SELM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.60869039
2type B pancreatic cell proliferation (GO:0044342)5.04058926
3extracellular fibril organization (GO:0043206)4.47741158
4synaptic vesicle exocytosis (GO:0016079)4.36846657
5collagen fibril organization (GO:0030199)4.34198916
6cell migration involved in heart development (GO:0060973)4.33970483
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.32583776
8regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.22227805
9skin morphogenesis (GO:0043589)4.20101124
10neuronal action potential propagation (GO:0019227)4.17670823
11adhesion of symbiont to host cell (GO:0044650)4.17485355
12virion attachment to host cell (GO:0019062)4.17485355
13keratan sulfate catabolic process (GO:0042340)4.15729520
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.14747976
15protein retention in ER lumen (GO:0006621)4.06607596
16kidney mesenchyme development (GO:0072074)4.02142167
17extracellular matrix assembly (GO:0085029)3.98210753
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.85855699
19sequestering of extracellular ligand from receptor (GO:0035581)3.85238180
20synaptic vesicle maturation (GO:0016188)3.83932172
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.83800912
22fibril organization (GO:0097435)3.82108238
23regulation of integrin-mediated signaling pathway (GO:2001044)3.78582591
24metanephric mesenchyme development (GO:0072075)3.72397762
25vocalization behavior (GO:0071625)3.66653154
26neuron cell-cell adhesion (GO:0007158)3.63695413
27regulation of synaptic vesicle exocytosis (GO:2000300)3.53218587
28glutamate secretion (GO:0014047)3.49796848
29adhesion of symbiont to host (GO:0044406)3.49089553
30COPI coating of Golgi vesicle (GO:0048205)3.44675091
31Golgi transport vesicle coating (GO:0048200)3.44675091
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41654883
33detection of calcium ion (GO:0005513)3.32441531
34neurotransmitter secretion (GO:0007269)3.28927085
35tooth mineralization (GO:0034505)3.26718440
36locomotory exploration behavior (GO:0035641)3.25554308
37mesenchymal-epithelial cell signaling (GO:0060638)3.24598098
38cellular response to zinc ion (GO:0071294)3.21371297
39regulation of extracellular matrix disassembly (GO:0010715)3.19646202
40chondrocyte proliferation (GO:0035988)3.18386532
41endocardial cushion development (GO:0003197)3.14514100
42protein localization to synapse (GO:0035418)3.13135007
43neuromuscular process controlling posture (GO:0050884)3.12788674
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12573616
45GDP-mannose metabolic process (GO:0019673)3.10768260
46regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.09726801
47presynaptic membrane assembly (GO:0097105)3.07745067
48presynaptic membrane organization (GO:0097090)3.07723221
49bone trabecula formation (GO:0060346)3.05427787
50postsynaptic membrane organization (GO:0001941)3.05154993
51endodermal cell differentiation (GO:0035987)3.03215012
52regulation of metalloenzyme activity (GO:0048552)3.02925296
53middle ear morphogenesis (GO:0042474)3.02206732
54barbed-end actin filament capping (GO:0051016)3.01414622
55regulation of synaptic vesicle transport (GO:1902803)2.97639724
56positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97466668
57synaptic transmission, glutamatergic (GO:0035249)2.94426417
58response to redox state (GO:0051775)2.93433769
59neuron-neuron synaptic transmission (GO:0007270)2.92995894
60axon ensheathment in central nervous system (GO:0032291)2.92472516
61central nervous system myelination (GO:0022010)2.92472516
62calcium-mediated signaling using intracellular calcium source (GO:0035584)2.91503174
63blood vessel maturation (GO:0001955)2.91065793
64cellular response to vitamin (GO:0071295)2.91028439
65extracellular regulation of signal transduction (GO:1900115)2.89745934
66extracellular negative regulation of signal transduction (GO:1900116)2.89745934
67synaptic vesicle docking involved in exocytosis (GO:0016081)2.89687531
68peptidyl-proline hydroxylation (GO:0019511)2.88942552
69regulation of vesicle fusion (GO:0031338)2.86990001
70negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84882105
71ionotropic glutamate receptor signaling pathway (GO:0035235)2.83180970
72cerebellar Purkinje cell differentiation (GO:0021702)2.82809293
73protein localization to cilium (GO:0061512)2.81665984
74neurotransmitter transport (GO:0006836)2.81043600
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.80376953
76smooth muscle tissue development (GO:0048745)2.79677541
77vascular endothelial growth factor signaling pathway (GO:0038084)2.78331888
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.78300020
79collagen metabolic process (GO:0032963)2.77437957
80gamma-aminobutyric acid signaling pathway (GO:0007214)2.77277414
81glutamate receptor signaling pathway (GO:0007215)2.76559357
82regulation of apoptotic process involved in morphogenesis (GO:1902337)2.76245361
83regulation of glutamate receptor signaling pathway (GO:1900449)2.75926867
84energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.75522964
85ATP hydrolysis coupled proton transport (GO:0015991)2.75522964
86transmission of nerve impulse (GO:0019226)2.75507819
87negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.74852435
88regulation of neuronal synaptic plasticity (GO:0048168)2.74719865
89lung vasculature development (GO:0060426)2.72802956
90regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.71906121
91negative regulation of cation channel activity (GO:2001258)2.71870539
92gamma-aminobutyric acid transport (GO:0015812)2.71691664
93basement membrane organization (GO:0071711)2.71362537
94negative regulation of microtubule polymerization (GO:0031115)2.71077364
95regulation of plasminogen activation (GO:0010755)2.70937989
96protein hydroxylation (GO:0018126)2.70691250
97regulation of synapse structural plasticity (GO:0051823)2.68708061
98mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68039271
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.68026270
100negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.67799577
101respiratory electron transport chain (GO:0022904)2.67591667
102regulation of voltage-gated calcium channel activity (GO:1901385)2.67083820
103neuromuscular synaptic transmission (GO:0007274)2.66904396
104positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66671212
