SEMA4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.52214878
2modulation by symbiont of host defense response (GO:0052031)5.52214878
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.52214878
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.52214878
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.52214878
6modulation by symbiont of host immune response (GO:0052553)5.52214878
7response to peptidoglycan (GO:0032494)5.25886735
8regulation of cholesterol esterification (GO:0010872)5.20410842
9neutrophil activation involved in immune response (GO:0002283)5.02728787
10macrophage activation involved in immune response (GO:0002281)4.96512404
11detection of other organism (GO:0098543)4.76835914
12negative regulation of interleukin-12 production (GO:0032695)4.75768820
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71553982
14detection of bacterium (GO:0016045)4.60476388
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.52764082
16immunoglobulin mediated immune response (GO:0016064)4.48527629
17regulation of B cell receptor signaling pathway (GO:0050855)4.30349629
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.25003233
19L-phenylalanine catabolic process (GO:0006559)4.25003233
20indole-containing compound catabolic process (GO:0042436)4.23151955
21indolalkylamine catabolic process (GO:0046218)4.23151955
22tryptophan catabolic process (GO:0006569)4.23151955
23aromatic amino acid family catabolic process (GO:0009074)4.20957322
24detection of external biotic stimulus (GO:0098581)4.12948560
25cellular extravasation (GO:0045123)4.12688524
26detection of molecule of bacterial origin (GO:0032490)4.12430667
27sulfur amino acid catabolic process (GO:0000098)4.10514567
28L-phenylalanine metabolic process (GO:0006558)4.02146124
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.02146124
30kynurenine metabolic process (GO:0070189)4.00757148
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.00121592
32regulation of interferon-beta biosynthetic process (GO:0045357)3.99247838
33high-density lipoprotein particle remodeling (GO:0034375)3.96632262
34regulation of gamma-delta T cell activation (GO:0046643)3.96585529
35phospholipid efflux (GO:0033700)3.93065712
36response to host immune response (GO:0052572)3.88566344
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.88566344
38tryptophan metabolic process (GO:0006568)3.88007724
39alpha-linolenic acid metabolic process (GO:0036109)3.83986048
40respiratory burst (GO:0045730)3.79526932
41urea metabolic process (GO:0019627)3.77731032
42urea cycle (GO:0000050)3.77731032
43germinal center formation (GO:0002467)3.77136436
44neutrophil activation (GO:0042119)3.71696867
45reverse cholesterol transport (GO:0043691)3.67916445
46regulation of mast cell degranulation (GO:0043304)3.67438281
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66818443
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66818443
49cellular response to type I interferon (GO:0071357)3.64747969
50type I interferon signaling pathway (GO:0060337)3.64747969
51microglial cell activation (GO:0001774)3.64207433
52myeloid cell activation involved in immune response (GO:0002275)3.63896996
53detection of biotic stimulus (GO:0009595)3.63513423
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.62724720
55negative regulation of sterol transport (GO:0032372)3.61977734
56negative regulation of cholesterol transport (GO:0032375)3.61977734
57response to type I interferon (GO:0034340)3.61760940
58interferon-gamma-mediated signaling pathway (GO:0060333)3.61451822
59granulocyte activation (GO:0036230)3.60563585
60response to muramyl dipeptide (GO:0032495)3.59227170
61regulation of triglyceride catabolic process (GO:0010896)3.59161583
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.56248411
63macrophage activation (GO:0042116)3.55718688
64protein-lipid complex remodeling (GO:0034368)3.55377483
65macromolecular complex remodeling (GO:0034367)3.55377483
66plasma lipoprotein particle remodeling (GO:0034369)3.55377483
67B cell receptor signaling pathway (GO:0050853)3.54497002
68negative regulation of lymphocyte mediated immunity (GO:0002707)3.53180305
69regulation of dendritic cell antigen processing and presentation (GO:0002604)3.51551258
70response to host (GO:0075136)3.50717958
71response to host defenses (GO:0052200)3.50717958
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.50717958
73cysteine metabolic process (GO:0006534)3.50644836
74complement activation, alternative pathway (GO:0006957)3.48525417
75B cell mediated immunity (GO:0019724)3.48420897
76glyoxylate metabolic process (GO:0046487)3.44745647
77lipopolysaccharide-mediated signaling pathway (GO:0031663)3.44364960
78antigen processing and presentation of endogenous antigen (GO:0019883)3.43288359
79nitrogen cycle metabolic process (GO:0071941)3.42832427
80defense response to protozoan (GO:0042832)3.41247904
81peptidyl-glutamic acid carboxylation (GO:0017187)3.39554445
82protein carboxylation (GO:0018214)3.39554445
83regulation of mast cell activation involved in immune response (GO:0033006)3.37439207
84negative regulation of T cell mediated immunity (GO:0002710)3.33687792
85negative regulation of leukocyte mediated immunity (GO:0002704)3.33471369
86negative regulation of erythrocyte differentiation (GO:0045647)3.33390127
87bile acid biosynthetic process (GO:0006699)3.33098841
88positive regulation of mast cell activation (GO:0033005)3.30551557
89regulation of myeloid leukocyte mediated immunity (GO:0002886)3.28213362
90plasma lipoprotein particle assembly (GO:0034377)3.27197464
91regulation of leukocyte degranulation (GO:0043300)3.26249763
92phospholipid homeostasis (GO:0055091)3.25562826
