SELK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.31230265
2central nervous system myelination (GO:0022010)7.31230265
3fatty acid elongation (GO:0030497)5.95065273
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.15047501
5long-chain fatty acid biosynthetic process (GO:0042759)4.92312816
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.66271666
7presynaptic membrane assembly (GO:0097105)4.41018889
8platelet dense granule organization (GO:0060155)4.23408687
9myelination (GO:0042552)4.23317554
10presynaptic membrane organization (GO:0097090)4.22698866
11ensheathment of neurons (GO:0007272)4.21944859
12axon ensheathment (GO:0008366)4.21944859
13negative regulation of neurotransmitter transport (GO:0051589)4.19260451
14respiratory chain complex IV assembly (GO:0008535)4.12355618
15cholesterol biosynthetic process (GO:0006695)4.06812994
16protein neddylation (GO:0045116)4.00004745
17response to redox state (GO:0051775)3.97174428
18negative regulation of neurotransmitter secretion (GO:0046929)3.96002022
19proteasome assembly (GO:0043248)3.88902406
20DNA deamination (GO:0045006)3.85193377
21water-soluble vitamin biosynthetic process (GO:0042364)3.85139044
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78513892
23protein-cofactor linkage (GO:0018065)3.75948829
24cytochrome complex assembly (GO:0017004)3.74676057
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68916478
26ATP synthesis coupled proton transport (GO:0015986)3.68916478
27substantia nigra development (GO:0021762)3.68458674
28neuron cell-cell adhesion (GO:0007158)3.66601007
29behavioral response to nicotine (GO:0035095)3.66465092
30ATP biosynthetic process (GO:0006754)3.64023002
31dopamine biosynthetic process (GO:0042416)3.61223949
32respiratory electron transport chain (GO:0022904)3.58973849
33sterol biosynthetic process (GO:0016126)3.58783312
34signal peptide processing (GO:0006465)3.55851525
35ER overload response (GO:0006983)3.54457456
36termination of RNA polymerase III transcription (GO:0006386)3.54348328
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.54348328
38electron transport chain (GO:0022900)3.52281156
39nucleotide transmembrane transport (GO:1901679)3.51256798
40chaperone-mediated protein transport (GO:0072321)3.50026726
41cotranslational protein targeting to membrane (GO:0006613)3.49537409
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44844003
43protein targeting to ER (GO:0045047)3.43604071
44oligodendrocyte differentiation (GO:0048709)3.42974490
45sequestering of actin monomers (GO:0042989)3.41550554
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.36236705
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.34285503
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.33461185
49isoprenoid biosynthetic process (GO:0008299)3.32745936
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27188486
51protein localization to endoplasmic reticulum (GO:0070972)3.24763698
52regulation of collateral sprouting (GO:0048670)3.24287087
53glycerophospholipid catabolic process (GO:0046475)3.21568168
54neuron fate determination (GO:0048664)3.19239875
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19087049
56viral transcription (GO:0019083)3.18760613
57nonmotile primary cilium assembly (GO:0035058)3.16032563
58translational termination (GO:0006415)3.15673890
59photoreceptor cell differentiation (GO:0046530)3.15355934
60eye photoreceptor cell differentiation (GO:0001754)3.15355934
61regulation of dopamine metabolic process (GO:0042053)3.10510521
62regulation of catecholamine metabolic process (GO:0042069)3.10510521
63mannosylation (GO:0097502)3.08771412
64amyloid precursor protein metabolic process (GO:0042982)3.00288865
65neuronal action potential propagation (GO:0019227)2.97284579
66GPI anchor biosynthetic process (GO:0006506)2.95959493
67magnesium ion transport (GO:0015693)2.90802126
68negative regulation of protein localization to cell surface (GO:2000009)2.90243195
69intracellular protein transmembrane import (GO:0044743)2.88297845
70cellular ketone body metabolic process (GO:0046950)2.88285654
71long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.88086734
72long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.86850739
73positive regulation of action potential (GO:0045760)2.85914233
74negative regulation of JUN kinase activity (GO:0043508)2.85109247
75protein complex biogenesis (GO:0070271)2.83739147
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83156844
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83156844
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83134787
79ribosomal small subunit assembly (GO:0000028)2.82775641
80positive regulation of oligodendrocyte differentiation (GO:0048714)2.82741582
81energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.81486666
82ATP hydrolysis coupled proton transport (GO:0015991)2.81486666
83epithelial cilium movement (GO:0003351)2.81320051
84regulation of cilium movement (GO:0003352)2.80125460
85regulation of cellular amino acid metabolic process (GO:0006521)2.78806597
86GPI anchor metabolic process (GO:0006505)2.76992754
87ribonucleoside triphosphate biosynthetic process (GO:0009201)2.73429365
88phenol-containing compound catabolic process (GO:0019336)2.73053301
89catechol-containing compound biosynthetic process (GO:0009713)2.72945848
90catecholamine biosynthetic process (GO:0042423)2.72945848
91anterograde synaptic vesicle transport (GO:0048490)2.72727413
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72018527
93response to methylmercury (GO:0051597)2.71060597
94protein localization to mitochondrion (GO:0070585)2.70861423
