SELP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)8.63152229
2regulation of apoptotic cell clearance (GO:2000425)7.01963379
3neutrophil activation involved in immune response (GO:0002283)6.89725274
4leukocyte migration involved in inflammatory response (GO:0002523)6.37430540
5regulation of platelet aggregation (GO:0090330)6.32554321
6protein neddylation (GO:0045116)5.95166764
7blood coagulation, intrinsic pathway (GO:0007597)5.68218524
8platelet aggregation (GO:0070527)5.49606026
9complement activation, alternative pathway (GO:0006957)5.43531658
10negative regulation of homotypic cell-cell adhesion (GO:0034111)5.15902943
11regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)5.15251410
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.12266576
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.12266576
14mannose metabolic process (GO:0006013)5.08404379
15germinal center formation (GO:0002467)5.07791650
16* regulation of platelet activation (GO:0010543)5.06418967
17lipoxygenase pathway (GO:0019372)5.00478895
18negative regulation of platelet activation (GO:0010544)4.96470833
19apoptotic cell clearance (GO:0043277)4.91535000
20lymph vessel development (GO:0001945)4.84490404
21regulation of integrin-mediated signaling pathway (GO:2001044)4.70700298
22positive regulation of endothelial cell differentiation (GO:0045603)4.62065601
23transcytosis (GO:0045056)4.56010104
24positive regulation of mast cell activation (GO:0033005)4.55198898
25endothelial cell chemotaxis (GO:0035767)4.52321344
26negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.51336427
27antigen processing and presentation of endogenous antigen (GO:0019883)4.50917151
28* regulation of integrin activation (GO:0033623)4.45652566
29adenosine receptor signaling pathway (GO:0001973)4.45006022
30definitive hemopoiesis (GO:0060216)4.44343554
31detection of molecule of bacterial origin (GO:0032490)4.35579023
32* leukocyte tethering or rolling (GO:0050901)4.32729352
33neutrophil activation (GO:0042119)4.30564517
34negative regulation of granulocyte differentiation (GO:0030853)4.27100102
35negative regulation of thymocyte apoptotic process (GO:0070244)4.25016784
36cellular extravasation (GO:0045123)4.21718162
37response to interferon-beta (GO:0035456)4.17858926
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.09305309
39G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.09221225
40negative regulation of norepinephrine secretion (GO:0010700)4.07617289
41negative regulation of erythrocyte differentiation (GO:0045647)4.07401288
42opsonization (GO:0008228)4.06633425
43negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.06119010
44protein kinase C signaling (GO:0070528)4.05199559
45production of molecular mediator involved in inflammatory response (GO:0002532)4.02066229
46homotypic cell-cell adhesion (GO:0034109)3.89049247
47* platelet degranulation (GO:0002576)3.83319511
48citrulline biosynthetic process (GO:0019240)3.81783901
49negative regulation of heart rate (GO:0010459)3.76943984
50response to interferon-alpha (GO:0035455)3.74780628
51granulocyte activation (GO:0036230)3.73622469
52regulation of endothelial cell chemotaxis (GO:2001026)3.73414785
53negative regulation of T-helper cell differentiation (GO:0045623)3.73274913
54negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.73274913
55regulation of lipoprotein metabolic process (GO:0050746)3.72295646
56positive regulation of systemic arterial blood pressure (GO:0003084)3.70826835
57megakaryocyte development (GO:0035855)3.70805066
58positive regulation of T cell chemotaxis (GO:0010820)3.70286916
59regulation of T cell chemotaxis (GO:0010819)3.70286916
60* platelet activation (GO:0030168)3.68057732
61purinergic nucleotide receptor signaling pathway (GO:0035590)3.67981409
62regulation of homotypic cell-cell adhesion (GO:0034110)3.64622853
63regulation of humoral immune response (GO:0002920)3.62720846
64platelet formation (GO:0030220)3.55068388
65secretory granule organization (GO:0033363)3.53210110
66blood vessel maturation (GO:0001955)3.51409645
67positive regulation of receptor recycling (GO:0001921)3.51162293
68regulation of complement activation (GO:0030449)3.49367168
69detection of external biotic stimulus (GO:0098581)3.48381866
70positive regulation of cAMP-mediated signaling (GO:0043950)3.47732121
71interleukin-6-mediated signaling pathway (GO:0070102)3.47033285
72negative regulation of interleukin-12 production (GO:0032695)3.45607600
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.45484933
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.44304804
75positive regulation of macrophage differentiation (GO:0045651)3.44013507
76antigen processing and presentation via MHC class Ib (GO:0002475)3.41567636
77negative regulation of endothelial cell migration (GO:0010596)3.39673991
78angiogenesis involved in wound healing (GO:0060055)3.39326594
79regulation of Golgi to plasma membrane protein transport (GO:0042996)3.38091145
80regulation of macrophage derived foam cell differentiation (GO:0010743)3.36498937
81regulation of B cell receptor signaling pathway (GO:0050855)3.36185668
82complement activation (GO:0006956)3.35487802
83cyclooxygenase pathway (GO:0019371)3.33698035
84cellular response to interleukin-6 (GO:0071354)3.33008509
85low-density lipoprotein particle remodeling (GO:0034374)3.32444183
86positive regulation of Rho protein signal transduction (GO:0035025)3.32386158
87regulation of MHC class II biosynthetic process (GO:0045346)3.32227258
88lymph node development (GO:0048535)3.31183283
89positive regulation of Rap GTPase activity (GO:0032854)3.31127900
90negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.29481147
91positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.29152740