93regulation of antigen processing and presentation (GO:0002577)3.25472710
94positive regulation of type 2 immune response (GO:0002830)3.25313982
95positive regulation of B cell differentiation (GO:0045579)3.23994433
96low-density lipoprotein particle remodeling (GO:0034374)3.22539824
97regulation of mast cell activation (GO:0033003)3.22347160
98cholesterol efflux (GO:0033344)3.22044798
99plasma lipoprotein particle clearance (GO:0034381)3.21992494
100positive regulation of antigen processing and presentation (GO:0002579)3.20231660
101T-helper 1 type immune response (GO:0042088)3.20218728
102production of molecular mediator involved in inflammatory response (GO:0002532)3.19763750
103positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.19586280
104cellular modified amino acid catabolic process (GO:0042219)3.17716165
105negative regulation of cytokine production involved in immune response (GO:0002719)3.16509915
106neutrophil mediated immunity (GO:0002446)3.16096105
107response to protozoan (GO:0001562)3.15658751
108leukocyte migration involved in inflammatory response (GO:0002523)3.13156399
109regulation of T-helper 2 cell differentiation (GO:0045628)3.12754298
110regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.12147953
111positive regulation of interferon-alpha production (GO:0032727)3.11117840
112regulation of T cell tolerance induction (GO:0002664)3.11090283
113homocysteine metabolic process (GO:0050667)3.10890514
114regulation of gamma-delta T cell differentiation (GO:0045586)3.10116933
115regulation of cholesterol homeostasis (GO:2000188)3.09034848
116leukocyte aggregation (GO:0070486)3.07587200
117regulation of interferon-alpha production (GO:0032647)3.06514274
118regulation of tolerance induction (GO:0002643)3.05918592
119bile acid and bile salt transport (GO:0015721)3.03503521
120positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03071585
121positive regulation of mast cell degranulation (GO:0043306)3.02359687
122positive regulation of mast cell activation involved in immune response (GO:0033008)3.02359687
123regulation of protein activation cascade (GO:2000257)3.02099010
124regulation of B cell differentiation (GO:0045577)3.01208398
125disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.01180364
126killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.01180364
127plasma lipoprotein particle organization (GO:0071827)3.00433467
128NIK/NF-kappaB signaling (GO:0038061)2.98001348
129protein-lipid complex assembly (GO:0065005)2.97394788
130bile acid metabolic process (GO:0008206)2.96502913
131amino-acid betaine metabolic process (GO:0006577)2.95514720
132negative regulation of fibrinolysis (GO:0051918)2.94113047
133positive regulation of cellular amide metabolic process (GO:0034250)2.93683311
134regulation of cholesterol transport (GO:0032374)2.93496014
135regulation of sterol transport (GO:0032371)2.93496014
136cholesterol homeostasis (GO:0042632)2.92176360
137serine family amino acid catabolic process (GO:0009071)2.89789172
138drug catabolic process (GO:0042737)2.89715877
139sterol homeostasis (GO:0055092)2.88935276
140intestinal cholesterol absorption (GO:0030299)2.88847371
141response to interleukin-15 (GO:0070672)2.88255337
142aromatic amino acid family metabolic process (GO:0009072)2.87339066
143indolalkylamine metabolic process (GO:0006586)2.87334386
144lysine catabolic process (GO:0006554)2.86979797
145lysine metabolic process (GO:0006553)2.86979797
146positive regulation of gamma-delta T cell activation (GO:0046645)2.86264875
147positive thymic T cell selection (GO:0045059)2.86066359
148positive regulation of lipid catabolic process (GO:0050996)2.85352823
149acute-phase response (GO:0006953)2.84919002
150protein-lipid complex subunit organization (GO:0071825)2.84855397
151regulation of fibrinolysis (GO:0051917)2.84054565
152amine catabolic process (GO:0009310)2.82733406
153cellular biogenic amine catabolic process (GO:0042402)2.82733406
154regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.82614433
155regulation of type 2 immune response (GO:0002828)2.82451310
156negative regulation of interleukin-6 production (GO:0032715)2.81557723
157regulation of complement activation (GO:0030449)2.81496714
158regulation of regulated secretory pathway (GO:1903305)2.81021045
159positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.80874267
160myeloid leukocyte activation (GO:0002274)2.79492217
161leukocyte degranulation (GO:0043299)2.79442924
162myeloid leukocyte mediated immunity (GO:0002444)2.79440968
163positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.79248586
164killing of cells of other organism (GO:0031640)2.78595760
165disruption of cells of other organism (GO:0044364)2.78595760
166lymphocyte chemotaxis (GO:0048247)2.78470227
167negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.77067850
168dicarboxylic acid biosynthetic process (GO:0043650)2.76639332
169flavonoid metabolic process (GO:0009812)2.76472216
170acylglycerol homeostasis (GO:0055090)2.75656980
171triglyceride homeostasis (GO:0070328)2.75656980
172cellular response to interferon-gamma (GO:0071346)2.75479250
173valine metabolic process (GO:0006573)2.75362939
174negative regulation of cell killing (GO:0031342)2.74299253
175negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74299253
176T cell migration (GO:0072678)2.70803478
177cellular glucuronidation (GO:0052695)2.70210348
178aldehyde catabolic process (GO:0046185)2.69189308
179positive regulation of triglyceride lipase activity (GO:0061365)2.69164322
180positive regulation of lipoprotein lipase activity (GO:0051006)2.69164322
181glutamate metabolic process (GO:0006536)2.67874682
182hydrogen peroxide biosynthetic process (GO:0050665)2.67452254
