

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.89042351 |
| 2 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.89042351 |
| 3 | positive regulation of gamma-delta T cell activation (GO:0046645) | 6.53501904 |
| 4 | antigen processing and presentation of endogenous antigen (GO:0019883) | 6.25126837 |
| 5 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.96799818 |
| 6 | positive regulation by symbiont of host defense response (GO:0052509) | 5.60772691 |
| 7 | modulation by symbiont of host defense response (GO:0052031) | 5.60772691 |
| 8 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 5.60772691 |
| 9 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 5.60772691 |
| 10 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 5.60772691 |
| 11 | modulation by symbiont of host immune response (GO:0052553) | 5.60772691 |
| 12 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.56711645 |
| 13 | negative regulation of cell killing (GO:0031342) | 5.56711645 |
| 14 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.24617160 |
| 15 | leukocyte aggregation (GO:0070486) | 5.14087321 |
| 16 | interferon-gamma production (GO:0032609) | 5.10002084 |
| 17 | regulation of gamma-delta T cell differentiation (GO:0045586) | 5.06804183 |
| 18 | negative T cell selection (GO:0043383) | 4.98527155 |
| 19 | detection of other organism (GO:0098543) | 4.79645464 |
| 20 | negative thymic T cell selection (GO:0045060) | 4.76348863 |
| 21 | response to interleukin-15 (GO:0070672) | 4.71262916 |
| 22 | positive thymic T cell selection (GO:0045059) | 4.67009520 |
| 23 | regulation of gamma-delta T cell activation (GO:0046643) | 4.65192535 |
| 24 | negative regulation of phagocytosis (GO:0050765) | 4.60952647 |
| 25 | detection of bacterium (GO:0016045) | 4.59292245 |
| 26 | cellular response to interleukin-15 (GO:0071350) | 4.45075960 |
| 27 | macrophage activation involved in immune response (GO:0002281) | 4.44711837 |
| 28 | regulation of B cell differentiation (GO:0045577) | 4.42374194 |
| 29 | B cell receptor signaling pathway (GO:0050853) | 4.41945063 |
| 30 | positive T cell selection (GO:0043368) | 4.29783274 |
| 31 | response to peptidoglycan (GO:0032494) | 4.23910491 |
| 32 | detection of external biotic stimulus (GO:0098581) | 4.15011508 |
| 33 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 4.12475300 |
| 34 | response to host immune response (GO:0052572) | 4.12475300 |
| 35 | negative regulation of interleukin-12 production (GO:0032695) | 4.06241360 |
| 36 | T cell migration (GO:0072678) | 4.04966948 |
| 37 | thymic T cell selection (GO:0045061) | 4.04707817 |
| 38 | detection of molecule of bacterial origin (GO:0032490) | 4.04246120 |
| 39 | regulation of interferon-beta biosynthetic process (GO:0045357) | 4.00894976 |
| 40 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.99392096 |
| 41 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.99172629 |
| 42 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.98546250 |
| 43 | microglial cell activation (GO:0001774) | 3.97851528 |
| 44 | mast cell activation (GO:0045576) | 3.90758044 |
| 45 | positive regulation of B cell differentiation (GO:0045579) | 3.90464831 |
| 46 | T cell selection (GO:0045058) | 3.88912030 |
| 47 | cellular response to zinc ion (GO:0071294) | 3.77448024 |
| 48 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.77228905 |
| 49 | response to host (GO:0075136) | 3.76755081 |
| 50 | response to host defenses (GO:0052200) | 3.76755081 |
| 51 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.76755081 |
| 52 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.74399433 |
| 53 | cellular extravasation (GO:0045123) | 3.74188208 |
| 54 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.70710295 |
| 55 | leukocyte migration involved in inflammatory response (GO:0002523) | 3.69190713 |
| 56 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.68483196 |
| 57 | detection of biotic stimulus (GO:0009595) | 3.63505242 |
| 58 | ribosomal small subunit assembly (GO:0000028) | 3.62774808 |
| 59 | myeloid cell activation involved in immune response (GO:0002275) | 3.61625608 |
| 60 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.58609909 |
| 61 | T cell receptor signaling pathway (GO:0050852) | 3.54547191 |
| 62 | T cell homeostasis (GO:0043029) | 3.52060303 |
| 63 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.49106224 |
| 64 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.49106224 |
| 65 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.48699544 |
| 66 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.48644560 |
| 67 | granulocyte activation (GO:0036230) | 3.46788455 |
| 68 | B cell mediated immunity (GO:0019724) | 3.45761546 |
| 69 | T cell costimulation (GO:0031295) | 3.42103147 |
| 70 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.41270930 |
| 71 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.40210958 |
| 72 | regulation of mast cell degranulation (GO:0043304) | 3.38543444 |
| 73 | macrophage activation (GO:0042116) | 3.38169686 |
| 74 | lymphocyte costimulation (GO:0031294) | 3.35016497 |
| 75 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.34040345 |
| 76 | regulation of tolerance induction (GO:0002643) | 3.29101080 |
| 77 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.26525442 |
| 78 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.24394840 |
| 79 | regulation of regulatory T cell differentiation (GO:0045589) | 3.23335790 |
| 80 | mast cell activation involved in immune response (GO:0002279) | 3.21331602 |
| 81 | mast cell degranulation (GO:0043303) | 3.21331602 |
| 82 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.20895384 |
