SEMA3G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)8.59141158
2epithelial cell differentiation involved in kidney development (GO:0035850)8.08566808
3triglyceride catabolic process (GO:0019433)7.76376272
4acylglycerol catabolic process (GO:0046464)7.10757315
5neutral lipid catabolic process (GO:0046461)7.10757315
6positive regulation of p38MAPK cascade (GO:1900745)6.58750090
7transcytosis (GO:0045056)6.32259666
8regulation of sequestering of triglyceride (GO:0010889)6.12369259
9regulation of axon guidance (GO:1902667)5.42587121
10endothelial cell chemotaxis (GO:0035767)5.39256694
11surfactant homeostasis (GO:0043129)5.31173159
12diacylglycerol metabolic process (GO:0046339)5.25371175
13NADH metabolic process (GO:0006734)5.19105932
14glycerolipid catabolic process (GO:0046503)5.18586405
15regulation of p38MAPK cascade (GO:1900744)5.02508482
16lymphangiogenesis (GO:0001946)4.91327165
17vascular endothelial growth factor signaling pathway (GO:0038084)4.86365036
18coronary vasculature morphogenesis (GO:0060977)4.75219804
19cell adhesion mediated by integrin (GO:0033627)4.65546329
20negative regulation of axon guidance (GO:1902668)4.65214386
21activation of Rac GTPase activity (GO:0032863)4.58244690
22regulation of endothelial cell chemotaxis (GO:2001026)4.57937766
23positive regulation of cell adhesion mediated by integrin (GO:0033630)4.55499198
24renal filtration (GO:0097205)4.53669234
25retina vasculature morphogenesis in camera-type eye (GO:0061299)4.51145481
26angiotensin maturation (GO:0002003)4.50460706
27venous blood vessel morphogenesis (GO:0048845)4.48760875
28fatty acid homeostasis (GO:0055089)4.47890741
29lung vasculature development (GO:0060426)4.45148183
30regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.44456812
31ovulation from ovarian follicle (GO:0001542)4.40454621
32response to dietary excess (GO:0002021)4.37713375
33regulation of cholesterol storage (GO:0010885)4.30918927
34polyol transport (GO:0015791)4.25111375
35chemical homeostasis within a tissue (GO:0048875)4.23458391
36lipid storage (GO:0019915)4.18168488
37plasma lipoprotein particle clearance (GO:0034381)4.15724404
38positive regulation of vascular permeability (GO:0043117)4.14914403
39regulation of glomerular filtration (GO:0003093)4.14069968
40wound healing, spreading of epidermal cells (GO:0035313)4.07880208
41regulation of axon extension involved in axon guidance (GO:0048841)4.07748721
42negative regulation of homotypic cell-cell adhesion (GO:0034111)4.05297123
43regulation of cell migration involved in sprouting angiogenesis (GO:0090049)4.01434237
44cell migration involved in sprouting angiogenesis (GO:0002042)4.00395885
45regulation of glycogen (starch) synthase activity (GO:2000465)3.95286870
46positive regulation of triglyceride lipase activity (GO:0061365)3.94711363
47positive regulation of lipoprotein lipase activity (GO:0051006)3.94711363
48positive regulation of glomerulus development (GO:0090193)3.88756903
49endothelium development (GO:0003158)3.84079240
50auditory receptor cell stereocilium organization (GO:0060088)3.73783901
51positive regulation of lipid storage (GO:0010884)3.70855726
52ethanol oxidation (GO:0006069)3.70652333
53vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.70608508
54kidney mesenchyme development (GO:0072074)3.70154172
55negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.69579575
56cell differentiation involved in kidney development (GO:0061005)3.66272650
57cellular response to epinephrine stimulus (GO:0071872)3.63964030
58regulation of lipoprotein metabolic process (GO:0050746)3.60367088
59triglyceride metabolic process (GO:0006641)3.60070300
60negative regulation of granulocyte differentiation (GO:0030853)3.59630372
61dopaminergic neuron differentiation (GO:0071542)3.58409988
62regulation of extracellular matrix disassembly (GO:0010715)3.56300125
63triglyceride biosynthetic process (GO:0019432)3.55502867
64cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.52308231
65negative regulation of protein autophosphorylation (GO:0031953)3.51158749
66patterning of blood vessels (GO:0001569)3.50893625
67positive regulation of cellular response to insulin stimulus (GO:1900078)3.49816144
68regulation of cAMP-dependent protein kinase activity (GO:2000479)3.49315063
69cGMP-mediated signaling (GO:0019934)3.47228542
70stress fiber assembly (GO:0043149)3.46624725
71renal system process involved in regulation of blood volume (GO:0001977)3.45411684
72positive regulation of insulin receptor signaling pathway (GO:0046628)3.41876191
73neutral lipid biosynthetic process (GO:0046460)3.38139507
74acylglycerol biosynthetic process (GO:0046463)3.38139507
75acylglycerol metabolic process (GO:0006639)3.37326383
76diaphragm development (GO:0060539)3.36641607
77positive regulation of cholesterol efflux (GO:0010875)3.36359334
78positive regulation of protein kinase C signaling (GO:0090037)3.36244076
79protein heterotrimerization (GO:0070208)3.35346213
80positive regulation of histone deacetylation (GO:0031065)3.35056064
81lipid particle organization (GO:0034389)3.34823765
82myoblast fusion (GO:0007520)3.33545891
83neutral lipid metabolic process (GO:0006638)3.32243477
84regulation of gonadotropin secretion (GO:0032276)3.32108344
85white fat cell differentiation (GO:0050872)3.31385560
86regulation of alkaline phosphatase activity (GO:0010692)3.31041087
87fatty acid transmembrane transport (GO:1902001)3.30721863
88positive regulation of focal adhesion assembly (GO:0051894)3.28772822
89positive regulation of cell junction assembly (GO:1901890)3.28772822
90sprouting angiogenesis (GO:0002040)3.28336860
91branching involved in salivary gland morphogenesis (GO:0060445)3.28065725
92regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.27870475
93positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.26492549
94regulation of macrophage derived foam cell differentiation (GO:0010743)3.25990195
95negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.25410556
96triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.24424529
97regulation of Rac protein signal transduction (GO:0035020)3.23036822
98negative regulation of amino acid transport (GO:0051956)3.19434562
99regulation of vascular permeability (GO:0043114)3.19164970
100brown fat cell differentiation (GO:0050873)3.18718124
101positive regulation of adherens junction organization (GO:1903393)3.16827129
102oxaloacetate metabolic process (GO:0006107)3.16420180
103response to phenylpropanoid (GO:0080184)3.12608684
104positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.11369614
105excretion (GO:0007588)3.10573120
106protein localization to endosome (GO:0036010)3.09370760
107acylglycerol homeostasis (GO:0055090)3.08809243
108triglyceride homeostasis (GO:0070328)3.08809243
109epithelial cell-cell adhesion (GO:0090136)3.07716953
110negative regulation of macrophage differentiation (GO:0045650)3.07530483
111positive regulation of glucose import (GO:0046326)3.06503070
112lipoprotein transport (GO:0042953)3.06415071
113angiogenesis involved in wound healing (GO:0060055)3.04076952
114metanephric mesenchyme development (GO:0072075)3.03882291
115skeletal muscle organ development (GO:0060538)3.03838075
116lymph vessel development (GO:0001945)3.02820967
117negative regulation of platelet activation (GO:0010544)3.02575871
118response to epinephrine (GO:0071871)3.01567848
119glomerular visceral epithelial cell development (GO:0072015)23.5952299
120glomerular epithelial cell development (GO:0072310)20.9554591
121syncytium formation by plasma membrane fusion (GO:0000768)2.99799928
122regulation of apoptotic process involved in morphogenesis (GO:1902337)2.99716561
123glycerol metabolic process (GO:0006071)2.99520860
124negative regulation of smooth muscle cell migration (GO:0014912)2.99204413
125positive regulation of endothelial cell apoptotic process (GO:2000353)2.98500420
126endocrine hormone secretion (GO:0060986)2.97889137
127biotin metabolic process (GO:0006768)2.96067399
128barbed-end actin filament capping (GO:0051016)2.95984203
129blood vessel endothelial cell migration (GO:0043534)2.94441252
130regulation of corticosteroid hormone secretion (GO:2000846)2.94352108
131glomerular filtration (GO:0003094)2.93917535
132regulation of triglyceride catabolic process (GO:0010896)2.93373708
133positive regulation of glycolytic process (GO:0045821)2.92242102
134regulation of cell adhesion mediated by integrin (GO:0033628)2.90608413
135platelet-derived growth factor receptor signaling pathway (GO:0048008)2.90448513
136positive regulation of vasculogenesis (GO:2001214)2.90444899
137negative regulation of gluconeogenesis (GO:0045721)2.90007609
138positive regulation of sterol transport (GO:0032373)2.88798754
139positive regulation of cholesterol transport (GO:0032376)2.88798754
140T-helper 1 type immune response (GO:0042088)2.86997828
141cardiac muscle cell proliferation (GO:0060038)2.85182166
142metanephric epithelium development (GO:0072207)2.83521404
143ethanol metabolic process (GO:0006067)2.82500522
144apoptotic cell clearance (GO:0043277)2.81454018
145endothelial cell morphogenesis (GO:0001886)2.79539096
146CDP-diacylglycerol biosynthetic process (GO:0016024)2.77550581
147CDP-diacylglycerol metabolic process (GO:0046341)2.77227836
148ureteric bud development (GO:0001657)2.74995979
149negative regulation of DNA biosynthetic process (GO:2000279)2.74504062
150regulation of receptor binding (GO:1900120)2.73595280
151protein localization to cell surface (GO:0034394)2.73528475
152renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.73274227
153wound healing, spreading of cells (GO:0044319)2.70506007
154tricarboxylic acid metabolic process (GO:0072350)2.70175718
155negative regulation of blood vessel endothelial cell migration (GO:0043537)2.69888708
156positive regulation of glucose transport (GO:0010828)2.69774787
157syncytium formation (GO:0006949)2.69733846
158positive regulation of fatty acid metabolic process (GO:0045923)2.69435649
159negative regulation of smooth muscle cell proliferation (GO:0048662)2.69216343
160negative regulation of bone resorption (GO:0045779)2.68371166
161primary alcohol metabolic process (GO:0034308)2.66637670
162regulation of platelet aggregation (GO:0090330)2.65721858
163negative regulation of metanephros development (GO:0072217)2.65466607
164positive regulation of steroid hormone secretion (GO:2000833)2.64398427
165mesonephric tubule development (GO:0072164)2.63902319
166negative regulation of vascular permeability (GO:0043116)2.63637065
167mesonephric epithelium development (GO:0072163)2.62265517
168alditol metabolic process (GO:0019400)2.62199598
169regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.61925520
170basement membrane organization (GO:0071711)2.61166627
171morphogenesis of an epithelial sheet (GO:0002011)2.60880036
172positive regulation of urine volume (GO:0035810)2.59100802
173positive regulation of axon extension (GO:0045773)2.58698924
174regulation of excretion (GO:0044062)2.57964358
175regulation of sterol transport (GO:0032371)2.57621898
176regulation of cholesterol transport (GO:0032374)2.57621898
177regulation of cell proliferation involved in kidney development (GO:1901722)2.57325193
178negative regulation of organic acid transport (GO:0032891)2.57039732
179positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56874085
180endothelial cell migration (GO:0043542)2.56485551
181positive regulation of lipid catabolic process (GO:0050996)2.55916901
182mesodermal cell differentiation (GO:0048333)2.52154771
183cytoskeletal anchoring at plasma membrane (GO:0007016)2.51157803
184regulation of ruffle assembly (GO:1900027)2.51076418
185positive regulation of actin filament bundle assembly (GO:0032233)2.46806115
186positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.45463351