183alpha-amino acid catabolic process (GO:1901606)2.65769365
184ethanol oxidation (GO:0006069)2.65639283
185benzene-containing compound metabolic process (GO:0042537)2.64492390
186very-low-density lipoprotein particle assembly (GO:0034379)2.62779660
187lipoprotein metabolic process (GO:0042157)2.61490730
188drug transmembrane transport (GO:0006855)2.61276649
189cellular ketone body metabolic process (GO:0046950)2.60217245
190positive regulation of triglyceride metabolic process (GO:0090208)2.59723254
191urate metabolic process (GO:0046415)2.58657535
192positive regulation of fatty acid biosynthetic process (GO:0045723)2.57630422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.47348375
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.74921825
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.37163986
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.96841753
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.82900330
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.64399583
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.39103139
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.34422112
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.19745596
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.12426002
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.72634507
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71691097
13MYC_22102868_ChIP-Seq_BL_Human2.65589646
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.49829220
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.46721238
16* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31801841
17* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.31425162
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.27319632
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.25502204
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.18416677
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16515975
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09367308
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98389201
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98334790
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95477047
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.94326547
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89484201
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88567120
29RUNX_20019798_ChIP-Seq_JUKART_Human1.75064300
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72784111
31* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69171571
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63581594
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63078348
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.61155544
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54945156
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53028822
37MAF_26560356_Chip-Seq_TH1_Human1.51846022
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50104318
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44921477
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43756194
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40871902
42* ELK3_25401928_ChIP-Seq_HUVEC_Human1.38858561
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37958404
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37672807
45NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30782280
46* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30093891
47* LXR_22292898_ChIP-Seq_THP-1_Human1.27884152
48* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27707637
49MYB_26560356_Chip-Seq_TH2_Human1.26215172
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24995709
51* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24162549
52MYB_26560356_Chip-Seq_TH1_Human1.23731297
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23427138
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22542002
55* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20700140
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20691791
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.19723182
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18833355
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.17771205
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16339241
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.14857341
62* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14597336
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.12648159
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11183221
65SCL_19346495_ChIP-Seq_HPC-7_Human1.11053703
66EGR1_19032775_ChIP-ChIP_M12_Human1.10278171
67VDR_21846776_ChIP-Seq_THP-1_Human1.10069176
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.09911103
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.09382067
70VDR_24763502_ChIP-Seq_THP-1_Human1.09369934
71UTX_26944678_Chip-Seq_JUKART_Human1.08838695
72VDR_24787735_ChIP-Seq_THP-1_Human1.07822487
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.07647770
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07198533
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06865978
76TCF7_22412390_ChIP-Seq_EML_Mouse1.06239633
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04186345
78GATA1_22025678_ChIP-Seq_K562_Human1.04132955
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04082145
80GATA3_27048872_Chip-Seq_THYMUS_Human1.03667561
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03181888
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.03154300
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02829152
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.02388866
