SELT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.09672396
2proteasome assembly (GO:0043248)4.63168553
3regulation of cellular amino acid metabolic process (GO:0006521)4.26015622
4signal peptide processing (GO:0006465)4.18828840
5cullin deneddylation (GO:0010388)4.11253261
6protein deneddylation (GO:0000338)3.90814846
7L-phenylalanine catabolic process (GO:0006559)3.82067590
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.82067590
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.78422676
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.72678007
11protein localization to endosome (GO:0036010)3.66723351
12alpha-linolenic acid metabolic process (GO:0036109)3.66381151
13L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.60836523
14lysine metabolic process (GO:0006553)3.57541274
15lysine catabolic process (GO:0006554)3.57541274
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.56892447
17L-phenylalanine metabolic process (GO:0006558)3.56892447
18cysteine metabolic process (GO:0006534)3.56542264
19respiratory chain complex IV assembly (GO:0008535)3.56476128
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.56203192
21DNA deamination (GO:0045006)3.52853811
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51223004
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47466168
24negative regulation of ligase activity (GO:0051352)3.47466168
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.42417410
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.42417410
27platelet dense granule organization (GO:0060155)3.40401182
28signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.38921175
29signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.38921175
30signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.38921175
31lactate metabolic process (GO:0006089)3.35501559
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.32788330
33water-soluble vitamin biosynthetic process (GO:0042364)3.31763773
34antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.21445609
35signal transduction involved in DNA integrity checkpoint (GO:0072401)3.20941642
36signal transduction involved in DNA damage checkpoint (GO:0072422)3.20941642
37ATP hydrolysis coupled proton transport (GO:0015991)3.19384757
38energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.19384757
39signal transduction involved in cell cycle checkpoint (GO:0072395)3.17296669
40eosinophil chemotaxis (GO:0048245)3.17294667
41dicarboxylic acid biosynthetic process (GO:0043650)3.16639064
42regulation of cellular amine metabolic process (GO:0033238)3.16116926
43ribosome assembly (GO:0042255)3.15205436
44positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14814956
45glutamate metabolic process (GO:0006536)3.14390039
46drug transmembrane transport (GO:0006855)3.11011428
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10516668
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09841893
49regulation of cholesterol homeostasis (GO:2000188)3.09821801
50Golgi transport vesicle coating (GO:0048200)3.08837996
51COPI coating of Golgi vesicle (GO:0048205)3.08837996
52branched-chain amino acid catabolic process (GO:0009083)3.04765987
53negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.04760288
54positive regulation of ligase activity (GO:0051351)3.03696416
55aromatic amino acid family catabolic process (GO:0009074)2.98314433
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98102956
57antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.97123377
58macroautophagy (GO:0016236)2.93633319
59amino acid salvage (GO:0043102)2.93250342
60L-methionine salvage (GO:0071267)2.93250342
61L-methionine biosynthetic process (GO:0071265)2.93250342
62activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.93099825
63sodium ion export (GO:0071436)2.90811385
64dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.88195427
65activation of protein kinase A activity (GO:0034199)2.87611542
66membrane budding (GO:0006900)2.87568025
67DNA double-strand break processing (GO:0000729)2.87411118
68fatty acid elongation (GO:0030497)2.84220869
69synaptic vesicle maturation (GO:0016188)2.81141675
70positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.80912769
71eosinophil migration (GO:0072677)2.80763832
72cytochrome complex assembly (GO:0017004)2.80420319
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79888019
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79888019
75cellular ketone body metabolic process (GO:0046950)2.78011907
76aspartate family amino acid catabolic process (GO:0009068)2.77374424
77sulfur amino acid catabolic process (GO:0000098)2.76106475
78protein carboxylation (GO:0018214)2.74939534
79peptidyl-glutamic acid carboxylation (GO:0017187)2.74939534
80cellular modified amino acid catabolic process (GO:0042219)2.74447821
81succinate metabolic process (GO:0006105)2.74183452
82triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.73503963
83homocysteine metabolic process (GO:0050667)2.72522794
84transferrin transport (GO:0033572)2.71547927
85short-chain fatty acid metabolic process (GO:0046459)2.71252502
86intracellular pH reduction (GO:0051452)2.70879129
872-oxoglutarate metabolic process (GO:0006103)2.70453269
884-hydroxyproline metabolic process (GO:0019471)2.69395781
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.69267264
90adenosine metabolic process (GO:0046085)2.69105771
91regulation of ubiquitin-protein transferase activity (GO:0051438)2.68726170
92negative regulation of protein ubiquitination (GO:0031397)2.68014148
93respiratory electron transport chain (GO:0022904)2.67618255
94glyoxylate metabolic process (GO:0046487)2.65579220
95peptidyl-histidine modification (GO:0018202)2.65460358
96electron transport chain (GO:0022900)2.64866932
97kynurenine metabolic process (GO:0070189)2.62858442
98anterograde synaptic vesicle transport (GO:0048490)2.62816737
99activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62739400
100bile acid biosynthetic process (GO:0006699)2.62652641
101cellular potassium ion homeostasis (GO:0030007)2.62052114
102nerve growth factor signaling pathway (GO:0038180)2.61697911
103regulation of ligase activity (GO:0051340)2.61423897
104fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.61374989
105drug catabolic process (GO:0042737)2.60764930
106intestinal epithelial cell development (GO:0060576)2.60392127
107negative regulation of execution phase of apoptosis (GO:1900118)2.59532625
108trivalent inorganic cation transport (GO:0072512)2.59436750
109ferric iron transport (GO:0015682)2.59436750
110mannosylation (GO:0097502)2.58924270
111dicarboxylic acid catabolic process (GO:0043649)2.58522843
112protein complex biogenesis (GO:0070271)2.57624268
113negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55651613
114serine family amino acid catabolic process (GO:0009071)2.55471301
115protein targeting to Golgi (GO:0000042)2.55317634
116negative regulation of fibrinolysis (GO:0051918)2.54907290
117tricarboxylic acid metabolic process (GO:0072350)2.54328335
118positive regulation of cell cycle arrest (GO:0071158)2.54145801
119positive regulation of actin filament depolymerization (GO:0030836)2.54026419
120phagosome maturation (GO:0090382)2.53717036
121protein maturation by protein folding (GO:0022417)2.52802524
122cytidine deamination (GO:0009972)2.52133918
123cytidine metabolic process (GO:0046087)2.52133918
124cytidine catabolic process (GO:0006216)2.52133918
125acetyl-CoA metabolic process (GO:0006084)2.52025219
126DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.51804919
127deoxyribose phosphate biosynthetic process (GO:0046385)2.50852427
1282-deoxyribonucleotide biosynthetic process (GO:0009265)2.50852427
129retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.49772813
130ER to Golgi vesicle-mediated transport (GO:0006888)2.48744460
131protein K11-linked ubiquitination (GO:0070979)2.47898405
132tricarboxylic acid cycle (GO:0006099)2.47783928
133negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.47776867
134C-terminal protein lipidation (GO:0006501)2.47149039
135layer formation in cerebral cortex (GO:0021819)2.46628561
136positive regulation of glycolytic process (GO:0045821)2.46564997
137COPII vesicle coating (GO:0048208)2.45955414
138urate metabolic process (GO:0046415)2.45766278
139ketone body metabolic process (GO:1902224)2.44743702
140positive regulation of nuclease activity (GO:0032075)2.44699179
141regulation of protein glycosylation (GO:0060049)2.44437253
142regulation of short-term neuronal synaptic plasticity (GO:0048172)2.44125050
143endoplasmic reticulum organization (GO:0007029)2.43705731
144vesicle coating (GO:0006901)2.43155475
145rRNA modification (GO:0000154)2.42977065
146regulation of clathrin-mediated endocytosis (GO:2000369)2.42720841
147potassium ion import (GO:0010107)2.42423716
148regulation of ARF protein signal transduction (GO:0032012)2.41265916
149urea metabolic process (GO:0019627)2.40926741
150urea cycle (GO:0000050)2.40926741
151bile acid metabolic process (GO:0008206)2.40888038
152establishment of protein localization to Golgi (GO:0072600)2.40127154
153purine-containing compound salvage (GO:0043101)2.39893199
154mitochondrial respiratory chain complex assembly (GO:0033108)2.38316470
155locomotory exploration behavior (GO:0035641)2.38135313
156deoxyribonucleotide biosynthetic process (GO:0009263)2.37817611
157transcription from mitochondrial promoter (GO:0006390)2.36693436
158regulation of fatty acid beta-oxidation (GO:0031998)2.36582171
159cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36497089
160exogenous drug catabolic process (GO:0042738)2.36303716
161membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.36229113
162high-density lipoprotein particle remodeling (GO:0034375)2.36200457
163positive regulation of fatty acid beta-oxidation (GO:0032000)2.36052468
164peptidyl-cysteine modification (GO:0018198)2.35405708
165acyl-CoA biosynthetic process (GO:0071616)2.34401932
166thioester biosynthetic process (GO:0035384)2.34401932
167pH reduction (GO:0045851)2.33456368
168maturation of 5.8S rRNA (GO:0000460)2.32964170
169tyrosine metabolic process (GO:0006570)2.32452291
170glycerol ether metabolic process (GO:0006662)2.32233203
171regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.32229451
172fatty-acyl-CoA biosynthetic process (GO:0046949)2.32170937
173preassembly of GPI anchor in ER membrane (GO:0016254)2.31714997
174regulation of synaptic vesicle exocytosis (GO:2000300)2.31689551
175complement activation, alternative pathway (GO:0006957)2.31318584
176cytoskeletal anchoring at plasma membrane (GO:0007016)2.31113432
177C-terminal protein amino acid modification (GO:0018410)2.30299089
178plasma lipoprotein particle clearance (GO:0034381)2.30187012
179reverse cholesterol transport (GO:0043691)2.28645886
180regulation of protein activation cascade (GO:2000257)2.28418434
181alpha-amino acid catabolic process (GO:1901606)2.27023450
182acylglycerol catabolic process (GO:0046464)2.26592180
183neutral lipid catabolic process (GO:0046461)2.26592180
184endoplasmic reticulum unfolded protein response (GO:0030968)2.25752873
185positive regulation of lipid catabolic process (GO:0050996)2.25193079
186vesicle transport along microtubule (GO:0047496)2.24674435
187amino-acid betaine metabolic process (GO:0006577)2.24440179
188drug transport (GO:0015893)2.24284632
189long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.23949129
190cellular amino acid catabolic process (GO:0009063)2.23813332
191ER-nucleus signaling pathway (GO:0006984)2.22262289
192fatty acid homeostasis (GO:0055089)2.21351588
193response to mercury ion (GO:0046689)2.20671083
194regulation of fibrinolysis (GO:0051917)2.20112875
195phosphate ion transport (GO:0006817)2.19378080
196regulation of triglyceride catabolic process (GO:0010896)2.18600293
197fatty acid transmembrane transport (GO:1902001)2.18374433
198regulation of cholesterol biosynthetic process (GO:0045540)2.18283503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.66419166
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11882187
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.68864164
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.57086234
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.51951166
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.27928366
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.06323120
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03396841
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85504649
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.65201530
11ELK1_19687146_ChIP-ChIP_HELA_Human2.64218442
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50629883
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.36406125
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30459141
15ZNF263_19887448_ChIP-Seq_K562_Human2.30169052
16CLOCK_20551151_ChIP-Seq_293T_Human2.26676992
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24193446
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.24025229
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22764784
20VDR_23849224_ChIP-Seq_CD4+_Human2.17144381
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15909968
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15266464
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13793493
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11162536
25TAF15_26573619_Chip-Seq_HEK293_Human2.03277799