95establishment of protein localization to mitochondrion (GO:0072655)2.69777842
96translation (GO:0006412)2.69217288
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69203389
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.68557411
99myelin maintenance (GO:0043217)2.67715296
100protein localization to cilium (GO:0061512)2.67111095
101indolalkylamine metabolic process (GO:0006586)2.66982613
102mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66734571
103mitochondrial respiratory chain complex I assembly (GO:0032981)2.66734571
104NADH dehydrogenase complex assembly (GO:0010257)2.66734571
105neural nucleus development (GO:0048857)2.65909834
106protein targeting to mitochondrion (GO:0006626)2.65843219
107apical protein localization (GO:0045176)2.63386606
108transmission of nerve impulse (GO:0019226)2.62501536
109translational elongation (GO:0006414)2.62073373
110neuron remodeling (GO:0016322)2.61295574
111ketone body metabolic process (GO:1902224)2.60259004
112detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59468781
113cytidine metabolic process (GO:0046087)2.58127423
114cytidine catabolic process (GO:0006216)2.58127423
115cytidine deamination (GO:0009972)2.58127423
116negative regulation of execution phase of apoptosis (GO:1900118)2.58001278
117signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.57100453
118signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.57100453
119signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.57100453
120cullin deneddylation (GO:0010388)2.56132645
121negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.55126762
122transferrin transport (GO:0033572)2.54725244
123regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54380287
124response to pheromone (GO:0019236)2.54192785
125hydrogen ion transmembrane transport (GO:1902600)2.53656494
126intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.53320944
127signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.53320944
128L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52594796
129mitochondrial transport (GO:0006839)2.52222471
130regulation of hexokinase activity (GO:1903299)2.51751853
131regulation of glucokinase activity (GO:0033131)2.51751853
132positive regulation of cellular amine metabolic process (GO:0033240)2.51555310
133neurotransmitter uptake (GO:0001504)2.49955890
134negative regulation of ligase activity (GO:0051352)2.49348169
135negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49348169
136indole-containing compound catabolic process (GO:0042436)2.48974224
137indolalkylamine catabolic process (GO:0046218)2.48974224
138tryptophan catabolic process (GO:0006569)2.48974224
139oxidative phosphorylation (GO:0006119)2.48764062
140limb bud formation (GO:0060174)2.47848271
141proton transport (GO:0015992)2.47806275
142membrane assembly (GO:0071709)2.46446657
143phagosome maturation (GO:0090382)2.45926274
144fatty-acyl-CoA metabolic process (GO:0035337)2.45700682
145regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45530321
146nucleoside triphosphate biosynthetic process (GO:0009142)2.45463586
147preassembly of GPI anchor in ER membrane (GO:0016254)2.44290581
148cranial nerve development (GO:0021545)2.42579762
149cellular response to epinephrine stimulus (GO:0071872)2.42422585
150hydrogen transport (GO:0006818)2.42205146
151amyloid precursor protein catabolic process (GO:0042987)2.40283859
152GTP biosynthetic process (GO:0006183)2.40116754
153inner mitochondrial membrane organization (GO:0007007)2.39566816
154response to epinephrine (GO:0071871)2.39067957
155virion attachment to host cell (GO:0019062)2.38930183
156adhesion of symbiont to host cell (GO:0044650)2.38930183
157signal transduction involved in cell cycle checkpoint (GO:0072395)2.38879813
158signal transduction involved in DNA integrity checkpoint (GO:0072401)2.38017075
159signal transduction involved in DNA damage checkpoint (GO:0072422)2.38017075
160asymmetric protein localization (GO:0008105)2.37234837
161viral life cycle (GO:0019058)2.36606848
162establishment of mitochondrion localization (GO:0051654)2.36046186
163fatty-acyl-CoA biosynthetic process (GO:0046949)2.35897372
164negative regulation of exocytosis (GO:0045920)2.35470489
165peptidyl-histidine modification (GO:0018202)2.35289892
166trivalent inorganic cation transport (GO:0072512)2.35095096
167ferric iron transport (GO:0015682)2.35095096
168DNA damage response, detection of DNA damage (GO:0042769)2.34648244
169mitochondrial respiratory chain complex assembly (GO:0033108)2.34561264
170peptidyl-tyrosine autophosphorylation (GO:0038083)2.34549961
171mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.33720334
172cerebral cortex radially oriented cell migration (GO:0021799)2.32932611
173pH reduction (GO:0045851)2.32432487
174peripheral nervous system development (GO:0007422)2.32147957
175adult walking behavior (GO:0007628)2.30933654
176negative regulation of acute inflammatory response (GO:0002674)2.30022759
177negative regulation of synaptic transmission, GABAergic (GO:0032229)2.29909745
178calcium-mediated signaling using intracellular calcium source (GO:0035584)2.29325560
179neurotransmitter catabolic process (GO:0042135)2.28732103
180postsynaptic membrane organization (GO:0001941)2.27875636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79948877
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.70782805
3GBX2_23144817_ChIP-Seq_PC3_Human3.53637539
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.36400532
5* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01885529
