SEMA4G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.47475870
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.47475870
3L-phenylalanine metabolic process (GO:0006558)7.12926889
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.12926889
5aromatic amino acid family catabolic process (GO:0009074)6.72251472
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22718613
7tryptophan catabolic process (GO:0006569)6.17100452
8indole-containing compound catabolic process (GO:0042436)6.17100452
9indolalkylamine catabolic process (GO:0046218)6.17100452
10kynurenine metabolic process (GO:0070189)6.05863536
11tryptophan metabolic process (GO:0006568)5.76337015
12bile acid biosynthetic process (GO:0006699)5.76171884
13intestinal absorption (GO:0050892)5.63785387
14glyoxylate metabolic process (GO:0046487)5.62726961
15alpha-linolenic acid metabolic process (GO:0036109)5.61441534
16urea cycle (GO:0000050)5.53390499
17urea metabolic process (GO:0019627)5.53390499
18regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.43800193
19high-density lipoprotein particle remodeling (GO:0034375)5.38463089
20negative regulation of fibrinolysis (GO:0051918)5.30893966
21sulfur amino acid catabolic process (GO:0000098)5.30654468
22cysteine metabolic process (GO:0006534)5.22517200
23protein-lipid complex subunit organization (GO:0071825)5.18667588
24protein carboxylation (GO:0018214)5.16729553
25peptidyl-glutamic acid carboxylation (GO:0017187)5.16729553
26regulation of fibrinolysis (GO:0051917)5.15822428
27regulation of protein activation cascade (GO:2000257)5.12880054
28nitrogen cycle metabolic process (GO:0071941)5.07935488
29complement activation, alternative pathway (GO:0006957)5.04982820
30bile acid metabolic process (GO:0008206)5.01221431
31serine family amino acid catabolic process (GO:0009071)4.93110305
32aromatic amino acid family metabolic process (GO:0009072)4.85996548
33regulation of apoptotic cell clearance (GO:2000425)4.78068667
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.77962753
35regulation of complement activation (GO:0030449)4.77543354
36regulation of cholesterol esterification (GO:0010872)4.76494287
37reverse cholesterol transport (GO:0043691)4.72220150
38homocysteine metabolic process (GO:0050667)4.72007749
39regulation of triglyceride catabolic process (GO:0010896)4.69791405
40negative regulation of cholesterol transport (GO:0032375)4.66809775
41negative regulation of sterol transport (GO:0032372)4.66809775
42tyrosine metabolic process (GO:0006570)4.64689836
43regulation of plasminogen activation (GO:0010755)4.62256184
44plasma lipoprotein particle remodeling (GO:0034369)4.61104860
45protein-lipid complex remodeling (GO:0034368)4.61104860
46macromolecular complex remodeling (GO:0034367)4.61104860
47triglyceride homeostasis (GO:0070328)4.58661523
48acylglycerol homeostasis (GO:0055090)4.58661523
49phospholipid efflux (GO:0033700)4.54342564
50alpha-amino acid catabolic process (GO:1901606)4.53198059
51cellular ketone body metabolic process (GO:0046950)4.52893675
52bile acid and bile salt transport (GO:0015721)4.52405085
53lysine catabolic process (GO:0006554)4.50875863
54lysine metabolic process (GO:0006553)4.50875863
55diacylglycerol metabolic process (GO:0046339)4.49010115
56amino-acid betaine metabolic process (GO:0006577)4.42970694
57coenzyme catabolic process (GO:0009109)4.41005287
58glutamate metabolic process (GO:0006536)4.39229525
59indolalkylamine metabolic process (GO:0006586)4.35039161
60drug catabolic process (GO:0042737)4.31829504
61imidazole-containing compound metabolic process (GO:0052803)4.31638550
62proline metabolic process (GO:0006560)4.30031812
63epoxygenase P450 pathway (GO:0019373)4.23103523
64cellular biogenic amine catabolic process (GO:0042402)4.23068521
65amine catabolic process (GO:0009310)4.23068521
66cellular glucuronidation (GO:0052695)4.21824868
67cholesterol efflux (GO:0033344)4.21431802
68cellular amino acid catabolic process (GO:0009063)4.19395315
69lipoprotein metabolic process (GO:0042157)4.15569324
70plasma lipoprotein particle clearance (GO:0034381)4.13898966
71cellular modified amino acid catabolic process (GO:0042219)4.13363883
72benzene-containing compound metabolic process (GO:0042537)4.12901542
73regulation of cholesterol homeostasis (GO:2000188)4.09822651
74regulation of bile acid biosynthetic process (GO:0070857)4.09161081
75glycine metabolic process (GO:0006544)4.07786407
76ethanol oxidation (GO:0006069)4.04022363
77regulation of cholesterol biosynthetic process (GO:0045540)4.03091744
78dicarboxylic acid biosynthetic process (GO:0043650)4.02981737
79plasma lipoprotein particle assembly (GO:0034377)3.97889766
80serine family amino acid metabolic process (GO:0009069)3.95459924
81arginine metabolic process (GO:0006525)3.93938532
82ketone body metabolic process (GO:1902224)3.91525224
83renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.85318324
84fibrinolysis (GO:0042730)3.79473435
85positive regulation of fatty acid biosynthetic process (GO:0045723)3.79270019
86intestinal cholesterol absorption (GO:0030299)3.77010845