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95453906
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95315456
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.88956172
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84986383
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82090148
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78872203
32VDR_22108803_ChIP-Seq_LS180_Human1.78672165
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75071616
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.74550196
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73303467
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.72117335
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.71225364
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66146980
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.65655563
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64804516
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.63692596
42EWS_26573619_Chip-Seq_HEK293_Human1.59167298
43IGF1R_20145208_ChIP-Seq_DFB_Human1.57838904
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57560660
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55115090
46P300_19829295_ChIP-Seq_ESCs_Human1.55074922
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.53749432
48GATA1_22025678_ChIP-Seq_K562_Human1.50557963
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50331828
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50310914
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.49307414
52FUS_26573619_Chip-Seq_HEK293_Human1.48788537
53HTT_18923047_ChIP-ChIP_STHdh_Human1.48490661
54FOXP3_21729870_ChIP-Seq_TREG_Human1.48019245
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.47282021
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.47128828
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46813732
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46458179
59DCP1A_22483619_ChIP-Seq_HELA_Human1.46446182
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44909059
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44717811
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.43819540
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38497149
64* ESR2_21235772_ChIP-Seq_MCF-7_Human1.37649115
65* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.33046004
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32984444
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.32762274
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32575449
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32495947
70GBX2_23144817_ChIP-Seq_PC3_Human1.31635379
71ER_23166858_ChIP-Seq_MCF-7_Human1.30270258
72SALL4_22934838_ChIP-ChIP_CD34+_Human1.27664393
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26776656
74DROSHA_22980978_ChIP-Seq_HELA_Human1.26530936
75KDM2B_26808549_Chip-Seq_K562_Human1.26248869
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25163517
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25163517
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.23929834
79TFEB_21752829_ChIP-Seq_HELA_Human1.23708972
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23226411
81P53_22387025_ChIP-Seq_ESCs_Mouse1.22810480
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22031433
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.21692842
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21635081
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.20397692
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20351506
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20284949
88GATA1_19941826_ChIP-Seq_K562_Human1.19912391
89RXR_22108803_ChIP-Seq_LS180_Human1.19445699
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.18717102
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18535654
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18164368
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.17957832
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17867421
95P300_18555785_Chip-Seq_ESCs_Mouse1.17771753
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17492537
97TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17027065
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16870018
99TP53_22573176_ChIP-Seq_HFKS_Human1.16646127
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16619429
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16318203
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.15738917
103* SOX2_19829295_ChIP-Seq_ESCs_Human1.15605338
104* NANOG_19829295_ChIP-Seq_ESCs_Human1.15605338
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.12981797
106CDX2_22108803_ChIP-Seq_LS180_Human1.11502487
107* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11321070
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10554955
109NMYC_18555785_Chip-Seq_ESCs_Mouse1.09767158
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.08832757
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08747927
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.08728305
113SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08171565
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08062681
115CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07709722
116ELK1_22589737_ChIP-Seq_MCF10A_Human1.07633159
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07245918
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07062844
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.06909245
120SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06763962
121CBP_20019798_ChIP-Seq_JUKART_Human1.06714493
122IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06714493
123AHR_22903824_ChIP-Seq_MCF-7_Human1.05846814
124WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05536772
125SOX2_21211035_ChIP-Seq_LN229_Gbm1.05386411
126* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05158330
127GATA3_26560356_Chip-Seq_TH2_Human1.03231529
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02893351
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02113061
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01743411
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01636995
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01626660
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01448489
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01423986
135SMAD4_21799915_ChIP-Seq_A2780_Human1.01274029
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01048809
137SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99980927
138KDM2B_26808549_Chip-Seq_DND41_Human0.99386984
139SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99346652
140EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99207610