| 83 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.20895384 |
| 84 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.20279625 |
| 85 | tolerance induction (GO:0002507) | 3.20276729 |
| 86 | negative regulation of innate immune response (GO:0045824) | 3.19980686 |
| 87 | leukocyte cell-cell adhesion (GO:0007159) | 3.18292978 |
| 88 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.16460422 |
| 89 | respiratory burst (GO:0045730) | 3.16292456 |
| 90 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.14914055 |
| 91 | activated T cell proliferation (GO:0050798) | 3.13784456 |
| 92 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.13200427 |
| 93 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.13055976 |
| 94 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.13051049 |
| 95 | regulation of response to interferon-gamma (GO:0060330) | 3.12362034 |
| 96 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.12018535 |
| 97 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.09832161 |
| 98 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.09790180 |
| 99 | regulation of mast cell activation (GO:0033003) | 3.09006959 |
| 100 | positive regulation of interferon-alpha production (GO:0032727) | 3.08989336 |
| 101 | dendritic cell chemotaxis (GO:0002407) | 3.08746229 |
| 102 | dendritic cell migration (GO:0036336) | 3.06419997 |
| 103 | lymphocyte homeostasis (GO:0002260) | 3.06039812 |
| 104 | response to muramyl dipeptide (GO:0032495) | 3.05418188 |
| 105 | angiogenesis involved in wound healing (GO:0060055) | 3.04923154 |
| 106 | antigen processing and presentation via MHC class Ib (GO:0002475) | 2.99330701 |
| 107 | negative regulation of T cell mediated immunity (GO:0002710) | 2.95214792 |
| 108 | natural killer cell activation (GO:0030101) | 2.93790239 |
| 109 | neutrophil mediated immunity (GO:0002446) | 2.93346283 |
| 110 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.92984090 |
| 111 | positive regulation of lamellipodium assembly (GO:0010592) | 2.92402115 |
| 112 | positive regulation of isotype switching (GO:0045830) | 2.91716966 |
| 113 | positive regulation of interleukin-2 production (GO:0032743) | 2.89566964 |
| 114 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 2.89284451 |
| 115 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.88258424 |
| 116 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 2.87738053 |
| 117 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.86519261 |
| 118 | megakaryocyte development (GO:0035855) | 2.85583714 |
| 119 | neutrophil activation (GO:0042119) | 2.82537832 |
| 120 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.81704389 |
| 121 | viral transcription (GO:0019083) | 2.80342745 |
| 122 | T cell proliferation (GO:0042098) | 2.79489763 |
| 123 | cellular response to interferon-beta (GO:0035458) | 2.79060303 |
| 124 | response to type I interferon (GO:0034340) | 2.78884656 |
| 125 | response to protozoan (GO:0001562) | 2.78255253 |
| 126 | immunoglobulin mediated immune response (GO:0016064) | 2.77452249 |
| 127 | regulation of T cell tolerance induction (GO:0002664) | 2.76178012 |
| 128 | leukocyte homeostasis (GO:0001776) | 2.75580877 |
| 129 | defense response to fungus (GO:0050832) | 2.74957073 |
| 130 | neutrophil activation involved in immune response (GO:0002283) | 2.74391777 |
| 131 | positive regulation of granulocyte differentiation (GO:0030854) | 2.73799393 |
| 132 | type I interferon signaling pathway (GO:0060337) | 2.72067892 |
| 133 | cellular response to type I interferon (GO:0071357) | 2.72067892 |
| 134 | V(D)J recombination (GO:0033151) | 2.71880939 |
| 135 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.71219629 |
| 136 | hepatocyte apoptotic process (GO:0097284) | 2.68586694 |
| 137 | defense response to protozoan (GO:0042832) | 2.67192821 |
| 138 | NIK/NF-kappaB signaling (GO:0038061) | 2.65159587 |
| 139 | myeloid dendritic cell activation (GO:0001773) | 2.63872163 |
| 140 | T cell differentiation (GO:0030217) | 2.63440160 |
| 141 | translational termination (GO:0006415) | 2.63164764 |
| 142 | alpha-beta T cell activation (GO:0046631) | 2.60674560 |
| 143 | positive regulation of mast cell activation (GO:0033005) | 2.59830447 |
| 144 | leukocyte degranulation (GO:0043299) | 2.59280160 |
| 145 | T cell activation (GO:0042110) | 2.58942708 |
| 146 | cellular defense response (GO:0006968) | 2.58618251 |
| 147 | B cell proliferation (GO:0042100) | 2.57467528 |
| 148 | lymphocyte proliferation (GO:0046651) | 2.56482671 |
| 149 | mature B cell differentiation (GO:0002335) | 2.56270635 |
| 150 | mononuclear cell proliferation (GO:0032943) | 2.55744113 |
| 151 | regulation of B cell mediated immunity (GO:0002712) | 2.53859657 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.08486380 |
| 2 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.81500098 |
| 3 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 4.32081053 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.98031207 |
| 5 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.43683023 |
| 6 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.41246861 |
| 7 | MYC_22102868_ChIP-Seq_BL_Human | 3.33820781 |
| 8 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.01389855 |
| 9 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.91935123 |
| 10 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.84978855 |
| 11 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.80180052 |
| 12 | * MYB_26560356_Chip-Seq_TH2_Human | 2.75113537 |
| 13 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.72929113 |
| 14 | * MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.68941432 |
| 15 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.66469514 |