187positive regulation of mesonephros development (GO:0061213)2.43924379
188blood vessel remodeling (GO:0001974)2.42991722
189embryonic heart tube development (GO:0035050)2.41883368
190glomerular basement membrane development (GO:0032836)18.2200440
191glomerulus development (GO:0032835)11.6492347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.81686041
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.69534107
3CLOCK_20551151_ChIP-Seq_293T_Human3.26544909
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.16865900
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.11856993
6WT1_19549856_ChIP-ChIP_CCG9911_Human2.86912447
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.83738660
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.76972381
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.58191611
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58063165
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.42636836
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.34105872
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24639935
14* WT1_25993318_ChIP-Seq_PODOCYTE_Human2.23712369
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.22115291
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.14938406
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.13789194
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.12063974
19ZNF263_19887448_ChIP-Seq_K562_Human1.89536973
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87534205
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81684395
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76638739
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.74064796
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.74048245
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72411390
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71521387
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71521387
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.71425872
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.69429313
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65530820
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65519605
32* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64677060
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62863918
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62295399
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62135239
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60227803
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60103640
38KDM2B_26808549_Chip-Seq_K562_Human1.58267484
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.56002756
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51606501
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50222961
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.50134632
43PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.49585021
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48028589
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47970577
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46941976
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46801714
48AHR_22903824_ChIP-Seq_MCF-7_Human1.45907299
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44369867
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43783333
51* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42538921
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40423862
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40279685
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37667895
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37091705
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36819804
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34298785
58SMAD3_21741376_ChIP-Seq_HESCs_Human1.34142433
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32473968
60RXR_22108803_ChIP-Seq_LS180_Human1.30420370
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29778927
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29393613
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28904597
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27595648
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25532710
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25098239
67SOX2_20726797_ChIP-Seq_SW620_Human1.23226923
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.21026697
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.21026697
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.20314665
71CTCF_27219007_Chip-Seq_Bcells_Human1.19114893
72FOXA2_19822575_ChIP-Seq_HepG2_Human1.18172643
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.17700537
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17306134
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16354449
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15194030
77DROSHA_22980978_ChIP-Seq_HELA_Human1.14307760
78EZH2_22144423_ChIP-Seq_EOC_Human1.11213105
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.09642580
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09443191
81GATA1_22025678_ChIP-Seq_K562_Human1.09065044
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08719932
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07724338
84RACK7_27058665_Chip-Seq_MCF-7_Human1.06194018
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.05195370
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.04380208
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.04349506
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04291324
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03595365
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03001648
91CJUN_26792858_Chip-Seq_BT549_Human1.02505274
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01691644
93PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.01637949
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00861191