105collagen catabolic process (GO:0030574)2.66188610
106electron transport chain (GO:0022900)2.66140069
107regulation of type B pancreatic cell apoptotic process (GO:2000674)2.65492294
108exploration behavior (GO:0035640)2.64884899
109neuron recognition (GO:0008038)2.64789848
110regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.64722224
111energy coupled proton transport, down electrochemical gradient (GO:0015985)2.63157578
112ATP synthesis coupled proton transport (GO:0015986)2.63157578
113dermatan sulfate biosynthetic process (GO:0030208)2.62186605
114dermatan sulfate metabolic process (GO:0030205)2.61799022
115negative regulation of nitric-oxide synthase activity (GO:0051001)2.60552527
116response to gravity (GO:0009629)2.60107586
117adult walking behavior (GO:0007628)2.60016039
118cerebellar granule cell differentiation (GO:0021707)2.58108057
119actin filament depolymerization (GO:0030042)2.57867592
120mating behavior (GO:0007617)2.57038098
121negative regulation of smooth muscle cell migration (GO:0014912)2.56617607
122multicellular organismal macromolecule metabolic process (GO:0044259)2.56140307
123protein maturation by protein folding (GO:0022417)2.55783431
124cerebellar Purkinje cell layer development (GO:0021680)2.55653020
125regulation of neurotransmitter levels (GO:0001505)2.55457778
126glomerular basement membrane development (GO:0032836)2.54927136
127long-term synaptic potentiation (GO:0060291)2.54717350
128regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.54690020
129regulation of long-term neuronal synaptic plasticity (GO:0048169)2.54684901
130transferrin transport (GO:0033572)2.54394946
131extracellular matrix organization (GO:0030198)2.54247070
132extracellular structure organization (GO:0043062)2.53261271
133extracellular matrix disassembly (GO:0022617)2.52915888
134neuronal action potential (GO:0019228)2.52015687
135peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.50257335
136neuronal ion channel clustering (GO:0045161)2.49989369
137behavioral response to cocaine (GO:0048148)2.49578897
138multicellular organismal catabolic process (GO:0044243)2.49473422
139synapse assembly (GO:0007416)2.49420879
140synaptic vesicle endocytosis (GO:0048488)2.49324195
141regulation of amyloid precursor protein catabolic process (GO:1902991)2.49240188
142membrane depolarization during action potential (GO:0086010)2.48692736
143negative regulation of neurotransmitter transport (GO:0051589)2.48633600
144regulation of neurotransmitter secretion (GO:0046928)2.48207794
145cell communication by electrical coupling (GO:0010644)2.47833125
146multicellular organismal metabolic process (GO:0044236)2.47807001
147positive regulation of synapse assembly (GO:0051965)2.47473002
148female mating behavior (GO:0060180)2.47351236
149endothelial cell morphogenesis (GO:0001886)2.47164931
150negative regulation of calcium ion transmembrane transport (GO:1903170)2.46915041
151negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.46915041
152positive regulation of receptor recycling (GO:0001921)2.46709961
153calcium ion-dependent exocytosis (GO:0017156)2.46682827
154activation of protein kinase A activity (GO:0034199)2.46140137
155positive regulation of pseudopodium assembly (GO:0031274)2.45391445
156response to pheromone (GO:0019236)2.43385878
157positive regulation of membrane potential (GO:0045838)2.43230676
158cellular potassium ion homeostasis (GO:0030007)2.42914501
159outer ear morphogenesis (GO:0042473)2.42886725
160synaptic vesicle transport (GO:0048489)2.42745863
161establishment of synaptic vesicle localization (GO:0097480)2.42745863
162G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41783734
163synaptic transmission (GO:0007268)2.40111934
164regulation of excitatory postsynaptic membrane potential (GO:0060079)2.38861852
165layer formation in cerebral cortex (GO:0021819)2.38368094
166ferric iron transport (GO:0015682)2.38281277
167trivalent inorganic cation transport (GO:0072512)2.38281277
168regulation of neurotransmitter transport (GO:0051588)2.37657219
169positive regulation of potassium ion transport (GO:0043268)2.37288179
170nucleotide-sugar biosynthetic process (GO:0009226)2.36730923
171regulation of calcium ion-dependent exocytosis (GO:0017158)2.36597610
172cell differentiation in hindbrain (GO:0021533)2.36575595
173positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.36197262
174adrenal gland development (GO:0030325)2.35500810
175negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.34380113
176positive regulation of fibroblast migration (GO:0010763)2.33542722
177positive regulation of protein targeting to membrane (GO:0090314)2.30860641
178apoptotic cell clearance (GO:0043277)2.30295412
179COPII vesicle coating (GO:0048208)2.27823171
180response to copper ion (GO:0046688)2.27421864
181cellular response to cadmium ion (GO:0071276)2.27337982
182muscle cell migration (GO:0014812)2.25652819
183regulation of collagen metabolic process (GO:0010712)2.24477156
184negative regulation of leukocyte chemotaxis (GO:0002689)2.24317707
185negative regulation of chondrocyte differentiation (GO:0032331)2.22567027
186cellular response to amino acid stimulus (GO:0071230)2.22061505
187substrate adhesion-dependent cell spreading (GO:0034446)2.19908521
188embryonic skeletal joint morphogenesis (GO:0060272)2.19583007
189positive regulation of actin filament depolymerization (GO:0030836)2.19471058
190positive regulation of blood vessel endothelial cell migration (GO:0043536)2.19068926
191endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.17357973
192vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.16921548
1934-hydroxyproline metabolic process (GO:0019471)2.16294183
194negative regulation of nitric oxide biosynthetic process (GO:0045019)2.16227898
195positive regulation of cartilage development (GO:0061036)2.15823107
196negative regulation of BMP signaling pathway (GO:0030514)2.14100519
197regulation of pseudopodium assembly (GO:0031272)2.14075562
198retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.13755665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.46367179
2RARG_19884340_ChIP-ChIP_MEFs_Mouse5.35479504
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.19650049
4TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.09440019
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09080881