141CTCF_18555785_Chip-Seq_ESCs_Mouse0.98910170
142IRF8_22096565_ChIP-ChIP_GC-B_Human0.98877264
143DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98705694
144PU1_27457419_Chip-Seq_LIVER_Mouse0.98301207
145ARNT_22903824_ChIP-Seq_MCF-7_Human0.98253302
146ZFX_18555785_Chip-Seq_ESCs_Mouse0.97192574
147KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96716564
148RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96509083
149EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96448178
150KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96301354
151ELF5_23300383_ChIP-Seq_T47D_Human0.95798757
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95203305
153TBX20_22080862_ChIP-Seq_HEART_Mouse0.94968083
154TBX20_22328084_ChIP-Seq_HEART_Mouse0.94968083
155ZNF274_21170338_ChIP-Seq_K562_Hela0.94949203
156REST_21632747_ChIP-Seq_MESCs_Mouse0.94144177
157FOXA1_25552417_ChIP-Seq_VCAP_Human0.93841056
158ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92046225
159ESR1_21235772_ChIP-Seq_MCF-7_Human0.91639650
160HNF4A_19822575_ChIP-Seq_HepG2_Human0.91269708
161CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91178124
162CREB1_26743006_Chip-Seq_LNCaP_Human0.90665730
163FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90139600
164GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89346518
165OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89274471
166SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89139579
167Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88759739
168* STAT3_23295773_ChIP-Seq_U87_Human0.88751084
169AR_21572438_ChIP-Seq_LNCaP_Human0.88408962
170TP63_23658742_ChIP-Seq_EP156T_Human0.88325217
171* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87878268
172WT1_19549856_ChIP-ChIP_CCG9911_Human0.87715467
173KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87713586
174MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87694491
175BCAT_22108803_ChIP-Seq_LS180_Human0.86843241
176SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86453715
177* SOX2_20726797_ChIP-Seq_SW620_Human0.85809410
178RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85379052
179* SMAD4_21741376_ChIP-Seq_HESCs_Human0.84171449
180CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83835369
181GATA2_19941826_ChIP-Seq_K562_Human0.83549999
182KDM2B_26808549_Chip-Seq_JURKAT_Human0.83506594
183RUNX1_27514584_Chip-Seq_MCF-7_Human0.83377362
184SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82512524
185SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81935266
186AR_19668381_ChIP-Seq_PC3_Human0.81817738
187NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81647832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.65154616
2MP0005360_urolithiasis4.22300264
3MP0005085_abnormal_gallbladder_physiolo3.39405611
4MP0005365_abnormal_bile_salt3.08717610
5MP0010234_abnormal_vibrissa_follicle3.01157722
6MP0003252_abnormal_bile_duct2.89714348
7MP0003195_calcinosis2.83444866
8MP0009780_abnormal_chondrocyte_physiolo2.75389063
9MP0008875_abnormal_xenobiotic_pharmacok2.58896506
10MP0003300_gastrointestinal_ulcer2.49971829
11MP0002909_abnormal_adrenal_gland2.49877105
12MP0004043_abnormal_pH_regulation2.40917438
13MP0002877_abnormal_melanocyte_morpholog2.37301314
14MP0003705_abnormal_hypodermis_morpholog2.31893999
15MP0005379_endocrine/exocrine_gland_phen2.30530572
16MP0003329_amyloid_beta_deposits2.17303576
17MP0005671_abnormal_response_to2.13206490
18MP0004859_abnormal_synaptic_plasticity2.13202569
19MP0005084_abnormal_gallbladder_morpholo2.12514361
20MP0010329_abnormal_lipoprotein_level2.11379546
21MP0010386_abnormal_urinary_bladder2.06828785
22MP0006036_abnormal_mitochondrial_physio2.06165278
23MP0009840_abnormal_foam_cell2.02084458
24MP0009046_muscle_twitch1.99215321
25MP0006054_spinal_hemorrhage1.98547147
26MP0005332_abnormal_amino_acid1.97870988
27MP0004130_abnormal_muscle_cell1.92202635
28MP0000013_abnormal_adipose_tissue1.91894283
29MP0009785_altered_susceptibility_to1.89504754
30MP0004270_analgesia1.89358408
31MP0001835_abnormal_antigen_presentation1.88646388
32MP0006082_CNS_inflammation1.88142521
33MP0000569_abnormal_digit_pigmentation1.83144388
34MP0008877_abnormal_DNA_methylation1.79417719
35MP0001666_abnormal_nutrient_absorption1.76830425
36MP0002148_abnormal_hypersensitivity_rea1.73740448
37MP0006035_abnormal_mitochondrial_morpho1.70516679
38MP0005464_abnormal_platelet_physiology1.69802797
39MP0004185_abnormal_adipocyte_glucose1.69619734
40MP0000604_amyloidosis1.69414180
41MP0002118_abnormal_lipid_homeostasis1.63091404
42MP0002163_abnormal_gland_morphology1.62271980
43MP0005083_abnormal_biliary_tract1.59803428
44MP0003690_abnormal_glial_cell1.59251822
45MP0005058_abnormal_lysosome_morphology1.58775685
46MP0003186_abnormal_redox_activity1.56319316
47MP0003880_abnormal_central_pattern1.54933093
48MP0003806_abnormal_nucleotide_metabolis1.51835324
49MP0002876_abnormal_thyroid_physiology1.50666872
50MP0003868_abnormal_feces_composition1.47667345
51MP0008961_abnormal_basal_metabolism1.47377968
52MP0009697_abnormal_copulation1.45211576
53MP0002736_abnormal_nociception_after1.45035770
54MP0000358_abnormal_cell_content/1.42222012
55MP0005645_abnormal_hypothalamus_physiol1.42171420
56MP0006072_abnormal_retinal_apoptosis1.41846106
57MP0009643_abnormal_urine_homeostasis1.40097977
58MP0000747_muscle_weakness1.39447687
59MP0002837_dystrophic_cardiac_calcinosis1.38900842
60MP0003786_premature_aging1.38845696
61MP0008872_abnormal_physiological_respon1.38784109
62MP0003191_abnormal_cellular_cholesterol1.37695008
63MP0002078_abnormal_glucose_homeostasis1.36661681
64MP0000609_abnormal_liver_physiology1.36206031
65MP0003303_peritoneal_inflammation1.35386433
66MP0004215_abnormal_myocardial_fiber1.34795009
67MP0001984_abnormal_olfaction1.33197404
68MP0001501_abnormal_sleep_pattern1.33002058
69MP0000685_abnormal_immune_system1.31223356
70MP0003283_abnormal_digestive_organ1.29057451
71MP0008058_abnormal_DNA_repair1.28161214
72MP0004885_abnormal_endolymph1.26826052
73MP0000003_abnormal_adipose_tissue1.26170894
74MP0001944_abnormal_pancreas_morphology1.25570222
75MP0003172_abnormal_lysosome_physiology1.23701107
76MP0002138_abnormal_hepatobiliary_system1.23265364
77MP0003635_abnormal_synaptic_transmissio1.22535646
78MP0001765_abnormal_ion_homeostasis1.21886440
79MP0003724_increased_susceptibility_to1.21677827
80MP0001905_abnormal_dopamine_level1.21211094
81MP0001529_abnormal_vocalization1.21115273
82MP0001853_heart_inflammation1.20836811
83MP0005000_abnormal_immune_tolerance1.19725833
84MP0005535_abnormal_body_temperature1.18831358
85MP0005584_abnormal_enzyme/coenzyme_acti1.18573021
86MP0001764_abnormal_homeostasis1.18209337
87MP0003787_abnormal_imprinting1.18093630
88MP0004019_abnormal_vitamin_homeostasis1.17641657