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00327235
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00123285
97* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99833437
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98639503
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98341984
100BRD4_25478319_ChIP-Seq_HGPS_Human0.97953717
101FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97236101
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97112863
103ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96681672
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96569601
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96315992
106* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96104033
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95497112
108SMC4_20622854_ChIP-Seq_HELA_Human0.95401909
109* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94916866
110GATA1_19941826_ChIP-Seq_K562_Human0.94027965
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.93526915
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93028888
113EZH2_27304074_Chip-Seq_ESCs_Mouse0.93023496
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.92597323
115GATA2_19941826_ChIP-Seq_K562_Human0.92417465
116PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91814780
117LXR_22158963_ChIP-Seq_LIVER_Mouse0.91655821
118MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91639110
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91579099
120* LXR_22292898_ChIP-Seq_THP-1_Human0.91574675
121P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91424472
122JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91393701
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90353605
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89520905
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89262194
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88875757
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.88548143
128KDM2B_26808549_Chip-Seq_DND41_Human0.87602129
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87153407
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86832274
131* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86433070
132P68_20966046_ChIP-Seq_HELA_Human0.85984844
133KLF4_19829295_ChIP-Seq_ESCs_Human0.85540331
134* SA1_22415368_ChIP-Seq_MEFs_Mouse0.83098552
135* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82844478
136MYC_27129775_Chip-Seq_CORNEA_Mouse0.82430963
137KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82304823
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80667909
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80667909
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80667909
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79706563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology5.91135401
2MP0010368_abnormal_lymphatic_system5.24862973
3MP0004272_abnormal_basement_membrane5.16370516
4MP0004084_abnormal_cardiac_muscle4.98250298
5MP0001879_abnormal_lymphatic_vessel4.52764339
6MP0005167_abnormal_blood-brain_barrier3.62228189
7MP0002971_abnormal_brown_adipose3.55581110
8MP0004036_abnormal_muscle_relaxation3.20144926
9MP0001661_extended_life_span2.82560811
10MP0010329_abnormal_lipoprotein_level2.72763647
11MP0009115_abnormal_fat_cell2.69909464
12MP0000537_abnormal_urethra_morphology2.62665357
13MP0000751_myopathy2.57102592
14MP0000230_abnormal_systemic_arterial2.41942091
15MP0002136_abnormal_kidney_physiology2.41555763
16MP0009643_abnormal_urine_homeostasis2.36824344
17MP0005275_abnormal_skin_tensile2.31885279
18MP0010030_abnormal_orbit_morphology2.26200066
19MP0002135_abnormal_kidney_morphology2.23840654
20MP0005332_abnormal_amino_acid2.17551661
21MP0003959_abnormal_lean_body2.13089817
22MP0002876_abnormal_thyroid_physiology2.09147982
23MP0008438_abnormal_cutaneous_collagen2.08461950
24MP0003942_abnormal_urinary_system2.07193708
25MP0000534_abnormal_ureter_morphology2.06473501
26MP0009384_cardiac_valve_regurgitation1.97408685
27MP0002970_abnormal_white_adipose1.96157154
28MP0005334_abnormal_fat_pad1.92714880
29MP0003724_increased_susceptibility_to1.87224847
30MP0005535_abnormal_body_temperature1.83605185
31MP0002295_abnormal_pulmonary_circulatio1.82135100
32MP0000013_abnormal_adipose_tissue1.76960649
33MP0003868_abnormal_feces_composition1.76550580
34MP0005503_abnormal_tendon_morphology1.71317464
35MP0008775_abnormal_heart_ventricle1.70302068
36MP0005409_darkened_coat_color1.69958555
37MP0001756_abnormal_urination1.67247976
38MP0002108_abnormal_muscle_morphology1.65205586
39MP0003566_abnormal_cell_adhesion1.64179144
40MP0008961_abnormal_basal_metabolism1.61629396
41MP0002118_abnormal_lipid_homeostasis1.60959342
42MP0003011_delayed_dark_adaptation1.59972895
43MP0006138_congestive_heart_failure1.56597822
44MP0005448_abnormal_energy_balance1.54590159
45MP0004185_abnormal_adipocyte_glucose1.51862804
46MP0002128_abnormal_blood_circulation1.48092423
47MP0003283_abnormal_digestive_organ1.47923849
48MP0000678_abnormal_parathyroid_gland1.45762223
49MP0005197_abnormal_uvea_morphology1.41244644
50MP0003091_abnormal_cell_migration1.40812445
51MP0005360_urolithiasis1.38185222
52MP0000767_abnormal_smooth_muscle1.34938666
53MP0004215_abnormal_myocardial_fiber1.30487191
54MP0001614_abnormal_blood_vessel1.29518364
55MP0003941_abnormal_skin_development1.29366487
56MP0001915_intracranial_hemorrhage1.27705888
57MP0001544_abnormal_cardiovascular_syste1.26222563
58MP0005385_cardiovascular_system_phenoty1.26222563
59MP0005187_abnormal_penis_morphology1.25867336
60MP0003950_abnormal_plasma_membrane1.25847233
61MP0002933_joint_inflammation1.25357998
62MP0000747_muscle_weakness1.23986086
63MP0002638_abnormal_pupillary_reflex1.19635571
64MP0003828_pulmonary_edema1.16797846
65MP0001958_emphysema1.16244508
66MP0000003_abnormal_adipose_tissue1.15707585
67MP0000759_abnormal_skeletal_muscle1.14606957
68MP0005452_abnormal_adipose_tissue1.13621104
