SELV

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.53194037
2response to pheromone (GO:0019236)7.10913289
3axonemal dynein complex assembly (GO:0070286)6.68810142
4substrate-independent telencephalic tangential migration (GO:0021826)6.33282794
5substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.33282794
6epithelial cilium movement (GO:0003351)6.03274868
7N-terminal protein amino acid acetylation (GO:0006474)5.36283518
8regulation of gene silencing by RNA (GO:0060966)5.25253789
9regulation of posttranscriptional gene silencing (GO:0060147)5.25253789
10regulation of gene silencing by miRNA (GO:0060964)5.25253789
11piRNA metabolic process (GO:0034587)5.16256021
12sperm motility (GO:0030317)4.64617139
13nonmotile primary cilium assembly (GO:0035058)4.61949690
14cilium movement (GO:0003341)4.38534060
15negative regulation of protein oligomerization (GO:0032460)4.29263816
16DNA methylation involved in gamete generation (GO:0043046)4.16061147
17head development (GO:0060322)3.95919679
18chaperone-mediated protein transport (GO:0072321)3.95458762
19viral transcription (GO:0019083)3.91877239
20translational termination (GO:0006415)3.90105302
21paraxial mesoderm development (GO:0048339)3.65283168
22cerebral cortex neuron differentiation (GO:0021895)3.64503038
23indolalkylamine metabolic process (GO:0006586)3.54253692
24somatic hypermutation of immunoglobulin genes (GO:0016446)3.51114046
25somatic diversification of immune receptors via somatic mutation (GO:0002566)3.51114046
26cellular biogenic amine biosynthetic process (GO:0042401)3.50986998
27C4-dicarboxylate transport (GO:0015740)3.50662505
28L-serine metabolic process (GO:0006563)3.42631012
29telencephalon cell migration (GO:0022029)3.31970441
30amine biosynthetic process (GO:0009309)3.30577873
31ganglion development (GO:0061548)3.30048513
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.28094348
33forebrain cell migration (GO:0021885)3.26480168
34reproductive system development (GO:0061458)3.26290232
35protein import into peroxisome matrix (GO:0016558)3.23937255
36cotranslational protein targeting to membrane (GO:0006613)3.22197211
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.21135436
38protein targeting to ER (GO:0045047)3.18632120
39DNA strand renaturation (GO:0000733)3.17394432
40iron-sulfur cluster assembly (GO:0016226)3.16433585
41metallo-sulfur cluster assembly (GO:0031163)3.16433585
42spinal cord association neuron differentiation (GO:0021527)3.13816516
43translational elongation (GO:0006414)3.12770726
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.12762608
45cerebral cortex cell migration (GO:0021795)3.12598364
46isoprenoid biosynthetic process (GO:0008299)3.05078324
47regulation of telomerase activity (GO:0051972)3.04293203
48response to prostaglandin E (GO:0034695)3.03716606
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00110572
50cellular protein complex disassembly (GO:0043624)2.95439824
51protein localization to endoplasmic reticulum (GO:0070972)2.94927174
52negative regulation of translation, ncRNA-mediated (GO:0040033)2.92808769
53regulation of translation, ncRNA-mediated (GO:0045974)2.92808769
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.92808769
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.92706606
56cerebral cortex radially oriented cell migration (GO:0021799)2.90915127
57GTP biosynthetic process (GO:0006183)2.87760977
58opioid receptor signaling pathway (GO:0038003)2.86969253
59single strand break repair (GO:0000012)2.85726435
60viral life cycle (GO:0019058)2.85238317
61rRNA methylation (GO:0031167)2.84756681
62DNA methylation (GO:0006306)2.83538311
63DNA alkylation (GO:0006305)2.83538311
64protein localization to peroxisome (GO:0072662)2.83084986
65protein targeting to peroxisome (GO:0006625)2.83084986
66establishment of protein localization to peroxisome (GO:0072663)2.83084986
67ATP synthesis coupled proton transport (GO:0015986)2.80650847
68energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80650847
69neuron remodeling (GO:0016322)2.79803796
70translational initiation (GO:0006413)2.79232314