| 16 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.64841808 |
| 17 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.56046409 |
| 18 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.52259690 |
| 19 | * MAF_26560356_Chip-Seq_TH1_Human | 2.47652254 |
| 20 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.45886324 |
| 21 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.43819991 |
| 22 | * RUNX_20019798_ChIP-Seq_JUKART_Human | 2.42457287 |
| 23 | * MYB_26560356_Chip-Seq_TH1_Human | 2.35453113 |
| 24 | UTX_26944678_Chip-Seq_JUKART_Human | 2.34856380 |
| 25 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.33361869 |
| 26 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.32214485 |
| 27 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.30132066 |
| 28 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.23379692 |
| 29 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.22773827 |
| 30 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.12900460 |
| 31 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.08752378 |
| 32 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.07126383 |
| 33 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.06733958 |
| 34 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.03724668 |
| 35 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 2.03609021 |
| 36 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.03419227 |
| 37 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.02545828 |
| 38 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.90310797 |
| 39 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.84839977 |
| 40 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.81721102 |
| 41 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.79801999 |
| 42 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.77831555 |
| 43 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.77594301 |
| 44 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.77535736 |
| 45 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.75421822 |
| 46 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.71342048 |
| 47 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.67632425 |
| 48 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.64742620 |
| 49 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.63111108 |
| 50 | * MAF_26560356_Chip-Seq_TH2_Human | 1.63029371 |
| 51 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 1.62356201 |
| 52 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.61037526 |
| 53 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.49614787 |
| 54 | SPI1_23127762_ChIP-Seq_K562_Human | 1.49319097 |
| 55 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.47653872 |
| 56 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.44835569 |
| 57 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.44400662 |
| 58 | * Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.44123585 |
| 59 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.43654539 |
| 60 | GATA1_22025678_ChIP-Seq_K562_Human | 1.43624463 |
| 61 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.41482190 |
| 62 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.39742311 |
| 63 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.37539117 |
| 64 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.36860749 |
| 65 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.34991515 |
| 66 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.28668466 |
| 67 | * PU_27001747_Chip-Seq_BMDM_Mouse | 1.28060607 |
| 68 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.24475484 |
| 69 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.24350463 |
| 70 | * PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.23736306 |
| 71 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.21524948 |
| 72 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.20998703 |
| 73 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.17811698 |
| 74 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.16982625 |
| 75 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.16114384 |
| 76 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14663445 |
| 77 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.13986259 |
| 78 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.12608847 |
| 79 | GATA3_26560356_Chip-Seq_TH2_Human | 1.12377533 |
| 80 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.11518913 |
| 81 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.10939118 |
| 82 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.10069448 |
| 83 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.07474719 |
| 84 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.04903298 |
| 85 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.04204147 |
| 86 | * CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.04135390 |
| 87 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02137968 |
| 88 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.02065393 |
| 89 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.01996132 |
| 90 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.00526799 |
| 91 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.98881573 |
| 92 | GATA1_19941826_ChIP-Seq_K562_Human | 0.98698195 |
| 93 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.98240336 |
| 94 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.97968126 |
| 95 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.97914234 |
| 96 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.97772229 |
| 97 | * CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.96914744 |
| 98 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.93954198 |
