SEMA3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.32910577
2bundle of His cell to Purkinje myocyte communication (GO:0086069)5.00898953
3plasma membrane repair (GO:0001778)4.68122566
4cell-cell junction maintenance (GO:0045217)4.44922721
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.29857439
6glomerular basement membrane development (GO:0032836)4.26724205
7myelination in peripheral nervous system (GO:0022011)4.18269686
8peripheral nervous system axon ensheathment (GO:0032292)4.18269686
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.02783402
10angiotensin maturation (GO:0002003)3.97885375
11cell junction maintenance (GO:0034331)3.96001486
12epithelial cell-cell adhesion (GO:0090136)3.92821926
13sarcomere organization (GO:0045214)3.91820877
14renal filtration (GO:0097205)3.80218185
15central nervous system myelination (GO:0022010)3.74124962
16axon ensheathment in central nervous system (GO:0032291)3.74124962
17glomerular visceral epithelial cell development (GO:0072015)3.73431603
18myelin maintenance (GO:0043217)3.72284767
19cytoskeletal anchoring at plasma membrane (GO:0007016)3.58754921
20intestinal absorption (GO:0050892)3.58339625
21basement membrane organization (GO:0071711)3.54463331
22negative regulation of potassium ion transmembrane transport (GO:1901380)3.54086539
23ventricular cardiac muscle cell action potential (GO:0086005)3.53565940
24cell adhesion mediated by integrin (GO:0033627)3.52708202
25sodium ion export (GO:0071436)3.50535383
26glomerular epithelial cell development (GO:0072310)3.49125574
27actin-myosin filament sliding (GO:0033275)3.46360537
28muscle filament sliding (GO:0030049)3.46360537
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.42587067
30regulation of cholesterol homeostasis (GO:2000188)3.39755386
31very-low-density lipoprotein particle assembly (GO:0034379)3.29060151
32cell-substrate junction assembly (GO:0007044)3.26397845
33actin-mediated cell contraction (GO:0070252)3.25269714
34NADH metabolic process (GO:0006734)3.24174485
35cell communication involved in cardiac conduction (GO:0086065)3.22995063
36regulation of skeletal muscle contraction (GO:0014819)3.22787467
37regulation of cholesterol biosynthetic process (GO:0045540)3.20699850
38regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.12867956
39protein-lipid complex assembly (GO:0065005)3.11340818
40regulation of bile acid biosynthetic process (GO:0070857)3.11195114
41vitamin transmembrane transport (GO:0035461)3.09415824
42plasma lipoprotein particle assembly (GO:0034377)3.08655125
43estrogen biosynthetic process (GO:0006703)3.08249307
44actomyosin structure organization (GO:0031032)3.06451127
45negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.04004631
46regulation of cholesterol metabolic process (GO:0090181)3.03560540
47cardiac myofibril assembly (GO:0055003)3.03412077
48regulation of p38MAPK cascade (GO:1900744)3.01208464
49protein retention in ER lumen (GO:0006621)2.98376187
50heart trabecula formation (GO:0060347)2.96399513
51diacylglycerol metabolic process (GO:0046339)2.94086507
52branching involved in salivary gland morphogenesis (GO:0060445)2.93379265
53glucocorticoid biosynthetic process (GO:0006704)2.93101241
54glomerular filtration (GO:0003094)2.90614435
55actin filament-based movement (GO:0030048)2.88848118
56positive regulation of synapse maturation (GO:0090129)2.87690586
57collagen fibril organization (GO:0030199)2.86642879
58cellular potassium ion homeostasis (GO:0030007)2.83441390
59cardiac muscle contraction (GO:0060048)2.82640964
60regulation of extracellular matrix disassembly (GO:0010715)2.82617190
61positive regulation of p38MAPK cascade (GO:1900745)2.82256931
62renal absorption (GO:0070293)2.82254420
63regulation of cholesterol esterification (GO:0010872)2.82152352
64regulation of actin filament-based movement (GO:1903115)2.81768933
65glutamate secretion (GO:0014047)2.81647702
66protein heterotrimerization (GO:0070208)2.81299232
67endodermal cell differentiation (GO:0035987)2.79269129
68lung epithelium development (GO:0060428)2.78608059
69lipoprotein transport (GO:0042953)2.78547003
70regulation of systemic arterial blood pressure by hormone (GO:0001990)2.76656125
71regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.76656125
72endocrine process (GO:0050886)2.76656125
73maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.76445870
74renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.76154303
75myofibril assembly (GO:0030239)2.75310225
76renal system process involved in regulation of blood volume (GO:0001977)2.74633988
77protein targeting to plasma membrane (GO:0072661)2.73519995
78surfactant homeostasis (GO:0043129)2.73194072
79multicellular organismal macromolecule metabolic process (GO:0044259)2.70665741
80cellular sodium ion homeostasis (GO:0006883)2.70303520
81regulation of guanylate cyclase activity (GO:0031282)2.69714215
82multicellular organismal catabolic process (GO:0044243)2.68465536
83cGMP-mediated signaling (GO:0019934)2.67924489
84positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.67655622
85adhesion of symbiont to host (GO:0044406)2.66775286
86collagen metabolic process (GO:0032963)2.66585528
87fructose metabolic process (GO:0006000)2.62373081
88collagen catabolic process (GO:0030574)2.62134520
89regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.61922245
90positive regulation of triglyceride lipase activity (GO:0061365)2.60803485
91positive regulation of lipoprotein lipase activity (GO:0051006)2.60803485
92glutamine family amino acid biosynthetic process (GO:0009084)2.60784402
93COPI coating of Golgi vesicle (GO:0048205)2.60707190
94Golgi transport vesicle coating (GO:0048200)2.60707190
