SEMA3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of extracellular ligand from receptor (GO:0035581)5.24956306
2chondrocyte proliferation (GO:0035988)5.17383363
3metanephric mesenchyme development (GO:0072075)4.30548682
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.08084302
5establishment of integrated proviral latency (GO:0075713)4.04535308
6DNA double-strand break processing (GO:0000729)4.02891352
7cerebral cortex radially oriented cell migration (GO:0021799)3.97831572
8bone trabecula formation (GO:0060346)3.88829214
9kidney mesenchyme development (GO:0072074)3.88092476
10collagen fibril organization (GO:0030199)3.84327092
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.68752966
12extracellular negative regulation of signal transduction (GO:1900116)3.68626118
13extracellular regulation of signal transduction (GO:1900115)3.68626118
14* axon extension involved in axon guidance (GO:0048846)3.62975241
15* neuron projection extension involved in neuron projection guidance (GO:1902284)3.62975241
16response to X-ray (GO:0010165)3.58571019
17chromatin remodeling at centromere (GO:0031055)3.57645053
18mesenchymal-epithelial cell signaling (GO:0060638)3.53549746
19craniofacial suture morphogenesis (GO:0097094)3.51802382
20negative regulation of fatty acid transport (GO:2000192)3.48916709
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.46756402
22regulation of mitotic spindle checkpoint (GO:1903504)3.46756402
23CENP-A containing nucleosome assembly (GO:0034080)3.38238359
24positive regulation of cardiac muscle cell differentiation (GO:2000727)3.34678366
25replication fork processing (GO:0031297)3.32892332
26histone exchange (GO:0043486)3.30751051
27cullin deneddylation (GO:0010388)3.25316946
28pyrimidine nucleobase catabolic process (GO:0006208)3.24857113
29embryonic cranial skeleton morphogenesis (GO:0048701)3.21634343
30limb bud formation (GO:0060174)3.18474836
31negative regulation of DNA-dependent DNA replication (GO:2000104)3.17982190
32female gonad development (GO:0008585)3.13467640
33interleukin-6-mediated signaling pathway (GO:0070102)3.10551042
34protein localization to kinetochore (GO:0034501)3.07936243
35retinal ganglion cell axon guidance (GO:0031290)3.05703356
36protein heterotrimerization (GO:0070208)3.05606814
37hippo signaling (GO:0035329)3.03225168
38establishment of viral latency (GO:0019043)3.02387079
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.01636284
40spindle checkpoint (GO:0031577)3.01039699
41paraxial mesoderm development (GO:0048339)2.99169046
42mitotic sister chromatid cohesion (GO:0007064)2.99039317
43response to pheromone (GO:0019236)2.98560878
44* negative chemotaxis (GO:0050919)2.96091841
45G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.95789609
46middle ear morphogenesis (GO:0042474)2.95504706
47cranial suture morphogenesis (GO:0060363)2.92862491
48artery development (GO:0060840)2.91955056
49telomere maintenance via telomerase (GO:0007004)2.91085364
50positive regulation of mesenchymal cell proliferation (GO:0002053)2.90197122
51negative regulation of mitotic sister chromatid separation (GO:2000816)2.89937889
52negative regulation of sister chromatid segregation (GO:0033046)2.89937889
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89937889
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89937889
55negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89937889
56regulation of mesenchymal cell proliferation (GO:0010464)2.89681441
57mitotic metaphase plate congression (GO:0007080)2.88295892
58negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87605232
59negative regulation of translation, ncRNA-mediated (GO:0040033)2.87605232
60regulation of translation, ncRNA-mediated (GO:0045974)2.87605232
61mitotic spindle checkpoint (GO:0071174)2.86649102
62negative regulation of stem cell proliferation (GO:2000647)2.86380203
63DNA replication-independent nucleosome organization (GO:0034724)2.86349162
64DNA replication-independent nucleosome assembly (GO:0006336)2.86349162
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85803692
66protein deneddylation (GO:0000338)2.85705566
67IMP biosynthetic process (GO:0006188)2.85269147
68negative regulation of chromosome segregation (GO:0051985)2.84800844
69regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82418972
70presynaptic membrane assembly (GO:0097105)2.82313802
71central nervous system projection neuron axonogenesis (GO:0021952)2.81324793
72replicative senescence (GO:0090399)2.81214603
73regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80699103
74regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80699103
75DNA strand renaturation (GO:0000733)2.79922002
76DNA replication-dependent nucleosome organization (GO:0034723)2.78611089
77DNA replication-dependent nucleosome assembly (GO:0006335)2.78611089
78anterior/posterior axis specification, embryo (GO:0008595)2.78061072
79maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75335405
80insulin-like growth factor receptor signaling pathway (GO:0048009)2.73489546
81negative regulation of chondrocyte differentiation (GO:0032331)2.71908275
82double-strand break repair via nonhomologous end joining (GO:0006303)2.71684740
83non-recombinational repair (GO:0000726)2.71684740
84mesenchymal cell differentiation (GO:0048762)2.71190921
85metaphase plate congression (GO:0051310)2.70784018
86smooth muscle tissue development (GO:0048745)2.69639478
87mesenchymal cell differentiation involved in kidney development (GO:0072161)2.67694835
88mesenchymal cell differentiation involved in renal system development (GO:2001012)2.67694835
89chondrocyte development (GO:0002063)2.66661961
90positive regulation of osteoblast differentiation (GO:0045669)2.66508101
91regulation of sister chromatid segregation (GO:0033045)2.66259925
92regulation of mitotic sister chromatid separation (GO:0010965)2.66259925
93regulation of mitotic sister chromatid segregation (GO:0033047)2.66259925
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.65156514
