens_hsa049761.38799151
27Cocaine addiction_Homo sapiens_hsa050301.35754314
28Platelet activation_Homo sapiens_hsa046111.32657266
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32470077
30PI3K-Akt signaling pathway_Homo sapiens_hsa041511.30469140
31Small cell lung cancer_Homo sapiens_hsa052221.28473966
32Pertussis_Homo sapiens_hsa051331.23957229
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23138431
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19942920
35Viral myocarditis_Homo sapiens_hsa054161.19506109
36Hematopoietic cell lineage_Homo sapiens_hsa046401.18305397
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17120210
38Shigellosis_Homo sapiens_hsa051311.17058609
39Amoebiasis_Homo sapiens_hsa051461.15126837
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12577357
41Hepatitis C_Homo sapiens_hsa051601.12005688
42Renin secretion_Homo sapiens_hsa049241.11257947
43Proteoglycans in cancer_Homo sapiens_hsa052051.10497299
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08796766
45Dilated cardiomyopathy_Homo sapiens_hsa054141.07801789
46Influenza A_Homo sapiens_hsa051641.06578697
47Measles_Homo sapiens_hsa051621.06364968
48Antigen processing and presentation_Homo sapiens_hsa046121.05094457
49ABC transporters_Homo sapiens_hsa020101.04701606
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02597064
51Axon guidance_Homo sapiens_hsa043601.01637151
52Legionellosis_Homo sapiens_hsa051340.99509952
53Ovarian steroidogenesis_Homo sapiens_hsa049130.99247018
54Vitamin digestion and absorption_Homo sapiens_hsa049770.99097234
55HTLV-I infection_Homo sapiens_hsa051660.99089011
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98151386
57Apoptosis_Homo sapiens_hsa042100.97984436
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.97443981
59FoxO signaling pathway_Homo sapiens_hsa040680.96512985
60Ras signaling pathway_Homo sapiens_hsa040140.96503585
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96127931
62Insulin resistance_Homo sapiens_hsa049310.95227895
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94885126
64VEGF signaling pathway_Homo sapiens_hsa043700.94476270
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92161048
66Salmonella infection_Homo sapiens_hsa051320.91370150
67Rheumatoid arthritis_Homo sapiens_hsa053230.89175684
68Pathways in cancer_Homo sapiens_hsa052000.84438853
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82103750
70Estrogen signaling pathway_Homo sapiens_hsa049150.79676138
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79310830
72B cell receptor signaling pathway_Homo sapiens_hsa046620.78311048
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.77241219
74Chemokine signaling pathway_Homo sapiens_hsa040620.76916511
75Protein digestion and absorption_Homo sapiens_hsa049740.75974831
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74264609
77Bladder cancer_Homo sapiens_hsa052190.73379592
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72910129
79Chronic myeloid leukemia_Homo sapiens_hsa052200.72734121
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72427406
81T cell receptor signaling pathway_Homo sapiens_hsa046600.71435314
82HIF-1 signaling pathway_Homo sapiens_hsa040660.69654317
83Thyroid cancer_Homo sapiens_hsa052160.69319031
84Hepatitis B_Homo sapiens_hsa051610.68857395
85cAMP signaling pathway_Homo sapiens_hsa040240.68807011
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66907642
87Circadian rhythm_Homo sapiens_hsa047100.66826042
88Mineral absorption_Homo sapiens_hsa049780.65388600
89MicroRNAs in cancer_Homo sapiens_hsa052060.64980056
90Pancreatic cancer_Homo sapiens_hsa052120.64860053
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63940592
92Renal cell carcinoma_Homo sapiens_hsa052110.63128843
93Gap junction_Homo sapiens_hsa045400.62437674
94TGF-beta signaling pathway_Homo sapiens_hsa043500.62434728
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59176697
96Herpes simplex infection_Homo sapiens_hsa051680.58595348
97Prolactin signaling pathway_Homo sapiens_hsa049170.58236529
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.58190613
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55158830
100Viral carcinogenesis_Homo sapiens_hsa052030.55022858
101Hippo signaling pathway_Homo sapiens_hsa043900.54706308
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53064547
103Phagosome_Homo sapiens_hsa041450.52895558
104MAPK signaling pathway_Homo sapiens_hsa040100.52779544
105Endocytosis_Homo sapiens_hsa041440.51919790
106Tuberculosis_Homo sapiens_hsa051520.51341990
107Tight junction_Homo sapiens_hsa045300.50251337
108GnRH signaling pathway_Homo sapiens_hsa049120.49723598
109Nitrogen metabolism_Homo sapiens_hsa009100.48886249
110Colorectal cancer_Homo sapiens_hsa052100.48578838
111Endometrial cancer_Homo sapiens_hsa052130.48497002
112Choline metabolism in cancer_Homo sapiens_hsa052310.47254442
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.46978299
114Oxytocin signaling pathway_Homo sapiens_hsa049210.46738623
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45971939
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45438625
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45184297
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.44835233
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44591845
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44325062
121Phototransduction_Homo sapiens_hsa047440.41867916
122ErbB signaling pathway_Homo sapiens_hsa040120.40635126

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