SELENBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.95531476
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.95531476
3L-phenylalanine metabolic process (GO:0006558)5.80569257
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.80569257
5sulfur amino acid catabolic process (GO:0000098)5.80011612
6ethanol oxidation (GO:0006069)5.57387518
7cysteine metabolic process (GO:0006534)5.37349093
8aromatic amino acid family catabolic process (GO:0009074)5.32698729
9glyoxylate metabolic process (GO:0046487)5.20514771
10flavonoid metabolic process (GO:0009812)4.94090096
11indole-containing compound catabolic process (GO:0042436)4.79531536
12indolalkylamine catabolic process (GO:0046218)4.79531536
13tryptophan catabolic process (GO:0006569)4.79531536
14alpha-linolenic acid metabolic process (GO:0036109)4.71693469
15lysine metabolic process (GO:0006553)4.64048076
16lysine catabolic process (GO:0006554)4.64048076
17kynurenine metabolic process (GO:0070189)4.62263938
18homocysteine metabolic process (GO:0050667)4.61800721
19bile acid biosynthetic process (GO:0006699)4.59517563
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.55494058
21drug catabolic process (GO:0042737)4.55199996
22urea cycle (GO:0000050)4.55092991
23urea metabolic process (GO:0019627)4.55092991
24tryptophan metabolic process (GO:0006568)4.50815959
25ethanol metabolic process (GO:0006067)4.48673437
26xenobiotic catabolic process (GO:0042178)4.46926075
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.46212644
28cellular ketone body metabolic process (GO:0046950)4.43100478
29negative regulation of fibrinolysis (GO:0051918)4.38853331
30amino-acid betaine metabolic process (GO:0006577)4.38135293
31exogenous drug catabolic process (GO:0042738)4.34911121
32complement activation, alternative pathway (GO:0006957)4.26576240
33nitrogen cycle metabolic process (GO:0071941)4.19835208
34cellular glucuronidation (GO:0052695)4.15817306
35short-chain fatty acid metabolic process (GO:0046459)4.08103115
36regulation of protein activation cascade (GO:2000257)4.06703291
37bile acid metabolic process (GO:0008206)4.05517705
38serine family amino acid catabolic process (GO:0009071)4.04708016
39drug transmembrane transport (GO:0006855)4.04193938
40regulation of fibrinolysis (GO:0051917)4.02625365
41high-density lipoprotein particle remodeling (GO:0034375)4.01952355
42epoxygenase P450 pathway (GO:0019373)4.01774400
43surfactant homeostasis (GO:0043129)4.00615230
44peptidyl-glutamic acid carboxylation (GO:0017187)3.96594445
45protein carboxylation (GO:0018214)3.96594445
46drug metabolic process (GO:0017144)3.94820285
47bile acid and bile salt transport (GO:0015721)3.93731712
48NADH metabolic process (GO:0006734)3.93102644
49response to nitrosative stress (GO:0051409)3.87292741
50regulation of complement activation (GO:0030449)3.86736794
51fatty acid oxidation (GO:0019395)3.85674095
52ketone body metabolic process (GO:1902224)3.85635105
53regulation of triglyceride catabolic process (GO:0010896)3.85588625
54aromatic amino acid family metabolic process (GO:0009072)3.83746007
55glucuronate metabolic process (GO:0019585)3.82686515
56uronic acid metabolic process (GO:0006063)3.82686515
57primary alcohol catabolic process (GO:0034310)3.82361820
58benzene-containing compound metabolic process (GO:0042537)3.80225119
59lipid oxidation (GO:0034440)3.78082388
60fatty acid beta-oxidation (GO:0006635)3.77595071
61alpha-amino acid catabolic process (GO:1901606)3.77048893
62negative regulation of sterol transport (GO:0032372)3.75162950
63negative regulation of cholesterol transport (GO:0032375)3.75162950
64carnitine metabolic process (GO:0009437)3.73869880
65iron ion import (GO:0097286)3.71047875
66urate metabolic process (GO:0046415)3.69704081
67response to mercury ion (GO:0046689)3.68561375
68cellular amino acid catabolic process (GO:0009063)3.66789561
69tyrosine metabolic process (GO:0006570)3.63382039
70aldehyde catabolic process (GO:0046185)3.61134732
71desmosome organization (GO:0002934)3.59136917
72regulation of cholesterol homeostasis (GO:2000188)3.59121875
73regulation of plasminogen activation (GO:0010755)3.58852010
74glutathione derivative biosynthetic process (GO:1901687)3.58520489
75glutathione derivative metabolic process (GO:1901685)3.58520489
76omega-hydroxylase P450 pathway (GO:0097267)3.57175344
77reverse cholesterol transport (GO:0043691)3.53512268
78calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.51848987
79protoporphyrinogen IX metabolic process (GO:0046501)3.48818930
80primary alcohol metabolic process (GO:0034308)3.47701225
81fatty acid catabolic process (GO:0009062)3.47412385
82monocarboxylic acid catabolic process (GO:0072329)3.47348266
83glutamate metabolic process (GO:0006536)3.46916210
84serine family amino acid metabolic process (GO:0009069)3.45892583
85phenylpropanoid metabolic process (GO:0009698)3.43087603
86triglyceride homeostasis (GO:0070328)3.43055178
87acylglycerol homeostasis (GO:0055090)3.43055178
88cellular modified amino acid catabolic process (GO:0042219)3.42795701