69MP0003279_aneurysm1.12910388
70MP0001784_abnormal_fluid_regulation1.12818036
71MP0002972_abnormal_cardiac_muscle1.12053303
72MP0003186_abnormal_redox_activity1.09161785
73MP0010307_abnormal_tumor_latency1.08562254
74MP0003705_abnormal_hypodermis_morpholog1.08490858
75MP0004233_abnormal_muscle_weight1.06269083
76MP0003300_gastrointestinal_ulcer1.05879668
77MP0002909_abnormal_adrenal_gland1.05329933
78MP0000579_abnormal_nail_morphology1.04714799
79MP0005365_abnormal_bile_salt1.04672722
80MP0003191_abnormal_cellular_cholesterol1.03184439
81MP0005165_increased_susceptibility_to1.02789855
82MP0002925_abnormal_cardiovascular_devel1.01314301
83MP0000749_muscle_degeneration1.01088952
84MP0003303_peritoneal_inflammation1.00841890
85MP0002078_abnormal_glucose_homeostasis0.98659675
86MP0001501_abnormal_sleep_pattern0.98631193
87MP0005620_abnormal_muscle_contractility0.95511045
88MP0003948_abnormal_gas_homeostasis0.95152767
89MP0005595_abnormal_vascular_smooth0.94714245
90MP0003115_abnormal_respiratory_system0.93646075
91MP0005375_adipose_tissue_phenotype0.90400315
92MP0010630_abnormal_cardiac_muscle0.90157475
93MP0004130_abnormal_muscle_cell0.89937658
94MP0002138_abnormal_hepatobiliary_system0.89815122
95MP0000343_altered_response_to0.89523282
96MP0004484_altered_response_of0.87980737
97MP0002090_abnormal_vision0.86201836
98MP0005670_abnormal_white_adipose0.86069314
99MP0005379_endocrine/exocrine_gland_phen0.85748239
100MP0005647_abnormal_sex_gland0.84726646
101MP0000163_abnormal_cartilage_morphology0.81542393
102MP0005666_abnormal_adipose_tissue0.81087507
103MP0004859_abnormal_synaptic_plasticity0.80827432
104MP0002998_abnormal_bone_remodeling0.80766843
105MP0005164_abnormal_response_to0.80393924
106MP0004782_abnormal_surfactant_physiolog0.79276757
107MP0005193_abnormal_anterior_eye0.78781630
108MP0003879_abnormal_hair_cell0.78345823
109MP0005584_abnormal_enzyme/coenzyme_acti0.77240811
110MP0003937_abnormal_limbs/digits/tail_de0.76871494
111MP0005369_muscle_phenotype0.76407145
112MP0002796_impaired_skin_barrier0.76210538
113MP0000858_altered_metastatic_potential0.75525965
114MP0000609_abnormal_liver_physiology0.75525842
115MP0003935_abnormal_craniofacial_develop0.74621818
116MP0003075_altered_response_to0.72590763
117MP0001764_abnormal_homeostasis0.70810203
118MP0004858_abnormal_nervous_system0.67203582
119MP0001346_abnormal_lacrimal_gland0.65832303
120MP0004087_abnormal_muscle_fiber0.63946601
121MP0002269_muscular_atrophy0.62277421
122MP0003252_abnormal_bile_duct0.61972799
123MP0001175_abnormal_lung_morphology0.61907043
124MP0002932_abnormal_joint_morphology0.61900371
125MP0010386_abnormal_urinary_bladder0.61289376
126MP0000516_abnormal_urinary_system0.61168853
127MP0005367_renal/urinary_system_phenotyp0.61168853
128MP0001851_eye_inflammation0.60865784
129MP0006036_abnormal_mitochondrial_physio0.60259155
130MP0002896_abnormal_bone_mineralization0.60150301
131MP0002115_abnormal_skeleton_extremities0.59975594
132MP0005508_abnormal_skeleton_morphology0.59644583
133MP0001324_abnormal_eye_pigmentation0.59047027
134MP0003690_abnormal_glial_cell0.58941079
135MP0000266_abnormal_heart_morphology0.58899554
136MP0001765_abnormal_ion_homeostasis0.58776094
137MP0005058_abnormal_lysosome_morphology0.56993363
138MP0001727_abnormal_embryo_implantation0.56637327
139MP0001286_abnormal_eye_development0.56389331
140MP0005166_decreased_susceptibility_to0.56360271
141MP0005451_abnormal_body_composition0.56222010
142MP0005330_cardiomyopathy0.56042146
143MP0003385_abnormal_body_wall0.55874470
144MP0002106_abnormal_muscle_physiology0.55381291
145MP0000249_abnormal_blood_vessel0.55318734
146MP0002133_abnormal_respiratory_system0.55300481
147MP0005388_respiratory_system_phenotype0.55300481
148MP0002113_abnormal_skeleton_development0.55180808
149MP0009780_abnormal_chondrocyte_physiolo0.54984756
150MP0003953_abnormal_hormone_level0.54944120
151MP0006276_abnormal_autonomic_nervous0.54563215
152MP0000477_abnormal_intestine_morphology0.53335925
153MP0001881_abnormal_mammary_gland0.52848932

Predicted human phenotypes

RankGene SetZ-score
1Hypoalbuminemia (HP:0003073)9.50155264
2Abnormal albumin level (HP:0012116)9.50155264
3Glomerulosclerosis (HP:0000096)8.97244841
4Nephritis (HP:0000123)6.71987670
5Glomerulonephritis (HP:0000099)6.41531828
6Stage 5 chronic kidney disease (HP:0003774)6.19122614
7Oligomenorrhea (HP:0000876)6.01105995
8Tubular atrophy (HP:0000092)5.52946467
9Acanthosis nigricans (HP:0000956)5.35170389
10Hypertriglyceridemia (HP:0002155)5.20844951
11Hypoproteinemia (HP:0003075)5.10617828
12Nephrotic syndrome (HP:0000100)4.95207019
13Neonatal respiratory distress (HP:0002643)4.91131331
14Increased variability in muscle fiber diameter (HP:0003557)4.58374734
15Protrusio acetabuli (HP:0003179)4.55088330
16Muscle fiber splitting (HP:0003555)4.42695229
17Metaphyseal dysplasia (HP:0100255)4.40153829
18Rapidly progressive (HP:0003678)4.29911094
19Hemorrhage of the eye (HP:0011885)4.12364596
20Abnormality of skeletal muscle fiber size (HP:0012084)4.05443162
21Difficulty running (HP:0009046)4.00404192
22Lymphangioma (HP:0100764)3.95549205
23Proteinuria (HP:0000093)3.85779506
24Increased connective tissue (HP:0009025)3.83029254
25Corneal erosion (HP:0200020)3.73513305
26Complement deficiency (HP:0004431)3.56668380
27Insulin resistance (HP:0000855)3.42835552
28Myocardial infarction (HP:0001658)3.41902487
29Nonprogressive disorder (HP:0003680)3.40599374
30Spinal rigidity (HP:0003306)3.29288513
31Hematuria (HP:0000790)3.25412537
32Skin nodule (HP:0200036)3.25096410
33Pigmentary retinal degeneration (HP:0001146)3.22965775
34Deep venous thrombosis (HP:0002625)3.15490408
35Hyperlipoproteinemia (HP:0010980)3.15252195
36Tubulointerstitial fibrosis (HP:0005576)3.10521828
37Increased circulating renin level (HP:0000848)3.09261366
38Abnormality of complement system (HP:0005339)3.08344121
39Metaphyseal cupping (HP:0003021)3.06924168