92regulation of macrophage chemotaxis (GO:0010758)3.28795789
93ribosomal small subunit assembly (GO:0000028)3.28456944
94positive regulation of granulocyte differentiation (GO:0030854)3.28379508
95extracellular fibril organization (GO:0043206)3.27564769
96positive regulation of gamma-delta T cell activation (GO:0046645)3.27469712
97regulation of protein activation cascade (GO:2000257)3.26158420
98negative regulation of appetite (GO:0032099)3.25847624
99negative regulation of response to food (GO:0032096)3.25847624
100autophagic vacuole fusion (GO:0000046)3.23498237
101protein activation cascade (GO:0072376)3.20990645
102regulation of endothelial cell differentiation (GO:0045601)3.20105985
103positive regulation of cell adhesion mediated by integrin (GO:0033630)3.19329735
104regulation of mast cell activation (GO:0033003)3.19144256
105regulation of cellular extravasation (GO:0002691)3.18458887
106regulation of regulatory T cell differentiation (GO:0045589)3.18421316
107negative regulation of bone mineralization (GO:0030502)3.17887577
108relaxation of smooth muscle (GO:0044557)3.16511246
109negative regulation of T cell apoptotic process (GO:0070233)3.15062186
110regulation of T-helper 1 cell differentiation (GO:0045625)3.13686219
111adhesion of symbiont to host (GO:0044406)3.13528962
112regulation of mast cell degranulation (GO:0043304)3.11777916
113negative regulation of macrophage differentiation (GO:0045650)3.09829241
114chronic inflammatory response (GO:0002544)3.09693904
115endothelial tube morphogenesis (GO:0061154)3.08901520
116morphogenesis of an endothelium (GO:0003159)3.08901520
117positive regulation of mast cell degranulation (GO:0043306)3.08226314
118positive regulation of mast cell activation involved in immune response (GO:0033008)3.08226314
119purinergic receptor signaling pathway (GO:0035587)3.07843071
120fusion of sperm to egg plasma membrane (GO:0007342)3.07812909
121negative regulation of neural precursor cell proliferation (GO:2000178)3.07490923
122positive regulation of respiratory burst (GO:0060267)3.07279341
123platelet dense granule organization (GO:0060155)3.07125545
124phagocytosis, engulfment (GO:0006911)3.04941688
125Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04493802
126G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.03548788
127negative regulation of nitric oxide biosynthetic process (GO:0045019)3.03182436
128regulation of female receptivity (GO:0045924)3.01544351
129regulation of mast cell activation involved in immune response (GO:0033006)3.00872073
130polyamine biosynthetic process (GO:0006596)3.00684192
131regulation of T cell migration (GO:2000404)3.00674025
132response to type I interferon (GO:0034340)3.00637509
133cytokine production involved in immune response (GO:0002367)2.97984730
134positive regulation of B cell differentiation (GO:0045579)2.95211738
135ovulation from ovarian follicle (GO:0001542)2.93205380
136negative regulation of viral entry into host cell (GO:0046597)2.92961515
137type I interferon signaling pathway (GO:0060337)2.92543469
138cellular response to type I interferon (GO:0071357)2.92543469
139regulation of phagocytosis (GO:0050764)2.92139304
140cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.92107125
141regulation of memory T cell differentiation (GO:0043380)2.92084637
142fibril organization (GO:0097435)2.90271356
143negative regulation of protein localization to cell surface (GO:2000009)2.88958928
144detection of biotic stimulus (GO:0009595)2.88445780
145vascular endothelial growth factor signaling pathway (GO:0038084)2.87923602
146glomerular filtration (GO:0003094)2.87833055
147peptide catabolic process (GO:0043171)2.87676091
148regulation of cholesterol storage (GO:0010885)2.86875554
149myeloid cell development (GO:0061515)2.85865044
150negative regulation of stress fiber assembly (GO:0051497)2.85214576
151negative regulation of heart contraction (GO:0045822)2.83570046
152positive regulation of antigen processing and presentation (GO:0002579)2.83501178
153regulation of inositol phosphate biosynthetic process (GO:0010919)2.82574175
154leukocyte degranulation (GO:0043299)2.82368839
155establishment of endothelial barrier (GO:0061028)2.81770015
156* regulation of blood coagulation (GO:0030193)2.80458376
157* regulation of hemostasis (GO:1900046)2.80458376
158termination of G-protein coupled receptor signaling pathway (GO:0038032)2.80112741
159endothelial cell morphogenesis (GO:0001886)2.80080902
160mesodermal cell differentiation (GO:0048333)2.79694659
161negative regulation of blood vessel endothelial cell migration (GO:0043537)2.76814359
162regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.76773260
163regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.76614013
164regulation of gamma-delta T cell differentiation (GO:0045586)2.76603954
165positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.76161541
166mature B cell differentiation involved in immune response (GO:0002313)2.75718204
167termination of signal transduction (GO:0023021)2.75182107
168negative regulation of biomineral tissue development (GO:0070168)2.74392576
169negative regulation of interleukin-17 production (GO:0032700)2.73739297
170* leukocyte cell-cell adhesion (GO:0007159)2.73546256
171cGMP-mediated signaling (GO:0019934)2.73143180
172antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.72178074
173regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71343905
174regulation of receptor recycling (GO:0001919)2.70591547
175leukotriene metabolic process (GO:0006691)2.69121629
176endothelium development (GO:0003158)2.69110559
177cell adhesion mediated by integrin (GO:0033627)2.68525093
178negative regulation of calcium ion transport into cytosol (GO:0010523)2.67152330
179organelle membrane fusion (GO:0090174)2.67056790
180positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.67029969
181positive regulation of immunoglobulin mediated immune response (GO:0002891)2.66489091
182positive regulation of B cell mediated immunity (GO:0002714)2.66489091
183negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.66275426
184response to protozoan (GO:0001562)2.66269104
185lymphangiogenesis (GO:0001946)2.65542861
186regulation of T-helper 2 cell differentiation (GO:0045628)2.64637849
187* positive regulation of hemostasis (GO:1900048)2.64502252
188* positive regulation of blood coagulation (GO:0030194)2.64502252
189regulation of antigen processing and presentation (GO:0002577)2.64384392
190icosanoid biosynthetic process (GO:0046456)2.63524645
191fatty acid derivative biosynthetic process (GO:1901570)2.63524645
192positive regulation of receptor internalization (GO:0002092)2.61285493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human3.89781917
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.36817410
3GATA2_21666600_ChIP-Seq_HMVEC_Human2.92476915
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86534130
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74046438
6GATA1_22025678_ChIP-Seq_K562_Human2.70959661
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64092057
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.63910265
9* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.62371614
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56057578
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.48812146
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.47654761
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39947611
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.29451477
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27745844
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25100338
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.23448103
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15243136
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.10818922
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07991760
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07483024
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05000958
23BP1_19119308_ChIP-ChIP_Hs578T_Human12.1706805
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94073785
25* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92726740
26TCF7_22412390_ChIP-Seq_EML_Mouse1.91612339
27MYC_22102868_ChIP-Seq_BL_Human1.90935846
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.88662407
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85765072
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.82570939
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.77915671
32CLOCK_20551151_ChIP-Seq_293T_Human1.77070627
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74683475
34RUNX_20019798_ChIP-Seq_JUKART_Human1.71768487
35* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70600110
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69258100
37SPI1_23127762_ChIP-Seq_K562_Human1.65834531
38VDR_24763502_ChIP-Seq_THP-1_Human1.62949869
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61897260
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61210761
41GATA1_19941827_ChIP-Seq_MEL86_Mouse1.60490104
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.59371203
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.58923650
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56510535
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.55262481
46HTT_18923047_ChIP-ChIP_STHdh_Human1.54951764
47* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53945495
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.52858295
49VDR_21846776_ChIP-Seq_THP-1_Human1.50889399
50GATA1_19941826_ChIP-Seq_K562_Human1.50191252
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49516428
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48631557
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48151898
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48138899
55SPI1_23547873_ChIP-Seq_NB4_Human1.45443048
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44176128
57MAF_26560356_Chip-Seq_TH1_Human1.42333403
58EZH2_22144423_ChIP-Seq_EOC_Human1.42255581
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.41279755
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39673232
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39103980
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37782879
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37781764
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37063940
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34292298
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.31359807
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30033246
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29234385
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28043404
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27302855
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27192571
72MYB_26560356_Chip-Seq_TH2_Human1.26621322
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25032895
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23105982
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.22335080
76GBX2_23144817_ChIP-Seq_PC3_Human1.21322659
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19977687
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.19790552
79UTX_26944678_Chip-Seq_JUKART_Human1.19526157
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17468690
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16209558
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12801802
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12801802