| 99 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.93440837 |
| 100 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.92922231 |
| 101 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.92713233 |
| 102 | * PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.91476462 |
| 103 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.91293186 |
| 104 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.91250339 |
| 105 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.91059760 |
| 106 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.91048503 |
| 107 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.88098782 |
| 108 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87776119 |
| 109 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.87619895 |
| 110 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.87266594 |
| 111 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.86347123 |
| 112 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.86006709 |
| 113 | * CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.85755084 |
| 114 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.85565950 |
| 115 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.85366995 |
| 116 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83995617 |
| 117 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.83304532 |
| 118 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.82279348 |
| 119 | P300_27268052_Chip-Seq_Bcells_Human | 0.82117147 |
| 120 | * CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.81662681 |
| 121 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.78729253 |
| 122 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.77030278 |
| 123 | GATA2_19941826_ChIP-Seq_K562_Human | 0.76742893 |
| 124 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.75937814 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.03596651 |
| 2 | MP0003763_abnormal_thymus_physiology | 3.97429726 |
| 3 | MP0002396_abnormal_hematopoietic_system | 3.57709432 |
| 4 | MP0005671_abnormal_response_to | 3.38709303 |
| 5 | MP0001800_abnormal_humoral_immune | 3.27931033 |
| 6 | MP0000685_abnormal_immune_system | 3.13948620 |
| 7 | MP0001790_abnormal_immune_system | 2.88614520 |
| 8 | MP0005387_immune_system_phenotype | 2.88614520 |
| 9 | * MP0002420_abnormal_adaptive_immunity | 2.87175922 |
| 10 | MP0003436_decreased_susceptibility_to | 2.85466715 |
| 11 | MP0009785_altered_susceptibility_to | 2.85104086 |
| 12 | * MP0001819_abnormal_immune_cell | 2.82554873 |
| 13 | * MP0002398_abnormal_bone_marrow | 2.82389679 |
| 14 | * MP0002452_abnormal_antigen_presenting | 2.76706110 |
| 15 | MP0002723_abnormal_immune_serum | 2.72571570 |
| 16 | MP0002166_altered_tumor_susceptibility | 2.71155355 |
| 17 | * MP0005000_abnormal_immune_tolerance | 2.70877497 |
| 18 | MP0005025_abnormal_response_to | 2.65795138 |
| 19 | MP0003303_peritoneal_inflammation | 2.61469487 |
| 20 | * MP0000716_abnormal_immune_system | 2.48302922 |
| 21 | * MP0002419_abnormal_innate_immunity | 2.41233386 |
| 22 | * MP0000689_abnormal_spleen_morphology | 2.28395534 |
| 23 | MP0000703_abnormal_thymus_morphology | 2.25675749 |
| 24 | * MP0002722_abnormal_immune_system | 2.23587451 |
| 25 | MP0009333_abnormal_splenocyte_physiolog | 2.21934816 |
| 26 | MP0002006_tumorigenesis | 2.20862783 |
| 27 | MP0002405_respiratory_system_inflammati | 2.18891435 |
| 28 | MP0001873_stomach_inflammation | 2.15747774 |
| 29 | MP0004808_abnormal_hematopoietic_stem | 2.13098966 |
| 30 | MP0001853_heart_inflammation | 2.11412622 |
| 31 | * MP0002429_abnormal_blood_cell | 2.10112606 |
| 32 | * MP0002148_abnormal_hypersensitivity_rea | 2.05665623 |
| 33 | MP0005464_abnormal_platelet_physiology | 2.04247338 |
| 34 | MP0003300_gastrointestinal_ulcer | 1.99883063 |
| 35 | MP0010155_abnormal_intestine_physiology | 1.93296424 |
| 36 | MP0003724_increased_susceptibility_to | 1.85770005 |
| 37 | MP0009278_abnormal_bone_marrow | 1.84697748 |
| 38 | MP0001545_abnormal_hematopoietic_system | 1.83085970 |
| 39 | MP0005397_hematopoietic_system_phenotyp | 1.83085970 |
| 40 | MP0000465_gastrointestinal_hemorrhage | 1.81188593 |
| 41 | MP0003866_abnormal_defecation | 1.73360647 |
| 42 | * MP0001845_abnormal_inflammatory_respons | 1.72487129 |
| 43 | MP0008260_abnormal_autophagy | 1.64826464 |
| 44 | MP0008057_abnormal_DNA_replication | 1.60749479 |
| 45 | MP0005174_abnormal_tail_pigmentation | 1.54981682 |
| 46 | MP0002277_abnormal_respiratory_mucosa | 1.52268235 |
| 47 | MP0010094_abnormal_chromosome_stability | 1.49976313 |
| 48 | MP0004947_skin_inflammation | 1.49346992 |
| 49 | MP0005075_abnormal_melanosome_morpholog | 1.46536858 |
| 50 | MP0000490_abnormal_crypts_of | 1.43680210 |
| 51 | * MP0000858_altered_metastatic_potential | 1.35671791 |
| 52 | MP0002933_joint_inflammation | 1.34653666 |
| 53 | MP0003077_abnormal_cell_cycle | 1.34101120 |
| 54 | MP0003693_abnormal_embryo_hatching | 1.33555801 |
| 55 | MP0006082_CNS_inflammation | 1.27372643 |
| 56 | MP0004883_abnormal_blood_vessel | 1.26716564 |
| 57 | * MP0002019_abnormal_tumor_incidence | 1.25394682 |
| 58 | MP0003183_abnormal_peptide_metabolism | 1.21775886 |
| 59 | MP0005451_abnormal_body_composition | 1.19032461 |
| 60 | MP0001533_abnormal_skeleton_physiology | 1.15341930 |
| 61 | * MP0008469_abnormal_protein_level | 1.13279594 |
| 62 | MP0003111_abnormal_nucleus_morphology | 1.12534184 |
| 63 | MP0002009_preneoplasia | 1.10447225 |
| 64 | MP0003075_altered_response_to | 1.08985137 |
| 65 | MP0004381_abnormal_hair_follicle | 1.06948908 |
| 66 | MP0002095_abnormal_skin_pigmentation | 1.02192253 |
| 67 | MP0004957_abnormal_blastocyst_morpholog | 1.01524036 |
| 68 | MP0003806_abnormal_nucleotide_metabolis | 1.01246488 |