6GBX2_23144817_ChIP-Seq_PC3_Human3.02166563
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86152401
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78607092
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78607092
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76432852
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76315607
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.73485385
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65089429
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.61682281
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59551707
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55925705
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51669362
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.50684955
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42713255
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.40043121
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.37627625
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37023879
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31602296
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20734349
25HIF1A_21447827_ChIP-Seq_MCF-7_Human2.15594938
26REST_21632747_ChIP-Seq_MESCs_Mouse2.13711117
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.11017169
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08732718
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05786453
30ELK3_25401928_ChIP-Seq_HUVEC_Human2.00198216
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.98329838
32DROSHA_22980978_ChIP-Seq_HELA_Human1.98079422
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94389110
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.92133642
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.90313850
36ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.89595866
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87920612
38CLOCK_20551151_ChIP-Seq_293T_Human1.84322920
39CJUN_26792858_Chip-Seq_BT549_Human1.77866397
40* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.75771052
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.74444928
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73697610
43LXR_22292898_ChIP-Seq_THP-1_Human1.72804095
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.72266962
45* RARB_27405468_Chip-Seq_BRAIN_Mouse1.68575226
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67694709
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67094955
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.63276091
49BRD4_25478319_ChIP-Seq_HGPS_Human1.62934785
50* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.59700028
51* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.53408538
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52374854
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51773779
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51549575
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50424622
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49872816
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.49496623
58RACK7_27058665_Chip-Seq_MCF-7_Human1.49472653
59JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49316572
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.42592906
61ZNF274_21170338_ChIP-Seq_K562_Hela1.41952917
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40353467
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39598671
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38432978
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38216933
66* TET1_21451524_ChIP-Seq_MESCs_Mouse1.37871606
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37179738
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.36514400
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35815402
70TAF15_26573619_Chip-Seq_HEK293_Human1.35394851
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34957864
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32895745
73* SA1_22415368_ChIP-Seq_MEFs_Mouse1.32046718
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31877020
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.31730644
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30379659
77SMAD4_21799915_ChIP-Seq_A2780_Human1.29937601
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29689156
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.28893106
80* TP53_22127205_ChIP-Seq_IMR90_Human1.28367861
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27710231
82SOX2_20726797_ChIP-Seq_SW620_Human1.26478373
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.25179156
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24715253
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24033711
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23627899
87MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22406375
88RXR_22158963_ChIP-Seq_LIVER_Mouse1.22384206
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17596744
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17109012
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16800684
92IGF1R_20145208_ChIP-Seq_DFB_Human1.15758788
93P300_19829295_ChIP-Seq_ESCs_Human1.14659467
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13855797
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13733615
96ATF3_27146783_Chip-Seq_COLON_Human1.13319251
97CSB_26484114_Chip-Seq_FIBROBLAST_Human1.10496774
98* TP53_23651856_ChIP-Seq_MEFs_Mouse1.10491806
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08975262
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07296018
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.05539259
102TP53_20018659_ChIP-ChIP_R1E_Mouse1.05467239
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04930900
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03927316
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.03427247
106AR_21572438_ChIP-Seq_LNCaP_Human1.03404614
107RNF2_27304074_Chip-Seq_NSC_Mouse1.02595179
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01860468
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01703493
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.01461900
111VDR_22108803_ChIP-Seq_LS180_Human1.00995381
112* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00224772
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98649270
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.98427607