89plasma lipoprotein particle remodeling (GO:0034369)3.42217096
90protein-lipid complex remodeling (GO:0034368)3.42217096
91macromolecular complex remodeling (GO:0034367)3.42217096
92organic acid catabolic process (GO:0016054)3.41937550
93carboxylic acid catabolic process (GO:0046395)3.41937550
94drug transport (GO:0015893)3.41014085
95regulation of cholesterol metabolic process (GO:0090181)3.40279509
96regulation of cholesterol esterification (GO:0010872)3.39314859
97acetyl-CoA metabolic process (GO:0006084)3.36026031
98coenzyme catabolic process (GO:0009109)3.35641677
99phospholipid efflux (GO:0033700)3.34809726
100negative regulation of lipase activity (GO:0060192)3.32929674
101valine metabolic process (GO:0006573)3.32914859
102L-ascorbic acid metabolic process (GO:0019852)3.32004806
103plasma lipoprotein particle clearance (GO:0034381)3.31529166
104regulation of cholesterol biosynthetic process (GO:0045540)3.31272210
105phospholipid homeostasis (GO:0055091)3.30265790
1062-oxoglutarate metabolic process (GO:0006103)3.30227428
107glutathione biosynthetic process (GO:0006750)3.29575565
108regulation of bile acid biosynthetic process (GO:0070857)3.29324163
109indolalkylamine metabolic process (GO:0006586)3.29270126
110intestinal absorption (GO:0050892)3.27352123
111arginine metabolic process (GO:0006525)3.24172965
112axonemal dynein complex assembly (GO:0070286)3.20917695
113positive regulation of lipoprotein lipase activity (GO:0051006)3.15422721
114positive regulation of triglyceride lipase activity (GO:0061365)3.15422721
115positive regulation of fatty acid beta-oxidation (GO:0032000)3.12567868
116sulfate transmembrane transport (GO:1902358)3.11367644
117nonribosomal peptide biosynthetic process (GO:0019184)3.09850223
118positive regulation of lipid catabolic process (GO:0050996)3.06642260
119oxaloacetate metabolic process (GO:0006107)2.95235237
120response to food (GO:0032094)2.94654046
121transcytosis (GO:0045056)2.94306083
122vitamin transmembrane transport (GO:0035461)2.91609288
123renal system process involved in regulation of blood volume (GO:0001977)2.91461341
124multicellular organismal water homeostasis (GO:0050891)2.90316910
125complement activation, classical pathway (GO:0006958)2.88862496
126regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.85971706
127alkaloid metabolic process (GO:0009820)2.84971231
128hemoglobin metabolic process (GO:0020027)2.84003802
129positive regulation of fatty acid oxidation (GO:0046321)2.82531418
130O-glycan processing (GO:0016266)2.81820287
131biotin metabolic process (GO:0006768)2.78832460
132protoporphyrinogen IX biosynthetic process (GO:0006782)2.75759343
133complement activation (GO:0006956)2.74825993
134quaternary ammonium group transport (GO:0015697)2.69055764
135regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.68902292
136bicarbonate transport (GO:0015701)2.68184562
137gas transport (GO:0015669)2.65528808
138antibacterial humoral response (GO:0019731)2.65283128
139one-carbon metabolic process (GO:0006730)2.63505510
140oligosaccharide biosynthetic process (GO:0009312)2.62567521
141proline metabolic process (GO:0006560)2.61865550
142angiotensin maturation (GO:0002003)2.61259062
143maintenance of gastrointestinal epithelium (GO:0030277)2.60348463
144carnitine transmembrane transport (GO:1902603)2.59499979
145regulation of fatty acid beta-oxidation (GO:0031998)2.59246322
146sperm capacitation (GO:0048240)2.59172626
147GDP-mannose metabolic process (GO:0019673)2.58470120
148glutamine family amino acid biosynthetic process (GO:0009084)2.57537525
149creatine metabolic process (GO:0006600)2.57310223
150phenol-containing compound catabolic process (GO:0019336)2.57053965
151oxygen transport (GO:0015671)2.56789528
152very-low-density lipoprotein particle assembly (GO:0034379)2.55447686
153protein activation cascade (GO:0072376)2.55383055
154amino-acid betaine transport (GO:0015838)2.54002872
155carnitine transport (GO:0015879)2.54002872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.09593320
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.53880609
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.00303183
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.74509144
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.16628476
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.94254641
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.96898866
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.85738506
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.16375828
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.14145233
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.97765537
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66668620
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57435324
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.57206043
15CLOCK_20551151_ChIP-Seq_293T_Human2.32421574
16GATA1_22025678_ChIP-Seq_K562_Human2.29773726
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26857155