87low-density lipoprotein particle remodeling (GO:0034374)3.76824991
88serine family amino acid biosynthetic process (GO:0009070)3.76387705
89very-low-density lipoprotein particle assembly (GO:0034379)3.75686903
90phospholipid homeostasis (GO:0055091)3.75331684
91cholesterol homeostasis (GO:0042632)3.74058490
92negative regulation of blood coagulation (GO:0030195)3.73932194
93negative regulation of hemostasis (GO:1900047)3.73932194
94uronic acid metabolic process (GO:0006063)3.73649433
95glucuronate metabolic process (GO:0019585)3.73649433
96negative regulation of protein activation cascade (GO:2000258)3.71024048
97positive regulation of triglyceride lipase activity (GO:0061365)3.69971320
98positive regulation of lipoprotein lipase activity (GO:0051006)3.69971320
99short-chain fatty acid metabolic process (GO:0046459)3.68919764
100sterol homeostasis (GO:0055092)3.68578252
101exogenous drug catabolic process (GO:0042738)3.67644063
102acetyl-CoA metabolic process (GO:0006084)3.66653452
103positive regulation of lipid catabolic process (GO:0050996)3.65133655
104organic acid catabolic process (GO:0016054)3.63560183
105carboxylic acid catabolic process (GO:0046395)3.63560183
106complement activation, classical pathway (GO:0006958)3.63139797
107flavonoid metabolic process (GO:0009812)3.62369535
108cofactor catabolic process (GO:0051187)3.62093849
109negative regulation of lipase activity (GO:0060192)3.62081359
110aldehyde catabolic process (GO:0046185)3.61509244
111regulation of cholesterol metabolic process (GO:0090181)3.58635694
112protein-lipid complex assembly (GO:0065005)3.58377998
113positive regulation of steroid metabolic process (GO:0045940)3.57577826
114sterol transport (GO:0015918)3.57352731
115cholesterol transport (GO:0030301)3.57352731
116complement activation (GO:0006956)3.55483493
117blood coagulation, intrinsic pathway (GO:0007597)3.54957335
118acute-phase response (GO:0006953)3.53732832
119plasma lipoprotein particle organization (GO:0071827)3.53034425
120protein activation cascade (GO:0072376)3.52777096
121ethanol metabolic process (GO:0006067)3.51733470
122negative regulation of coagulation (GO:0050819)3.46872142
123angiotensin maturation (GO:0002003)3.45612722
124positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.40381008
125proline biosynthetic process (GO:0006561)3.31150728
126lipoprotein transport (GO:0042953)3.31019822
127fat-soluble vitamin biosynthetic process (GO:0042362)3.27709015
128negative regulation of wound healing (GO:0061045)3.26719537
129regulation of humoral immune response (GO:0002920)3.25282384
130lipid homeostasis (GO:0055088)3.24505947
131lung epithelium development (GO:0060428)3.23846837
132positive regulation of blood coagulation (GO:0030194)3.23453391
133positive regulation of hemostasis (GO:1900048)3.23453391
134positive regulation of extracellular matrix organization (GO:1903055)3.22779870
135embryonic retina morphogenesis in camera-type eye (GO:0060059)3.21429471
136glutamine family amino acid biosynthetic process (GO:0009084)3.17411050
137drug transmembrane transport (GO:0006855)3.09655168
138vitamin transmembrane transport (GO:0035461)3.09303292
139regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.07117406
140positive regulation of coagulation (GO:0050820)2.99555269
141regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.98955056
142endocrine process (GO:0050886)2.98955056
143regulation of systemic arterial blood pressure by hormone (GO:0001990)2.98955056
144regulation of extracellular matrix organization (GO:1903053)2.98397130

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.92134280
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.81551231
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.29741650
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.20625384
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.08273189
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.42251935
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.32971984
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98483544
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.41596317
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.92896908
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.74517829
12* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0954117
13* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.94160220
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86353606
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82504264
16* FOXA2_19822575_ChIP-Seq_HepG2_Human1.69432267
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55898832
18TCF4_18268006_ChIP-ChIP_LS174T_Human1.51062607
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.48769015
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48447309
21HTT_18923047_ChIP-ChIP_STHdh_Human1.46216869
22* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42435554
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42223573
24CLOCK_20551151_ChIP-Seq_293T_Human1.40690858
25AR_21909140_ChIP-Seq_LNCAP_Human1.27338141