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12540504
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12540504
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12540504
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.11577415
88GATA2_19941826_ChIP-Seq_K562_Human1.11537276
89KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.11106682
90MYB_26560356_Chip-Seq_TH1_Human1.09782614
91GATA3_27048872_Chip-Seq_THYMUS_Human1.09781305
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09276371
93KDM2B_26808549_Chip-Seq_DND41_Human1.06169538
94CDX2_20551321_ChIP-Seq_CACO-2_Human1.05477222
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05133437
96LXR_22292898_ChIP-Seq_THP-1_Human1.04533183
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03595120
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02274926
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00482537
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00322343
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99691203
102ETS1_22383799_ChIP-Seq_G1ME_Mouse0.99529227
103EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98836273
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98803285
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97941732
106NCOR1_26117541_ChIP-Seq_K562_Human0.97600001
107SALL4_22934838_ChIP-ChIP_CD34+_Human0.95391679
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94258110
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93440789
110VDR_24787735_ChIP-Seq_THP-1_Human0.93026564
111PU_27001747_Chip-Seq_BMDM_Mouse0.91609591
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90871497
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90554953
114POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89937808
115GATA3_26560356_Chip-Seq_TH2_Human0.89869979
116SMAD_19615063_ChIP-ChIP_OVARY_Human0.89746896
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89668592
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.87869169
119TCF4_18268006_ChIP-ChIP_LS174T_Human0.85674968
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85337543
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.85157198
122TAF15_26573619_Chip-Seq_HEK293_Human0.84348796
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84112370
124JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84018648
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83256612
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82967657
127RACK7_27058665_Chip-Seq_MCF-7_Human0.82860641
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81086618
129SPI1_20517297_ChIP-Seq_HL60_Human0.79457831
130MAF_26560356_Chip-Seq_TH2_Human0.78961031
131SOX2_20726797_ChIP-Seq_SW620_Human0.77180565
132CJUN_26792858_Chip-Seq_BT549_Human0.77034251
133* LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75643566
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75360390
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74902092
136VDR_22108803_ChIP-Seq_LS180_Human0.74748644
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.73188321
138FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73031614
139OCT1_27270436_Chip-Seq_PROSTATE_Human0.71342295
140GATA3_21878914_ChIP-Seq_MCF-7_Human0.70783941
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.70720769
142SMRT_27268052_Chip-Seq_Bcells_Human0.69911520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.13715838
2* MP0003724_increased_susceptibility_to4.20005251
3MP0006054_spinal_hemorrhage3.63031492
4MP0001879_abnormal_lymphatic_vessel3.15855600
5MP0008004_abnormal_stomach_pH2.89376700
6MP0002396_abnormal_hematopoietic_system2.70331003
7MP0009278_abnormal_bone_marrow2.70273775
8MP0003303_peritoneal_inflammation2.63691387
9MP0000465_gastrointestinal_hemorrhage2.53111511
10MP0005167_abnormal_blood-brain_barrier2.52561337
11MP0004084_abnormal_cardiac_muscle2.50776760
12* MP0001851_eye_inflammation2.41860370
13MP0003300_gastrointestinal_ulcer2.38608599
14MP0005464_abnormal_platelet_physiology2.37176910
15MP0004808_abnormal_hematopoietic_stem2.36129782
16MP0003436_decreased_susceptibility_to2.27724398
17MP0002419_abnormal_innate_immunity2.09084800
18MP0000685_abnormal_immune_system2.08588062
19MP0005083_abnormal_biliary_tract2.07759007
20* MP0005025_abnormal_response_to2.07660863
21MP0000767_abnormal_smooth_muscle2.00138865
22MP0000230_abnormal_systemic_arterial1.95369657
23MP0001545_abnormal_hematopoietic_system1.89943885
24MP0005397_hematopoietic_system_phenotyp1.89943885
25MP0009785_altered_susceptibility_to1.87632207
26MP0001790_abnormal_immune_system1.85392659
27MP0005387_immune_system_phenotype1.85392659
28MP0003075_altered_response_to1.81897023
29MP0001835_abnormal_antigen_presentation1.81145438
30MP0000343_altered_response_to1.80790657
31MP0004272_abnormal_basement_membrane1.78005938
32* MP0001533_abnormal_skeleton_physiology1.77896790
33* MP0002148_abnormal_hypersensitivity_rea1.75183279
34MP0003828_pulmonary_edema1.73886515
35MP0004036_abnormal_muscle_relaxation1.71190273
36MP0008775_abnormal_heart_ventricle1.70258762
37MP0000249_abnormal_blood_vessel1.69768826
38MP0003566_abnormal_cell_adhesion1.66837395
39MP0004947_skin_inflammation1.61358163
40MP0004510_myositis1.59730402
41MP0003191_abnormal_cellular_cholesterol1.59403859
42* MP0005000_abnormal_immune_tolerance1.57040192
43MP0003638_abnormal_response/metabolism_1.56869458
44MP0003279_aneurysm1.55694294
45* MP0001800_abnormal_humoral_immune1.54982766
46MP0001873_stomach_inflammation1.54801517
47* MP0002452_abnormal_antigen_presenting1.49112307
48MP0003705_abnormal_hypodermis_morpholog1.46147080
49MP0001915_intracranial_hemorrhage1.45653320
50MP0004130_abnormal_muscle_cell1.45485535
51MP0002405_respiratory_system_inflammati1.44604029
52MP0002736_abnormal_nociception_after1.40820421