95camera-type eye morphogenesis (GO:0048593)2.63687674
96cell adhesion mediated by integrin (GO:0033627)2.63511398
97cardiac epithelial to mesenchymal transition (GO:0060317)2.63236141
98postsynaptic membrane organization (GO:0001941)2.62408776
99endocardial cushion development (GO:0003197)2.62225100
100regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.61525714
101lymphangiogenesis (GO:0001946)2.61366037
102L-serine metabolic process (GO:0006563)2.60355933
103regulation of centriole replication (GO:0046599)2.60252992
104outer ear morphogenesis (GO:0042473)2.58454080
105DNA replication checkpoint (GO:0000076)2.57306638
106ventricular cardiac muscle cell development (GO:0055015)2.56849769
107DNA ligation (GO:0006266)2.55763248
108cranial nerve morphogenesis (GO:0021602)2.55154567
109mitotic spindle assembly checkpoint (GO:0007094)2.54526041
110endodermal cell differentiation (GO:0035987)2.53220674
111regulation of non-canonical Wnt signaling pathway (GO:2000050)2.52269694
112cell proliferation involved in metanephros development (GO:0072203)2.52197829
113regulation of secondary heart field cardioblast proliferation (GO:0003266)2.51974499
114regulation of cardioblast proliferation (GO:0003264)2.51974499
115negative regulation of DNA recombination (GO:0045910)2.51845263
116regulation of heart morphogenesis (GO:2000826)2.51444276
117cartilage morphogenesis (GO:0060536)2.51229689
118plasma membrane repair (GO:0001778)2.50283717
119spindle assembly checkpoint (GO:0071173)2.50216130
120dermatan sulfate biosynthetic process (GO:0030208)2.49951715
121negative regulation of keratinocyte proliferation (GO:0010839)2.49705116
122lymph vessel development (GO:0001945)2.48989894
123specification of organ identity (GO:0010092)2.48239503
124epithelial to mesenchymal transition (GO:0001837)2.47971308
125Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.47016722
126regulation of DNA endoreduplication (GO:0032875)2.46742571
127establishment of nucleus localization (GO:0040023)2.46183461
128regulation of chromosome segregation (GO:0051983)2.45842785
129nucleobase catabolic process (GO:0046113)2.45634732
130ATP-dependent chromatin remodeling (GO:0043044)2.45326594
131pre-miRNA processing (GO:0031054)2.44877763
132purine nucleobase biosynthetic process (GO:0009113)2.44715216
133* ganglion development (GO:0061548)2.44225671
134DNA damage response, detection of DNA damage (GO:0042769)2.44184977
135IMP metabolic process (GO:0046040)2.43934529
136dorsal/ventral axis specification (GO:0009950)2.43163265
137presynaptic membrane organization (GO:0097090)2.42927122
138sister chromatid segregation (GO:0000819)2.42743001
139neural crest cell development (GO:0014032)2.42517127
140regulation of stem cell proliferation (GO:0072091)2.42271475
141cell differentiation involved in kidney development (GO:0061005)2.42134265
142regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.42111219
143generation of neurons (GO:0048699)2.41256601
144fibroblast migration (GO:0010761)2.41177336
145cochlea morphogenesis (GO:0090103)2.39981845
146cell proliferation involved in kidney development (GO:0072111)2.39916313
147RNA-dependent DNA replication (GO:0006278)2.39733386
148nuclear pore organization (GO:0006999)2.39694650
149positive regulation of stem cell proliferation (GO:2000648)2.38896204
150myoblast fusion (GO:0007520)2.37997580
151cell migration involved in sprouting angiogenesis (GO:0002042)2.37843976
152regulation of establishment of planar polarity (GO:0090175)2.37693991
153kidney morphogenesis (GO:0060993)2.37598368
154body morphogenesis (GO:0010171)2.35704444
155* axonal fasciculation (GO:0007413)2.35527444
156vocalization behavior (GO:0071625)2.35512707
157nuclear pore complex assembly (GO:0051292)2.35169224
158* axon extension (GO:0048675)2.35040228
159DNA catabolic process, exonucleolytic (GO:0000738)2.34764238
160negative regulation of DNA repair (GO:0045738)2.34453276
161atrial septum morphogenesis (GO:0060413)2.33841248
162histone H2A acetylation (GO:0043968)2.33711086
163negative regulation of embryonic development (GO:0045992)2.33644911
164regulation of cardiac muscle cell differentiation (GO:2000725)2.33120276
165positive regulation of smoothened signaling pathway (GO:0045880)2.33060081
166endocrine hormone secretion (GO:0060986)2.32949822
167embryonic forelimb morphogenesis (GO:0035115)2.32775686
168regulation of helicase activity (GO:0051095)2.32201268
169heterochromatin organization (GO:0070828)2.32199301
170cell proliferation in forebrain (GO:0021846)2.31733364
171central nervous system neuron axonogenesis (GO:0021955)2.30965268
172mesenchymal cell proliferation (GO:0010463)2.30827041
173regulation of keratinocyte proliferation (GO:0010837)2.30456480
174inner ear receptor cell development (GO:0060119)2.29966096
175cellular response to vitamin D (GO:0071305)2.29932979
176regulation of telomere maintenance (GO:0032204)2.28800378
177positive regulation of fibroblast migration (GO:0010763)2.28559474
178lateral sprouting from an epithelium (GO:0060601)2.28200334
179mitotic sister chromatid segregation (GO:0000070)2.28028144
180regulation of skeletal muscle contraction (GO:0014819)2.27737321
181proteasome assembly (GO:0043248)2.27635519
182mesonephric tubule development (GO:0072164)2.27494384
183negative regulation of mitosis (GO:0045839)2.27445941
184mesodermal cell differentiation (GO:0048333)2.27193362
185convergent extension (GO:0060026)2.26817068
186establishment of chromosome localization (GO:0051303)2.26796679
187* neuron recognition (GO:0008038)2.26486171
188attachment of spindle microtubules to kinetochore (GO:0008608)2.25969938
189bone remodeling (GO:0046849)2.25784217
190ureteric bud development (GO:0001657)2.25044913
191palate development (GO:0060021)2.24963332
192negative regulation of fibroblast apoptotic process (GO:2000270)2.24163920
193kinetochore organization (GO:0051383)2.22433235

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.61484725
