SEMA4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.69298304
2viral transcription (GO:0019083)5.44123200
3ribosomal small subunit biogenesis (GO:0042274)5.12816841
4translational termination (GO:0006415)5.07580481
5maturation of SSU-rRNA (GO:0030490)4.78777396
6activation of Rac GTPase activity (GO:0032863)4.36780688
7cell-substrate junction assembly (GO:0007044)4.23303101
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.22632235
9positive regulation of Cdc42 GTPase activity (GO:0043089)4.16702989
10translational elongation (GO:0006414)4.15028440
11regulation of histone H3-K27 methylation (GO:0061085)4.13404910
12protein targeting to ER (GO:0045047)4.08909823
13cotranslational protein targeting to membrane (GO:0006613)4.08037995
14desmosome organization (GO:0002934)4.07841596
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.98399024
16viral life cycle (GO:0019058)3.89597732
17interferon-gamma secretion (GO:0072643)3.86084317
18establishment of protein localization to endoplasmic reticulum (GO:0072599)3.85701914
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85160237
20cellular protein complex disassembly (GO:0043624)3.82047561
21protein localization to endoplasmic reticulum (GO:0070972)3.80986898
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.74244837
23hemidesmosome assembly (GO:0031581)3.70995012
24protein localization to endosome (GO:0036010)3.65310833
25definitive hemopoiesis (GO:0060216)3.54857369
26histone H4-K12 acetylation (GO:0043983)3.49323758
27protein complex disassembly (GO:0043241)3.48676079
28antigen processing and presentation of endogenous antigen (GO:0019883)3.46994557
29detection of bacterium (GO:0016045)3.40166009
30translational initiation (GO:0006413)3.38884255
31surfactant homeostasis (GO:0043129)3.33399007
32skin morphogenesis (GO:0043589)3.32874138
33detection of other organism (GO:0098543)3.27239178
34ribosomal large subunit biogenesis (GO:0042273)3.25477851
35regulation of histone H3-K9 methylation (GO:0051570)3.20011313
36semaphorin-plexin signaling pathway (GO:0071526)3.18803013
37epithelial cell-cell adhesion (GO:0090136)3.15996727
38macromolecular complex disassembly (GO:0032984)3.14392070
39apoptotic process involved in morphogenesis (GO:0060561)3.13667204
40positive regulation of gamma-delta T cell activation (GO:0046645)3.11681016
41epithelial cell differentiation involved in prostate gland development (GO:0060742)3.05316448
42dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.05064462
43positive regulation of extracellular matrix organization (GO:1903055)3.01022695
44regulation of posttranscriptional gene silencing (GO:0060147)2.99897988
45regulation of gene silencing by miRNA (GO:0060964)2.99897988
46regulation of gene silencing by RNA (GO:0060966)2.99897988
47regulation of superoxide anion generation (GO:0032928)2.99470885
48nuclear-transcribed mRNA catabolic process (GO:0000956)2.99292220
49regulation of chemokine secretion (GO:0090196)2.95083699
50phospholipid scrambling (GO:0017121)2.93255170
51mRNA catabolic process (GO:0006402)2.92088266
52signal complex assembly (GO:0007172)2.91169049
53cell adhesion mediated by integrin (GO:0033627)2.89056680
54negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.88924579
55macrophage activation involved in immune response (GO:0002281)2.88634942
56regulation of cholesterol homeostasis (GO:2000188)2.88085347
57regulation of water loss via skin (GO:0033561)2.88012455
58regulation of apoptotic process involved in morphogenesis (GO:1902337)2.87613638
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87042408
60Golgi transport vesicle coating (GO:0048200)2.86635349
61COPI coating of Golgi vesicle (GO:0048205)2.86635349
62negative regulation of stress fiber assembly (GO:0051497)2.85111896
63negative regulation of translation, ncRNA-mediated (GO:0040033)2.82437168
64regulation of translation, ncRNA-mediated (GO:0045974)2.82437168
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82437168
66peptidyl-tyrosine autophosphorylation (GO:0038083)2.81543744
67positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.81244153
68negative regulation of viral release from host cell (GO:1902187)2.80212606
69negative regulation of histone methylation (GO:0031061)2.79537851
70positive regulation of histone deacetylation (GO:0031065)2.79379384
71negative regulation of keratinocyte proliferation (GO:0010839)2.79225472
72establishment of skin barrier (GO:0061436)2.78808963
73response to peptidoglycan (GO:0032494)2.77799520
74atrioventricular valve morphogenesis (GO:0003181)2.77718252
75focal adhesion assembly (GO:0048041)2.76249128
76cell-substrate adherens junction assembly (GO:0007045)2.76249128
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.76218822
78trophectodermal cell differentiation (GO:0001829)2.75853948
79regulation of extracellular matrix organization (GO:1903053)2.75672383
80negative regulation of epidermis development (GO:0045683)2.73468973
81mesodermal cell differentiation (GO:0048333)2.72806723
82hypotonic response (GO:0006971)2.72782615
83RNA catabolic process (GO:0006401)2.72637941
84citrulline biosynthetic process (GO:0019240)2.72536978
85B cell receptor signaling pathway (GO:0050853)2.72307796
86regulation of endothelial cell chemotaxis (GO:2001026)2.71639322
87modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71024849
88positive regulation by organism of defense response of other organism involved in symbiotic interact2.71024849
89modulation by symbiont of host immune response (GO:0052553)2.71024849
90positive regulation by symbiont of host defense response (GO:0052509)2.71024849
91modulation by symbiont of host defense response (GO:0052031)2.71024849
92modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71024849
93regulation of nuclear cell cycle DNA replication (GO:0033262)2.68334121
94regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67500904
95water homeostasis (GO:0030104)2.66889710
96regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.66575773
97daunorubicin metabolic process (GO:0044597)2.65928703
98polyketide metabolic process (GO:0030638)2.65928703
99doxorubicin metabolic process (GO:0044598)2.65928703
100protein retention in ER lumen (GO:0006621)2.65772021
