SEMA3E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of activin receptor signaling pathway (GO:0032926)7.44143983
2regulation of mesoderm development (GO:2000380)6.39319505
3nodal signaling pathway (GO:0038092)6.25835526
4sequestering of extracellular ligand from receptor (GO:0035581)5.83578669
5anterior/posterior axis specification, embryo (GO:0008595)5.79342879
6cell migration involved in gastrulation (GO:0042074)5.71323824
7regulation of activin receptor signaling pathway (GO:0032925)5.32239900
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.96642597
9signal transduction involved in regulation of gene expression (GO:0023019)4.84881244
10glutamate receptor signaling pathway (GO:0007215)4.64676665
11mitochondrial fragmentation involved in apoptotic process (GO:0043653)4.62032858
12vocalization behavior (GO:0071625)4.56949918
13L-ascorbic acid metabolic process (GO:0019852)4.55263083
14locomotory exploration behavior (GO:0035641)4.41011702
15kidney morphogenesis (GO:0060993)4.40677391
16protein localization to synapse (GO:0035418)4.32136838
17neuron recognition (GO:0008038)4.32104209
18neuron cell-cell adhesion (GO:0007158)4.17721127
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.15697774
20axonal fasciculation (GO:0007413)4.12026898
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.04987796
22branching involved in labyrinthine layer morphogenesis (GO:0060670)3.98543532
23exploration behavior (GO:0035640)3.95488852
24gamma-aminobutyric acid signaling pathway (GO:0007214)3.95317819
25regulation of glutamate receptor signaling pathway (GO:1900449)3.92759704
26neuron-neuron synaptic transmission (GO:0007270)3.92590078
27regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.87545293
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87476931
29regulation of short-term neuronal synaptic plasticity (GO:0048172)3.87141228
30regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.83783231
31anterior/posterior axis specification (GO:0009948)3.82939607
32synaptic transmission, glutamatergic (GO:0035249)3.81258906
33positive regulation of cardiac muscle cell proliferation (GO:0060045)3.80882867
34embryonic pattern specification (GO:0009880)3.79707561
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.78683995
36long-term synaptic potentiation (GO:0060291)3.77474034
37synaptic vesicle exocytosis (GO:0016079)3.70318843
38response to histamine (GO:0034776)3.64651634
39glomerular visceral epithelial cell development (GO:0072015)3.64293149
40positive regulation of cardiac muscle tissue growth (GO:0055023)3.62496727
41lactate metabolic process (GO:0006089)3.61681683
42embryonic camera-type eye development (GO:0031076)3.59795363
43platelet dense granule organization (GO:0060155)3.59201055
44negative regulation of keratinocyte proliferation (GO:0010839)3.59029523
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.54814325
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54079498
47genitalia morphogenesis (GO:0035112)3.53148131
48neuronal action potential propagation (GO:0019227)3.50617642
49L-serine transport (GO:0015825)3.49792210
50ephrin receptor signaling pathway (GO:0048013)3.47906586
51embryonic axis specification (GO:0000578)3.46456584
52regulation of acyl-CoA biosynthetic process (GO:0050812)3.45689638
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45514843
54regulation of dendritic spine morphogenesis (GO:0061001)3.44846301
55extracellular negative regulation of signal transduction (GO:1900116)3.39468673
56extracellular regulation of signal transduction (GO:1900115)3.39468673
57startle response (GO:0001964)3.39462492
58behavioral defense response (GO:0002209)3.37703451
59behavioral fear response (GO:0001662)3.37703451
60glomerular epithelial cell development (GO:0072310)3.36929198
61regulation of timing of cell differentiation (GO:0048505)3.35913301
62regulation of cofactor metabolic process (GO:0051193)3.35829429
63regulation of coenzyme metabolic process (GO:0051196)3.35829429
64cellular response to BMP stimulus (GO:0071773)3.34052792
65response to BMP (GO:0071772)3.34052792
66dendritic spine organization (GO:0097061)3.33454737
67positive regulation of synapse maturation (GO:0090129)3.33325390
68somite rostral/caudal axis specification (GO:0032525)3.31092152
69regulation of postsynaptic membrane potential (GO:0060078)3.30698007
70female gonad development (GO:0008585)3.29646783
71inner ear receptor cell development (GO:0060119)3.27102865
72positive regulation of gastrulation (GO:2000543)3.26509596
73long-term memory (GO:0007616)3.25937454
74postsynaptic membrane organization (GO:0001941)3.25841461
75activin receptor signaling pathway (GO:0032924)3.25537544
76positive regulation of heart growth (GO:0060421)3.23995758
77regulation of neuronal synaptic plasticity (GO:0048168)3.23719781
78regulation of synaptic plasticity (GO:0048167)3.23080616
79positive regulation of vesicle fusion (GO:0031340)3.19935357
80glutamate secretion (GO:0014047)3.19818959
81long term synaptic depression (GO:0060292)3.17845584
82primitive streak formation (GO:0090009)3.15446850
83dendritic spine morphogenesis (GO:0060997)3.15412960
84cochlea development (GO:0090102)3.14811291
85regulation of synaptic vesicle exocytosis (GO:2000300)3.14717213
86positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.14049890
87fear response (GO:0042596)3.12578588
88protein localization to cilium (GO:0061512)3.10667743
89presynaptic membrane assembly (GO:0097105)3.10015288
90transmission of nerve impulse (GO:0019226)3.08821882
91regulation of development, heterochronic (GO:0040034)3.08742634
92innervation (GO:0060384)3.08697496
93dopamine biosynthetic process (GO:0042416)3.08169952
94synaptic transmission, dopaminergic (GO:0001963)3.05137781
95protein autoprocessing (GO:0016540)3.01989691
96response to pheromone (GO:0019236)3.01123496
97otic vesicle formation (GO:0030916)2.98140429
98behavioral response to cocaine (GO:0048148)2.97746777
99G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.95475483
100positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.95153014
101synaptic vesicle docking involved in exocytosis (GO:0016081)2.94767920
102neurotransmitter-gated ion channel clustering (GO:0072578)2.92627071
103positive regulation of neurotransmitter secretion (GO:0001956)2.92401623