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.55027456
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.48619157
4E2F7_22180533_ChIP-Seq_HELA_Human3.10531177
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.80862749
6* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.76769771
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.66923854
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.60785866
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.52079645
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45333829
11EZH2_22144423_ChIP-Seq_EOC_Human2.32146544
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.31060263
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29225255
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21257938
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21257938
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.19893670
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19625906
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.19162037
19* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17897294
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11924028
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.10895765
22* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06121186
23* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.05250491
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.03587427
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01793533
26JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01516892
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01452315
28* TP53_18474530_ChIP-ChIP_U2OS_Human2.00365590
29ZNF274_21170338_ChIP-Seq_K562_Hela1.99756926
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98079939
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.97052330
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96849902
33* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91139004
34FUS_26573619_Chip-Seq_HEK293_Human1.90593829
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82820857
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.82647023
37* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.80901473
38* PIAS1_25552417_ChIP-Seq_VCAP_Human1.80801006
39* P300_19829295_ChIP-Seq_ESCs_Human1.76567344
40VDR_22108803_ChIP-Seq_LS180_Human1.74467735
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72444009
42ELK1_19687146_ChIP-ChIP_HELA_Human1.70657423
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70260159
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69428274
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67049132
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67049132
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67040384
48SMAD4_21799915_ChIP-Seq_A2780_Human1.65494320
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.65135209
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64917253
51* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64326747
52TAF15_26573619_Chip-Seq_HEK293_Human1.64310016
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63018008
54EWS_26573619_Chip-Seq_HEK293_Human1.62703076
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59311015
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.58718686
57TP53_16413492_ChIP-PET_HCT116_Human1.58490962
58AR_21909140_ChIP-Seq_LNCAP_Human1.57097110
59CJUN_26792858_Chip-Seq_BT549_Human1.56545207
60* NANOG_16153702_ChIP-ChIP_HESCs_Human1.54495011
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52992655
62* SOX2_16153702_ChIP-ChIP_HESCs_Human1.52829390
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.52091867
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50202174
65* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49808125
66AR_21572438_ChIP-Seq_LNCaP_Human1.49510612
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48312425
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.48102270
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.47317730
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46917496
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44795774
72* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44145420
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.41724122
74* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41347199
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41073132
76BRD4_25478319_ChIP-Seq_HGPS_Human1.40702198
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40316224
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36965830
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35365606
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.32465114
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.29223724
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28924453
83* RNF2_27304074_Chip-Seq_NSC_Mouse1.28759370
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.28282887
85* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28250241
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28153030
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.25795184
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25772270
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.24722513
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23394801
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23248291
92RXR_22108803_ChIP-Seq_LS180_Human1.23049775
93AHR_22903824_ChIP-Seq_MCF-7_Human1.22911590
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22769032
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22424839
96TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22371510
97TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21889879
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21711584
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21156486
100* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20113965
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.19681790
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.19665990