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19635447
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17576527
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16902892
29* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14678198
30GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.14506359
31NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13236088
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11248239
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08320916
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07093282
35RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06606163
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03727092
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03296256
38CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02081506
39GATA1_22025678_ChIP-Seq_K562_Human1.01931934
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01507576
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01068655
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00942100
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99635490
44CDX2_20551321_ChIP-Seq_CACO-2_Human0.99067935
45* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98771926
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98071466
47RUNX1_27514584_Chip-Seq_MCF-7_Human0.97916751
48SMC4_20622854_ChIP-Seq_HELA_Human0.96716698
49ESR2_21235772_ChIP-Seq_MCF-7_Human0.96542912
50POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96390680
51* KDM2B_26808549_Chip-Seq_K562_Human0.96378946
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96254877
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95862270
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94928229
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94892604
56* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94231887
57JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93730601
58TET1_21451524_ChIP-Seq_MESCs_Mouse0.93524808
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93426671
60GATA4_25053715_ChIP-Seq_YYC3_Human0.91528694
61TP53_22127205_ChIP-Seq_IMR90_Human0.89453369
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89006808
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88875570
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88061932
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85931688
66ZNF263_19887448_ChIP-Seq_K562_Human0.85818063
67* P68_20966046_ChIP-Seq_HELA_Human0.85013457
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84860999
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84436236
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84253539
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83688931
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83273389
73* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82261164
74ERG_21242973_ChIP-ChIP_JURKAT_Human0.82013305
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79059050
76RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78041907
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78026640
78AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77224044
79LXR_22292898_ChIP-Seq_THP-1_Human0.76299169
80NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.74948236
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74689006
82P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73047376
83RARA_24833708_ChIP-Seq_LIVER_Mouse0.72227217
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.70326978
85ATF3_27146783_Chip-Seq_COLON_Human0.70298750
86* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69996431
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69119841
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69077657
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67665629
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.67580481
91NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66203167
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66203167
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65311007
94KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65287652
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64319329
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.63061229
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.62332059
98MYC_19915707_ChIP-ChIP_AK7_Human0.57489790
99BCAT_22108803_ChIP-Seq_LS180_Human0.57480318
100* RARB_24833708_ChIP-Seq_LIVER_Mouse0.57363494
101TAF15_26573619_Chip-Seq_HEK293_Human0.56860683
102FOXA1_25552417_ChIP-Seq_VCAP_Human0.56778048
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56181252
104* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.56153516
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55388112
106EGR1_19032775_ChIP-ChIP_M12_Human0.54295946
107CTCF_27219007_Chip-Seq_Bcells_Human0.53069899
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.52401454
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52184992
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.51694929
111* GATA6_25053715_ChIP-Seq_YYC3_Human0.50794775