| 69 | MP0010352_gastrointestinal_tract_polyps | 0.99108428 |
| 70 | MP0000015_abnormal_ear_pigmentation | 0.97514537 |
| 71 | MP0005164_abnormal_response_to | 0.95691739 |
| 72 | MP0005310_abnormal_salivary_gland | 0.94474465 |
| 73 | MP0006054_spinal_hemorrhage | 0.92837908 |
| 74 | * MP0003448_altered_tumor_morphology | 0.92804157 |
| 75 | MP0005166_decreased_susceptibility_to | 0.92133585 |
| 76 | MP0009764_decreased_sensitivity_to | 0.91501493 |
| 77 | MP0010307_abnormal_tumor_latency | 0.88085165 |
| 78 | MP0003690_abnormal_glial_cell | 0.85695984 |
| 79 | MP0008058_abnormal_DNA_repair | 0.85152490 |
| 80 | MP0003045_fibrosis | 0.84766087 |
| 81 | MP0005390_skeleton_phenotype | 0.82114265 |
| 82 | MP0004510_myositis | 0.82039274 |
| 83 | MP0000343_altered_response_to | 0.80028656 |
| 84 | MP0003172_abnormal_lysosome_physiology | 0.79110084 |
| 85 | MP0005023_abnormal_wound_healing | 0.77723549 |
| 86 | MP0008007_abnormal_cellular_replicative | 0.77437314 |
| 87 | MP0001851_eye_inflammation | 0.75133973 |
| 88 | MP0009763_increased_sensitivity_to | 0.70970047 |
| 89 | MP0001663_abnormal_digestive_system | 0.70473635 |
| 90 | MP0002132_abnormal_respiratory_system | 0.69315426 |
| 91 | MP0000313_abnormal_cell_death | 0.68683470 |
| 92 | MP0000350_abnormal_cell_proliferation | 0.65499417 |
| 93 | MP0005076_abnormal_cell_differentiation | 0.63971751 |
| 94 | MP0004130_abnormal_muscle_cell | 0.62901680 |
| 95 | MP0009765_abnormal_xenobiotic_induced | 0.62367950 |
| 96 | MP0003252_abnormal_bile_duct | 0.61416170 |
| 97 | MP0003828_pulmonary_edema | 0.61267941 |
| 98 | MP0000371_diluted_coat_color | 0.61082153 |
| 99 | MP0002138_abnormal_hepatobiliary_system | 0.61023112 |
| 100 | MP0005084_abnormal_gallbladder_morpholo | 0.58793882 |
| 101 | MP0000604_amyloidosis | 0.58106293 |
| 102 | MP0003279_aneurysm | 0.56327510 |
| 103 | MP0000569_abnormal_digit_pigmentation | 0.56282111 |
| 104 | MP0005319_abnormal_enzyme/_coenzyme | 0.55954489 |
| 105 | MP0008004_abnormal_stomach_pH | 0.55768933 |
| 106 | MP0008873_increased_physiological_sensi | 0.55744280 |
| 107 | MP0003191_abnormal_cellular_cholesterol | 0.55545162 |
| 108 | MP0008874_decreased_physiological_sensi | 0.55301075 |
| 109 | MP0000249_abnormal_blood_vessel | 0.53104849 |
| 110 | MP0000477_abnormal_intestine_morphology | 0.52576334 |
| 111 | MP0004484_altered_response_of | 0.51636798 |
| 112 | MP0003656_abnormal_erythrocyte_physiolo | 0.51372084 |
| 113 | MP0008961_abnormal_basal_metabolism | 0.50868275 |
| 114 | MP0001986_abnormal_taste_sensitivity | 0.50536941 |
| 115 | MP0003787_abnormal_imprinting | 0.50328823 |
| 116 | MP0002998_abnormal_bone_remodeling | 0.50308748 |
| 117 | * MP0002693_abnormal_pancreas_physiology | 0.47947342 |
| 118 | MP0005058_abnormal_lysosome_morphology | 0.47787427 |
| 119 | MP0003795_abnormal_bone_structure | 0.47285839 |
| 120 | MP0002928_abnormal_bile_duct | 0.47127215 |
| 121 | MP0005376_homeostasis/metabolism_phenot | 0.46768772 |
| 122 | MP0001730_embryonic_growth_arrest | 0.43187523 |
| 123 | MP0000609_abnormal_liver_physiology | 0.42291182 |
| 124 | MP0005621_abnormal_cell_physiology | 0.42098294 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 5.22716963 |
| 2 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.04801042 |
| 3 | Abnormality of T cell number (HP:0011839) | 4.95416313 |
| 4 | Chronic otitis media (HP:0000389) | 4.95217990 |
| 5 | Recurrent viral infections (HP:0004429) | 4.75175097 |
| 6 | IgM deficiency (HP:0002850) | 4.71023374 |
| 7 | Recurrent bronchitis (HP:0002837) | 4.62798626 |
| 8 | Recurrent abscess formation (HP:0002722) | 4.52480504 |
| 9 | Gastrointestinal infarctions (HP:0005244) | 4.40368575 |
| 10 | Recurrent fungal infections (HP:0002841) | 4.39615247 |
| 11 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.31984689 |
| 12 | Abnormality of T cells (HP:0002843) | 4.24572513 |
| 13 | Eczematoid dermatitis (HP:0000976) | 4.00363547 |
| 14 | Agammaglobulinemia (HP:0004432) | 3.98546770 |
| 15 | Panhypogammaglobulinemia (HP:0003139) | 3.96505785 |
| 16 | Keratoconjunctivitis (HP:0001096) | 3.94617530 |
| 17 | Recurrent bacterial skin infections (HP:0005406) | 3.91633458 |
| 18 | Myositis (HP:0100614) | 3.90600712 |
| 19 | Meningitis (HP:0001287) | 3.87678297 |
| 20 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.77769000 |
| 21 | Recurrent cutaneous fungal infections (HP:0011370) | 3.77769000 |
| 22 | Hypochromic microcytic anemia (HP:0004840) | 3.77159494 |
| 23 | Nasal polyposis (HP:0100582) | 3.72575944 |
| 24 | Thrombocytosis (HP:0001894) | 3.67140028 |
| 25 | Spontaneous hematomas (HP:0007420) | 3.58587751 |
| 26 | Mediastinal lymphadenopathy (HP:0100721) | 3.57464637 |
| 27 | Stomatitis (HP:0010280) | 3.40594876 |
| 28 | Cellulitis (HP:0100658) | 3.32169431 |
| 29 | Abnormality of T cell physiology (HP:0011840) | 3.31621252 |
| 30 | Inflammation of the large intestine (HP:0002037) | 3.31536908 |
| 31 | Obstructive lung disease (HP:0006536) | 3.31100981 |
| 32 | Chronic obstructive pulmonary disease (HP:0006510) | 3.31100981 |
| 33 | Gastrointestinal inflammation (HP:0004386) | 3.31004643 |
| 34 | Hypochromic anemia (HP:0001931) | 3.29781354 |
| 35 | Lymphopenia (HP:0001888) | 3.28819064 |
| 36 | Recurrent skin infections (HP:0001581) | 3.27517472 |
| 37 | Abnormality of the fingertips (HP:0001211) | 3.24812969 |
| 38 | Arterial thrombosis (HP:0004420) | 3.22670543 |
| 39 | Thyroiditis (HP:0100646) | 3.18260480 |
| 40 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.17722426 |
| 41 | B lymphocytopenia (HP:0010976) | 3.15558595 |
| 42 | Abnormality of B cell number (HP:0010975) | 3.15558595 |
| 43 | Abnormality of the nasal mucosa (HP:0000433) | 3.15029617 |