6EZH2_22144423_ChIP-Seq_EOC_Human2.97813820
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77064380
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.74134035
9TAF15_26573619_Chip-Seq_HEK293_Human2.66391450
10ZNF274_21170338_ChIP-Seq_K562_Hela2.58515826
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53386492
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40809612
13VDR_22108803_ChIP-Seq_LS180_Human2.40543272
14ELK1_19687146_ChIP-ChIP_HELA_Human2.38402759
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29651136
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15751931
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.14355507
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07505588
19VDR_23849224_ChIP-Seq_CD4+_Human2.06705024
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04875046
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04413154
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02210100
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.01904286
24EWS_26573619_Chip-Seq_HEK293_Human1.99145245
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98863306
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.96000379
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95961049
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95135965
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91815950
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.89212996
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88979144
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85415384
33ER_23166858_ChIP-Seq_MCF-7_Human1.75144274
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74303174
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73899597
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72813186
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72719341
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70811959
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70801348
40P300_19829295_ChIP-Seq_ESCs_Human1.70391109
41* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67496800
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.66210883
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62841692
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61488033
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61488033
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60152913
47MYC_18940864_ChIP-ChIP_HL60_Human1.59935312
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57783773
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56685829
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.56098050
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.55008781
52FUS_26573619_Chip-Seq_HEK293_Human1.54885503
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54616191
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52258940
55* SRF_21415370_ChIP-Seq_HL-1_Mouse1.49523426
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49119970
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46826576
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.44378612
59FOXP3_21729870_ChIP-Seq_TREG_Human1.42626725
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42137762
61TP53_22573176_ChIP-Seq_HFKS_Human1.42072785
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.40632369
63AR_21572438_ChIP-Seq_LNCaP_Human1.39560108
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35775807
65* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35526849
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35160822
67* REST_21632747_ChIP-Seq_MESCs_Mouse1.34574829
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34512904
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33946248
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.33144528
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.32864493
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31743445
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.31508611
74BCAT_22108803_ChIP-Seq_LS180_Human1.30010422
75IGF1R_20145208_ChIP-Seq_DFB_Human1.29315109
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28918513
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.27701544
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27502282
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26498801
80SMAD4_21799915_ChIP-Seq_A2780_Human1.26365861
81RNF2_27304074_Chip-Seq_NSC_Mouse1.25914383
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25586105
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24443556
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23343975
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23343975
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22726267
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.22542965
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20561696
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.20438305
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19053760
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17360554
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17135946
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.17135946
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.15904304
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15316484
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14873639
97CBP_20019798_ChIP-Seq_JUKART_Human1.14394732
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14394732
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13929826
100P53_22387025_ChIP-Seq_ESCs_Mouse1.13706324
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13655303
102* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12452174
103AR_25329375_ChIP-Seq_VCAP_Human1.12304411
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.12201850
105P300_18555785_Chip-Seq_ESCs_Mouse1.10546217
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10076003
107HTT_18923047_ChIP-ChIP_STHdh_Human1.09457146
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09052049
109REST_18959480_ChIP-ChIP_MESCs_Mouse1.08147458
110EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06966337
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06286473
112AR_20517297_ChIP-Seq_VCAP_Human1.05431941
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.04461467
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.03495918
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03096294
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02960897
117ELK1_22589737_ChIP-Seq_MCF10A_Human1.02936122
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02770948
119JUN_21703547_ChIP-Seq_K562_Human1.01787507
120TCF4_22108803_ChIP-Seq_LS180_Human1.01423090
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.00414843
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.00318257
123RUNX2_22187159_ChIP-Seq_PCA_Human1.00154562
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99915935
125FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99480496
126SOX2_19829295_ChIP-Seq_ESCs_Human0.99282404
127NANOG_19829295_ChIP-Seq_ESCs_Human0.99282404
128NCOR_22424771_ChIP-Seq_293T_Human0.99166648
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97986255
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97777209
131NMYC_18555785_Chip-Seq_ESCs_Mouse0.96625552
132FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96333530
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.96108075
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95944310
135SMAD1_18555785_Chip-Seq_ESCs_Mouse0.95683554
136STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95651593
137KDM2B_26808549_Chip-Seq_REH_Human0.95362654
138AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95120024
139STAT3_23295773_ChIP-Seq_U87_Human0.95082835
140IRF1_19129219_ChIP-ChIP_H3396_Human0.94631128
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94030728
142BP1_19119308_ChIP-ChIP_Hs578T_Human0.90407134
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90132057
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89850784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.12592920
2MP0000920_abnormal_myelination3.32643521
3MP0001905_abnormal_dopamine_level3.09871928
4MP0001529_abnormal_vocalization3.05585140
5MP0004270_analgesia3.01893581
6MP0005171_absent_coat_pigmentation2.52709555
7MP0002272_abnormal_nervous_system2.41796657
8MP0003011_delayed_dark_adaptation2.41744698
9MP0002102_abnormal_ear_morphology2.34941746
10MP0002064_seizures2.25291139
11MP0003136_yellow_coat_color2.25122656
12MP0002734_abnormal_mechanical_nocicepti2.17267067
13MP0005084_abnormal_gallbladder_morpholo2.10540538
14MP0006276_abnormal_autonomic_nervous2.07260691
15MP0009745_abnormal_behavioral_response2.06931230
16MP0010386_abnormal_urinary_bladder2.02574348
17MP0004142_abnormal_muscle_tone1.99843755
18MP0004742_abnormal_vestibular_system1.99814495
19MP0008877_abnormal_DNA_methylation1.97293167
20MP0004043_abnormal_pH_regulation1.97182106
21MP0001486_abnormal_startle_reflex1.96582534
22MP0005379_endocrine/exocrine_gland_phen1.95288171
23MP0002277_abnormal_respiratory_mucosa1.92786075
24MP0009046_muscle_twitch1.87971385
25MP0003787_abnormal_imprinting1.87821961
26MP0003635_abnormal_synaptic_transmissio1.87460685
27MP0003690_abnormal_glial_cell1.81774578
28MP0002572_abnormal_emotion/affect_behav1.78146172
29MP0006292_abnormal_olfactory_placode1.77143217
30MP0000569_abnormal_digit_pigmentation1.75398299
31MP0005409_darkened_coat_color1.74546795
32MP0008875_abnormal_xenobiotic_pharmacok1.71462083
33MP0001970_abnormal_pain_threshold1.69803919
34MP0001986_abnormal_taste_sensitivity1.69154670
35MP0003186_abnormal_redox_activity1.68177613
36MP0003634_abnormal_glial_cell1.67777376
37MP0000778_abnormal_nervous_system1.65839788
38MP0001968_abnormal_touch/_nociception1.64614608
39MP0003329_amyloid_beta_deposits1.62655402
40MP0001440_abnormal_grooming_behavior1.62228152
41MP0002735_abnormal_chemical_nociception1.61319848
42MP0002733_abnormal_thermal_nociception1.59495324
43MP0002638_abnormal_pupillary_reflex1.56957618
44MP0003195_calcinosis1.55941993
45MP0002822_catalepsy1.55909376
46MP0005645_abnormal_hypothalamus_physiol1.55413936
47MP0005423_abnormal_somatic_nervous1.53533194
48MP0005646_abnormal_pituitary_gland1.53486983
49MP0008872_abnormal_physiological_respon1.52661249
50MP0002736_abnormal_nociception_after1.52359479
51MP0001485_abnormal_pinna_reflex1.50751312
52MP0002653_abnormal_ependyma_morphology1.50525531
53MP0001188_hyperpigmentation1.49924605
54MP0004859_abnormal_synaptic_plasticity1.49105415
55MP0006036_abnormal_mitochondrial_physio1.48796261
56MP0002063_abnormal_learning/memory/cond1.48357233
57MP0003283_abnormal_digestive_organ1.46532744
58MP0001501_abnormal_sleep_pattern1.44837957
59MP0002229_neurodegeneration1.43677731
60MP0003950_abnormal_plasma_membrane1.43052399
61MP0000372_irregular_coat_pigmentation1.42632555
62MP0002067_abnormal_sensory_capabilities1.40587112
63MP0008789_abnormal_olfactory_epithelium1.39974553
64MP0006072_abnormal_retinal_apoptosis1.37391182
65MP0002837_dystrophic_cardiac_calcinosis1.36451383
66MP0003806_abnormal_nucleotide_metabolis1.36248885
67MP0002163_abnormal_gland_morphology1.35572610