115SMAD3_21741376_ChIP-Seq_EPCs_Human0.97013198
116PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96805559
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96654416
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95869532
119WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95447281
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95220363
121P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95081033
122SOX2_21211035_ChIP-Seq_LN229_Gbm0.93773742
123CTCF_20526341_ChIP-Seq_ESCs_Human0.93689436
124TBX20_22328084_ChIP-Seq_HEART_Mouse0.93653130
125TBX20_22080862_ChIP-Seq_HEART_Mouse0.93653130
126* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92386466
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92304311
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92304311
129CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91919711
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91161501
131ZNF263_19887448_ChIP-Seq_K562_Human0.90237152
132AHR_22903824_ChIP-Seq_MCF-7_Human0.88404761
133POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88203238
134TP63_22573176_ChIP-Seq_HFKS_Human0.87711737
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.87531938
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87264515
137ER_23166858_ChIP-Seq_MCF-7_Human0.86876179
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86476933
139ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86452871
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86452250
141EOMES_21245162_ChIP-Seq_HESCs_Human0.86176126
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85822467
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85626097
144AR_25329375_ChIP-Seq_VCAP_Human0.85560350
145ARNT_22903824_ChIP-Seq_MCF-7_Human0.85367309
146SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.84636015
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84593391
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83174465
149CTCF_27219007_Chip-Seq_Bcells_Human0.82846661
150RUNX2_22187159_ChIP-Seq_PCA_Human0.82841011
151FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82693795
152STAT3_23295773_ChIP-Seq_U87_Human0.82273192
153AR_19668381_ChIP-Seq_PC3_Human0.82189889
154UBF1/2_26484160_Chip-Seq_HMECs_Human0.81583241
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.81490005
156NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79327631
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79327631
158TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78303561
159TP53_18474530_ChIP-ChIP_U2OS_Human0.78239926
160PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78215625
161* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77867197
162UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77093287
163SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.75012573
164WT1_19549856_ChIP-ChIP_CCG9911_Human0.74980979
165NR3C1_21868756_ChIP-Seq_MCF10A_Human0.74004082
166* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.73541124
167YAP1_20516196_ChIP-Seq_MESCs_Mouse0.73534287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.80318803
2MP0001958_emphysema3.69243711
3MP0004272_abnormal_basement_membrane3.47245119
4MP0003880_abnormal_central_pattern3.33877649
5MP0004270_analgesia2.98872181
6MP0003635_abnormal_synaptic_transmissio2.91810391
7MP0006054_spinal_hemorrhage2.91040285
8MP0003705_abnormal_hypodermis_morpholog2.71869808
9MP0005257_abnormal_intraocular_pressure2.65325098
10MP0002272_abnormal_nervous_system2.53952779
11MP0009046_muscle_twitch2.47740770
12MP0009745_abnormal_behavioral_response2.43969212
13MP0002064_seizures2.41965712
14MP0002254_reproductive_system_inflammat2.34533137
15MP0002734_abnormal_mechanical_nocicepti2.32150064
16MP0005645_abnormal_hypothalamus_physiol2.25576702
17MP0000013_abnormal_adipose_tissue2.24302034
18MP0001968_abnormal_touch/_nociception2.21634932
19MP0002063_abnormal_learning/memory/cond2.16198882
20MP0002822_catalepsy2.12657655
21MP0009384_cardiac_valve_regurgitation2.11988109
22MP0006276_abnormal_autonomic_nervous2.09405497
23MP0002736_abnormal_nociception_after2.08332934
24MP0005508_abnormal_skeleton_morphology2.07648441
25MP0002572_abnormal_emotion/affect_behav2.04450309
26MP0009780_abnormal_chondrocyte_physiolo2.00488486
27MP0001486_abnormal_startle_reflex1.99427753
28MP0010030_abnormal_orbit_morphology1.98863050
29MP0010368_abnormal_lymphatic_system1.96576672
30MP0003950_abnormal_plasma_membrane1.96310960
31MP0010386_abnormal_urinary_bladder1.87496875
32MP0002735_abnormal_chemical_nociception1.87320268
33MP0003787_abnormal_imprinting1.84167020
34MP0003122_maternal_imprinting1.84060682
35MP0002184_abnormal_innervation1.82618635
36MP0001970_abnormal_pain_threshold1.81219783
37MP0002067_abnormal_sensory_capabilities1.75205709
38MP0002733_abnormal_thermal_nociception1.72148607
39MP0002837_dystrophic_cardiac_calcinosis1.71253941
40MP0005023_abnormal_wound_healing1.70920354
41MP0001440_abnormal_grooming_behavior1.69903903
42MP0001501_abnormal_sleep_pattern1.69539034
43MP0008569_lethality_at_weaning1.64603963
44MP0000767_abnormal_smooth_muscle1.64419163
45MP0005503_abnormal_tendon_morphology1.63422648
46MP0002060_abnormal_skin_morphology1.61487005
47MP0002909_abnormal_adrenal_gland1.57937845
48MP0005423_abnormal_somatic_nervous1.57849473
49MP0003566_abnormal_cell_adhesion1.56907845
50MP0001905_abnormal_dopamine_level1.56851650
51MP0005646_abnormal_pituitary_gland1.56626923
52MP0001984_abnormal_olfaction1.56072297
53MP0004142_abnormal_muscle_tone1.55368399
54MP0008438_abnormal_cutaneous_collagen1.53279239
55MP0005670_abnormal_white_adipose1.51850269
56MP0004043_abnormal_pH_regulation1.49590271
57MP0002557_abnormal_social/conspecific_i1.49268528
58MP0001243_abnormal_dermal_layer1.48353006
59MP0002933_joint_inflammation1.48348127
60MP0005394_taste/olfaction_phenotype1.48156408
61MP0005499_abnormal_olfactory_system1.48156408
62MP0003879_abnormal_hair_cell1.45100495
63MP0003283_abnormal_digestive_organ1.44991855
64MP0004858_abnormal_nervous_system1.44596308
65MP0000955_abnormal_spinal_cord1.43603337
66MP0000751_myopathy1.43412299
67MP0001529_abnormal_vocalization1.40742186
68MP0004145_abnormal_muscle_electrophysio1.39156003
69MP0008789_abnormal_olfactory_epithelium1.36814865
70MP0003329_amyloid_beta_deposits1.36297141
71MP0000778_abnormal_nervous_system1.34925616
72MP0009840_abnormal_foam_cell1.33518690