101response to laminar fluid shear stress (GO:0034616)2.65502430
102positive regulation of epidermal cell differentiation (GO:0045606)2.65444880
103keratinization (GO:0031424)2.62338048
104detection of external biotic stimulus (GO:0098581)2.60996107
105regulation of viral release from host cell (GO:1902186)2.60266507
106ribonucleoprotein complex biogenesis (GO:0022613)2.58592292
107negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.58124943
108glucose 6-phosphate metabolic process (GO:0051156)2.56995807
109regulation of T-helper 2 cell differentiation (GO:0045628)2.56896155
110regulation of metalloenzyme activity (GO:0048552)2.56659286
111mammary gland epithelial cell proliferation (GO:0033598)2.55888966
112mannose metabolic process (GO:0006013)2.55486594
113determination of adult lifespan (GO:0008340)2.55397397
114regulation of extracellular matrix disassembly (GO:0010715)2.54547382
115regulation of gene silencing (GO:0060968)2.53778521
116positive regulation of epidermis development (GO:0045684)2.53769628
117antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.53688624
118negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.53483175
119negative regulation of cell killing (GO:0031342)2.53483175
120regulation of interferon-beta biosynthetic process (GO:0045357)2.53019777
121amino sugar catabolic process (GO:0046348)2.51787150
122endothelial cell chemotaxis (GO:0035767)2.51689828
123adherens junction assembly (GO:0034333)2.50626555
124negative regulation of epidermal cell differentiation (GO:0045605)2.50438131
125regulation of glucose import in response to insulin stimulus (GO:2001273)2.49267750
126positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.48844732
127lateral sprouting from an epithelium (GO:0060601)2.48465705
128keratinocyte proliferation (GO:0043616)2.47762164
129positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.47019134
130embryonic process involved in female pregnancy (GO:0060136)2.46100499
131sympathetic nervous system development (GO:0048485)2.42868911
132protein targeting to membrane (GO:0006612)2.42653569
133germinal center formation (GO:0002467)2.41045770
134positive regulation of receptor recycling (GO:0001921)2.40435340
135regulation of histone methylation (GO:0031060)2.38767059
136planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38363675
137response to muramyl dipeptide (GO:0032495)2.38148979
138keratinocyte development (GO:0003334)2.38141827
139hepatocyte apoptotic process (GO:0097284)2.37470063
140one-carbon compound transport (GO:0019755)2.37198731
141NIK/NF-kappaB signaling (GO:0038061)2.36404282
142ear development (GO:0043583)2.36333428
143mature B cell differentiation involved in immune response (GO:0002313)2.35982953
144mature B cell differentiation (GO:0002335)2.35638811
145glucosamine-containing compound catabolic process (GO:1901072)2.35293361
146positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.34888275
147positive regulation of blood vessel endothelial cell migration (GO:0043536)2.34857692
148chemical homeostasis within a tissue (GO:0048875)2.34569845
149negative regulation of erythrocyte differentiation (GO:0045647)2.34156225
150regulation of helicase activity (GO:0051095)2.34003276
151production of molecular mediator involved in inflammatory response (GO:0002532)2.33578226
152histone H3-K4 methylation (GO:0051568)2.33483119
153negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.31937891
154response to host defenses (GO:0052200)2.30790836
155response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.30790836
156response to host (GO:0075136)2.30790836
157regulation of cell proliferation involved in kidney development (GO:1901722)2.30206039
158lung epithelium development (GO:0060428)2.29870265
159regulation of Cdc42 GTPase activity (GO:0043088)2.29650161
160bundle of His cell to Purkinje myocyte communication (GO:0086069)2.28900450
161negative regulation of myotube differentiation (GO:0010832)2.28653207
162dendritic cell chemotaxis (GO:0002407)2.27842385
163face development (GO:0060324)2.26170247
164regulation of gamma-delta T cell activation (GO:0046643)2.24784702
165antimicrobial humoral response (GO:0019730)2.23363862
166regulation of B cell differentiation (GO:0045577)2.21699470
167negative regulation of bone resorption (GO:0045779)2.21557285
168regulation of histone H3-K4 methylation (GO:0051569)2.21544861
169maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.21121909
170histone H4-K5 acetylation (GO:0043981)2.18543975
171histone H4-K8 acetylation (GO:0043982)2.18543975
172antibacterial humoral response (GO:0019731)2.17857146
173positive regulation of B cell differentiation (GO:0045579)2.17430229
174DNA deamination (GO:0045006)2.16439242
175multicellular organismal water homeostasis (GO:0050891)2.15641361
176dendritic cell migration (GO:0036336)2.15341132
177intestinal epithelial cell development (GO:0060576)2.14884111
178embryonic hemopoiesis (GO:0035162)2.14530875
179keratinocyte differentiation (GO:0030216)2.13370714
180lymphoid progenitor cell differentiation (GO:0002320)2.13330308
181positive regulation of keratinocyte differentiation (GO:0045618)2.13018421
182B cell differentiation (GO:0030183)2.12943115
183histone H3-K4 trimethylation (GO:0080182)2.11111893
184branching involved in mammary gland duct morphogenesis (GO:0060444)2.11110684
185translation (GO:0006412)2.10788458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.19241852
2E2F7_22180533_ChIP-Seq_HELA_Human4.36142030
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.75603853
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.75603853
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.75603853
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.11322827
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.57496049
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56331906
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.54462725
10MYC_22102868_ChIP-Seq_BL_Human2.51442570
11RACK7_27058665_Chip-Seq_MCF-7_Human2.46100160
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.44382572
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.41947531
14* LXR_22292898_ChIP-Seq_THP-1_Human2.41931547