104synaptic vesicle endocytosis (GO:0048488)2.92052993
105keratinocyte development (GO:0003334)2.91953472
106regulation of sulfur metabolic process (GO:0042762)2.91805254
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.91715869
108regulation of gastrulation (GO:0010470)2.91150853
109SMAD protein signal transduction (GO:0060395)2.91045680
110regulation of vesicle fusion (GO:0031338)2.90817886
111Leydig cell differentiation (GO:0033327)2.90660146
112regulation of dendritic spine development (GO:0060998)2.90118465
113positive regulation of synapse assembly (GO:0051965)2.89776001
114regulation of synaptic transmission, glutamatergic (GO:0051966)2.87322263
115presynaptic membrane organization (GO:0097090)2.86649190
116learning (GO:0007612)2.86470639
117regulation of synaptic vesicle transport (GO:1902803)2.86029371
118regulation of glutamate secretion (GO:0014048)2.85205343
119regulation of axon extension involved in axon guidance (GO:0048841)2.84749457
120regulation of axon guidance (GO:1902667)2.84538848
121dorsal/ventral axis specification (GO:0009950)2.82577196
122glycosphingolipid biosynthetic process (GO:0006688)2.82468331
123regulation of neuron projection regeneration (GO:0070570)2.81398926
124regulation of axon regeneration (GO:0048679)2.81398926
125regulation of synapse maturation (GO:0090128)2.81326254
126regulation of female receptivity (GO:0045924)2.80758200
127negative regulation of transcription regulatory region DNA binding (GO:2000678)2.79992607
128regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.79590680
129glomerular basement membrane development (GO:0032836)2.79436082
130vesicle transport along microtubule (GO:0047496)2.79067083
131detection of calcium ion (GO:0005513)2.77305969
132serotonin receptor signaling pathway (GO:0007210)2.76747607
133gastrulation (GO:0007369)2.76389221
134positive regulation of cardiac muscle tissue development (GO:0055025)2.76036596
135serine transport (GO:0032329)2.74972634
136regulation of hexokinase activity (GO:1903299)2.74394301
137regulation of glucokinase activity (GO:0033131)2.74394301
138negative regulation of execution phase of apoptosis (GO:1900118)2.73922587
139neuron remodeling (GO:0016322)2.73738971
140negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72665388
141axis specification (GO:0009798)2.72398933
142negative regulation of androgen receptor signaling pathway (GO:0060766)2.72298343
143regulation of synapse assembly (GO:0051963)2.72090350
144peptidyl-cysteine modification (GO:0018198)2.71613216
145regulation of cardiac muscle cell proliferation (GO:0060043)2.71508682
146chemosensory behavior (GO:0007635)2.70408056
147regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.68212714
148membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68172978
149regulation of keratinocyte proliferation (GO:0010837)2.66710701
150proline transport (GO:0015824)2.66473585
151regulation of synapse organization (GO:0050807)2.65927930
152positive regulation of cardiac muscle cell differentiation (GO:2000727)2.65430008
153regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64250046
154nonmotile primary cilium assembly (GO:0035058)2.63282866
155mitochondrial fission (GO:0000266)2.63141839
156cardiac right ventricle morphogenesis (GO:0003215)2.62546952
157layer formation in cerebral cortex (GO:0021819)2.57663140
158negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.57596573
159cellular potassium ion homeostasis (GO:0030007)2.57021576
160positive regulation of fibroblast migration (GO:0010763)2.56750420
161axon extension (GO:0048675)2.56363103
162female mating behavior (GO:0060180)2.56081164
163membrane depolarization (GO:0051899)2.56036475
164neurotransmitter secretion (GO:0007269)2.53800796
165estrogen metabolic process (GO:0008210)2.52923628
166memory (GO:0007613)2.52402524
167learning or memory (GO:0007611)2.52045705
168positive regulation of membrane potential (GO:0045838)2.51632034
169associative learning (GO:0008306)2.51428644
170atrial cardiac muscle cell action potential (GO:0086014)2.48831554
171digestive tract morphogenesis (GO:0048546)2.47998237
172limb bud formation (GO:0060174)2.47384448
173respiratory chain complex IV assembly (GO:0008535)2.46214139
174branched-chain amino acid catabolic process (GO:0009083)2.44374070
175signal peptide processing (GO:0006465)2.42941917
176phospholipid scrambling (GO:0017121)2.42298502
177glycerophospholipid catabolic process (GO:0046475)2.41470746
178multicellular organismal aging (GO:0010259)2.41077184
179prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.39240352
180ureteric bud development (GO:0001657)2.38394516
181regulation of tight junction assembly (GO:2000810)2.34464940
182cellular ketone body metabolic process (GO:0046950)2.34299282
183DNA double-strand break processing (GO:0000729)2.29897878
184regulation of neurotransmitter uptake (GO:0051580)2.29874133
185endoderm formation (GO:0001706)2.29147283
186regulation of stem cell maintenance (GO:2000036)2.27357544
187melanosome transport (GO:0032402)2.26988984
188establishment of melanosome localization (GO:0032401)2.26605850
189auditory receptor cell differentiation (GO:0042491)2.26148252
190embryonic foregut morphogenesis (GO:0048617)2.25830423
191DNA replication checkpoint (GO:0000076)2.24428218
192protein K6-linked ubiquitination (GO:0085020)2.23640846
193regulation of cardioblast differentiation (GO:0051890)2.23131852
194positive regulation of histone H3-K4 methylation (GO:0051571)2.21328093
195forebrain neuron differentiation (GO:0021879)2.20342049
196positive regulation of respiratory burst (GO:0060267)2.19233870
197S-adenosylmethionine metabolic process (GO:0046500)2.16764322
198regulation of cardiac muscle tissue growth (GO:0055021)2.15791657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67246350
2GBX2_23144817_ChIP-Seq_PC3_Human4.01096021
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.78075509
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03237715
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94295435
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93478286
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73889780
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.72271840
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55967245