| 44 | Combined immunodeficiency (HP:0005387) | 3.12142348 |
| 45 | IgG deficiency (HP:0004315) | 3.11675877 |
| 46 | Eosinophilia (HP:0001880) | 3.11530497 |
| 47 | Severe combined immunodeficiency (HP:0004430) | 3.10208595 |
| 48 | Pustule (HP:0200039) | 3.08358100 |
| 49 | Papilloma (HP:0012740) | 3.04850871 |
| 50 | Verrucae (HP:0200043) | 3.04850871 |
| 51 | Recurrent sinusitis (HP:0011108) | 2.96878069 |
| 52 | Increased IgM level (HP:0003496) | 2.95352415 |
| 53 | Anorexia (HP:0002039) | 2.95327477 |
| 54 | Granulocytopenia (HP:0001913) | 2.90634403 |
| 55 | Abnormality of eosinophils (HP:0001879) | 2.89483554 |
| 56 | Colitis (HP:0002583) | 2.87825430 |
| 57 | Pulmonary embolism (HP:0002204) | 2.87587516 |
| 58 | Episodic fever (HP:0001954) | 2.86768591 |
| 59 | Papilledema (HP:0001085) | 2.85961413 |
| 60 | Encephalitis (HP:0002383) | 2.84711498 |
| 61 | Vasculitis (HP:0002633) | 2.81569135 |
| 62 | Chronic sinusitis (HP:0011109) | 2.75724701 |
| 63 | Leukocytosis (HP:0001974) | 2.73959806 |
| 64 | Peritonitis (HP:0002586) | 2.73783658 |
| 65 | Lymphoma (HP:0002665) | 2.72069983 |
| 66 | Petechiae (HP:0000967) | 2.69751325 |
| 67 | Chronic diarrhea (HP:0002028) | 2.68311730 |
| 68 | Reticulocytopenia (HP:0001896) | 2.68110436 |
| 69 | Abnormality of the pleura (HP:0002103) | 2.66277737 |
| 70 | Bronchitis (HP:0012387) | 2.62150375 |
| 71 | Gangrene (HP:0100758) | 2.60164598 |
| 72 | Increased IgE level (HP:0003212) | 2.54230318 |
| 73 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.53232865 |
| 74 | Prolonged bleeding time (HP:0003010) | 2.51883834 |
| 75 | Microcytic anemia (HP:0001935) | 2.51879251 |
| 76 | Hypoplasia of the thymus (HP:0000778) | 2.41056487 |
| 77 | Epistaxis (HP:0000421) | 2.39616949 |
| 78 | Autoimmune thrombocytopenia (HP:0001973) | 2.39600915 |
| 79 | Abnormality of macrophages (HP:0004311) | 2.38062998 |
| 80 | Abnormal platelet volume (HP:0011876) | 2.37808788 |
| 81 | Acute hepatic failure (HP:0006554) | 2.37444217 |
| 82 | Chest pain (HP:0100749) | 2.35038192 |
| 83 | Abnormality of the peritoneum (HP:0002585) | 2.33935624 |
| 84 | Gastrointestinal stroma tumor (HP:0100723) | 2.33493973 |
| 85 | Basal cell carcinoma (HP:0002671) | 2.32515468 |
| 86 | Periodontitis (HP:0000704) | 2.31569152 |
| 87 | Glomerulopathy (HP:0100820) | 2.27632954 |
| 88 | Keratitis (HP:0000491) | 2.26699742 |
| 89 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.25955832 |
| 90 | Interstitial pulmonary disease (HP:0006530) | 2.25748605 |
| 91 | Hemoptysis (HP:0002105) | 2.25398461 |
| 92 | Skin ulcer (HP:0200042) | 2.23709043 |
| 93 | IgA deficiency (HP:0002720) | 2.23410099 |
| 94 | Vertigo (HP:0002321) | 2.23337975 |
| 95 | Sepsis (HP:0100806) | 2.19391317 |
| 96 | Gingivitis (HP:0000230) | 2.16551519 |
| 97 | Amyloidosis (HP:0011034) | 2.16113462 |
| 98 | Pulmonary infiltrates (HP:0002113) | 2.14809428 |
| 99 | Orchitis (HP:0100796) | 2.12269198 |
| 100 | Osteomyelitis (HP:0002754) | 2.11599556 |
| 101 | Abnormality of the endocardium (HP:0004306) | 2.10559319 |
| 102 | Hypergammaglobulinemia (HP:0010702) | 2.10350232 |
| 103 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.09250900 |
| 104 | Poikiloderma (HP:0001029) | 2.08255244 |
| 105 | Acne (HP:0001061) | 2.08240511 |
| 106 | Abnormal number of erythroid precursors (HP:0012131) | 2.05870973 |
| 107 | Stomach cancer (HP:0012126) | 2.05870075 |
| 108 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.05568001 |
| 109 | Abnormality of the pericardium (HP:0001697) | 2.05166649 |
| 110 | Abnormality of the prostate (HP:0008775) | 2.04426299 |
| 111 | Optic neuritis (HP:0100653) | 2.02779281 |
| 112 | Retrobulbar optic neuritis (HP:0100654) | 2.02779281 |
| 113 | Impaired platelet aggregation (HP:0003540) | 2.01699599 |
| 114 | Abnormal platelet function (HP:0011869) | 2.01699599 |
| 115 | Joint swelling (HP:0001386) | 1.98800262 |
| 116 | Polyneuropathy (HP:0001271) | 1.98289193 |
| 117 | Keratoconjunctivitis sicca (HP:0001097) | 1.97958619 |
| 118 | Thrombophlebitis (HP:0004418) | 1.97774306 |
| 119 | Recurrent otitis media (HP:0000403) | 1.96482927 |
| 120 | Emphysema (HP:0002097) | 1.95712446 |
| 121 | Amaurosis fugax (HP:0100576) | 1.95229216 |
| 122 | Abnormality of DNA repair (HP:0003254) | 1.93725478 |
| 123 | Autoimmune hemolytic anemia (HP:0001890) | 1.93682183 |
| 124 | Gingival bleeding (HP:0000225) | 1.92983124 |
| 125 | Viral hepatitis (HP:0006562) | 1.92933079 |
| 126 | Skin rash (HP:0000988) | 1.91439845 |
| 127 | Neutropenia (HP:0001875) | 1.90248370 |
| 128 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.88812413 |
| 129 | Urticaria (HP:0001025) | 1.86207329 |
| 130 | Cheilitis (HP:0100825) | 1.85998115 |
| 131 | Recurrent pneumonia (HP:0006532) | 1.84292125 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 5.33525095 |
| 2 | TXK | 3.53352199 |
| 3 | STK10 | 3.00658515 |
| 4 | GRK6 | 2.86100151 |
| 5 | ITK | 2.61957823 |
| 6 | TEC | 2.58291646 |
| 7 | BTK | 2.49224853 |
| 8 | IRAK4 | 2.46401063 |
| 9 | TYK2 | 2.42361689 |
| 10 | JAK3 | 2.36780168 |
| 11 | BLK | 2.33015912 |
| 12 | EEF2K | 2.26381449 |
| 13 | ZAP70 | 2.25406085 |
| 14 | KIT | 2.02423853 |
| 15 | CLK1 | 1.82365099 |
| 16 | LRRK2 | 1.73005028 |
| 17 | IKBKE | 1.72206555 |
| 18 | SYK | 1.71947855 |
| 19 | NLK | 1.70561219 |
| 20 | CSK | 1.67860162 |
| 21 | FLT3 | 1.66129787 |
| 22 | FGFR4 | 1.62075894 |
| 23 | MAP3K10 | 1.60496056 |
| 24 | MAP3K14 | 1.59900598 |
| 25 | PRPF4B | 1.54697882 |
| 26 | MAP3K13 | 1.53775176 |
| 27 | MAP3K11 | 1.53762320 |
| 28 | LCK | 1.47577573 |
| 29 | JAK1 | 1.46391623 |
| 30 | FES | 1.45340208 |
| 31 | HCK | 1.42899132 |
| 32 | CSF1R | 1.42191237 |
| 33 | PKN2 | 1.41728788 |
| 34 | FGR | 1.36070594 |
| 35 | MAP3K3 | 1.34401898 |