40Xanthomatosis (HP:0000991)2.96445006
41Abnormal tarsal ossification (HP:0008369)2.90603555
42Systemic lupus erythematosus (HP:0002725)2.90107961
43Visceral angiomatosis (HP:0100761)2.88432121
44Epidermoid cyst (HP:0200040)2.85146343
45Polar cataract (HP:0010696)2.83414976
46Hypercholesterolemia (HP:0003124)2.81189590
47Hypokalemic alkalosis (HP:0001949)2.79517251
48Growth hormone excess (HP:0000845)2.78054900
49Abnormal eating behavior (HP:0100738)2.74807165
50Back pain (HP:0003418)2.69330427
51Hemangiomatosis (HP:0007461)2.66116858
52Hyporeflexia of lower limbs (HP:0002600)2.64853413
53Asymmetric septal hypertrophy (HP:0001670)2.62760406
54Hematochezia (HP:0002573)2.62625118
55Persistence of primary teeth (HP:0006335)2.62337353
56Hypercortisolism (HP:0001578)2.61553339
57Axonal loss (HP:0003447)2.60236170
58Exercise-induced myalgia (HP:0003738)2.58471870
59Joint hemorrhage (HP:0005261)2.56847636
60Neck muscle weakness (HP:0000467)2.54620770
61Ridged nail (HP:0001807)2.52683228
62Vertebral compression fractures (HP:0002953)2.51590394
63Insulin-resistant diabetes mellitus (HP:0000831)2.50118932
64Bone cyst (HP:0012062)2.48612202
65Subcapsular cataract (HP:0000523)2.46679402
66Retinal atrophy (HP:0001105)2.46621562
67Type 1 muscle fiber predominance (HP:0003803)2.45885657
68Ectopia lentis (HP:0001083)2.45750281
69Amyloidosis (HP:0011034)2.44623538
70Pterygium (HP:0001059)2.42997963
71Aplasia of the musculature (HP:0100854)2.41631384
72Polycythemia (HP:0001901)2.40144640
73Coronal craniosynostosis (HP:0004440)2.39763160
74Autoimmune thrombocytopenia (HP:0001973)2.35403952
75Myotonia (HP:0002486)2.34814116
76Frequent falls (HP:0002359)2.32180709
77Down-sloping shoulders (HP:0200021)2.31820232
78Vascular tortuosity (HP:0004948)2.30432767
79Colitis (HP:0002583)2.28729201
80Interstitial pulmonary disease (HP:0006530)2.27002030
81Hypomagnesemia (HP:0002917)2.24616116
82Ileus (HP:0002595)2.22939119
83Atrioventricular block (HP:0001678)2.21049651
84Lipoatrophy (HP:0100578)2.20843838
85Striae distensae (HP:0001065)2.20097930
86Hip contracture (HP:0003273)2.18726235
87Reduced subcutaneous adipose tissue (HP:0003758)2.16864731
88Aortic aneurysm (HP:0004942)2.16720635
89Concave nail (HP:0001598)2.16273907
90Venous insufficiency (HP:0005293)2.15699385
91Abnormality of the pulmonary veins (HP:0011718)2.15572074
92Prominent supraorbital ridges (HP:0000336)2.11730689
93Ankle contracture (HP:0006466)2.11691393
94Obstructive sleep apnea (HP:0002870)2.11028328
95Facial shape deformation (HP:0011334)2.10583568
96Potter facies (HP:0002009)2.10583568
97Hypophosphatemia (HP:0002148)2.09597615
98Abnormality of the fingertips (HP:0001211)2.08287202
99Easy fatigability (HP:0003388)2.07904948
100Mildly elevated creatine phosphokinase (HP:0008180)2.06495088
101Arterial tortuosity (HP:0005116)2.05769538
102Anomalous pulmonary venous return (HP:0010772)2.05707568
103Bulbar palsy (HP:0001283)2.05355682
104Abnormal foot bone ossification (HP:0010675)2.04603015
105Wormian bones (HP:0002645)2.01848134
106Delayed epiphyseal ossification (HP:0002663)2.00972453
107Mesangial abnormality (HP:0001966)13.1954232
108Focal segmental glomerulosclerosis (HP:0000097)11.4960877
109Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.99640169
110Hyperactive renin-angiotensin system (HP:0000841)1.97442906
111Hypoparathyroidism (HP:0000829)1.97139213
112Cervical subluxation (HP:0003308)1.96700811
113Gowers sign (HP:0003391)1.96577341
114Nausea (HP:0002018)1.96406140
115Foot dorsiflexor weakness (HP:0009027)1.96066170
116Accelerated skeletal maturation (HP:0005616)1.92891869
117Germ cell neoplasia (HP:0100728)1.90186105
118Muscle stiffness (HP:0003552)1.89928128
119Hypoalphalipoproteinemia (HP:0003233)1.89342583
120Abnormal atrioventricular conduction (HP:0005150)1.89224108
121Abnormality of the periventricular white matter (HP:0002518)1.88927051
122Shawl scrotum (HP:0000049)1.87866667
123Rhabdomyolysis (HP:0003201)1.87077038
124Cavernous hemangioma (HP:0001048)1.85655017
125Mitral valve prolapse (HP:0001634)1.85072854
126Nonimmune hydrops fetalis (HP:0001790)1.83551364
127Premature rupture of membranes (HP:0001788)1.83292425
128Polygenic inheritance (HP:0010982)1.81940900
129Broad metatarsal (HP:0001783)1.81723168
130Venous abnormality (HP:0002624)1.81316560
131Exostoses (HP:0100777)1.80535171
132Abnormality of magnesium homeostasis (HP:0004921)1.80153222
133Abnormality of the foot musculature (HP:0001436)1.78585317
134Choanal stenosis (HP:0000452)1.77292564
135Chondrocalcinosis (HP:0000934)1.76006761
136Heart block (HP:0012722)1.75941142
137Distal lower limb amyotrophy (HP:0008944)1.75025375
138Wide cranial sutures (HP:0010537)1.72349321
139Stroke (HP:0001297)1.70683785
140Abnormality of renin-angiotensin system (HP:0000847)1.69627282
141Coxa vara (HP:0002812)1.69626967
142Cerebral aneurysm (HP:0004944)1.69331514
143Nephrocalcinosis (HP:0000121)1.68910354
144Hypoplastic left heart (HP:0004383)1.68501664
145Aneurysm (HP:0002617)1.68247763
146Bronchomalacia (HP:0002780)1.67171007
147Abnormality of proline metabolism (HP:0010907)1.66502831
148Hydroxyprolinuria (HP:0003080)1.66502831
149Prolonged bleeding time (HP:0003010)1.65712918
150Aqueductal stenosis (HP:0002410)1.64857520
151Distal lower limb muscle weakness (HP:0009053)1.64535588
152Large hands (HP:0001176)1.64508994
153Abnormality of chloride homeostasis (HP:0011422)1.63596975
154Tubulointerstitial abnormality (HP:0001969)1.62856569
155Abdominal distention (HP:0003270)1.62062054
156Spontaneous hematomas (HP:0007420)1.61948618
157Abnormality of Sharpey fibers (HP:0100685)1.61460027
158Renal duplication (HP:0000075)1.60946084
159Cerebral hemorrhage (HP:0001342)1.60181939
160Abnormality of calcium-phosphate metabolism (HP:0100530)1.59909869
161Tetany (HP:0001281)1.59371561
162Rectal prolapse (HP:0002035)1.59280080
163Knee flexion contracture (HP:0006380)1.58782707
164Recurrent corneal erosions (HP:0000495)1.57744294