53* MP0002420_abnormal_adaptive_immunity1.40751937
54MP0002933_joint_inflammation1.39700743
55* MP0001819_abnormal_immune_cell1.38337151
56MP0005670_abnormal_white_adipose1.35756103
57MP0005023_abnormal_wound_healing1.35444954
58* MP0002723_abnormal_immune_serum1.35114300
59MP0002166_altered_tumor_susceptibility1.32915606
60MP0005058_abnormal_lysosome_morphology1.31533340
61MP0002132_abnormal_respiratory_system1.30100129
62MP0010155_abnormal_intestine_physiology1.30051566
63MP0001845_abnormal_inflammatory_respons1.28166576
64* MP0000689_abnormal_spleen_morphology1.25637470
65MP0005409_darkened_coat_color1.23563662
66MP0009333_abnormal_splenocyte_physiolog1.19851984
67MP0005646_abnormal_pituitary_gland1.19486924
68MP0002398_abnormal_bone_marrow1.18752197
69MP0005410_abnormal_fertilization1.18277886
70MP0003448_altered_tumor_morphology1.17995570
71MP0000716_abnormal_immune_system1.17489188
72MP0003943_abnormal_hepatobiliary_system1.15126804
73MP0002138_abnormal_hepatobiliary_system1.13375617
74* MP0005390_skeleton_phenotype1.13207572
75MP0003656_abnormal_erythrocyte_physiolo1.13178069
76MP0009697_abnormal_copulation1.13100532
77MP0008469_abnormal_protein_level1.12993292
78MP0009840_abnormal_foam_cell1.12381785
79MP0008438_abnormal_cutaneous_collagen1.12342737
80MP0004484_altered_response_of1.11698789
81MP0002722_abnormal_immune_system1.10687738
82MP0009763_increased_sensitivity_to1.10292179
83MP0002429_abnormal_blood_cell1.09878113
84* MP0001614_abnormal_blood_vessel1.06688619
85MP0001853_heart_inflammation1.05047605
86MP0008872_abnormal_physiological_respon1.04281069
87MP0002877_abnormal_melanocyte_morpholog1.03835138
88MP0008874_decreased_physiological_sensi1.01641410
89MP0002733_abnormal_thermal_nociception1.00828527
90MP0000858_altered_metastatic_potential0.99824887
91MP0005166_decreased_susceptibility_to0.99212039
92MP0003091_abnormal_cell_migration0.99081661
93MP0001664_abnormal_digestion0.96140641
94* MP0002128_abnormal_blood_circulation0.95283565
95MP0002254_reproductive_system_inflammat0.94704810
96MP0009765_abnormal_xenobiotic_induced0.92998907
97MP0010352_gastrointestinal_tract_polyps0.92961822
98MP0010329_abnormal_lipoprotein_level0.92249713
99MP0004147_increased_porphyrin_level0.90463202
100MP0006138_congestive_heart_failure0.86864778
101MP0001544_abnormal_cardiovascular_syste0.86455305
102MP0005385_cardiovascular_system_phenoty0.86455305
103MP0009764_decreased_sensitivity_to0.84931226
104MP0005164_abnormal_response_to0.84302881
105MP0005535_abnormal_body_temperature0.83918709
106MP0001968_abnormal_touch/_nociception0.83342505
107MP0005165_increased_susceptibility_to0.83229378
108MP0003763_abnormal_thymus_physiology0.82151690
109MP0000015_abnormal_ear_pigmentation0.82101142
110MP0002006_tumorigenesis0.82002154
111MP0003879_abnormal_hair_cell0.81773897
112* MP0009642_abnormal_blood_homeostasis0.81014628
113MP0004883_abnormal_blood_vessel0.80744554
114MP0002925_abnormal_cardiovascular_devel0.79871057
115MP0005381_digestive/alimentary_phenotyp0.79862635
116MP0004215_abnormal_myocardial_fiber0.78349298
117* MP0000598_abnormal_liver_morphology0.77934833
118MP0002972_abnormal_cardiac_muscle0.77544508
119MP0001849_ear_inflammation0.77154623
120MP0005319_abnormal_enzyme/_coenzyme0.77139108
121MP0001663_abnormal_digestive_system0.76122387
122MP0005666_abnormal_adipose_tissue0.76051565
123MP0005671_abnormal_response_to0.75729779
124MP0001958_emphysema0.73564207
125MP0000703_abnormal_thymus_morphology0.71518459
126MP0003866_abnormal_defecation0.67899802
127MP0002998_abnormal_bone_remodeling0.67319242
128MP0005084_abnormal_gallbladder_morpholo0.67117235
129MP0005595_abnormal_vascular_smooth0.65912326
130MP0008873_increased_physiological_sensi0.65755019
131MP0000609_abnormal_liver_physiology0.65082794
132MP0005623_abnormal_meninges_morphology0.63494950
133MP0009931_abnormal_skin_appearance0.63389424
134MP0000490_abnormal_crypts_of0.62072169

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.91491015
2Spontaneous hematomas (HP:0007420)5.07208057
3Abnormality of the nasal mucosa (HP:0000433)5.06332493
4Prolonged bleeding time (HP:0003010)5.01650534
5Hyperlipoproteinemia (HP:0010980)4.81945378
6Menorrhagia (HP:0000132)4.81788912
7Abnormality of complement system (HP:0005339)4.35303545
8Glomerulonephritis (HP:0000099)4.33635036
9Joint hemorrhage (HP:0005261)4.26244903
10Complement deficiency (HP:0004431)4.13536480
11Deep venous thrombosis (HP:0002625)4.10458916
12Poikilocytosis (HP:0004447)4.03890428
13Vacuolated lymphocytes (HP:0001922)3.99767983
14Spondylolisthesis (HP:0003302)3.85013438
15Nasal polyposis (HP:0100582)3.77468148
16Epistaxis (HP:0000421)3.70626422
17Hematochezia (HP:0002573)3.59555993
18Dyschromatopsia (HP:0007641)3.53705568
19Acanthocytosis (HP:0001927)3.51891250
20Esophageal varix (HP:0002040)3.40658459
21Peritonitis (HP:0002586)3.38111046
22Cervical subluxation (HP:0003308)3.27752418
23Dysostosis multiplex (HP:0000943)3.24304916
24Broad metatarsal (HP:0001783)3.20957130
25Myositis (HP:0100614)3.19659165
26Abnormality of the heme biosynthetic pathway (HP:0010472)3.19330343
27Shallow orbits (HP:0000586)3.13682083
28Impaired platelet aggregation (HP:0003540)3.13605675
29Abnormal platelet function (HP:0011869)3.13605675
30Recurrent gram-negative bacterial infections (HP:0005420)3.13604065
31Thrombocytosis (HP:0001894)3.09244773
32Nonimmune hydrops fetalis (HP:0001790)3.05972801
33Abnormal pupillary function (HP:0007686)3.04819874
34Recurrent abscess formation (HP:0002722)3.02744886
35Abnormality of the common coagulation pathway (HP:0010990)2.98268822
36Cerebral aneurysm (HP:0004944)2.91429601
37Nephritis (HP:0000123)2.89204787
38Prolonged partial thromboplastin time (HP:0003645)2.83756092
39Elevated erythrocyte sedimentation rate (HP:0003565)2.81428210