89MP0001756_abnormal_urination1.16953350
90MP0003045_fibrosis1.15936022
91MP0005666_abnormal_adipose_tissue1.15898326
92MP0000343_altered_response_to1.15541734
93MP0003011_delayed_dark_adaptation1.15368020
94MP0004858_abnormal_nervous_system1.15047582
95MP0002254_reproductive_system_inflammat1.14171543
96MP0009764_decreased_sensitivity_to1.12394165
97MP0001845_abnormal_inflammatory_respons1.12064486
98MP0005375_adipose_tissue_phenotype1.11926785
99MP0002896_abnormal_bone_mineralization1.11425826
100MP0008004_abnormal_stomach_pH1.09653711
101MP0005387_immune_system_phenotype1.08403564
102MP0001790_abnormal_immune_system1.08403564
103MP0000372_irregular_coat_pigmentation1.07691286
104MP0000647_abnormal_sebaceous_gland1.07146707
105MP0003633_abnormal_nervous_system1.07143197
106MP0002693_abnormal_pancreas_physiology1.06856434
107MP0005253_abnormal_eye_physiology1.06478525
108MP0002272_abnormal_nervous_system1.05234974
109MP0001968_abnormal_touch/_nociception1.03568803
110MP0005167_abnormal_blood-brain_barrier1.03233216
111MP0005310_abnormal_salivary_gland1.03049048
112MP0005319_abnormal_enzyme/_coenzyme1.02798009
113MP0003950_abnormal_plasma_membrane1.01568870
114MP0000920_abnormal_myelination1.00728713
115MP0002638_abnormal_pupillary_reflex1.00456940
116MP0002277_abnormal_respiratory_mucosa0.99296585
117MP0001919_abnormal_reproductive_system0.97419986
118MP0004036_abnormal_muscle_relaxation0.96966597
119MP0002928_abnormal_bile_duct0.95036146
120MP0005187_abnormal_penis_morphology0.94545681
121MP0000427_abnormal_hair_cycle0.94007927
122MP0005646_abnormal_pituitary_gland0.93968998
123MP0002168_other_aberrant_phenotype0.93749949
124MP0001299_abnormal_eye_distance/0.93699661
125MP0000465_gastrointestinal_hemorrhage0.93650456
126MP0002971_abnormal_brown_adipose0.92518582
127MP0008007_abnormal_cellular_replicative0.91569788
128MP0005165_increased_susceptibility_to0.91391006
129MP0003075_altered_response_to0.91332435
130MP0002090_abnormal_vision0.89254993
131MP0003634_abnormal_glial_cell0.88980242
132MP0005551_abnormal_eye_electrophysiolog0.88131925
133MP0004084_abnormal_cardiac_muscle0.87460180
134MP0002063_abnormal_learning/memory/cond0.86483744
135MP0002452_abnormal_antigen_presenting0.85918014
136MP0002102_abnormal_ear_morphology0.85893077
137MP0002723_abnormal_immune_serum0.85308703
138MP0000516_abnormal_urinary_system0.85127468
139MP0005367_renal/urinary_system_phenotyp0.85127468
140MP0002064_seizures0.85114126
141MP0003718_maternal_effect0.83297876
142MP0005623_abnormal_meninges_morphology0.83067456
143MP0001661_extended_life_span0.82151859
144MP0002734_abnormal_mechanical_nocicepti0.80623805
145MP0005220_abnormal_exocrine_pancreas0.80617834
146MP0002166_altered_tumor_susceptibility0.79821340
147MP0006276_abnormal_autonomic_nervous0.79157838
148MP0004957_abnormal_blastocyst_morpholog0.78253432
149MP0008873_increased_physiological_sensi0.76479081
150MP0001440_abnormal_grooming_behavior0.76326240
151MP0005166_decreased_susceptibility_to0.76269663
152MP0002006_tumorigenesis0.75788605
153MP0001727_abnormal_embryo_implantation0.75439100
154MP0010352_gastrointestinal_tract_polyps0.74646246
155MP0005636_abnormal_mineral_homeostasis0.73586630
156MP0003631_nervous_system_phenotype0.72601446
157MP0005334_abnormal_fat_pad0.72103626
158MP0002733_abnormal_thermal_nociception0.71955471
159MP0004264_abnormal_extraembryonic_tissu0.71764417
160MP0003953_abnormal_hormone_level0.68071418
161MP0002822_catalepsy0.67226802
162MP0002269_muscular_atrophy0.67103372
163MP0004087_abnormal_muscle_fiber0.66178277
164MP0004811_abnormal_neuron_physiology0.63819619
165MP0010678_abnormal_skin_adnexa0.63020121
166MP0002229_neurodegeneration0.62255890
167MP0009745_abnormal_behavioral_response0.61728289
168MP0000230_abnormal_systemic_arterial0.61212637
169MP0004145_abnormal_muscle_electrophysio0.60843258
170MP0008874_decreased_physiological_sensi0.60127604
171MP0002136_abnormal_kidney_physiology0.59904198
172MP0003566_abnormal_cell_adhesion0.58972323
173MP0000598_abnormal_liver_morphology0.57173611
174MP0003632_abnormal_nervous_system0.56692716

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)3.74856589
2Acute necrotizing encephalopathy (HP:0006965)3.72225260
3Progressive macrocephaly (HP:0004481)3.58201611
4Xanthomatosis (HP:0000991)3.36886105
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.35932778
6Hypoglycemic coma (HP:0001325)3.32239449
7Ketoacidosis (HP:0001993)3.31964083
8Abnormal mitochondria in muscle tissue (HP:0008316)3.31877093
9Acute encephalopathy (HP:0006846)3.29061235
10Intrahepatic cholestasis (HP:0001406)3.25585172
11Increased CSF lactate (HP:0002490)3.22247730
12Gout (HP:0001997)3.18721264
13Papilledema (HP:0001085)3.17166511
14Mitochondrial inheritance (HP:0001427)3.16745627
15Insidious onset (HP:0003587)3.11040874
16Termporal pattern (HP:0011008)3.11040874
17Methylmalonic acidemia (HP:0002912)3.08336316
18Abnormality of the anterior horn cell (HP:0006802)3.03209473
19Degeneration of anterior horn cells (HP:0002398)3.03209473
20Cerebral inclusion bodies (HP:0100314)3.03079380
21Type I transferrin isoform profile (HP:0003642)3.00832402
22Ketosis (HP:0001946)2.98020596
233-Methylglutaconic aciduria (HP:0003535)2.97688769
24Hypoglycemic seizures (HP:0002173)2.97297592
25Hyperinsulinemic hypoglycemia (HP:0000825)2.94666267
26Hyperglycinemia (HP:0002154)2.94563012
27Abnormal protein glycosylation (HP:0012346)2.85396952
28Abnormal glycosylation (HP:0012345)2.85396952
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.85396952
30Abnormal protein N-linked glycosylation (HP:0012347)2.85396952
31Hypokinesia (HP:0002375)2.85019833
32Hepatic necrosis (HP:0002605)2.78720696
33Methylmalonic aciduria (HP:0012120)2.78212748
34Neurofibrillary tangles (HP:0002185)2.72346560
35Abnormality of serine family amino acid metabolism (HP:0010894)2.71659983
36Abnormality of glycine metabolism (HP:0010895)2.71659983
37Hyperlipoproteinemia (HP:0010980)2.68669073
38Global brain atrophy (HP:0002283)2.67100567
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.64555998
40Increased hepatocellular lipid droplets (HP:0006565)2.63747195
41Hyperglycinuria (HP:0003108)2.63435880
42Abnormality of the common coagulation pathway (HP:0010990)2.62694070
43Hepatocellular necrosis (HP:0001404)2.61152393
44Hyperglycemia (HP:0003074)2.57489556
45Cerebral edema (HP:0002181)2.55949632
46Tongue fasciculations (HP:0001308)2.51750905
47Vacuolated lymphocytes (HP:0001922)2.47772460
48Back pain (HP:0003418)2.46897345
49Renal Fanconi syndrome (HP:0001994)2.44636096
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44270244
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44270244
52Neuroendocrine neoplasm (HP:0100634)2.43088716