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.41560055
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.37538188
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31712807
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31400036
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26267003
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.25226065
21SCL_19346495_ChIP-Seq_HPC-7_Human2.24902517
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.14655031
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.13370881
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12042569
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11672292
26* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.10494419
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08761914
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.05659595
29* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.04715422
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04236688
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99302270
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98948944
33* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.97912792
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94706671
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93736106
36VDR_21846776_ChIP-Seq_THP-1_Human1.92632423
37SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.90279965
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86612576
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.86137699
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.78563202
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.77746792
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76150745
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.76058678
44* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.75889761
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75612696
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75276509
47KDM2B_26808549_Chip-Seq_DND41_Human1.72819181
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72812989
49NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.71224991
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68094958
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.67468418
52* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66955279
53KDM2B_26808549_Chip-Seq_K562_Human1.64827185
54ATF3_27146783_Chip-Seq_COLON_Human1.64556617
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.64037538
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60223576
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.59890677
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.57841876
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.52575243
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51901502
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51592205
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51412202
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51405213
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49938970
65* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49578135
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.48876462
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47647746
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46876512
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45467969
70* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44475691
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38441668
72* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.34439976
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33684909
74SMC4_20622854_ChIP-Seq_HELA_Human1.33581199
75CLOCK_20551151_ChIP-Seq_293T_Human1.33226470
76* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32731887
77* FOXM1_23109430_ChIP-Seq_U2OS_Human1.31856403
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29615569
79RUNX_20019798_ChIP-Seq_JUKART_Human1.28407712
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27588158
81MYB_26560356_Chip-Seq_TH1_Human1.27091465
82MAF_26560356_Chip-Seq_TH1_Human1.26653799
83* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.26167937
84P68_20966046_ChIP-Seq_HELA_Human1.25943028
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25738038
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25158544
87* TCF7_22412390_ChIP-Seq_EML_Mouse1.24943983
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24847956
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24375695
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24351145
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24195285
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24023037
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23461107
94* SA1_27219007_Chip-Seq_ERYTHROID_Human1.23288317
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.23152935
96* TP63_22573176_ChIP-Seq_HFKS_Human1.22186469
97CREB1_26743006_Chip-Seq_LNCaP_Human1.22070188
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21914866
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19982194
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19413262
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19226539
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.19123061
103* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.19056371
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18955464
105UTX_26944678_Chip-Seq_JUKART_Human1.17412523
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16391327
107PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16369671
108* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16138490
109* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15635213
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.15512313
111MYB_26560356_Chip-Seq_TH2_Human1.15377978
112* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14984456
113* KLF5_25053715_ChIP-Seq_YYC3_Human1.14603731
114BCOR_27268052_Chip-Seq_Bcells_Human1.14545846
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14401358
116* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.13938925
117GATA6_25053715_ChIP-Seq_YYC3_Human1.13926901
118CIITA_25753668_ChIP-Seq_RAJI_Human1.13810714
119PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13743320
120* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13198124
121P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12970372
122* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12555023
123UBF1/2_26484160_Chip-Seq_HMECs_Human1.11998196
124* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11554353
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09895836
126RXR_22158963_ChIP-Seq_LIVER_Mouse1.09679681
127TET1_21451524_ChIP-Seq_MESCs_Mouse1.09374463
128GATA2_21666600_ChIP-Seq_HMVEC_Human1.09155054
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09075750
130* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.07841391
131SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07772573
132* SOX2_20726797_ChIP-Seq_SW620_Human1.06595515
133NCOR1_26117541_ChIP-Seq_K562_Human1.06560639
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.06326090
135ZNF263_19887448_ChIP-Seq_K562_Human1.05739542
136* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05443979
137CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05278086
138NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04935571
139SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04912752
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04912752
141NANOG_21062744_ChIP-ChIP_HESCs_Human1.04878175
142* SPI1_23127762_ChIP-Seq_K562_Human1.04728773
143* SPI1_23547873_ChIP-Seq_NB4_Human1.04694604
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04595869
145RUNX1_22412390_ChIP-Seq_EML_Mouse1.03077905
146* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02131173
147MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01192679
148* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01161592
149VDR_24763502_ChIP-Seq_THP-1_Human1.01142068
150SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00233922
151KAP1_27257070_Chip-Seq_ESCs_Mouse0.99740628
152TRIM28_21343339_ChIP-Seq_HEK293_Human0.99452258
153CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99396807
154DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98142935
155WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96961380
156* GATA1_19941827_ChIP-Seq_MEL_Mouse0.96800393
157SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96585221
158SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96483934
159TP53_22127205_ChIP-Seq_IMR90_Human0.96211461
160MAF_26560356_Chip-Seq_TH2_Human0.95883338
161FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95807680
162* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95124402
163TTF2_22483619_ChIP-Seq_HELA_Human0.94971851
164TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93383928
165* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93242423
166KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92412882
167* RUNX1_27514584_Chip-Seq_MCF-7_Human0.92054550
168* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91772168
169ELK1_22589737_ChIP-Seq_MCF10A_Human0.90015165
170TCF4_18268006_ChIP-ChIP_LS174T_Human0.88536114
171RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88504140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.80604354
2MP0003941_abnormal_skin_development3.49084662
3MP0000579_abnormal_nail_morphology3.42795037
4MP0003705_abnormal_hypodermis_morpholog3.07556373
5MP0002254_reproductive_system_inflammat2.71277334
6MP0004381_abnormal_hair_follicle2.64522608
7MP0003191_abnormal_cellular_cholesterol2.61529305
8MP0001849_ear_inflammation2.45925990
9MP0008260_abnormal_autophagy2.43245901
10MP0002796_impaired_skin_barrier2.42199890
11MP0006292_abnormal_olfactory_placode2.36948982
12MP0009379_abnormal_foot_pigmentation2.31813397
13MP0003436_decreased_susceptibility_to2.22667372
14MP0002009_preneoplasia2.20861153
15MP0005076_abnormal_cell_differentiation2.18172685
16MP0000566_synostosis2.17777285
17MP0005451_abnormal_body_composition2.13326481
18MP0000383_abnormal_hair_follicle2.02558566
19MP0008789_abnormal_olfactory_epithelium1.98051591
20MP0005023_abnormal_wound_healing1.94886453
21MP0003763_abnormal_thymus_physiology1.92448775
22MP0003453_abnormal_keratinocyte_physiol1.90637647
23MP0000858_altered_metastatic_potential1.90078644
24MP0005501_abnormal_skin_physiology1.85341937
25MP0005174_abnormal_tail_pigmentation1.85243599
26MP0001800_abnormal_humoral_immune1.82931411
27MP0009840_abnormal_foam_cell1.78377643
28MP0005394_taste/olfaction_phenotype1.77598281
29MP0005499_abnormal_olfactory_system1.77598281
30MP0002098_abnormal_vibrissa_morphology1.77332636
31MP0004858_abnormal_nervous_system1.74065567
32MP0002277_abnormal_respiratory_mucosa1.73984500
33MP0002132_abnormal_respiratory_system1.72554678
34MP0003786_premature_aging1.72304604
35MP0000490_abnormal_crypts_of1.71262850
36MP0003300_gastrointestinal_ulcer1.70671538
37MP0001835_abnormal_antigen_presentation1.68784383
38MP0005377_hearing/vestibular/ear_phenot1.67617406
39MP0003878_abnormal_ear_physiology1.67617406
40MP0005075_abnormal_melanosome_morpholog1.67008975
41MP0008057_abnormal_DNA_replication1.58871810
42MP0005409_darkened_coat_color1.58839240
43MP0001216_abnormal_epidermal_layer1.58221717
44MP0005387_immune_system_phenotype1.55216650
45MP0001790_abnormal_immune_system1.55216650
46MP0003303_peritoneal_inflammation1.54079355
47MP0010352_gastrointestinal_tract_polyps1.53889267
48MP0005058_abnormal_lysosome_morphology1.45510470
49MP0000465_gastrointestinal_hemorrhage1.41811401
50MP0002060_abnormal_skin_morphology1.40234021
51MP0003693_abnormal_embryo_hatching1.38822088
52MP0004782_abnormal_surfactant_physiolog1.38442768
53MP0003183_abnormal_peptide_metabolism1.38138675
54MP0002095_abnormal_skin_pigmentation1.37970131
55MP0002452_abnormal_antigen_presenting1.37630589
56MP0003091_abnormal_cell_migration1.37351243
57MP0000685_abnormal_immune_system1.36989889
58MP0000537_abnormal_urethra_morphology1.36581143
59MP0000762_abnormal_tongue_morphology1.35265840
60MP0003866_abnormal_defecation1.33577822
61MP0002396_abnormal_hematopoietic_system1.33148792
62MP0003724_increased_susceptibility_to1.31727938
63MP0010030_abnormal_orbit_morphology1.31165922
64MP0001986_abnormal_taste_sensitivity1.30350206
65MP0010678_abnormal_skin_adnexa1.28754523
66MP0008058_abnormal_DNA_repair1.28608862