73MP0005171_absent_coat_pigmentation1.32320245
74MP0002882_abnormal_neuron_morphology1.30166706
75MP0005390_skeleton_phenotype1.29353513
76MP0004742_abnormal_vestibular_system1.29273296
77MP0000538_abnormal_urinary_bladder1.28877311
78MP0001485_abnormal_pinna_reflex1.27221549
79MP0005623_abnormal_meninges_morphology1.26687782
80MP0001879_abnormal_lymphatic_vessel1.25721084
81MP0005058_abnormal_lysosome_morphology1.24926975
82MP0009250_abnormal_appendicular_skeleto1.23369248
83MP0000003_abnormal_adipose_tissue1.21931034
84MP0001502_abnormal_circadian_rhythm1.21698484
85MP0003186_abnormal_redox_activity1.20882486
86MP0005386_behavior/neurological_phenoty1.20485109
87MP0004924_abnormal_behavior1.20485109
88MP0002066_abnormal_motor_capabilities/c1.19272145
89MP0004885_abnormal_endolymph1.17447586
90MP0004811_abnormal_neuron_physiology1.15116620
91MP0002876_abnormal_thyroid_physiology1.14724227
92MP0002896_abnormal_bone_mineralization1.14698297
93MP0001188_hyperpigmentation1.13716344
94MP0006072_abnormal_retinal_apoptosis1.13674335
95MP0005377_hearing/vestibular/ear_phenot1.11880396
96MP0003878_abnormal_ear_physiology1.11880396
97MP0001963_abnormal_hearing_physiology1.11825951
98MP0000681_abnormal_thyroid_gland1.08585456
99MP0003634_abnormal_glial_cell1.07945453
100MP0000920_abnormal_myelination1.07624032
101MP0002229_neurodegeneration1.06971877
102MP0001542_abnormal_bone_strength1.06662764
103MP0000343_altered_response_to1.05788555
104MP0001756_abnormal_urination1.04825645
105MP0000750_abnormal_muscle_regeneration1.03798374
106MP0005164_abnormal_response_to1.01483858
107MP0003633_abnormal_nervous_system0.99616622
108MP0003091_abnormal_cell_migration0.97515853
109MP0000163_abnormal_cartilage_morphology0.96588658
110MP0001986_abnormal_taste_sensitivity0.95804125
111MP0002752_abnormal_somatic_nervous0.95102567
112MP0003011_delayed_dark_adaptation0.92742560
113MP0004085_abnormal_heartbeat0.89756941
114MP0001661_extended_life_span0.89509877
115MP0000631_abnormal_neuroendocrine_gland0.89352617
116MP0001348_abnormal_lacrimal_gland0.88505082
117MP0005165_increased_susceptibility_to0.88490832
118MP0001299_abnormal_eye_distance/0.86308836
119MP0001664_abnormal_digestion0.84667077
120MP0003631_nervous_system_phenotype0.84174868
121MP0005551_abnormal_eye_electrophysiolog0.83772757
122MP0005275_abnormal_skin_tensile0.83532901
123MP0002115_abnormal_skeleton_extremities0.82108339
124MP0002877_abnormal_melanocyte_morpholog0.80788420
125MP0002152_abnormal_brain_morphology0.80412719
126MP0004510_myositis0.79522851
127MP0000026_abnormal_inner_ear0.79367419
128MP0000534_abnormal_ureter_morphology0.78307719
129MP0008775_abnormal_heart_ventricle0.76745654
130MP0003942_abnormal_urinary_system0.76692064
131MP0000762_abnormal_tongue_morphology0.76585457
132MP0001533_abnormal_skeleton_physiology0.75202425
133MP0000749_muscle_degeneration0.74376906
134MP0000462_abnormal_digestive_system0.73809681
135MP0003137_abnormal_impulse_conducting0.73792117
136MP0002638_abnormal_pupillary_reflex0.73554863
137MP0005375_adipose_tissue_phenotype0.73360043
138MP0005595_abnormal_vascular_smooth0.72746500
139MP0002069_abnormal_eating/drinking_beha0.72318212
140MP0005084_abnormal_gallbladder_morpholo0.71989129
141MP0004484_altered_response_of0.71634491
142MP0002751_abnormal_autonomic_nervous0.71294713
143MP0000759_abnormal_skeletal_muscle0.70908118
144MP0002295_abnormal_pulmonary_circulatio0.70220790
145MP0002108_abnormal_muscle_morphology0.70179548
146MP0000049_abnormal_middle_ear0.69441657
147MP0003279_aneurysm0.69238007
148MP0001944_abnormal_pancreas_morphology0.68503950
149MP0000230_abnormal_systemic_arterial0.68066518
150MP0000678_abnormal_parathyroid_gland0.67864343
151MP0002932_abnormal_joint_morphology0.66016998
152MP0002282_abnormal_trachea_morphology0.65393555
153MP0000604_amyloidosis0.64035829
154MP0003795_abnormal_bone_structure0.63456754
155MP0002113_abnormal_skeleton_development0.62524529
156MP0003448_altered_tumor_morphology0.62196937
157MP0002168_other_aberrant_phenotype0.61510361
158MP0005620_abnormal_muscle_contractility0.61320530
159MP0001881_abnormal_mammary_gland0.61310013
160MP0003075_altered_response_to0.60968133
161MP0001270_distended_abdomen0.60555120
162MP0005330_cardiomyopathy0.60312506
163MP0005360_urolithiasis0.59872353
164MP0000733_abnormal_muscle_development0.58860336
165MP0003191_abnormal_cellular_cholesterol0.57798461
166MP0010771_integument_phenotype0.56038286
167MP0005332_abnormal_amino_acid0.54622186
168MP0002128_abnormal_blood_circulation0.53048305
169MP0005369_muscle_phenotype0.50587729
170MP0005166_decreased_susceptibility_to0.49631068
171MP0001614_abnormal_blood_vessel0.48677867
172MP0008260_abnormal_autophagy0.46164402
173MP0000249_abnormal_blood_vessel0.45526379
174MP0000639_abnormal_adrenal_gland0.44453582
175MP0002133_abnormal_respiratory_system0.44248843

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)5.13146319
2Myokymia (HP:0002411)5.10951223
3Aortic dissection (HP:0002647)4.92680729
4Focal motor seizures (HP:0011153)4.70054440
5Atonic seizures (HP:0010819)4.40785456
6Follicular hyperkeratosis (HP:0007502)4.37081391
7Ankle contracture (HP:0006466)4.33411464
8Soft skin (HP:0000977)4.17100216
9Vertebral compression fractures (HP:0002953)4.06355007
10Vascular tortuosity (HP:0004948)4.03875540
11Type 1 muscle fiber predominance (HP:0003803)3.82959895
12Cervical subluxation (HP:0003308)3.81777510
13Bladder diverticulum (HP:0000015)3.80457062
14Focal seizures (HP:0007359)3.68265803
15Visual hallucinations (HP:0002367)3.68024597
16Acute necrotizing encephalopathy (HP:0006965)3.61614744
17Atrophic scars (HP:0001075)3.52105307
18Pheochromocytoma (HP:0002666)3.48331176
19Wormian bones (HP:0002645)3.43042821
20Abnormal mitochondria in muscle tissue (HP:0008316)3.28041433
21Spinal rigidity (HP:0003306)3.26101095
22Fragile skin (HP:0001030)3.25980736
23Genu recurvatum (HP:0002816)3.24937398
24Epileptic encephalopathy (HP:0200134)3.23281902
25Febrile seizures (HP:0002373)3.20685840
26Broad metatarsal (HP:0001783)3.20436272
27Slender build (HP:0001533)3.18767978
28Hypothermia (HP:0002045)3.15778172
29Joint stiffness (HP:0001387)3.10943200
30Blue sclerae (HP:0000592)3.09833986
31Neuroendocrine neoplasm (HP:0100634)3.08906251
32Progressive macrocephaly (HP:0004481)3.06757940
33Progressive cerebellar ataxia (HP:0002073)3.04588819