40Increased density of long bones (HP:0006392)2.79960181
41Stomatitis (HP:0010280)2.79571177
42Short nail (HP:0001799)2.79556626
43Cellulitis (HP:0100658)2.77961386
44Polygenic inheritance (HP:0010982)2.75445536
45Thoracic kyphosis (HP:0002942)2.71220836
46Enlarged penis (HP:0000040)2.70379458
47IgM deficiency (HP:0002850)2.70256977
48Polycythemia (HP:0001901)2.70019744
49Loss of speech (HP:0002371)2.69249189
50Urinary glycosaminoglycan excretion (HP:0003541)2.69177586
51Mucopolysacchariduria (HP:0008155)2.69177586
52Abnormality of the intrinsic pathway (HP:0010989)2.68815260
53Eczematoid dermatitis (HP:0000976)2.64423838
54Purpura (HP:0000979)2.63678596
55Asymmetric septal hypertrophy (HP:0001670)2.60221907
56Paralysis (HP:0003470)2.55213462
57Beaking of vertebral bodies (HP:0004568)2.55051990
58Pustule (HP:0200039)2.54351441
59Chronic otitis media (HP:0000389)2.53383159
60Abnormality of the lumbar spine (HP:0100712)2.53146207
61Joint stiffness (HP:0001387)2.52077863
62Deformed sella turcica (HP:0002681)2.51593018
63Wrist flexion contracture (HP:0001239)2.51477826
64Recurrent bacterial skin infections (HP:0005406)2.51260140
65Orchitis (HP:0100796)2.51150255
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49955074
67Abnormality of polysaccharide metabolism (HP:0011012)2.49955074
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49955074
69Abnormality of macrophages (HP:0004311)2.48890813
70Abnormality of lateral ventricle (HP:0030047)2.47681178
71Abnormal platelet volume (HP:0011876)2.46100611
72Spontaneous abortion (HP:0005268)2.44030710
73Joint swelling (HP:0001386)2.43331683
74Obstructive lung disease (HP:0006536)2.41576127
75Chronic obstructive pulmonary disease (HP:0006510)2.41576127
76Arterial tortuosity (HP:0005116)2.40882000
77Bruising susceptibility (HP:0000978)2.39557340
78Hepatosplenomegaly (HP:0001433)2.37699269
79Increased mean platelet volume (HP:0011877)2.36571420
80Pulmonary embolism (HP:0002204)2.35396369
81Vascular tortuosity (HP:0004948)2.33587658
82Abnormality of the peritoneum (HP:0002585)2.30100126
83Portal hypertension (HP:0001409)2.29487328
84Autoimmune hemolytic anemia (HP:0001890)2.29415501
85Abnormality of iron homeostasis (HP:0011031)2.27716322
86Colitis (HP:0002583)2.26421423
87Interstitial pulmonary disease (HP:0006530)2.25845883
88Increased neuronal autofluorescent lipopigment (HP:0002074)2.24490530
89Aortic aneurysm (HP:0004942)2.23928865
90Gingival bleeding (HP:0000225)2.23319999
91Abnormality of the sella turcica (HP:0002679)2.23301822
92Tinnitus (HP:0000360)2.23195105
93Abnormality of the prostate (HP:0008775)2.22944531
94Abnormality of the thoracic spine (HP:0100711)2.19701387
95Toxemia of pregnancy (HP:0100603)2.18037491
96Abnormality of the vasculature of the conjunctiva (HP:0008054)2.17512563
97Increased cerebral lipofuscin (HP:0011813)2.15497362
98Facial diplegia (HP:0001349)2.15308268
99Chest pain (HP:0100749)2.14704231
100Petechiae (HP:0000967)2.11628042
101Protrusio acetabuli (HP:0003179)2.11505597
102Gastrointestinal infarctions (HP:0005244)2.09126068
103Decreased central vision (HP:0007663)2.08062354
104Arterial thrombosis (HP:0004420)2.07665555
105Abnormality of the hepatic vasculature (HP:0006707)2.06760587
106J-shaped sella turcica (HP:0002680)2.06079944
107Aortic dissection (HP:0002647)2.04853503
108Conjunctival telangiectasia (HP:0000524)2.04759783
109Abnormality of transition element cation homeostasis (HP:0011030)2.03692926
110Increased IgM level (HP:0003496)2.03539600
111Radial bowing (HP:0002986)2.03297530
112Abnormal auditory evoked potentials (HP:0006958)2.03250125
113Inflammation of the large intestine (HP:0002037)2.02535503
114Bronchomalacia (HP:0002780)2.00913196
115Periodontitis (HP:0000704)2.00333101
116Aneurysm (HP:0002617)1.99103704
117Encephalitis (HP:0002383)1.98683744
11811 pairs of ribs (HP:0000878)1.97249053
119Hyperthyroidism (HP:0000836)1.92787113
120Gastrointestinal inflammation (HP:0004386)1.91939014
121Broad face (HP:0000283)1.91729171
122Flat acetabular roof (HP:0003180)1.87313773
123Vertigo (HP:0002321)1.86829086
124Amyloidosis (HP:0011034)1.86523809
125Thrombophlebitis (HP:0004418)1.85550372
126Multifactorial inheritance (HP:0001426)1.84756786
127Thickened calvaria (HP:0002684)1.84595348
128Abnormality of the pericardium (HP:0001697)1.84317107
129Episodic fever (HP:0001954)1.79405475
130Upper limb muscle weakness (HP:0003484)1.70991954
131Xanthomatosis (HP:0000991)1.68918580
132Papillary thyroid carcinoma (HP:0002895)1.68264489
133Basal ganglia calcification (HP:0002135)1.66845562
134Increased serum ferritin (HP:0003281)1.65197126
135Leukocytosis (HP:0001974)1.64607614
136Generalized aminoaciduria (HP:0002909)1.63257313
137Amaurosis fugax (HP:0100576)1.62330280
138Nausea (HP:0002018)1.60176957
139Distal lower limb amyotrophy (HP:0008944)1.59917384
140Cerebral ischemia (HP:0002637)1.59704799
141Muscle fiber splitting (HP:0003555)1.58520980
142Panhypogammaglobulinemia (HP:0003139)1.57453972
143Muscle fibrillation (HP:0010546)1.56918749
144Ventricular fibrillation (HP:0001663)1.56237973
145Male infertility (HP:0003251)1.53648304
146Abnormality of binocular vision (HP:0011514)1.53237749
147Diplopia (HP:0000651)1.53237749
148Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.51578891
149Thyroid-stimulating hormone excess (HP:0002925)1.51303945
150Mucosal telangiectasiae (HP:0100579)1.50696013
151Vasculitis (HP:0002633)1.48526483
152Testicular neoplasm (HP:0010788)1.47389205
153Tongue fasciculations (HP:0001308)1.47222752
154Dysautonomia (HP:0002459)1.45021377
155Myocardial infarction (HP:0001658)1.44674000
156Microcytic anemia (HP:0001935)1.43731271
157Arthralgia (HP:0002829)1.42045089
158Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.38667326
159Meningitis (HP:0001287)1.30447177