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.19328283
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.18096311
20SOX2_27498859_Chip-Seq_STOMACH_Mouse2.09707536
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09494156
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.93740756
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74586211
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.70613452
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.66070680
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.64657362
27GATA4_25053715_ChIP-Seq_YYC3_Human1.64437591
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.58188287
29* CREB1_26743006_Chip-Seq_LNCaP_Human1.51529246
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46556071
31ZNF263_19887448_ChIP-Seq_K562_Human1.45131527
32CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44480135
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.40825697
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38678111
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37501546
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36563826
37SOX2_20726797_ChIP-Seq_SW620_Human1.36488654
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33000678
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.30167816
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.28352942
41P68_20966046_ChIP-Seq_HELA_Human1.27888468
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26565772
43SMC4_20622854_ChIP-Seq_HELA_Human1.25230654
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24043419
45GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23569050
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22408464
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21224921
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19606948
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18494755
50GATA6_25053715_ChIP-Seq_YYC3_Human1.17450882
51* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15469569
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13628115
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.11976219
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.11722378
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10886092
56* RACK7_27058665_Chip-Seq_MCF-7_Human1.10191343
57STAT1_20625510_ChIP-Seq_HELA_Human1.09805337
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09770977
59* CHD1_26751641_Chip-Seq_LNCaP_Human1.08511192
60VDR_21846776_ChIP-Seq_THP-1_Human1.07565511
61* TCF7_22412390_ChIP-Seq_EML_Mouse1.07452651
62DROSHA_22980978_ChIP-Seq_HELA_Human1.07310790
63KLF5_25053715_ChIP-Seq_YYC3_Human1.07218372
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05485504
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04031237
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02998747
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02811664
68* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02691828
69* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02442463
70KDM2B_26808549_Chip-Seq_K562_Human1.01328408
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.01022905
72CTCF_27219007_Chip-Seq_Bcells_Human0.99544356
73SA1_27219007_Chip-Seq_ERYTHROID_Human0.99263907
74BCL6_27268052_Chip-Seq_Bcells_Human0.99146049
75TP63_22573176_ChIP-Seq_HFKS_Human0.99117694
76KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98357944
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98137689
78BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97522604
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97250416
80CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97191988
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96960530
82LXR_22292898_ChIP-Seq_THP-1_Human0.94526478
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94186725
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92876207
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92352338
86NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92352338
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91890812
88DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91877613
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91279499
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91123352
91JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.90481820
92GATA1_19941826_ChIP-Seq_K562_Human0.90033126
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88821419
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.88599092
95* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88166488
96* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84554459
97GATA2_19941826_ChIP-Seq_K562_Human0.84416725
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82766374
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82656280
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81657293
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81577767
102* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80511877
103P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79082807
104RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78883832
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78758654
106GATA3_24758297_ChIP-Seq_MCF-7_Human0.78740917
107* CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.77765895
108CDX2_19796622_ChIP-Seq_MESCs_Mouse0.73277167
109* FOXA1_25552417_ChIP-Seq_VCAP_Human0.71580806
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70407396
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.69670333
112* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.69079597
113* TBX20_22328084_ChIP-Seq_HEART_Mouse0.68941615
114* TBX20_22080862_ChIP-Seq_HEART_Mouse0.68941615
115EGR1_19032775_ChIP-ChIP_M12_Human0.68566232
116HIF1A_21447827_ChIP-Seq_MCF-7_Human0.67944398
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.67255909
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.67255909
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.66027115
120RUNX1_27514584_Chip-Seq_MCF-7_Human0.65176996
121ATF3_27146783_Chip-Seq_COLON_Human0.64980903
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64901082
123CEBPB_22108803_ChIP-Seq_LS180_Human0.62469708
124HTT_18923047_ChIP-ChIP_STHdh_Human0.61384579
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.60730066
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.60118043
127SOX9_24532713_ChIP-Seq_HFSC_Mouse0.59995614
128CSB_26484114_Chip-Seq_FIBROBLAST_Human0.57779761
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.56326345
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.56309135
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.53716351
132AR_21909140_ChIP-Seq_LNCAP_Human0.53009853
133BCOR_27268052_Chip-Seq_Bcells_Human0.52905976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.95484999
2MP0005360_urolithiasis6.22799369
3MP0008875_abnormal_xenobiotic_pharmacok5.57195010
4MP0005085_abnormal_gallbladder_physiolo5.23950299
5MP0005365_abnormal_bile_salt5.10824385
6MP0003806_abnormal_nucleotide_metabolis3.95361618
7MP0005083_abnormal_biliary_tract3.19442786
8MP0003252_abnormal_bile_duct3.03236653
9MP0002138_abnormal_hepatobiliary_system3.02620656
10MP0010329_abnormal_lipoprotein_level2.96269706
11MP0003191_abnormal_cellular_cholesterol2.79001469
12MP0004858_abnormal_nervous_system2.68432324
13MP0005332_abnormal_amino_acid2.55629525
14MP0001666_abnormal_nutrient_absorption2.50630715
15MP0004019_abnormal_vitamin_homeostasis2.40947778
16MP0009840_abnormal_foam_cell2.40248822
17MP0003183_abnormal_peptide_metabolism2.17419749
18MP0004782_abnormal_surfactant_physiolog2.09834156
19MP0002118_abnormal_lipid_homeostasis1.86142009
20MP0009643_abnormal_urine_homeostasis1.84189752
21MP0003186_abnormal_redox_activity1.82567087
22MP0000609_abnormal_liver_physiology1.80240007
23MP0000566_synostosis1.79382201
24MP0003195_calcinosis1.79277646
25MP0005319_abnormal_enzyme/_coenzyme1.75172173
26MP0002876_abnormal_thyroid_physiology1.70486818
27MP0010234_abnormal_vibrissa_follicle1.65947595
28MP0005584_abnormal_enzyme/coenzyme_acti1.52826861
29MP0010368_abnormal_lymphatic_system1.45530867
30MP0009780_abnormal_chondrocyte_physiolo1.43930406
31MP0005167_abnormal_blood-brain_barrier1.43176972
32MP0005636_abnormal_mineral_homeostasis1.42773801
33MP0003705_abnormal_hypodermis_morpholog1.36079652
34MP0003868_abnormal_feces_composition1.33128579
35MP0001764_abnormal_homeostasis1.28751588
36MP0004264_abnormal_extraembryonic_tissu1.28363631
37MP0002009_preneoplasia1.22194127
38MP0009764_decreased_sensitivity_to1.20768679
39MP0003866_abnormal_defecation1.20589634
40MP0004043_abnormal_pH_regulation1.19929517
41MP0001664_abnormal_digestion1.18993523
42MP0002249_abnormal_larynx_morphology1.13228759
43MP0003656_abnormal_erythrocyte_physiolo1.12672932
44MP0002132_abnormal_respiratory_system1.12553166
45MP0002166_altered_tumor_susceptibility1.12315959
46MP0003879_abnormal_hair_cell1.10395206
47MP0005375_adipose_tissue_phenotype1.07895590
48MP0001849_ear_inflammation1.07891879
49MP0001756_abnormal_urination1.05974553
50MP0001873_stomach_inflammation1.03647588
51MP0001958_emphysema1.03508364
52MP0001881_abnormal_mammary_gland1.00357431
53MP0003724_increased_susceptibility_to0.99387556
54MP0005408_hypopigmentation0.99271242
55MP0002136_abnormal_kidney_physiology0.99185353
56MP0000598_abnormal_liver_morphology0.98037258
57MP0000678_abnormal_parathyroid_gland0.97815588
58MP0000477_abnormal_intestine_morphology0.96871819
59MP0008995_early_reproductive_senescence0.96254011
60MP0004130_abnormal_muscle_cell0.96160951
61MP0001765_abnormal_ion_homeostasis0.94412446
62MP0002168_other_aberrant_phenotype0.92511599
63MP0004947_skin_inflammation0.91695042
64MP0002796_impaired_skin_barrier0.89455644
65MP0005451_abnormal_body_composition0.88579529
66MP0005058_abnormal_lysosome_morphology0.87534544
67MP0003123_paternal_imprinting0.86492080
68MP0002254_reproductive_system_inflammat0.86050747
69MP0008469_abnormal_protein_level0.85862600
70MP0009115_abnormal_fat_cell0.85121131
71MP0010352_gastrointestinal_tract_polyps0.83350574
72MP0000003_abnormal_adipose_tissue0.80440668