95extracellular matrix disassembly (GO:0022617)2.60421842
96actin filament depolymerization (GO:0030042)2.59833392
97multicellular organismal metabolic process (GO:0044236)2.59581426
98desmosome organization (GO:0002934)2.59437055
99proline metabolic process (GO:0006560)2.57347077
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.56749985
101regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.56224450
102lipoprotein metabolic process (GO:0042157)2.56042400
103proline biosynthetic process (GO:0006561)2.54918013
104negative regulation of fatty acid transport (GO:2000192)2.53884904
105carnitine shuttle (GO:0006853)2.53023583
106low-density lipoprotein particle remodeling (GO:0034374)2.52015816
107glial cell proliferation (GO:0014009)2.51782633
108cardiac muscle cell development (GO:0055013)2.51007162
109tricarboxylic acid cycle (GO:0006099)2.48575283
110negative regulation of catenin import into nucleus (GO:0035414)2.48557036
111urea cycle (GO:0000050)2.48274304
112cell volume homeostasis (GO:0006884)2.48037005
113stress fiber assembly (GO:0043149)2.47896917
114regulation of systemic arterial blood pressure (GO:0003073)2.47082455
115regulation of apoptotic cell clearance (GO:2000425)2.47018621
116protein localization to endosome (GO:0036010)2.46200211
117sodium ion homeostasis (GO:0055078)2.45951838
118vascular endothelial growth factor signaling pathway (GO:0038084)2.45673734
119phosphate ion transmembrane transport (GO:0035435)2.45276479
120peptidyl-tyrosine autophosphorylation (GO:0038083)2.44242888
121camera-type eye morphogenesis (GO:0048593)2.44045072
122cardiac cell development (GO:0055006)2.42942002
123regulation of cardiac muscle cell contraction (GO:0086004)2.42766242
124mesodermal cell differentiation (GO:0048333)2.42703266
125skeletal muscle adaptation (GO:0043501)2.42482447
126regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.42332782
127regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.42286561
128semaphorin-plexin signaling pathway (GO:0071526)2.41827301
129cell-substrate adherens junction assembly (GO:0007045)2.41571133
130focal adhesion assembly (GO:0048041)2.41571133
131amino acid import (GO:0043090)2.41518513
132intestinal cholesterol absorption (GO:0030299)2.41454918
133regulation of cardioblast differentiation (GO:0051890)2.40707961
134cellular response to nitric oxide (GO:0071732)2.40235906
135endocardial cushion development (GO:0003197)2.39337589
136endocrine hormone secretion (GO:0060986)2.39261786
137striated muscle contraction (GO:0006941)2.38661301
138protein-lipid complex remodeling (GO:0034368)2.38491888
139macromolecular complex remodeling (GO:0034367)2.38491888
140plasma lipoprotein particle remodeling (GO:0034369)2.38491888
141regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.37441247
142retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37440053
143neuronal ion channel clustering (GO:0045161)2.37272884
144cellular component maintenance (GO:0043954)2.37264268
145activation of Rac GTPase activity (GO:0032863)2.37003438
146protein-lipid complex subunit organization (GO:0071825)2.36495943
147triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.36477323
148regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.35984486
149cardiac muscle cell action potential (GO:0086001)2.33826821
150response to follicle-stimulating hormone (GO:0032354)2.33606775
151membrane repolarization during action potential (GO:0086011)2.33334445
152positive regulation of pseudopodium assembly (GO:0031274)2.33316659
153mannose metabolic process (GO:0006013)2.33025015
154relaxation of cardiac muscle (GO:0055119)2.32962803
155bone morphogenesis (GO:0060349)2.32035610
156regulation of early endosome to late endosome transport (GO:2000641)2.31736814
157skin development (GO:0043588)2.31656899
158trabecula formation (GO:0060343)2.31019086
159female pregnancy (GO:0007565)2.31018147
160growth hormone receptor signaling pathway (GO:0060396)2.30896448
161creatine metabolic process (GO:0006600)2.30869816
162amino-acid betaine transport (GO:0015838)2.30763884
163carnitine transport (GO:0015879)2.30763884
164plasma lipoprotein particle organization (GO:0071827)2.30281077
165endothelial cell morphogenesis (GO:0001886)2.27666690
166cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.27593794
167cardiac muscle cell action potential involved in contraction (GO:0086002)2.27142249
168regulation of synapse maturation (GO:0090128)2.26820366
169adhesion of symbiont to host cell (GO:0044650)2.26686564
170virion attachment to host cell (GO:0019062)2.26686564
171renal system development (GO:0072001)2.26267984
172cardiac muscle cell proliferation (GO:0060038)2.25732421
173membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.25694631
174positive regulation of cellular amine metabolic process (GO:0033240)2.25475971
175regulation of integrin-mediated signaling pathway (GO:2001044)2.25048463
176positive regulation of steroid metabolic process (GO:0045940)2.24793883
177cell communication by electrical coupling (GO:0010644)2.23961163
178muscle contraction (GO:0006936)2.22413501
179glomerulus development (GO:0032835)2.21119430
180skin morphogenesis (GO:0043589)2.18272035
181adherens junction assembly (GO:0034333)2.17477118
182chemical homeostasis within a tissue (GO:0048875)2.17399418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.60261747
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.86407036
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.83236946
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.45506753
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.25358486
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.81278937
7ZNF263_19887448_ChIP-Seq_K562_Human2.77928446