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55967245
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47308180
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46870226
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.45305651
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37924456
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.34640988
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.31421616
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24478649
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08697424
19TAF15_26573619_Chip-Seq_HEK293_Human2.00535450
20* SMAD4_21741376_ChIP-Seq_HESCs_Human1.99956710
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.98922964
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96798393
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91492225
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88644807
25* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83564743
26AR_21572438_ChIP-Seq_LNCaP_Human1.83477112
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.82664200
28SMAD4_21799915_ChIP-Seq_A2780_Human1.82495516
29TP53_16413492_ChIP-PET_HCT116_Human1.79889764
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79138795
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78595269
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.78445274
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77880003
34* P300_19829295_ChIP-Seq_ESCs_Human1.76499654
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75724046
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75322425
37* REST_21632747_ChIP-Seq_MESCs_Mouse1.73012934
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.71961464
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70160527
40* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69074323
41* FUS_26573619_Chip-Seq_HEK293_Human1.68767152
42* RARB_27405468_Chip-Seq_BRAIN_Mouse1.68723847
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66718236
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65993546
45DROSHA_22980978_ChIP-Seq_HELA_Human1.63878822
46IGF1R_20145208_ChIP-Seq_DFB_Human1.63817495
47* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63555405
48* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63046185
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62543799
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62543799
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62543799
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62321387
53* TP53_18474530_ChIP-ChIP_U2OS_Human1.58425546
54* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58346997
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56182881
56* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53864920
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.53808673
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53391963
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52882194
60* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52654772
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.52131999
62ZNF274_21170338_ChIP-Seq_K562_Hela1.50958474
63* SMAD3_21741376_ChIP-Seq_EPCs_Human1.50753985
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.47014667
65* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44249654
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43261355
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.43114237
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.40098917
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40038067
70AHR_22903824_ChIP-Seq_MCF-7_Human1.39973018
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39581765
72* AR_25329375_ChIP-Seq_VCAP_Human1.38715611
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32884397
74* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32262926
75* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32168052
76* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31825657
77* TCF4_22108803_ChIP-Seq_LS180_Human1.31713068
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29274130
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28735537
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.27586118
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.26557908
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25969473
83CBP_20019798_ChIP-Seq_JUKART_Human1.25969473
84EOMES_21245162_ChIP-Seq_HESCs_Human1.25097666
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24822803
86SOX2_19829295_ChIP-Seq_ESCs_Human1.24742454
87NANOG_19829295_ChIP-Seq_ESCs_Human1.24742454
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24352023
89STAT3_23295773_ChIP-Seq_U87_Human1.23995655
90* TP53_22573176_ChIP-Seq_HFKS_Human1.23081746
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.22224278
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.22167350
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.19572119
94P53_22387025_ChIP-Seq_ESCs_Mouse1.19145668
95* SMAD3_21741376_ChIP-Seq_HESCs_Human1.18969360
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.18568099
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18435964
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18128968
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.17628826
100JUN_21703547_ChIP-Seq_K562_Human1.17517384
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.16674373
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15994093
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15824854
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15560292
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15536886
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15369855
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15160236
108* RUNX2_22187159_ChIP-Seq_PCA_Human1.14941012
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.14867055
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14604043
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14181060
112RNF2_27304074_Chip-Seq_NSC_Mouse1.14125930
113CDX2_22108803_ChIP-Seq_LS180_Human1.13775313
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13281094
115* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12962517
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.12681795
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.12402261