73MP0006036_abnormal_mitochondrial_physio0.80040926
74MP0005670_abnormal_white_adipose0.79811699
75MP0003011_delayed_dark_adaptation0.79176660
76MP0009763_increased_sensitivity_to0.79170355
77MP0005376_homeostasis/metabolism_phenot0.79140968
78MP0009642_abnormal_blood_homeostasis0.78755371
79MP0001661_extended_life_span0.78667880
80MP0005248_abnormal_Harderian_gland0.77785182
81MP0005647_abnormal_sex_gland0.76880389
82MP0005084_abnormal_gallbladder_morpholo0.73836146
83MP0003075_altered_response_to0.72853779
84MP0003566_abnormal_cell_adhesion0.72590449
85MP0003300_gastrointestinal_ulcer0.72063726
86MP0000627_abnormal_mammary_gland0.71592902
87MP0008004_abnormal_stomach_pH0.70589868
88MP0005646_abnormal_pituitary_gland0.69434814
89MP0005666_abnormal_adipose_tissue0.69085085
90MP0010155_abnormal_intestine_physiology0.68514831
91MP0000490_abnormal_crypts_of0.66609613
92MP0002822_catalepsy0.66554875
93MP0005166_decreased_susceptibility_to0.66454073
94MP0000681_abnormal_thyroid_gland0.66314530
95MP0008260_abnormal_autophagy0.66289277
96MP0009384_cardiac_valve_regurgitation0.65343324
97MP0003045_fibrosis0.65121141
98MP0005266_abnormal_metabolism0.64981024
99MP0004147_increased_porphyrin_level0.63590012
100MP0008872_abnormal_physiological_respon0.63467955
101MP0005409_darkened_coat_color0.63048388
102MP0000604_amyloidosis0.62317067
103MP0003959_abnormal_lean_body0.62236973
104MP0005220_abnormal_exocrine_pancreas0.61838391
105MP0003690_abnormal_glial_cell0.61645076
106MP0000013_abnormal_adipose_tissue0.61537696
107MP0009765_abnormal_xenobiotic_induced0.61482411
108MP0005076_abnormal_cell_differentiation0.59442936
109MP0001879_abnormal_lymphatic_vessel0.57512408
110MP0005448_abnormal_energy_balance0.57085508
111MP0005464_abnormal_platelet_physiology0.57047507
112MP0000537_abnormal_urethra_morphology0.55863781
113MP0002078_abnormal_glucose_homeostasis0.55113845
114MP0000249_abnormal_blood_vessel0.54925130
115MP0001663_abnormal_digestive_system0.54504695
116MP0005164_abnormal_response_to0.54189128
117MP0003638_abnormal_response/metabolism_0.53751551
118MP0005334_abnormal_fat_pad0.52756759
119MP0005377_hearing/vestibular/ear_phenot0.52716482
120MP0003878_abnormal_ear_physiology0.52716482
121MP0002971_abnormal_brown_adipose0.51600717
122MP0002098_abnormal_vibrissa_morphology0.51328461
123MP0006054_spinal_hemorrhage0.51063804
124MP0009053_abnormal_anal_canal0.50859551
125MP0002060_abnormal_skin_morphology0.50737746
126MP0002295_abnormal_pulmonary_circulatio0.50603533
127MP0003453_abnormal_keratinocyte_physiol0.49842332
128MP0005381_digestive/alimentary_phenotyp0.48255817
129MP0000230_abnormal_systemic_arterial0.47781957
130MP0008873_increased_physiological_sensi0.47366565
131MP0002135_abnormal_kidney_morphology0.46682862
132MP0009697_abnormal_copulation0.45742753
133MP0000467_abnormal_esophagus_morphology0.45068703
134MP0002909_abnormal_adrenal_gland0.44263116
135MP0000343_altered_response_to0.43787598
136MP0009785_altered_susceptibility_to0.43654163
137MP0000462_abnormal_digestive_system0.43531791
138MP0004185_abnormal_adipocyte_glucose0.43407658

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.81184148
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.71796027
3Deep venous thrombosis (HP:0002625)5.70142867
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.64181259
5Xanthomatosis (HP:0000991)4.86135250
6Decreased circulating renin level (HP:0003351)4.41772457
7Gout (HP:0001997)4.41610981
8Hypobetalipoproteinemia (HP:0003563)4.36890895
9Hyperactive renin-angiotensin system (HP:0000841)4.34594052
10Prolonged partial thromboplastin time (HP:0003645)4.33196855
11Hyperammonemia (HP:0001987)4.26534720
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08777160
13Hyperglycinuria (HP:0003108)4.07973869
14Complement deficiency (HP:0004431)4.04693003
15Hyperlipoproteinemia (HP:0010980)4.03721012
16Flat acetabular roof (HP:0003180)4.00530750
17Hypochromic microcytic anemia (HP:0004840)3.87526623
18Ketosis (HP:0001946)3.76042740
19Abnormality of serine family amino acid metabolism (HP:0010894)3.70382444
20Abnormality of glycine metabolism (HP:0010895)3.70382444
21Abnormality of fatty-acid metabolism (HP:0004359)3.61866701
22Hyperglycinemia (HP:0002154)3.57400522
23Joint hemorrhage (HP:0005261)3.50213170
24Hypolipoproteinemia (HP:0010981)3.47542463
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.46661868
26Abnormality of purine metabolism (HP:0004352)3.41016801
27Hypoglycemic coma (HP:0001325)3.39532167
28Fat malabsorption (HP:0002630)3.39463506
29Abnormality of the heme biosynthetic pathway (HP:0010472)3.37604559
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.36826744
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.36235529
32Chronic bronchitis (HP:0004469)3.29561767
33Hypoalphalipoproteinemia (HP:0003233)3.20990310
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.19613388
35Abnormality of nucleobase metabolism (HP:0010932)3.19224068
36Glomerulonephritis (HP:0000099)3.14817102
37Epidermoid cyst (HP:0200040)3.13705866