67MP0002398_abnormal_bone_marrow1.27874999
68MP0002653_abnormal_ependyma_morphology1.27157686
69MP0002249_abnormal_larynx_morphology1.27110473
70MP0010234_abnormal_vibrissa_follicle1.25713325
71MP0003172_abnormal_lysosome_physiology1.25371333
72MP0010094_abnormal_chromosome_stability1.25166530
73MP0004185_abnormal_adipocyte_glucose1.23998795
74MP0010155_abnormal_intestine_physiology1.23872590
75MP0001853_heart_inflammation1.23152934
76MP0001873_stomach_inflammation1.22152492
77MP0005275_abnormal_skin_tensile1.21960724
78MP0002420_abnormal_adaptive_immunity1.19689918
79MP0003566_abnormal_cell_adhesion1.19661146
80MP0000689_abnormal_spleen_morphology1.18994460
81MP0001919_abnormal_reproductive_system1.18630382
82MP0004272_abnormal_basement_membrane1.18351326
83MP0002419_abnormal_innate_immunity1.17960921
84MP0001533_abnormal_skeleton_physiology1.16963682
85MP0000467_abnormal_esophagus_morphology1.16575389
86MP0002722_abnormal_immune_system1.16019854
87MP0009278_abnormal_bone_marrow1.15890642
88MP0001819_abnormal_immune_cell1.15245570
89MP0008995_early_reproductive_senescence1.15011112
90MP0004947_skin_inflammation1.12615003
91MP0005671_abnormal_response_to1.11900527
92MP0004808_abnormal_hematopoietic_stem1.11849007
93MP0005164_abnormal_response_to1.11594595
94MP0000049_abnormal_middle_ear1.11560042
95MP0008007_abnormal_cellular_replicative1.10524896
96MP0005083_abnormal_biliary_tract1.10212633
97MP0002877_abnormal_melanocyte_morpholog1.10084108
98MP0002723_abnormal_immune_serum1.08664268
99MP0000377_abnormal_hair_follicle1.08593144
100MP0004510_myositis1.08046838
101MP0005360_urolithiasis1.07867789
102MP0003045_fibrosis1.07043892
103MP0005000_abnormal_immune_tolerance1.06887829
104MP0000613_abnormal_salivary_gland1.06100356
105MP0003111_abnormal_nucleus_morphology1.05901979
106MP0000716_abnormal_immune_system1.03820162
107MP0010771_integument_phenotype1.02916897
108MP0009785_altered_susceptibility_to1.02789783
109MP0000678_abnormal_parathyroid_gland1.01668598
110MP0002405_respiratory_system_inflammati1.01065249
111MP0000703_abnormal_thymus_morphology0.99973894
112MP0001188_hyperpigmentation0.99737126
113MP0001851_eye_inflammation0.99299956
114MP0000647_abnormal_sebaceous_gland0.97116178
115MP0003077_abnormal_cell_cycle0.96303756
116MP0002998_abnormal_bone_remodeling0.95393881
117MP0003315_abnormal_perineum_morphology0.95089885
118MP0008004_abnormal_stomach_pH0.94181576
119MP0003075_altered_response_to0.92354018
120MP0002075_abnormal_coat/hair_pigmentati0.91171868
121MP0000015_abnormal_ear_pigmentation0.90014209
122MP0001186_pigmentation_phenotype0.89754403
123MP0002148_abnormal_hypersensitivity_rea0.89719761
124MP0004264_abnormal_extraembryonic_tissu0.89594353
125MP0002429_abnormal_blood_cell0.89438869
126MP0002089_abnormal_postnatal_growth/wei0.88534536
127MP0000477_abnormal_intestine_morphology0.88115431
128MP0009333_abnormal_splenocyte_physiolog0.87536147
129MP0000627_abnormal_mammary_gland0.87492885
130MP0005666_abnormal_adipose_tissue0.86233746
131MP0009931_abnormal_skin_appearance0.85376194
132MP0004957_abnormal_blastocyst_morpholog0.85123615
133MP0003329_amyloid_beta_deposits0.84990868
134MP0001348_abnormal_lacrimal_gland0.84703461
135MP0002166_altered_tumor_susceptibility0.84413962
136MP0000432_abnormal_head_morphology0.82449694
137MP0001545_abnormal_hematopoietic_system0.82115361
138MP0005397_hematopoietic_system_phenotyp0.82115361
139MP0002233_abnormal_nose_morphology0.81722861
140MP0005166_decreased_susceptibility_to0.81078354
141MP0005375_adipose_tissue_phenotype0.80921676
142MP0003938_abnormal_ear_development0.80249092
143MP0000372_irregular_coat_pigmentation0.80082058
144MP0000367_abnormal_coat/_hair0.77675259
145MP0002896_abnormal_bone_mineralization0.77289755
146MP0009053_abnormal_anal_canal0.77202629
147MP0005025_abnormal_response_to0.76716004
148MP0002138_abnormal_hepatobiliary_system0.76357484
149MP0005310_abnormal_salivary_gland0.73756240
150MP0005621_abnormal_cell_physiology0.72472404
151MP0000003_abnormal_adipose_tissue0.71695827
152MP0002933_joint_inflammation0.71581480
153MP0005390_skeleton_phenotype0.71008487
154MP0001845_abnormal_inflammatory_respons0.70724400
155MP0003828_pulmonary_edema0.69797346
156MP0003448_altered_tumor_morphology0.68199876
157MP0005464_abnormal_platelet_physiology0.66090291
158MP0001765_abnormal_ion_homeostasis0.65409777

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)4.47343409
2Thick nail (HP:0001805)4.41420147
3Abnormality of nail color (HP:0100643)4.18887420
4Right ventricular cardiomyopathy (HP:0011663)4.03227639
5Atrophic scars (HP:0001075)3.98841763
6Agammaglobulinemia (HP:0004432)3.96167403
7Alopecia of scalp (HP:0002293)3.94701802
8Onycholysis (HP:0001806)3.60709309
9Reticulocytopenia (HP:0001896)3.43481794
10Abnormal blistering of the skin (HP:0008066)3.21548133
11Abnormality of cells of the erythroid lineage (HP:0012130)3.20759072
12Abnormality of secondary sexual hair (HP:0009888)3.18770310
13Abnormality of the axillary hair (HP:0100134)3.18770310
14Broad face (HP:0000283)3.13372999
15Fragile nails (HP:0001808)3.12963950
16IgM deficiency (HP:0002850)3.09305842
17Eczematoid dermatitis (HP:0000976)2.96878613
18Abnormal number of erythroid precursors (HP:0012131)2.96479017
19Milia (HP:0001056)2.93947592
20Abnormal hair laboratory examination (HP:0003328)2.88060267
21Interstitial pulmonary disease (HP:0006530)2.83658407
22Ridged nail (HP:0001807)2.81082499
23Fragile skin (HP:0001030)2.79190282
24Malnutrition (HP:0004395)2.72963876
25Abnormal sex determination (HP:0012244)2.59620599
26Sex reversal (HP:0012245)2.59620599
27Hypoplasia of dental enamel (HP:0006297)2.58247368
28Amelogenesis imperfecta (HP:0000705)2.55749514
29Axonal loss (HP:0003447)2.52065470
3011 pairs of ribs (HP:0000878)2.47665547
31Cellulitis (HP:0100658)2.47308787
32Gastrointestinal stroma tumor (HP:0100723)2.46631972
33Sparse scalp hair (HP:0002209)2.46274274
34Pterygium (HP:0001059)2.45695558
35Distal lower limb amyotrophy (HP:0008944)2.45032286
36Ankyloglossia (HP:0010296)2.42663147
37Flat acetabular roof (HP:0003180)2.41723496
38Hypotrichosis (HP:0001006)2.41554799
39Plantar hyperkeratosis (HP:0007556)2.40643941
40Abnormality of the fingertips (HP:0001211)2.34649957
41Increased connective tissue (HP:0009025)2.33976215
42Focal segmental glomerulosclerosis (HP:0000097)2.30511210
43Distal lower limb muscle weakness (HP:0009053)2.29565983
44Abnormal hemoglobin (HP:0011902)2.29449061
45Abnormality of macrophages (HP:0004311)2.28781626
46Recurrent bacterial skin infections (HP:0005406)2.27488791
47Arterial tortuosity (HP:0005116)2.26369284
48Abnormality of B cell number (HP:0010975)2.26254520
49B lymphocytopenia (HP:0010976)2.26254520
50Pallor (HP:0000980)2.23129441
51Recurrent sinusitis (HP:0011108)2.22611120
52Panhypogammaglobulinemia (HP:0003139)2.22070949
53Selective tooth agenesis (HP:0001592)2.21627249
54Abnormality of the distal phalanges of the toes (HP:0010182)2.20966184
55Osteomalacia (HP:0002749)2.19790670
56Distal upper limb amyotrophy (HP:0007149)2.18381733
57Upper limb amyotrophy (HP:0009129)2.18381733
58Macrocytic anemia (HP:0001972)2.18151242
59Hemorrhage of the eye (HP:0011885)2.17547427
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17334603
61Advanced eruption of teeth (HP:0006288)2.16050861
62Aplasia cutis congenita (HP:0001057)2.14883340
63Partial duplication of thumb phalanx (HP:0009944)2.14744331
64Meningitis (HP:0001287)2.14026913
65Deep venous thrombosis (HP:0002625)2.13044936
66Colitis (HP:0002583)2.12570371
67Absent thumb (HP:0009777)2.11191324
68Neurofibrillary tangles (HP:0002185)2.10035146
69Obstructive sleep apnea (HP:0002870)2.09962598
70Increased IgE level (HP:0003212)2.09098779
71Oligodontia (HP:0000677)2.09071736
72Papilloma (HP:0012740)2.07233499
73Verrucae (HP:0200043)2.07233499
74Ectropion (HP:0000656)2.06869508
75Hyperacusis (HP:0010780)2.06725727
76Subacute progressive viral hepatitis (HP:0006572)2.06250299
77Clubbing of toes (HP:0100760)2.05696235
78Cervical subluxation (HP:0003308)2.05354591
79Thin bony cortex (HP:0002753)2.05017468
80Polygenic inheritance (HP:0010982)2.04739133
81Abnormality of oral frenula (HP:0000190)2.02726497
82Abnormal delayed hypersensitivity skin test (HP:0002963)2.02591713
83Asplenia (HP:0001746)2.02061565
84Chromsome breakage (HP:0040012)2.01860552
85Inflammation of the large intestine (HP:0002037)2.00113725
86Recurrent bronchitis (HP:0002837)1.97715462
87Natal tooth (HP:0000695)1.96682410
88Gingivitis (HP:0000230)1.96144939
89Aplasia/hypoplasia of the uterus (HP:0008684)1.94446001
90Thyroiditis (HP:0100646)1.94289664
91Ureteral stenosis (HP:0000071)1.93890458
92Rib fusion (HP:0000902)1.93738997
93Abnormality of the salivary glands (HP:0010286)1.92763189
94Skin ulcer (HP:0200042)1.92166485
95Premature loss of primary teeth (HP:0006323)1.91735404
96Short nail (HP:0001799)1.91478855
97Myositis (HP:0100614)1.91370198
98Glomerulosclerosis (HP:0000096)1.90944115
99Recurrent abscess formation (HP:0002722)1.90850610
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90182639
101Aplasia/Hypoplasia of the spleen (HP:0010451)1.89744262
102Easy fatigability (HP:0003388)1.89642841
103Abnormal vertebral ossification (HP:0100569)1.88651239
104Esophageal atresia (HP:0002032)1.88608978
105Cerebral inclusion bodies (HP:0100314)1.87649924
106Woolly hair (HP:0002224)1.86658031
107Abnormality of the nasal septum (HP:0000419)1.86446385
108Type I transferrin isoform profile (HP:0003642)1.86235698
109Gastrointestinal inflammation (HP:0004386)1.86151310
110Abnormality of the preputium (HP:0100587)1.84992165
111Sepsis (HP:0100806)1.84893903
112Orchitis (HP:0100796)1.84768440
113Blepharitis (HP:0000498)1.84659785
114Hypoplasia of the ulna (HP:0003022)1.84583371
115Palmar hyperkeratosis (HP:0010765)1.83484824
116Sparse eyelashes (HP:0000653)1.83178828
117Pili torti (HP:0003777)1.83070902
118Micronodular cirrhosis (HP:0001413)1.82828749
119Hypoplasia of the radius (HP:0002984)1.82588874
120IgA deficiency (HP:0002720)1.82275770
121Loss of speech (HP:0002371)1.81322981
122Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.81219330
123Difficulty climbing stairs (HP:0003551)1.80794587
124Cheilitis (HP:0100825)1.80032791
125Vascular tortuosity (HP:0004948)1.79613411
126Abnormality of the columella (HP:0009929)1.78347735
127Ureteral obstruction (HP:0006000)1.77580345
128Trismus (HP:0000211)1.77105177
129Concave nail (HP:0001598)1.76484619
130Median cleft lip (HP:0000161)1.75153353
131Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74982618
132Aplasia involving bones of the upper limbs (HP:0009823)1.74868007
133Aplasia of the phalanges of the hand (HP:0009802)1.74868007
134Aplasia involving bones of the extremities (HP:0009825)1.74868007
135Lymphopenia (HP:0001888)1.74287465
136Supernumerary spleens (HP:0009799)1.74049277
137Amyloidosis (HP:0011034)1.73941550
138Acanthosis nigricans (HP:0000956)1.73061280
139Prolonged bleeding time (HP:0003010)1.72893001
140Nasolacrimal duct obstruction (HP:0000579)1.72608111
141Cerebral aneurysm (HP:0004944)1.72324871
142Vertebral compression fractures (HP:0002953)1.72207336
143Erythema (HP:0010783)1.71635643
144Recurrent viral infections (HP:0004429)1.71180741
145Segmental peripheral demyelination/remyelination (HP:0003481)1.70831196
146Nail dystrophy (HP:0008404)1.69399012
147Aplasia/Hypoplasia of the ulna (HP:0006495)1.69304262
148Palmoplantar hyperkeratosis (HP:0000972)1.69233315
149Urticaria (HP:0001025)1.67751929
150Bronchomalacia (HP:0002780)1.67030354
151Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.67030136
152Dehydration (HP:0001944)1.66968316
153Lymphoma (HP:0002665)1.66768728
154Hyperparathyroidism (HP:0000843)1.66337051
155Bone pain (HP:0002653)1.66313752
156Anal stenosis (HP:0002025)1.65753699
157Nasal polyposis (HP:0100582)1.65273011
158Partial duplication of the phalanx of hand (HP:0009999)1.64759335
159Protrusio acetabuli (HP:0003179)1.64543485
160Stenosis of the external auditory canal (HP:0000402)1.64152505
161Forearm undergrowth (HP:0009821)1.63677412
162Abnormality of the phalanges of the 5th finger (HP:0004213)1.63595005
163Anhidrosis (HP:0000970)1.62982077
164Renal tubular acidosis (HP:0001947)1.62894761
165Osteolytic defects of the hand bones (HP:0009699)1.62588831
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.62588831
167Abnormality of cells of the lymphoid lineage (HP:0012140)1.62212392
168Anonychia (HP:0001798)1.61666716
169Leukopenia (HP:0001882)1.60771953
170Metaphyseal cupping (HP:0003021)1.60414675
171Pustule (HP:0200039)1.60123187
172Corneal erosion (HP:0200020)1.59216610
173Ventricular tachycardia (HP:0004756)1.58993858
174Abnormal lung lobation (HP:0002101)1.58855719
175Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.58184169
176Abnormality of the gastric mucosa (HP:0004295)1.58088720
177Abnormality of the intervertebral disk (HP:0005108)1.57419408
178Supernumerary bones of the axial skeleton (HP:0009144)1.56463491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.06120926
2EPHA23.37503302
3IRAK32.90479780
4MAP4K12.88037318
5MST42.85441592
6CDK122.81761209
7MET2.76553308
8TLK12.45859113
9RPS6KB22.45597560
10EPHB12.44850209
11MAP3K102.41694310
12ZAK2.20523617
13SMG12.15728486
14MKNK22.14011911
15RIPK12.09586666
16MUSK1.86886400
17LMTK21.77679684
18GRK61.76788775
19MAPK151.76274778
20BLK1.69767651
21PRPF4B1.68177883
22PAK41.67553009
23STK101.66030187
24PIM11.63004178
25PTK21.61763826
26ICK1.60432390
27MATK1.56138636
28SRPK11.55822500
29PRKD21.53309594
30MAPKAPK31.52902883
31TAOK11.50060239
32NME21.49951718
33EEF2K1.48660705
34PTK61.47230546
35BTK1.41763339
36YES11.40633631
37CASK1.38365128
38GRK11.37319627
39HIPK21.34600065
40MAP3K131.30718594
41NLK1.29519835
42MKNK11.28265708
43MAP3K21.23054148
44CDK71.22508440
45MST1R1.21506622
46IKBKB1.20462331
47BMX1.20047273
48DYRK31.18931532
49STK41.18513536
50MAP3K141.18256567
51CDK91.16605106
52BRD41.15102993
53MAP3K91.14786773
54FGFR41.14036063
55NTRK11.11824318
56RIPK41.11722417
57FGFR31.11658714
58STK241.11355831
59MAP3K11.09572835
60ERN11.08330932
61CSF1R1.08166716
62CHUK1.07781910
63SYK1.07378988
64MAP3K31.07105584
65VRK11.06568278
66PASK1.06508789
67TGFBR21.05660168
68EPHB21.05594709
69MARK21.04902356
70LRRK21.04128779
71MAP2K31.02274623
72AKT30.98728398
73PKN20.96978942
74PRKCI0.95876301
75TESK10.95722247
76CDC42BPA0.95047118
77ARAF0.94746993
78JAK30.91490838
79IRAK40.91137714
80MAP3K60.86822793
81TBK10.85903911
82SGK20.84557507
83PDGFRA0.83753649
84CDK30.83532024
85IRAK20.83171552
86SIK30.82939164
87MAP2K20.82042334
88IKBKE0.80707896
89MAP3K110.79677284
90TAOK20.78508688
91TNK20.78381000
92RPS6KA50.77940899
93TTN0.77523479
94TYK20.77340132
95STK380.77097874
96MAP3K70.76346416
97TXK0.75892368
98CDK40.73780063
99WEE10.73732779
100KSR20.70706983
101PDPK10.70052732
102MAPK70.68140919
103ADRBK20.67947254
104LYN0.67123007
105HCK0.66139194
106TGFBR10.66022554
107PRKG20.65737878
108FRK0.65725110
109IRAK10.64797252
110CHEK20.64643103
111AURKB0.64578431
112CLK10.63865747
113TNIK0.63506545
114FGR0.63396795
115MAPKAPK20.63026065
116MTOR0.62746490
117GRK70.62726266
118EIF2AK20.61801613
119MARK30.61694617
120CDK60.61339488
121LATS20.60944802
122TESK20.60817737
123DYRK1B0.60708998
124SIK20.60066920
125SIK10.58721555
126TEC0.58347877
127MAP3K80.57140475
128SGK30.56950760
129TRPM70.56802884
130RPS6KA20.56739536
131LCK0.55449268
132CSK0.55309928
133EPHA30.53690831
134JAK10.51954579
135RPS6KC10.51169332
136RPS6KL10.51169332
137ATR0.48442183
138MAPK30.48105091
139FER0.47548035
140MAPK40.46628952
141RPS6KA60.44433240
142MAPK120.41520401
143MELK0.40839819
144RPS6KA40.39982371
145ZAP700.39267439
146TTK0.38678141
147FLT30.36050709
148TSSK60.35702831
149PDK10.34327807
150PDGFRB0.31998122
151ERBB40.31978959
152MAP2K60.31691414
153PTK2B0.29213865
154RET0.28471247
155ROCK20.27020668

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.31026743
2Primary immunodeficiency_Homo sapiens_hsa053403.12292659
3Mismatch repair_Homo sapiens_hsa034302.27540015
4Non-homologous end-joining_Homo sapiens_hsa034502.07518277
5Fanconi anemia pathway_Homo sapiens_hsa034602.03325582
6B cell receptor signaling pathway_Homo sapiens_hsa046621.99569443
7Transcriptional misregulation in cancer_Homo sapiens_hsa052021.97551802
8Base excision repair_Homo sapiens_hsa034101.92901926
9Hematopoietic cell lineage_Homo sapiens_hsa046401.91418912
10DNA replication_Homo sapiens_hsa030301.80742996
11Homologous recombination_Homo sapiens_hsa034401.69518963
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65612996
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.63629138
14Spliceosome_Homo sapiens_hsa030401.63352137
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.56780012
16RNA polymerase_Homo sapiens_hsa030201.56132980
17p53 signaling pathway_Homo sapiens_hsa041151.51529390
18Fructose and mannose metabolism_Homo sapiens_hsa000511.50022833
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45894171
20Notch signaling pathway_Homo sapiens_hsa043301.45059259
21Systemic lupus erythematosus_Homo sapiens_hsa053221.44318016
22VEGF signaling pathway_Homo sapiens_hsa043701.44052153
23Bladder cancer_Homo sapiens_hsa052191.43880115
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.43697386
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39408875
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39173071
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38840533
28Pancreatic cancer_Homo sapiens_hsa052121.38750110
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36891957
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36671805
31Basal cell carcinoma_Homo sapiens_hsa052171.33497949
32Amoebiasis_Homo sapiens_hsa051461.31341911
33ECM-receptor interaction_Homo sapiens_hsa045121.29246565
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.28548715
35Renal cell carcinoma_Homo sapiens_hsa052111.27934061
36Nucleotide excision repair_Homo sapiens_hsa034201.27369227
37TNF signaling pathway_Homo sapiens_hsa046681.24728201
38Herpes simplex infection_Homo sapiens_hsa051681.23417712
39Non-small cell lung cancer_Homo sapiens_hsa052231.23346251
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23011754
41Arachidonic acid metabolism_Homo sapiens_hsa005901.20843596
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.20463082
43Sulfur relay system_Homo sapiens_hsa041221.18274720
44Focal adhesion_Homo sapiens_hsa045101.15507906
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09460250
46ErbB signaling pathway_Homo sapiens_hsa040121.08780250
47Tuberculosis_Homo sapiens_hsa051521.06585699
48Endometrial cancer_Homo sapiens_hsa052131.05287404
49Basal transcription factors_Homo sapiens_hsa030221.03867617
50Sphingolipid metabolism_Homo sapiens_hsa006001.03186872