71rRNA modification (GO:0000154)2.77621109
72positive regulation of dendritic spine morphogenesis (GO:0061003)2.77578253
73left/right axis specification (GO:0070986)2.76896110
74lateral ventricle development (GO:0021670)2.76407432
75presynaptic membrane assembly (GO:0097105)2.74095550
76intracellular protein transmembrane import (GO:0044743)2.73799879
77male meiosis (GO:0007140)2.73397486
78protein complex disassembly (GO:0043241)2.71163655
79DNA ligation (GO:0006266)2.70625045
80spermatid development (GO:0007286)2.70165045
81UTP biosynthetic process (GO:0006228)2.68249436
82N-terminal protein amino acid modification (GO:0031365)2.67737924
83serine family amino acid catabolic process (GO:0009071)2.66459792
84macromolecular complex disassembly (GO:0032984)2.65309186
85postsynaptic membrane organization (GO:0001941)2.64474545
86ribosomal small subunit biogenesis (GO:0042274)2.58621013
87pre-miRNA processing (GO:0031054)2.58186750
88glycine metabolic process (GO:0006544)2.55858056
89ribosomal large subunit biogenesis (GO:0042273)2.52496100
90somite development (GO:0061053)2.49861475
91intraciliary transport (GO:0042073)2.49364881
92DNA methylation or demethylation (GO:0044728)2.49007793
93serine family amino acid biosynthetic process (GO:0009070)2.47699158
94positive regulation of T cell apoptotic process (GO:0070234)2.46844770
95acrosome reaction (GO:0007340)2.46515879
96cilium assembly (GO:0042384)2.43827279
97meiotic chromosome segregation (GO:0045132)2.42799051
98response to folic acid (GO:0051593)2.42542130
99protein targeting to membrane (GO:0006612)2.40870879
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.1949867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.49264646
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.01781452
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.74833304
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40858898
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36402996
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32216955
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31438845
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.28184147
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.27790261
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25582557
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.17226622
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.17142515
13SOX2_16153702_ChIP-ChIP_HESCs_Human2.02826652
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87687155
15MYC_18555785_ChIP-Seq_MESCs_Mouse1.87202347
16GABP_17652178_ChIP-ChIP_JURKAT_Human1.84399280
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.82737104
18RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79268629
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79006818
20YY1_21170310_ChIP-Seq_MESCs_Mouse1.77384184
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73423508
22ZNF274_21170338_ChIP-Seq_K562_Hela1.69498657
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68432097
24FUS_26573619_Chip-Seq_HEK293_Human1.68321290
25REST_21632747_ChIP-Seq_MESCs_Mouse1.61344223
26NANOG_16153702_ChIP-ChIP_HESCs_Human1.59282151
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57479646
28SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54239921
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53933090
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51039575
31SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.50932810
32FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.49188840
33CTCF_27219007_Chip-Seq_Bcells_Human1.45850597
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42263518
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42263518
36TTF2_22483619_ChIP-Seq_HELA_Human1.41162947
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38562013
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36648704
39ELK1_19687146_ChIP-ChIP_HELA_Human1.36142334
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35980106
41AR_21572438_ChIP-Seq_LNCaP_Human1.34487119
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34454933