38Abnormality of the common coagulation pathway (HP:0010990)3.11587043
39Polycythemia (HP:0001901)3.11146928
40Abnormality of dicarboxylic acid metabolism (HP:0010995)3.10467183
41Dicarboxylic aciduria (HP:0003215)3.10467183
42Vascular calcification (HP:0004934)3.07713600
43Abnormality of methionine metabolism (HP:0010901)3.03244951
44Ketoacidosis (HP:0001993)3.02413765
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.97377464
46Abnormal respiratory motile cilium morphology (HP:0005938)2.95578532
47Abnormal respiratory epithelium morphology (HP:0012253)2.95578532
48Increased purine levels (HP:0004368)2.95457402
49Hyperuricemia (HP:0002149)2.95457402
50Metabolic acidosis (HP:0001942)2.92489472
51Abnormality of complement system (HP:0005339)2.90390547
52Alkalosis (HP:0001948)2.89004921
53Hyponatremia (HP:0002902)2.81119732
54Esophageal varix (HP:0002040)2.81064169
55Abnormality of the intrinsic pathway (HP:0010989)2.80847575
56Microcytic anemia (HP:0001935)2.75995422
57Abnormality of pyrimidine metabolism (HP:0004353)2.75638601
58Hyperbilirubinemia (HP:0002904)2.74707213
59Cardiovascular calcification (HP:0011915)2.74046565
60Conjugated hyperbilirubinemia (HP:0002908)2.73476166
61Delayed CNS myelination (HP:0002188)2.69441103
62Abnormal cartilage morphology (HP:0002763)2.67844957
63Hypercholesterolemia (HP:0003124)2.65049286
64Hepatocellular carcinoma (HP:0001402)2.64493375
65Steatorrhea (HP:0002570)2.61828282
66Abnormal respiratory motile cilium physiology (HP:0012261)2.61574045
67Rhinitis (HP:0012384)2.61128336
68Abnormality of chloride homeostasis (HP:0011422)2.60526330
69Lethargy (HP:0001254)2.54679362
70Abnormality of the nasal mucosa (HP:0000433)2.54214868
71Interstitial pulmonary disease (HP:0006530)2.52973975
72Hyperkalemia (HP:0002153)2.52853645
73Right ventricular cardiomyopathy (HP:0011663)2.51225943
74Nephritis (HP:0000123)2.50390187
75Renal salt wasting (HP:0000127)2.42436527
76Generalized aminoaciduria (HP:0002909)2.41523374
77Abnormal ciliary motility (HP:0012262)2.41036388
78Nasal polyposis (HP:0100582)2.39969670
79Spontaneous abortion (HP:0005268)2.39557268
80Malnutrition (HP:0004395)2.39413797
81Spastic diplegia (HP:0001264)2.37684447
82Abdominal distention (HP:0003270)2.36043829
83Vomiting (HP:0002013)2.34901497
84Sparse lateral eyebrow (HP:0005338)2.32575052
85Abnormality of proline metabolism (HP:0010907)2.30049980
86Hydroxyprolinuria (HP:0003080)2.30049980
87Spontaneous hematomas (HP:0007420)2.27919959
88Proximal tubulopathy (HP:0000114)2.27594587
89Abnormality of serum amino acid levels (HP:0003112)2.27533203
90Hypochromic anemia (HP:0001931)2.27171464
91Congenital sensorineural hearing impairment (HP:0008527)2.23717060
92Poikilocytosis (HP:0004447)2.22257826
93Absent/shortened dynein arms (HP:0200106)2.21214241
94Dynein arm defect of respiratory motile cilia (HP:0012255)2.21214241
95Abnormal hemoglobin (HP:0011902)2.20923877
96Abnormality of renin-angiotensin system (HP:0000847)2.19217954
97Hyperaldosteronism (HP:0000859)2.18372386
98Bronchiectasis (HP:0002110)2.18000579
99Abnormality of sodium homeostasis (HP:0010931)2.17803294
100Toxemia of pregnancy (HP:0100603)2.17074462
101Cerebral edema (HP:0002181)2.16583050
102Lip pit (HP:0100267)2.15262928
103Myopathic facies (HP:0002058)2.14819088
104Respiratory distress (HP:0002098)2.11727992
105Tachypnea (HP:0002789)2.11620341
106Systemic lupus erythematosus (HP:0002725)2.11506860
107Myocardial infarction (HP:0001658)2.08913309
108Late onset (HP:0003584)2.08082661
109Abnormality of the fingertips (HP:0001211)2.08069153
110Tubulointerstitial fibrosis (HP:0005576)2.07870738
111Visceral angiomatosis (HP:0100761)2.05582655
112Hypokalemic alkalosis (HP:0001949)2.04260353
113Acanthocytosis (HP:0001927)2.03703252
114Irritability (HP:0000737)2.02921797
115Metabolic alkalosis (HP:0200114)2.01697910
116Abnormal tarsal ossification (HP:0008369)2.01603867
117Abnormality of carpal bone ossification (HP:0006257)2.00417710
118Adrenal overactivity (HP:0002717)1.99666558
119Neonatal onset (HP:0003623)1.99550111
120Sensorimotor neuropathy (HP:0007141)1.99439180
121Glycosuria (HP:0003076)1.98705748
122Abnormality of urine glucose concentration (HP:0011016)1.98705748
123Pancreatitis (HP:0001733)1.98705423
124Pustule (HP:0200039)1.97877610
125Diaphragmatic weakness (HP:0009113)1.97444749
126Reticulocytosis (HP:0001923)1.95961148
127Glomerulosclerosis (HP:0000096)1.95255974
128Neonatal hypoglycemia (HP:0001998)1.94540926
129Ileus (HP:0002595)1.93938241
130Cholelithiasis (HP:0001081)1.93012931
131Hypertriglyceridemia (HP:0002155)1.91310432
132Thin bony cortex (HP:0002753)1.90537360
133Amyloidosis (HP:0011034)1.90424355
134Abnormal gallbladder morphology (HP:0012437)1.89967328
135Rickets (HP:0002748)1.89665744
136Hypotension (HP:0002615)1.88930885
137Abnormality of the gallbladder (HP:0005264)1.88928708
138Skin nodule (HP:0200036)1.87702554
139Abnormal enzyme/coenzyme activity (HP:0012379)1.86534189
140Hemangiomatosis (HP:0007461)1.86223879
141Hemorrhage of the eye (HP:0011885)1.84018971
142Cholecystitis (HP:0001082)1.83813192