8* ESR2_21235772_ChIP-Seq_MCF-7_Human2.61230353
9CLOCK_20551151_ChIP-Seq_293T_Human2.44351476
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.22987573
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.22241086
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18103266
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.14752456
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.99357961
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.97453611
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.90846817
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88504927
18PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82803890
19TBX20_22080862_ChIP-Seq_HEART_Mouse1.77125656
20TBX20_22328084_ChIP-Seq_HEART_Mouse1.77125656
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76562463
22* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74991654
23DNAJC2_21179169_ChIP-ChIP_NT2_Human1.69568728
24* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62487126
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59830369
26CTCF_27219007_Chip-Seq_Bcells_Human1.59634743
27* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58887985
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.58738188
29* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55778809
30* RACK7_27058665_Chip-Seq_MCF-7_Human1.52620248
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52143655
32CJUN_26792858_Chip-Seq_BT549_Human1.49864362
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.48100030
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47491547
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44580049
36CDX2_20551321_ChIP-Seq_CACO-2_Human1.43536326
37* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41854894
38SMC4_20622854_ChIP-Seq_HELA_Human1.41846822
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41484142
40CREB1_26743006_Chip-Seq_LNCaP_Human1.40910682
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40112232
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39595606
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39416821
44* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39121990
45* P68_20966046_ChIP-Seq_HELA_Human1.38467250
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37895667
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37537162
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.37205563
49SOX2_20726797_ChIP-Seq_SW620_Human1.36358653
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35994760
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35465972
52* ELK3_25401928_ChIP-Seq_HUVEC_Human1.35096826
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34648561
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34489818
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30510723
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29412762
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.29281681
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28545690
59ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27996562
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27755336
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27755336
62* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27450722
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27166587
64KDM2B_26808549_Chip-Seq_K562_Human1.26791978
65* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24379048
66* LXR_22292898_ChIP-Seq_THP-1_Human1.23090719
67* RUNX1_27514584_Chip-Seq_MCF-7_Human1.23056215
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22658300
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22036218
70* AHR_22903824_ChIP-Seq_MCF-7_Human1.22004868
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21691965
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21691965
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21250948
74* TCF7_22412390_ChIP-Seq_EML_Mouse1.19952146
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19292214
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17962266
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17574691
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17563776
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16631321
80* ATF3_27146783_Chip-Seq_COLON_Human1.16418433
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15709944
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14748851
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14661589
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14574484
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.14319493
86TP53_22127205_ChIP-Seq_IMR90_Human1.14244030
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.13613673
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.13271354
89TET1_21490601_ChIP-Seq_MESCs_Mouse1.12887275
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12678646
91* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11928786
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11864964
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11000155
94DROSHA_22980978_ChIP-Seq_HELA_Human1.10827520
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10477907
96LXR_22158963_ChIP-Seq_LIVER_Mouse1.10381273
97RARB_27405468_Chip-Seq_BRAIN_Mouse1.10072402
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09560587
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09267246
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08989587
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08343611
102* TP63_22573176_ChIP-Seq_HFKS_Human1.08001507
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07017787
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06011193
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05854550