43P300_19829295_ChIP-Seq_ESCs_Human1.31925531
44GBX2_23144817_ChIP-Seq_PC3_Human1.27811581
45XRN2_22483619_ChIP-Seq_HELA_Human1.27731290
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25782295
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23463148
48* ERA_21632823_ChIP-Seq_H3396_Human1.22362548
49FOXP3_21729870_ChIP-Seq_TREG_Human1.22297323
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17671346
51TAF2_19829295_ChIP-Seq_ESCs_Human1.17031400
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16699421
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16489412
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16402371
55NANOG_20526341_ChIP-Seq_ESCs_Human1.16246236
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16185927
57E2F1_17053090_ChIP-ChIP_MCF-7_Human1.15523805
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15180489
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14698537
60RNF2_27304074_Chip-Seq_NSC_Mouse1.14077021
61P53_21459846_ChIP-Seq_SAOS-2_Human1.12866970
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12196905
63SMAD3_21741376_ChIP-Seq_ESCs_Human1.10722415
64MYC_18940864_ChIP-ChIP_HL60_Human1.10715006
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.09819617
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08675026
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.08497315
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.07996321
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.07073397
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05838292
71EWS_26573619_Chip-Seq_HEK293_Human1.03465276
72* FOXP1_21924763_ChIP-Seq_HESCs_Human1.02375847
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02058107
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.01786071
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01648650
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98817567
77VDR_22108803_ChIP-Seq_LS180_Human0.98420122
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98228114
79SMAD4_21741376_ChIP-Seq_EPCs_Human0.97258762
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96952734
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95538971
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95014095
83EZH2_27304074_Chip-Seq_ESCs_Mouse0.93861504
84GABP_19822575_ChIP-Seq_HepG2_Human0.93216220
85OCT4_19829295_ChIP-Seq_ESCs_Human0.91175698
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91108585
87EZH2_27294783_Chip-Seq_ESCs_Mouse0.90970125
88TET1_21451524_ChIP-Seq_MESCs_Mouse0.90867243
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89097339
90FOXH1_21741376_ChIP-Seq_ESCs_Human0.88703175
91HOXB7_26014856_ChIP-Seq_BT474_Human0.88513368
92SOX2_18692474_ChIP-Seq_MESCs_Mouse0.88315564
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87807777
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.87390121
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85706624
96BCAT_22108803_ChIP-Seq_LS180_Human0.85678976
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85646929
98SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.84661420
99CTCF_20526341_ChIP-Seq_ESCs_Human0.84544994
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83342381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.85939982
2MP0003878_abnormal_ear_physiology5.85939982
3MP0004885_abnormal_endolymph3.63899431
4MP0002102_abnormal_ear_morphology3.22521045
5MP0002254_reproductive_system_inflammat2.68902498
6MP0004133_heterotaxia2.57152960
7MP0002653_abnormal_ependyma_morphology2.47635216
8MP0006292_abnormal_olfactory_placode2.45371122
9MP0001984_abnormal_olfaction2.39922820
10MP0003119_abnormal_digestive_system2.35142520
11MP0003136_yellow_coat_color2.34343700
12MP0005423_abnormal_somatic_nervous2.28234008
13MP0002822_catalepsy2.27539458
14MP0005645_abnormal_hypothalamus_physiol2.16172639
15MP0001529_abnormal_vocalization2.09567546
16MP0003879_abnormal_hair_cell1.99554732
17MP0003880_abnormal_central_pattern1.99552980
18MP0001293_anophthalmia1.99250315
19MP0005410_abnormal_fertilization1.85301393