34Arterial tortuosity (HP:0005116)3.00319122
35Dilatation of the ascending aorta (HP:0005111)2.98150487
36Action tremor (HP:0002345)2.97006085
37Supranuclear gaze palsy (HP:0000605)2.89287073
38Absence seizures (HP:0002121)2.85696400
39Limb dystonia (HP:0002451)2.81912931
40Redundant skin (HP:0001582)2.76857321
41Mitochondrial inheritance (HP:0001427)2.74554016
42Anxiety (HP:0000739)2.74534905
43Acute encephalopathy (HP:0006846)2.73172876
44Retinal dysplasia (HP:0007973)2.73094872
45Neonatal short-limb short stature (HP:0008921)2.70050265
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.69237724
47Elbow flexion contracture (HP:0002987)2.67492772
48Bowel diverticulosis (HP:0005222)2.61961738
49Shallow orbits (HP:0000586)2.59734916
50Biconcave vertebral bodies (HP:0004586)2.59560898
51Dialeptic seizures (HP:0011146)2.58960213
52Hyperextensible skin (HP:0000974)2.56014624
53Generalized tonic-clonic seizures (HP:0002069)2.54658398
54Aortic regurgitation (HP:0001659)2.50718223
55Cerebral aneurysm (HP:0004944)2.48336115
56Nonimmune hydrops fetalis (HP:0001790)2.46749917
57Ankle clonus (HP:0011448)2.46094370
58Agitation (HP:0000713)2.43786105
59Mitral stenosis (HP:0001718)2.43733773
60Joint laxity (HP:0001388)2.43690601
61Mildly elevated creatine phosphokinase (HP:0008180)2.43477527
62Peritonitis (HP:0002586)2.43402826
63Bradycardia (HP:0001662)2.42521106
64Wrist flexion contracture (HP:0001239)2.40780030
65Gait imbalance (HP:0002141)2.40363044
66Infantile muscular hypotonia (HP:0008947)2.37600478
67Medial flaring of the eyebrow (HP:0010747)2.37223966
68Spondylolisthesis (HP:0003302)2.36311478
69Abnormality of dentin (HP:0010299)2.33719790
70Aortic valve stenosis (HP:0001650)2.33164293
71Delayed gross motor development (HP:0002194)2.32658850
72Generalized amyotrophy (HP:0003700)2.29990000
73Abnormal delivery (HP:0001787)2.29480135
74Abnormality of calcium-phosphate metabolism (HP:0100530)2.29163781
75Coronal craniosynostosis (HP:0004440)2.29127778
76Hypoventilation (HP:0002791)2.26154439
77Upper limb amyotrophy (HP:0009129)2.25622934
78Distal upper limb amyotrophy (HP:0007149)2.25622934
79Pulmonary artery stenosis (HP:0004415)2.25206499
80Stridor (HP:0010307)2.23915851
81Scanning speech (HP:0002168)2.21878587
82Congenital primary aphakia (HP:0007707)2.20477222
83Hypercortisolism (HP:0001578)2.20250568
84Ovoid vertebral bodies (HP:0003300)2.19408426
85Ulnar deviation of the wrist (HP:0003049)2.18249623
86Cardiovascular calcification (HP:0011915)2.18213605
87Abnormality of polysaccharide metabolism (HP:0011012)2.16682021
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16682021
89Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16682021
90Hepatocellular necrosis (HP:0001404)2.15939324
91Truncal ataxia (HP:0002078)2.15887522
92Aneurysm (HP:0002617)2.14805691
93Hand muscle atrophy (HP:0009130)2.14015158
94Narrow nasal bridge (HP:0000446)2.13583075
95Myotonia (HP:0002486)2.12100435
96Depression (HP:0000716)2.11857504
97Hyperparathyroidism (HP:0000843)2.11307485
98Ulnar bowing (HP:0003031)2.11165077
99Urinary glycosaminoglycan excretion (HP:0003541)2.10835386
100Mucopolysacchariduria (HP:0008155)2.10835386
101Wide anterior fontanel (HP:0000260)2.10741026
102Dysmetria (HP:0001310)2.08467377
103Neurofibrillary tangles (HP:0002185)2.07501142
104Abnormal eating behavior (HP:0100738)2.04115907
105Aplasia/Hypoplasia of the lens (HP:0008063)2.04056894
106Round ear (HP:0100830)2.03818550
107Hypoplasia of the odontoid process (HP:0003311)2.03443843
108Hydroureter (HP:0000072)2.03042483
109Increased CSF lactate (HP:0002490)2.02652070
110Mild short stature (HP:0003502)2.02212286
111Foot dorsiflexor weakness (HP:0009027)2.01164161
112Leukodystrophy (HP:0002415)2.00232789
113Osteolytic defects of the hand bones (HP:0009699)1.98516358
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.98516358
115Failure to thrive in infancy (HP:0001531)1.98000455
116Nephrogenic diabetes insipidus (HP:0009806)1.96531477
117Genital tract atresia (HP:0001827)1.96484142
118Vaginal atresia (HP:0000148)1.96312366
119Mitral regurgitation (HP:0001653)1.96282777
120Abnormality of proline metabolism (HP:0010907)1.96193197
121Hydroxyprolinuria (HP:0003080)1.96193197
122Ectopia lentis (HP:0001083)1.96012062
123Long toe (HP:0010511)1.95738092
124Premature skin wrinkling (HP:0100678)1.95362304
125Short nail (HP:0001799)1.94149816
126Dysostosis multiplex (HP:0000943)1.93276746
127Gaze-evoked nystagmus (HP:0000640)1.93050248
128Abnormality of skeletal muscle fiber size (HP:0012084)1.92351928
129Reduced subcutaneous adipose tissue (HP:0003758)1.91950914
130Prolonged QT interval (HP:0001657)1.90100625
131Mesomelia (HP:0003027)1.89496768
132Anosmia (HP:0000458)1.89395857
133Emphysema (HP:0002097)1.87705282
134Postural tremor (HP:0002174)1.87083749
135Nuclear cataract (HP:0100018)1.87038673
136Hemiparesis (HP:0001269)1.86749622
137Amblyopia (HP:0000646)1.85574450
138Distal lower limb muscle weakness (HP:0009053)1.85446982
139Glucose intolerance (HP:0000833)1.85137686
140Mitral valve prolapse (HP:0001634)1.82950113
141Premature rupture of membranes (HP:0001788)1.81653897
142Testicular atrophy (HP:0000029)1.81524291
143Abnormality of the odontoid process (HP:0003310)1.81223136
144Epileptiform EEG discharges (HP:0011182)1.81185555
145Increased connective tissue (HP:0009025)1.81135278
146Broad-based gait (HP:0002136)1.80915794
147Abnormality of the acetabulum (HP:0003170)1.80077134
148Ulnar claw (HP:0001178)1.79506290
149Osteoarthritis (HP:0002758)1.78810828
150Abnormality of the foot musculature (HP:0001436)1.78548749
151Torticollis (HP:0000473)1.78360509
152Optic disc pallor (HP:0000543)1.77757599
153EEG with generalized epileptiform discharges (HP:0011198)1.77546606
154Spinal cord compression (HP:0002176)1.77091295
155Split foot (HP:0001839)1.76977625
156Atelectasis (HP:0100750)1.76289317
157Delusions (HP:0000746)1.76162569
158Abnormality of glycolipid metabolism (HP:0010969)1.75894688
159Abnormality of glycosphingolipid metabolism (HP:0004343)1.75894688
160Abnormality of binocular vision (HP:0011514)1.74920958
161Diplopia (HP:0000651)1.74920958
162Hyperventilation (HP:0002883)1.74513019
163Adrenal overactivity (HP:0002717)1.74414068
164Cerebral inclusion bodies (HP:0100314)1.74370051
165Abnormal hair whorl (HP:0010721)1.71471628
166Hypsarrhythmia (HP:0002521)1.70580618
167Spinal canal stenosis (HP:0003416)1.69711037