106KLF5_25053715_ChIP-Seq_YYC3_Human1.05403903
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04941018
108TP53_16413492_ChIP-PET_HCT116_Human1.04807943
109GATA4_25053715_ChIP-Seq_YYC3_Human1.04588257
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01687196
111SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00486550
112* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00415915
113GATA6_25053715_ChIP-Seq_YYC3_Human0.99649441
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98484859
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.96731803
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96418955
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96251709
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96062950
119JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95884131
120JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95526401
121SA1_27219007_Chip-Seq_Bcells_Human0.95524998
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95298758
123PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94828551
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94464430
125* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94193477
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93712934
127* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93159886
128KDM2B_26808549_Chip-Seq_DND41_Human0.91767737
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.91724860
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91587833
131TCF4_18268006_ChIP-ChIP_LS174T_Human0.90591331
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90251346
133RXR_22158963_ChIP-Seq_LIVER_Mouse0.89694966
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.88911747
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88254438
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88254438

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.71911134
2MP0004272_abnormal_basement_membrane4.30612373
3MP0000751_myopathy3.93344169
4MP0005275_abnormal_skin_tensile3.65750304
5MP0000749_muscle_degeneration3.11223797
6MP0001666_abnormal_nutrient_absorption2.99611605
7MP0002837_dystrophic_cardiac_calcinosis2.97063209
8MP0005409_darkened_coat_color2.93059208
9MP0004084_abnormal_cardiac_muscle2.87313880
10MP0005503_abnormal_tendon_morphology2.56284331
11MP0001958_emphysema2.52074510
12MP0005623_abnormal_meninges_morphology2.48032547
13MP0000566_synostosis2.37876606
14MP0009780_abnormal_chondrocyte_physiolo2.34856193
15MP0003045_fibrosis2.32349818
16MP0003705_abnormal_hypodermis_morpholog2.23990027
17MP0004019_abnormal_vitamin_homeostasis2.17698931
18MP0003183_abnormal_peptide_metabolism2.15931992
19MP0004858_abnormal_nervous_system2.15488416
20MP0000747_muscle_weakness2.15197155
21MP0003879_abnormal_hair_cell2.14396780
22MP0004270_analgesia2.11576584
23MP0005058_abnormal_lysosome_morphology2.06777911
24MP0000750_abnormal_muscle_regeneration2.06250422
25MP0005365_abnormal_bile_salt2.03811975
26MP0004036_abnormal_muscle_relaxation2.02165602
27MP0005330_cardiomyopathy2.01873168
28MP0004087_abnormal_muscle_fiber1.95253430
29MP0010329_abnormal_lipoprotein_level1.91154847
30MP0003279_aneurysm1.87926709
31MP0005085_abnormal_gallbladder_physiolo1.84578912
32MP0004859_abnormal_synaptic_plasticity1.78761773
33MP0004264_abnormal_extraembryonic_tissu1.75238664
34MP0005171_absent_coat_pigmentation1.74607016
35MP0003283_abnormal_digestive_organ1.71998255
36MP0003566_abnormal_cell_adhesion1.68380331
37MP0004215_abnormal_myocardial_fiber1.67958393
38MP0000678_abnormal_parathyroid_gland1.65219358
39MP0005083_abnormal_biliary_tract1.63073480
40MP0010234_abnormal_vibrissa_follicle1.62683759
41MP0002108_abnormal_muscle_morphology1.60716848
42MP0002269_muscular_atrophy1.58237162
43MP0002972_abnormal_cardiac_muscle1.58141492
44MP0004233_abnormal_muscle_weight1.51718910
45MP0002139_abnormal_hepatobiliary_system1.45627803
46MP0000462_abnormal_digestive_system1.43413483
47MP0003172_abnormal_lysosome_physiology1.42623821
48MP0000534_abnormal_ureter_morphology1.42358022
49MP0008260_abnormal_autophagy1.40457107
50MP0002249_abnormal_larynx_morphology1.39376703
51MP0000920_abnormal_myelination1.39181882
52MP0000537_abnormal_urethra_morphology1.38437406
53MP0005620_abnormal_muscle_contractility1.38336565
54MP0002106_abnormal_muscle_physiology1.37941665
55MP0009384_cardiac_valve_regurgitation1.37780112
56MP0003646_muscle_fatigue1.33227660
57MP0006138_congestive_heart_failure1.32779559
58MP0005076_abnormal_cell_differentiation1.32720742
59MP0003950_abnormal_plasma_membrane1.32361561
60MP0004484_altered_response_of1.31375849
61MP0003300_gastrointestinal_ulcer1.30735421
62MP0000733_abnormal_muscle_development1.30622033
63MP0000759_abnormal_skeletal_muscle1.30473139
64MP0001664_abnormal_digestion1.30311154
65MP0010030_abnormal_orbit_morphology1.29628235
66MP0001544_abnormal_cardiovascular_syste1.29399059
67MP0005385_cardiovascular_system_phenoty1.29399059
68MP0005369_muscle_phenotype1.29118393
69MP0002168_other_aberrant_phenotype1.28462542
70MP0002060_abnormal_skin_morphology1.27185634
71MP0010630_abnormal_cardiac_muscle1.27084019
72MP0002877_abnormal_melanocyte_morpholog1.24109579
73MP0004145_abnormal_muscle_electrophysio1.22420770
74MP0004130_abnormal_muscle_cell1.22100830
75MP0003690_abnormal_glial_cell1.21572691
76MP0008775_abnormal_heart_ventricle1.20907459
77MP0003453_abnormal_keratinocyte_physiol1.20386786
78MP0001348_abnormal_lacrimal_gland1.20152963
79MP0005451_abnormal_body_composition1.19460653
80MP0005666_abnormal_adipose_tissue1.18540496
81MP0005377_hearing/vestibular/ear_phenot1.16559358
82MP0003878_abnormal_ear_physiology1.16559358
83MP0001849_ear_inflammation1.14894685