143Abnormal gallbladder physiology (HP:0012438)1.83813192
144Cerebral palsy (HP:0100021)1.83576959
145Renal tubular acidosis (HP:0001947)1.81404966
146Growth hormone excess (HP:0000845)1.79665157
147Abnormality of alkaline phosphatase activity (HP:0004379)1.76144225
148Abnormality of potassium homeostasis (HP:0011042)1.75511643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.49690274
2PRKD34.06572373
3MST1R3.96447467
4AKT33.35933948
5ERN13.32469296
6TIE13.09697615
7TAOK32.97865543
8FGFR42.63885805
9SIK12.54563005
10TRIB32.35998595
11TGFBR22.31341517
12EPHB22.21417555
13PKN22.19306619
14SMG12.08232101
15EPHA22.01635994
16FRK1.87526162
17PTK61.84808733
18ICK1.84775271
19PIK3CA1.84536520
20WNK41.77814260
21MYLK1.76112471
22RIPK11.75680939
23TNK21.67090102
24EPHB11.66110463
25EEF2K1.60313181
26MAP3K31.55870080
27ACVR1B1.50904483
28LMTK21.48755888
29MAPKAPK31.45046896
30MAP2K21.44063316
31LRRK21.43197384
32MAP2K31.41798647
33PRKD21.36785975
34EIF2AK11.35440673
35FLT31.34113395
36TYK21.33551839
37MET1.33126514
38NEK91.26318868
39TESK11.23048148
40MAP3K71.22988746
41MAP3K21.21783500
42INSRR1.15208326
43MST41.15049063
44KDR1.14623664
45PIK3CG1.13151959
46TBK11.12704840
47FGFR21.11580695
48MATK1.11121743
49DAPK21.10481818
50PAK41.09525078
51PTK21.05067896
52RIPK41.02970166
53MAPK111.02520771
54ZAP700.98936882
55STK38L0.96330012
56ERBB20.96167236
57FER0.92314144
58ERBB40.91992256
59GRK60.91933187
60PRPF4B0.91374015
61LATS10.90256013
62PDPK10.89097367
63CSK0.88074450
64GRK10.87656449
65MAP2K10.86827408
66PRKAA20.85595760
67RPS6KA20.85010135
68ABL20.84893538
69JAK20.81800390
70TAOK20.81546543
71TGFBR10.80754413
72TRPM70.80581190
73PDK30.79823407
74PDK40.79823407
75OXSR10.77426037
76PRKG20.77310105
77RPS6KB20.75547415
78STK100.75372137
79SGK20.73263140
80HIPK20.70743654
81MAP2K60.68467657
82PINK10.67088529
83SGK4940.66669594
84NEK60.66333339
85MAP2K40.66071656
86CDK60.65134825
87IKBKE0.63681155
88RET0.62886602
89GSK3A0.62789363
90WNK30.62557290
91TEC0.61966520
92MTOR0.60476427
93CAMK1D0.60368751
94PDK20.59939648
95RPS6KL10.59926815
96RPS6KC10.59926815
97PRKCI0.59815610
98MAP3K110.59052977
99CDK90.58943086
100SGK30.57882518
101MAPK150.56092027
102PDGFRA0.55170469
103STK390.54691270
104TTN0.53085467
105PDGFRB0.52630506
106STK240.51710846
107DDR20.51436571
108MARK20.51272504
109JAK10.51246506
110EPHA30.50725947
111MAP3K60.50690369
112STK380.50534152
113FGFR30.48471356
114FGR0.46989512
115MAP3K10.46650748
116PRKACG0.46277101
117RPS6KA60.44891258
118MAPK40.44853856
119MAP3K120.44784945
120CDC42BPA0.44783538
121PRKD10.44781937
122DYRK1B0.44731226
123BRSK20.44603576
124PDK10.43037252
125IGF1R0.42487419
126TAOK10.41596159
127EGFR0.41279902
128KSR20.41191959
129DAPK30.39107548
130IRAK30.38652163
131PRKCZ0.37667091
132PRKAA10.36756395
133MAPK120.36628807
134NEK10.35804109
135ITK0.35789700
136MAPKAPK20.34651765
137SGK2230.34218963
138ILK0.34115845
139YES10.29996329
140BMX0.28975797
141GRK50.28670350
142PAK30.28634287
143CAMKK10.27707799
144MAPK70.26839241

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.48802695
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40504749
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.85778300
4Fatty acid degradation_Homo sapiens_hsa000712.75440645
5Nitrogen metabolism_Homo sapiens_hsa009102.69728759
6Sulfur metabolism_Homo sapiens_hsa009202.65104561
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.62523793
8Tryptophan metabolism_Homo sapiens_hsa003802.62469472
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61158285
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.57125805
11Chemical carcinogenesis_Homo sapiens_hsa052042.52868488
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48313850
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44730995
14Arginine biosynthesis_Homo sapiens_hsa002202.40622030
15Butanoate metabolism_Homo sapiens_hsa006502.22450911
16Propanoate metabolism_Homo sapiens_hsa006402.18915973
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17624278
18Complement and coagulation cascades_Homo sapiens_hsa046102.11227975
19Histidine metabolism_Homo sapiens_hsa003402.09449782
20Peroxisome_Homo sapiens_hsa041462.00298716
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97998840
22Caffeine metabolism_Homo sapiens_hsa002321.94824476
23PPAR signaling pathway_Homo sapiens_hsa033201.88131250
24beta-Alanine metabolism_Homo sapiens_hsa004101.86172802
25Fatty acid metabolism_Homo sapiens_hsa012121.85411395
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84317989
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.79148464
28Retinol metabolism_Homo sapiens_hsa008301.77272010
29Phenylalanine metabolism_Homo sapiens_hsa003601.71459074
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66146093
31Bile secretion_Homo sapiens_hsa049761.59674097
32Pyruvate metabolism_Homo sapiens_hsa006201.50517809
33Selenocompound metabolism_Homo sapiens_hsa004501.50194347
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.48074788
35Tyrosine metabolism_Homo sapiens_hsa003501.44731881