| 36 | MARK3 | 1.30921062 |
| 37 | FGFR3 | 1.30492649 |
| 38 | MAP2K3 | 1.27149569 |
| 39 | TBK1 | 1.25348376 |
| 40 | BMPR2 | 1.24724510 |
| 41 | PIM1 | 1.22361784 |
| 42 | MST4 | 1.20003377 |
| 43 | TESK2 | 1.19794453 |
| 44 | CDK19 | 1.11548452 |
| 45 | MAP3K1 | 1.08676869 |
| 46 | BRSK2 | 1.05675647 |
| 47 | RPS6KA4 | 1.03038512 |
| 48 | LYN | 1.02340931 |
| 49 | TNK2 | 1.01010457 |
| 50 | TAOK3 | 1.00942315 |
| 51 | RIPK4 | 1.00499545 |
| 52 | EPHB1 | 0.95368424 |
| 53 | ERN1 | 0.94562969 |
| 54 | TRPM7 | 0.93847247 |
| 55 | MATK | 0.89195423 |
| 56 | NME2 | 0.88215917 |
| 57 | IRAK1 | 0.87731923 |
| 58 | CDC7 | 0.87451045 |
| 59 | STK4 | 0.87031906 |
| 60 | YES1 | 0.86593250 |
| 61 | PIK3CG | 0.83601679 |
| 62 | PRKCQ | 0.83380810 |
| 63 | RPS6KB2 | 0.83358923 |
| 64 | KSR2 | 0.81178059 |
| 65 | IKBKB | 0.80179644 |
| 66 | CDK4 | 0.77828117 |
| 67 | TGFBR2 | 0.76375476 |
| 68 | EIF2AK3 | 0.76223591 |
| 69 | MAP2K6 | 0.75209364 |
| 70 | MAP3K6 | 0.75113256 |
| 71 | NEK2 | 0.73912432 |
| 72 | JAK2 | 0.68842653 |
| 73 | PTK6 | 0.67867628 |
| 74 | MAP3K12 | 0.66925294 |
| 75 | SIK2 | 0.66413605 |
| 76 | SCYL2 | 0.64581353 |
| 77 | MARK2 | 0.64513653 |
| 78 | ATR | 0.64463450 |
| 79 | MAP3K8 | 0.62783476 |
| 80 | CDK12 | 0.62400860 |
| 81 | PTK2B | 0.60208680 |
| 82 | TAOK2 | 0.59692608 |
| 83 | HIPK2 | 0.59677065 |
| 84 | MAP3K5 | 0.58795519 |
| 85 | KDR | 0.58266992 |
| 86 | ACVR1B | 0.58019439 |
| 87 | MAPK4 | 0.56473227 |
| 88 | PASK | 0.55126668 |
| 89 | RPS6KA6 | 0.53975448 |
| 90 | EPHA3 | 0.53308888 |
| 91 | IRAK3 | 0.52676096 |
| 92 | STK11 | 0.51429581 |
| 93 | IRAK2 | 0.50777618 |
| 94 | TGFBR1 | 0.50400719 |
| 95 | CAMKK1 | 0.50206153 |
| 96 | DYRK1B | 0.49211564 |
| 97 | PRKCH | 0.48423133 |
| 98 | PDPK1 | 0.48153239 |
| 99 | PDK1 | 0.46920354 |
| 100 | MAPK7 | 0.46795991 |
| 101 | MAPK11 | 0.46353996 |
| 102 | MAP2K4 | 0.46069747 |
| 103 | SIK3 | 0.43903694 |
| 104 | TRIB3 | 0.43889803 |
| 105 | ALK | 0.43620103 |
| 106 | GRK7 | 0.42999778 |
| 107 | MAP3K2 | 0.42994107 |
| 108 | TTN | 0.42687398 |
| 109 | MAP2K2 | 0.42345530 |
| 110 | PIM2 | 0.41768752 |
| 111 | RPS6KL1 | 0.41175177 |
| 112 | RPS6KC1 | 0.41175177 |
| 113 | CAMKK2 | 0.40888600 |
| 114 | TLK1 | 0.40521949 |
| 115 | SRPK1 | 0.39810124 |
| 116 | SMG1 | 0.34751164 |
| 117 | CHUK | 0.34673115 |
| 118 | CDK6 | 0.33211898 |
| 119 | DAPK2 | 0.32212489 |
| 120 | STK38 | 0.32018183 |
| 121 | MAP3K7 | 0.30518446 |
| 122 | PRKCD | 0.29956061 |
| 123 | RET | 0.29738245 |
| 124 | PRKD2 | 0.28986355 |
| 125 | MAPKAPK2 | 0.27991034 |
| 126 | BRSK1 | 0.27786728 |
| 127 | TAOK1 | 0.27669924 |
| 128 | BRD4 | 0.27533994 |
| 129 | EIF2AK1 | 0.27471759 |
| 130 | CDK9 | 0.27004927 |
| 131 | DYRK3 | 0.26710295 |
| 132 | RAF1 | 0.26676041 |
| 133 | MAPK12 | 0.26128013 |
| 134 | CDK7 | 0.26056912 |
| 135 | ABL1 | 0.25688778 |
| 136 | FYN | 0.25560016 |
| 137 | VRK1 | 0.25545422 |
| 138 | CDC42BPA | 0.24376454 |
| 139 | SGK3 | 0.24260268 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 4.59487151 |
| 2 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.79236951 |
| 3 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.62930969 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 2.56224733 |
| 5 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.48157970 |
| 6 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.44672950 |
| 7 | Leishmaniasis_Homo sapiens_hsa05140 | 2.37801866 |
| 8 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.33787628 |
| 9 | Measles_Homo sapiens_hsa05162 | 2.32440699 |
| 10 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.19854525 |
| 11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.08686207 |
| 12 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.99751150 |
| 13 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.92152233 |
| 14 | Ribosome_Homo sapiens_hsa03010 | 1.86259289 |
| 15 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.83989365 |
| 16 | Base excision repair_Homo sapiens_hsa03410 | 1.81871547 |
| 17 | Mismatch repair_Homo sapiens_hsa03430 | 1.76665184 |
| 18 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.75120449 |
| 19 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.73861900 |
| 20 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.68455942 |
| 21 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.65250377 |
| 22 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.63259282 |
| 23 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.57584260 |
| 24 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.53254597 |
| 25 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.52373266 |
| 26 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.48246048 |
| 27 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.43147157 |
| 28 | Hepatitis B_Homo sapiens_hsa05161 | 1.42355377 |
| 29 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.40116775 |
| 30 | Viral myocarditis_Homo sapiens_hsa05416 | 1.39325369 |
| 31 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.38259728 |
| 32 | Shigellosis_Homo sapiens_hsa05131 | 1.35322916 |
| 33 | Spliceosome_Homo sapiens_hsa03040 | 1.35212909 |
| 34 | Allograft rejection_Homo sapiens_hsa05330 | 1.33009194 |
| 35 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.23155555 |
| 36 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.22781492 |
| 37 | Homologous recombination_Homo sapiens_hsa03440 | 1.22597719 |
| 38 | Influenza A_Homo sapiens_hsa05164 | 1.21258763 |
| 39 | Phagosome_Homo sapiens_hsa04145 | 1.17834888 |
| 40 | Tuberculosis_Homo sapiens_hsa05152 | 1.15406990 |
| 41 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.14042653 |
| 42 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.10038972 |
