SEMA3F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.87408985
2regulation of water loss via skin (GO:0033561)4.83180782
3establishment of skin barrier (GO:0061436)4.59451254
4desmosome organization (GO:0002934)4.41597043
5keratinocyte proliferation (GO:0043616)3.95690539
6lymphangiogenesis (GO:0001946)3.87231450
7vascular endothelial growth factor signaling pathway (GO:0038084)3.86079334
8negative regulation of keratinocyte proliferation (GO:0010839)3.84987788
9bundle of His cell to Purkinje myocyte communication (GO:0086069)3.82024321
10surfactant homeostasis (GO:0043129)3.73209088
11* semaphorin-plexin signaling pathway (GO:0071526)3.71358732
12lymph vessel development (GO:0001945)3.68902579
13planar cell polarity pathway involved in neural tube closure (GO:0090179)3.64568217
14cell-substrate adherens junction assembly (GO:0007045)3.63635568
15focal adhesion assembly (GO:0048041)3.63635568
16hippo signaling (GO:0035329)3.62723337
17polarized epithelial cell differentiation (GO:0030859)3.52126627
18chondrocyte proliferation (GO:0035988)3.51801031
19cell-substrate junction assembly (GO:0007044)3.50511421
20COPI coating of Golgi vesicle (GO:0048205)3.48351101
21Golgi transport vesicle coating (GO:0048200)3.48351101
22epithelial cell-cell adhesion (GO:0090136)3.48187768
23mesodermal cell differentiation (GO:0048333)3.46446073
24protein heterotrimerization (GO:0070208)3.45407812
25multicellular organismal water homeostasis (GO:0050891)3.45338927
26endothelial cell chemotaxis (GO:0035767)3.44975639
27cell migration involved in sprouting angiogenesis (GO:0002042)3.44776684
28regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.43657150
29renal filtration (GO:0097205)3.42013905
30establishment of tissue polarity (GO:0007164)3.41216936
31establishment of planar polarity (GO:0001736)3.41216936
32blood vessel maturation (GO:0001955)3.40025927
33regulation of hair follicle development (GO:0051797)3.36090524
34cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.33824383
35mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.33141665
36gap junction assembly (GO:0016264)3.31976573
37wound healing, spreading of epidermal cells (GO:0035313)3.27765212
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.24490870
39cell adhesion mediated by integrin (GO:0033627)3.23894483
40Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.21689742
41renal system development (GO:0072001)3.19378404
42protein retention in ER lumen (GO:0006621)3.18641182
43basement membrane organization (GO:0071711)3.17644395
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.17622712
45positive regulation of epidermis development (GO:0045684)3.17052682
46protein localization to endosome (GO:0036010)3.16703969
47outer ear morphogenesis (GO:0042473)3.15908447
48retina vasculature morphogenesis in camera-type eye (GO:0061299)3.14178123
49positive regulation of epidermal cell differentiation (GO:0045606)3.13121125
50epithelial cell differentiation involved in prostate gland development (GO:0060742)3.12060143
51plasma membrane repair (GO:0001778)3.08795391
52* neuron projection extension involved in neuron projection guidance (GO:1902284)3.08756602
53* axon extension involved in axon guidance (GO:0048846)3.08756602
54endodermal cell differentiation (GO:0035987)3.08244487
55branching involved in mammary gland duct morphogenesis (GO:0060444)3.04765083
56ear development (GO:0043583)3.03787169
57embryonic foregut morphogenesis (GO:0048617)3.03710518
58endothelial cell morphogenesis (GO:0001886)3.03557117
59positive regulation of blood vessel endothelial cell migration (GO:0043536)3.03541160
60collagen fibril organization (GO:0030199)3.03391855
61regulation of establishment of planar polarity (GO:0090175)3.03373743
62positive regulation of keratinocyte differentiation (GO:0045618)3.03354277
63regulation of endothelial cell differentiation (GO:0045601)3.02970441
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.02578054
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.00063680
66endothelium development (GO:0003158)2.98234070
67chemical homeostasis within a tissue (GO:0048875)2.97712721
68cell junction assembly (GO:0034329)2.97339620
69negative regulation of cell fate specification (GO:0009996)2.97093640
70branching involved in salivary gland morphogenesis (GO:0060445)2.95718394
71metanephric mesenchyme development (GO:0072075)2.95603514
72atrioventricular valve morphogenesis (GO:0003181)2.95377601
73skin morphogenesis (GO:0043589)2.95124090
74glomerular basement membrane development (GO:0032836)2.94439485
75blood vessel endothelial cell migration (GO:0043534)2.94415192
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92895190
77establishment of apical/basal cell polarity (GO:0035089)2.90800331
78lung vasculature development (GO:0060426)2.90235491
79regulation of hippo signaling (GO:0035330)2.90187920
80epidermis development (GO:0008544)2.89370409
81morphogenesis of an endothelium (GO:0003159)2.89264387
82endothelial tube morphogenesis (GO:0061154)2.89264387
83negative regulation of catenin import into nucleus (GO:0035414)2.88869582