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.12262560
119VDR_22108803_ChIP-Seq_LS180_Human1.12067535
120RXR_22108803_ChIP-Seq_LS180_Human1.12051472
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11898983
122* TCF4_23295773_ChIP-Seq_U87_Human1.11808075
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.11462046
124STAT3_18555785_Chip-Seq_ESCs_Mouse1.11412460
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11280288
126* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11245176
127GABP_17652178_ChIP-ChIP_JURKAT_Human1.11117087
128KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11034973
129CMYC_18555785_Chip-Seq_ESCs_Mouse1.10460588
130HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10439375
131YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10393265
132EST1_17652178_ChIP-ChIP_JURKAT_Human1.09983960
133* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09587430
134* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09587430
135GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09481409
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09132316
137AR_19668381_ChIP-Seq_PC3_Human1.08825987
138* BCAT_22108803_ChIP-Seq_LS180_Human1.08218504
139ESR1_20079471_ChIP-ChIP_T-47D_Human1.07343371
140* ER_23166858_ChIP-Seq_MCF-7_Human1.05956072
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05763888
142TAL1_26923725_Chip-Seq_HPCs_Mouse1.05762774
143CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05630659
144FLI1_21867929_ChIP-Seq_TH2_Mouse1.04193955
145* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03990696
146P300_18555785_Chip-Seq_ESCs_Mouse1.02794436
147TCF4_18268006_ChIP-ChIP_LS174T_Human1.01888918
148EWS_26573619_Chip-Seq_HEK293_Human1.01356738
149HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99712901
150TP53_20018659_ChIP-ChIP_R1E_Mouse0.97987429
151* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97508559
152E2F1_18555785_Chip-Seq_ESCs_Mouse0.97490577
153BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97123996

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.81939120
2MP0003890_abnormal_embryonic-extraembry5.66636115
3MP0003880_abnormal_central_pattern5.21207468
4MP0004133_heterotaxia3.91200981
5MP0003635_abnormal_synaptic_transmissio3.64187572
6MP0008004_abnormal_stomach_pH3.47455069
7MP0009745_abnormal_behavioral_response3.13751126
8MP0002063_abnormal_learning/memory/cond3.12212936
9MP0004270_analgesia3.05194864
10MP0005623_abnormal_meninges_morphology2.61565899
11MP0002572_abnormal_emotion/affect_behav2.57591398
12MP0002064_seizures2.55418862
13MP0001968_abnormal_touch/_nociception2.47175459
14MP0010030_abnormal_orbit_morphology2.41174676
15MP0002736_abnormal_nociception_after2.32081603
16MP0001501_abnormal_sleep_pattern2.23814586
17MP0002735_abnormal_chemical_nociception2.21768151
18MP0001486_abnormal_startle_reflex2.14818108
19MP0001188_hyperpigmentation2.14323645
20MP0001440_abnormal_grooming_behavior2.13811664
21MP0002272_abnormal_nervous_system2.12137104
22MP0009780_abnormal_chondrocyte_physiolo2.07446767
23MP0009046_muscle_twitch1.96394737
24MP0004264_abnormal_extraembryonic_tissu1.95729906
25MP0002102_abnormal_ear_morphology1.93328204
26MP0000778_abnormal_nervous_system1.92006273
27MP0005379_endocrine/exocrine_gland_phen1.89640977
28MP0002163_abnormal_gland_morphology1.87787847
29MP0003329_amyloid_beta_deposits1.79830990
30MP0003195_calcinosis1.77034506
31MP0002734_abnormal_mechanical_nocicepti1.76095971
32MP0000372_irregular_coat_pigmentation1.74720712
33* MP0002184_abnormal_innervation1.74171637
34MP0003787_abnormal_imprinting1.69893715
35MP0000537_abnormal_urethra_morphology1.67692627
36MP0005248_abnormal_Harderian_gland1.61111024
37MP0002822_catalepsy1.60239953
38MP0006072_abnormal_retinal_apoptosis1.60100866
39MP0002938_white_spotting1.54397498
40MP0002067_abnormal_sensory_capabilities1.51422181
41MP0004272_abnormal_basement_membrane1.43281795
42MP0002733_abnormal_thermal_nociception1.40765347
43MP0001529_abnormal_vocalization1.38285299
44MP0001970_abnormal_pain_threshold1.35582782
45MP0000647_abnormal_sebaceous_gland1.34928713
46MP0002234_abnormal_pharynx_morphology1.34438520
47MP0008995_early_reproductive_senescence1.32873042
48MP0002277_abnormal_respiratory_mucosa1.31940791
49MP0006054_spinal_hemorrhage1.30048095
50MP0002557_abnormal_social/conspecific_i1.28847884
51MP0008872_abnormal_physiological_respon1.28558977
52MP0005551_abnormal_eye_electrophysiolog1.26765142
53MP0004484_altered_response_of1.25175912
54MP0003136_yellow_coat_color1.22480968
55MP0000013_abnormal_adipose_tissue1.21642181
56MP0001177_atelectasis1.21393151
57MP0005084_abnormal_gallbladder_morpholo1.20113411
58MP0003137_abnormal_impulse_conducting1.18868529
59MP0005645_abnormal_hypothalamus_physiol1.17145461
60MP0010386_abnormal_urinary_bladder1.16984680
61MP0002909_abnormal_adrenal_gland1.16287286
62MP0006276_abnormal_autonomic_nervous1.14768648
63MP0004811_abnormal_neuron_physiology1.14460973
64* MP0002882_abnormal_neuron_morphology1.13445376
65MP0004858_abnormal_nervous_system1.13045566
66MP0002837_dystrophic_cardiac_calcinosis1.12825309
67MP0004147_increased_porphyrin_level1.11881230
68MP0005253_abnormal_eye_physiology1.11635871
69MP0001299_abnormal_eye_distance/1.10337669
70MP0000462_abnormal_digestive_system1.09494956
71MP0004885_abnormal_endolymph1.08627544
72MP0003941_abnormal_skin_development1.08140682
73MP0008877_abnormal_DNA_methylation1.07114963
74MP0001346_abnormal_lacrimal_gland1.07036692
75MP0004924_abnormal_behavior1.06975347
76MP0005386_behavior/neurological_phenoty1.06975347
77MP0002066_abnormal_motor_capabilities/c1.06590127
78* MP0000955_abnormal_spinal_cord1.04993670
79MP0000427_abnormal_hair_cycle1.04717936
80MP0009379_abnormal_foot_pigmentation1.02176472
81MP0005409_darkened_coat_color0.99994678
82MP0003879_abnormal_hair_cell0.99562565
83MP0002090_abnormal_vision0.99440990
84MP0002152_abnormal_brain_morphology0.96813053
85MP0003283_abnormal_digestive_organ0.96575027
86MP0000631_abnormal_neuroendocrine_gland0.95431442
87MP0001984_abnormal_olfaction0.95383717
88MP0004019_abnormal_vitamin_homeostasis0.94865915
89MP0000639_abnormal_adrenal_gland0.94259218
90MP0001944_abnormal_pancreas_morphology0.94158982
91MP0005423_abnormal_somatic_nervous0.94033149