20MP0003890_abnormal_embryonic-extraembry1.78771219
21MP0002938_white_spotting1.77100540
22MP0003122_maternal_imprinting1.74694128
23MP0006276_abnormal_autonomic_nervous1.71305181
24MP0005379_endocrine/exocrine_gland_phen1.70016853
25MP0000778_abnormal_nervous_system1.68363182
26MP0005394_taste/olfaction_phenotype1.68346219
27MP0005499_abnormal_olfactory_system1.68346219
28MP0002837_dystrophic_cardiac_calcinosis1.53322499
29MP0008789_abnormal_olfactory_epithelium1.48892311
30MP0004742_abnormal_vestibular_system1.44103020
31MP0009379_abnormal_foot_pigmentation1.42597197
32MP0001486_abnormal_startle_reflex1.40821520
33MP0005365_abnormal_bile_salt1.40220291
34MP0003646_muscle_fatigue1.39076065
35MP0003942_abnormal_urinary_system1.34251591
36MP0002163_abnormal_gland_morphology1.32336229
37MP0003567_abnormal_fetal_cardiomyocyte1.29746913
38MP0002557_abnormal_social/conspecific_i1.28814074
39MP0009384_cardiac_valve_regurgitation1.25899597
40MP0005551_abnormal_eye_electrophysiolog1.25852157
41MP0002233_abnormal_nose_morphology1.25739527
42MP0003861_abnormal_nervous_system1.25341384
43MP0010030_abnormal_orbit_morphology1.25131046
44MP0006035_abnormal_mitochondrial_morpho1.24489272
45MP0003693_abnormal_embryo_hatching1.23808531
46MP0003698_abnormal_male_reproductive1.18722976
47MP0001348_abnormal_lacrimal_gland1.15557334
48MP0003937_abnormal_limbs/digits/tail_de1.15316171
49MP0002272_abnormal_nervous_system1.14021601
50MP0006072_abnormal_retinal_apoptosis1.13353134
51MP0003121_genomic_imprinting1.11562835
52MP0000462_abnormal_digestive_system1.07557931
53MP0000049_abnormal_middle_ear1.06250089
54MP0000026_abnormal_inner_ear1.05899569
55MP0008932_abnormal_embryonic_tissue1.05467864
56MP0002752_abnormal_somatic_nervous1.00535120
57MP0002734_abnormal_mechanical_nocicepti0.98994178
58MP0002210_abnormal_sex_determination0.98655991
59MP0003123_paternal_imprinting0.98053770
60MP0008058_abnormal_DNA_repair0.96117612
61MP0004270_analgesia0.95482992
62MP0004142_abnormal_muscle_tone0.94080911
63MP0002132_abnormal_respiratory_system0.93984209
64MP0000372_irregular_coat_pigmentation0.93422581
65MP0001963_abnormal_hearing_physiology0.92725325
66MP0001986_abnormal_taste_sensitivity0.92361892
67MP0005171_absent_coat_pigmentation0.92140456
68MP0005253_abnormal_eye_physiology0.91776330
69MP0008995_early_reproductive_senescence0.91635983
70MP0009672_abnormal_birth_weight0.90096222
71MP0001929_abnormal_gametogenesis0.89449833
72MP0008877_abnormal_DNA_methylation0.87015758
73MP0002184_abnormal_innervation0.85888700
74MP0000631_abnormal_neuroendocrine_gland0.85063021
75MP0002733_abnormal_thermal_nociception0.84560575
76MP0001970_abnormal_pain_threshold0.84363629
77MP0001485_abnormal_pinna_reflex0.83807895
78MP0002751_abnormal_autonomic_nervous0.82064293
79MP0001440_abnormal_grooming_behavior0.80562591
80MP0001145_abnormal_male_reproductive0.80355401
81MP0002160_abnormal_reproductive_system0.79846163
82MP0001346_abnormal_lacrimal_gland0.79642174
83MP0002152_abnormal_brain_morphology0.78905499
84MP0010094_abnormal_chromosome_stability0.76924140
85MP0003635_abnormal_synaptic_transmissio0.76854328
86MP0003938_abnormal_ear_development0.76153060
87MP0002697_abnormal_eye_size0.76148122
88MP0005195_abnormal_posterior_eye0.75357510
89MP0001968_abnormal_touch/_nociception0.75062441
90MP0002882_abnormal_neuron_morphology0.74668711
91MP0009745_abnormal_behavioral_response0.74479176
92MP0002735_abnormal_chemical_nociception0.74304997
93MP0000653_abnormal_sex_gland0.72554070
94MP0003718_maternal_effect0.72402665
95MP0005391_vision/eye_phenotype0.72330998
96MP0008872_abnormal_physiological_respon0.71975004
97MP0004957_abnormal_blastocyst_morpholog0.71303598
98MP0002084_abnormal_developmental_patter0.70462788
99MP0000955_abnormal_spinal_cord0.70211278
100MP0002572_abnormal_emotion/affect_behav0.69785158

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.70213675
2Absent/shortened dynein arms (HP:0200106)9.70213675
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.02125261
4Chronic bronchitis (HP:0004469)6.41519809
5Abnormal respiratory epithelium morphology (HP:0012253)5.60039574