84positive regulation of hair cycle (GO:0042635)2.87445536
85positive regulation of hair follicle development (GO:0051798)2.87445536
86coronary vasculature morphogenesis (GO:0060977)2.85958762
87insulin-like growth factor receptor signaling pathway (GO:0048009)2.84977066
88cell proliferation involved in metanephros development (GO:0072203)2.84014852
89paraxial mesoderm development (GO:0048339)2.83509017
90activation of Rac GTPase activity (GO:0032863)2.83408731
91negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.82470115
92negative regulation of fatty acid transport (GO:2000192)2.80959057
93regulation of transforming growth factor beta2 production (GO:0032909)2.80378182
94cell junction organization (GO:0034330)2.80311856
95regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.78023428
96bone trabecula formation (GO:0060346)2.76983212
97mesenchyme morphogenesis (GO:0072132)2.76913529
98regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.76816506
99lung lobe morphogenesis (GO:0060463)2.76255848
100kidney mesenchyme development (GO:0072074)2.76066385
101collecting duct development (GO:0072044)2.75958046
102apoptotic process involved in morphogenesis (GO:0060561)2.72000383
103negative regulation of cartilage development (GO:0061037)2.71593601
104endocardial cushion development (GO:0003197)2.71036948
105cell migration involved in heart development (GO:0060973)2.70101836
106negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.69552325
107endocardial cushion morphogenesis (GO:0003203)2.68965057
108respiratory tube development (GO:0030323)2.68811472
109regulation of cardioblast differentiation (GO:0051890)2.67942993
110glomerular filtration (GO:0003094)2.67448973
111collagen metabolic process (GO:0032963)2.66650969
112water homeostasis (GO:0030104)2.66538833
113positive regulation of endothelial cell differentiation (GO:0045603)2.66526817
114establishment of monopolar cell polarity (GO:0061162)2.66376494
115establishment or maintenance of monopolar cell polarity (GO:0061339)2.66376494
116negative regulation of chondrocyte differentiation (GO:0032331)2.66058034
117artery development (GO:0060840)2.63906378
118extracellular matrix disassembly (GO:0022617)2.62397390
119multicellular organismal macromolecule metabolic process (GO:0044259)2.60914254
120lung-associated mesenchyme development (GO:0060484)2.60672482
121regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.59990965
122adherens junction assembly (GO:0034333)2.59967513
123keratinocyte differentiation (GO:0030216)2.59768718
124stress fiber assembly (GO:0043149)2.59209554
125regulation of heart morphogenesis (GO:2000826)2.58743365
126regulation of endothelial cell chemotaxis (GO:2001026)2.58724523
127camera-type eye morphogenesis (GO:0048593)2.58332663
128ectoderm development (GO:0007398)2.57922942
129regulation of keratinocyte proliferation (GO:0010837)2.57109521
130sequestering of extracellular ligand from receptor (GO:0035581)2.56587802
131G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.56394061
132positive regulation of mesenchymal cell proliferation (GO:0002053)2.55216353
133negative regulation of cell size (GO:0045792)2.54461917
134retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54447783
135collagen catabolic process (GO:0030574)2.54423223
136keratinization (GO:0031424)2.54400790
137vasculogenesis (GO:0001570)2.54284629
138wound healing, spreading of cells (GO:0044319)2.53575391
139aorta morphogenesis (GO:0035909)2.52799285
140pattern specification involved in kidney development (GO:0061004)2.52661657
141intermediate filament organization (GO:0045109)2.52028802
142* regulation of axon extension involved in axon guidance (GO:0048841)2.51759948
143non-canonical Wnt signaling pathway (GO:0035567)2.51550723
144adherens junction organization (GO:0034332)2.50385056
145positive regulation of cartilage development (GO:0061036)2.50035174
146regulation of glomerular filtration (GO:0003093)2.49863718
147midgut development (GO:0007494)2.49103051
148vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49008595
149convergent extension (GO:0060026)2.48831352
150L-serine transport (GO:0015825)2.45981328
151skin development (GO:0043588)2.41824373
152negative regulation of adherens junction organization (GO:1903392)2.41178742
153negative regulation of cell junction assembly (GO:1901889)2.41178742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.60225925
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.97115597
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.20513262
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.91199646
5CLOCK_20551151_ChIP-Seq_293T_Human2.61394001
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54859461
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.15273486
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.13783696
9* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12479610
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96582892
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96327239
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93288179
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93288179
14* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85177892
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.84564821
16HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80492440
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.80090714
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78879182
19EP300_21415370_ChIP-Seq_HL-1_Mouse1.76899180
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70827930
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70725011
22* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70075763
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69247968
24* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67895336
25* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65497001
26SOX9_24532713_ChIP-Seq_HFSC_Mouse1.64920317
27TP53_20018659_ChIP-ChIP_R1E_Mouse1.64900477
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.63447768
29* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63242319
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62645160
31KDM2B_26808549_Chip-Seq_K562_Human1.60680953
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59610213
33* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58626358
34ZNF263_19887448_ChIP-Seq_K562_Human1.57279042
35* ELK3_25401928_ChIP-Seq_HUVEC_Human1.54963240
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.54169074
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54003940
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52179348
39CJUN_26792858_Chip-Seq_BT549_Human1.51754980
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50162793
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49553106
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48751987
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46669650
44RACK7_27058665_Chip-Seq_MCF-7_Human1.46262553
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.44235193
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.43376279
47ISL1_27105846_Chip-Seq_CPCs_Mouse1.42902111
48* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41892366
49SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40054746
50SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40054746
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36924755
52CTCF_27219007_Chip-Seq_Bcells_Human1.35953644
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35665925
54* EZH2_27294783_Chip-Seq_ESCs_Mouse1.35117363
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34794113
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34621328
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34568697
58* AHR_22903824_ChIP-Seq_MCF-7_Human1.34417174
59TP53_22127205_ChIP-Seq_IMR90_Human1.33706611
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33163672
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31552817
62* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31482147
63* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30537653
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.29210311
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29081911
66* TP63_22573176_ChIP-Seq_HFKS_Human1.28177199
67LXR_22292898_ChIP-Seq_THP-1_Human1.26936263
68* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26712504
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.26378309
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25954462
71CREB1_26743006_Chip-Seq_LNCaP_Human1.25655111
72* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24561322
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24398689
74* RUNX1_27514584_Chip-Seq_MCF-7_Human1.24039306
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23335179
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.22588880
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.22588880
78TCF7_22412390_ChIP-Seq_EML_Mouse1.21903479
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21331054
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20545386
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20182077
82* SMC4_20622854_ChIP-Seq_HELA_Human1.20158631
83* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19955873
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19828200
85* RING1B_27294783_Chip-Seq_NPCs_Mouse1.19688631
86* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17949286
87* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17421803
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.17291609
89CDX2_20551321_ChIP-Seq_CACO-2_Human1.17183848
90TET1_21490601_ChIP-Seq_MESCs_Mouse1.15493876
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15455273
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.14805757
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14691082
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.14218658
95KLF5_25053715_ChIP-Seq_YYC3_Human1.14203598
96* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14099413
97* P68_20966046_ChIP-Seq_HELA_Human1.14063676
98* ARNT_22903824_ChIP-Seq_MCF-7_Human1.12550083
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11117651
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10446960