92MP0005171_absent_coat_pigmentation0.92378296
93MP0003091_abnormal_cell_migration0.91323375
94MP0005187_abnormal_penis_morphology0.91060586
95MP0008569_lethality_at_weaning0.90629227
96MP0003122_maternal_imprinting0.90607072
97MP0005499_abnormal_olfactory_system0.89437345
98MP0005394_taste/olfaction_phenotype0.89437345
99MP0000678_abnormal_parathyroid_gland0.85736545
100MP0000538_abnormal_urinary_bladder0.85081837
101MP0004215_abnormal_myocardial_fiber0.84990352
102MP0010234_abnormal_vibrissa_follicle0.83628506
103MP0001664_abnormal_digestion0.83602736
104MP0008058_abnormal_DNA_repair0.83583974
105MP0004085_abnormal_heartbeat0.83405944
106MP0003936_abnormal_reproductive_system0.82709796
107MP0003938_abnormal_ear_development0.82605471
108MP0003385_abnormal_body_wall0.82018032
109MP0005367_renal/urinary_system_phenotyp0.81874280
110MP0000516_abnormal_urinary_system0.81874280
111MP0000534_abnormal_ureter_morphology0.79872703
112MP0001963_abnormal_hearing_physiology0.79755374
113MP0004742_abnormal_vestibular_system0.79196641
114MP0003631_nervous_system_phenotype0.78912004
115MP0000428_abnormal_craniofacial_morphol0.78529590
116MP0009697_abnormal_copulation0.78522276
117MP0003632_abnormal_nervous_system0.76164766
118MP0005636_abnormal_mineral_homeostasis0.75945487
119MP0000026_abnormal_inner_ear0.75715356
120MP0002254_reproductive_system_inflammat0.74880079
121MP0003633_abnormal_nervous_system0.74784137
122MP0002132_abnormal_respiratory_system0.74554083
123MP0003755_abnormal_palate_morphology0.74504009
124MP0001905_abnormal_dopamine_level0.74312874
125MP0002233_abnormal_nose_morphology0.73521568
126MP0010329_abnormal_lipoprotein_level0.72785533
127MP0004145_abnormal_muscle_electrophysio0.72773731
128MP0003567_abnormal_fetal_cardiomyocyte0.72089357
129MP0001756_abnormal_urination0.71861323
130MP0006292_abnormal_olfactory_placode0.71801398
131MP0008057_abnormal_DNA_replication0.71627189
132MP0003786_premature_aging0.71457464
133* MP0002752_abnormal_somatic_nervous0.70414673
134MP0003861_abnormal_nervous_system0.70400622
135MP0000762_abnormal_tongue_morphology0.69815386
136MP0001958_emphysema0.69273619
137MP0002751_abnormal_autonomic_nervous0.69177711
138MP0004510_myositis0.69026842
139MP0002069_abnormal_eating/drinking_beha0.68794192
140MP0002133_abnormal_respiratory_system0.68784344
141MP0005388_respiratory_system_phenotype0.68784344
142MP0001943_abnormal_respiration0.68485172
143MP0003119_abnormal_digestive_system0.68353618
144MP0002295_abnormal_pulmonary_circulatio0.68352289
145MP0000613_abnormal_salivary_gland0.68342806
146MP0005646_abnormal_pituitary_gland0.67484941
147MP0000470_abnormal_stomach_morphology0.66975063
148MP0003937_abnormal_limbs/digits/tail_de0.66686781
149MP0008789_abnormal_olfactory_epithelium0.65841946
150MP0005595_abnormal_vascular_smooth0.65464538
151MP0010678_abnormal_skin_adnexa0.65011815
152MP0001485_abnormal_pinna_reflex0.63120658

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.08092065
2Atonic seizures (HP:0010819)5.24661368
3Focal seizures (HP:0007359)4.83865211
4Abdominal situs inversus (HP:0003363)4.66681995
5Abnormality of abdominal situs (HP:0011620)4.66681995
6Febrile seizures (HP:0002373)4.63279390
7Epileptic encephalopathy (HP:0200134)4.06887807
8Absence seizures (HP:0002121)3.99211028
9Cerebral inclusion bodies (HP:0100314)3.94776989
10Hyperventilation (HP:0002883)3.69121306
11Myokymia (HP:0002411)3.61383383
12Dialeptic seizures (HP:0011146)3.57052720
13Visual hallucinations (HP:0002367)3.49204047
14Bifid tongue (HP:0010297)3.34036637
15Fetal akinesia sequence (HP:0001989)3.30847043
16Broad-based gait (HP:0002136)3.09500818
17Progressive cerebellar ataxia (HP:0002073)3.08595890
18Generalized tonic-clonic seizures (HP:0002069)3.06764130
19Neurofibrillary tangles (HP:0002185)2.93753400
20Inability to walk (HP:0002540)2.90984786
21Absent speech (HP:0001344)2.90190702
22Anterior segment dysgenesis (HP:0007700)2.89811628
23Hydroureter (HP:0000072)2.89522392
24Type II lissencephaly (HP:0007260)2.86870666
25Abnormal ventriculo-arterial connection (HP:0011563)2.86736261
26Transposition of the great arteries (HP:0001669)2.86736261
27Abnormal connection of the cardiac segments (HP:0011545)2.86736261
28Amblyopia (HP:0000646)2.85905637
29Excessive salivation (HP:0003781)2.72959285
30Drooling (HP:0002307)2.72959285
31Medial flaring of the eyebrow (HP:0010747)2.67481078
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66474782
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65320622
34Abnormality of alanine metabolism (HP:0010916)2.65320622
35Hyperalaninemia (HP:0003348)2.65320622
36Action tremor (HP:0002345)2.64046995
37Abnormal pancreas size (HP:0012094)2.55257206
38Vaginal atresia (HP:0000148)2.53829129
39Pancreatic cysts (HP:0001737)2.53676080
40Gait imbalance (HP:0002141)2.51160558
41Arterial tortuosity (HP:0005116)2.50904304
42Hypothermia (HP:0002045)2.50414943
43Genital tract atresia (HP:0001827)2.48142685
44Dysdiadochokinesis (HP:0002075)2.47572630
45Distal lower limb amyotrophy (HP:0008944)2.46346931
46Zonular cataract (HP:0010920)2.45928276
47Abnormality of the fetal cardiovascular system (HP:0010948)2.45506453
48Abnormal umbilical cord blood vessels (HP:0011403)2.45506453
49Single umbilical artery (HP:0001195)2.45506453
50Preaxial foot polydactyly (HP:0001841)2.44432899
51Supranuclear gaze palsy (HP:0000605)2.39933291
52Abnormality of midbrain morphology (HP:0002418)2.39656649
53Molar tooth sign on MRI (HP:0002419)2.39656649
54Exotropia (HP:0000577)2.38494260
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.37510300
56Amelogenesis imperfecta (HP:0000705)2.37424188
57Congenital primary aphakia (HP:0007707)2.37127460
58Optic nerve hypoplasia (HP:0000609)2.35836398
59Hepatoblastoma (HP:0002884)2.35556522
60Testicular atrophy (HP:0000029)2.32641684
61Limb dystonia (HP:0002451)2.31920477
62Lower limb amyotrophy (HP:0007210)2.30196454
63Choroideremia (HP:0001139)2.30117307
64Focal segmental glomerulosclerosis (HP:0000097)2.28367653
65Vascular tortuosity (HP:0004948)2.27694620
66Methylmalonic acidemia (HP:0002912)2.25724122
67Heterochromia iridis (HP:0001100)2.25604793
68Concave nail (HP:0001598)2.23550744
69Abnormality of binocular vision (HP:0011514)2.22990096
70Diplopia (HP:0000651)2.22990096
71Nephrogenic diabetes insipidus (HP:0009806)2.18758900