160Granulocytopenia (HP:0001913)1.30275883
161Autoimmune thrombocytopenia (HP:0001973)1.29061000
162Recurrent viral infections (HP:0004429)1.28234124
163Eosinophilia (HP:0001880)1.28091173
164Exertional dyspnea (HP:0002875)1.25904711
165Hypertriglyceridemia (HP:0002155)1.25820196
166Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.25658938
167Recurrent fungal infections (HP:0002841)1.22142858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.39547940
2KDR4.93770364
3TGFBR23.56952019
4ERN13.55676652
5MST43.35029931
6RIPK13.31512162
7MST1R3.10446323
8TGFBR13.03079272
9EIF2AK12.42502286
10MAP4K12.30014413
11PIK3CG2.26494700
12EPHB12.24056245
13TAOK32.11798201
14TRIB32.03446390
15PKN21.97964378
16MUSK1.92869902
17EEF2K1.91074730
18BMPR21.76591624
19JAK31.69500178
20CAMK1D1.62574433
21BLK1.55477730
22TBK11.49942802
23EPHA31.49217982
24MAP2K31.49123220
25FES1.48543390
26ITK1.44910098
27FGR1.39235225
28MAP3K31.30573538
29STK31.29594914
30KIT1.27956804
31ADRBK21.27351881
32TEC1.23884117
33PTK61.19878657
34IKBKE1.19475924
35MAP3K141.18800941
36BTK1.11802611
37CSK1.06575977
38IRAK11.05957544
39MAPKAPK51.05413104
40JAK11.04061220
41DAPK21.02790777
42PRKCH1.02104920
43PIM20.98843633
44MET0.98716209
45MAP3K60.98170215
46DAPK30.97694605
47MAPKAPK30.96679409
48MAPK120.94225484
49CAMK1G0.93660529
50BMX0.93588453
51PAK10.93193160
52FGFR40.92583698
53SIK30.91897787
54TYK20.89824582
55JAK20.89398338
56HCK0.88000886
57MAP3K110.87814513
58IKBKB0.87400947
59LRRK20.87388480
60ZAP700.85261896
61ADRBK10.85126981
62LMTK20.84712253
63CDK90.82349364
64CDK80.82331118
65EPHB20.79740260
66MATK0.78047710
67CAMKK20.77135354
68STK100.76723428
69MAP3K50.76527991
70STK240.76422458
71STK40.74143912
72PTK2B0.72476445
73PRKG20.72189524
74ACVR1B0.72059703
75MARK30.71605938
76RPS6KA40.70626389
77NLK0.69973999
78TNIK0.69958548
79TESK20.66384863
80TRPM70.66047969
81PRKD10.65370680
82FGFR30.64481866
83LCK0.64060418
84CAMK40.63744754
85MAP3K10.62336124
86PDGFRB0.61218634
87PIM10.61213355
88TXK0.60151479
89IRAK40.58605150
90PRKD20.58153937
91IGF1R0.57768277
92TTN0.57704218
93MAPK40.56465354
94PLK20.54965927
95PDPK10.54176035
96NUAK10.53980413
97GRK10.53875257
98PRKACG0.52005397
99ERBB20.51968577
100TAOK20.50843602
101LYN0.50569901
102YES10.50041860
103MOS0.49075578
104TAOK10.49048551
105FYN0.48533632
106INSRR0.48186267
107EGFR0.46436774
108CHUK0.46105437
109SYK0.45833504
110PRKCQ0.44835846
111MAP2K10.44230879
112MAPK70.43672579
113PDK10.42716138
114PKN10.39606382
115PRKG10.39106464
116RET0.38780178
117RPS6KA60.38428748
118RPS6KB20.37782021
119PLK40.37479022
120MYLK0.37398131
121TNK20.37137994
122PRKCD0.35744735
123PAK40.35470853
124RPS6KA20.35225212
125MAP3K70.34888677
126IRAK20.34642967
127FLT30.33987639
128ARAF0.32897755
129PRKAA20.32585252
130BCKDK0.32018333
131CSF1R0.31824578
132SGK20.31557460
133TLK10.31228262
134GRK60.29545878
135HIPK20.29186062
136MAPKAPK20.29030390
137RAF10.28976704
138GRK50.28914787
139RIPK40.28805370
140FER0.28340294
141ILK0.27938468
142SRC0.27828137
143PTK20.27507273
144ABL10.27159206

Predicted pathways (KEGG)

RankGene SetZ-score
1* Staphylococcus aureus infection_Homo sapiens_hsa051505.13361997
2Complement and coagulation cascades_Homo sapiens_hsa046104.26281263
3Other glycan degradation_Homo sapiens_hsa005113.91980130
4* Malaria_Homo sapiens_hsa051443.29820351
5Pertussis_Homo sapiens_hsa051332.58666447
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.54431317
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.51107087
8Caffeine metabolism_Homo sapiens_hsa002322.46234572
9African trypanosomiasis_Homo sapiens_hsa051432.26883310
10Leishmaniasis_Homo sapiens_hsa051402.23228601
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.91875783
12Platelet activation_Homo sapiens_hsa046111.86588620
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79823161
14Vascular smooth muscle contraction_Homo sapiens_hsa042701.79343546
15Hematopoietic cell lineage_Homo sapiens_hsa046401.72392545
16Arachidonic acid metabolism_Homo sapiens_hsa005901.63311874
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.61787217
18TNF signaling pathway_Homo sapiens_hsa046681.61192430
19Gap junction_Homo sapiens_hsa045401.60862591
20Osteoclast differentiation_Homo sapiens_hsa043801.59310160
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.46787302
22Serotonergic synapse_Homo sapiens_hsa047261.44896049
23Asthma_Homo sapiens_hsa053101.43095798
24Systemic lupus erythematosus_Homo sapiens_hsa053221.36860316
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.32253700
26Long-term depression_Homo sapiens_hsa047301.30706439
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30131958
28Linoleic acid metabolism_Homo sapiens_hsa005911.26407155
29* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24585635
30Prion diseases_Homo sapiens_hsa050201.22690517
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18298520
32Legionellosis_Homo sapiens_hsa051341.18187438
33Pancreatic secretion_Homo sapiens_hsa049721.17746192
34B cell receptor signaling pathway_Homo sapiens_hsa046621.15435592
35Graft-versus-host disease_Homo sapiens_hsa053321.13894863
36Toxoplasmosis_Homo sapiens_hsa051451.13825762
37Allograft rejection_Homo sapiens_hsa053301.13256510
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12251762
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11149206
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10716541
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.10212132
42ECM-receptor interaction_Homo sapiens_hsa045121.08414586
43Glycerolipid metabolism_Homo sapiens_hsa005611.07155687
44Endocytosis_Homo sapiens_hsa041441.04924415
45Shigellosis_Homo sapiens_hsa051311.04872814
46Nitrogen metabolism_Homo sapiens_hsa009101.04765253
47Autoimmune thyroid disease_Homo sapiens_hsa053201.04413198