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19088335
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.18934706
105SOX9_26525672_Chip-Seq_HEART_Mouse1.17705115
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.17558019
107* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17020799
108JUN_21703547_ChIP-Seq_K562_Human1.17016474
109IGF1R_20145208_ChIP-Seq_DFB_Human1.16316997
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15592319
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.15272577
112* SOX2_21211035_ChIP-Seq_LN229_Gbm1.15160515
113* AR_25329375_ChIP-Seq_VCAP_Human1.14441848
114* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13363753
115RUNX2_22187159_ChIP-Seq_PCA_Human1.13184698
116STAT3_23295773_ChIP-Seq_U87_Human1.13054921
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.11704764
118* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11108434
119* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11012152
120SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08852146
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08627265
122RING1B_27294783_Chip-Seq_NPCs_Mouse1.08521368
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08444476
124CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08075175
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07822441
126* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07759256
127SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06989482
128* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06656779
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06277185
130PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05504300
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05168319
132POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04736696
133P53_22387025_ChIP-Seq_ESCs_Mouse1.04698796
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04456426
135* TCF4_23295773_ChIP-Seq_U87_Human1.03882232
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03678453
137* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03488521
138BCAT_22108803_ChIP-Seq_LS180_Human1.02262193
139RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01068491
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00570053
141AR_19668381_ChIP-Seq_PC3_Human0.99664804
142CMYC_18555785_Chip-Seq_ESCs_Mouse0.99471925
143NFE2_27457419_Chip-Seq_LIVER_Mouse0.99374579
144RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98221505
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98016871
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96385393
147CBP_20019798_ChIP-Seq_JUKART_Human0.96385393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.42434456
2MP0005503_abnormal_tendon_morphology3.85091010
3MP0010030_abnormal_orbit_morphology3.75762114
4MP0005275_abnormal_skin_tensile2.72979563
5MP0003385_abnormal_body_wall2.70985626
6MP0002102_abnormal_ear_morphology2.50804415
7MP0009053_abnormal_anal_canal2.47968666
8MP0005171_absent_coat_pigmentation2.47755630
9MP0008058_abnormal_DNA_repair2.37542156
10MP0000566_synostosis2.31524638
11MP0009250_abnormal_appendicular_skeleto2.30963884
12MP0003122_maternal_imprinting2.28470428
13MP0005623_abnormal_meninges_morphology2.26154946
14MP0003890_abnormal_embryonic-extraembry2.18510371
15MP0001529_abnormal_vocalization2.15927961
16MP0010094_abnormal_chromosome_stability2.06266948
17MP0003942_abnormal_urinary_system2.04838815
18MP0008789_abnormal_olfactory_epithelium1.98787566
19MP0008932_abnormal_embryonic_tissue1.98432648
20MP0003755_abnormal_palate_morphology1.94813534
21MP0001188_hyperpigmentation1.86341424
22MP0005248_abnormal_Harderian_gland1.84519182
23MP0004272_abnormal_basement_membrane1.82198557
24MP0003119_abnormal_digestive_system1.80927168
25MP0003941_abnormal_skin_development1.78433080
26MP0003705_abnormal_hypodermis_morpholog1.76200291
27MP0000049_abnormal_middle_ear1.73427421
28MP0003279_aneurysm1.72442798
29MP0005508_abnormal_skeleton_morphology1.69816085
30MP0000534_abnormal_ureter_morphology1.68367370
31MP0003693_abnormal_embryo_hatching1.66331304
32MP0003880_abnormal_central_pattern1.64988731
33MP0002233_abnormal_nose_morphology1.64066344
34MP0006054_spinal_hemorrhage1.62407143
35MP0003121_genomic_imprinting1.62083089
36MP0003937_abnormal_limbs/digits/tail_de1.61716730
37MP0009384_cardiac_valve_regurgitation1.61407837
38MP0008004_abnormal_stomach_pH1.60848768
39MP0008877_abnormal_DNA_methylation1.57838649
40MP0004957_abnormal_blastocyst_morpholog1.57175997
41MP0003718_maternal_effect1.55929344
42MP0000516_abnormal_urinary_system1.55348317
43MP0005367_renal/urinary_system_phenotyp1.55348317
44MP0003111_abnormal_nucleus_morphology1.55238598
45MP0002249_abnormal_larynx_morphology1.51315628
46MP0005257_abnormal_intraocular_pressure1.49052003
47MP0008007_abnormal_cellular_replicative1.48480848
48* MP0002751_abnormal_autonomic_nervous1.48096763
49MP0006072_abnormal_retinal_apoptosis1.47366086
50MP0010368_abnormal_lymphatic_system1.46538445
51MP0003935_abnormal_craniofacial_develop1.45595440
52MP0009780_abnormal_chondrocyte_physiolo1.44479469
53MP0000733_abnormal_muscle_development1.44082193
54MP0001299_abnormal_eye_distance/1.42098596
55MP0002896_abnormal_bone_mineralization1.41585452
56MP0001958_emphysema1.37830529
57MP0000428_abnormal_craniofacial_morphol1.37489926
58MP0001879_abnormal_lymphatic_vessel1.36462444
59MP0002116_abnormal_craniofacial_bone1.34009879
60MP0002177_abnormal_outer_ear1.31269408
61MP0003123_paternal_imprinting1.27814907
62MP0000569_abnormal_digit_pigmentation1.27412708
63MP0002938_white_spotting1.26834139
64MP0002735_abnormal_chemical_nociception1.26600959
65MP0002084_abnormal_developmental_patter1.26559685
66* MP0002932_abnormal_joint_morphology1.26179284
67MP0003787_abnormal_imprinting1.24297023
68MP0005499_abnormal_olfactory_system1.22048586
69MP0005394_taste/olfaction_phenotype1.22048586
70MP0001177_atelectasis1.21667279
71MP0002234_abnormal_pharynx_morphology1.21640834
72MP0002108_abnormal_muscle_morphology1.21604747