101* SOX2_20726797_ChIP-Seq_SW620_Human1.09910174
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09780206
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09681650
104ATF3_27146783_Chip-Seq_COLON_Human1.08497193
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08493091
106TET1_21451524_ChIP-Seq_MESCs_Mouse1.08068971
107BRD4_25478319_ChIP-Seq_HGPS_Human1.07132284
108* TCF4_18268006_ChIP-ChIP_LS174T_Human1.06450361
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06384766
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05411166
111SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05251631
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04560504
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02223516
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01541760
115* KDM2B_26808549_Chip-Seq_DND41_Human1.01478808
116NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00131711
117* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99884686
118DROSHA_22980978_ChIP-Seq_HELA_Human0.99214106
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98245270
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97927890
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97411574
122TP53_18474530_ChIP-ChIP_U2OS_Human0.97344645
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97125081
124TP53_23651856_ChIP-Seq_MEFs_Mouse0.96753764
125VDR_21846776_ChIP-Seq_THP-1_Human0.96014429
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.95573605
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95116041
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95093793
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94652355
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94353116
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92737869
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91498144
133SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88799321
134NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86337245
135STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.85499725
136SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83459823
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82425595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.98299883
2MP0005275_abnormal_skin_tensile3.97922467
3MP0004272_abnormal_basement_membrane3.69262487
4MP0008438_abnormal_cutaneous_collagen3.54781364
5MP0010368_abnormal_lymphatic_system3.09323175
6MP0005409_darkened_coat_color2.86043370
7MP0010030_abnormal_orbit_morphology2.71295314
8MP0000537_abnormal_urethra_morphology2.59431832
9MP0001958_emphysema2.57774009
10MP0010234_abnormal_vibrissa_follicle2.56141929
11MP0005623_abnormal_meninges_morphology2.44762036
12MP0003566_abnormal_cell_adhesion2.35345895
13MP0006054_spinal_hemorrhage2.32597678
14MP0001879_abnormal_lymphatic_vessel2.31837775
15MP0009053_abnormal_anal_canal2.29582562
16MP0002796_impaired_skin_barrier2.18520212
17MP0000534_abnormal_ureter_morphology2.10463949
18MP0005503_abnormal_tendon_morphology1.99912408
19MP0002234_abnormal_pharynx_morphology1.92231281
20MP0003941_abnormal_skin_development1.91639389
21MP0002060_abnormal_skin_morphology1.91469460
22MP0003385_abnormal_body_wall1.88056188
23MP0000566_synostosis1.83344091
24MP0000579_abnormal_nail_morphology1.82634722
25MP0003279_aneurysm1.80040570
26MP0003942_abnormal_urinary_system1.78769954
27MP0000678_abnormal_parathyroid_gland1.76830878
28MP0001849_ear_inflammation1.65392232
29MP0004381_abnormal_hair_follicle1.63859453
30MP0000762_abnormal_tongue_morphology1.53695632
31MP0000467_abnormal_esophagus_morphology1.47487935
32MP0002254_reproductive_system_inflammat1.45825882
33MP0003115_abnormal_respiratory_system1.44457204
34MP0010678_abnormal_skin_adnexa1.43471358
35MP0005501_abnormal_skin_physiology1.42515673
36MP0005367_renal/urinary_system_phenotyp1.41677203
37MP0000516_abnormal_urinary_system1.41677203
38MP0005508_abnormal_skeleton_morphology1.41669026
39MP0003283_abnormal_digestive_organ1.39908606
40MP0000767_abnormal_smooth_muscle1.39508596
41MP0000383_abnormal_hair_follicle1.38885060
42MP0002877_abnormal_melanocyte_morpholog1.36389212
43MP0010352_gastrointestinal_tract_polyps1.36057020
44MP0000733_abnormal_muscle_development1.35537788
45MP0009250_abnormal_appendicular_skeleto1.33611166
46MP0003453_abnormal_keratinocyte_physiol1.32298937
47MP0004084_abnormal_cardiac_muscle1.31971417
48MP0005248_abnormal_Harderian_gland1.27041823
49MP0005023_abnormal_wound_healing1.26833884
50MP0002098_abnormal_vibrissa_morphology1.26787001
51MP0003091_abnormal_cell_migration1.20104141
52MP0002282_abnormal_trachea_morphology1.18850042
53MP0000013_abnormal_adipose_tissue1.18415685
54MP0000049_abnormal_middle_ear1.18406037
55MP0000428_abnormal_craniofacial_morphol1.17095190
56MP0003755_abnormal_palate_morphology1.16362910
57MP0003122_maternal_imprinting1.15099659
58MP0009384_cardiac_valve_regurgitation1.14398508
59MP0003935_abnormal_craniofacial_develop1.13052004
60MP0001346_abnormal_lacrimal_gland1.12593546
61MP0002089_abnormal_postnatal_growth/wei1.11178557
62MP0009931_abnormal_skin_appearance1.09532486
63MP0002249_abnormal_larynx_morphology1.09265022