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02372171
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02191985
87GATA4_25053715_ChIP-Seq_YYC3_Human1.02071118
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01263982
89SPI1_23127762_ChIP-Seq_K562_Human1.00931596
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99825038
91GATA2_19941826_ChIP-Seq_K562_Human0.97520391
92SPI1_23547873_ChIP-Seq_NB4_Human0.94802178
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93472552
94RACK7_27058665_Chip-Seq_MCF-7_Human0.92268101
95NCOR1_26117541_ChIP-Seq_K562_Human0.91856525
96* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89680277
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89424326
98RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89268973
99* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89152333
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89102163
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.89025949
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88925485
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88886736
104* PU_27001747_Chip-Seq_BMDM_Mouse0.88102181
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87843223
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87101464
107GATA1_19941826_ChIP-Seq_K562_Human0.86549747
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86198910
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85823733
110BCOR_27268052_Chip-Seq_Bcells_Human0.85431273
111GATA6_25053715_ChIP-Seq_YYC3_Human0.85102008
112BCL6_27268052_Chip-Seq_Bcells_Human0.85053951
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.84849401
114SPI1_20517297_ChIP-Seq_HL60_Human0.84702377
115* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84432200
116GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83920270
117TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83733155
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83665223
119GATA3_26560356_Chip-Seq_TH2_Human0.83079140
120HNF4A_19822575_ChIP-Seq_HepG2_Human0.83053057
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82740565
122* CLOCK_20551151_ChIP-Seq_293T_Human0.82154129
123* MAF_26560356_Chip-Seq_TH2_Human0.80656617
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78615296
125KDM2B_26808549_Chip-Seq_DND41_Human0.77580470
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.77482682
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76499113
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76360309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.35895603
2MP0002139_abnormal_hepatobiliary_system4.90882193
3MP0005085_abnormal_gallbladder_physiolo3.63303789
4MP0005365_abnormal_bile_salt3.57982423
5MP0008875_abnormal_xenobiotic_pharmacok3.18181318
6MP0009840_abnormal_foam_cell3.04135601
7MP0003436_decreased_susceptibility_to2.75723962
8MP0002138_abnormal_hepatobiliary_system2.56437230
9MP0003252_abnormal_bile_duct2.55654853
10MP0002254_reproductive_system_inflammat2.49468285
11MP0010329_abnormal_lipoprotein_level2.42788657
12MP0009785_altered_susceptibility_to2.41074902
13* MP0001835_abnormal_antigen_presentation2.36434023
14MP0003191_abnormal_cellular_cholesterol2.26757580
15MP0001666_abnormal_nutrient_absorption2.11010183
16MP0000685_abnormal_immune_system2.07025789
17MP0006082_CNS_inflammation2.06299688
18MP0005332_abnormal_amino_acid2.04729012
19MP0005025_abnormal_response_to2.02414021
20MP0002419_abnormal_innate_immunity1.95311368
21MP0005083_abnormal_biliary_tract1.93544694
22MP0009764_decreased_sensitivity_to1.92243243
23MP0001790_abnormal_immune_system1.90139610
24MP0005387_immune_system_phenotype1.90139610
25MP0003303_peritoneal_inflammation1.89572754
26MP0005671_abnormal_response_to1.86897694
27MP0009278_abnormal_bone_marrow1.81685048
28MP0005000_abnormal_immune_tolerance1.79602050
29MP0004019_abnormal_vitamin_homeostasis1.75486627
30MP0008260_abnormal_autophagy1.75059670
31MP0003724_increased_susceptibility_to1.74945553
32MP0001800_abnormal_humoral_immune1.73937359
33MP0003806_abnormal_nucleotide_metabolis1.72727136
34MP0004947_skin_inflammation1.72631021
35MP0000609_abnormal_liver_physiology1.71051920
36MP0000604_amyloidosis1.64977423
37* MP0002148_abnormal_hypersensitivity_rea1.63979990
38MP0005058_abnormal_lysosome_morphology1.63733616
39MP0005464_abnormal_platelet_physiology1.63434236
40MP0008469_abnormal_protein_level1.56112987
41MP0003300_gastrointestinal_ulcer1.55351653
42* MP0002723_abnormal_immune_serum1.54400946
43* MP0002452_abnormal_antigen_presenting1.52685704
44MP0005310_abnormal_salivary_gland1.50320747
45MP0010155_abnormal_intestine_physiology1.49184987
46MP0001845_abnormal_inflammatory_respons1.48723994
47* MP0001819_abnormal_immune_cell1.42618069
48MP0002118_abnormal_lipid_homeostasis1.41715241
49MP0005319_abnormal_enzyme/_coenzyme1.41110479
50MP0003195_calcinosis1.40496941
51* MP0002420_abnormal_adaptive_immunity1.40302669
52MP0000465_gastrointestinal_hemorrhage1.38002412
53MP0003828_pulmonary_edema1.37629872
54MP0001853_heart_inflammation1.36920527
55MP0009643_abnormal_urine_homeostasis1.36888750
56MP0005451_abnormal_body_composition1.35666806
57MP0010234_abnormal_vibrissa_follicle1.32572122
58MP0003075_altered_response_to1.31458695
59MP0001873_stomach_inflammation1.31013628
60MP0001545_abnormal_hematopoietic_system1.30940729
61MP0005397_hematopoietic_system_phenotyp1.30940729
62MP0002998_abnormal_bone_remodeling1.30927123
63MP0005584_abnormal_enzyme/coenzyme_acti1.30781930
64MP0002166_altered_tumor_susceptibility1.29216537
65MP0002405_respiratory_system_inflammati1.25339759
66MP0002396_abnormal_hematopoietic_system1.25230545
67MP0003183_abnormal_peptide_metabolism1.22090351
68MP0004510_myositis1.21901622