36Sulfur relay system_Homo sapiens_hsa041221.39250233
37Glutathione metabolism_Homo sapiens_hsa004801.38024121
38Carbon metabolism_Homo sapiens_hsa012001.31256540
39Starch and sucrose metabolism_Homo sapiens_hsa005001.29439019
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28214054
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27585302
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27361250
43Fatty acid elongation_Homo sapiens_hsa000621.21744666
44Staphylococcus aureus infection_Homo sapiens_hsa051501.21262289
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.17475056
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17432276
47ABC transporters_Homo sapiens_hsa020101.08836578
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07762736
49Folate biosynthesis_Homo sapiens_hsa007901.05257094
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05159908
51Biosynthesis of amino acids_Homo sapiens_hsa012301.03198958
52Fat digestion and absorption_Homo sapiens_hsa049751.02958159
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01411131
54Arginine and proline metabolism_Homo sapiens_hsa003300.91314892
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.83264708
56Pentose phosphate pathway_Homo sapiens_hsa000300.82046509
57Vitamin digestion and absorption_Homo sapiens_hsa049770.81760539
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79700500
59Glycerolipid metabolism_Homo sapiens_hsa005610.77338555
60Steroid biosynthesis_Homo sapiens_hsa001000.71776417
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67221264
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.63293317
63Fructose and mannose metabolism_Homo sapiens_hsa000510.59956102
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59825378
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57961863
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55353920
67Lysine degradation_Homo sapiens_hsa003100.54507250
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52819183
69Fatty acid biosynthesis_Homo sapiens_hsa000610.52193034
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50662745
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50207121
72Mineral absorption_Homo sapiens_hsa049780.49709340
73Metabolic pathways_Homo sapiens_hsa011000.48748056
74Galactose metabolism_Homo sapiens_hsa000520.45273736
75Collecting duct acid secretion_Homo sapiens_hsa049660.45058126
76Vitamin B6 metabolism_Homo sapiens_hsa007500.44486315
77Thyroid cancer_Homo sapiens_hsa052160.40139292
78Tight junction_Homo sapiens_hsa045300.39346791
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.35021527
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33947201
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31939937
82Sphingolipid metabolism_Homo sapiens_hsa006000.31373703
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.30568776
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30170388
85Vibrio cholerae infection_Homo sapiens_hsa051100.28595214
86Choline metabolism in cancer_Homo sapiens_hsa052310.27625901
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27479509
88Insulin resistance_Homo sapiens_hsa049310.26672415
89Pancreatic secretion_Homo sapiens_hsa049720.26471798
90Endometrial cancer_Homo sapiens_hsa052130.25757348
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25737479
92Insulin signaling pathway_Homo sapiens_hsa049100.24581178
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21220983
94Linoleic acid metabolism_Homo sapiens_hsa005910.18044027
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14933263
96Notch signaling pathway_Homo sapiens_hsa043300.14687370
97One carbon pool by folate_Homo sapiens_hsa006700.14259929
98Arachidonic acid metabolism_Homo sapiens_hsa005900.09790338
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.08781433
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07726218
101Bladder cancer_Homo sapiens_hsa052190.07377861
102Prion diseases_Homo sapiens_hsa050200.06568535
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05979262
104Renin-angiotensin system_Homo sapiens_hsa046140.04242752
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.03963596
106AMPK signaling pathway_Homo sapiens_hsa041520.03412200
107Other glycan degradation_Homo sapiens_hsa005110.00394986
108Hepatitis C_Homo sapiens_hsa051600.00315246
109Pertussis_Homo sapiens_hsa05133-0.0809497
110Parkinsons disease_Homo sapiens_hsa05012-0.0776117
111Amoebiasis_Homo sapiens_hsa05146-0.0708037
112Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0681228
113ECM-receptor interaction_Homo sapiens_hsa04512-0.0640016
114Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0627154
115Lysosome_Homo sapiens_hsa04142-0.0513512
116Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0412818
117Protein digestion and absorption_Homo sapiens_hsa04974-0.0275218
118Glucagon signaling pathway_Homo sapiens_hsa04922-0.0180611
119Oxidative phosphorylation_Homo sapiens_hsa00190-0.0149629

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