64MP0010771_integument_phenotype1.09159301
65MP0000627_abnormal_mammary_gland1.08724218
66MP0002295_abnormal_pulmonary_circulatio1.08123812
67MP0005187_abnormal_penis_morphology1.06907518
68MP0001216_abnormal_epidermal_layer1.06286298
69MP0002932_abnormal_joint_morphology1.06156746
70MP0002925_abnormal_cardiovascular_devel1.05651347
71MP0008260_abnormal_autophagy1.05541486
72MP0002233_abnormal_nose_morphology1.04186978
73MP0006138_congestive_heart_failure1.02840503
74MP0005167_abnormal_blood-brain_barrier1.02570986
75MP0002896_abnormal_bone_mineralization1.02534765
76MP0005076_abnormal_cell_differentiation1.02112487
77MP0003937_abnormal_limbs/digits/tail_de1.02016257
78MP0003119_abnormal_digestive_system1.01460187
79MP0000751_myopathy0.99282356
80MP0009780_abnormal_chondrocyte_physiolo0.98821044
81MP0000462_abnormal_digestive_system0.98803681
82MP0000647_abnormal_sebaceous_gland0.98780976
83MP0002653_abnormal_ependyma_morphology0.95258653
84MP0003011_delayed_dark_adaptation0.95197352
85MP0003315_abnormal_perineum_morphology0.94947819
86MP0005257_abnormal_intraocular_pressure0.93126311
87MP0004185_abnormal_adipocyte_glucose0.92067150
88MP0000427_abnormal_hair_cycle0.92063642
89MP0004233_abnormal_muscle_weight0.90735852
90MP0000377_abnormal_hair_follicle0.89490536
91MP0005394_taste/olfaction_phenotype0.89067101
92MP0005499_abnormal_olfactory_system0.89067101
93MP0001614_abnormal_blood_vessel0.88665023
94MP0001243_abnormal_dermal_layer0.88184951
95MP0002138_abnormal_hepatobiliary_system0.87216840
96MP0001348_abnormal_lacrimal_gland0.86207081
97MP0002128_abnormal_blood_circulation0.83861264
98MP0004858_abnormal_nervous_system0.83394698
99MP0005083_abnormal_biliary_tract0.83139596
100MP0009379_abnormal_foot_pigmentation0.82571610
101MP0000003_abnormal_adipose_tissue0.82426351
102MP0003123_paternal_imprinting0.81652497
103MP0000163_abnormal_cartilage_morphology0.80889786
104MP0002116_abnormal_craniofacial_bone0.80411076
105MP0005375_adipose_tissue_phenotype0.80224966
106MP0008789_abnormal_olfactory_epithelium0.79883127
107MP0002697_abnormal_eye_size0.78695700
108MP0004264_abnormal_extraembryonic_tissu0.78515606
109MP0001270_distended_abdomen0.76763283
110MP0004782_abnormal_surfactant_physiolog0.75130235
111MP0010630_abnormal_cardiac_muscle0.74260641
112MP0001299_abnormal_eye_distance/0.73274308
113MP0003191_abnormal_cellular_cholesterol0.72853115
114MP0002111_abnormal_tail_morphology0.72032099
115MP0002108_abnormal_muscle_morphology0.71686007
116MP0009278_abnormal_bone_marrow0.71663046
117MP0002115_abnormal_skeleton_extremities0.70391555
118MP0005197_abnormal_uvea_morphology0.69858928
119MP0001340_abnormal_eyelid_morphology0.69703130
120MP0000538_abnormal_urinary_bladder0.68288437
121MP0000367_abnormal_coat/_hair0.66070630
122MP0002092_abnormal_eye_morphology0.65770718
123MP0005360_urolithiasis0.64764648
124MP0005058_abnormal_lysosome_morphology0.63065537
125MP0000432_abnormal_head_morphology0.62609527
126MP0005451_abnormal_body_composition0.60560562

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)5.33823485
2Atrophic scars (HP:0001075)4.93789314
3Premature rupture of membranes (HP:0001788)4.38256693
4Protrusio acetabuli (HP:0003179)4.38123533
5Thick nail (HP:0001805)4.19797135
6Milia (HP:0001056)4.18072471
7Right ventricular cardiomyopathy (HP:0011663)4.02454792
8Shallow orbits (HP:0000586)3.99429189
9Onycholysis (HP:0001806)3.43211810
10Cerebral aneurysm (HP:0004944)3.37943717
11Natal tooth (HP:0000695)3.33974559
12Palmoplantar hyperkeratosis (HP:0000972)3.32129357
13Broad metatarsal (HP:0001783)3.29644691
14Fragile nails (HP:0001808)3.27660016
15Bladder diverticulum (HP:0000015)3.27545448
16Fragile skin (HP:0001030)3.26472582
17Ankle contracture (HP:0006466)3.23912590
18Ridged nail (HP:0001807)3.16948411
19Selective tooth agenesis (HP:0001592)3.13271053
20Pterygium (HP:0001059)3.12425901
21Palmar hyperkeratosis (HP:0010765)3.07839283
22Aortic dissection (HP:0002647)3.01618411
23Increased connective tissue (HP:0009025)2.97006226
24Abnormal hair laboratory examination (HP:0003328)2.87924088
25Aortic aneurysm (HP:0004942)2.85945918
26Flat acetabular roof (HP:0003180)2.76279370
27Broad face (HP:0000283)2.67020523
28Renal duplication (HP:0000075)2.65580803
29Mitral valve prolapse (HP:0001634)2.62756750
30Hypoplasia of dental enamel (HP:0006297)2.62267966
31Short 4th metacarpal (HP:0010044)2.61563026
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.61563026
33Abnormal blistering of the skin (HP:0008066)2.57772490
34Type 1 muscle fiber predominance (HP:0003803)2.55068169
35Short nail (HP:0001799)2.53524552
36Plantar hyperkeratosis (HP:0007556)2.50739910
37Pili torti (HP:0003777)2.50378326
38Lip pit (HP:0100267)2.50352311
39Spinal rigidity (HP:0003306)2.45130638
40Distal lower limb muscle weakness (HP:0009053)2.42013534
41Ankyloglossia (HP:0010296)2.42002535
42Vascular tortuosity (HP:0004948)2.41410820
43Dilatation of the ascending aorta (HP:0005111)2.39651571
44Follicular hyperkeratosis (HP:0007502)2.37032210
45Woolly hair (HP:0002224)2.36087849
46Bowel diverticulosis (HP:0005222)2.35323918