69MP0002006_tumorigenesis1.18801478
70MP0001533_abnormal_skeleton_physiology1.16762332
71MP0000703_abnormal_thymus_morphology1.15859814
72MP0009763_increased_sensitivity_to1.10419313
73MP0005166_decreased_susceptibility_to1.09767111
74MP0004883_abnormal_blood_vessel1.04480966
75MP0008004_abnormal_stomach_pH1.04004196
76MP0003866_abnormal_defecation1.03394678
77MP0004381_abnormal_hair_follicle1.03320162
78MP0001851_eye_inflammation1.02607370
79* MP0000716_abnormal_immune_system1.02555671
80MP0002277_abnormal_respiratory_mucosa1.01364677
81MP0003705_abnormal_hypodermis_morpholog1.01154653
82MP0005167_abnormal_blood-brain_barrier1.00274217
83MP0003186_abnormal_redox_activity0.99281602
84MP0002136_abnormal_kidney_physiology0.99036254
85MP0003329_amyloid_beta_deposits0.98937293
86MP0003690_abnormal_glial_cell0.97258453
87MP0005636_abnormal_mineral_homeostasis0.96336473
88MP0003763_abnormal_thymus_physiology0.95252557
89MP0009765_abnormal_xenobiotic_induced0.94202933
90MP0003172_abnormal_lysosome_physiology0.93697579
91MP0000858_altered_metastatic_potential0.90145421
92MP0004808_abnormal_hematopoietic_stem0.88039127
93* MP0002398_abnormal_bone_marrow0.86947956
94MP0002933_joint_inflammation0.84566601
95MP0000598_abnormal_liver_morphology0.82972671
96MP0001764_abnormal_homeostasis0.82772360
97MP0003453_abnormal_keratinocyte_physiol0.82730545
98MP0005164_abnormal_response_to0.81427315
99MP0002132_abnormal_respiratory_system0.81097272
100MP0000689_abnormal_spleen_morphology0.80962508
101MP0009642_abnormal_blood_homeostasis0.79380971
102* MP0002429_abnormal_blood_cell0.78440215
103MP0002722_abnormal_immune_system0.77886545
104MP0001765_abnormal_ion_homeostasis0.77201410
105MP0003656_abnormal_erythrocyte_physiolo0.76782083
106MP0004264_abnormal_extraembryonic_tissu0.75995592
107MP0003448_altered_tumor_morphology0.75853092
108MP0000343_altered_response_to0.75047510
109MP0004782_abnormal_surfactant_physiolog0.73934348
110MP0005390_skeleton_phenotype0.73508403
111MP0008874_decreased_physiological_sensi0.72582230
112MP0001663_abnormal_digestive_system0.70752228
113MP0003045_fibrosis0.69754509
114MP0003868_abnormal_feces_composition0.69653608
115MP0009333_abnormal_splenocyte_physiolog0.68905370
116MP0003011_delayed_dark_adaptation0.68393522
117MP0002796_impaired_skin_barrier0.68375005
118MP0000490_abnormal_crypts_of0.67477531
119MP0005647_abnormal_sex_gland0.66984696
120MP0001756_abnormal_urination0.66966066
121MP0005535_abnormal_body_temperature0.66840414
122MP0003795_abnormal_bone_structure0.64732543
123MP0005076_abnormal_cell_differentiation0.64165870
124MP0000920_abnormal_myelination0.63268969
125MP0003221_abnormal_cardiomyocyte_apopto0.60582258
126MP0003091_abnormal_cell_migration0.60453209
127MP0002332_abnormal_exercise_endurance0.59980856
128MP0000249_abnormal_blood_vessel0.59269870
129MP0000015_abnormal_ear_pigmentation0.56387828
130MP0000371_diluted_coat_color0.53504039
131MP0005075_abnormal_melanosome_morpholog0.53445375
132MP0002693_abnormal_pancreas_physiology0.53186321
133MP0005381_digestive/alimentary_phenotyp0.51678633
134MP0002019_abnormal_tumor_incidence0.45622123
135MP0002009_preneoplasia0.45317563

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)4.74524376
2Eczematoid dermatitis (HP:0000976)4.64751892
3Retrobulbar optic neuritis (HP:0100654)4.63930315
4Optic neuritis (HP:0100653)4.63930315
5Xanthomatosis (HP:0000991)4.34206128
6Deep venous thrombosis (HP:0002625)4.32515736
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.10948237
8Meningitis (HP:0001287)4.05417062
9Intrahepatic cholestasis (HP:0001406)4.01028397
10Joint hemorrhage (HP:0005261)3.99516664
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90540877
12Prolonged partial thromboplastin time (HP:0003645)3.88619676
13Recurrent bacterial skin infections (HP:0005406)3.78797040
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.78571904
15Recurrent abscess formation (HP:0002722)3.77400307
16Abnormality of glycolipid metabolism (HP:0010969)3.71445096
17Abnormality of liposaccharide metabolism (HP:0010968)3.71445096
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.71445096
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.64390146
20Hypobetalipoproteinemia (HP:0003563)3.48308574
21Complement deficiency (HP:0004431)3.45571465
22Increased cerebral lipofuscin (HP:0011813)3.43006186
23Hyperlipoproteinemia (HP:0010980)3.42154368
24Keratoconjunctivitis sicca (HP:0001097)3.40520350
25Systemic lupus erythematosus (HP:0002725)3.38302148
26Encephalitis (HP:0002383)3.35111400
27Abnormality of the common coagulation pathway (HP:0010990)3.32514089
28Cellulitis (HP:0100658)3.23392978
29Autoimmune thrombocytopenia (HP:0001973)3.15605115
30Keratoconjunctivitis (HP:0001096)3.11122849
31Pulmonary infiltrates (HP:0002113)3.07956116
32Myocardial infarction (HP:0001658)3.02464089
33Abnormality of sulfur amino acid metabolism (HP:0004339)2.98392832
34Hemoptysis (HP:0002105)2.97787028
35Abnormality of macrophages (HP:0004311)2.93761121
36Gingival bleeding (HP:0000225)2.93630288
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.91558520
38Loss of speech (HP:0002371)2.91551362
39Gingivitis (HP:0000230)2.89786886
40Elevated erythrocyte sedimentation rate (HP:0003565)2.87011225
41Hyperglycinuria (HP:0003108)2.86464561
42Recurrent skin infections (HP:0001581)2.85822842
43Chest pain (HP:0100749)2.84807891
44Recurrent fungal infections (HP:0002841)2.84603677
45Gastrointestinal stroma tumor (HP:0100723)2.83860479
46Inflammation of the large intestine (HP:0002037)2.81241238
47Vacuolated lymphocytes (HP:0001922)2.80090533
48Amyloidosis (HP:0011034)2.78106735
49Abnormality of complement system (HP:0005339)2.77842086
50Dysostosis multiplex (HP:0000943)2.77613447