84MP0002971_abnormal_brown_adipose1.14114458
85MP0005023_abnormal_wound_healing1.13639787
86MP0009840_abnormal_foam_cell1.12018538
87MP0005423_abnormal_somatic_nervous1.11537996
88MP0000013_abnormal_adipose_tissue1.10649682
89MP0003091_abnormal_cell_migration1.09670872
90MP0003123_paternal_imprinting1.07774684
91MP0002254_reproductive_system_inflammat1.06585958
92MP0006054_spinal_hemorrhage1.05927285
93MP0002896_abnormal_bone_mineralization1.05391687
94MP0008004_abnormal_stomach_pH1.04097513
95MP0000604_amyloidosis1.03612098
96MP0002118_abnormal_lipid_homeostasis1.02815669
97MP0004185_abnormal_adipocyte_glucose1.02298293
98MP0000372_irregular_coat_pigmentation1.01997746
99MP0005408_hypopigmentation1.00171547
100MP0005375_adipose_tissue_phenotype0.99644297
101MP0000762_abnormal_tongue_morphology0.97272400
102MP0003634_abnormal_glial_cell0.96872814
103MP0003137_abnormal_impulse_conducting0.96206602
104MP0008569_lethality_at_weaning0.95956333
105MP0005332_abnormal_amino_acid0.94530591
106MP0005257_abnormal_intraocular_pressure0.93734510
107MP0005670_abnormal_white_adipose0.93574259
108MP0001502_abnormal_circadian_rhythm0.92548119
109MP0005508_abnormal_skeleton_morphology0.91716278
110MP0009379_abnormal_foot_pigmentation0.91589303
111MP0000681_abnormal_thyroid_gland0.89715316
112MP0002876_abnormal_thyroid_physiology0.88468043
113MP0003329_amyloid_beta_deposits0.87549248
114MP0000003_abnormal_adipose_tissue0.86935331
115MP0005165_increased_susceptibility_to0.86175803
116MP0001299_abnormal_eye_distance/0.86092887
117MP0001756_abnormal_urination0.84723810
118MP0009643_abnormal_urine_homeostasis0.84701072
119MP0004782_abnormal_surfactant_physiolog0.84270745
120MP0002933_joint_inflammation0.83997774
121MP0004043_abnormal_pH_regulation0.83190718
122MP0002998_abnormal_bone_remodeling0.82315723
123MP0005167_abnormal_blood-brain_barrier0.81824413
124MP0002909_abnormal_adrenal_gland0.80681589
125MP0010368_abnormal_lymphatic_system0.80375665
126MP0000538_abnormal_urinary_bladder0.79864660
127MP0002064_seizures0.78089049
128MP0010352_gastrointestinal_tract_polyps0.77683021
129MP0001270_distended_abdomen0.76994795
130MP0002295_abnormal_pulmonary_circulatio0.76355597
131MP0001968_abnormal_touch/_nociception0.75208211
132MP0003828_pulmonary_edema0.74482209
133MP0003122_maternal_imprinting0.72819541
134MP0000467_abnormal_esophagus_morphology0.72111315
135MP0000477_abnormal_intestine_morphology0.71973790
136MP0001879_abnormal_lymphatic_vessel0.71969023
137MP0005166_decreased_susceptibility_to0.71651573
138MP0002089_abnormal_postnatal_growth/wei0.71435018
139MP0010771_integument_phenotype0.70299834
140MP0004883_abnormal_blood_vessel0.69354664
141MP0009115_abnormal_fat_cell0.69102204
142MP0000767_abnormal_smooth_muscle0.69084375
143MP0003632_abnormal_nervous_system0.68558442
144MP0002796_impaired_skin_barrier0.67762665
145MP0001501_abnormal_sleep_pattern0.67577992
146MP0002098_abnormal_vibrissa_morphology0.66261496
147MP0003635_abnormal_synaptic_transmissio0.65786107
148MP0005595_abnormal_vascular_smooth0.65709077
149MP0001440_abnormal_grooming_behavior0.65073460
150MP0005360_urolithiasis0.64859198
151MP0003567_abnormal_fetal_cardiomyocyte0.64410928
152MP0003191_abnormal_cellular_cholesterol0.64088972
153MP0002136_abnormal_kidney_physiology0.63716249
154MP0003115_abnormal_respiratory_system0.62973927
155MP0002128_abnormal_blood_circulation0.61904599
156MP0001765_abnormal_ion_homeostasis0.60602175
157MP0005248_abnormal_Harderian_gland0.60220257

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)8.75549149
2Segmental peripheral demyelination/remyelination (HP:0003481)7.30727578
3Termporal pattern (HP:0011008)5.61477836
4Insidious onset (HP:0003587)5.61477836
5Impaired proprioception (HP:0010831)5.17478602
6Increased CSF protein (HP:0002922)4.53117164
7Abnormality of glutamine family amino acid metabolism (HP:0010902)4.32194000
8Action tremor (HP:0002345)4.26082769
9Foot dorsiflexor weakness (HP:0009027)4.00393644
10Atrophic scars (HP:0001075)3.90969639
11Right ventricular cardiomyopathy (HP:0011663)3.82423956
12Onion bulb formation (HP:0003383)3.76598482
13Increased connective tissue (HP:0009025)3.76435444
14Premature rupture of membranes (HP:0001788)3.73692973
15Abnormality of the foot musculature (HP:0001436)3.72606733
16Steppage gait (HP:0003376)3.71841257
17Muscle fiber splitting (HP:0003555)3.59181937
18Hyporeflexia of lower limbs (HP:0002600)3.49419995
19Upper limb muscle weakness (HP:0003484)3.42969047
20Hammertoe (HP:0001765)3.32059037
21Thin bony cortex (HP:0002753)3.30533754
22Ankle contracture (HP:0006466)3.25821827
23Protrusio acetabuli (HP:0003179)3.19041014
24Fragile skin (HP:0001030)3.15573183
25Type 1 muscle fiber predominance (HP:0003803)3.14768283
26Peripheral hypomyelination (HP:0007182)3.13409802
27Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.08801442
28Sudden death (HP:0001699)3.05089327
29Abnormality of the vocal cords (HP:0008777)3.03228085
30Ventricular tachycardia (HP:0004756)3.01477375
31Deep venous thrombosis (HP:0002625)2.99321500
32Upper limb amyotrophy (HP:0009129)2.96725994
33Distal upper limb amyotrophy (HP:0007149)2.96725994
34Malnutrition (HP:0004395)2.94016667
35Broad metatarsal (HP:0001783)2.91703164
36Hemorrhage of the eye (HP:0011885)2.90541202
37Systemic lupus erythematosus (HP:0002725)2.85722718
38Obstructive sleep apnea (HP:0002870)2.78693603
39Stridor (HP:0010307)2.78611399
40Neurofibrillary tangles (HP:0002185)2.78061842
41Abnormality of the calf musculature (HP:0001430)2.77834467
42Exercise-induced muscle cramps (HP:0003710)2.75811884
43Peripheral demyelination (HP:0011096)2.75662449
44Cervical subluxation (HP:0003308)2.75250026
45Mildly elevated creatine phosphokinase (HP:0008180)2.74218895