168Dysdiadochokinesis (HP:0002075)1.69647302
169Decreased circulating renin level (HP:0003351)1.68805591
170Psychosis (HP:0000709)1.67749886
171Congenital glaucoma (HP:0001087)1.65458878
172Protrusio acetabuli (HP:0003179)1.65382121
173Focal dystonia (HP:0004373)1.65242885
174Spastic gait (HP:0002064)1.64299224
175Hyperinsulinemic hypoglycemia (HP:0000825)1.63909476
176Specific learning disability (HP:0001328)1.63840769
177Palpebral edema (HP:0100540)1.63050555
178Hepatic necrosis (HP:0002605)1.61699906
179Abnormality of magnesium homeostasis (HP:0004921)1.58918428
180Craniofacial dystonia (HP:0012179)1.58727152
181Increased circulating renin level (HP:0000848)1.58197930
182Megalencephaly (HP:0001355)1.58124162
183Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.57633606
184Degeneration of the lateral corticospinal tracts (HP:0002314)1.57633606
185Polyphagia (HP:0002591)1.57612810
186Neoplasm of the peripheral nervous system (HP:0100007)1.57379759
187Respiratory failure (HP:0002878)1.56980484
188Increased variability in muscle fiber diameter (HP:0003557)1.55959614
189Oligomenorrhea (HP:0000876)1.54666068
190Cortical visual impairment (HP:0100704)1.54560841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.30969059
2CASK3.04064152
3ARAF2.52069593
4ERN12.51921067
5EPHB22.43811054
6INSRR2.33593634
7MAP3K42.31921998
8MAP2K72.25485762
9BMPR22.12914157
10CAMKK22.09520640
11MAPKAPK32.08837910
12MAPK152.03941044
13ERBB32.00318084
14NTRK11.99759492
15MINK11.98621261
16ABL21.98515504
17PDGFRA1.95861922
18WNK41.84011011
19STK391.80589095
20MAP3K31.80011425
21MAP3K121.79025307
22PIM21.77996784
23PAK21.74669328
24LIMK11.73018775
25NME21.66817156
26GRK51.66064826
27ILK1.63538168
28PLK21.62541572
29OXSR11.62396502
30GRK11.60879499
31PRKD31.58146910
32MAP3K91.54795755
33PIK3CG1.54563163
34TGFBR21.54049591
35MAPKAPK51.49262546
36DDR21.46338731
37UHMK11.44599041
38EPHA41.42596160
39STK381.41607995
40PHKG11.40388707
41PHKG21.40388707
42PAK41.39195430
43CDK191.35954688
44CAMK2B1.34878178
45CAMK2D1.34538836
46NTRK21.33174064
47TTN1.32459612
48WNK11.32108854
49MARK11.30691784
50MAP2K41.30261608
51BCKDK1.30015532
52EPHA21.27969731
53MYLK1.25934085
54MUSK1.25852275
55NME11.19568712
56BCR1.19016353
57MAPK131.18673248
58FLT31.18278621
59KSR21.15874198
60CDK51.15057634
61PRKG21.14600656
62MAP3K21.13147978
63ROCK11.11793832
64PAK31.10554092
65CAMK2A1.10446670
66CAMK2G1.09526704
67DAPK21.09228659
68CAMKK11.09069434
69PAK61.08644033
70FER1.08327887
71SGK4941.07741738
72SGK2231.07741738
73PRKCE1.05179391
74PRKCG1.01968687
75PTK2B1.01916944
76PRPF4B1.00006947
77STK160.99087528
78CSNK1G20.95901590
79CDK140.95488772
80CSNK1G30.92349225
81BRAF0.91568087
82SIK10.86384381
83FRK0.85833357
84CDK180.85368842
85DAPK30.85252702
86SIK20.85145658
87EPHB10.84221324
88PNCK0.84137467
89CDK150.83191340
90CDC42BPA0.82312947
91TNIK0.81301093
92TAOK20.81250540
93TESK10.79680702
94SIK30.77985502
95GSK3A0.77658632
96PAK10.77257660
97MAP3K110.75988558
98CDK11A0.73140212
99PRKCH0.73020111
100MAP2K10.72961397
101PIK3CA0.72344395
102DMPK0.71724859
103GRK70.71478654
104TESK20.71008836
105PKN10.70897574
106TYK20.67771979
107MET0.67463380
108CSNK1A1L0.67332475
109ROCK20.66902992
110LMTK20.66281880
111MAP3K60.66265761
112NEK60.64936778
113HIPK20.64848235
114PKN20.63380647
115TBK10.63005414
116AKT30.62064684
117RET0.62015269
118WNK30.61528984
119ADRBK10.60443919
120TNK20.60328580
121MAP4K20.59020268
122MAP3K10.58953976
123TRPM70.57005250
124DAPK10.56990747
125TIE10.56663890
126MARK20.55517876
127CAMK10.55124673
128IRAK30.55006027
129PRKD20.54975624
130MOS0.54915793
131IRAK20.54376650
132TRIB30.52888371
133ADRBK20.51261696
134EPHA30.50653646
135DYRK1A0.50512495
136KIT0.50173833
137CSNK1G10.48910024
138LATS20.48909807
139JAK10.47224763
140PRKCI0.46460811
141PRKACA0.46231811
142PRKD10.45656080
143PDGFRB0.45268242
144RIPK10.44840149
145BMPR1B0.44668550
146MAPK70.42598151
147PTK20.40966503
148RPS6KA20.35357216
149MAP2K60.34569185
150MAPK40.33492089
151NEK90.32965102
152MAP3K130.32574873
153BRSK10.30086375
154PINK10.27836025
155SRC0.27089279
156PDK20.26898134
157PRKCD0.26627186

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.11375860
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.98249362
3Oxidative phosphorylation_Homo sapiens_hsa001902.84433808
4ECM-receptor interaction_Homo sapiens_hsa045122.78821363
5Nicotine addiction_Homo sapiens_hsa050332.65039913
6Sulfur relay system_Homo sapiens_hsa041222.57347492
7Collecting duct acid secretion_Homo sapiens_hsa049662.51061873
8Parkinsons disease_Homo sapiens_hsa050122.31788943
9GABAergic synapse_Homo sapiens_hsa047272.31030466
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28864093
11Olfactory transduction_Homo sapiens_hsa047402.28335313
12Other glycan degradation_Homo sapiens_hsa005112.25877133
13Vibrio cholerae infection_Homo sapiens_hsa051102.23693092
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.19807121
15Circadian entrainment_Homo sapiens_hsa047132.18931051
16Insulin secretion_Homo sapiens_hsa049112.16321338
17Taste transduction_Homo sapiens_hsa047422.10848045
18Alzheimers disease_Homo sapiens_hsa050102.07047378
19Morphine addiction_Homo sapiens_hsa050322.00010323
20Amphetamine addiction_Homo sapiens_hsa050311.98420283
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96282083
22Glutamatergic synapse_Homo sapiens_hsa047241.95117175
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.94362353
24Glutathione metabolism_Homo sapiens_hsa004801.86922889
25Protein export_Homo sapiens_hsa030601.86297317
26Dopaminergic synapse_Homo sapiens_hsa047281.85062156
27Focal adhesion_Homo sapiens_hsa045101.81910227
28Serotonergic synapse_Homo sapiens_hsa047261.79477631
29Cocaine addiction_Homo sapiens_hsa050301.76085092
30Long-term potentiation_Homo sapiens_hsa047201.75779191
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.74174630
32Cardiac muscle contraction_Homo sapiens_hsa042601.68645420
33Cholinergic synapse_Homo sapiens_hsa047251.67247024
34Folate biosynthesis_Homo sapiens_hsa007901.57116811
35Salivary secretion_Homo sapiens_hsa049701.56889896
36Proteasome_Homo sapiens_hsa030501.56850862
37Huntingtons disease_Homo sapiens_hsa050161.56850725
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55555487
39Long-term depression_Homo sapiens_hsa047301.48666511
40Gastric acid secretion_Homo sapiens_hsa049711.38306247