51Epidermoid cyst (HP:0200040)2.76218590
52Gastrointestinal inflammation (HP:0004386)2.74983905
53Colitis (HP:0002583)2.73067183
54Hyperammonemia (HP:0001987)2.72767701
55Fat malabsorption (HP:0002630)2.68090457
56Petechiae (HP:0000967)2.63732790
57Hypolipoproteinemia (HP:0010981)2.62768771
58Hypercholesterolemia (HP:0003124)2.61264904
59Pustule (HP:0200039)2.60327147
60Prolonged bleeding time (HP:0003010)2.59827818
61Mediastinal lymphadenopathy (HP:0100721)2.59311732
62Conjugated hyperbilirubinemia (HP:0002908)2.55871543
63Premature loss of primary teeth (HP:0006323)2.55684678
64Gastrointestinal infarctions (HP:0005244)2.55179673
65Increased IgM level (HP:0003496)2.54981202
66Osteomyelitis (HP:0002754)2.53104347
67Periodontitis (HP:0000704)2.51940833
68Lymphopenia (HP:0001888)2.51158397
69Agammaglobulinemia (HP:0004432)2.50807205
70Glomerulonephritis (HP:0000099)2.50667906
71Arterial thrombosis (HP:0004420)2.50573839
72Abnormality of purine metabolism (HP:0004352)2.50556450
73Myositis (HP:0100614)2.48427387
74Ketosis (HP:0001946)2.47668165
75Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.46954567
76Abnormality of serine family amino acid metabolism (HP:0010894)2.46042789
77Abnormality of glycine metabolism (HP:0010895)2.46042789
78Leukocytosis (HP:0001974)2.44774158
79Recurrent sinusitis (HP:0011108)2.42995159
80Abnormality of proline metabolism (HP:0010907)2.42646665
81Hydroxyprolinuria (HP:0003080)2.42646665
82Nasal polyposis (HP:0100582)2.42585227
83Gangrene (HP:0100758)2.42090042
84Disinhibition (HP:0000734)2.40013257
85Stomatitis (HP:0010280)2.37333949
86Abnormality of cells of the lymphoid lineage (HP:0012140)2.37224825
87Hypergammaglobulinemia (HP:0010702)2.37129503
88Abnormality of fatty-acid metabolism (HP:0004359)2.36557379
89Purpura (HP:0000979)2.35376285
90Hypoalphalipoproteinemia (HP:0003233)2.35165146
91IgM deficiency (HP:0002850)2.34417592
92Episodic fever (HP:0001954)2.33958841
93Esophageal varix (HP:0002040)2.33609482
94Urticaria (HP:0001025)2.33556231
95Abnormality of nucleobase metabolism (HP:0010932)2.32727482
96Joint swelling (HP:0001386)2.32615452
97Orchitis (HP:0100796)2.32139102
98Panhypogammaglobulinemia (HP:0003139)2.31286995
99Abnormality of the pleura (HP:0002103)2.31134094
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30898603
101Abnormality of T cells (HP:0002843)2.30729929
102Abnormality of aspartate family amino acid metabolism (HP:0010899)2.30662745
103Hypochromic anemia (HP:0001931)2.30091365
104Menorrhagia (HP:0000132)2.28077807
105Restrictive lung disease (HP:0002091)2.27935659
106Sepsis (HP:0100806)2.27352268
107Recurrent viral infections (HP:0004429)2.26812960
108Recurrent bronchitis (HP:0002837)2.22843159
109Abnormality of the intrinsic pathway (HP:0010989)2.22734432
110Hemorrhage of the eye (HP:0011885)2.22403297
111Increased serum ferritin (HP:0003281)2.18093500
112Vasculitis (HP:0002633)2.17840448
113Malnutrition (HP:0004395)2.17759610
114Abnormality of T cell physiology (HP:0011840)2.17545061
115Epistaxis (HP:0000421)2.17452525
116Recurrent pneumonia (HP:0006532)2.16823814
117Granulocytopenia (HP:0001913)2.13909167
118Abnormality of T cell number (HP:0011839)2.10754352
119Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.09712941
120Hepatosplenomegaly (HP:0001433)2.09605216
121Chronic mucocutaneous candidiasis (HP:0002728)2.09143856
122Recurrent cutaneous fungal infections (HP:0011370)2.09143856
123Generalized aminoaciduria (HP:0002909)2.07773849
124Hypoglycemic coma (HP:0001325)2.07745528
125Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06556553
126Abnormality of the nasal mucosa (HP:0000433)2.06102106
127Vascular calcification (HP:0004934)2.05703772
128Hypochromic microcytic anemia (HP:0004840)2.04707596
129Pulmonary embolism (HP:0002204)2.04478689
130Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04306310
131Abnormality of polysaccharide metabolism (HP:0011012)2.04306310
132Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04306310
133Polyneuropathy (HP:0001271)2.03005719
134Chronic otitis media (HP:0000389)2.02485522
135Hyperglycinemia (HP:0002154)2.02464928
136Skin ulcer (HP:0200042)2.02424601
137Obstructive lung disease (HP:0006536)2.00082322
138Chronic obstructive pulmonary disease (HP:0006510)2.00082322
139Thrombophlebitis (HP:0004418)2.00011335
140Nephritis (HP:0000123)1.99888979
141Hepatocellular carcinoma (HP:0001402)1.99739846
142Hyperbilirubinemia (HP:0002904)1.99562184
143Increased IgE level (HP:0003212)1.99044276
144Pancreatitis (HP:0001733)1.98826727
145T lymphocytopenia (HP:0005403)1.97494059
146Abnormality of pyrimidine metabolism (HP:0004353)1.97069545
147Autoimmune hemolytic anemia (HP:0001890)1.96399822
148Gout (HP:0001997)1.96193809
149Neuronal loss in central nervous system (HP:0002529)1.95455348
150Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95014333
151Mutism (HP:0002300)1.93546290
152Recurrent lower respiratory tract infections (HP:0002783)1.93018873
153Vertigo (HP:0002321)1.92493005
154Steatorrhea (HP:0002570)1.91864675
155Anorexia (HP:0002039)1.91534524
156Sensorimotor neuropathy (HP:0007141)1.91025090
157Thick nail (HP:0001805)1.90992299
158Axonal loss (HP:0003447)1.90005450
159Spontaneous abortion (HP:0005268)1.89857576
160Ketoacidosis (HP:0001993)1.89708389
161Spontaneous hematomas (HP:0007420)1.89530818
162Interstitial pulmonary disease (HP:0006530)1.87186931
163Entropion (HP:0000621)1.86475529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.74790293
2ERN13.69748376
3MAP3K143.16992143
4TYK22.98461281
5MAP4K12.85655908
6PRPF4B2.79510498
7GRK62.69500584
8FGFR42.68460451
9RIPK42.62763520
10EPHB12.39177221
11TBK12.34079326
12IRAK42.25304071