6Abnormal respiratory motile cilium morphology (HP:0005938)5.60039574
7Abnormal ciliary motility (HP:0012262)5.49628287
8Turricephaly (HP:0000262)5.40829371
9Papilledema (HP:0001085)4.34730370
10Abnormal respiratory motile cilium physiology (HP:0012261)4.30713731
11Nasal polyposis (HP:0100582)4.14199544
12Rhinitis (HP:0012384)3.94992328
13Reticulocytopenia (HP:0001896)3.61873859
14Hypoplasia of the thymus (HP:0000778)3.38943967
15Abnormality of the nasal mucosa (HP:0000433)3.26777655
16Asplenia (HP:0001746)3.24650280
17Colon cancer (HP:0003003)3.20368703
18Aplasia/Hypoplasia of the spleen (HP:0010451)3.15225685
19Poor suck (HP:0002033)3.05562749
20Supernumerary spleens (HP:0009799)3.04551014
21Molar tooth sign on MRI (HP:0002419)3.04338681
22Abnormality of midbrain morphology (HP:0002418)3.04338681
23Polyphagia (HP:0002591)2.89412416
24Anomalous pulmonary venous return (HP:0010772)2.74433903
25Progressive cerebellar ataxia (HP:0002073)2.71449329
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.67510929
27Double outlet right ventricle (HP:0001719)2.63299799
28Congenital malformation of the right heart (HP:0011723)2.63299799
29Recurrent sinusitis (HP:0011108)2.59000235
30Septo-optic dysplasia (HP:0100842)2.56065526
31Polyuria (HP:0000103)2.48595078
32Peritonitis (HP:0002586)2.46887428
33Impulsivity (HP:0100710)2.44517168
34Hyperaldosteronism (HP:0000859)2.43457090
35Hypokalemic alkalosis (HP:0001949)2.41399384
36Nephronophthisis (HP:0000090)2.39445164
37Abnormality of the pulmonary veins (HP:0011718)2.29912462
38Elevated erythrocyte sedimentation rate (HP:0003565)2.18305629
39Osteomalacia (HP:0002749)2.15622417
40Abnormality of cells of the erythroid lineage (HP:0012130)2.13958414
41Acute necrotizing encephalopathy (HP:0006965)2.12186454
42Abnormal number of erythroid precursors (HP:0012131)2.10891327
43Increased circulating renin level (HP:0000848)2.10428510
44Pendular nystagmus (HP:0012043)2.07267770
45Polydipsia (HP:0001959)2.06481427
46Abnormal drinking behavior (HP:0030082)2.06481427
47Brushfield spots (HP:0001088)2.05998689
48Hypoplastic pelvis (HP:0008839)2.03803534
49Cortical dysplasia (HP:0002539)2.03749343
50Abnormality of the renal medulla (HP:0100957)2.02887177
51Abnormal urine output (HP:0012590)2.02091934
52Abnormality of the labia minora (HP:0012880)1.98085949
53Thyroid-stimulating hormone excess (HP:0002925)1.93788002
54Congenital stationary night blindness (HP:0007642)1.92155403
55Optic disc pallor (HP:0000543)1.89932757
56Bronchitis (HP:0012387)1.87840576
57Abnormal lung lobation (HP:0002101)1.85001431
58Bony spicule pigmentary retinopathy (HP:0007737)1.83758546
59Failure to thrive in infancy (HP:0001531)1.82846668
60Trigonocephaly (HP:0000243)1.82190845
61Hypokalemia (HP:0002900)1.81849029
62Abnormality of renal excretion (HP:0011036)1.81511480
63Chronic hepatic failure (HP:0100626)1.81244490
64Abnormal mitochondria in muscle tissue (HP:0008316)1.80552133
65Lissencephaly (HP:0001339)1.78883553
66Metabolic alkalosis (HP:0200114)1.78584433
67Acute encephalopathy (HP:0006846)1.77702176
68Enlarged kidneys (HP:0000105)1.76470720
69Bronchiectasis (HP:0002110)1.76462851
70Absent septum pellucidum (HP:0001331)1.74189765
71Transposition of the great arteries (HP:0001669)1.73088170
72Abnormal connection of the cardiac segments (HP:0011545)1.73088170
73Abnormal ventriculo-arterial connection (HP:0011563)1.73088170
74Abnormality of the aortic arch (HP:0012303)1.72519897
75Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70236813
76Renal salt wasting (HP:0000127)1.68492754
77Abnormal eating behavior (HP:0100738)1.67897207
78Amelogenesis imperfecta (HP:0000705)1.66288308
79Hepatoblastoma (HP:0002884)1.63976376
80Medial flaring of the eyebrow (HP:0010747)1.61276281
81Severe visual impairment (HP:0001141)1.61030108
82Clitoromegaly (HP:0000057)1.60796431
83Chromsome breakage (HP:0040012)1.58633329
84Truncus arteriosus (HP:0001660)1.53501175
85Macrocytic anemia (HP:0001972)1.53422757
86Long foot (HP:0001833)1.52925426
87Progressive macrocephaly (HP:0004481)1.52910083
88Mitochondrial inheritance (HP:0001427)1.52155140