68MP0005551_abnormal_eye_electrophysiolog1.34906322
69MP0001984_abnormal_olfaction1.30755369
70MP0005386_behavior/neurological_phenoty1.30122065
71MP0004924_abnormal_behavior1.30122065
72MP0008058_abnormal_DNA_repair1.26506142
73MP0004885_abnormal_endolymph1.26229090
74MP0008260_abnormal_autophagy1.24709237
75MP0002876_abnormal_thyroid_physiology1.23295183
76MP0000013_abnormal_adipose_tissue1.21944757
77MP0004381_abnormal_hair_follicle1.21056751
78MP0001963_abnormal_hearing_physiology1.18828590
79MP0009780_abnormal_chondrocyte_physiolo1.17660421
80MP0001502_abnormal_circadian_rhythm1.15350205
81MP0002882_abnormal_neuron_morphology1.15046801
82MP0000955_abnormal_spinal_cord1.14945840
83MP0008995_early_reproductive_senescence1.13140325
84MP0002928_abnormal_bile_duct1.12810320
85MP0005410_abnormal_fertilization1.12647617
86MP0003183_abnormal_peptide_metabolism1.11302152
87MP0002184_abnormal_innervation1.10567309
88MP0002066_abnormal_motor_capabilities/c1.10025443
89MP0002909_abnormal_adrenal_gland1.09143355
90MP0003632_abnormal_nervous_system1.09027659
91MP0002557_abnormal_social/conspecific_i1.08300468
92MP0001919_abnormal_reproductive_system1.08112964
93MP0004133_heterotaxia1.07941905
94MP0005408_hypopigmentation1.07464493
95MP0002095_abnormal_skin_pigmentation1.05421733
96MP0000462_abnormal_digestive_system1.05003553
97MP0004134_abnormal_chest_morphology1.03993325
98MP0003631_nervous_system_phenotype1.01626525
99MP0003121_genomic_imprinting1.01286267
100MP0004215_abnormal_myocardial_fiber1.00336155
101MP0008569_lethality_at_weaning0.99942568
102MP0005671_abnormal_response_to0.99284871
103MP0002752_abnormal_somatic_nervous0.98297829
104MP0009379_abnormal_foot_pigmentation0.97922252
105MP0001764_abnormal_homeostasis0.97841939
106MP0001664_abnormal_digestion0.97655865
107MP0005389_reproductive_system_phenotype0.95991747
108MP0006035_abnormal_mitochondrial_morpho0.95509694
109MP0001944_abnormal_pancreas_morphology0.95229852
110MP0003633_abnormal_nervous_system0.95224580
111MP0003122_maternal_imprinting0.94147605
112MP0005174_abnormal_tail_pigmentation0.93733778
113MP0005253_abnormal_eye_physiology0.93586596
114MP0004145_abnormal_muscle_electrophysio0.93030754
115MP0003718_maternal_effect0.92727964
116MP0000026_abnormal_inner_ear0.91614715
117MP0003786_premature_aging0.91302597
118MP0000631_abnormal_neuroendocrine_gland0.90419203
119MP0002938_white_spotting0.88696992
120MP0005499_abnormal_olfactory_system0.87307182
121MP0005394_taste/olfaction_phenotype0.87307182
122MP0005332_abnormal_amino_acid0.85242095
123MP0001661_extended_life_span0.84833801
124MP0003646_muscle_fatigue0.84082186
125MP0002295_abnormal_pulmonary_circulatio0.83706625
126MP0002751_abnormal_autonomic_nervous0.82052880
127MP0002234_abnormal_pharynx_morphology0.81958743
128MP0005636_abnormal_mineral_homeostasis0.81506937
129MP0003137_abnormal_impulse_conducting0.81205465
130MP0001324_abnormal_eye_pigmentation0.78137120
131MP0002148_abnormal_hypersensitivity_rea0.74876911
132MP0005535_abnormal_body_temperature0.72844479
133MP0009785_altered_susceptibility_to0.72697021
134MP0002090_abnormal_vision0.72465990
135MP0005058_abnormal_lysosome_morphology0.72195830
136MP0002693_abnormal_pancreas_physiology0.71609242
137MP0000604_amyloidosis0.70652363
138MP0001346_abnormal_lacrimal_gland0.70084428
139MP0005195_abnormal_posterior_eye0.69271540
140MP0001299_abnormal_eye_distance/0.68916260
141MP0005451_abnormal_body_composition0.68166402
142MP0005310_abnormal_salivary_gland0.67984632
143MP0001542_abnormal_bone_strength0.64497008
144MP0004147_increased_porphyrin_level0.63503756

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.49562408
2Parakeratosis (HP:0001036)4.18641448
3Neurofibrillary tangles (HP:0002185)4.05230354
4Degeneration of the lateral corticospinal tracts (HP:0002314)3.90894459
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.90894459
6Abnormal mitochondria in muscle tissue (HP:0008316)3.90110067
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.88714922
8Mitochondrial inheritance (HP:0001427)3.86954817
9Hypothermia (HP:0002045)3.83425346
10Progressive macrocephaly (HP:0004481)3.74253811
11Acute encephalopathy (HP:0006846)3.60924538
12Renal Fanconi syndrome (HP:0001994)3.59849100
13Pancreatic cysts (HP:0001737)3.52051802
14Abnormality of midbrain morphology (HP:0002418)3.40084701
15Molar tooth sign on MRI (HP:0002419)3.40084701
16Sensory axonal neuropathy (HP:0003390)3.35997320
17Pancreatic fibrosis (HP:0100732)3.34222973
18True hermaphroditism (HP:0010459)3.29220343
19Leukodystrophy (HP:0002415)3.16527604
20Pheochromocytoma (HP:0002666)3.14271456
21Hepatocellular necrosis (HP:0001404)3.11702266
22Increased hepatocellular lipid droplets (HP:0006565)3.04998772
23Neuroendocrine neoplasm (HP:0100634)3.02620951
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97801538
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97801538
26Increased CSF lactate (HP:0002490)2.97103641
27Increased serum pyruvate (HP:0003542)2.91661067
28Abnormality of glycolysis (HP:0004366)2.91661067
29Limb dystonia (HP:0002451)2.87775609
30Peripheral hypomyelination (HP:0007182)2.84795494
31Retinal dysplasia (HP:0007973)2.84402080
32Congenital, generalized hypertrichosis (HP:0004540)2.82845349
33Nephronophthisis (HP:0000090)2.75020437
34Cerebral inclusion bodies (HP:0100314)2.74219819
35Atonic seizures (HP:0010819)2.71251923
36Abnormality of the corticospinal tract (HP:0002492)2.70820038
37Methylmalonic aciduria (HP:0012120)2.67392898
38Congenital stationary night blindness (HP:0007642)2.65510809
39Congenital ichthyosiform erythroderma (HP:0007431)2.65384469