46Difficulty running (HP:0009046)2.72249161
47Complement deficiency (HP:0004431)2.70913529
48Aortic dissection (HP:0002647)2.67114250
49Flat acetabular roof (HP:0003180)2.66956452
50Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.66851836
51Decreased motor nerve conduction velocity (HP:0003431)2.63274541
52J-shaped sella turcica (HP:0002680)2.62357252
53Cerebral aneurysm (HP:0004944)2.61750792
54Bronchomalacia (HP:0002780)2.61716522
55Abnormality of complement system (HP:0005339)2.57844702
56Xanthomatosis (HP:0000991)2.56459534
57Postural tremor (HP:0002174)2.55792870
58Vertebral compression fractures (HP:0002953)2.55713453
59Mesangial abnormality (HP:0001966)2.54173662
60Increased variability in muscle fiber diameter (HP:0003557)2.54092824
61Difficulty climbing stairs (HP:0003551)2.53018634
62Glomerulonephritis (HP:0000099)2.40910760
63Spinal rigidity (HP:0003306)2.38946738
64EMG: myopathic abnormalities (HP:0003458)2.37929312
65Lipoatrophy (HP:0100578)2.36688165
66Abnormality of skeletal muscle fiber size (HP:0012084)2.35676572
67Bundle branch block (HP:0011710)2.33233682
68Bladder diverticulum (HP:0000015)2.30257111
69Ventricular fibrillation (HP:0001663)2.29828481
70Broad face (HP:0000283)2.29437555
71Progressive sensorineural hearing impairment (HP:0000408)2.29089261
72Abnormal pupillary function (HP:0007686)2.27921544
73Ankle clonus (HP:0011448)2.27212653
74Abnormality of carpal bone ossification (HP:0006257)2.24701776
75Calf muscle hypertrophy (HP:0008981)2.24680019
76Hyperactive renin-angiotensin system (HP:0000841)2.22334112
77Ulnar bowing (HP:0003031)2.22192131
78Distal lower limb muscle weakness (HP:0009053)2.22003934
79Aortic aneurysm (HP:0004942)2.21225856
80Shallow orbits (HP:0000586)2.18876994
81Abnormality of the Achilles tendon (HP:0005109)2.15865735
82Focal segmental glomerulosclerosis (HP:0000097)2.15441242
83Exercise-induced myalgia (HP:0003738)2.14211381
84Asymmetric septal hypertrophy (HP:0001670)2.13378310
85Myotonia (HP:0002486)2.12816760
86Cerebral inclusion bodies (HP:0100314)2.12436606
87Supranuclear gaze palsy (HP:0000605)2.11099995
88Achilles tendon contracture (HP:0001771)2.10944026
89Axonal loss (HP:0003447)2.09166191
90Lower limb amyotrophy (HP:0007210)2.08546026
91Hyperacusis (HP:0010780)2.07074738
92Atrial fibrillation (HP:0005110)2.06443745
93Hand muscle atrophy (HP:0009130)2.06374747
94Milia (HP:0001056)2.05579058
95Mitral regurgitation (HP:0001653)2.04776722
96Ileus (HP:0002595)2.04270136
97Syncope (HP:0001279)2.02647019
98Arterial tortuosity (HP:0005116)2.01669870
99Dilated cardiomyopathy (HP:0001644)2.01270209
100Hypobetalipoproteinemia (HP:0003563)2.00548249
101Muscle hypertrophy of the lower extremities (HP:0008968)2.00341175
102Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.99823461
103Confusion (HP:0001289)1.99178097
104Hypoplasia of the iris (HP:0007676)1.98018864
105Scapular winging (HP:0003691)1.97731881
106Alopecia of scalp (HP:0002293)1.96964684
107Abnormal ossification of hand bones (HP:0005921)1.96878455
108Prolonged QT interval (HP:0001657)1.96534817
109Lymphangioma (HP:0100764)1.96015140
110Ventricular arrhythmia (HP:0004308)1.95843489
111Skin nodule (HP:0200036)1.95258327
112Hyperparathyroidism (HP:0000843)1.94814913
113Muscle fiber inclusion bodies (HP:0100299)1.94576912
114Neonatal death (HP:0003811)1.93921496
115Primary atrial arrhythmia (HP:0001692)1.93904244
116Limb-girdle muscle atrophy (HP:0003797)1.93308365
117Gout (HP:0001997)1.92874437
118Coxa vara (HP:0002812)1.92705337
119Widely patent fontanelles and sutures (HP:0004492)1.92312478
120Hypomagnesemia (HP:0002917)1.92081915
121Urinary glycosaminoglycan excretion (HP:0003541)1.89004753
122Mucopolysacchariduria (HP:0008155)1.89004753
123Biconcave vertebral bodies (HP:0004586)1.87760226
124Abnormality of proline metabolism (HP:0010907)1.87676602
125Hydroxyprolinuria (HP:0003080)1.87676602
126Alacrima (HP:0000522)1.87484031
127Supraventricular arrhythmia (HP:0005115)1.87436619
128Distal arthrogryposis (HP:0005684)1.87435215
129Myoglobinuria (HP:0002913)1.86566550
130Growth hormone excess (HP:0000845)1.86209296
131Turricephaly (HP:0000262)1.85294640
132Pterygium (HP:0001059)1.84501794
133Soft skin (HP:0000977)1.84407646
134Gowers sign (HP:0003391)1.83991211
135Aplasia involving bones of the extremities (HP:0009825)1.83874318
136Aplasia involving bones of the upper limbs (HP:0009823)1.83874318
137Aplasia of the phalanges of the hand (HP:0009802)1.83874318
138Neonatal short-limb short stature (HP:0008921)1.83470126
139Supraventricular tachycardia (HP:0004755)1.83432075
140Abnormality of monocarboxylic acid metabolism (HP:0010996)1.83411511
141Hip contracture (HP:0003273)1.81799113
142Vascular tortuosity (HP:0004948)1.81776709
143Wide cranial sutures (HP:0010537)1.80369137
144Nephritis (HP:0000123)1.80209112
145Palpitations (HP:0001962)1.79728671
146Glomerulosclerosis (HP:0000096)1.79506132
147Abnormal atrioventricular conduction (HP:0005150)1.79103278
148Small epiphyses (HP:0010585)1.79068451
149Nuclear cataract (HP:0100018)1.78599266
150Distal lower limb amyotrophy (HP:0008944)1.78505460
151Aneurysm (HP:0002617)1.75839755
152Distal sensory impairment (HP:0002936)1.75676889
153Abnormality of chloride homeostasis (HP:0011422)1.75575931
154Akinesia (HP:0002304)1.75069134
155Round ear (HP:0100830)1.74911646
156Hypercholesterolemia (HP:0003124)1.74877604
157Joint stiffness (HP:0001387)1.74209025
158Abdominal distention (HP:0003270)1.73870594
159Mitral stenosis (HP:0001718)1.73474470
160Elbow flexion contracture (HP:0002987)1.71001823
161Mitral valve prolapse (HP:0001634)1.70980151
162Abnormality of polysaccharide metabolism (HP:0011012)1.70836115
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70836115
164Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70836115
165Fat malabsorption (HP:0002630)1.69856476
166Abnormal hand bone ossification (HP:0010660)1.67594432
167Wrist flexion contracture (HP:0001239)1.67567569
168Pigmentary retinal degeneration (HP:0001146)1.67429725
169Abnormality of magnesium homeostasis (HP:0004921)1.67418044
170Blue sclerae (HP:0000592)1.67011711
171Wormian bones (HP:0002645)1.66939332
172Hypolipoproteinemia (HP:0010981)1.65042633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.51937834
2TTN3.80347674
3TRIB33.43823268
4WNK42.88961036
5EPHB12.45750155
6EPHA22.26338823
7PKN22.21769901
8MYLK2.12514101
9RIPK12.11470730
10EPHB22.10662894
11LATS11.94191651
12MST1R1.90823755
13STK391.87858851
14DDR21.85045067
15PHKG21.83959723
16PHKG11.83959723
17FER1.71614906
18PAK41.65706475
19EPHA41.65163600
20DMPK1.61149304
21AKT31.60721141
22PDGFRA1.60572743
23PTK61.58733217
24NTRK31.57149340
25LRRK21.51624722
26MAP3K21.42988511
27MET1.41850752
28TGFBR21.38704470
29EPHA31.37794075
30KSR21.37576587
31PDK31.37372518
32PDK41.37372518
33DAPK21.36997132
34PRPF4B1.36901075
35PTK21.36328115
36LATS21.34711233
37NTRK11.34441562
38OBSCN1.32339607
39RET1.26540140
40ROCK11.26465416
41PRKG21.24838264
42SIK11.24458858
43TYRO31.20178484
44FGFR31.18969101
45MAP2K21.18933973
46MAPKAPK31.15740294
47MAP2K11.11384065
48TIE11.11252674
49PAK31.10492471
50MAP3K71.10114800
51PDK21.09153687
52ROCK21.08802175
53LIMK11.07439064
54ILK1.05236066
55SMG11.04146571
56PIK3CA1.03780961
57BMX1.03385298
58UHMK11.02890028
59WNK11.02480482
60MAP3K30.98663106
61PRKD20.98123444
62PRKD30.95321723
63ERN10.93853101
64FGFR40.92514645
65MUSK0.89067612
66NEK10.85078440
67CDC42BPA0.84663217
68PRKD10.84604101
69MAP2K30.84281813
70CAMK2B0.84166452
71ICK0.81514729
72MST40.77617441
73TRPM70.74419919
74IRAK30.74281961
75ERBB20.73923968
76STK38L0.73029030
77KDR0.72739018
78NEK60.70232683
79DYRK1B0.70180776
80SIK20.68438016
81STK380.67998521
82EEF2K0.67843975
83PAK20.67449215
84ARAF0.66983723
85GSK3A0.66942340
86MAP3K130.63554493
87PDK10.63542965
88MAP3K60.62836885
89NEK90.62268731
90MATK0.62216818
91OXSR10.61858480
92MARK10.61430948
93PTK2B0.61072037
94CAMK2D0.60875003
95FGFR20.59625499
96PDGFRB0.58544066
97NME10.58238641
98MAP2K60.58063088
99MAP3K110.57051651
100ZAP700.55886137
101FRK0.54865713
102MAP3K10.54076185
103ABL20.53806008
104CAMKK10.53555983
105MARK20.52914336
106CDK120.52657745
107RPS6KB20.52123873
108GRK50.51186880
109STK100.50600175
110IRAK10.49676993
111RPS6KL10.47180107
112RPS6KC10.47180107
113MAPK120.45900479
114PRKCE0.45078007
115MTOR0.44874468
116DAPK10.44130803
117RPS6KA20.43026165
118NTRK20.42927862
119HIPK20.41979868
120CAMK1D0.41071349
121MAPK110.40927620
122MAP3K90.40648433
123PRKCZ0.40169153
124NME20.39622480
125PAK60.37641201
126PDPK10.37080115
127DAPK30.36644894
128SRC0.34911883
129STK240.32173305
130MARK30.31965112
131CAMK2G0.31036454
132PRKAA10.29996341
133TESK10.29616248
134SGK4940.29257401
135SGK2230.29257401
136FGFR10.29065519
137AKT20.27706404
138MAP3K80.27354852
139MOS0.27263050

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.50676093
2ECM-receptor interaction_Homo sapiens_hsa045123.19430558
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.83790573
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.75209261
5Dilated cardiomyopathy_Homo sapiens_hsa054142.74984661
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.50305780
7Arginine biosynthesis_Homo sapiens_hsa002202.37273540
8Protein digestion and absorption_Homo sapiens_hsa049742.27144910
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09452749
10Focal adhesion_Homo sapiens_hsa045102.03697651
11Other glycan degradation_Homo sapiens_hsa005111.92330146
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89517165
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70678817
14Fatty acid degradation_Homo sapiens_hsa000711.66313478
15Tight junction_Homo sapiens_hsa045301.63763337
16Cardiac muscle contraction_Homo sapiens_hsa042601.54746043
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.54237627
18Viral myocarditis_Homo sapiens_hsa054161.50627165
19Amoebiasis_Homo sapiens_hsa051461.41299260
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37388015
21Propanoate metabolism_Homo sapiens_hsa006401.35500880
22Adherens junction_Homo sapiens_hsa045201.35205328
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33442792
24Complement and coagulation cascades_Homo sapiens_hsa046101.33172189
25Starch and sucrose metabolism_Homo sapiens_hsa005001.32566749
26Ovarian steroidogenesis_Homo sapiens_hsa049131.32138147
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31189175
28Small cell lung cancer_Homo sapiens_hsa052221.29786299
29Mineral absorption_Homo sapiens_hsa049781.28197920
30Fatty acid metabolism_Homo sapiens_hsa012121.25760204
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23337251
32Bile secretion_Homo sapiens_hsa049761.23308759
33Renin-angiotensin system_Homo sapiens_hsa046141.19505378
34Proteoglycans in cancer_Homo sapiens_hsa052051.15920576
35PPAR signaling pathway_Homo sapiens_hsa033201.15533292
36Vitamin B6 metabolism_Homo sapiens_hsa007501.15222412
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14441925
38Carbon metabolism_Homo sapiens_hsa012001.13470823
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12380944
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10202204
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.08582574
42Bladder cancer_Homo sapiens_hsa052191.08236115
43Gastric acid secretion_Homo sapiens_hsa049711.03652318
44Pyruvate metabolism_Homo sapiens_hsa006201.03028683
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.02812422
46Insulin secretion_Homo sapiens_hsa049111.01140929