73MP0003091_abnormal_cell_migration1.21548453
74MP0002085_abnormal_embryonic_tissue1.18591012
75MP0000647_abnormal_sebaceous_gland1.18019052
76MP0003115_abnormal_respiratory_system1.16932256
77MP0002109_abnormal_limb_morphology1.16424784
78* MP0003861_abnormal_nervous_system1.16035476
79MP0003077_abnormal_cell_cycle1.15067793
80MP0000631_abnormal_neuroendocrine_gland1.14854795
81MP0009697_abnormal_copulation1.14526082
82MP0000013_abnormal_adipose_tissue1.14431557
83MP0002282_abnormal_trachea_morphology1.12982025
84MP0010352_gastrointestinal_tract_polyps1.11979970
85MP0000163_abnormal_cartilage_morphology1.11008170
86MP0000432_abnormal_head_morphology1.10862393
87MP0000778_abnormal_nervous_system1.10113919
88MP0000537_abnormal_urethra_morphology1.09664812
89MP0003567_abnormal_fetal_cardiomyocyte1.09280024
90MP0005187_abnormal_penis_morphology1.08471274
91MP0002113_abnormal_skeleton_development1.07231310
92MP0002115_abnormal_skeleton_extremities1.06424395
93MP0004197_abnormal_fetal_growth/weight/1.06192288
94MP0004859_abnormal_synaptic_plasticity1.05727865
95MP0000681_abnormal_thyroid_gland1.05652857
96MP0009703_decreased_birth_body1.05652113
97MP0000762_abnormal_tongue_morphology1.03926034
98MP0002876_abnormal_thyroid_physiology1.03148322
99MP0004133_heterotaxia1.02809512
100MP0002736_abnormal_nociception_after1.01924572
101* MP0002184_abnormal_innervation0.99719178
102MP0001984_abnormal_olfaction0.98878675
103MP0002254_reproductive_system_inflammat0.98875838
104MP0001346_abnormal_lacrimal_gland0.98665419
105MP0006292_abnormal_olfactory_placode0.97761591
106MP0008057_abnormal_DNA_replication0.95942358
107MP0001293_anophthalmia0.95885555
108MP0004134_abnormal_chest_morphology0.95874067
109MP0000767_abnormal_smooth_muscle0.94933150
110MP0009672_abnormal_birth_weight0.92914005
111MP0002697_abnormal_eye_size0.91690887
112MP0002734_abnormal_mechanical_nocicepti0.88226621
113MP0005253_abnormal_eye_physiology0.87066709
114MP0005391_vision/eye_phenotype0.85977155
115MP0000462_abnormal_digestive_system0.84823756
116* MP0002114_abnormal_axial_skeleton0.84070552
117MP0001542_abnormal_bone_strength0.83419028
118MP0006138_congestive_heart_failure0.82814499
119MP0002295_abnormal_pulmonary_circulatio0.81928284
120MP0005197_abnormal_uvea_morphology0.80887431
121MP0003283_abnormal_digestive_organ0.80254300
122MP0001340_abnormal_eyelid_morphology0.79681468
123MP0001672_abnormal_embryogenesis/_devel0.79573076
124MP0005380_embryogenesis_phenotype0.79573076
125MP0002090_abnormal_vision0.79551654
126MP0000579_abnormal_nail_morphology0.78870984
127MP0002081_perinatal_lethality0.78233882
128MP0001697_abnormal_embryo_size0.77666214
129MP0001286_abnormal_eye_development0.77056776
130MP0002111_abnormal_tail_morphology0.75949478
131MP0003315_abnormal_perineum_morphology0.75912018
132MP0002925_abnormal_cardiovascular_devel0.74593366
133MP0005408_hypopigmentation0.74113077
134MP0001175_abnormal_lung_morphology0.73789069
135MP0001968_abnormal_touch/_nociception0.71680246
136MP0002063_abnormal_learning/memory/cond0.71314248
137MP0002060_abnormal_skin_morphology0.71043779
138MP0003566_abnormal_cell_adhesion0.68967060
139MP0003938_abnormal_ear_development0.67851865
140MP0005076_abnormal_cell_differentiation0.65343468
141MP0005388_respiratory_system_phenotype0.65037013
142MP0002133_abnormal_respiratory_system0.65037013

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.40323899
2Shallow orbits (HP:0000586)4.34773971
3Protrusio acetabuli (HP:0003179)4.28570814
4Short 4th metacarpal (HP:0010044)4.15906635
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.15906635
6Hepatoblastoma (HP:0002884)3.44280332
7Microglossia (HP:0000171)3.39458915
8Spinal cord lesions (HP:0100561)3.19560220
9Syringomyelia (HP:0003396)3.19560220
10Abnormality of the 4th metacarpal (HP:0010012)3.06854588
11Asymmetry of the thorax (HP:0001555)2.92669329
12Abnormality of dentin (HP:0010299)2.92623848
13Aortic dissection (HP:0002647)2.88161391
14Meckel diverticulum (HP:0002245)2.82939942
15Ependymoma (HP:0002888)2.81716251
16Abnormal lung lobation (HP:0002101)2.79846517
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.78573789
18Bifid tongue (HP:0010297)2.70825427
19Abnormality of the ileum (HP:0001549)2.70234327
20Abnormality of chromosome stability (HP:0003220)2.69236449
21Abnormality of the astrocytes (HP:0100707)2.66437825
22Astrocytoma (HP:0009592)2.66437825
23Mesomelia (HP:0003027)2.57571223
24Increased density of long bones (HP:0006392)2.57155613
25Chromsome breakage (HP:0040012)2.53126407
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52294176
27Colon cancer (HP:0003003)2.51486113
28Soft skin (HP:0000977)2.51126242
29Morphological abnormality of the middle ear (HP:0008609)2.50955911
30Duodenal stenosis (HP:0100867)2.49492818
31Small intestinal stenosis (HP:0012848)2.49492818
32Neonatal short-limb short stature (HP:0008921)2.49419119
33Glioma (HP:0009733)2.48796291
34Intestinal atresia (HP:0011100)2.48241999
35Absent eyebrow (HP:0002223)2.47443266
36Aortic aneurysm (HP:0004942)2.41512552
37Hypoplastic female external genitalia (HP:0012815)2.40446090
38Broad ribs (HP:0000885)2.39745504
39Bell-shaped thorax (HP:0001591)2.39653620
40Volvulus (HP:0002580)2.38410816
41Wrist flexion contracture (HP:0001239)2.38126606
42Labial hypoplasia (HP:0000066)2.37279911
43Cortical dysplasia (HP:0002539)2.34496789
44Dilatation of the ascending aorta (HP:0005111)2.34040683
45Anophthalmia (HP:0000528)2.33932399
46Hypoplastic pelvis (HP:0008839)2.33739901
47Myelomeningocele (HP:0002475)2.33200190
48Abnormality of the duodenum (HP:0002246)2.31692608
49Broad metatarsal (HP:0001783)2.29491564
50Ankle contracture (HP:0006466)2.29312113
51Abnormality of the phalanges of the hallux (HP:0010057)2.29173668
52Natal tooth (HP:0000695)2.27571646
53Oligodactyly (hands) (HP:0001180)2.27466280
54Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.27436589
55Renal hypoplasia (HP:0000089)2.26856156
56Septo-optic dysplasia (HP:0100842)2.25869863