40Medial flaring of the eyebrow (HP:0010747)2.63109657
41Lipid accumulation in hepatocytes (HP:0006561)2.61383655
42Hepatic necrosis (HP:0002605)2.61188788
43Optic disc pallor (HP:0000543)2.58483061
44Abnormality of renal resorption (HP:0011038)2.54235188
45Abnormality of the renal cortex (HP:0011035)2.51730836
46Cerebral hypomyelination (HP:0006808)2.50667320
473-Methylglutaconic aciduria (HP:0003535)2.50440951
48Myokymia (HP:0002411)2.47195069
49Increased serum lactate (HP:0002151)2.47059330
50Abnormal number of erythroid precursors (HP:0012131)2.45623807
51Vaginal atresia (HP:0000148)2.43273260
52Focal motor seizures (HP:0011153)2.41860880
53Genital tract atresia (HP:0001827)2.41504529
54Supranuclear gaze palsy (HP:0000605)2.38451921
55Glycosuria (HP:0003076)2.38270971
56Abnormality of urine glucose concentration (HP:0011016)2.38270971
57Patchy hypopigmentation of hair (HP:0011365)2.36720911
58Gait imbalance (HP:0002141)2.36033104
59Renal cortical cysts (HP:0000803)2.34151559
60Generalized aminoaciduria (HP:0002909)2.34103589
61Abnormality of the renal medulla (HP:0100957)2.28976714
62Increased muscle lipid content (HP:0009058)2.28836638
63Abnormality of cells of the erythroid lineage (HP:0012130)2.26911225
64Large for gestational age (HP:0001520)2.25902617
65Congenital primary aphakia (HP:0007707)2.22553785
66Abnormal hair whorl (HP:0010721)2.22322857
67Cerebral hemorrhage (HP:0001342)2.22173526
68Autoamputation (HP:0001218)2.21555784
69Methylmalonic acidemia (HP:0002912)2.20586615
70White forelock (HP:0002211)2.18646705
71Abnormal pupillary function (HP:0007686)2.18361826
72Lethargy (HP:0001254)2.18220984
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17751288
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15816311
75Respiratory failure (HP:0002878)2.15543459
76Macrocytic anemia (HP:0001972)2.14425140
77Epileptic encephalopathy (HP:0200134)2.14293123
78Cerebral edema (HP:0002181)2.12172219
79Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10647339
80Alacrima (HP:0000522)2.10423323
81Sclerocornea (HP:0000647)2.09827817
82Abnormal ciliary motility (HP:0012262)2.08300568
83Akinesia (HP:0002304)2.07974958
84Nephrogenic diabetes insipidus (HP:0009806)2.07078909
85Hypomagnesemia (HP:0002917)2.03349221
86Split foot (HP:0001839)2.02524103
87Thickened helices (HP:0000391)2.02292110
88Hyperventilation (HP:0002883)2.01346924
89Abnormality of vitamin B metabolism (HP:0004340)2.00674413
90Stomatitis (HP:0010280)1.99372323
91Increased intramyocellular lipid droplets (HP:0012240)1.98513159
92Pendular nystagmus (HP:0012043)1.96662211
93Abnormal rod and cone electroretinograms (HP:0008323)1.95560920
94Aplasia/hypoplasia of the uterus (HP:0008684)1.95531731
95Absent/shortened dynein arms (HP:0200106)1.94193308
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.94193308
97X-linked dominant inheritance (HP:0001423)1.93818913
98Hypoglycemic coma (HP:0001325)1.93180560
99Abolished electroretinogram (ERG) (HP:0000550)1.92884143
100Male pseudohermaphroditism (HP:0000037)1.92874064
101Spastic gait (HP:0002064)1.89379414
102Septo-optic dysplasia (HP:0100842)1.88528717
103CNS demyelination (HP:0007305)1.88489167
104Abnormal autonomic nervous system physiology (HP:0012332)1.88325063
105Furrowed tongue (HP:0000221)1.86570274
106Respiratory difficulties (HP:0002880)1.85218655
107Dysmetria (HP:0001310)1.84959303
108Exercise intolerance (HP:0003546)1.83937256
109Spastic paraparesis (HP:0002313)1.81638582
110Onion bulb formation (HP:0003383)1.81136231
111Dicarboxylic aciduria (HP:0003215)1.80942659
112Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80942659
113Scanning speech (HP:0002168)1.80024431
114Concave nail (HP:0001598)1.78903032
115Anencephaly (HP:0002323)1.78555945
116Optic nerve hypoplasia (HP:0000609)1.78264806
117Type I transferrin isoform profile (HP:0003642)1.77481942
118Polydipsia (HP:0001959)1.77088375
119Abnormal drinking behavior (HP:0030082)1.77088375
120Abnormality of the labia minora (HP:0012880)1.77047935
121Abnormal respiratory motile cilium physiology (HP:0012261)1.77041211
122Exertional dyspnea (HP:0002875)1.76628869
123Lactic acidosis (HP:0003128)1.75279963
124Aplasia/Hypoplasia of the lens (HP:0008063)1.74515388
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.73894838
126Hypoplastic pelvis (HP:0008839)1.73805490
127Congenital sensorineural hearing impairment (HP:0008527)1.73489877
128Cystic liver disease (HP:0006706)1.72291853
129Chronic hepatic failure (HP:0100626)1.71452822
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70285432
131Hemiparesis (HP:0001269)1.70156924
132Abnormality of the vitamin B12 metabolism (HP:0004341)1.69754676
133Decreased central vision (HP:0007663)1.69421286
134Bile duct proliferation (HP:0001408)1.68975386
135Abnormal biliary tract physiology (HP:0012439)1.68975386
136Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68061961
137Increased circulating renin level (HP:0000848)1.67586271
138CNS hypomyelination (HP:0003429)1.67282235
139Abnormal respiratory motile cilium morphology (HP:0005938)1.66920447
140Abnormal respiratory epithelium morphology (HP:0012253)1.66920447
141Esotropia (HP:0000565)1.66850010
142Decreased lacrimation (HP:0000633)1.65796076
143Abnormality of alanine metabolism (HP:0010916)1.65745335
144Hyperalaninemia (HP:0003348)1.65745335
145Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65745335
146Abnormality of magnesium homeostasis (HP:0004921)1.65453515
147Abnormality of calcium-phosphate metabolism (HP:0100530)1.65235633
148Tubular atrophy (HP:0000092)1.64813514