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03997561
49Amoebiasis_Homo sapiens_hsa051461.03747055
50Chemokine signaling pathway_Homo sapiens_hsa040621.03558638
51T cell receptor signaling pathway_Homo sapiens_hsa046601.02777851
52Measles_Homo sapiens_hsa051621.01512793
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.01483633
54ABC transporters_Homo sapiens_hsa020101.01157396
55Ovarian steroidogenesis_Homo sapiens_hsa049130.99705193
56Notch signaling pathway_Homo sapiens_hsa043300.98525233
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97359136
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97250152
59Alcoholism_Homo sapiens_hsa050340.96234210
60Acute myeloid leukemia_Homo sapiens_hsa052210.94121640
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93736687
62Focal adhesion_Homo sapiens_hsa045100.92676800
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92256525
64Choline metabolism in cancer_Homo sapiens_hsa052310.91426515
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90866161
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90853769
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88025085
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.86788469
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86033096
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85494668
71Herpes simplex infection_Homo sapiens_hsa051680.85270630
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85137211
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.83056068
74Collecting duct acid secretion_Homo sapiens_hsa049660.82650177
75Small cell lung cancer_Homo sapiens_hsa052220.81311200
76Apoptosis_Homo sapiens_hsa042100.80653687
77Chronic myeloid leukemia_Homo sapiens_hsa052200.79940672
78Salmonella infection_Homo sapiens_hsa051320.79600568
79Antigen processing and presentation_Homo sapiens_hsa046120.79390818
80Influenza A_Homo sapiens_hsa051640.78298728
81Rap1 signaling pathway_Homo sapiens_hsa040150.76887110
82Hepatitis C_Homo sapiens_hsa051600.76053551
83Renin secretion_Homo sapiens_hsa049240.75378039
84Lysosome_Homo sapiens_hsa041420.75135413
85Hepatitis B_Homo sapiens_hsa051610.73760421
86Circadian entrainment_Homo sapiens_hsa047130.72890471
87Olfactory transduction_Homo sapiens_hsa047400.72827786
88Renin-angiotensin system_Homo sapiens_hsa046140.71069521
89Bile secretion_Homo sapiens_hsa049760.70092699
90Proteoglycans in cancer_Homo sapiens_hsa052050.69241395
91Tuberculosis_Homo sapiens_hsa051520.69228017
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68828055
93Pancreatic cancer_Homo sapiens_hsa052120.68251270
94Fatty acid elongation_Homo sapiens_hsa000620.66982369
95VEGF signaling pathway_Homo sapiens_hsa043700.65991847
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.63571754
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63540382
98Rheumatoid arthritis_Homo sapiens_hsa053230.63260286
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62409344
100Dorso-ventral axis formation_Homo sapiens_hsa043200.61847233
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61572620
102Insulin resistance_Homo sapiens_hsa049310.61410895
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61104912
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60688347
105Dilated cardiomyopathy_Homo sapiens_hsa054140.60683215
106Non-small cell lung cancer_Homo sapiens_hsa052230.60079761
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58615621
108Pathways in cancer_Homo sapiens_hsa052000.58079224
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57999657
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57997583
111HTLV-I infection_Homo sapiens_hsa051660.57632769
112Primary immunodeficiency_Homo sapiens_hsa053400.57623911
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57573024
114Type I diabetes mellitus_Homo sapiens_hsa049400.54920769
115Calcium signaling pathway_Homo sapiens_hsa040200.53912745
116Viral carcinogenesis_Homo sapiens_hsa052030.52314188
117Sulfur metabolism_Homo sapiens_hsa009200.51523733
118Prolactin signaling pathway_Homo sapiens_hsa049170.50989406
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50507076
120Oxytocin signaling pathway_Homo sapiens_hsa049210.50343955
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50198131
122Salivary secretion_Homo sapiens_hsa049700.49480581
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49300628
124Vitamin digestion and absorption_Homo sapiens_hsa049770.48469244
125Adherens junction_Homo sapiens_hsa045200.47457673
126Histidine metabolism_Homo sapiens_hsa003400.47407970
127Gastric acid secretion_Homo sapiens_hsa049710.46603527
128Morphine addiction_Homo sapiens_hsa050320.46324388
129N-Glycan biosynthesis_Homo sapiens_hsa005100.45796024
130Galactose metabolism_Homo sapiens_hsa000520.44438586
131Renal cell carcinoma_Homo sapiens_hsa052110.43950955
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.43455880
133Fat digestion and absorption_Homo sapiens_hsa049750.43391419
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41092054
135HIF-1 signaling pathway_Homo sapiens_hsa040660.41008100
136Arginine biosynthesis_Homo sapiens_hsa002200.40805240
137Phagosome_Homo sapiens_hsa041450.37624286
138Ribosome_Homo sapiens_hsa030100.35895145
139PPAR signaling pathway_Homo sapiens_hsa033200.35796875
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34134445
141TGF-beta signaling pathway_Homo sapiens_hsa043500.32604435
142Viral myocarditis_Homo sapiens_hsa054160.32581813
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32296350
144Ras signaling pathway_Homo sapiens_hsa040140.29644208
145Starch and sucrose metabolism_Homo sapiens_hsa005000.24787628
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23914316

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