53Lipid accumulation in hepatocytes (HP:0006561)2.42041811
54Hypoproteinemia (HP:0003075)2.41362186
55Visual hallucinations (HP:0002367)2.41244100
56Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.39459942
57Epidermoid cyst (HP:0200040)2.39291365
58Abnormality of vitamin B metabolism (HP:0004340)2.39152341
59Abnormality of glutamine family amino acid metabolism (HP:0010902)2.39029556
60Palpitations (HP:0001962)2.37037096
61Abnormality of purine metabolism (HP:0004352)2.36509675
62Abnormality of methionine metabolism (HP:0010901)2.35687561
63Supranuclear gaze palsy (HP:0000605)2.34717435
64Complement deficiency (HP:0004431)2.34058944
65Hypokalemic alkalosis (HP:0001949)2.33273771
66Hypothermia (HP:0002045)2.32665631
67Atrophy/Degeneration involving motor neurons (HP:0007373)2.32652738
68Increased circulating renin level (HP:0000848)2.32584272
69Reduced antithrombin III activity (HP:0001976)2.32015002
70Stomatitis (HP:0010280)2.30866113
71Lactic acidosis (HP:0003128)2.27232376
72Respiratory failure (HP:0002878)2.24753566
73Increased serum lactate (HP:0002151)2.23738386
74Skin nodule (HP:0200036)2.23563565
75Intention tremor (HP:0002080)2.23559583
76Increased serum pyruvate (HP:0003542)2.22759249
77Hypobetalipoproteinemia (HP:0003563)2.22688306
78Lethargy (HP:0001254)2.20691470
79Medial flaring of the eyebrow (HP:0010747)2.19925803
80Macroorchidism (HP:0000053)2.19215853
81Hyperammonemia (HP:0001987)2.18596080
82Abnormality of the intrinsic pathway (HP:0010989)2.18590295
83Action tremor (HP:0002345)2.18301835
84Mucopolysacchariduria (HP:0008155)2.18294447
85Urinary glycosaminoglycan excretion (HP:0003541)2.18294447
86Resting tremor (HP:0002322)2.15743566
87Sensorimotor neuropathy (HP:0007141)2.14069172
88Abnormality of the Achilles tendon (HP:0005109)2.13601310
89Conjunctival hamartoma (HP:0100780)2.09129134
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09008064
91Renal cortical cysts (HP:0000803)2.08953370
92CNS demyelination (HP:0007305)2.08528394
93Tetraparesis (HP:0002273)2.07012702
94Spastic diplegia (HP:0001264)2.06908243
95Muscle fibrillation (HP:0010546)2.06423123
96Cerebral hypomyelination (HP:0006808)2.05830414
97Generalized aminoaciduria (HP:0002909)2.04915313
98Increased CSF protein (HP:0002922)2.04764695
99Agitation (HP:0000713)2.02162281
100Symptomatic seizures (HP:0011145)2.01181574
101Hypoalphalipoproteinemia (HP:0003233)1.98704970
102Dysostosis multiplex (HP:0000943)1.97621154
103Abnormality of the vitamin B12 metabolism (HP:0004341)1.96781396
104Hypolipoproteinemia (HP:0010981)1.95918110
105Hypomagnesemia (HP:0002917)1.95047775
106Conjugated hyperbilirubinemia (HP:0002908)1.94936688
107Mitral stenosis (HP:0001718)1.94523086
108Metabolic alkalosis (HP:0200114)1.93067447
109Muscular hypotonia of the trunk (HP:0008936)1.92766268
110Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92291129
111Abnormality of glycolysis (HP:0004366)1.91818489
112Abnormality of polysaccharide metabolism (HP:0011012)1.90490404
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90490404
114Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90490404
115Abnormality of urine glucose concentration (HP:0011016)1.90206948
116Glycosuria (HP:0003076)1.90206948
117Proximal tubulopathy (HP:0000114)1.90007825
118Neoplasm of the adrenal gland (HP:0100631)1.89933510
119Diminished movement (HP:0002374)1.89678282
120Abnormality of alanine metabolism (HP:0010916)1.89555083
121Hyperalaninemia (HP:0003348)1.89555083
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89555083
123Exercise intolerance (HP:0003546)1.87632414
124Subacute progressive viral hepatitis (HP:0006572)1.87603593
125Abnormality of the corticospinal tract (HP:0002492)1.87427567
126Exertional dyspnea (HP:0002875)1.86989781
127Congenital primary aphakia (HP:0007707)1.86779461
128Chronic diarrhea (HP:0002028)1.85670841
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.85487967
130Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.85260695
131Postural tremor (HP:0002174)1.84488562
132Hepatocellular carcinoma (HP:0001402)1.84388240
133Achilles tendon contracture (HP:0001771)1.84049245
134Abnormality of liposaccharide metabolism (HP:0010968)1.83883266
135Abnormality of glycosphingolipid metabolism (HP:0004343)1.83883266
136Abnormality of glycolipid metabolism (HP:0010969)1.83883266
137Urinary urgency (HP:0000012)1.83724787
138Spastic tetraparesis (HP:0001285)1.82690734
139Aplasia/hypoplasia of the uterus (HP:0008684)1.82168560
140Hyperuricemia (HP:0002149)1.82059413
141Increased purine levels (HP:0004368)1.82059413
142Leukodystrophy (HP:0002415)1.80870154
143Late onset (HP:0003584)1.80834856
144Myocardial infarction (HP:0001658)1.80069413
145Exercise-induced muscle cramps (HP:0003710)1.80039862
146Pheochromocytoma (HP:0002666)1.79358475
147Irritability (HP:0000737)1.78228548
148Neoplasm of the peripheral nervous system (HP:0100007)1.78213388
149Fat malabsorption (HP:0002630)1.77646649
150Hyperactive renin-angiotensin system (HP:0000841)1.77211947
151Abnormality of vitamin metabolism (HP:0100508)1.76975731
152Abnormality of placental membranes (HP:0011409)1.76447974
153Amniotic constriction ring (HP:0009775)1.76447974
154Hyporeflexia of lower limbs (HP:0002600)1.76219941
155Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76203023
156Dicarboxylic aciduria (HP:0003215)1.76203023
157Gait imbalance (HP:0002141)1.75920785
158Insulin-resistant diabetes mellitus (HP:0000831)1.75101746
159Increased intramyocellular lipid droplets (HP:0012240)1.74979248
160Abnormality of endocrine pancreas physiology (HP:0012093)1.74357824
161Abnormality of the pancreatic islet cells (HP:0006476)1.74357824
162Restlessness (HP:0000711)1.74111212
163Nephrogenic diabetes insipidus (HP:0009806)1.73831987
164Protuberant abdomen (HP:0001538)1.73030127
165Alkalosis (HP:0001948)1.72702530
166Optic disc pallor (HP:0000543)1.72538143
167Abnormality of chloride homeostasis (HP:0011422)1.72249194
168Petechiae (HP:0000967)1.71964273
169Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71640385
170Degeneration of the lateral corticospinal tracts (HP:0002314)1.71640385
171Amyotrophic lateral sclerosis (HP:0007354)1.70770212
172Turricephaly (HP:0000262)1.70529463
173Thyroid carcinoma (HP:0002890)1.69641922
174Hypokalemia (HP:0002900)1.69183652
175Abnormality of renal resorption (HP:0011038)1.68254700
176Delusions (HP:0000746)1.68163352
177Abnormality of serum amino acid levels (HP:0003112)1.67689519
178Poor suck (HP:0002033)1.67636628
179Polyphagia (HP:0002591)1.67066711
180Lymphangioma (HP:0100764)1.66485239
181Retinal atrophy (HP:0001105)1.65482557
182Myoglobinuria (HP:0002913)1.65238038
183Hyperkalemia (HP:0002153)1.64553111
184Difficulty running (HP:0009046)1.63731195