41N-Glycan biosynthesis_Homo sapiens_hsa005101.36812358
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36529816
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.35937805
44Galactose metabolism_Homo sapiens_hsa000521.22911187
45Sulfur metabolism_Homo sapiens_hsa009201.21005066
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19115713
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18381520
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16897092
49Gap junction_Homo sapiens_hsa045401.15174086
50Renin secretion_Homo sapiens_hsa049241.13434509
51Calcium signaling pathway_Homo sapiens_hsa040201.12807842
52Complement and coagulation cascades_Homo sapiens_hsa046101.10058869
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07090070
54Pancreatic secretion_Homo sapiens_hsa049721.04668176
55Fructose and mannose metabolism_Homo sapiens_hsa000511.03982433
56Oxytocin signaling pathway_Homo sapiens_hsa049211.03952648
57Vascular smooth muscle contraction_Homo sapiens_hsa042701.03917094
58GnRH signaling pathway_Homo sapiens_hsa049121.02698116
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01961248
60Arginine and proline metabolism_Homo sapiens_hsa003301.01022819
61Proteoglycans in cancer_Homo sapiens_hsa052050.97255815
62Vitamin B6 metabolism_Homo sapiens_hsa007500.96038790
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95962699
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88419276
65cAMP signaling pathway_Homo sapiens_hsa040240.87182233
66Type II diabetes mellitus_Homo sapiens_hsa049300.87169558
67Amoebiasis_Homo sapiens_hsa051460.86923585
68Phototransduction_Homo sapiens_hsa047440.86314545
69Phenylalanine metabolism_Homo sapiens_hsa003600.85556508
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84218138
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83680615
72Estrogen signaling pathway_Homo sapiens_hsa049150.83276894
73PPAR signaling pathway_Homo sapiens_hsa033200.82993438
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82787226
75Thyroid hormone synthesis_Homo sapiens_hsa049180.82287918
76Hedgehog signaling pathway_Homo sapiens_hsa043400.81596827
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81445399
78Rheumatoid arthritis_Homo sapiens_hsa053230.81124272
79Melanogenesis_Homo sapiens_hsa049160.80756925
80Axon guidance_Homo sapiens_hsa043600.80677597
81Renin-angiotensin system_Homo sapiens_hsa046140.78454803
82Dilated cardiomyopathy_Homo sapiens_hsa054140.77874427
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76698521
84Arachidonic acid metabolism_Homo sapiens_hsa005900.74774917
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.74420058
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74263226
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73924269
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73300982
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71454178
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69791550
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68875467
92Pertussis_Homo sapiens_hsa051330.67429035
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66921504
94Tyrosine metabolism_Homo sapiens_hsa003500.64249963
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63008453
96Phagosome_Homo sapiens_hsa041450.62313549
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61985913
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61353939
99Alcoholism_Homo sapiens_hsa050340.61101085
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60773338
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59242163
102Malaria_Homo sapiens_hsa051440.57175020
103Sphingolipid metabolism_Homo sapiens_hsa006000.56562630
104Ras signaling pathway_Homo sapiens_hsa040140.56303199
105Circadian rhythm_Homo sapiens_hsa047100.55412973
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55377191
107ErbB signaling pathway_Homo sapiens_hsa040120.54414209
108Glioma_Homo sapiens_hsa052140.53146307
109TGF-beta signaling pathway_Homo sapiens_hsa043500.52032868
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51790952
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51310303
112Melanoma_Homo sapiens_hsa052180.50369915
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49170823
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49130699
115Fat digestion and absorption_Homo sapiens_hsa049750.48828374
116Chemical carcinogenesis_Homo sapiens_hsa052040.48334298
117Metabolic pathways_Homo sapiens_hsa011000.47960554
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47091081
119Protein digestion and absorption_Homo sapiens_hsa049740.46953743
120Prion diseases_Homo sapiens_hsa050200.46220836
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45461715
122Lysosome_Homo sapiens_hsa041420.44575293
123Tryptophan metabolism_Homo sapiens_hsa003800.43703359
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43629669
125Mineral absorption_Homo sapiens_hsa049780.43538269
126Fatty acid elongation_Homo sapiens_hsa000620.43407234
127Peroxisome_Homo sapiens_hsa041460.43306855
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.43206228
129Type I diabetes mellitus_Homo sapiens_hsa049400.42966916
130Basal cell carcinoma_Homo sapiens_hsa052170.42592324
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42574341
132Glycerolipid metabolism_Homo sapiens_hsa005610.41907233
133Ovarian steroidogenesis_Homo sapiens_hsa049130.41027617
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40229814
135Glucagon signaling pathway_Homo sapiens_hsa049220.39518765
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39230049
137MAPK signaling pathway_Homo sapiens_hsa040100.38974143
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38628513
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38344252
140Tight junction_Homo sapiens_hsa045300.37336774
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36556489
142Ether lipid metabolism_Homo sapiens_hsa005650.36413845
143Rap1 signaling pathway_Homo sapiens_hsa040150.35411595
144Shigellosis_Homo sapiens_hsa051310.34559086
145Hippo signaling pathway_Homo sapiens_hsa043900.34356404
146Endocytosis_Homo sapiens_hsa041440.32993370
147Dorso-ventral axis formation_Homo sapiens_hsa043200.31287894
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30667476
149Regulation of autophagy_Homo sapiens_hsa041400.29573701

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