72Abnormality of the dental pulp (HP:0006479)2.17312385
73Dysmetria (HP:0001310)2.16098949
74Truncal ataxia (HP:0002078)2.14255346
75Abnormality of salivation (HP:0100755)2.12244427
76Gaze-evoked nystagmus (HP:0000640)2.11497453
77Palpebral edema (HP:0100540)2.09348446
78Rapidly progressive (HP:0003678)2.09123122
79Epileptiform EEG discharges (HP:0011182)2.08572302
80True hermaphroditism (HP:0010459)2.08303674
81Aplasia of the musculature (HP:0100854)2.07812325
82Gonadal dysgenesis (HP:0000133)2.07098996
83Abnormality of the nasal septum (HP:0000419)2.07026361
84Impaired smooth pursuit (HP:0007772)2.06843389
85* Intestinal atresia (HP:0011100)2.06580647
86Abnormality of permanent molar morphology (HP:0011071)2.05569639
87Abnormality of the dental root (HP:0006486)2.05569639
88Taurodontia (HP:0000679)2.05569639
89Widely spaced teeth (HP:0000687)2.04894526
90Septo-optic dysplasia (HP:0100842)2.03127800
91Absent/shortened dynein arms (HP:0200106)2.02997550
92Dynein arm defect of respiratory motile cilia (HP:0012255)2.02997550
93Protruding tongue (HP:0010808)2.02916194
94* Double outlet right ventricle (HP:0001719)2.02700340
95* Congenital malformation of the right heart (HP:0011723)2.02700340
96Anxiety (HP:0000739)2.01853839
97Hypoplastic labia majora (HP:0000059)2.00668860
98Short middle phalanx of the 5th finger (HP:0004220)1.99878141
99Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.99738116
100Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99663851
101Pancreatic fibrosis (HP:0100732)1.99114057
102Large for gestational age (HP:0001520)1.97356323
103Facial diplegia (HP:0001349)1.96075292
104Microretrognathia (HP:0000308)1.95042327
105* Labial hypoplasia (HP:0000066)1.94034528
106Ankyloglossia (HP:0010296)1.93846106
107Termporal pattern (HP:0011008)1.92876416
108Insidious onset (HP:0003587)1.92876416
109Aplasia/Hypoplasia of the uvula (HP:0010293)1.92246774
110Delusions (HP:0000746)1.91341372
111Akinesia (HP:0002304)1.91041846
112Hyperactive renin-angiotensin system (HP:0000841)1.90949486
113Abnormality of molar (HP:0011077)1.90673442
114Abnormality of molar morphology (HP:0011070)1.90673442
115Acute necrotizing encephalopathy (HP:0006965)1.90367981
116Short hallux (HP:0010109)1.90147138
117Acute encephalopathy (HP:0006846)1.89924956
118Myelomeningocele (HP:0002475)1.89807613
119Hypoplastic nipples (HP:0002557)1.88563166
120Lissencephaly (HP:0001339)1.88516860
121Retinal dysplasia (HP:0007973)1.88439496
122Aplasia involving bones of the extremities (HP:0009825)1.88334898
123Aplasia involving bones of the upper limbs (HP:0009823)1.88334898
124Aplasia of the phalanges of the hand (HP:0009802)1.88334898
125Depression (HP:0000716)1.87766439
126Poor eye contact (HP:0000817)1.86999621
127Abnormal rod and cone electroretinograms (HP:0008323)1.86956269
128Popliteal pterygium (HP:0009756)1.86938277
129Thickened helices (HP:0000391)1.86354569
130Abnormal ciliary motility (HP:0012262)1.85984674
131Abnormality of vitamin B metabolism (HP:0004340)1.85520893
132Hypoglycemic coma (HP:0001325)1.85324939
133Scanning speech (HP:0002168)1.84432150
134Progressive macrocephaly (HP:0004481)1.82662353
135Hemiparesis (HP:0001269)1.82026261
136Stereotypic behavior (HP:0000733)1.81999685
137Abnormality of the labia majora (HP:0012881)1.81281896
138Bony spicule pigmentary retinopathy (HP:0007737)1.81089091
139Aplasia/Hypoplasia of the tibia (HP:0005772)1.80742200
140Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80045075
141Aplasia/hypoplasia of the uterus (HP:0008684)1.79990020
142Gastroesophageal reflux (HP:0002020)1.79426388
143Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.79382349
144Late onset (HP:0003584)1.79280561
145Nephronophthisis (HP:0000090)1.78748168
146Aplasia/hypoplasia of the humerus (HP:0006507)1.77450709
147Aplasia/Hypoplasia of the hallux (HP:0008362)1.77348980
148Absent eyebrow (HP:0002223)1.77063243
149Hyperinsulinemic hypoglycemia (HP:0000825)1.75961849
150Abnormality of oral frenula (HP:0000190)1.75433975
151Resting tremor (HP:0002322)1.75392511
152Glomerulosclerosis (HP:0000096)1.74908896
153Hypoalphalipoproteinemia (HP:0003233)1.73665732
154Occipital encephalocele (HP:0002085)1.73460099
155Impaired vibration sensation in the lower limbs (HP:0002166)1.72975439
156Stage 5 chronic kidney disease (HP:0003774)1.72970741
157Blue irides (HP:0000635)1.72851034
158Attenuation of retinal blood vessels (HP:0007843)1.71874672
159Absent frontal sinuses (HP:0002688)1.70119119
160Decreased circulating renin level (HP:0003351)1.70069918
161Fragile nails (HP:0001808)1.69524350
162Tongue fasciculations (HP:0001308)1.68611215
163* Hypoplastic female external genitalia (HP:0012815)1.67951284
164Short humerus (HP:0005792)1.67035957
165Methylmalonic aciduria (HP:0012120)1.66982413
166Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.66090125
167Lower limb asymmetry (HP:0100559)1.65608882
168EEG with generalized epileptiform discharges (HP:0011198)1.65410982
169Poor coordination (HP:0002370)1.65277992
170Hypoglycemic seizures (HP:0002173)1.65225677
171Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.65144525
172Right ventricular cardiomyopathy (HP:0011663)1.64228619
173Stenosis of the external auditory canal (HP:0000402)1.63805503
174Pterygium (HP:0001059)1.62602632
175Bronchomalacia (HP:0002780)1.62535440
176Abnormality of the labia minora (HP:0012880)1.62386114
177Hyperthyroidism (HP:0000836)1.61915972
178Hyperkalemia (HP:0002153)1.61624782
179Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.61428332
180Genetic anticipation (HP:0003743)1.60535297
181Incomplete penetrance (HP:0003829)1.60369288
182Short tibia (HP:0005736)1.59941859
183Abnormal social behavior (HP:0012433)1.59784676
184Impaired social interactions (HP:0000735)1.59784676
185Aplasia/Hypoplasia of the tongue (HP:0010295)1.59222141
186Nuclear cataract (HP:0100018)1.56542960
187Abnormal eating behavior (HP:0100738)1.54580381
188Complete atrioventricular canal defect (HP:0001674)1.54237577
189Buphthalmos (HP:0000557)1.53769700
190Shallow orbits (HP:0000586)1.53077956
191Hypodontia (HP:0000668)1.52917480
192Progressive sensorineural hearing impairment (HP:0000408)1.52443571
193Abnormality of ocular smooth pursuit (HP:0000617)1.52120833
194Progressive inability to walk (HP:0002505)1.51547370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.85847079