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.50784241
113PPAR_26484153_Chip-Seq_NCI-H1993_Human0.50625890
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.49991455
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49623801
116CEBPB_22108803_ChIP-Seq_LS180_Human0.49424655
117CREB1_26743006_Chip-Seq_LNCaP_Human0.48330461
118MYC_27129775_Chip-Seq_CORNEA_Mouse0.47781735
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.47629891
120ESET_19884257_ChIP-Seq_ESCs_Mouse0.47123017
121P53_21459846_ChIP-Seq_SAOS-2_Human0.47053741
122* SOX2_20726797_ChIP-Seq_SW620_Human0.45794746
123STAT1_17558387_ChIP-Seq_HELA_Human0.45497054
124FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45489343
125GATA2_19941826_ChIP-Seq_K562_Human0.45445961
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.44844284
127GATA1_19941826_ChIP-Seq_K562_Human0.44712981
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.44650707
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44275197
130* CBP_21632823_ChIP-Seq_H3396_Human0.44234465
131DROSHA_22980978_ChIP-Seq_HELA_Human0.44207272
132TAF2_19829295_ChIP-Seq_ESCs_Human0.44002614
133RACK7_27058665_Chip-Seq_MCF-7_Human0.42576812
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.42076644
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.41899045
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.41818526
137SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41600215
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40818048
139STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40281286
140NCOR_22424771_ChIP-Seq_293T_Human0.39547624
141SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.39144491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.31485380
2MP0005360_urolithiasis7.81364692
3MP0005085_abnormal_gallbladder_physiolo6.49182507
4MP0005365_abnormal_bile_salt6.10868995
5MP0008875_abnormal_xenobiotic_pharmacok5.18345253
6MP0003252_abnormal_bile_duct4.05582619
7MP0003806_abnormal_nucleotide_metabolis3.92597122
8MP0003122_maternal_imprinting3.91276854
9MP0010329_abnormal_lipoprotein_level3.62565596
10MP0000566_synostosis3.17943460
11MP0009840_abnormal_foam_cell3.16798906
12MP0005083_abnormal_biliary_tract3.05731437
13MP0001666_abnormal_nutrient_absorption2.90913322
14MP0003195_calcinosis2.72051056
15MP0005332_abnormal_amino_acid2.71825459
16MP0004019_abnormal_vitamin_homeostasis2.22214203
17MP0003191_abnormal_cellular_cholesterol2.20003448
18MP0002089_abnormal_postnatal_growth/wei2.12855201
19MP0002118_abnormal_lipid_homeostasis2.11461262
20MP0000609_abnormal_liver_physiology2.08747216
21MP0003123_paternal_imprinting2.07458967
22MP0005409_darkened_coat_color1.99646643
23MP0003868_abnormal_feces_composition1.95069505
24MP0003183_abnormal_peptide_metabolism1.81812967
25MP0002138_abnormal_hepatobiliary_system1.76233469
26MP0005319_abnormal_enzyme/_coenzyme1.73558637
27MP0003172_abnormal_lysosome_physiology1.54341761
28MP0005584_abnormal_enzyme/coenzyme_acti1.51956579
29MP0001764_abnormal_homeostasis1.48433084
30MP0005058_abnormal_lysosome_morphology1.47911459
31MP0005451_abnormal_body_composition1.35973774
32MP0003705_abnormal_hypodermis_morpholog1.35263842
33MP0009780_abnormal_chondrocyte_physiolo1.33286754
34MP0009697_abnormal_copulation1.32480134
35MP0003879_abnormal_hair_cell1.28514769
36MP0005257_abnormal_intraocular_pressure1.28082321
37MP0002132_abnormal_respiratory_system1.26189911
38MP0003011_delayed_dark_adaptation1.24826300
39MP0009643_abnormal_urine_homeostasis1.21336095
40MP0001915_intracranial_hemorrhage1.16397993
41MP0000604_amyloidosis1.12781543
42MP0005647_abnormal_sex_gland1.09638440
43MP0003656_abnormal_erythrocyte_physiolo1.09218881
44MP0002254_reproductive_system_inflammat1.06438927
45MP0000598_abnormal_liver_morphology1.04913591
46MP0004272_abnormal_basement_membrane0.99631254
47MP0003315_abnormal_perineum_morphology0.98423399
48MP0005636_abnormal_mineral_homeostasis0.95725124
49MP0005076_abnormal_cell_differentiation0.94213340
50MP0009764_decreased_sensitivity_to0.94193956
51MP0000678_abnormal_parathyroid_gland0.93353992
52MP0003121_genomic_imprinting0.92470192
53MP0004270_analgesia0.90836459
54MP0002822_catalepsy0.87877046
55MP0003567_abnormal_fetal_cardiomyocyte0.87437409
56MP0010368_abnormal_lymphatic_system0.87196907
57MP0003329_amyloid_beta_deposits0.85921643
58MP0009763_increased_sensitivity_to0.84675746
59MP0005084_abnormal_gallbladder_morpholo0.84477399
60MP0003186_abnormal_redox_activity0.84042855
61MP0009642_abnormal_blood_homeostasis0.84017956
62MP0003115_abnormal_respiratory_system0.81792982
63MP0002249_abnormal_larynx_morphology0.80622356
64MP0009053_abnormal_anal_canal0.79804370
65MP0002876_abnormal_thyroid_physiology0.79759342
66MP0002078_abnormal_glucose_homeostasis0.76521208
67MP0003690_abnormal_glial_cell0.72345651
68MP0003942_abnormal_urinary_system0.72113106
69MP0005408_hypopigmentation0.71987075
70MP0009765_abnormal_xenobiotic_induced0.71406295
71MP0005376_homeostasis/metabolism_phenot0.70623424
72MP0008469_abnormal_protein_level0.70054314
73MP0005220_abnormal_exocrine_pancreas0.68512619
74MP0002971_abnormal_brown_adipose0.68483793
75MP0005535_abnormal_body_temperature0.68301264
76MP0004858_abnormal_nervous_system0.68147146
77MP0002909_abnormal_adrenal_gland0.68090901
78MP0000477_abnormal_intestine_morphology0.67713312
79MP0001664_abnormal_digestion0.67706093
80MP0005334_abnormal_fat_pad0.66355218
81MP0005448_abnormal_energy_balance0.65177473
82MP0001756_abnormal_urination0.63400353
83MP0001270_distended_abdomen0.63130959
84MP0006036_abnormal_mitochondrial_physio0.62778982
85MP0010234_abnormal_vibrissa_follicle0.62766073
86MP0004130_abnormal_muscle_cell0.62042451
87MP0005266_abnormal_metabolism0.59666319
88MP0000639_abnormal_adrenal_gland0.59041364
89MP0000534_abnormal_ureter_morphology0.58205610
90MP0003878_abnormal_ear_physiology0.57605145
91MP0005377_hearing/vestibular/ear_phenot0.57605145
92MP0005670_abnormal_white_adipose0.57595697
93MP0003866_abnormal_defecation0.56058813
94MP0001661_extended_life_span0.54329406
95MP0005248_abnormal_Harderian_gland0.54176758
96MP0006035_abnormal_mitochondrial_morpho0.53776559
97MP0000579_abnormal_nail_morphology0.52755952
98MP0000003_abnormal_adipose_tissue0.52289923
99MP0002938_white_spotting0.52259691
100MP0008872_abnormal_physiological_respon0.51889377
101MP0004264_abnormal_extraembryonic_tissu0.51451661
102MP0003943_abnormal_hepatobiliary_system0.50730413
103MP0008874_decreased_physiological_sensi0.49278468
104MP0003638_abnormal_response/metabolism_0.48443076
105MP0002896_abnormal_bone_mineralization0.47950258
106MP0002928_abnormal_bile_duct0.46651252
107MP0009384_cardiac_valve_regurgitation0.46205341
108MP0003953_abnormal_hormone_level0.45709229
109MP0003632_abnormal_nervous_system0.45226452
110MP0006054_spinal_hemorrhage0.44730237
111MP0005187_abnormal_penis_morphology0.44653636
112MP0002136_abnormal_kidney_physiology0.43865260
113MP0005166_decreased_susceptibility_to0.43760399
114MP0002796_impaired_skin_barrier0.42661898
115MP0003566_abnormal_cell_adhesion0.41756876
116MP0002233_abnormal_nose_morphology0.41524617
117MP0005395_other_phenotype0.40520629
118MP0003941_abnormal_skin_development0.39322778
119MP0001849_ear_inflammation0.39035588
120MP0002092_abnormal_eye_morphology0.38984217
121MP0003119_abnormal_digestive_system0.37777218
122MP0004782_abnormal_surfactant_physiolog0.37350359
123MP0003075_altered_response_to0.36704323
124MP0008873_increased_physiological_sensi0.36650761
125MP0003718_maternal_effect0.36250407
126MP0009672_abnormal_birth_weight0.35399487
127MP0002697_abnormal_eye_size0.34997116
128MP0000920_abnormal_myelination0.34973963
129MP0005167_abnormal_blood-brain_barrier0.34814085
130MP0000538_abnormal_urinary_bladder0.34589884
131MP0004043_abnormal_pH_regulation0.34462736
132MP0005464_abnormal_platelet_physiology0.34294651
133MP0000230_abnormal_systemic_arterial0.33321403
134MP0001765_abnormal_ion_homeostasis0.29131724
135MP0002090_abnormal_vision0.28314493
136MP0002837_dystrophic_cardiac_calcinosis0.27713876
137MP0005666_abnormal_adipose_tissue0.27038646
138MP0004381_abnormal_hair_follicle0.26944819
139MP0002168_other_aberrant_phenotype0.26402430
140MP0002069_abnormal_eating/drinking_beha0.26047509
141MP0009115_abnormal_fat_cell0.25372945
142MP0004883_abnormal_blood_vessel0.25369367
143MP0002970_abnormal_white_adipose0.24595140
144MP0000467_abnormal_esophagus_morphology0.22201418
145MP0001881_abnormal_mammary_gland0.21933254
146MP0000427_abnormal_hair_cycle0.21597824

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.32038489
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.31924053
3Deep venous thrombosis (HP:0002625)7.28088242
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.64372098
5Hypobetalipoproteinemia (HP:0003563)6.42175324
6Prolonged partial thromboplastin time (HP:0003645)6.38807740
7Xanthomatosis (HP:0000991)6.18903644
8Hyperlipoproteinemia (HP:0010980)5.39588778
9Complement deficiency (HP:0004431)5.28746271
10Hypolipoproteinemia (HP:0010981)4.73670249
11Epidermoid cyst (HP:0200040)4.61623976
12Hyperammonemia (HP:0001987)4.53564686
13Joint hemorrhage (HP:0005261)4.50800259
14Hyperglycinemia (HP:0002154)4.48852827
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.33295590
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.27088608
17Abnormality of the common coagulation pathway (HP:0010990)4.25750189
18Ketosis (HP:0001946)4.25032967
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.16574603
20Fat malabsorption (HP:0002630)4.15242692
21Hypoalphalipoproteinemia (HP:0003233)4.09010485
22Conjugated hyperbilirubinemia (HP:0002908)4.05368908
23Hyperglycinuria (HP:0003108)4.00356484
24Abnormality of glycine metabolism (HP:0010895)3.99400807
25Abnormality of serine family amino acid metabolism (HP:0010894)3.99400807
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.96828651
27Abnormality of methionine metabolism (HP:0010901)3.90259464
28Abnormality of complement system (HP:0005339)3.80263843
29Hypoglycemic coma (HP:0001325)3.62998772
30Hypercholesterolemia (HP:0003124)3.60752760
31Abnormality of the intrinsic pathway (HP:0010989)3.52767114
32Abnormality of pyrimidine metabolism (HP:0004353)3.52074053
33Flat acetabular roof (HP:0003180)3.43711383
34Abnormality of carpal bone ossification (HP:0006257)3.37031682
35Hyperbilirubinemia (HP:0002904)3.32722247
36Abnormal tarsal ossification (HP:0008369)3.23242652
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.18531609
38Delayed CNS myelination (HP:0002188)3.11748208
39Abnormality of fatty-acid metabolism (HP:0004359)3.11304179
40Spontaneous abortion (HP:0005268)3.09014937
41Ketoacidosis (HP:0001993)3.07200505
42Abnormality of nucleobase metabolism (HP:0010932)3.00095400
43Steatorrhea (HP:0002570)2.96642164
44Hypochromic microcytic anemia (HP:0004840)2.95792723
45Hepatocellular carcinoma (HP:0001402)2.95098952
46Myocardial infarction (HP:0001658)2.90081813
47Abnormality of serum amino acid levels (HP:0003112)2.86123857
48Skin nodule (HP:0200036)2.74956565
49Metabolic acidosis (HP:0001942)2.74135152
50Abnormality of purine metabolism (HP:0004352)2.74106073
51Broad alveolar ridges (HP:0000187)2.68927456
52Acanthocytosis (HP:0001927)2.68518576
53Vascular calcification (HP:0004934)2.68127965
54Malnutrition (HP:0004395)2.66936736
55Systemic lupus erythematosus (HP:0002725)2.66221461
56Widely patent fontanelles and sutures (HP:0004492)2.64199744
57Gout (HP:0001997)2.61348137
58Abnormal ossification of hand bones (HP:0005921)2.55281065
59Abnormal hand bone ossification (HP:0010660)2.53947811
60Nephritis (HP:0000123)2.53726741
61Abnormal gallbladder morphology (HP:0012437)2.52465067
62Abnormal gallbladder physiology (HP:0012438)2.49498151
63Cholecystitis (HP:0001082)2.49498151
64Asymmetry of the thorax (HP:0001555)2.48305175
65Cholelithiasis (HP:0001081)2.47838563
66Hypoglycemic seizures (HP:0002173)2.46363466
67Facial shape deformation (HP:0011334)2.44747447
68Potter facies (HP:0002009)2.44747447
69Purpura (HP:0000979)2.44400259
70Small epiphyses (HP:0010585)2.43416915
71Lethargy (HP:0001254)2.42101038
72Mitral stenosis (HP:0001718)2.39159399
73Spastic diplegia (HP:0001264)2.38818623
74Neonatal onset (HP:0003623)2.38787284
75Irritability (HP:0000737)2.38592186
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37939185
77Dicarboxylic aciduria (HP:0003215)2.37939185
78Glomerulonephritis (HP:0000099)2.35222851
79Cardiovascular calcification (HP:0011915)2.35081084
80Broad palm (HP:0001169)2.34650855
81Vaginal fistula (HP:0004320)2.32309203
82Amyloidosis (HP:0011034)2.31800709
83Sensorimotor neuropathy (HP:0007141)2.28889994
84Pigmentary retinal degeneration (HP:0001146)2.28619000
85Hepatoblastoma (HP:0002884)2.28205650
86Neonatal short-limb short stature (HP:0008921)2.22776990
87Late onset (HP:0003584)2.21007920
88Abnormality of the nasal septum (HP:0000419)2.18151678
89Abnormality of the lumbar spine (HP:0100712)2.17680302
90Osteomalacia (HP:0002749)2.14317077
91Poikilocytosis (HP:0004447)2.12679444
92Esophageal varix (HP:0002040)2.11696698
93Enlarged kidneys (HP:0000105)2.10899792
94Abnormality of the gallbladder (HP:0005264)2.10663419
95Hemorrhage of the eye (HP:0011885)2.10184694
96Rickets (HP:0002748)2.09732059
97Wide cranial sutures (HP:0010537)2.07321156
98Increased serum pyruvate (HP:0003542)2.06776529
99Brushfield spots (HP:0001088)2.05882288
100Cerebral edema (HP:0002181)2.05360832
101Hypophosphatemic rickets (HP:0004912)2.05227180
102Pancreatitis (HP:0001733)2.04410377
103Alacrima (HP:0000522)2.03317683
104Gingival bleeding (HP:0000225)2.02491988
105Alkalosis (HP:0001948)2.02324833
106Vomiting (HP:0002013)2.00617454
107Abnormality of glycolysis (HP:0004366)2.00127317
108Hydroxyprolinuria (HP:0003080)2.00062561
109Abnormality of proline metabolism (HP:0010907)2.00062561
110Status epilepticus (HP:0002133)1.99871353
111Bronchomalacia (HP:0002780)1.99310634
112Abnormal foot bone ossification (HP:0010675)1.95912227
113Bifid scrotum (HP:0000048)1.94995848
114Opisthotonus (HP:0002179)1.94540028
115Hyperinsulinemic hypoglycemia (HP:0000825)1.94099243
116Menorrhagia (HP:0000132)1.93477110
117Recurrent gram-negative bacterial infections (HP:0005420)1.93470122
118Thrombophlebitis (HP:0004418)1.92127925
119Protrusio acetabuli (HP:0003179)1.92037419
120Focal segmental glomerulosclerosis (HP:0000097)1.91359867
121Epiphyseal dysplasia (HP:0002656)1.89425387
122Glomerulosclerosis (HP:0000096)1.88497708
123Flared iliac wings (HP:0002869)1.86078341
124Arthropathy (HP:0003040)1.85490385
125Abnormal cartilage morphology (HP:0002763)1.85098023
126Hypotension (HP:0002615)1.84976953
127Abnormality of vitamin metabolism (HP:0100508)1.80859729
128Abnormality of the Achilles tendon (HP:0005109)1.80462552
129Neonatal death (HP:0003811)1.80385319
130Abnormality of the acetabulum (HP:0003170)1.80318496
131Reticulocytosis (HP:0001923)1.79645058
132Ileus (HP:0002595)1.79499435
133Abnormal enzyme/coenzyme activity (HP:0012379)1.79096669
134Proximal tubulopathy (HP:0000114)1.76592024
135Pancreatic islet-cell hyperplasia (HP:0004510)1.76205316
136Abnormality of transition element cation homeostasis (HP:0011030)1.76086781