57Bladder diverticulum (HP:0000015)2.25793391
58Cervical subluxation (HP:0003308)2.24844038
59Wormian bones (HP:0002645)2.24053418
60Aqueductal stenosis (HP:0002410)2.22244064
61Atrophic scars (HP:0001075)2.20691411
62Absent frontal sinuses (HP:0002688)2.19320644
63Abnormality of the frontal sinuses (HP:0002687)2.16369450
64Fragile skin (HP:0001030)2.15972629
65Cutaneous finger syndactyly (HP:0010554)2.14133470
66Increased number of teeth (HP:0011069)2.13243154
67Coronal craniosynostosis (HP:0004440)2.12913599
68Hydroureter (HP:0000072)2.12859192
69Follicular hyperkeratosis (HP:0007502)2.07856703
70Peritonitis (HP:0002586)2.06279015
71Rhabdomyosarcoma (HP:0002859)2.05666925
72Long clavicles (HP:0000890)2.03619771
73Abnormality of the labia (HP:0000058)2.03487091
74Nephroblastoma (Wilms tumor) (HP:0002667)2.01648691
75Cupped ear (HP:0000378)2.01408208
76Embryonal renal neoplasm (HP:0011794)1.99426550
77Increased nuchal translucency (HP:0010880)1.99320813
78Overgrowth (HP:0001548)1.98359102
79Abnormal hair whorl (HP:0010721)1.94108393
80Abnormality of the distal phalanx of the thumb (HP:0009617)1.93284762
81Wide anterior fontanel (HP:0000260)1.93172667
82Stenosis of the external auditory canal (HP:0000402)1.92679440
83Abnormality of the preputium (HP:0100587)1.91607049
84Abnormality of the labia minora (HP:0012880)1.91539674
85Neoplasm of the oral cavity (HP:0100649)1.91241083
86Broad toe (HP:0001837)1.90320859
87Broad long bones (HP:0005622)1.90140092
88Narrow nasal bridge (HP:0000446)1.89523327
89Genital tract atresia (HP:0001827)1.88668489
90Facial hemangioma (HP:0000329)1.88534426
91Vaginal atresia (HP:0000148)1.88364047
92Camptodactyly of toe (HP:0001836)1.87727190
93True hermaphroditism (HP:0010459)1.86768128
94Mitral valve prolapse (HP:0001634)1.85985285
95Hypoplasia of the maxilla (HP:0000327)1.85765464
96Joint laxity (HP:0001388)1.83944053
97Delayed gross motor development (HP:0002194)1.83252522
98Scapular winging (HP:0003691)1.83236549
99Medulloblastoma (HP:0002885)1.83132568
100Preaxial hand polydactyly (HP:0001177)1.83119087
101Spinal rigidity (HP:0003306)1.82846024
102Ectopic kidney (HP:0000086)1.82805709
103Small hand (HP:0200055)1.81357830
104Cutaneous syndactyly (HP:0012725)1.80939898
105Abnormality of the carotid arteries (HP:0005344)1.79989708
106Absent radius (HP:0003974)1.79953176
107Micropenis (HP:0000054)1.79307846
108Tibial bowing (HP:0002982)1.78761272
109Oligodactyly (HP:0012165)1.78561642
110Deviation of the hallux (HP:0010051)1.78198291
111Large earlobe (HP:0009748)1.77826298
112Persistence of primary teeth (HP:0006335)1.76198459
113Dislocated radial head (HP:0003083)1.75494102
114Sloping forehead (HP:0000340)1.75438867
115Buphthalmos (HP:0000557)1.74892565
116Midline defect of the nose (HP:0004122)1.74790975
117Renal duplication (HP:0000075)1.74603964
118Dandy-Walker malformation (HP:0001305)1.74133978
119Triphalangeal thumb (HP:0001199)1.74014693
120Blue sclerae (HP:0000592)1.72670700
121Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72549712
122Absent eyelashes (HP:0000561)1.72549344
123Abnormality of the nasal septum (HP:0000419)1.71789092
124Hallux valgus (HP:0001822)1.71180705
125Abnormality of incisor morphology (HP:0011063)1.71005249
126Type 1 muscle fiber predominance (HP:0003803)1.70602763
127Aplasia involving forearm bones (HP:0009822)1.70216196
128Absent forearm bone (HP:0003953)1.70216196
129Complete atrioventricular canal defect (HP:0001674)1.69565864
130Abnormality of the pubic bones (HP:0003172)1.69204667
131Broad phalanx (HP:0006009)1.69057195
132Broad foot (HP:0001769)1.68863144
133Vascular tortuosity (HP:0004948)1.68750408
134Cerebral aneurysm (HP:0004944)1.68327375
135Genu recurvatum (HP:0002816)1.68051291
136Bowel diverticulosis (HP:0005222)1.68012066
137Postaxial hand polydactyly (HP:0001162)1.67934502
138Abnormality of the antihelix (HP:0009738)1.67856904
139Short middle phalanx of the 5th finger (HP:0004220)1.67279036
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.67192280
141Broad-based gait (HP:0002136)1.67166235
142Broad thumb (HP:0011304)1.65739382
143Infantile muscular hypotonia (HP:0008947)1.65459747
144Abnormality of the radial head (HP:0003995)1.64502268
145Mild short stature (HP:0003502)1.64365448
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64260880
147Slender build (HP:0001533)1.63769113
148Pancreatic fibrosis (HP:0100732)1.63626666
149Horseshoe kidney (HP:0000085)1.62368947
150Hypoplastic labia majora (HP:0000059)1.61706348
151Birth length less than 3rd percentile (HP:0003561)1.61220896
152Scrotal hypoplasia (HP:0000046)1.60307886
153Abnormality of the aortic arch (HP:0012303)1.60249649
154Advanced eruption of teeth (HP:0006288)1.60021301
155Tracheomalacia (HP:0002779)1.59886813
156Optic nerve hypoplasia (HP:0000609)1.59877703
157Skull defect (HP:0001362)1.59812337
158Drooling (HP:0002307)1.59654397
159Preaxial foot polydactyly (HP:0001841)1.59389633
160Gait imbalance (HP:0002141)1.59341600
161Deep philtrum (HP:0002002)1.58903173
162Vitreoretinal degeneration (HP:0000655)1.58153948
163Abnormality of the labia majora (HP:0012881)1.57726962
164Hyperextensible skin (HP:0000974)1.57412892
165Abnormality of the fetal cardiovascular system (HP:0010948)1.57023710
166Abnormal umbilical cord blood vessels (HP:0011403)1.57023710
167Single umbilical artery (HP:0001195)1.57023710
168Omphalocele (HP:0001539)1.56979983
169Narrow forehead (HP:0000341)1.56724701
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.56580429
171Medial flaring of the eyebrow (HP:0010747)1.56226688
172Focal motor seizures (HP:0011153)1.56204896
173Broad finger (HP:0001500)1.56011817
174Astigmatism (HP:0000483)1.55231074
175Absent speech (HP:0001344)1.55172750
176Congenital primary aphakia (HP:0007707)1.54632513
177Gastrointestinal atresia (HP:0002589)1.54615405
178Spastic diplegia (HP:0001264)1.54106474
179Febrile seizures (HP:0002373)1.53794028
180Broad hallux (HP:0010055)1.53557766
181Chorioretinal coloboma (HP:0000567)1.51037223