165Hypoplasia of the iris (HP:0007676)1.55018530
166Abnormality of the peritoneum (HP:0002585)1.54787365
167Limited hip movement (HP:0008800)1.53375681
168Advanced eruption of teeth (HP:0006288)1.52487880
169Absent phalangeal crease (HP:0006109)1.52168433
170Turricephaly (HP:0000262)1.51980598
171Glomerulopathy (HP:0100820)1.50350790
172Hypercalciuria (HP:0002150)1.47564840
173Testicular neoplasm (HP:0010788)1.47031124
174Abnormality of carpal bone ossification (HP:0006257)1.42364755
175Esophageal varix (HP:0002040)1.37184177
176Abnormality of the nasal mucosa (HP:0000433)1.36503768
177Hypokalemia (HP:0002900)1.34103822
178Sensorimotor neuropathy (HP:0007141)1.28704044
179Exotropia (HP:0000577)1.28591194
180Shallow orbits (HP:0000586)1.28004345
181Increased CSF protein (HP:0002922)1.27422943
182Seborrheic dermatitis (HP:0001051)1.27329405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.89064083
2TIE15.48228492
3EPHB25.11316813
4OXSR14.45456963
5PAK44.41137951
6STK394.16522637
7MYLK3.08235168
8TGFBR22.91323703
9DDR22.65847154
10TRIB32.35688555
11PRKAA22.32588158
12EEF2K2.28894113
13KDR2.22452955
14EPHB12.19954136
15TESK11.78634427
16CAMK11.76027733
17MAP3K61.73424115
18FGFR41.48734639
19LATS11.44300816
20MAPKAPK31.39057105
21FER1.35835876
22MAP3K71.32021121
23MAPK41.30260165
24TGFBR11.28075921
25MAPK151.24149811
26CDK191.23174702
27PDGFRA1.22742381
28ERN11.20443046
29GRK51.16871286
30CAMK2B1.16487606
31RIPK11.16304607
32ROCK11.12417178
33PTK61.12213981
34LRRK21.10685453
35NTRK11.06479777
36OBSCN1.05804985
37PTK2B1.04747662
38ICK1.02090288
39FGFR21.01074972
40ARAF1.00995905
41MST40.98562746
42WNK10.96847018
43PRKAA10.95819702
44SIK10.95781767
45NME10.94361903
46PAK20.92590461
47GRK10.91731015
48PRKCH0.91224900
49PAK30.90290942
50PRPF4B0.88230931
51CDC42BPA0.87877989
52TTN0.86820684
53GSK3A0.86737091
54MAPK70.86123204
55MAP2K10.82876680
56LATS20.81088340
57CDK60.80115887
58MOS0.76304224
59TSSK60.73948558
60PRKD30.73583403
61RIPK40.72789362
62PDPK10.65827965
63DAPK20.65739910
64JAK10.65059140
65TYRO30.63343057
66PRKG20.63088972
67PTK20.62393245
68DMPK0.61224271
69NLK0.57253589
70PRKG10.57158296
71BMX0.56921087
72PRKD10.56274494
73STK100.54315986
74JAK20.53684228
75FGFR30.53620483
76NEK90.52461277
77PRKCE0.51656034
78CAMK1G0.51454990
79PDK20.50603021
80PDGFRB0.49710332
81MAP2K30.48415793
82MAPKAPK50.48398635
83MAPK90.48014229
84RPS6KA20.47669406
85PIK3CA0.47656413
86SGK4940.47305754
87SGK2230.47305754
88TYK20.46783140
89SRC0.46716805
90ABL20.46492064
91PHKG10.46289757
92PHKG20.46289757
93FES0.45473375
94KSR20.45309493
95CAMK1D0.45071805
96STK380.44632644
97FGFR10.44526612
98MAPK30.44097577
99MARK20.43629499
100ZAP700.42589835
101SGK20.42288164
102MARK10.41895730
103PRKD20.41412293
104MAP3K130.41057926
105KIT0.40838504
106RPS6KA30.40835973
107CSK0.39986794
108PKN10.39836302
109MAPK120.39506435
110MTOR0.39502584
111PKN20.39476217
112CDK150.37578716
113MAP3K110.37035887
114STK38L0.36823480
115DAPK30.36407990
116DYRK1B0.35759703
117IGF1R0.35611821
118FYN0.35314556
119CDK90.35153294
120CDK140.35127381
121TBK10.33852150
122CDK11A0.33105468
123EPHA30.32832286
124NEK10.32671278
125NTRK30.32551715
126CDK180.32372307
127PDK10.31761920
128MAP3K30.29976912
129MAP3K20.28381252
130PRKACG0.26014998
131PAK60.25831351
132CDK50.25351524
133ROCK20.24981890
134RET0.24601881
135MAP3K10.24219589
136LMTK20.23708039
137EGFR0.23608818
138SGK30.23221692
139TRPM70.22172572
140EPHA20.21708003

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.39804503
2Renin-angiotensin system_Homo sapiens_hsa046143.93200760
3Phenylalanine metabolism_Homo sapiens_hsa003603.19582884
4Small cell lung cancer_Homo sapiens_hsa052222.73857205
5Focal adhesion_Homo sapiens_hsa045102.71024137
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.70595280
7Glycerolipid metabolism_Homo sapiens_hsa005612.65572406
8Fatty acid biosynthesis_Homo sapiens_hsa000612.64289767
9Protein digestion and absorption_Homo sapiens_hsa049742.59046226
10Amoebiasis_Homo sapiens_hsa051462.46994553
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.38540760
12Histidine metabolism_Homo sapiens_hsa003402.29865864
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.26764908
14Fat digestion and absorption_Homo sapiens_hsa049752.14268114
15Dilated cardiomyopathy_Homo sapiens_hsa054142.01434691
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01342439
17* Axon guidance_Homo sapiens_hsa043601.89329019
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.87183310
19Tyrosine metabolism_Homo sapiens_hsa003501.83680739
20Pyruvate metabolism_Homo sapiens_hsa006201.70970276
21N-Glycan biosynthesis_Homo sapiens_hsa005101.65645935
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.62348579
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59285990
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55026817
25beta-Alanine metabolism_Homo sapiens_hsa004101.54209530
26Proteoglycans in cancer_Homo sapiens_hsa052051.50633406
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49211499
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.47974638
29Fatty acid elongation_Homo sapiens_hsa000621.45507638
30Renal cell carcinoma_Homo sapiens_hsa052111.38158085
31Bladder cancer_Homo sapiens_hsa052191.33601124
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29595421
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29273943
34Vitamin digestion and absorption_Homo sapiens_hsa049771.27178140
35Adherens junction_Homo sapiens_hsa045201.24071841
36PI3K-Akt signaling pathway_Homo sapiens_hsa041511.22958199
37Renin secretion_Homo sapiens_hsa049241.21526351
38Tryptophan metabolism_Homo sapiens_hsa003801.20838363
39Rap1 signaling pathway_Homo sapiens_hsa040151.17755447
40Insulin signaling pathway_Homo sapiens_hsa049101.16368218
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15970771
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.15126373
43VEGF signaling pathway_Homo sapiens_hsa043701.14514607