47Thin bony cortex (HP:0002753)2.35086194
48Deviation of the hallux (HP:0010051)2.33237601
49Neonatal short-limb short stature (HP:0008921)2.31639301
50Bronchomalacia (HP:0002780)2.31187467
51Wrist flexion contracture (HP:0001239)2.30227884
52Hyperacusis (HP:0010780)2.28752963
53Hypotrichosis (HP:0001006)2.28533766
54Lymphangioma (HP:0100764)2.28459521
55Abnormality of the 4th metacarpal (HP:0010012)2.25767864
56Hallux valgus (HP:0001822)2.25550788
57Buphthalmos (HP:0000557)2.23693387
58Hematochezia (HP:0002573)2.21628576
59Chorioretinal atrophy (HP:0000533)2.21476803
60Aneurysm (HP:0002617)2.20783925
61Increased variability in muscle fiber diameter (HP:0003557)2.19492096
62Alopecia of scalp (HP:0002293)2.19489549
63Aplasia cutis congenita (HP:0001057)2.19093376
64Abnormality of dentin (HP:0010299)2.17372998
65Soft skin (HP:0000977)2.15064965
66Asymmetry of the thorax (HP:0001555)2.14864293
67Neonatal death (HP:0003811)2.14363296
68Abnormality of the distal phalanges of the toes (HP:0010182)2.11759553
69Mildly elevated creatine phosphokinase (HP:0008180)2.10478528
70Peritonitis (HP:0002586)2.10115232
71Abnormality of oral frenula (HP:0000190)2.07464697
72Camptodactyly of toe (HP:0001836)2.07312856
73Anonychia (HP:0001798)2.06041033
74Sparse scalp hair (HP:0002209)2.04625590
75Obstructive sleep apnea (HP:0002870)2.03739731
76Long toe (HP:0010511)2.00661908
77Renovascular hypertension (HP:0100817)2.00462645
78Coronal craniosynostosis (HP:0004440)1.99884575
79Nail dystrophy (HP:0008404)1.99199078
80Abnormality of the salivary glands (HP:0010286)1.98235179
81Muscle fiber splitting (HP:0003555)1.97460524
82Abnormality of the distal phalanx of the thumb (HP:0009617)1.97292787
83Arterial tortuosity (HP:0005116)1.97086515
84Trismus (HP:0000211)1.96744211
85Flat cornea (HP:0007720)1.94350794
86Elfin facies (HP:0004428)1.92859580
87Polycythemia (HP:0001901)1.91796646
88Ulnar bowing (HP:0003031)1.89115093
89Aplasia involving bones of the extremities (HP:0009825)1.88390337
90Aplasia involving bones of the upper limbs (HP:0009823)1.88390337
91Aplasia of the phalanges of the hand (HP:0009802)1.88390337
92Abnormality of skeletal muscle fiber size (HP:0012084)1.87888366
93Blue sclerae (HP:0000592)1.87643687
94Difficulty climbing stairs (HP:0003551)1.86770078
95Germ cell neoplasia (HP:0100728)1.86010919
96Cervical subluxation (HP:0003308)1.85900243
97Scapular winging (HP:0003691)1.83988527
98Distal upper limb amyotrophy (HP:0007149)1.83897823
99Upper limb amyotrophy (HP:0009129)1.83897823
100Ventricular tachycardia (HP:0004756)1.83756063
101Oligodontia (HP:0000677)1.83742136
102Hyporeflexia of lower limbs (HP:0002600)1.81199583
103Back pain (HP:0003418)1.81161645
104Interstitial pulmonary disease (HP:0006530)1.81002054
105Genu recurvatum (HP:0002816)1.80432883
106Overriding aorta (HP:0002623)1.79951466
107Advanced eruption of teeth (HP:0006288)1.79913893
108Rectal prolapse (HP:0002035)1.79890595
109Laryngomalacia (HP:0001601)1.79658421
110Abnormality of the fetal cardiovascular system (HP:0010948)1.78139131
111Abnormal umbilical cord blood vessels (HP:0011403)1.78139131
112Single umbilical artery (HP:0001195)1.78139131
113Visceral angiomatosis (HP:0100761)1.77838044
114Acanthosis nigricans (HP:0000956)1.76847441
115Wormian bones (HP:0002645)1.76688290
116Sparse eyelashes (HP:0000653)1.76373160
117Arnold-Chiari malformation (HP:0002308)1.75420751
118Hydroureter (HP:0000072)1.74163438
119Down-sloping shoulders (HP:0200021)1.73995811
120Corneal erosion (HP:0200020)1.73754150
121Abnormality of permanent molar morphology (HP:0011071)1.73716387
122Abnormality of the dental root (HP:0006486)1.73716387
123Taurodontia (HP:0000679)1.73716387
124Overgrowth (HP:0001548)1.73504038
125Popliteal pterygium (HP:0009756)1.73233568
126Septate vagina (HP:0001153)1.73203060
127Elbow flexion contracture (HP:0002987)1.72220325
128Curly hair (HP:0002212)1.71900342
129Venous abnormality (HP:0002624)1.71900152
130Morphological abnormality of the middle ear (HP:0008609)1.70056031
131Absent eyelashes (HP:0000561)1.70037962
132Hypoventilation (HP:0002791)1.69678404
133Congenital glaucoma (HP:0001087)1.69676337
134Abnormality of the gastric mucosa (HP:0004295)1.69486530
135Abnormality of molar morphology (HP:0011070)1.68861497
136Abnormality of molar (HP:0011077)1.68861497
137Hepatoblastoma (HP:0002884)1.68626160
138Tarsal synostosis (HP:0008368)1.68363124
139Pigmentary retinal degeneration (HP:0001146)1.68048114
140Esophageal varix (HP:0002040)1.67611220
141Joint laxity (HP:0001388)1.67530454
142Mitral regurgitation (HP:0001653)1.67432166
143Wide anterior fontanel (HP:0000260)1.67301961
144Hyperextensible skin (HP:0000974)1.67260942
145Subacute progressive viral hepatitis (HP:0006572)1.66410736
146Long palpebral fissure (HP:0000637)1.66104514
147Bowed forearm bones (HP:0003956)1.65993261
148Bowing of the arm (HP:0006488)1.65993261
149Knee flexion contracture (HP:0006380)1.64958410
150Distal lower limb amyotrophy (HP:0008944)1.64740124
151Spinal cord compression (HP:0002176)1.63770537
152Skull defect (HP:0001362)1.63076942
153Achilles tendon contracture (HP:0001771)1.62820031