182Neoplasm of striated muscle (HP:0009728)1.50959169
183Facial cleft (HP:0002006)1.50030051
184Bilateral microphthalmos (HP:0007633)1.48776308
185Pancreatic cysts (HP:0001737)1.48316575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.71245114
2AKT33.72444154
3TNIK3.41146999
4PLK23.36129790
5ERBB33.35929978
6WNK33.19566877
7DDR23.08378919
8LATS12.96415799
9TRIM282.59702297
10EPHA32.50824944
11BUB12.48608541
12FRK2.34430602
13TTK2.24209925
14PRPF4B2.16583177
15MAP3K42.14150668
16EPHB22.13591533
17TTN2.08731932
18EIF2AK32.05857851
19NUAK11.91164862
20CDC71.88519398
21ZAK1.75784159
22TRPM71.71480543
23MAP2K71.68995078
24SGK21.62835297
25PDGFRA1.58850238
26SRPK11.57201491
27CCNB11.55838580
28DAPK21.55103578
29BRSK21.52843857
30STK38L1.50153787
31BMPR21.49525381
32BMPR1B1.45769983
33EIF2AK11.43751934
34LIMK11.41155689
35NEK11.37469873
36WEE11.36963713
37MARK11.36276111
38ACVR1B1.35215061
39PLK11.32277595
40SIK31.32240087
41PIK3CA1.31152167
42PLK31.24657270
43TESK11.22081036
44MAP3K121.20162692
45MET1.19764383
46EPHA41.19111793
47EIF2AK21.18374746
48MKNK11.16848037
49DYRK21.15410445
50STK31.12405627
51YES11.10939745
52CDK81.09305158
53PAK31.08782667
54BCR1.08603244
55MAPK131.08392847
56SGK31.07308758
57CDK191.07073193
58FGFR11.06973394
59BRD41.06220753
60PTK2B1.01741371
61MAP4K21.01599579
62MST41.01499254
63SGK2231.00237204
64SGK4941.00237204
65FGFR20.99509770
66LATS20.98754682
67MYLK0.98746460
68FER0.98647357
69SIK10.98369887
70CSNK1G10.90113569
71ROCK10.89690095
72MKNK20.87302133
73NTRK30.87220568
74KSR10.84899887
75FLT30.84887163
76CSNK1G20.81229924
77VRK10.78578034
78PRKCE0.78428881
79BRSK10.74148998
80ADRBK10.72143912
81RPS6KA40.71719165
82KDR0.71351564
83MINK10.69469858
84DAPK10.68584337
85FGFR30.68006054
86CAMKK20.67700493
87NTRK10.67094350
88ATM0.66898362
89PBK0.66406812
90TGFBR10.65833916
91NEK90.65588511
92MST1R0.64361650
93TSSK60.63823711
94TAF10.63393418
95CHEK20.62669176
96CSNK1G30.59986186
97VRK20.59263488
98CSNK1A1L0.59118070
99PAK20.58595398
100ATR0.58588693
101CAMK40.57905890
102PAK60.57192167
103BRAF0.57008328
104PNCK0.56869216
105CDK180.56375886
106PRKCH0.56105601
107CLK10.55691199
108DYRK30.55183682
109MAP2K10.54705115
110MOS0.52899373
111DMPK0.51222404
112CAMK2A0.51005891
113MAPK70.50767001
114ROCK20.50622555
115PLK40.50056983
116CDC42BPA0.49765784
117PRKCG0.49497862
118RPS6KA20.49376114
119SGK10.48844136
120PDGFRB0.46394280
121CHEK10.45946415
122TGFBR20.45834798
123BMX0.45721247
124CDK140.45609234
125CDK150.45461369
126MELK0.44624753
127ADRBK20.44490537
128AURKB0.44289593
129TAOK20.44077338
130PTK20.44022499
131PRKDC0.43970984
132GRK50.43770962
133OXSR10.39924034
134STK240.38594833
135EPHA20.38341647
136GRK70.37659358
137NEK20.37442962
138TIE10.36611490
139STK390.34654490
140GRK10.34402333
141INSRR0.33884958
142CDK30.33574420
143DAPK30.33451413
144CDK50.32973841
145MAP2K40.31873283
146CAMK2B0.30362818
147JAK10.30108150
148CDK11A0.29507885
149ERBB40.28737966
150PAK40.27977580

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.28555446
2Steroid biosynthesis_Homo sapiens_hsa001003.34642949
3Proteasome_Homo sapiens_hsa030502.40381497
4Mismatch repair_Homo sapiens_hsa034302.39666816
5Fanconi anemia pathway_Homo sapiens_hsa034602.17631037
6Homologous recombination_Homo sapiens_hsa034402.17566009
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.12998056
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05108950
9Protein export_Homo sapiens_hsa030602.03249850
10Basal cell carcinoma_Homo sapiens_hsa052172.00297913
11Olfactory transduction_Homo sapiens_hsa047402.00227226
12Propanoate metabolism_Homo sapiens_hsa006401.93523026
13DNA replication_Homo sapiens_hsa030301.90289316
14Basal transcription factors_Homo sapiens_hsa030221.90208962
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.87698372
16ECM-receptor interaction_Homo sapiens_hsa045121.83185773
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82199149
18RNA transport_Homo sapiens_hsa030131.80567866
19Focal adhesion_Homo sapiens_hsa045101.75612728
20Nicotine addiction_Homo sapiens_hsa050331.75057209
21Hippo signaling pathway_Homo sapiens_hsa043901.72046040
22Adherens junction_Homo sapiens_hsa045201.69077426
23Synaptic vesicle cycle_Homo sapiens_hsa047211.68090688
24* Axon guidance_Homo sapiens_hsa043601.66700526
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.65288015
26Dilated cardiomyopathy_Homo sapiens_hsa054141.62868276
27RNA degradation_Homo sapiens_hsa030181.62150443
28Circadian entrainment_Homo sapiens_hsa047131.57974557
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.57939449
30Proteoglycans in cancer_Homo sapiens_hsa052051.55857769
31Hedgehog signaling pathway_Homo sapiens_hsa043401.55390952
32Nucleotide excision repair_Homo sapiens_hsa034201.55126463
33Vitamin B6 metabolism_Homo sapiens_hsa007501.54298220
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54058780
35RNA polymerase_Homo sapiens_hsa030201.51461053
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49982153
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49119241
38Melanoma_Homo sapiens_hsa052181.48591629
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40818166
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39337174
41TGF-beta signaling pathway_Homo sapiens_hsa043501.38402802
42Wnt signaling pathway_Homo sapiens_hsa043101.35696619
43MicroRNAs in cancer_Homo sapiens_hsa052061.35670294
44GnRH signaling pathway_Homo sapiens_hsa049121.29750604
45Collecting duct acid secretion_Homo sapiens_hsa049661.27514043
46Glioma_Homo sapiens_hsa052141.27134602
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26403819
48Long-term potentiation_Homo sapiens_hsa047201.25785834
49Vibrio cholerae infection_Homo sapiens_hsa051101.24641240
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24212456
51Amphetamine addiction_Homo sapiens_hsa050311.23382974
52Melanogenesis_Homo sapiens_hsa049161.23150179
53Base excision repair_Homo sapiens_hsa034101.22149900
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20734924