13JAK32.18218626
14IKBKE2.10771324
15JAK12.04792027
16BLK2.00556276
17IRAK31.96426171
18TXK1.95933654
19MAP3K131.92232459
20SIK11.88591772
21CSK1.85925431
22MST1R1.81044379
23STK101.59873207
24IRAK21.55287055
25MST41.48816897
26ZAP701.48335913
27IKBKB1.47506586
28ITK1.43105763
29JAK21.41182966
30TRIB31.37544252
31TAOK11.36824357
32INSRR1.34394050
33BCKDK1.32016643
34SIK31.28438955
35PTK61.26840479
36TAOK21.25695996
37FGFR31.24800049
38PKN21.20054591
39CSF1R1.18527100
40MARK21.15784291
41BTK1.13555847
42MAP3K101.09786336
43GRK71.04430445
44SYK1.02500059
45FES1.00825150
46BMPR20.99748302
47HCK0.98662615
48LCK0.95938302
49PRKD20.90419675
50CHUK0.89877703
51PRKCQ0.89590440
52TGFBR20.88454108
53YES10.86355360
54CDC42BPA0.85284814
55FGR0.84308079
56SMG10.83881626
57MAP3K70.82528407
58KSR20.82065607
59RIPK10.81061940
60FRK0.80960955
61LRRK20.80183259
62PRKG20.77450495
63MAP2K20.76297564
64BMX0.72499173
65KIT0.71937461
66MAP3K20.70612183
67PDK10.70400727
68MAP2K60.70281299
69LYN0.68074502
70PTK20.67863653
71MAPK110.66947284
72CDK190.66917865
73PRKAA20.63179496
74HIPK20.62673568
75FLT30.62294878
76PIK3CG0.62248743
77PDPK10.61937608
78SIK20.61852670
79TEC0.60443422
80MAP3K120.60065332
81KDR0.59651678
82TNK20.58507420
83MAPK70.57841647
84TESK20.56864382
85MAP2K30.56583645
86CLK10.54922608
87MAP3K60.53864577
88PRKCH0.53466706
89CAMK1D0.51026314
90MAP3K50.50187224
91MAPK40.50141246
92PRKCD0.49985796
93MARK30.48491527
94RPS6KC10.47244228
95RPS6KL10.47244228
96MAP3K10.47193464
97CDK120.46991423
98IRAK10.45762125
99LMTK20.42831532
100ABL20.42738546
101DAPK20.42316751
102FYN0.41343662
103PIM10.40604966
104MAPK120.39093679
105MAP3K110.37742481
106RPS6KA60.37717863
107MOS0.37523974
108MAP3K30.37330490
109EGFR0.37103212
110ARAF0.36129470
111MAP2K40.35560160
112EPHA30.35544863
113TESK10.34781229
114SGK20.34586914
115ABL10.34549919
116MAP3K80.34234566
117PRKCZ0.33795199
118DYRK1B0.33691789
119GRK10.33105764
120CAMKK10.32790137
121ACVR1B0.32757322
122MATK0.32707572
123RAF10.32669709
124NME20.32233263
125SGK30.31362586
126PRKACG0.30960569
127RPS6KA20.30577261
128NLK0.30234110

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.19622094
2Nitrogen metabolism_Homo sapiens_hsa009103.02374837
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95054007
4Staphylococcus aureus infection_Homo sapiens_hsa051502.80996276
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75183395
6Autoimmune thyroid disease_Homo sapiens_hsa053202.60640379
7Arginine biosynthesis_Homo sapiens_hsa002202.39721291
8Complement and coagulation cascades_Homo sapiens_hsa046102.30709671
9Asthma_Homo sapiens_hsa053102.25361840
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24235931
11Tryptophan metabolism_Homo sapiens_hsa003802.22934572
12Fatty acid degradation_Homo sapiens_hsa000711.96849593
13Antigen processing and presentation_Homo sapiens_hsa046121.86933081
14Rheumatoid arthritis_Homo sapiens_hsa053231.73910897
15PPAR signaling pathway_Homo sapiens_hsa033201.72549546
16Caffeine metabolism_Homo sapiens_hsa002321.72499423
17Histidine metabolism_Homo sapiens_hsa003401.71206180
18Viral myocarditis_Homo sapiens_hsa054161.69672146
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69404559
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63135154
21Peroxisome_Homo sapiens_hsa041461.63093077
22Graft-versus-host disease_Homo sapiens_hsa053321.58795762
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56595313
24Bile secretion_Homo sapiens_hsa049761.51417126
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47980487
26Leishmaniasis_Homo sapiens_hsa051401.46101852
27Phagosome_Homo sapiens_hsa041451.45427438
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44712021
29Chemical carcinogenesis_Homo sapiens_hsa052041.40633642
30Herpes simplex infection_Homo sapiens_hsa051681.40280386
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39956298
32Sulfur metabolism_Homo sapiens_hsa009201.39880686
33Fatty acid metabolism_Homo sapiens_hsa012121.29215028
34ABC transporters_Homo sapiens_hsa020101.27976425
35beta-Alanine metabolism_Homo sapiens_hsa004101.27303883
36Butanoate metabolism_Homo sapiens_hsa006501.27267484
37Fat digestion and absorption_Homo sapiens_hsa049751.26735635
38Starch and sucrose metabolism_Homo sapiens_hsa005001.25302421
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.25062817
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17145894
41Salmonella infection_Homo sapiens_hsa051321.17084138
42Hepatitis B_Homo sapiens_hsa051611.14042255
43Allograft rejection_Homo sapiens_hsa053301.13508264
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13062274
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.12112726
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.09390930
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08464459
48Retinol metabolism_Homo sapiens_hsa008301.07494803
49Phenylalanine metabolism_Homo sapiens_hsa003601.07423026
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.05805146
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05489182
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03877444
53Osteoclast differentiation_Homo sapiens_hsa043801.02972838
54Vitamin digestion and absorption_Homo sapiens_hsa049770.99930707
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96665334
56Shigellosis_Homo sapiens_hsa051310.94747805
57Apoptosis_Homo sapiens_hsa042100.93557668
58Primary immunodeficiency_Homo sapiens_hsa053400.92185290
59Propanoate metabolism_Homo sapiens_hsa006400.91681163
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90987760
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90721712
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89581513