2NTRK34.43220840
3RIPK43.98036312
4ACVR1B3.11939847
5PBK2.90080558
6CASK2.89577849
7BMPR1B2.82422170
8PLK22.76751126
9TRIM282.73180225
10MAP3K42.60650507
11MAP3K122.53922719
12MAP2K72.32004719
13MAP4K22.24878067
14WNK32.24746215
15GRK12.20494552
16MINK12.12422100
17PTK2B2.03343638
18PNCK2.00574426
19BMPR21.99550119
20EPHB21.90535113
21STK161.85339768
22FGR1.83147583
23NTRK11.80445986
24NME11.77246184
25GRK51.74717711
26MKNK21.69889895
27CAMK2B1.67186565
28PINK11.64513635
29FER1.57904614
30DAPK21.53817242
31MAP2K41.53570000
32DAPK11.49139961
33KSR11.46225406
34CAMK2A1.39971566
35INSRR1.39435342
36MAP3K91.35036487
37MAP3K21.23392908
38KSR21.21865201
39EPHA21.17917335
40CDK51.15569508
41BCR1.15221755
42PRPF4B1.15069628
43PAK61.14168746
44BRSK21.13088496
45TSSK61.11173775
46PRKCG1.06861501
47EIF2AK31.04086740
48PHKG11.04008256
49PHKG21.04008256
50LATS21.02702131
51SIK21.01844458
52WEE10.98982216
53DDR20.98576727
54PRKCE0.98149416
55AKT30.98120297
56TNIK0.98033856
57FES0.96469489
58PAK30.95288667
59MST40.94836511
60MOS0.94672854
61MAP2K10.94349910
62STK390.93117436
63BRD40.92793480
64ROCK20.92481443
65ADRBK20.91324177
66CAMK2D0.90079537
67MARK10.88669596
68NTRK20.88213560
69STK380.87339408
70SIK30.86363333
71TGFBR10.85726558
72PRKCI0.83007617
73OXSR10.81763425
74NEK10.79541936
75TNK20.76661224
76MAPK130.74419536
77SGK10.73940258
78TYRO30.72565569
79PTK20.72020647
80MKNK10.71892054
81CSNK1G10.70079580
82DMPK0.69558933
83CDK180.67982273
84SRPK10.67845938
85ARAF0.66826729
86CDK140.66648929
87MET0.65420561
88CAMKK10.64825205
89FGFR10.63624407
90CDK150.63211434
91FRK0.62650269
92MST1R0.62493688
93CAMK2G0.61829534
94PDGFRA0.60940480
95CDK190.59420395
96MUSK0.58288083
97RAF10.58196095
98MAP3K130.56848042
99DYRK1A0.56760138
100CDK11A0.55989785
101CSNK1G20.55024706
102IRAK20.54787516
103NLK0.54544409
104IRAK10.53336211
105ROCK10.52435689
106SGK2230.48825418
107SGK4940.48825418
108RET0.48736682
109OBSCN0.48475449
110PRKD30.48255846
111ADRBK10.47931745
112ERBB30.47462161
113LATS10.47164790
114BRSK10.47082820
115SGK20.46460443
116CAMK10.45042633
117PLK40.44751317
118TRPM70.44500626
119LIMK10.43894854
120CAMK1G0.43581179
121ZAK0.42511156
122PRKCQ0.42261681
123CAMKK20.41998806
124FYN0.41677456
125GRK70.41632863
126STK38L0.41509339
127MAPK100.41276249
128FGFR20.39184750
129BMX0.38854164
130PDGFRB0.38500742
131FLT30.38499888
132WNK40.38309367
133NUAK10.38063080
134CSNK1G30.37892731
135TESK10.37705156
136EIF2AK10.37537582
137MAP3K70.37059616
138NEK60.36056781
139GRK60.35955143
140PRKG10.35863935
141PDK20.35040385
142PRKACA0.34626678
143MYLK0.34453269
144SRC0.34083445
145PLK30.33463530
146PLK10.32126196
147PRKCA0.31955294
148CSNK1A10.31944198
149MAPKAPK50.31727322
150ERBB40.31239564
151VRK10.29721363
152PRKACB0.29010858
153SGK30.27850129
154PKN20.25426850
155EIF2AK20.25194934
156CSNK1D0.22517075
157CSNK1E0.19517071
158CSNK1A1L0.19256229

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94289020
2Protein export_Homo sapiens_hsa030603.52327191
3Long-term potentiation_Homo sapiens_hsa047202.84262890
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61408636
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.48794641
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45055330
7Glutamatergic synapse_Homo sapiens_hsa047242.43015516
8Circadian entrainment_Homo sapiens_hsa047132.42354554
9Amphetamine addiction_Homo sapiens_hsa050312.38377878
10Salivary secretion_Homo sapiens_hsa049702.27565400
11Propanoate metabolism_Homo sapiens_hsa006402.21201331
12Morphine addiction_Homo sapiens_hsa050322.16970641
13Olfactory transduction_Homo sapiens_hsa047402.14406114
14Synaptic vesicle cycle_Homo sapiens_hsa047212.11827917
15Proteasome_Homo sapiens_hsa030502.11804967
16Fatty acid elongation_Homo sapiens_hsa000622.10367861
17Taste transduction_Homo sapiens_hsa047422.10083413
18GABAergic synapse_Homo sapiens_hsa047272.07062401
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02184735
20Dopaminergic synapse_Homo sapiens_hsa047281.99454032
21Renin secretion_Homo sapiens_hsa049241.97648665
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91676673
23Butanoate metabolism_Homo sapiens_hsa006501.85931144
24Oxidative phosphorylation_Homo sapiens_hsa001901.83971100
25Long-term depression_Homo sapiens_hsa047301.82918863
26Serotonergic synapse_Homo sapiens_hsa047261.77772009
27Collecting duct acid secretion_Homo sapiens_hsa049661.75707939
28* Axon guidance_Homo sapiens_hsa043601.74697159
29Sulfur metabolism_Homo sapiens_hsa009201.73804488
30Gastric acid secretion_Homo sapiens_hsa049711.72656371
31Calcium signaling pathway_Homo sapiens_hsa040201.71435947
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69435315
33Oxytocin signaling pathway_Homo sapiens_hsa049211.67533268
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66452013
35Selenocompound metabolism_Homo sapiens_hsa004501.55825739
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52886871
37Cholinergic synapse_Homo sapiens_hsa047251.51506772
38Pyruvate metabolism_Homo sapiens_hsa006201.51170500
39Peroxisome_Homo sapiens_hsa041461.48247049
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47723979
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44345430
42Fatty acid metabolism_Homo sapiens_hsa012121.41934383
43Basal transcription factors_Homo sapiens_hsa030221.41581413
44GnRH signaling pathway_Homo sapiens_hsa049121.40784087
45Nitrogen metabolism_Homo sapiens_hsa009101.40470866
46Insulin secretion_Homo sapiens_hsa049111.38774031
47Parkinsons disease_Homo sapiens_hsa050121.38284900
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37995144
49Circadian rhythm_Homo sapiens_hsa047101.37436339
50Gap junction_Homo sapiens_hsa045401.35065129
51Tryptophan metabolism_Homo sapiens_hsa003801.30871394
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29308958
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28651095
54Melanogenesis_Homo sapiens_hsa049161.27095618
55cAMP signaling pathway_Homo sapiens_hsa040241.24692828
56Vibrio cholerae infection_Homo sapiens_hsa051101.24427357
57Steroid biosynthesis_Homo sapiens_hsa001001.23224363
58Phototransduction_Homo sapiens_hsa047441.22160296
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21958888
60beta-Alanine metabolism_Homo sapiens_hsa004101.21031985