55Morphine addiction_Homo sapiens_hsa050321.20342544
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20006295
57Colorectal cancer_Homo sapiens_hsa052101.18581121
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18110829
59Pyruvate metabolism_Homo sapiens_hsa006201.14996130
60Endometrial cancer_Homo sapiens_hsa052131.14446829
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14294782
62Phagosome_Homo sapiens_hsa041451.13974342
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13838378
64Gap junction_Homo sapiens_hsa045401.12965230
65Oocyte meiosis_Homo sapiens_hsa041141.12455116
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12302699
67Malaria_Homo sapiens_hsa051441.11625277
68mRNA surveillance pathway_Homo sapiens_hsa030151.08920778
69FoxO signaling pathway_Homo sapiens_hsa040681.07763731
70Spliceosome_Homo sapiens_hsa030401.07663977
71Ovarian steroidogenesis_Homo sapiens_hsa049131.06167720
72One carbon pool by folate_Homo sapiens_hsa006701.04904191
73Fatty acid elongation_Homo sapiens_hsa000621.04795845
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04741489
75Long-term depression_Homo sapiens_hsa047301.04036059
76Dopaminergic synapse_Homo sapiens_hsa047281.03655863
77Rap1 signaling pathway_Homo sapiens_hsa040151.03165139
78Rheumatoid arthritis_Homo sapiens_hsa053231.03104352
79Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02434874
80Taste transduction_Homo sapiens_hsa047421.02194326
81Oxytocin signaling pathway_Homo sapiens_hsa049211.01525407
82Renin secretion_Homo sapiens_hsa049241.01241178
83ErbB signaling pathway_Homo sapiens_hsa040121.00989563
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00895278
85Cholinergic synapse_Homo sapiens_hsa047250.97998335
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97029609
87Prostate cancer_Homo sapiens_hsa052150.96396263
88Tight junction_Homo sapiens_hsa045300.96083538
89Glutamatergic synapse_Homo sapiens_hsa047240.96002270
90Bladder cancer_Homo sapiens_hsa052190.94802690
91Serotonergic synapse_Homo sapiens_hsa047260.94461786
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94328679
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91878409
94Pancreatic cancer_Homo sapiens_hsa052120.90882171
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90226486
96Pathways in cancer_Homo sapiens_hsa052000.89548891
97HTLV-I infection_Homo sapiens_hsa051660.89496508
98p53 signaling pathway_Homo sapiens_hsa041150.89298157
99Amoebiasis_Homo sapiens_hsa051460.89172176
100Phototransduction_Homo sapiens_hsa047440.88305063
101Small cell lung cancer_Homo sapiens_hsa052220.88217275
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87395201
103Selenocompound metabolism_Homo sapiens_hsa004500.84857580
104Ras signaling pathway_Homo sapiens_hsa040140.84661487
105Biosynthesis of amino acids_Homo sapiens_hsa012300.84349635
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83920537
107MAPK signaling pathway_Homo sapiens_hsa040100.83870061
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82112292
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81985592
110TNF signaling pathway_Homo sapiens_hsa046680.80865101
111Chronic myeloid leukemia_Homo sapiens_hsa052200.80175905
112Cell cycle_Homo sapiens_hsa041100.79638566
113Purine metabolism_Homo sapiens_hsa002300.79337588
114cAMP signaling pathway_Homo sapiens_hsa040240.78996545
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77956691
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77790291
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77694648
118Gastric acid secretion_Homo sapiens_hsa049710.77694239
119Pyrimidine metabolism_Homo sapiens_hsa002400.77203866
120Lysine degradation_Homo sapiens_hsa003100.77059169
121Salivary secretion_Homo sapiens_hsa049700.75954268
122Cocaine addiction_Homo sapiens_hsa050300.75624080
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74472100
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73938400
125Calcium signaling pathway_Homo sapiens_hsa040200.73805921
126Type II diabetes mellitus_Homo sapiens_hsa049300.73506765
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72143774
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71355745
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.67468600
130GABAergic synapse_Homo sapiens_hsa047270.66996998
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66537870
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.66170934
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65784723
134African trypanosomiasis_Homo sapiens_hsa051430.65282938
135Viral myocarditis_Homo sapiens_hsa054160.63746521
136Estrogen signaling pathway_Homo sapiens_hsa049150.63568229
137Alcoholism_Homo sapiens_hsa050340.62145107
138Fatty acid metabolism_Homo sapiens_hsa012120.61786364
139N-Glycan biosynthesis_Homo sapiens_hsa005100.61565067
140Autoimmune thyroid disease_Homo sapiens_hsa053200.60701759
141Insulin secretion_Homo sapiens_hsa049110.60552665
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60363565
143Renal cell carcinoma_Homo sapiens_hsa052110.59846127
144Carbon metabolism_Homo sapiens_hsa012000.59353850
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59185195
146Non-small cell lung cancer_Homo sapiens_hsa052230.58513400
147Salmonella infection_Homo sapiens_hsa051320.57658279
148Glutathione metabolism_Homo sapiens_hsa004800.56948730
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54047144
150Protein digestion and absorption_Homo sapiens_hsa049740.47231330
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44809133
152Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41601696
153Vitamin digestion and absorption_Homo sapiens_hsa049770.40714443
154beta-Alanine metabolism_Homo sapiens_hsa004100.35411949
155Primary bile acid biosynthesis_Homo sapiens_hsa001200.34508045
156Metabolic pathways_Homo sapiens_hsa011000.34252323
157Butanoate metabolism_Homo sapiens_hsa006500.33399593

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