137Generalized aminoaciduria (HP:0002909)1.75254786
138Symptomatic seizures (HP:0011145)1.74249295
139Increased purine levels (HP:0004368)1.74197456
140Hyperuricemia (HP:0002149)1.74197456
141Abnormality of iron homeostasis (HP:0011031)1.72698039
142Cupped ribs (HP:0000887)1.69100137
143Impaired pain sensation (HP:0007328)1.68315707
144Abnormality of pain sensation (HP:0010832)1.68315707
145Irregular epiphyses (HP:0010582)1.66553013
146Abnormality of the vitreous humor (HP:0004327)1.65802018
147Hypophosphatemia (HP:0002148)1.60786911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.73288595
2SIK14.32536180
3FGFR44.31548854
4ERN14.18435317
5EPHA23.26921470
6WNK43.08340678
7ERBB42.89715014
8CDK122.78069296
9TAOK32.72903418
10INSRR2.70939626
11MST1R2.69818869
12MAP2K42.56319562
13PIK3CA2.31530992
14TYRO32.26494593
15PKN22.02982020
16DAPK21.95026234
17PTK61.86340479
18FRK1.73916453
19MAPK111.73867012
20DDR21.72678903
21FGFR11.67122786
22EEF2K1.62313815
23LATS11.60528793
24TRIB31.55783236
25FGFR21.48248772
26ERBB21.45205004
27WNK11.44579958
28MAP3K71.42823680
29ICK1.38995332
30PIK3CG1.38231399
31RIPK11.37142502
32AKT31.34201281
33MARK11.33444549
34STK391.28729351
35PRKCZ1.17917858
36GRK61.17379546
37PRKAA21.14260815
38MAP3K101.14217476
39EPHB21.12654136
40TYK21.08320721
41ABL21.07848782
42FLT31.06001876
43JAK21.05720464
44MAPK151.04690424
45PRKG21.02862820
46CDC42BPA0.96447946
47ACVR1B0.95031012
48EPHA40.93971740
49MET0.90284413
50SMG10.89864233
51EPHB10.87797068
52MAP2K60.87343985
53PRKAA10.86599323
54MAPK40.86340863
55PINK10.86025625
56PTK20.85435011
57IRAK30.84724166
58FGR0.81492161
59DYRK1B0.80873737
60PRKACG0.80280751
61SGK30.79817401
62CAMK1D0.79553144
63CAMK2G0.79263134
64MAPK120.77996105
65MAP3K40.73884630
66CAMK1G0.70920694
67GSK3A0.70423416
68JAK10.67837031
69CSNK1G20.67455519
70RET0.67247405
71PKN10.66512234
72CDK70.66446643
73LATS20.66312468
74TBK10.66089235
75MATK0.65753763
76CSNK1G10.63280825
77PDPK10.63235424
78PAK30.62383954
79NTRK30.61357052
80EPHA30.61333814
81NEK90.61187242
82SGK4940.59049890
83SGK2230.59049890
84NEK20.58581692
85PRKCG0.57845973
86SGK20.57713037
87KSR20.57369019
88CDK60.57243040
89MAP3K20.56642200
90KDR0.56140742
91STK38L0.55186265
92SGK10.55084345
93NTRK10.54729383
94SIK20.54313772
95MAP2K20.54118249
96EIF2AK10.53868346
97RPS6KB10.53375685
98BRD40.53021553
99MAP2K10.52741079
100MARK20.52576308
101CSNK1G30.48953989
102CSK0.48847063
103CAMK40.48700261
104CSNK1E0.47962056
105CAMKK10.47872018
106MAP3K10.47813655
107CSNK1A1L0.46793376
108MAP3K110.46614143
109SRC0.45511462
110LMTK20.44646447
111FGFR30.43428031
112NTRK20.43045468
113MAPK70.42592724
114BRSK10.42376727
115MTOR0.41470932
116MAP3K90.41470488
117PHKG20.40748989
118PHKG10.40748989
119STK380.40601097
120BCR0.40599245
121GRK10.40000447
122MAP2K30.38741388
123MAP3K60.37378664
124IGF1R0.35740460
125PRKCQ0.35057298
126CSF1R0.34921852
127PDK10.34905205
128PDGFRA0.34472988
129MAP3K130.34084890
130TAOK10.33377715
131MELK0.33274267
132PRKCA0.32632172
133PDGFRB0.32590290
134MAP3K30.32438827
135FER0.32098718
136CDK80.30402436
137BMX0.29783536
138CDK90.28498128
139CDK40.24793877
140RPS6KA30.23411456
141NME10.21495207
142PDK20.21184267
143CDK150.20012689
144MAPKAPK30.19841517
145TGFBR20.19649504
146FYN0.18180357
147MAPK30.17191858
148MAPK80.16873721

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.40592347
2Nitrogen metabolism_Homo sapiens_hsa009103.62393039
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36570782
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25401220
5Arginine biosynthesis_Homo sapiens_hsa002203.04608175
6Tryptophan metabolism_Homo sapiens_hsa003802.72800792
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71564456
8Complement and coagulation cascades_Homo sapiens_hsa046102.62579022
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59725146
10Fatty acid degradation_Homo sapiens_hsa000712.43947628
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42486582
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33086315
13Butanoate metabolism_Homo sapiens_hsa006502.27400719
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21985310
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11421857
16Peroxisome_Homo sapiens_hsa041461.99545451
17Histidine metabolism_Homo sapiens_hsa003401.98885496
18Chemical carcinogenesis_Homo sapiens_hsa052041.89843861
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.88281011
20PPAR signaling pathway_Homo sapiens_hsa033201.86732379
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86505928
22Propanoate metabolism_Homo sapiens_hsa006401.82257374
23Fatty acid metabolism_Homo sapiens_hsa012121.78153987
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74296921
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72722251
26Bile secretion_Homo sapiens_hsa049761.72696765
27beta-Alanine metabolism_Homo sapiens_hsa004101.66698493
28Retinol metabolism_Homo sapiens_hsa008301.66000307
29Caffeine metabolism_Homo sapiens_hsa002321.65977663
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.65700580
31Staphylococcus aureus infection_Homo sapiens_hsa051501.61613858
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58700408
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51373053
34Selenocompound metabolism_Homo sapiens_hsa004501.51297693
35Sulfur metabolism_Homo sapiens_hsa009201.50400800
36Phenylalanine metabolism_Homo sapiens_hsa003601.48259426
37Other glycan degradation_Homo sapiens_hsa005111.46228267
38Tyrosine metabolism_Homo sapiens_hsa003501.38534661
39Fat digestion and absorption_Homo sapiens_hsa049751.35335997
40Pyruvate metabolism_Homo sapiens_hsa006201.34334474
41Starch and sucrose metabolism_Homo sapiens_hsa005001.32775395
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30771193
43ABC transporters_Homo sapiens_hsa020101.25683126
44Steroid biosynthesis_Homo sapiens_hsa001001.24907713
45Fatty acid elongation_Homo sapiens_hsa000621.22085406
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.20199530
47Folate biosynthesis_Homo sapiens_hsa007901.16325518
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14647433
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14139558
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.12974232
51Biosynthesis of amino acids_Homo sapiens_hsa012301.10956859
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.10492875
53Carbon metabolism_Homo sapiens_hsa012001.05671823
54Arginine and proline metabolism_Homo sapiens_hsa003300.94835592
55Vitamin digestion and absorption_Homo sapiens_hsa049770.93462683
56Vitamin B6 metabolism_Homo sapiens_hsa007500.86904000
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.86111579
58Lysine degradation_Homo sapiens_hsa003100.85412019
59Sulfur relay system_Homo sapiens_hsa041220.83020520
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80765412
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79674060
62Glycerolipid metabolism_Homo sapiens_hsa005610.74403497
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69686438
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63430370
65Glutathione metabolism_Homo sapiens_hsa004800.62533937
66N-Glycan biosynthesis_Homo sapiens_hsa005100.57513664
67Fatty acid biosynthesis_Homo sapiens_hsa000610.56677302
68One carbon pool by folate_Homo sapiens_hsa006700.51757719
69Sphingolipid metabolism_Homo sapiens_hsa006000.49511141
70Pentose phosphate pathway_Homo sapiens_hsa000300.46884135
71Arachidonic acid metabolism_Homo sapiens_hsa005900.44813928
72Metabolic pathways_Homo sapiens_hsa011000.41979848
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41574227
74Galactose metabolism_Homo sapiens_hsa000520.36831723
75Prion diseases_Homo sapiens_hsa050200.36047010
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31385024
77Fructose and mannose metabolism_Homo sapiens_hsa000510.31108991
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26884974
79Pertussis_Homo sapiens_hsa051330.26835886
80Insulin resistance_Homo sapiens_hsa049310.25440806
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.23534954
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22067031
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21671366
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.20068228
85Linoleic acid metabolism_Homo sapiens_hsa005910.15949885
86Glucagon signaling pathway_Homo sapiens_hsa049220.13863566
87Ether lipid metabolism_Homo sapiens_hsa005650.11537295
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10550300
89ECM-receptor interaction_Homo sapiens_hsa045120.09173859
90AMPK signaling pathway_Homo sapiens_hsa041520.06583618
91Adherens junction_Homo sapiens_hsa045200.05280503
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.03184519
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.02610678
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.02402324
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.01430565
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1996941
97Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1967851
98Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1901244
99Regulation of autophagy_Homo sapiens_hsa04140-0.1863791
100Protein digestion and absorption_Homo sapiens_hsa04974-0.1821826
101Bladder cancer_Homo sapiens_hsa05219-0.1758462
102GABAergic synapse_Homo sapiens_hsa04727-0.1748813
103African trypanosomiasis_Homo sapiens_hsa05143-0.1553838
104Hepatitis C_Homo sapiens_hsa05160-0.1529683
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1407971
106Type II diabetes mellitus_Homo sapiens_hsa04930-0.1116172
107Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1081986
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0961147
109Renin-angiotensin system_Homo sapiens_hsa04614-0.0880381
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0766742
111Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0675083
112Insulin signaling pathway_Homo sapiens_hsa04910-0.0515477
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0322454
114Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0143986
115Mineral absorption_Homo sapiens_hsa04978-0.0049234

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