47Prion diseases_Homo sapiens_hsa050201.00043136
48Fatty acid biosynthesis_Homo sapiens_hsa000611.00036394
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99665468
50Galactose metabolism_Homo sapiens_hsa000520.94011763
51Synaptic vesicle cycle_Homo sapiens_hsa047210.93670189
52Butanoate metabolism_Homo sapiens_hsa006500.91452069
53Glycerolipid metabolism_Homo sapiens_hsa005610.91302606
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89779073
55Fat digestion and absorption_Homo sapiens_hsa049750.88072729
56Sphingolipid metabolism_Homo sapiens_hsa006000.87672227
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87262897
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86627865
59Long-term potentiation_Homo sapiens_hsa047200.85850235
60ABC transporters_Homo sapiens_hsa020100.84193362
61Dorso-ventral axis formation_Homo sapiens_hsa043200.83286347
62Renin secretion_Homo sapiens_hsa049240.83083971
63Thyroid cancer_Homo sapiens_hsa052160.82145498
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.81701167
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79563040
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77832129
67Hippo signaling pathway_Homo sapiens_hsa043900.77192713
68Sulfur relay system_Homo sapiens_hsa041220.77117658
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77039139
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76323219
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.75116782
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75023140
73Insulin resistance_Homo sapiens_hsa049310.74090662
74Thyroid hormone synthesis_Homo sapiens_hsa049180.73595907
75Cocaine addiction_Homo sapiens_hsa050300.73511119
76Toxoplasmosis_Homo sapiens_hsa051450.73459870
77Insulin signaling pathway_Homo sapiens_hsa049100.72618327
78Notch signaling pathway_Homo sapiens_hsa043300.72153252
79Sulfur metabolism_Homo sapiens_hsa009200.71353522
80Glucagon signaling pathway_Homo sapiens_hsa049220.69975964
81Biosynthesis of amino acids_Homo sapiens_hsa012300.69952504
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68498942
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68077925
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66906589
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66817386
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66718882
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.66035852
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.65696384
89Alzheimers disease_Homo sapiens_hsa050100.65654301
90Amphetamine addiction_Homo sapiens_hsa050310.65607069
91Hedgehog signaling pathway_Homo sapiens_hsa043400.63386379
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63384233
93Tryptophan metabolism_Homo sapiens_hsa003800.62365366
94Endometrial cancer_Homo sapiens_hsa052130.61762962
95Fructose and mannose metabolism_Homo sapiens_hsa000510.60777755
96Histidine metabolism_Homo sapiens_hsa003400.60743971
97Melanoma_Homo sapiens_hsa052180.60133546
98Arginine and proline metabolism_Homo sapiens_hsa003300.59203667
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59176788
100Fatty acid elongation_Homo sapiens_hsa000620.58044118
101Inositol phosphate metabolism_Homo sapiens_hsa005620.56726042
102* Axon guidance_Homo sapiens_hsa043600.56572415
103Salivary secretion_Homo sapiens_hsa049700.56397689
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56122106
105Parkinsons disease_Homo sapiens_hsa050120.55825224
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55161183
107Melanogenesis_Homo sapiens_hsa049160.54811091
108Gap junction_Homo sapiens_hsa045400.54435173
109Vibrio cholerae infection_Homo sapiens_hsa051100.54264707
110VEGF signaling pathway_Homo sapiens_hsa043700.54072646
111beta-Alanine metabolism_Homo sapiens_hsa004100.53985435
112Pentose phosphate pathway_Homo sapiens_hsa000300.53983816
113Oxidative phosphorylation_Homo sapiens_hsa001900.53911405
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.53811517
115Estrogen signaling pathway_Homo sapiens_hsa049150.53244898
116Glutamatergic synapse_Homo sapiens_hsa047240.52865778
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52744479
118Chronic myeloid leukemia_Homo sapiens_hsa052200.52519703
119Rap1 signaling pathway_Homo sapiens_hsa040150.52332653
120Platelet activation_Homo sapiens_hsa046110.50939957
121Phenylalanine metabolism_Homo sapiens_hsa003600.50814704
122HIF-1 signaling pathway_Homo sapiens_hsa040660.50211786
123GnRH signaling pathway_Homo sapiens_hsa049120.50201609
124Tyrosine metabolism_Homo sapiens_hsa003500.49968743
125Endocytosis_Homo sapiens_hsa041440.49869505
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49572385
127ErbB signaling pathway_Homo sapiens_hsa040120.49464332
128Vitamin digestion and absorption_Homo sapiens_hsa049770.48916827
129Glioma_Homo sapiens_hsa052140.48524415
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48195073
131Choline metabolism in cancer_Homo sapiens_hsa052310.47724232
132Chemical carcinogenesis_Homo sapiens_hsa052040.45530329
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45261951
134N-Glycan biosynthesis_Homo sapiens_hsa005100.45212823
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44965638
136Pancreatic secretion_Homo sapiens_hsa049720.44919125
137AMPK signaling pathway_Homo sapiens_hsa041520.44788586
138Pathways in cancer_Homo sapiens_hsa052000.44770878
139Salmonella infection_Homo sapiens_hsa051320.43938494
140Basal cell carcinoma_Homo sapiens_hsa052170.43520614
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42500106
142Glutathione metabolism_Homo sapiens_hsa004800.42048149
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41135437

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