| 43 | Apoptosis_Homo sapiens_hsa04210 | 1.10012069 |
| 44 | Platelet activation_Homo sapiens_hsa04611 | 1.08642007 |
| 45 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.06642984 |
| 46 | Legionellosis_Homo sapiens_hsa05134 | 1.04822124 |
| 47 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.04765359 |
| 48 | Pertussis_Homo sapiens_hsa05133 | 1.03280732 |
| 49 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.00455117 |
| 50 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.99271862 |
| 51 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.98381836 |
| 52 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.94394657 |
| 53 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.94082778 |
| 54 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.93991595 |
| 55 | Cell cycle_Homo sapiens_hsa04110 | 0.93135096 |
| 56 | HTLV-I infection_Homo sapiens_hsa05166 | 0.92490058 |
| 57 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.90534902 |
| 58 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.88905620 |
| 59 | * Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.88534760 |
| 60 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.88392516 |
| 61 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.88204055 |
| 62 | Colorectal cancer_Homo sapiens_hsa05210 | 0.86769812 |
| 63 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.86171934 |
| 64 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.86086932 |
| 65 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.82567986 |
| 66 | RNA degradation_Homo sapiens_hsa03018 | 0.81351583 |
| 67 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.80279524 |
| 68 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.78757090 |
| 69 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.78420949 |
| 70 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.78214779 |
| 71 | Salmonella infection_Homo sapiens_hsa05132 | 0.77356156 |
| 72 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.76152141 |
| 73 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.75919103 |
| 74 | Hepatitis C_Homo sapiens_hsa05160 | 0.74171489 |
| 75 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.73750705 |
| 76 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.71670322 |
| 77 | Malaria_Homo sapiens_hsa05144 | 0.70696026 |
| 78 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.68173634 |
| 79 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.66718137 |
| 80 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.66278257 |
| 81 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.63568926 |
| 82 | Asthma_Homo sapiens_hsa05310 | 0.63342771 |
| 83 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.60679150 |
| 84 | RNA transport_Homo sapiens_hsa03013 | 0.59558433 |
| 85 | Thyroid cancer_Homo sapiens_hsa05216 | 0.59429264 |
| 86 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.59040506 |
| 87 | Other glycan degradation_Homo sapiens_hsa00511 | 0.57906461 |
| 88 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.57487655 |
| 89 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.55868676 |
| 90 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.52694903 |
| 91 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.49106710 |
| 92 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.47498239 |
| 93 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.47398183 |
| 94 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.45578983 |
| 95 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.44682885 |
| 96 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.44404813 |
| 97 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.44317150 |
| 98 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.42557117 |
| 99 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.41593621 |
| 100 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.41196802 |
| 101 | RNA polymerase_Homo sapiens_hsa03020 | 0.41109863 |
| 102 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.40666893 |
| 103 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.40332557 |
| 104 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.40115443 |
| 105 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.39756976 |
| 106 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.38383620 |
| 107 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.38341526 |
| 108 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.38225064 |
| 109 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.37548087 |
| 110 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.36774907 |
| 111 | Lysosome_Homo sapiens_hsa04142 | 0.36057698 |
| 112 | Insulin resistance_Homo sapiens_hsa04931 | 0.35863968 |
| 113 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.34366503 |
| 114 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.33927491 |
| 115 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.33828699 |
| 116 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.30867717 |
| 117 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.30472347 |
| 118 | Amoebiasis_Homo sapiens_hsa05146 | 0.30242203 |
| 119 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.29515938 |
| 120 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.28572946 |
| 121 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.28453960 |
| 122 | Endocytosis_Homo sapiens_hsa04144 | 0.28077526 |
| 123 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.27945358 |
| 124 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.27564553 |
| 125 | Endometrial cancer_Homo sapiens_hsa05213 | 0.27349904 |
| 126 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.27183086 |
| 127 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.23796435 |