149Progressive neurologic deterioration (HP:0002344)1.64738828
150Short tibia (HP:0005736)1.64400994
151Slow saccadic eye movements (HP:0000514)1.64331714
152Type II lissencephaly (HP:0007260)1.64194980
153Progressive inability to walk (HP:0002505)1.63958127
154Cupped ear (HP:0000378)1.63580320
155Abnormal urine phosphate concentration (HP:0012599)1.63456542
156Anteriorly placed anus (HP:0001545)1.61845699
157Hyperphosphaturia (HP:0003109)1.61561083
158Barrel-shaped chest (HP:0001552)1.60545035
159Clumsiness (HP:0002312)1.60263034
160Poor speech (HP:0002465)1.59609453

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.57335479
2CASK3.51976769
3OXSR13.41703399
4FRK2.76276052
5BCR2.58293438
6WNK42.48428276
7ZAK2.41943664
8TNIK2.31445950
9VRK22.28242101
10MAP4K22.27133554
11MST42.24889147
12PBK2.24088496
13MAPKAPK52.14347402
14TXK1.93712982
15MAPK151.91191007
16CDK191.89986408
17TLK11.84894949
18NUAK11.83446657
19LIMK11.81326576
20BMPR1B1.78335259
21ARAF1.76995603
22PKN11.72710802
23EPHB11.67647092
24STK161.67403382
25NTRK11.66543376
26GRK71.63158341
27UHMK11.57170959
28INSRR1.54371439
29CSNK1G31.53363847
30PINK11.50005240
31BCKDK1.47919084
32PNCK1.46565744
33BUB11.45865369
34MUSK1.44249535
35NEK61.43848735
36CAMK2B1.42401098
37PRPF4B1.40555433
38MET1.32105390
39TSSK61.30778348
40MAP3K121.28571036
41ADRBK21.28431489
42GRK51.28257730
43BMPR21.26851884
44NME11.25550198
45CAMK2D1.23792788
46MAP2K71.21308879
47SRPK11.20890952
48FGR1.19780834
49WNK11.18158034
50WEE11.18072237
51TAOK31.16902256
52CSNK1G21.15343424
53CSNK1G11.13475763
54PRKCE1.12861383
55CSNK1A1L1.11495698
56PLK31.08603933
57MKNK21.07027985
58TRIM281.05892605
59DYRK21.04941476
60BRSK21.03095875
61MAPK131.02789905
62CAMK2A0.99048561
63EPHA40.98176392
64SGK4940.97693813
65SGK2230.97693813
66IRAK10.96805228
67NTRK30.94909393
68IRAK20.94256924
69MARK10.91860359
70CAMK2G0.91790832
71ROCK20.89713723
72OBSCN0.89567298
73ERBB30.86607262
74TIE10.85941337
75PLK20.85456487
76ACVR1B0.80121899
77PASK0.79047390
78ERBB40.77286033
79PDK20.76000181
80CDK50.73946836
81PAK30.71521737
82AKT30.71028693
83TESK20.70950986
84MKNK10.70297285
85PRKCQ0.70234389
86FGFR20.69393084
87CDK80.67704414
88STK38L0.67073509
89IKBKB0.66600031
90MAP2K60.65900477
91BRAF0.65577699
92DYRK30.65252622
93EIF2AK10.65071253
94NEK10.64779078
95ADRBK10.64456319
96WNK30.62819805
97CDK140.62343351
98IKBKE0.61749733
99DAPK20.61479103
100IRAK40.61065800
101PLK40.60716223
102VRK10.59648597
103MAP3K40.59097260
104EIF2AK30.57260468
105NTRK20.56634541
106MYLK0.56625509
107MAP3K20.56435744
108CDK30.53223021
109CCNB10.50199214
110RPS6KA50.49493389
111HIPK20.49127454
112PRKACA0.48572085
113DYRK1A0.48332103
114CDC70.47683944
115PRKCG0.47599986
116CDK180.47203767
117FES0.45670110
118PRKG10.45535216
119CDK150.45080025
120CSNK2A10.44982734
121CSNK1A10.43892964
122TEC0.43665582
123ABL20.43566761
124PHKG10.42720019
125PHKG20.42720019
126CSNK2A20.42103260
127GRK10.42057958
128SIK30.41947058
129CDK11A0.41364791
130MINK10.40805101
131PLK10.40449739
132ITK0.39482188
133PAK60.36706490
134MAP2K20.35038012
135PIK3CG0.34622410
136PTK2B0.34552772
137PIM20.32527857
138FYN0.32133994
139CLK10.32066490
140RIPK40.30224571
141PIK3CA0.29274337
142YES10.28214070
143MARK20.28035997
144CAMKK20.27071620

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.26273459
2Oxidative phosphorylation_Homo sapiens_hsa001904.20088826
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.94570462
4Ribosome_Homo sapiens_hsa030103.31267080
5Steroid biosynthesis_Homo sapiens_hsa001003.21757872
6Fatty acid elongation_Homo sapiens_hsa000623.17098667
7Parkinsons disease_Homo sapiens_hsa050123.14510872
8Collecting duct acid secretion_Homo sapiens_hsa049662.67062917
9Alzheimers disease_Homo sapiens_hsa050102.60592170
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47695542
11Sulfur metabolism_Homo sapiens_hsa009202.40834576
12Vibrio cholerae infection_Homo sapiens_hsa051102.28995056
13Ether lipid metabolism_Homo sapiens_hsa005652.10775337
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02113493
15Huntingtons disease_Homo sapiens_hsa050161.97454116
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93816578
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.72646100
18Serotonergic synapse_Homo sapiens_hsa047261.63458356
19Rheumatoid arthritis_Homo sapiens_hsa053231.62656598
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.62084206
21Synaptic vesicle cycle_Homo sapiens_hsa047211.60706188
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60035321
23Sphingolipid metabolism_Homo sapiens_hsa006001.58248029
24Caffeine metabolism_Homo sapiens_hsa002321.53861241
25Proteasome_Homo sapiens_hsa030501.48771950
26Homologous recombination_Homo sapiens_hsa034401.48266870
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44140055
28Nitrogen metabolism_Homo sapiens_hsa009101.40541802
29GABAergic synapse_Homo sapiens_hsa047271.30528600
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28199137
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25415183
32Nicotine addiction_Homo sapiens_hsa050331.24301377
33RNA degradation_Homo sapiens_hsa030181.23136297
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21357438
35Cocaine addiction_Homo sapiens_hsa050301.20296753
36Linoleic acid metabolism_Homo sapiens_hsa005911.16966681
37Tryptophan metabolism_Homo sapiens_hsa003801.16898011
38Cardiac muscle contraction_Homo sapiens_hsa042601.16123723
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16115748
40Histidine metabolism_Homo sapiens_hsa003401.12782876
41Phagosome_Homo sapiens_hsa041451.07399067
42Glutamatergic synapse_Homo sapiens_hsa047241.07057545