61Glioma_Homo sapiens_hsa052141.17316264
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16471987
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.15365438
64Sphingolipid metabolism_Homo sapiens_hsa006001.14411168
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14247551
66Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12478374
67Cocaine addiction_Homo sapiens_hsa050301.12447900
68Folate biosynthesis_Homo sapiens_hsa007901.11773378
69Non-homologous end-joining_Homo sapiens_hsa034501.10289112
70cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08970680
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07176926
72Vascular smooth muscle contraction_Homo sapiens_hsa042701.06330592
73Dilated cardiomyopathy_Homo sapiens_hsa054141.05790543
74Fanconi anemia pathway_Homo sapiens_hsa034601.05627688
75Estrogen signaling pathway_Homo sapiens_hsa049151.05252257
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05217476
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99972126
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.99767756
79Homologous recombination_Homo sapiens_hsa034400.98260487
80Fatty acid degradation_Homo sapiens_hsa000710.97862902
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96218135
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96121016
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94849285
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94128728
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94065499
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93143351
87Rap1 signaling pathway_Homo sapiens_hsa040150.92987720
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92847242
89Glutathione metabolism_Homo sapiens_hsa004800.92594836
90ECM-receptor interaction_Homo sapiens_hsa045120.92142240
91ErbB signaling pathway_Homo sapiens_hsa040120.91934785
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90541995
93Ether lipid metabolism_Homo sapiens_hsa005650.89122853
94RNA degradation_Homo sapiens_hsa030180.87582053
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87501163
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84323522
97VEGF signaling pathway_Homo sapiens_hsa043700.83681677
98Ras signaling pathway_Homo sapiens_hsa040140.83596582
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81877384
100Arginine and proline metabolism_Homo sapiens_hsa003300.81806692
101Thyroid hormone synthesis_Homo sapiens_hsa049180.81399923
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80085168
103Basal cell carcinoma_Homo sapiens_hsa052170.79527583
104Wnt signaling pathway_Homo sapiens_hsa043100.78268040
105Pancreatic secretion_Homo sapiens_hsa049720.76257929
106Huntingtons disease_Homo sapiens_hsa050160.76118061
107Choline metabolism in cancer_Homo sapiens_hsa052310.75931365
108Regulation of autophagy_Homo sapiens_hsa041400.75844753
109Focal adhesion_Homo sapiens_hsa045100.75516276
110Tight junction_Homo sapiens_hsa045300.74686392
111Oocyte meiosis_Homo sapiens_hsa041140.73355910
112Chemical carcinogenesis_Homo sapiens_hsa052040.72140583
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71203096
114MAPK signaling pathway_Homo sapiens_hsa040100.71170887
115Rheumatoid arthritis_Homo sapiens_hsa053230.70547200
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70116996
117Adherens junction_Homo sapiens_hsa045200.69834416
118Cardiac muscle contraction_Homo sapiens_hsa042600.69790296
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.68730607
120African trypanosomiasis_Homo sapiens_hsa051430.68684945
121Alzheimers disease_Homo sapiens_hsa050100.68121586
122Retinol metabolism_Homo sapiens_hsa008300.67935608
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66241624
124ABC transporters_Homo sapiens_hsa020100.66106394
125Metabolic pathways_Homo sapiens_hsa011000.65133312
126Hippo signaling pathway_Homo sapiens_hsa043900.64473267
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63794630
128Vitamin digestion and absorption_Homo sapiens_hsa049770.63488636
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.62838581
130Mineral absorption_Homo sapiens_hsa049780.60338844
131Dorso-ventral axis formation_Homo sapiens_hsa043200.59806234
132Linoleic acid metabolism_Homo sapiens_hsa005910.59804333
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58398822
134Proteoglycans in cancer_Homo sapiens_hsa052050.56861939
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56447458
136Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56388698
137Amoebiasis_Homo sapiens_hsa051460.55879372
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53640751
139Melanoma_Homo sapiens_hsa052180.53007379
140RNA polymerase_Homo sapiens_hsa030200.52797579
141Glucagon signaling pathway_Homo sapiens_hsa049220.51656273
142Salmonella infection_Homo sapiens_hsa051320.50889950
143Phagosome_Homo sapiens_hsa041450.50330456
144Hedgehog signaling pathway_Homo sapiens_hsa043400.50308584
145Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48919476
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48566507
147Fat digestion and absorption_Homo sapiens_hsa049750.48493350
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48259803
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.47860682
150Mismatch repair_Homo sapiens_hsa034300.47070302
151Inositol phosphate metabolism_Homo sapiens_hsa005620.46531981
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46285813
153TGF-beta signaling pathway_Homo sapiens_hsa043500.46222598
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45820989
155Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45760144
156Purine metabolism_Homo sapiens_hsa002300.44787162
157Type II diabetes mellitus_Homo sapiens_hsa049300.44246702
158Renal cell carcinoma_Homo sapiens_hsa052110.44219910
159Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44195312
160Type I diabetes mellitus_Homo sapiens_hsa049400.43592047
161Platelet activation_Homo sapiens_hsa046110.39685094
162Shigellosis_Homo sapiens_hsa051310.38243488
163Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37464720
164Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36705704
165Endocytosis_Homo sapiens_hsa041440.36228263
166Bladder cancer_Homo sapiens_hsa052190.35846203

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