44Tight junction_Homo sapiens_hsa045301.11316043
45Complement and coagulation cascades_Homo sapiens_hsa046101.10058382
46Pancreatic cancer_Homo sapiens_hsa052121.07285564
47Ovarian steroidogenesis_Homo sapiens_hsa049131.04377154
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01945236
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.01081543
50Platelet activation_Homo sapiens_hsa046111.00469201
51Gastric acid secretion_Homo sapiens_hsa049710.98241640
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98106037
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97897806
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.97647349
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.97043316
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91231300
57Dorso-ventral axis formation_Homo sapiens_hsa043200.89689080
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.86191848
59Pathways in cancer_Homo sapiens_hsa052000.86097240
60mTOR signaling pathway_Homo sapiens_hsa041500.85743765
61Hippo signaling pathway_Homo sapiens_hsa043900.84240381
62Arginine and proline metabolism_Homo sapiens_hsa003300.84191368
63Viral myocarditis_Homo sapiens_hsa054160.81703664
64Glucagon signaling pathway_Homo sapiens_hsa049220.81679404
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81252186
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80886201
67Fatty acid degradation_Homo sapiens_hsa000710.79985188
68Nitrogen metabolism_Homo sapiens_hsa009100.78018876
69Thyroid hormone synthesis_Homo sapiens_hsa049180.76746707
70Prion diseases_Homo sapiens_hsa050200.74820727
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73523142
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72899246
73Malaria_Homo sapiens_hsa051440.72382010
74Propanoate metabolism_Homo sapiens_hsa006400.70926446
75Bile secretion_Homo sapiens_hsa049760.69740521
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69582658
77Endocytosis_Homo sapiens_hsa041440.68449174
78Lysine degradation_Homo sapiens_hsa003100.66772867
79Gap junction_Homo sapiens_hsa045400.66708079
80PPAR signaling pathway_Homo sapiens_hsa033200.66529245
81cAMP signaling pathway_Homo sapiens_hsa040240.65762686
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65214567
83Retinol metabolism_Homo sapiens_hsa008300.64437636
84Insulin resistance_Homo sapiens_hsa049310.64278756
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63367202
86Ras signaling pathway_Homo sapiens_hsa040140.61422481
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.61209833
88GnRH signaling pathway_Homo sapiens_hsa049120.58830652
89Estrogen signaling pathway_Homo sapiens_hsa049150.58504813
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58215240
91Fatty acid metabolism_Homo sapiens_hsa012120.57640760
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57498839
93Other glycan degradation_Homo sapiens_hsa005110.56789320
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56129701
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.55633509
96Lysosome_Homo sapiens_hsa041420.55423589
97Starch and sucrose metabolism_Homo sapiens_hsa005000.55421318
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53876422
99Phagosome_Homo sapiens_hsa041450.51528361
100Carbon metabolism_Homo sapiens_hsa012000.51154797
101Notch signaling pathway_Homo sapiens_hsa043300.50887884
102Salivary secretion_Homo sapiens_hsa049700.50522498
103Oxytocin signaling pathway_Homo sapiens_hsa049210.50142060
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48962144
105HIF-1 signaling pathway_Homo sapiens_hsa040660.47797415
106Circadian rhythm_Homo sapiens_hsa047100.47267635
107MicroRNAs in cancer_Homo sapiens_hsa052060.46732068
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45185778
109Glioma_Homo sapiens_hsa052140.45035519
110Sulfur relay system_Homo sapiens_hsa041220.43460859
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41392219
112Staphylococcus aureus infection_Homo sapiens_hsa051500.41365925
113Acute myeloid leukemia_Homo sapiens_hsa052210.41352319
114Prostate cancer_Homo sapiens_hsa052150.38785875
115Chronic myeloid leukemia_Homo sapiens_hsa052200.38707643
116Fructose and mannose metabolism_Homo sapiens_hsa000510.38613195
117Vitamin B6 metabolism_Homo sapiens_hsa007500.38419938
118Type II diabetes mellitus_Homo sapiens_hsa049300.37826589
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36487207
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35838907
121Arginine biosynthesis_Homo sapiens_hsa002200.35814719
122Chemical carcinogenesis_Homo sapiens_hsa052040.35503821
123Sphingolipid metabolism_Homo sapiens_hsa006000.35033247
124Rheumatoid arthritis_Homo sapiens_hsa053230.34808370
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34711501
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34377512
127Toxoplasmosis_Homo sapiens_hsa051450.34369575
128Insulin secretion_Homo sapiens_hsa049110.32152627
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31719286
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30300526
131Melanogenesis_Homo sapiens_hsa049160.30250979
132Long-term potentiation_Homo sapiens_hsa047200.30001747
133Non-small cell lung cancer_Homo sapiens_hsa052230.29603107
134Cocaine addiction_Homo sapiens_hsa050300.29349650
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29215648
136ABC transporters_Homo sapiens_hsa020100.28124096
137Morphine addiction_Homo sapiens_hsa050320.27877555
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27385146
139Salmonella infection_Homo sapiens_hsa051320.26669523
140AMPK signaling pathway_Homo sapiens_hsa041520.26550047
141Butanoate metabolism_Homo sapiens_hsa006500.25502348
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24415144
143Circadian entrainment_Homo sapiens_hsa047130.23258506
144TGF-beta signaling pathway_Homo sapiens_hsa043500.23242031

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »