SEMA4F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.03082686
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.71848654
3locomotory exploration behavior (GO:0035641)5.36201308
4synaptic vesicle maturation (GO:0016188)5.23784111
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.03190253
6vocalization behavior (GO:0071625)4.89027596
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.88073727
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.83065381
9synaptic vesicle exocytosis (GO:0016079)4.82168617
10pyrimidine nucleobase catabolic process (GO:0006208)4.80061415
11neuron cell-cell adhesion (GO:0007158)4.71886239
12regulation of synaptic vesicle exocytosis (GO:2000300)4.59403400
13glutamate secretion (GO:0014047)4.54219731
14neuronal action potential propagation (GO:0019227)4.45855356
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.43733064
16protein localization to synapse (GO:0035418)4.43276787
17regulation of glutamate receptor signaling pathway (GO:1900449)4.36780277
18exploration behavior (GO:0035640)4.33828359
19dendritic spine morphogenesis (GO:0060997)4.05923863
20layer formation in cerebral cortex (GO:0021819)4.04562018
21transmission of nerve impulse (GO:0019226)4.04244295
22regulation of synaptic vesicle transport (GO:1902803)4.01554085
23synaptic transmission, glutamatergic (GO:0035249)3.97026777
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.96032814
25nucleobase catabolic process (GO:0046113)3.95660328
26glutamate receptor signaling pathway (GO:0007215)3.93122539
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.89074263
28neurotransmitter secretion (GO:0007269)3.82178552
29regulation of neuronal synaptic plasticity (GO:0048168)3.81747496
30neuron recognition (GO:0008038)3.77866995
31cell migration in hindbrain (GO:0021535)3.77525227
32positive regulation of membrane potential (GO:0045838)3.72680455
33positive regulation of gastrulation (GO:2000543)3.70339290
34cerebellar granule cell differentiation (GO:0021707)3.68492162
35neuron-neuron synaptic transmission (GO:0007270)3.63970247
36synaptic vesicle endocytosis (GO:0048488)3.60918502
37presynaptic membrane assembly (GO:0097105)3.59255173
38dendrite morphogenesis (GO:0048813)3.56015719
39axonal fasciculation (GO:0007413)3.52876332
40regulation of synapse structural plasticity (GO:0051823)3.52001196
41neuronal ion channel clustering (GO:0045161)3.50925392
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49448767
43L-fucose catabolic process (GO:0042355)3.48513868
44fucose catabolic process (GO:0019317)3.48513868
45L-fucose metabolic process (GO:0042354)3.48513868
46gamma-aminobutyric acid transport (GO:0015812)3.47178020
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45212790
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.43408300
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.41882471
50presynaptic membrane organization (GO:0097090)3.40810110
51response to pheromone (GO:0019236)3.40367317
52proline transport (GO:0015824)3.39355575
53cerebellar Purkinje cell differentiation (GO:0021702)3.36702450
54regulation of dendritic spine morphogenesis (GO:0061001)3.35882793
55long-term memory (GO:0007616)3.35237678
56regulation of postsynaptic membrane potential (GO:0060078)3.34389974
57auditory behavior (GO:0031223)3.31792336
58startle response (GO:0001964)3.28495313
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25165506
60regulation of neurotransmitter secretion (GO:0046928)3.23499657
61neurofilament cytoskeleton organization (GO:0060052)3.22679842
62cellular potassium ion homeostasis (GO:0030007)3.21023805
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18398685
64neurotransmitter transport (GO:0006836)3.17825632
65neuromuscular process controlling balance (GO:0050885)3.16550368
66adult walking behavior (GO:0007628)3.16468657
67postsynaptic membrane organization (GO:0001941)3.16233387
68water-soluble vitamin biosynthetic process (GO:0042364)3.15954565
69regulation of synaptic plasticity (GO:0048167)3.14100122
70positive regulation of synapse maturation (GO:0090129)3.11074512
71membrane hyperpolarization (GO:0060081)3.11068070
72protein polyglutamylation (GO:0018095)3.08414572
73neurotransmitter-gated ion channel clustering (GO:0072578)3.07948336
74vesicle transport along microtubule (GO:0047496)3.07600336
75regulation of vesicle fusion (GO:0031338)3.07581322
76nonmotile primary cilium assembly (GO:0035058)3.06041164
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.04054476
78positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99596527
79piRNA metabolic process (GO:0034587)2.98782509
80protein localization to cilium (GO:0061512)2.98330193
81neuromuscular process controlling posture (GO:0050884)2.98188741
82synapse assembly (GO:0007416)2.96667920
83membrane depolarization (GO:0051899)2.96593974
84negative regulation of microtubule polymerization (GO:0031115)2.94670738
85organelle transport along microtubule (GO:0072384)2.93792952
86dendritic spine organization (GO:0097061)2.93635073
87membrane depolarization during action potential (GO:0086010)2.93338404
88negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92351879
89regulation of neurotransmitter levels (GO:0001505)2.91873968
90activation of protein kinase A activity (GO:0034199)2.91325570
91synapse organization (GO:0050808)2.91228097
92regulation of dendritic spine development (GO:0060998)2.90996837
93primary amino compound metabolic process (GO:1901160)2.90652007
94glycerophospholipid catabolic process (GO:0046475)2.90597889
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90139135
96membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89193823
97regulation of neurotransmitter transport (GO:0051588)2.88693694
98negative regulation of axon guidance (GO:1902668)2.87867815
99regulation of dendrite morphogenesis (GO:0048814)2.87845655
100long-term synaptic potentiation (GO:0060291)2.87386567
101learning (GO:0007612)2.86434877
102* retinal ganglion cell axon guidance (GO:0031290)2.85220537
103cerebral cortex radially oriented cell migration (GO:0021799)2.84248574
104synaptic transmission, cholinergic (GO:0007271)2.81466222
105central nervous system projection neuron axonogenesis (GO:0021952)2.81436332
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81241660
107nerve growth factor signaling pathway (GO:0038180)2.81019872
108positive regulation of dendritic spine development (GO:0060999)2.78662213
109glycosphingolipid biosynthetic process (GO:0006688)2.78498091
110behavioral response to ethanol (GO:0048149)2.77951018
111ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.77832481
112cell differentiation in hindbrain (GO:0021533)2.77630596
113negative regulation of neurotransmitter transport (GO:0051589)2.77619186
114regulation of voltage-gated calcium channel activity (GO:1901385)2.77559092
115cornea development in camera-type eye (GO:0061303)2.77098257
116behavioral fear response (GO:0001662)2.76776483
117behavioral defense response (GO:0002209)2.76776483
118mating behavior (GO:0007617)2.76645776
119sodium ion export (GO:0071436)2.75784177
120neuronal action potential (GO:0019228)2.75634544
121chemosensory behavior (GO:0007635)2.75193347
122regulation of synaptic transmission (GO:0050804)2.75128345
123positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.74895522
124regulation of cell communication by electrical coupling (GO:0010649)2.74879640
125serotonin metabolic process (GO:0042428)2.69475553
126establishment of mitochondrion localization (GO:0051654)2.67029146
127indolalkylamine metabolic process (GO:0006586)2.66875119
128nephron epithelium morphogenesis (GO:0072088)2.65139496
129nephron tubule morphogenesis (GO:0072078)2.65139496
130anterograde axon cargo transport (GO:0008089)2.63895510
131neuromuscular synaptic transmission (GO:0007274)2.62502364
132head development (GO:0060322)2.59950392
133negative regulation of telomere maintenance (GO:0032205)2.57387367
134positive regulation of synapse assembly (GO:0051965)2.57279471
135positive regulation of dendritic spine morphogenesis (GO:0061003)2.56222908
136calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.55976551
137establishment of protein localization to mitochondrial membrane (GO:0090151)2.53342642
138regulation of respiratory system process (GO:0044065)2.52067245
139fear response (GO:0042596)2.51941971
140detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50936000
141regulation of action potential (GO:0098900)2.50559793
142cilium morphogenesis (GO:0060271)2.50274132
143retinal cone cell development (GO:0046549)2.47908778
144kynurenine metabolic process (GO:0070189)2.47674304
145mechanosensory behavior (GO:0007638)2.47097939
146anterograde synaptic vesicle transport (GO:0048490)2.44730031
147detection of light stimulus involved in visual perception (GO:0050908)2.44347324
148detection of light stimulus involved in sensory perception (GO:0050962)2.44347324
149negative regulation of axon extension involved in axon guidance (GO:0048843)2.44331258
150cellular ketone body metabolic process (GO:0046950)2.43867621
151peristalsis (GO:0030432)2.42940525
152axon extension (GO:0048675)2.39421804
153indole-containing compound metabolic process (GO:0042430)2.39181577
154inner ear receptor stereocilium organization (GO:0060122)2.38854849
155protein-cofactor linkage (GO:0018065)2.38398344
156intraciliary transport (GO:0042073)2.37954961
157action potential (GO:0001508)2.34802128
158adult behavior (GO:0030534)2.34225455
159short-term memory (GO:0007614)2.33895282
160axon cargo transport (GO:0008088)2.33832454
161regulation of axon guidance (GO:1902667)2.33677425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22056413
2GBX2_23144817_ChIP-Seq_PC3_Human3.54900395
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16874765
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10250675
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06582874
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74081508
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74081508
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63875789
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.63163556
10DROSHA_22980978_ChIP-Seq_HELA_Human2.59551299
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.57265389
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56085872
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55734691
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52367524
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48768778
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46852223
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.34547057
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.29949913
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29232175
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.28331655
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.21172127
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.09212962
23AR_21572438_ChIP-Seq_LNCaP_Human2.06059888
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98989105
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89866344
26IGF1R_20145208_ChIP-Seq_DFB_Human1.87531838
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85717386
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85290515
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84289840
30TAF15_26573619_Chip-Seq_HEK293_Human1.80214827
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75430732
32FUS_26573619_Chip-Seq_HEK293_Human1.74104687
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73114093
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70872394
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70184815
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61001500
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57274967
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57131253
39SMAD4_21799915_ChIP-Seq_A2780_Human1.53563692
40EWS_26573619_Chip-Seq_HEK293_Human1.52945500
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51627526
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48824009
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45263529
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44760279
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.43149896
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42204895
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.42087942
48TP53_22573176_ChIP-Seq_HFKS_Human1.39860365
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39052012
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39029591
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38995727
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38224252
53P300_19829295_ChIP-Seq_ESCs_Human1.37924202
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34143959
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.33935974
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31994437
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.29951196
58ZNF274_21170338_ChIP-Seq_K562_Hela1.29176913
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.29069869
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27128672
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26432251
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.26325791
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.26099291
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25803906
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24522257
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24401553
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23155506
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22190896
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22042286
70STAT3_23295773_ChIP-Seq_U87_Human1.21923727
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21354351
72RNF2_27304074_Chip-Seq_NSC_Mouse1.19757003
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17855516
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17403891
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.17024353
76CBP_20019798_ChIP-Seq_JUKART_Human1.16987287
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16987287
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16922471
79AR_19668381_ChIP-Seq_PC3_Human1.16085356
80AR_25329375_ChIP-Seq_VCAP_Human1.15137488
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14607641
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14580598
83MYC_18940864_ChIP-ChIP_HL60_Human1.13556626
84BCAT_22108803_ChIP-Seq_LS180_Human1.13111466
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.12870425
86AHR_22903824_ChIP-Seq_MCF-7_Human1.12510099
87IRF1_19129219_ChIP-ChIP_H3396_Human1.12159900
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.11564249
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10703815
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10657161
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10367381
92* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08651758
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06253058
94* TCF4_23295773_ChIP-Seq_U87_Human1.06239445
95* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05889183
96* KDM2B_26808549_Chip-Seq_K562_Human1.05730448
97TP53_16413492_ChIP-PET_HCT116_Human1.03645069
98ER_23166858_ChIP-Seq_MCF-7_Human1.02825922
99* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01577789
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.01269879
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01059832
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00298788
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.99782365
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99781593
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99651862
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98763278
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98546638
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98167008
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.98163696
110* RUNX2_22187159_ChIP-Seq_PCA_Human0.97273041
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97164045
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96848738
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96800456
114RXR_22108803_ChIP-Seq_LS180_Human0.96647222
115TP53_20018659_ChIP-ChIP_R1E_Mouse0.96298028
116FLI1_21867929_ChIP-Seq_TH2_Mouse0.95551117
117SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94441518
118TCF4_22108803_ChIP-Seq_LS180_Human0.94178436
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93106103
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92148764
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92148764
122GABP_17652178_ChIP-ChIP_JURKAT_Human0.91905782
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91403128
124* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91301043
125ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90864186
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.90353532
127JUN_21703547_ChIP-Seq_K562_Human0.87853131
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86677761
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85925330
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.85759757
131VDR_22108803_ChIP-Seq_LS180_Human0.85095256
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82974753
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82420624

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.07488704
2MP0003880_abnormal_central_pattern4.72723155
3MP0004270_analgesia4.08133993
4MP0003635_abnormal_synaptic_transmissio3.94630921
5MP0009745_abnormal_behavioral_response3.27983134
6MP0001968_abnormal_touch/_nociception3.21042632
7MP0002063_abnormal_learning/memory/cond3.10789828
8MP0002064_seizures3.09635688
9MP0009046_muscle_twitch3.04250805
10MP0002735_abnormal_chemical_nociception3.00210446
11MP0002734_abnormal_mechanical_nocicepti2.89414638
12MP0005423_abnormal_somatic_nervous2.82469127
13MP0002272_abnormal_nervous_system2.80098522
14MP0002572_abnormal_emotion/affect_behav2.71748086
15MP0001486_abnormal_startle_reflex2.60048483
16MP0002736_abnormal_nociception_after2.49011948
17MP0001440_abnormal_grooming_behavior2.44454817
18MP0002733_abnormal_thermal_nociception2.37484328
19MP0000778_abnormal_nervous_system2.26276649
20MP0008877_abnormal_DNA_methylation2.19176372
21MP0001970_abnormal_pain_threshold2.19102463
22MP0003329_amyloid_beta_deposits2.18175702
23MP0006276_abnormal_autonomic_nervous2.17490754
24MP0002184_abnormal_innervation2.14343322
25MP0004858_abnormal_nervous_system2.09396202
26MP0002067_abnormal_sensory_capabilities2.05197901
27MP0002822_catalepsy2.02865402
28MP0002102_abnormal_ear_morphology2.00828053
29MP0001501_abnormal_sleep_pattern1.97261099
30MP0005386_behavior/neurological_phenoty1.87592702
31MP0004924_abnormal_behavior1.87592702
32MP0002653_abnormal_ependyma_morphology1.86864911
33MP0004133_heterotaxia1.84133142
34MP0004885_abnormal_endolymph1.81218599
35MP0008569_lethality_at_weaning1.80567756
36MP0004811_abnormal_neuron_physiology1.79108382
37MP0002557_abnormal_social/conspecific_i1.76598446
38MP0000955_abnormal_spinal_cord1.74271498
39MP0003121_genomic_imprinting1.74133953
40MP0000920_abnormal_myelination1.73670930
41MP0002938_white_spotting1.71123526
42MP0006292_abnormal_olfactory_placode1.65856639
43MP0002882_abnormal_neuron_morphology1.58986880
44MP0003136_yellow_coat_color1.57171591
45MP0004742_abnormal_vestibular_system1.57004293
46MP0001984_abnormal_olfaction1.54579301
47MP0002066_abnormal_motor_capabilities/c1.51993680
48MP0000569_abnormal_digit_pigmentation1.50842062
49MP0001529_abnormal_vocalization1.50305629
50MP0002928_abnormal_bile_duct1.50199313
51MP0004142_abnormal_muscle_tone1.47814801
52MP0005645_abnormal_hypothalamus_physiol1.45350497
53MP0001905_abnormal_dopamine_level1.42246788
54MP0003890_abnormal_embryonic-extraembry1.39468224
55MP0003283_abnormal_digestive_organ1.39204354
56MP0009780_abnormal_chondrocyte_physiolo1.38225128
57MP0003879_abnormal_hair_cell1.34791443
58MP0005084_abnormal_gallbladder_morpholo1.29313900
59MP0003633_abnormal_nervous_system1.25332739
60MP0001485_abnormal_pinna_reflex1.25187878
61MP0003195_calcinosis1.22779349
62MP0002234_abnormal_pharynx_morphology1.22407716
63MP0003634_abnormal_glial_cell1.20579637
64MP0002229_neurodegeneration1.20465398
65MP0003631_nervous_system_phenotype1.18806300
66MP0000427_abnormal_hair_cycle1.18071392
67MP0001502_abnormal_circadian_rhythm1.17569936
68MP0002152_abnormal_brain_morphology1.17044041
69MP0005253_abnormal_eye_physiology1.14338761
70MP0003690_abnormal_glial_cell1.14189184
71MP0005646_abnormal_pituitary_gland1.14139466
72MP0003123_paternal_imprinting1.12763901
73MP0002160_abnormal_reproductive_system1.11730839
74MP0008875_abnormal_xenobiotic_pharmacok1.11041033
75MP0000372_irregular_coat_pigmentation1.11030780
76MP0002909_abnormal_adrenal_gland1.09954059
77MP0003632_abnormal_nervous_system1.09588326
78MP0000566_synostosis1.07928521
79MP0002876_abnormal_thyroid_physiology1.07118480
80MP0001177_atelectasis1.02788967
81MP0005195_abnormal_posterior_eye1.02417511
82MP0002752_abnormal_somatic_nervous0.99461227
83MP0000604_amyloidosis0.97970824
84MP0003122_maternal_imprinting0.97513788
85MP0003937_abnormal_limbs/digits/tail_de0.96513618
86MP0000538_abnormal_urinary_bladder0.95397914
87MP0005389_reproductive_system_phenotype0.94073146
88MP0001963_abnormal_hearing_physiology0.93433979
89MP0003787_abnormal_imprinting0.93304367
90MP0003878_abnormal_ear_physiology0.93221324
91MP0005377_hearing/vestibular/ear_phenot0.93221324
92MP0008874_decreased_physiological_sensi0.92417769
93MP0005187_abnormal_penis_morphology0.90733169
94MP0003942_abnormal_urinary_system0.90150484
95MP0000647_abnormal_sebaceous_gland0.88087801
96MP0008789_abnormal_olfactory_epithelium0.87768199
97MP0000049_abnormal_middle_ear0.86585463
98MP0005551_abnormal_eye_electrophysiolog0.86334985
99MP0003119_abnormal_digestive_system0.85187088
100MP0002069_abnormal_eating/drinking_beha0.84796085
101MP0001348_abnormal_lacrimal_gland0.82719239
102MP0001299_abnormal_eye_distance/0.82435232
103MP0004145_abnormal_muscle_electrophysio0.80264469
104MP0005409_darkened_coat_color0.77615323
105MP0000631_abnormal_neuroendocrine_gland0.76241356
106MP0008872_abnormal_physiological_respon0.75091002
107MP0001188_hyperpigmentation0.74922465
108MP0004085_abnormal_heartbeat0.71735417
109MP0004510_myositis0.71347304
110MP0003861_abnormal_nervous_system0.70218688
111MP0005171_absent_coat_pigmentation0.65960115
112MP0005499_abnormal_olfactory_system0.65881487
113MP0005394_taste/olfaction_phenotype0.65881487
114MP0010386_abnormal_urinary_bladder0.65826249
115MP0001664_abnormal_digestion0.65585428
116MP0001943_abnormal_respiration0.64411966
117MP0000751_myopathy0.64113313
118MP0002751_abnormal_autonomic_nervous0.63018486
119MP0005623_abnormal_meninges_morphology0.61264350
120MP0003137_abnormal_impulse_conducting0.60262415
121MP0000026_abnormal_inner_ear0.58319917
122MP0010769_abnormal_survival0.56296070
123MP0002082_postnatal_lethality0.54044682
124MP0010770_preweaning_lethality0.54044682
125MP0010768_mortality/aging0.53111757
126MP0003075_altered_response_to0.51309446
127MP0003956_abnormal_body_size0.49835836
128MP0005535_abnormal_body_temperature0.49490992
129MP0003938_abnormal_ear_development0.48532881
130MP0006072_abnormal_retinal_apoptosis0.46272538
131MP0002638_abnormal_pupillary_reflex0.44925009
132MP0001986_abnormal_taste_sensitivity0.44917047
133MP0002837_dystrophic_cardiac_calcinosis0.44543661
134MP0000747_muscle_weakness0.42993087
135MP0002090_abnormal_vision0.41322175

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.50208110
2Focal motor seizures (HP:0011153)6.41175176
3Focal seizures (HP:0007359)5.39442981
4Atonic seizures (HP:0010819)5.12877600
5Supranuclear gaze palsy (HP:0000605)4.70119282
6Visual hallucinations (HP:0002367)4.65838051
7Epileptic encephalopathy (HP:0200134)4.33568745
8Action tremor (HP:0002345)4.32136945
9Febrile seizures (HP:0002373)4.29967173
10Progressive cerebellar ataxia (HP:0002073)4.22976383
11Abnormality of midbrain morphology (HP:0002418)4.22711936
12Molar tooth sign on MRI (HP:0002419)4.22711936
13Absence seizures (HP:0002121)3.97414882
14Abnormality of the corticospinal tract (HP:0002492)3.83686829
15Type II lissencephaly (HP:0007260)3.79412965
16Pancreatic fibrosis (HP:0100732)3.71820898
17Neurofibrillary tangles (HP:0002185)3.65524343
18Dialeptic seizures (HP:0011146)3.63992863
19Pancreatic cysts (HP:0001737)3.59149173
20True hermaphroditism (HP:0010459)3.51937354
21Nephronophthisis (HP:0000090)3.36143070
22Broad-based gait (HP:0002136)3.30442114
23Termporal pattern (HP:0011008)3.27133976
24Insidious onset (HP:0003587)3.27133976
25Generalized tonic-clonic seizures (HP:0002069)3.26315566
26Cerebral inclusion bodies (HP:0100314)3.25045435
27Ankle clonus (HP:0011448)3.24140912
28Spastic gait (HP:0002064)3.22481888
29Dysmetria (HP:0001310)3.17701817
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.16005626
31Degeneration of the lateral corticospinal tracts (HP:0002314)3.16005626
32Gaze-evoked nystagmus (HP:0000640)3.13048976
33Chronic hepatic failure (HP:0100626)3.01911665
34Akinesia (HP:0002304)3.01306400
35Urinary bladder sphincter dysfunction (HP:0002839)2.99285983
36Medial flaring of the eyebrow (HP:0010747)2.98826239
37Hyperventilation (HP:0002883)2.94623375
38Poor eye contact (HP:0000817)2.91547454
39Scanning speech (HP:0002168)2.88197255
40Gait imbalance (HP:0002141)2.87258223
41Intention tremor (HP:0002080)2.86760700
42Truncal ataxia (HP:0002078)2.85969717
43Abnormal eating behavior (HP:0100738)2.83701572
44Abnormality of the renal medulla (HP:0100957)2.81463401
45Sensory axonal neuropathy (HP:0003390)2.81418290
46Lissencephaly (HP:0001339)2.79824651
47Impaired vibration sensation in the lower limbs (HP:0002166)2.76362734
48Sclerocornea (HP:0000647)2.70069031
49Fetal akinesia sequence (HP:0001989)2.69663257
50Mutism (HP:0002300)2.69217809
51Abnormal social behavior (HP:0012433)2.68154107
52Impaired social interactions (HP:0000735)2.68154107
53Amblyopia (HP:0000646)2.67902749
54Dysdiadochokinesis (HP:0002075)2.67040186
55Progressive inability to walk (HP:0002505)2.67020229
56Anxiety (HP:0000739)2.66843691
57Urinary urgency (HP:0000012)2.64117404
58Cystic liver disease (HP:0006706)2.62432217
59Cerebellar dysplasia (HP:0007033)2.57888984
60Pendular nystagmus (HP:0012043)2.57460957
61Excessive salivation (HP:0003781)2.56862119
62Drooling (HP:0002307)2.56862119
63Depression (HP:0000716)2.53105225
64Congenital stationary night blindness (HP:0007642)2.52273121
65Occipital encephalocele (HP:0002085)2.50098826
66Megalencephaly (HP:0001355)2.48863153
67Postural instability (HP:0002172)2.47473151
68Abnormality of binocular vision (HP:0011514)2.44462035
69Diplopia (HP:0000651)2.44462035
70Pachygyria (HP:0001302)2.43542704
71Congenital primary aphakia (HP:0007707)2.43293769
72Absent speech (HP:0001344)2.35014126
73Stereotypic behavior (HP:0000733)2.34665074
74Lower limb muscle weakness (HP:0007340)2.34172421
75Pheochromocytoma (HP:0002666)2.34019035
76Abnormality of the renal cortex (HP:0011035)2.33389179
77Anencephaly (HP:0002323)2.31592898
78Hemiparesis (HP:0001269)2.28607320
79Genetic anticipation (HP:0003743)2.24857899
80Amyotrophic lateral sclerosis (HP:0007354)2.23813904
81Aqueductal stenosis (HP:0002410)2.23788651
82Nephrogenic diabetes insipidus (HP:0009806)2.23450022
83Limb dystonia (HP:0002451)2.23076988
84Polyphagia (HP:0002591)2.22833926
85Oligodactyly (hands) (HP:0001180)2.20994544
86Parakeratosis (HP:0001036)2.20650916
87Peripheral hypomyelination (HP:0007182)2.19141117
88Abnormality of the lower motor neuron (HP:0002366)2.17923822
89Abnormal drinking behavior (HP:0030082)2.16442500
90Polydipsia (HP:0001959)2.16442500
91Hypomagnesemia (HP:0002917)2.15523972
92Optic nerve hypoplasia (HP:0000609)2.15072233
93Papilledema (HP:0001085)2.13507008
94Increased corneal curvature (HP:0100692)2.13193203
95Keratoconus (HP:0000563)2.13193203
96Anophthalmia (HP:0000528)2.13088517
97Polyuria (HP:0000103)2.12529079
98Retinal dysplasia (HP:0007973)2.11899830
99Genital tract atresia (HP:0001827)2.11279657
100Severe muscular hypotonia (HP:0006829)2.10885904
101Aplasia/Hypoplasia of the brainstem (HP:0007362)2.10256430
102Hypoplasia of the brainstem (HP:0002365)2.10256430
103Aplasia/Hypoplasia of the tongue (HP:0010295)2.09136451
104Epileptiform EEG discharges (HP:0011182)2.08694928
105Narrow forehead (HP:0000341)2.07247925
106Impaired smooth pursuit (HP:0007772)2.06752208
107Generalized myoclonic seizures (HP:0002123)2.03884203
108Hypoplasia of the pons (HP:0012110)2.03843795
109EEG with generalized epileptiform discharges (HP:0011198)2.03187883
110Inability to walk (HP:0002540)2.02669844
111Vaginal atresia (HP:0000148)2.02273800
112Bony spicule pigmentary retinopathy (HP:0007737)2.00955952
113Neuroendocrine neoplasm (HP:0100634)1.99207907
114Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97718062
115Abnormal rod and cone electroretinograms (HP:0008323)1.96263515
116Concave nail (HP:0001598)1.95449852
117Hypothermia (HP:0002045)1.95043318
118Bradykinesia (HP:0002067)1.93451698
119Morphological abnormality of the pyramidal tract (HP:0002062)1.93204127
120Patellar aplasia (HP:0006443)1.92869594
121Hypsarrhythmia (HP:0002521)1.92772247
122Tubular atrophy (HP:0000092)1.91378547
123Abnormality of the pons (HP:0007361)1.91282295
124Torticollis (HP:0000473)1.91132059
125Abnormality of salivation (HP:0100755)1.89337839
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88862487
127Thickened helices (HP:0000391)1.88159749
128Shawl scrotum (HP:0000049)1.88109286
129Ulnar claw (HP:0001178)1.88073669
130Hemiplegia (HP:0002301)1.87568622
131Agitation (HP:0000713)1.87303119
132Attenuation of retinal blood vessels (HP:0007843)1.86562158
133Psychosis (HP:0000709)1.86560343
134Congenital hepatic fibrosis (HP:0002612)1.86446219
135Clonus (HP:0002169)1.86445454
136Aplasia/Hypoplasia of the patella (HP:0006498)1.86200332
137Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85362477
138Hyperglycinemia (HP:0002154)1.84011296
139Abnormality of ocular smooth pursuit (HP:0000617)1.83794214
140Gait ataxia (HP:0002066)1.82719806
141Postaxial hand polydactyly (HP:0001162)1.82581387
142Abnormality of the labia minora (HP:0012880)1.82413927
143Blue irides (HP:0000635)1.82172521
144Methylmalonic acidemia (HP:0002912)1.81098266
145Insomnia (HP:0100785)1.80959671
146Spastic tetraplegia (HP:0002510)1.80825248
147Supernumerary spleens (HP:0009799)1.80318183
148Specific learning disability (HP:0001328)1.79224876
149Acute necrotizing encephalopathy (HP:0006965)1.79185558
150Optic disc pallor (HP:0000543)1.78848539
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.78742134
152Postaxial foot polydactyly (HP:0001830)1.78624303
153Furrowed tongue (HP:0000221)1.77787037
154Rapidly progressive (HP:0003678)1.76773689
155Lower limb asymmetry (HP:0100559)1.76374902
156Thyroid-stimulating hormone excess (HP:0002925)1.75629787
157Abnormality of saccadic eye movements (HP:0000570)1.75201973
158Preaxial hand polydactyly (HP:0001177)1.74728731
159Abnormal hair whorl (HP:0010721)1.74135205
160Delayed CNS myelination (HP:0002188)1.73126477
161Abnormal pancreas size (HP:0012094)1.72588105
162Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72490117
163Abnormality of alanine metabolism (HP:0010916)1.72490117
164Hyperalaninemia (HP:0003348)1.72490117
165Onion bulb formation (HP:0003383)1.71569001
166Focal dystonia (HP:0004373)1.71255716
167Impaired vibratory sensation (HP:0002495)1.70419143
168Status epilepticus (HP:0002133)1.70235198
169Abnormality of magnesium homeostasis (HP:0004921)1.69456064
170Hammertoe (HP:0001765)1.69158784
171Mitochondrial inheritance (HP:0001427)1.68606393
172Steppage gait (HP:0003376)1.68561844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.14277191
2MAP3K93.99308289
3MARK13.59474985
4FRK3.45897260
5EPHA43.18441275
6BMPR1B2.75090409
7TNIK2.71717391
8MINK12.65478426
9MAP3K42.53921324
10PINK12.48248790
11WNK32.47906403
12ADRBK22.47419271
13PAK62.43722218
14NTRK12.13662228
15MAP3K122.05923808
16KSR22.05892713
17MAP2K71.98375831
18NTRK21.95815794
19TLK11.87539759
20STK391.87328262
21CDK191.87123622
22DAPK21.86975639
23OXSR11.72352973
24TRIM281.66074456
25MAPK131.64826362
26UHMK11.59104856
27PNCK1.58688282
28MAP2K41.57619809
29GRK11.55426260
30PRPF4B1.54136427
31CDK51.53672215
32SIK21.52754509
33ARAF1.43384089
34INSRR1.43233670
35TYRO31.41035774
36CASK1.37711397
37GRK51.37367691
38KSR11.34038799
39ADRBK11.33133300
40FGFR21.26546524
41ZAK1.25758321
42CAMKK11.25690849
43PHKG21.21835127
44PHKG11.21835127
45MAP3K21.21823393
46NUAK11.21528306
47RIPK41.21203994
48STK161.18713384
49MAP3K131.14444797
50LIMK11.11647287
51CSNK1G21.10152366
52WNK11.08575859
53FES1.08371096
54PRKCG1.08214106
55ICK1.06249425
56PAK31.02689980
57MARK21.00523482
58CDK141.00338013
59PLK20.98628384
60EPHB20.96955780
61PRKD30.96093397
62MKNK20.96012684
63BCR0.95723806
64CAMK2A0.94650988
65DAPK10.94192663
66MAP4K20.93494640
67CDK180.92900627
68STK110.92546552
69CDK150.92365937
70LATS20.92075390
71CAMK2B0.90782816
72ACVR1B0.90514487
73RET0.89434232
74CAMKK20.86053296
75SGK4940.85998019
76SGK2230.85998019
77SIK30.82951653
78CDK11A0.82001227
79CSNK1G30.81272577
80STK380.80224486
81LMTK20.79077161
82FGR0.76338689
83TAOK10.75872818
84ROCK20.75634148
85CSNK1A1L0.74141482
86PRKCH0.72624962
87PKN10.72497111
88CAMK10.68937002
89ALK0.66308066
90NEK60.65506340
91WNK40.65499988
92PRKCI0.64979935
93FYN0.64481814
94DYRK1A0.64337515
95RAF10.61672895
96PTK2B0.58967347
97BRSK10.55797436
98SGK10.54595357
99CAMK2D0.53939918
100TGFBR10.53769225
101DYRK30.53470042
102PDPK10.52913156
103EPHB10.52650870
104CAMK2G0.51719680
105PDK10.50190804
106NEK20.49822221
107TNK20.48875513
108PRKCE0.48483344
109CAMK1D0.47959176
110SGK20.46526141
111PRKACA0.45467896
112PRKCZ0.45172289
113CSNK1G10.45107761
114TAF10.43963647
115DYRK20.42685798
116WEE10.42481129
117MAP3K10.41983954
118PRKCQ0.41788915
119MET0.40249449
120CAMK1G0.39798184
121SGK30.38886446
122CSNK1D0.38693477
123PASK0.38656730
124CSNK1A10.38173198
125MAP2K60.37895466
126CSNK1E0.37415458
127PRKAA10.37124610
128RPS6KA30.36948890
129BMPR20.35053470
130PIK3CA0.34181430
131MAPK150.34047876
132MAPK100.33875835
133CDC42BPA0.33484089
134GRK70.32727679
135PRKCA0.30237312
136PRKG10.29940827
137BCKDK0.29867440

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.42320427
2Synaptic vesicle cycle_Homo sapiens_hsa047213.03260499
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58032147
4Glutamatergic synapse_Homo sapiens_hsa047242.57001870
5Long-term potentiation_Homo sapiens_hsa047202.48955819
6Circadian entrainment_Homo sapiens_hsa047132.45711362
7GABAergic synapse_Homo sapiens_hsa047272.42880434
8Olfactory transduction_Homo sapiens_hsa047402.34644284
9Morphine addiction_Homo sapiens_hsa050322.33751914
10Dopaminergic synapse_Homo sapiens_hsa047282.03619809
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02415173
12Salivary secretion_Homo sapiens_hsa049702.01426012
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00500529
14Amphetamine addiction_Homo sapiens_hsa050311.98422470
15Cholinergic synapse_Homo sapiens_hsa047251.94056693
16Protein export_Homo sapiens_hsa030601.90085490
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89996694
18Parkinsons disease_Homo sapiens_hsa050121.88341992
19Serotonergic synapse_Homo sapiens_hsa047261.84671489
20Taste transduction_Homo sapiens_hsa047421.83448164
21Long-term depression_Homo sapiens_hsa047301.82641597
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80625883
23Butanoate metabolism_Homo sapiens_hsa006501.79429570
24* Axon guidance_Homo sapiens_hsa043601.77619658
25Gastric acid secretion_Homo sapiens_hsa049711.76728227
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.71949620
27Insulin secretion_Homo sapiens_hsa049111.65429939
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57780689
29Linoleic acid metabolism_Homo sapiens_hsa005911.56771627
30Oxytocin signaling pathway_Homo sapiens_hsa049211.52812148
31Renin secretion_Homo sapiens_hsa049241.51610879
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50323632
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47072605
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47007813
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44555990
36Selenocompound metabolism_Homo sapiens_hsa004501.44275683
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.43875254
38GnRH signaling pathway_Homo sapiens_hsa049121.43431303
39Calcium signaling pathway_Homo sapiens_hsa040201.40159379
40Nitrogen metabolism_Homo sapiens_hsa009101.38132934
41Collecting duct acid secretion_Homo sapiens_hsa049661.35129392
42Cocaine addiction_Homo sapiens_hsa050301.34014108
43Gap junction_Homo sapiens_hsa045401.33063965
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30035047
45Tryptophan metabolism_Homo sapiens_hsa003801.27033279
46Huntingtons disease_Homo sapiens_hsa050161.26295285
47ErbB signaling pathway_Homo sapiens_hsa040121.23719316
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21173660
49cAMP signaling pathway_Homo sapiens_hsa040241.16347723
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14624086
51Estrogen signaling pathway_Homo sapiens_hsa049151.13871918
52RNA polymerase_Homo sapiens_hsa030201.13776917
53Basal transcription factors_Homo sapiens_hsa030221.12977118
54Basal cell carcinoma_Homo sapiens_hsa052171.12781006
55Regulation of autophagy_Homo sapiens_hsa041401.11220638
56Type II diabetes mellitus_Homo sapiens_hsa049301.10709658
57Hedgehog signaling pathway_Homo sapiens_hsa043401.10476554
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08212768
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06577842
60Glioma_Homo sapiens_hsa052141.05893134
61Phospholipase D signaling pathway_Homo sapiens_hsa040721.04011176
62Dorso-ventral axis formation_Homo sapiens_hsa043201.03708576
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98748058
64Melanogenesis_Homo sapiens_hsa049160.95253446
65Vibrio cholerae infection_Homo sapiens_hsa051100.94153303
66Cardiac muscle contraction_Homo sapiens_hsa042600.92653569
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90671402
68Choline metabolism in cancer_Homo sapiens_hsa052310.90079183
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.89133228
70Vitamin B6 metabolism_Homo sapiens_hsa007500.88493258
71MAPK signaling pathway_Homo sapiens_hsa040100.86144821
72Renal cell carcinoma_Homo sapiens_hsa052110.85852007
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85183118
74Circadian rhythm_Homo sapiens_hsa047100.85162958
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84943107
76Fanconi anemia pathway_Homo sapiens_hsa034600.83674817
77Hippo signaling pathway_Homo sapiens_hsa043900.83409325
78VEGF signaling pathway_Homo sapiens_hsa043700.81861686
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81507287
80Pancreatic secretion_Homo sapiens_hsa049720.81311557
81Ras signaling pathway_Homo sapiens_hsa040140.80930400
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78469697
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.76741533
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76596992
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.75832696
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75324590
87Propanoate metabolism_Homo sapiens_hsa006400.74596281
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74344214
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74113157
90Endocytosis_Homo sapiens_hsa041440.74061601
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73945845
92Oocyte meiosis_Homo sapiens_hsa041140.72001758
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69829273
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69759981
95RNA degradation_Homo sapiens_hsa030180.68932575
96ABC transporters_Homo sapiens_hsa020100.67524650
97Thyroid hormone synthesis_Homo sapiens_hsa049180.66741567
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65171624
99Rap1 signaling pathway_Homo sapiens_hsa040150.63758279
100Alzheimers disease_Homo sapiens_hsa050100.60527110
101T cell receptor signaling pathway_Homo sapiens_hsa046600.59361660
102Peroxisome_Homo sapiens_hsa041460.59329411
103Dilated cardiomyopathy_Homo sapiens_hsa054140.58484746
104Phototransduction_Homo sapiens_hsa047440.58256770
105Inositol phosphate metabolism_Homo sapiens_hsa005620.54501394
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53447941
107Endometrial cancer_Homo sapiens_hsa052130.52555293
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52266838
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52168202
110Ether lipid metabolism_Homo sapiens_hsa005650.51327417
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50507155
112Wnt signaling pathway_Homo sapiens_hsa043100.49884776
113Sulfur relay system_Homo sapiens_hsa041220.49845177
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49607854
115Metabolic pathways_Homo sapiens_hsa011000.49442887
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49410925
117Chemokine signaling pathway_Homo sapiens_hsa040620.49260577
118Homologous recombination_Homo sapiens_hsa034400.48944227
119N-Glycan biosynthesis_Homo sapiens_hsa005100.47199838
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45706663
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45294315
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45028472
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44445123
124Steroid biosynthesis_Homo sapiens_hsa001000.44404560
125Ovarian steroidogenesis_Homo sapiens_hsa049130.43234044
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43162608
127Fatty acid biosynthesis_Homo sapiens_hsa000610.42185467
128Rheumatoid arthritis_Homo sapiens_hsa053230.41568991
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41214033
130Alcoholism_Homo sapiens_hsa050340.40954534
131Oxidative phosphorylation_Homo sapiens_hsa001900.40738095
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.39573393
133Non-small cell lung cancer_Homo sapiens_hsa052230.39415807
134Colorectal cancer_Homo sapiens_hsa052100.38994833
135Glycerolipid metabolism_Homo sapiens_hsa005610.38238101
136Ribosome_Homo sapiens_hsa030100.37951498
137Tight junction_Homo sapiens_hsa045300.37720242
138mTOR signaling pathway_Homo sapiens_hsa041500.37547238
139beta-Alanine metabolism_Homo sapiens_hsa004100.35313527
140Prion diseases_Homo sapiens_hsa050200.34568479
141Fat digestion and absorption_Homo sapiens_hsa049750.34101041
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33567583
143Mineral absorption_Homo sapiens_hsa049780.33539133
144Salmonella infection_Homo sapiens_hsa051320.32700358
145Fatty acid elongation_Homo sapiens_hsa000620.32375505
146Insulin signaling pathway_Homo sapiens_hsa049100.32250123

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