154Disproportionate tall stature (HP:0001519)1.62513803
155Abnormal ossification of hand bones (HP:0005921)1.61790603
156Vertebral compression fractures (HP:0002953)1.61249374
157Abnormal vertebral ossification (HP:0100569)1.60815683
158Abnormality of the acetabulum (HP:0003170)1.58585773
159Congenital ichthyosiform erythroderma (HP:0007431)1.58450315
160Coxa vara (HP:0002812)1.58405261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.14100760
2TIE13.95060999
3EPHB23.90375495
4LATS13.19414984
5RIPK13.10303371
6TTN2.94832543
7DDR22.93390593
8PKN22.89235303
9EPHA22.88970121
10FER2.80467560
11PDGFRA2.70582609
12SMG12.37980756
13TGFBR22.28022663
14PTK62.27677847
15LATS22.24062389
16ERN11.97274868
17PAK41.91880974
18ARAF1.88287743
19PTK21.82982214
20KDR1.79533666
21TGFBR11.68035360
22FGFR21.61163529
23LRRK21.52549109
24MAP3K61.41730625
25MAP3K101.40933189
26SIK11.36797076
27CDK121.33647426
28PIM21.30919278
29FGFR11.29999346
30EPHA31.29438423
31DMPK1.27998289
32EPHB11.27736468
33ICK1.27084840
34FGFR41.20815076
35IRAK31.15310537
36MAP3K31.14140589
37MAP3K91.13319001
38PAK31.09361822
39STK38L1.08038082
40NME21.05168325
41PAK21.02617287
42ERBB31.02059009
43MYLK1.00997322
44EEF2K0.98477497
45BMX0.93548469
46ILK0.92831547
47FGFR30.91973257
48PDGFRB0.89419676
49ERBB20.88032268
50LMTK20.87342158
51MAP3K20.87023214
52WNK40.86656862
53ROCK10.86410731
54MTOR0.84462019
55RPS6KC10.83677535
56RPS6KL10.83677535
57PRKD10.82514649
58PTK2B0.81389383
59GRK10.80474766
60RET0.79726055
61PRKD30.78056024
62FLT30.76048977
63MET0.74305711
64MAP2K10.73541373
65TRPM70.70974737
66MST1R0.70012123
67TYRO30.69042435
68RPS6KB20.67493593
69BRAF0.66830261
70MAP3K70.65842016
71MAPKAPK30.65703018
72RPS6KA60.63129948
73STK30.62040732
74TAOK10.61108300
75ROCK20.59914594
76CDC42BPA0.59014934
77DYRK1B0.58549687
78RPS6KA40.56974628
79PRKCH0.55039542
80PHKG10.53116548
81PHKG20.53116548
82SCYL20.52796774
83FRK0.50803643
84SRC0.50665535
85RPS6KA20.49017486
86MAPK150.48561317
87MAP2K20.48334538
88STK380.48122480
89MAP2K30.47195382
90PRKCI0.46848204
91PRKD20.46022533
92KSR20.45996915
93MAP3K10.45754173
94PRKG20.45630958
95CDK70.45441389
96PDPK10.44338697
97PRPF4B0.43179264
98LIMK10.43000614
99CAMK1G0.40900101
100BCR0.38516413
101RPS6KA10.38499342
102AKT20.38244408
103CDK60.37461844
104ADRBK10.37386805
105GSK3A0.37152772
106NEK60.36601968
107NME10.34011275
108KSR10.33439887
109STK240.31860732
110NEK10.31763910
111STK100.31679133
112CSNK1A1L0.31427219
113MARK20.29730018
114MAP3K110.29497816
115ERBB40.28917097
116DAPK20.27514536
117TESK10.25511952
118MAP3K80.25081725
119MUSK0.24892428
120TESK20.24455569
121RPS6KB10.24216070
122PRKCE0.23659947
123MAPK90.22869131
124CHUK0.22357719
125CAMK2G0.21972840
126NTRK10.21600625
127PIK3CA0.20672458
128INSR0.20330224
129EGFR0.20237295
130MAPKAPK20.19835629

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.48178779
2Basal cell carcinoma_Homo sapiens_hsa052172.66447251
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.59898844
4Focal adhesion_Homo sapiens_hsa045102.56297174
5Hippo signaling pathway_Homo sapiens_hsa043902.40398954
6Adherens junction_Homo sapiens_hsa045202.36840784
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.15141653
8Proteoglycans in cancer_Homo sapiens_hsa052052.12072374
9Dilated cardiomyopathy_Homo sapiens_hsa054141.96172033
10Bladder cancer_Homo sapiens_hsa052191.92698019
11Phototransduction_Homo sapiens_hsa047441.90557108
12Hedgehog signaling pathway_Homo sapiens_hsa043401.89644537
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.89035147
14Protein digestion and absorption_Homo sapiens_hsa049741.86719045
15Small cell lung cancer_Homo sapiens_hsa052221.85610324
16Tight junction_Homo sapiens_hsa045301.84513749
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.81940186
18Amoebiasis_Homo sapiens_hsa051461.76525568
19* Axon guidance_Homo sapiens_hsa043601.71176744
20Notch signaling pathway_Homo sapiens_hsa043301.67429501
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.63508590
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.55945027
23TGF-beta signaling pathway_Homo sapiens_hsa043501.46645436
24Endometrial cancer_Homo sapiens_hsa052131.40424466
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.39447729
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37050472
27Rap1 signaling pathway_Homo sapiens_hsa040151.32934067
28MicroRNAs in cancer_Homo sapiens_hsa052061.31168753
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.30564898
30Melanogenesis_Homo sapiens_hsa049161.29723730
31Pathways in cancer_Homo sapiens_hsa052001.27002326
32Renal cell carcinoma_Homo sapiens_hsa052111.26086880
33Other glycan degradation_Homo sapiens_hsa005111.25542563
34Chronic myeloid leukemia_Homo sapiens_hsa052201.25193625
35Wnt signaling pathway_Homo sapiens_hsa043101.24847529
36PI3K-Akt signaling pathway_Homo sapiens_hsa041511.21821816
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19188948
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14733953
39Dorso-ventral axis formation_Homo sapiens_hsa043201.10994903
40Prion diseases_Homo sapiens_hsa050201.06798303
41Melanoma_Homo sapiens_hsa052181.06399543