185Focal segmental glomerulosclerosis (HP:0000097)1.63483751
186Neuronal loss in central nervous system (HP:0002529)1.63467055
187Bundle branch block (HP:0011710)1.63296954
188Impaired vibration sensation in the lower limbs (HP:0002166)1.63287820
189Impaired social interactions (HP:0000735)1.63094126
190Abnormal social behavior (HP:0012433)1.63094126
191Prolonged partial thromboplastin time (HP:0003645)1.62370558
192Glomerulosclerosis (HP:0000096)1.62207743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.97115518
2MAP3K123.93001604
3TRIB33.70323662
4EIF2AK33.65887716
5TRIM283.53734648
6MAP3K22.68176429
7EIF2AK12.64068774
8FRK2.56278181
9SCYL22.47861392
10BCR2.47009914
11PKN22.43224310
12MAP3K92.39541371
13KSR22.37152324
14ERBB32.15089538
15WNK42.05307111
16NTRK12.02710398
17TSSK61.89324185
18LATS11.85607474
19MAP4K21.77220840
20SIK11.76638631
21INSRR1.74310554
22RET1.69853807
23STK391.67757306
24TAOK31.67031099
25BUB11.59555488
26RIPK11.59158058
27MYLK1.58657439
28PDK21.57465828
29FGFR21.54435651
30PAK61.53948083
31STK38L1.53318058
32PAK31.53028835
33CAMKK11.51396931
34PTK61.50161194
35CAMK1G1.49627460
36TESK11.47500652
37MAP2K41.46461210
38BMPR21.45665993
39LIMK11.45414876
40NTRK31.44842488
41ALK1.42817642
42PDGFRA1.39606354
43MARK11.39074798
44PLK21.38782917
45SRPK11.38418211
46WNK11.35978850
47NUAK11.31348884
48MAP2K71.27122537
49CSNK1G31.26703914
50CAMKK21.25946387
51BMPR1B1.25639504
52SIK31.24849040
53PRKD31.23401066
54ADRBK21.23289726
55ERN11.21708092
56OXSR11.21355283
57MAP3K41.20052645
58EPHB11.18302918
59CAMK1D1.16664053
60ZAK1.14363668
61DAPK11.13806002
62PRKCH1.12951421
63PHKG11.10674608
64PHKG21.10674608
65PLK31.08640780
66PBK1.08169662
67VRK11.07657630
68PRKCE1.06637357
69FGFR41.05893123
70PNCK1.05509626
71PDPK11.04244472
72GRK11.04014638
73TTN1.01847850
74STK161.01722795
75FGFR31.00913594
76MAP3K10.99726617
77DAPK20.98667923
78MINK10.96453657
79MAPKAPK30.95133406
80PINK10.94858384
81PTK20.93551017
82JAK10.93464192
83CSNK1G20.91983038
84PDK40.90963654
85PDK30.90963654
86MET0.90722673
87PDK10.89157450
88HIPK20.88223994
89ACVR1B0.87811370
90FER0.87475599
91STK110.86660731
92WNK30.86358688
93JAK20.86045502
94SGK30.85900847
95TYRO30.85550430
96LMTK20.85330932
97NEK10.85231789
98LATS20.84055430
99MAP3K70.81648372
100TXK0.81028021
101BRSK20.77637865
102STK380.76776997
103LRRK20.74055975
104PRKAA10.74021631
105PRKD10.73166537
106SGK4940.73023757
107SGK2230.73023757
108CDK50.71693674
109BMX0.70193339
110MKNK20.69703307
111CASK0.69143059
112STK240.68058520
113MST1R0.67412657
114TEC0.66657971
115GSK3A0.66528299
116CDK60.64460080
117STK30.64227870
118PDGFRB0.63909388
119PAK40.63839726
120MAP2K10.63258414
121TAOK10.63179027
122GRK70.62896895
123MAP3K50.62273315
124KSR10.62174832
125EEF2K0.61812663
126SIK20.60451526
127BCKDK0.60372364
128ILK0.60045118
129TESK20.59693619
130CSNK1A1L0.58563502
131EPHA40.58160301
132GRK50.55731096
133IKBKB0.51884883
134PIM20.50016281
135CAMK2A0.49604310
136EGFR0.49506524
137ERBB40.48651643
138MARK30.48635909
139PRKACG0.47348440
140PRKAA20.46509853
141STK100.46320838
142FGFR10.44874207
143CAMK2G0.44179087
144EIF2AK20.43995674
145CSNK1G10.43677608
146EPHA30.42855564
147CAMK2D0.41980410
148YES10.41862649
149CAMK2B0.41365202
150IKBKE0.41111620
151FYN0.40908109
152MTOR0.40575191
153PRKCG0.40330876
154SGK10.39550771
155MAP3K140.38852585
156MAPK130.38424956
157TLK10.38368244
158IGF1R0.36337896
159MUSK0.36152181
160TNIK0.35890567
161RPS6KA40.35799984
162ARAF0.32220605
163PRKCQ0.32013048
164ABL10.31720710
165PAK10.29801593
166DAPK30.29118900
167CCNB10.28222859
168MKNK10.27733887
169CDK190.27211720
170ROCK10.27056922
171CSF1R0.27004924
172CSNK1A10.26775006

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.14191400
2Protein export_Homo sapiens_hsa030604.78936633
3Nitrogen metabolism_Homo sapiens_hsa009104.21574735
4Oxidative phosphorylation_Homo sapiens_hsa001903.08091410
5Collecting duct acid secretion_Homo sapiens_hsa049662.69705220
6Fatty acid elongation_Homo sapiens_hsa000622.64121138
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43477523
8Parkinsons disease_Homo sapiens_hsa050122.34262818
9Arginine biosynthesis_Homo sapiens_hsa002202.11324188
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.05777283
11Butanoate metabolism_Homo sapiens_hsa006501.98067664
12SNARE interactions in vesicular transport_Homo sapiens_hsa041301.92055026
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91388859
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.90324460
15Type I diabetes mellitus_Homo sapiens_hsa049401.85168077
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75416945
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70715918
18Vibrio cholerae infection_Homo sapiens_hsa051101.70557862
19Regulation of autophagy_Homo sapiens_hsa041401.69949925
20Bile secretion_Homo sapiens_hsa049761.68860776
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68570543
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67969789
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63415006
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59979565
25Fatty acid degradation_Homo sapiens_hsa000711.59805582
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59230769
27Rheumatoid arthritis_Homo sapiens_hsa053231.54830330
28Sulfur metabolism_Homo sapiens_hsa009201.51001023
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50068479
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49835704
31Tryptophan metabolism_Homo sapiens_hsa003801.47302807
32Alzheimers disease_Homo sapiens_hsa050101.45627418
33RNA polymerase_Homo sapiens_hsa030201.36807777
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31938254
35Propanoate metabolism_Homo sapiens_hsa006401.30670887
36Fatty acid metabolism_Homo sapiens_hsa012121.28821878
37Huntingtons disease_Homo sapiens_hsa050161.26379745
38Type II diabetes mellitus_Homo sapiens_hsa049301.25472664
39PPAR signaling pathway_Homo sapiens_hsa033201.22430512
40Insulin secretion_Homo sapiens_hsa049111.22427185
41N-Glycan biosynthesis_Homo sapiens_hsa005101.21093771
42Basal transcription factors_Homo sapiens_hsa030221.20936984
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20395929
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17694358
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16107663
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15873140
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12584940
48Olfactory transduction_Homo sapiens_hsa047401.11848128
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07654360
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06888738
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06289528
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05509740
53Legionellosis_Homo sapiens_hsa051341.03904934
54Complement and coagulation cascades_Homo sapiens_hsa046101.03866147
55Autoimmune thyroid disease_Homo sapiens_hsa053201.02371987
56Dorso-ventral axis formation_Homo sapiens_hsa043201.01049199
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00841054
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99573794
59Allograft rejection_Homo sapiens_hsa053300.98763545
60Sphingolipid metabolism_Homo sapiens_hsa006000.97577859
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95468635
62Long-term potentiation_Homo sapiens_hsa047200.95338178
63Glutathione metabolism_Homo sapiens_hsa004800.95111509
64Insulin resistance_Homo sapiens_hsa049310.94912018
65Folate biosynthesis_Homo sapiens_hsa007900.93682301
66Gastric acid secretion_Homo sapiens_hsa049710.91841459
67Thyroid hormone synthesis_Homo sapiens_hsa049180.89272652
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88722442
69Selenocompound metabolism_Homo sapiens_hsa004500.87934675
70GABAergic synapse_Homo sapiens_hsa047270.87204624
71Starch and sucrose metabolism_Homo sapiens_hsa005000.86243743
72Synaptic vesicle cycle_Homo sapiens_hsa047210.85616810
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85400343
74mTOR signaling pathway_Homo sapiens_hsa041500.84968031
75Non-homologous end-joining_Homo sapiens_hsa034500.84589437
76beta-Alanine metabolism_Homo sapiens_hsa004100.84281915
77Asthma_Homo sapiens_hsa053100.83770368
78Graft-versus-host disease_Homo sapiens_hsa053320.83759816
79Glucagon signaling pathway_Homo sapiens_hsa049220.83293841
80Pyruvate metabolism_Homo sapiens_hsa006200.82729111
81RNA degradation_Homo sapiens_hsa030180.82678409
82Estrogen signaling pathway_Homo sapiens_hsa049150.81777336
83Phagosome_Homo sapiens_hsa041450.81581722
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80871007
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.80692569
86Fatty acid biosynthesis_Homo sapiens_hsa000610.79421659
87Dopaminergic synapse_Homo sapiens_hsa047280.77866338
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76879358
89Peroxisome_Homo sapiens_hsa041460.76706283
90Histidine metabolism_Homo sapiens_hsa003400.76515621
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.76290507
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75810941
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74893103
94ABC transporters_Homo sapiens_hsa020100.74844233
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73700698
96Fat digestion and absorption_Homo sapiens_hsa049750.73615196
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71814987
98Shigellosis_Homo sapiens_hsa051310.70831708
99Renal cell carcinoma_Homo sapiens_hsa052110.70423569
100Circadian rhythm_Homo sapiens_hsa047100.69871704
101Carbon metabolism_Homo sapiens_hsa012000.69369972
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69014885
103Caffeine metabolism_Homo sapiens_hsa002320.68331882
104Renin secretion_Homo sapiens_hsa049240.67981822
105Glioma_Homo sapiens_hsa052140.67897092
106Cholinergic synapse_Homo sapiens_hsa047250.67890267
107Insulin signaling pathway_Homo sapiens_hsa049100.67368248
108Amphetamine addiction_Homo sapiens_hsa050310.66826876
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.66750285
110Prion diseases_Homo sapiens_hsa050200.66646685
111Cocaine addiction_Homo sapiens_hsa050300.66527281
112Metabolic pathways_Homo sapiens_hsa011000.66199231
113Antigen processing and presentation_Homo sapiens_hsa046120.65448022
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65027063
115Salivary secretion_Homo sapiens_hsa049700.64887915
116Pyrimidine metabolism_Homo sapiens_hsa002400.63083121
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63065176
118Lysosome_Homo sapiens_hsa041420.62840277
119Pancreatic secretion_Homo sapiens_hsa049720.62631600
120Circadian entrainment_Homo sapiens_hsa047130.62287849
121Glycerolipid metabolism_Homo sapiens_hsa005610.61801352
122AMPK signaling pathway_Homo sapiens_hsa041520.60671675
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58953193
124Vitamin B6 metabolism_Homo sapiens_hsa007500.58772654
125Primary immunodeficiency_Homo sapiens_hsa053400.58241580
126Purine metabolism_Homo sapiens_hsa002300.57466703
127Glutamatergic synapse_Homo sapiens_hsa047240.56897098
128Phenylalanine metabolism_Homo sapiens_hsa003600.55132279
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53307796
130Nucleotide excision repair_Homo sapiens_hsa034200.52346221
131GnRH signaling pathway_Homo sapiens_hsa049120.52037376
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51911038
133Mismatch repair_Homo sapiens_hsa034300.51670056
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51150733
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51091627
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50757044
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47596596
138Hematopoietic cell lineage_Homo sapiens_hsa046400.46547959
139Gap junction_Homo sapiens_hsa045400.45341216
140Lysine degradation_Homo sapiens_hsa003100.45095308
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44621858
142Morphine addiction_Homo sapiens_hsa050320.44418299
143Oxytocin signaling pathway_Homo sapiens_hsa049210.44087082
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43355369
145Biosynthesis of amino acids_Homo sapiens_hsa012300.42450211
146Phototransduction_Homo sapiens_hsa047440.41840875
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41319933
148Steroid biosynthesis_Homo sapiens_hsa001000.40745643
149cAMP signaling pathway_Homo sapiens_hsa040240.40460260
150Chemical carcinogenesis_Homo sapiens_hsa052040.40204875
151VEGF signaling pathway_Homo sapiens_hsa043700.39951294
152Staphylococcus aureus infection_Homo sapiens_hsa051500.39311917
153Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39275613
154Mineral absorption_Homo sapiens_hsa049780.39138536
155Endometrial cancer_Homo sapiens_hsa052130.39116835
156Amoebiasis_Homo sapiens_hsa051460.39032152
157Long-term depression_Homo sapiens_hsa047300.39014213
158Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38333055
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.37144643
160RNA transport_Homo sapiens_hsa030130.37015581
161Oocyte meiosis_Homo sapiens_hsa041140.34108527
162Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33719074
163Salmonella infection_Homo sapiens_hsa051320.33455384
164One carbon pool by folate_Homo sapiens_hsa006700.28623888
165Ether lipid metabolism_Homo sapiens_hsa005650.28582158
166Drug metabolism - other enzymes_Homo sapiens_hsa009830.28580937
167Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27771280
168Steroid hormone biosynthesis_Homo sapiens_hsa001400.24477431

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