89Increased CSF lactate (HP:0002490)1.51367378
90Pancreatic fibrosis (HP:0100732)1.51259633
91Rib fusion (HP:0000902)1.50250301
92Abnormality of chloride homeostasis (HP:0011422)1.50136173
93Proximal tubulopathy (HP:0000114)1.49340482
94Ectopic kidney (HP:0000086)1.49134557
95Palpebral edema (HP:0100540)1.48507969
96Abnormality of renal resorption (HP:0011038)1.48047459
97Maternal diabetes (HP:0009800)1.47255351
98Calcaneovalgus deformity (HP:0001848)1.46743850
99Myokymia (HP:0002411)1.46313464
100Epiphyseal stippling (HP:0010655)1.43077559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.96956633
2TAF13.89632997
3CAMK1D3.25922219
4VRK23.22395406
5CDC73.20985645
6NUAK12.96621944
7WNK42.68059623
8CDK192.60218027
9CAMK1G2.42048505
10OXSR12.15241330
11ZAK2.14956460
12DYRK22.14828762
13TTK2.12942811
14SMG12.10330224
15ACVR1B2.09046769
16NME22.04614089
17STK392.00305754
18NEK11.98205712
19WNK31.95486207
20CASK1.85102365
21STK38L1.84325294
22PINK11.81977530
23NEK21.73732232
24MAP4K21.63186291
25TLK11.45187660
26VRK11.45000044
27CSNK1G21.39912765
28EPHA41.39193940
29TNIK1.37229960
30BRD41.29569982
31CAMK11.24683026
32PASK1.22924249
33BCKDK1.20270762
34STK381.16131769
35PLK41.10410842
36CSNK1A1L1.10075687
37MAP3K41.04999475
38PLK31.03461391
39STK31.01630433
40MAP2K71.01403987
41CSNK1G30.99727407
42CSNK1G10.97586402
43BRAF0.85282051
44PRKD30.84697231
45PLK10.84672930
46MKNK10.83860636
47STK160.83841898
48CHEK20.80675879
49MKNK20.80040970
50RPS6KA40.79733378
51NME10.77870144
52BMPR1B0.77176373
53MAPK150.74349323
54GRK50.72722923
55FGFR20.70634717
56AURKA0.69802036
57PDK20.65116908
58RPS6KA20.62862308
59PAK30.60223907
60LATS20.59903554
61SRPK10.59014822
62NLK0.57951678
63PBK0.56786666
64ADRBK20.54133165
65PRKCE0.53884042
66DAPK30.53542132
67GRK10.53044328
68PRKAA20.52299722
69INSRR0.51254873
70CDK30.50425058
71STK110.50316900
72MAP3K100.50267162
73ARAF0.49504183
74NTRK30.48396809
75ADRBK10.46257122
76FRK0.46236769
77BRSK20.46211871
78MARK10.45905145
79DYRK1A0.45256482
80DYRK30.44634372
81UHMK10.44414985
82IRAK10.43706159
83PLK20.42645413
84TGFBR10.42624271
85PRKCG0.41861896
86CSNK1E0.40900770
87MINK10.40631289
88TYRO30.40609329
89EIF2AK30.39970084
90CDK20.37547764
91STK40.37507168
92MAPK130.37391457
93PRKACA0.37262976
94MAPKAPK50.37018628
95ATM0.36728408
96CHEK10.35873195
97RPS6KA50.34338580
98BCR0.33553502
99TIE10.33262398
100BMX0.32983668

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.84755076
2Oxidative phosphorylation_Homo sapiens_hsa001903.33487877
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.23498521
4Phototransduction_Homo sapiens_hsa047442.98008708
5Parkinsons disease_Homo sapiens_hsa050122.74068893
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35578852
7Huntingtons disease_Homo sapiens_hsa050162.21075782
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.11356381
9Homologous recombination_Homo sapiens_hsa034402.10941746
10Basal cell carcinoma_Homo sapiens_hsa052172.00895058
11Fanconi anemia pathway_Homo sapiens_hsa034601.95932226
12Selenocompound metabolism_Homo sapiens_hsa004501.85046899
13Alzheimers disease_Homo sapiens_hsa050101.79160182
14Cardiac muscle contraction_Homo sapiens_hsa042601.77065132
15Nicotine addiction_Homo sapiens_hsa050331.76722165
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58025331
17Peroxisome_Homo sapiens_hsa041461.56509922
18Protein export_Homo sapiens_hsa030601.55588703
19Tryptophan metabolism_Homo sapiens_hsa003801.54987486
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53875718
21Basal transcription factors_Homo sapiens_hsa030221.53698313
22Mismatch repair_Homo sapiens_hsa034301.49717088
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42895728
24RNA transport_Homo sapiens_hsa030131.39443147
25Taste transduction_Homo sapiens_hsa047421.38912276
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37109145
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.33479512
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31900289
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30772261
30Pyruvate metabolism_Homo sapiens_hsa006201.30715064