42VEGF signaling pathway_Homo sapiens_hsa043701.06377902
43Phenylalanine metabolism_Homo sapiens_hsa003601.06005614
44Galactose metabolism_Homo sapiens_hsa000521.04651003
45Glioma_Homo sapiens_hsa052141.04622731
46Estrogen signaling pathway_Homo sapiens_hsa049151.02431033
47Gap junction_Homo sapiens_hsa045401.00425866
48Toxoplasmosis_Homo sapiens_hsa051450.94340280
49Colorectal cancer_Homo sapiens_hsa052100.93212936
50Pancreatic cancer_Homo sapiens_hsa052120.93008214
51Thyroid cancer_Homo sapiens_hsa052160.92201531
52GnRH signaling pathway_Homo sapiens_hsa049120.89155159
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.88358443
54Fructose and mannose metabolism_Homo sapiens_hsa000510.87844348
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87558687
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86990500
57Arginine biosynthesis_Homo sapiens_hsa002200.86768753
58Inositol phosphate metabolism_Homo sapiens_hsa005620.85276836
59Pentose phosphate pathway_Homo sapiens_hsa000300.84756273
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84502245
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83982176
62Sphingolipid metabolism_Homo sapiens_hsa006000.83195697
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82511005
64Ras signaling pathway_Homo sapiens_hsa040140.81535691
65Vibrio cholerae infection_Homo sapiens_hsa051100.81309279
66Viral myocarditis_Homo sapiens_hsa054160.79160794
67Prostate cancer_Homo sapiens_hsa052150.78941652
68Platelet activation_Homo sapiens_hsa046110.78657826
69Choline metabolism in cancer_Homo sapiens_hsa052310.78235956
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.75936186
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75444942
72Insulin resistance_Homo sapiens_hsa049310.74635783
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74457669
74N-Glycan biosynthesis_Homo sapiens_hsa005100.74026212
75Renin secretion_Homo sapiens_hsa049240.72201986
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71888275
77HTLV-I infection_Homo sapiens_hsa051660.70455050
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68953041
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68530525
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67447885
81Biosynthesis of amino acids_Homo sapiens_hsa012300.66309151
82mTOR signaling pathway_Homo sapiens_hsa041500.65847747
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.64990426
84HIF-1 signaling pathway_Homo sapiens_hsa040660.64868837
85Gastric acid secretion_Homo sapiens_hsa049710.64491460
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63874360
87Glucagon signaling pathway_Homo sapiens_hsa049220.61967404
88ErbB signaling pathway_Homo sapiens_hsa040120.61274594
89Non-small cell lung cancer_Homo sapiens_hsa052230.61263610
90Hepatitis C_Homo sapiens_hsa051600.60990715
91TNF signaling pathway_Homo sapiens_hsa046680.60178421
92Endocytosis_Homo sapiens_hsa041440.57605697
93p53 signaling pathway_Homo sapiens_hsa041150.57532130
94Thyroid hormone synthesis_Homo sapiens_hsa049180.57186415
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56486446
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56277330
97Insulin signaling pathway_Homo sapiens_hsa049100.56157627
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55155825
99MAPK signaling pathway_Homo sapiens_hsa040100.54520936
100Oxytocin signaling pathway_Homo sapiens_hsa049210.54000660
101Acute myeloid leukemia_Homo sapiens_hsa052210.52716118
102FoxO signaling pathway_Homo sapiens_hsa040680.52487994
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51610054
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.51544885
105Prolactin signaling pathway_Homo sapiens_hsa049170.51205912
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51101839
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51011985
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49971063
109Lysine degradation_Homo sapiens_hsa003100.49464167
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.49137343
111AMPK signaling pathway_Homo sapiens_hsa041520.48263042
112Ovarian steroidogenesis_Homo sapiens_hsa049130.47937401
113Bile secretion_Homo sapiens_hsa049760.47885937
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47755804
115Malaria_Homo sapiens_hsa051440.46617535
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.45711031
117Cocaine addiction_Homo sapiens_hsa050300.44808105
118Lysosome_Homo sapiens_hsa041420.44718125
119Pancreatic secretion_Homo sapiens_hsa049720.44102664
120Sulfur relay system_Homo sapiens_hsa041220.43307370
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41989417
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41891054
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41549969
124Salmonella infection_Homo sapiens_hsa051320.41239488
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.41018153
126Shigellosis_Homo sapiens_hsa051310.39838212
127Salivary secretion_Homo sapiens_hsa049700.39484058
128Cholinergic synapse_Homo sapiens_hsa047250.39358451
129cAMP signaling pathway_Homo sapiens_hsa040240.39352096

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