63Non-small cell lung cancer_Homo sapiens_hsa052230.89449606
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88663223
65Steroid biosynthesis_Homo sapiens_hsa001000.87995019
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.86938530
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85713179
68VEGF signaling pathway_Homo sapiens_hsa043700.85133081
69Platelet activation_Homo sapiens_hsa046110.83687291
70Epstein-Barr virus infection_Homo sapiens_hsa051690.82465514
71Pertussis_Homo sapiens_hsa051330.82147349
72Folate biosynthesis_Homo sapiens_hsa007900.81099159
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79739459
74Selenocompound metabolism_Homo sapiens_hsa004500.79330383
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79131211
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78736118
77Prolactin signaling pathway_Homo sapiens_hsa049170.77744293
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77237953
79Pancreatic cancer_Homo sapiens_hsa052120.76514182
80Measles_Homo sapiens_hsa051620.76362238
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.76132625
82Legionellosis_Homo sapiens_hsa051340.75787047
83Sulfur relay system_Homo sapiens_hsa041220.75326729
84Glycerolipid metabolism_Homo sapiens_hsa005610.74407187
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74336845
86Chronic myeloid leukemia_Homo sapiens_hsa052200.73825564
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.72276631
88TNF signaling pathway_Homo sapiens_hsa046680.71615819
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.68962032
90Pentose phosphate pathway_Homo sapiens_hsa000300.68113682
91Fructose and mannose metabolism_Homo sapiens_hsa000510.67756244
92T cell receptor signaling pathway_Homo sapiens_hsa046600.67053652
93Toxoplasmosis_Homo sapiens_hsa051450.66593708
94African trypanosomiasis_Homo sapiens_hsa051430.66466349
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66139688
96Tuberculosis_Homo sapiens_hsa051520.65323644
97B cell receptor signaling pathway_Homo sapiens_hsa046620.64803171
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64669769
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.64661632
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64566864
101Tyrosine metabolism_Homo sapiens_hsa003500.63914994
102Fatty acid biosynthesis_Homo sapiens_hsa000610.62423104
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62106933
104Endocytosis_Homo sapiens_hsa041440.61262396
105Notch signaling pathway_Homo sapiens_hsa043300.60794938
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.60014088
107Malaria_Homo sapiens_hsa051440.59601024
108Renal cell carcinoma_Homo sapiens_hsa052110.59537551
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59169313
110Hepatitis C_Homo sapiens_hsa051600.59152275
111Influenza A_Homo sapiens_hsa051640.58734186
112Insulin resistance_Homo sapiens_hsa049310.58606317
113Collecting duct acid secretion_Homo sapiens_hsa049660.58305121
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57937226
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57549833
116Lysosome_Homo sapiens_hsa041420.56819015
117Carbon metabolism_Homo sapiens_hsa012000.56739438
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56253695
119Amoebiasis_Homo sapiens_hsa051460.55038400
120Viral carcinogenesis_Homo sapiens_hsa052030.55036709
121HTLV-I infection_Homo sapiens_hsa051660.54930002
122Mineral absorption_Homo sapiens_hsa049780.53885350
123GnRH signaling pathway_Homo sapiens_hsa049120.52875998
124Chemokine signaling pathway_Homo sapiens_hsa040620.51848005
125Other glycan degradation_Homo sapiens_hsa005110.51332621
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.51215721
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.50643841
128Pyruvate metabolism_Homo sapiens_hsa006200.48641190
129Bladder cancer_Homo sapiens_hsa052190.48207819
130Acute myeloid leukemia_Homo sapiens_hsa052210.48205996
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47873568
132Lysine degradation_Homo sapiens_hsa003100.47277575
133HIF-1 signaling pathway_Homo sapiens_hsa040660.46151862
134Type II diabetes mellitus_Homo sapiens_hsa049300.45297318
135Systemic lupus erythematosus_Homo sapiens_hsa053220.43460029
136Glutathione metabolism_Homo sapiens_hsa004800.42736147
137Biosynthesis of amino acids_Homo sapiens_hsa012300.42179186
138FoxO signaling pathway_Homo sapiens_hsa040680.41737387
139Prion diseases_Homo sapiens_hsa050200.40786431
140Arginine and proline metabolism_Homo sapiens_hsa003300.40516066
141Type I diabetes mellitus_Homo sapiens_hsa049400.40490347
142Hematopoietic cell lineage_Homo sapiens_hsa046400.40256370
143Fatty acid elongation_Homo sapiens_hsa000620.40069853
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39803178
145Endometrial cancer_Homo sapiens_hsa052130.39241086
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37345028
147MAPK signaling pathway_Homo sapiens_hsa040100.37174647
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37170249
149Choline metabolism in cancer_Homo sapiens_hsa052310.36849929
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36722475
151mTOR signaling pathway_Homo sapiens_hsa041500.35160484
152Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34161505
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33180023
154ErbB signaling pathway_Homo sapiens_hsa040120.30709419
155Estrogen signaling pathway_Homo sapiens_hsa049150.29969978
156Dorso-ventral axis formation_Homo sapiens_hsa043200.29737820
157Prostate cancer_Homo sapiens_hsa052150.26521212
158Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25054788
159Inositol phosphate metabolism_Homo sapiens_hsa005620.24125657

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