31Collecting duct acid secretion_Homo sapiens_hsa049661.23498880
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21313076
33Olfactory transduction_Homo sapiens_hsa047401.21275613
34Biosynthesis of amino acids_Homo sapiens_hsa012301.19376385
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17963920
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17104912
37RNA polymerase_Homo sapiens_hsa030201.12688664
38Morphine addiction_Homo sapiens_hsa050321.11856638
39RNA degradation_Homo sapiens_hsa030181.03557132
40mRNA surveillance pathway_Homo sapiens_hsa030151.02848460
41Wnt signaling pathway_Homo sapiens_hsa043101.01496909
42Axon guidance_Homo sapiens_hsa043601.01496196
43Hedgehog signaling pathway_Homo sapiens_hsa043400.98774295
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97500950
45GABAergic synapse_Homo sapiens_hsa047270.94947501
46Steroid biosynthesis_Homo sapiens_hsa001000.94327807
47Base excision repair_Homo sapiens_hsa034100.92957302
48DNA replication_Homo sapiens_hsa030300.92038750
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88267774
50Glutamatergic synapse_Homo sapiens_hsa047240.86624531
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84080072
52Inositol phosphate metabolism_Homo sapiens_hsa005620.81610475
53Metabolic pathways_Homo sapiens_hsa011000.81175164
54One carbon pool by folate_Homo sapiens_hsa006700.80706603
55Melanogenesis_Homo sapiens_hsa049160.77322685
56Nucleotide excision repair_Homo sapiens_hsa034200.73856992
57Vitamin digestion and absorption_Homo sapiens_hsa049770.73417070
58Hippo signaling pathway_Homo sapiens_hsa043900.71540229
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68942959
60Arginine biosynthesis_Homo sapiens_hsa002200.67652934
61Purine metabolism_Homo sapiens_hsa002300.65708518
62Arginine and proline metabolism_Homo sapiens_hsa003300.64524859
63Oocyte meiosis_Homo sapiens_hsa041140.63365035
64Carbon metabolism_Homo sapiens_hsa012000.62796408
65Proteasome_Homo sapiens_hsa030500.62582941
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62124512
67Serotonergic synapse_Homo sapiens_hsa047260.61684044
68Spliceosome_Homo sapiens_hsa030400.60453575
69Vibrio cholerae infection_Homo sapiens_hsa051100.58074664
70Insulin secretion_Homo sapiens_hsa049110.57703571
71Pyrimidine metabolism_Homo sapiens_hsa002400.55057820
72Linoleic acid metabolism_Homo sapiens_hsa005910.54105428
73Thyroid cancer_Homo sapiens_hsa052160.53767190
74Nitrogen metabolism_Homo sapiens_hsa009100.53095242
75Sulfur relay system_Homo sapiens_hsa041220.52871129
76Circadian entrainment_Homo sapiens_hsa047130.52638185
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51881183
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50539346
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49852707
80Regulation of autophagy_Homo sapiens_hsa041400.49515267
81Non-homologous end-joining_Homo sapiens_hsa034500.49022289
82Ether lipid metabolism_Homo sapiens_hsa005650.48259068
83Thyroid hormone synthesis_Homo sapiens_hsa049180.47904635
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47557600
85Folate biosynthesis_Homo sapiens_hsa007900.45554884
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44528053
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.43287150
88Cell cycle_Homo sapiens_hsa041100.41021324
89Synaptic vesicle cycle_Homo sapiens_hsa047210.40664359
90Arachidonic acid metabolism_Homo sapiens_hsa005900.39954862
91Propanoate metabolism_Homo sapiens_hsa006400.38541719
92Calcium signaling pathway_Homo sapiens_hsa040200.38490189
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37723561
94Notch signaling pathway_Homo sapiens_hsa043300.36030783
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35877767
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35446061
97Glutathione metabolism_Homo sapiens_hsa004800.34491957
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.34427733
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34101394
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33429864

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