51Pyrimidine metabolism_Homo sapiens_hsa002401.02248323
52RNA degradation_Homo sapiens_hsa030181.01426683
53Measles_Homo sapiens_hsa051621.01299052
54Proteoglycans in cancer_Homo sapiens_hsa052050.99640226
55Insulin signaling pathway_Homo sapiens_hsa049100.99031769
56Insulin resistance_Homo sapiens_hsa049310.98763678
57Shigellosis_Homo sapiens_hsa051310.98485113
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98409007
59Endocytosis_Homo sapiens_hsa041440.96574859
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96433629
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96052747
62MicroRNAs in cancer_Homo sapiens_hsa052060.95782343
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94026239
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94016039
65GnRH signaling pathway_Homo sapiens_hsa049120.93937465
66Staphylococcus aureus infection_Homo sapiens_hsa051500.93391347
67Pentose phosphate pathway_Homo sapiens_hsa000300.92892223
68Acute myeloid leukemia_Homo sapiens_hsa052210.92731941
69Small cell lung cancer_Homo sapiens_hsa052220.91815766
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91700207
71Antigen processing and presentation_Homo sapiens_hsa046120.88666723
72Lysosome_Homo sapiens_hsa041420.87559944
73Other glycan degradation_Homo sapiens_hsa005110.87165957
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86154892
75Viral carcinogenesis_Homo sapiens_hsa052030.86101624
76Renin-angiotensin system_Homo sapiens_hsa046140.84067520
77Salmonella infection_Homo sapiens_hsa051320.83640603
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83403668
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83013184
80Galactose metabolism_Homo sapiens_hsa000520.82833385
81HTLV-I infection_Homo sapiens_hsa051660.82551279
82Cell cycle_Homo sapiens_hsa041100.82476695
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.82412648
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82218693
85mRNA surveillance pathway_Homo sapiens_hsa030150.81557848
86Mineral absorption_Homo sapiens_hsa049780.81484526
87Choline metabolism in cancer_Homo sapiens_hsa052310.80768943
88Malaria_Homo sapiens_hsa051440.80137392
89Hedgehog signaling pathway_Homo sapiens_hsa043400.80076657
90RNA transport_Homo sapiens_hsa030130.79623037
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.77671845
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.77197870
93Epstein-Barr virus infection_Homo sapiens_hsa051690.77020940
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76863872
95mTOR signaling pathway_Homo sapiens_hsa041500.76123353
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75513724
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75423188
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75355757
99Chemokine signaling pathway_Homo sapiens_hsa040620.72717265
100Apoptosis_Homo sapiens_hsa042100.71222605
101Prion diseases_Homo sapiens_hsa050200.70931883
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.70813374
103Estrogen signaling pathway_Homo sapiens_hsa049150.70038810
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.69182607
105Alcoholism_Homo sapiens_hsa050340.69130846
106Pathways in cancer_Homo sapiens_hsa052000.68764232
107Pertussis_Homo sapiens_hsa051330.68052800
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.67837478
109Glioma_Homo sapiens_hsa052140.67107693
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66906116
111Influenza A_Homo sapiens_hsa051640.66505701
112African trypanosomiasis_Homo sapiens_hsa051430.66329218
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.64642420
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.64288217
115Osteoclast differentiation_Homo sapiens_hsa043800.63453881
116HIF-1 signaling pathway_Homo sapiens_hsa040660.63247287
117Folate biosynthesis_Homo sapiens_hsa007900.62713433
118One carbon pool by folate_Homo sapiens_hsa006700.61957880
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61107121
120Wnt signaling pathway_Homo sapiens_hsa043100.59712591
121T cell receptor signaling pathway_Homo sapiens_hsa046600.59229552
122Bile secretion_Homo sapiens_hsa049760.57782322
123Toxoplasmosis_Homo sapiens_hsa051450.57533408
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57369765
125Phagosome_Homo sapiens_hsa041450.56579477
126Prostate cancer_Homo sapiens_hsa052150.56486571
127Rap1 signaling pathway_Homo sapiens_hsa040150.56109417
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54545327
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54426346
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54143514
131Viral myocarditis_Homo sapiens_hsa054160.53999061
132Leishmaniasis_Homo sapiens_hsa051400.52734437
133Vitamin digestion and absorption_Homo sapiens_hsa049770.51822369
134Tight junction_Homo sapiens_hsa045300.50396152
135Thyroid cancer_Homo sapiens_hsa052160.50213945
136Hepatitis B_Homo sapiens_hsa051610.49349035
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49311431
138Hepatitis C_Homo sapiens_hsa051600.49259536
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47676185
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47605062
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47086929
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46412892
143Adherens junction_Homo sapiens_hsa045200.45929844
144Hippo signaling pathway_Homo sapiens_hsa043900.45903805
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45835958
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45265920
147Circadian rhythm_Homo sapiens_hsa047100.44251556
148Purine metabolism_Homo sapiens_hsa002300.44199177
149AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44099709
150Fatty acid biosynthesis_Homo sapiens_hsa000610.42870555
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42378674
152Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41472551
153Chronic myeloid leukemia_Homo sapiens_hsa052200.41325607
154Platelet activation_Homo sapiens_hsa046110.40165630
155Linoleic acid metabolism_Homo sapiens_hsa005910.38879331
156Prolactin signaling pathway_Homo sapiens_hsa049170.38827056
157Inositol phosphate metabolism_Homo sapiens_hsa005620.36307934

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