43Morphine addiction_Homo sapiens_hsa050321.06683813
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03006069
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.96870655
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96443924
47Taste transduction_Homo sapiens_hsa047420.96015535
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95944144
49Mismatch repair_Homo sapiens_hsa034300.95083296
50Nucleotide excision repair_Homo sapiens_hsa034200.94157267
51Amphetamine addiction_Homo sapiens_hsa050310.93055858
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92952905
53Dopaminergic synapse_Homo sapiens_hsa047280.91054944
54Regulation of autophagy_Homo sapiens_hsa041400.90460689
55Butanoate metabolism_Homo sapiens_hsa006500.90404751
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90373400
57Fanconi anemia pathway_Homo sapiens_hsa034600.90320996
58Circadian entrainment_Homo sapiens_hsa047130.88889096
59Insulin secretion_Homo sapiens_hsa049110.88423805
60Autoimmune thyroid disease_Homo sapiens_hsa053200.87725634
61Long-term depression_Homo sapiens_hsa047300.87461437
62Chemical carcinogenesis_Homo sapiens_hsa052040.86480068
63Axon guidance_Homo sapiens_hsa043600.86256753
64Purine metabolism_Homo sapiens_hsa002300.83059316
65Phototransduction_Homo sapiens_hsa047440.82219698
66Arachidonic acid metabolism_Homo sapiens_hsa005900.82069873
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.80835967
68Spliceosome_Homo sapiens_hsa030400.80833855
69Pyrimidine metabolism_Homo sapiens_hsa002400.79817830
70Selenocompound metabolism_Homo sapiens_hsa004500.76496818
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75389875
72Tyrosine metabolism_Homo sapiens_hsa003500.75292776
73Cholinergic synapse_Homo sapiens_hsa047250.74496825
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73082148
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72344784
76Type I diabetes mellitus_Homo sapiens_hsa049400.71289342
77Circadian rhythm_Homo sapiens_hsa047100.68838400
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68756156
79Lysosome_Homo sapiens_hsa041420.68723692
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68455102
81RNA polymerase_Homo sapiens_hsa030200.65814084
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62720777
83Graft-versus-host disease_Homo sapiens_hsa053320.59666590
84Retinol metabolism_Homo sapiens_hsa008300.59432194
85Vitamin B6 metabolism_Homo sapiens_hsa007500.57696363
86Metabolic pathways_Homo sapiens_hsa011000.57440329
87Arginine and proline metabolism_Homo sapiens_hsa003300.56118152
88Pancreatic secretion_Homo sapiens_hsa049720.55593964
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54620777
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53032831
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.52543856
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52364642
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51466459
94Asthma_Homo sapiens_hsa053100.48600356
95One carbon pool by folate_Homo sapiens_hsa006700.48473140
96Salivary secretion_Homo sapiens_hsa049700.48222863
97Renin secretion_Homo sapiens_hsa049240.46726706
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46100614
99Allograft rejection_Homo sapiens_hsa053300.46033797
100Olfactory transduction_Homo sapiens_hsa047400.42911896
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42640491
102Ovarian steroidogenesis_Homo sapiens_hsa049130.41249072
103Primary immunodeficiency_Homo sapiens_hsa053400.40645347
104Phenylalanine metabolism_Homo sapiens_hsa003600.40167149
105Folate biosynthesis_Homo sapiens_hsa007900.39805091
106Other glycan degradation_Homo sapiens_hsa005110.38638618
107Sulfur relay system_Homo sapiens_hsa041220.38197416
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.38168762
109RNA transport_Homo sapiens_hsa030130.37365196
110Ras signaling pathway_Homo sapiens_hsa040140.37109123
111Long-term potentiation_Homo sapiens_hsa047200.37032877
112beta-Alanine metabolism_Homo sapiens_hsa004100.36524110
113Peroxisome_Homo sapiens_hsa041460.36121380
114Basal transcription factors_Homo sapiens_hsa030220.32947620
115Glutathione metabolism_Homo sapiens_hsa004800.32283409
116Pyruvate metabolism_Homo sapiens_hsa006200.31712017
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31465936
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31286663
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30885413
120Calcium signaling pathway_Homo sapiens_hsa040200.30559776
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.30346792
122Prion diseases_Homo sapiens_hsa050200.29767741
123Renal cell carcinoma_Homo sapiens_hsa052110.29604879
124Fatty acid degradation_Homo sapiens_hsa000710.29222161
125Vitamin digestion and absorption_Homo sapiens_hsa049770.29030250
126Alcoholism_Homo sapiens_hsa050340.28610856
127Gastric acid secretion_Homo sapiens_hsa049710.28368530
128Malaria_Homo sapiens_hsa051440.27783203
129Mineral absorption_Homo sapiens_hsa049780.27503217
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25629933
131African trypanosomiasis_Homo sapiens_hsa051430.25329984
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.24849917
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.23546710
134Propanoate metabolism_Homo sapiens_hsa006400.21923346
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20333652
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20210635
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20037689
138cAMP signaling pathway_Homo sapiens_hsa040240.17904112

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