SEMA5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.11558620
2central nervous system myelination (GO:0022010)4.11558620
3lateral sprouting from an epithelium (GO:0060601)4.08789770
4locomotory exploration behavior (GO:0035641)3.92490278
5collagen fibril organization (GO:0030199)3.77689221
6sequestering of extracellular ligand from receptor (GO:0035581)3.75354058
7myelination (GO:0042552)3.70804905
8axon ensheathment (GO:0008366)3.66858536
9ensheathment of neurons (GO:0007272)3.66858536
10cell migration involved in heart development (GO:0060973)3.59791221
11positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.54298876
12chondrocyte proliferation (GO:0035988)3.40634553
13apical protein localization (GO:0045176)3.39657225
14neuron cell-cell adhesion (GO:0007158)3.36357021
15exploration behavior (GO:0035640)3.31167719
16presynaptic membrane assembly (GO:0097105)3.28710312
17myelination in peripheral nervous system (GO:0022011)3.28390576
18peripheral nervous system axon ensheathment (GO:0032292)3.28390576
19fatty acid elongation (GO:0030497)3.21611962
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.19609162
21* regulation of axon guidance (GO:1902667)3.19077146
22* neuron recognition (GO:0008038)3.18221816
23* regulation of axon extension involved in axon guidance (GO:0048841)3.17056554
24* axonal fasciculation (GO:0007413)3.14705843
25smooth muscle tissue development (GO:0048745)3.09217615
26dendritic spine morphogenesis (GO:0060997)3.08177057
27L-amino acid import (GO:0043092)3.07410239
28endocardial cushion morphogenesis (GO:0003203)3.06623824
29negative regulation of hormone biosynthetic process (GO:0032353)3.05601380
30negative regulation of neurotransmitter secretion (GO:0046929)3.04939039
31neural crest cell development (GO:0014032)3.03116077
32dendrite morphogenesis (GO:0048813)3.02245362
33regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.01367957
34cerebral cortex radially oriented cell migration (GO:0021799)3.00074545
35protein heterotrimerization (GO:0070208)2.99852966
36presynaptic membrane organization (GO:0097090)2.98554187
37asymmetric protein localization (GO:0008105)2.97781064
38central nervous system projection neuron axonogenesis (GO:0021952)2.97390314
39* negative regulation of axon guidance (GO:1902668)2.97199682
40glomerular basement membrane development (GO:0032836)2.95369356
41regulation of integrin-mediated signaling pathway (GO:2001044)2.93088719
42endodermal cell differentiation (GO:0035987)2.92221570
43mesenchymal-epithelial cell signaling (GO:0060638)2.91750683
44negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90550900
45* negative regulation of axon extension involved in axon guidance (GO:0048843)2.88194281
46mesenchymal cell development (GO:0014031)2.86832171
47negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.85600170
48head development (GO:0060322)2.85353665
49camera-type eye morphogenesis (GO:0048593)2.85274485
50negative regulation of neurotransmitter transport (GO:0051589)2.83866419
51regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.82811519
52mesenchyme morphogenesis (GO:0072132)2.82593579
53limb bud formation (GO:0060174)2.82156305
54cerebellar granule cell differentiation (GO:0021707)2.79854215
55amino acid import (GO:0043090)2.78246283
56metanephric mesenchyme development (GO:0072075)2.77719331
57neuronal ion channel clustering (GO:0045161)2.77062764
58tonic smooth muscle contraction (GO:0014820)2.76536189
59ionotropic glutamate receptor signaling pathway (GO:0035235)2.75069362
60regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.72380687
61regulation of short-term neuronal synaptic plasticity (GO:0048172)2.72331656
62kidney mesenchyme development (GO:0072074)2.70242214
63* negative regulation of axon extension (GO:0030517)2.69825994
64negative regulation of chondrocyte differentiation (GO:0032331)2.69476336
65glomerulus development (GO:0032835)2.69458637
66pericardium development (GO:0060039)2.68212918
67prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.68163864
68transmission of nerve impulse (GO:0019226)2.66877322
69cardiac myofibril assembly (GO:0055003)2.66310071
70bone trabecula formation (GO:0060346)2.65346867
71potassium ion import (GO:0010107)2.63756706
72positive regulation of neurological system process (GO:0031646)2.62085670
73regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.61074055
74negative regulation of catenin import into nucleus (GO:0035414)2.60459796
75artery development (GO:0060840)2.59750124
76peptidyl-tyrosine autophosphorylation (GO:0038083)2.58686160
77chondroitin sulfate catabolic process (GO:0030207)2.58291553
78regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.57733258
79negative regulation of hormone metabolic process (GO:0032351)2.57695464
80* negative regulation of axonogenesis (GO:0050771)2.57656879
81neuronal action potential propagation (GO:0019227)2.56350328
82dermatan sulfate biosynthetic process (GO:0030208)2.55978200
83long-chain fatty acid biosynthetic process (GO:0042759)2.55646382
84glomerular filtration (GO:0003094)2.55440718
85semaphorin-plexin signaling pathway (GO:0071526)2.55306912
86peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.55082931
87vascular endothelial growth factor signaling pathway (GO:0038084)2.54541145
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.53417741
89vascular smooth muscle contraction (GO:0014829)2.53269305
90planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51660738
91glutamate receptor signaling pathway (GO:0007215)2.51248511
92keratan sulfate catabolic process (GO:0042340)2.50798975
93renal filtration (GO:0097205)2.50734710
94endocardial cushion development (GO:0003197)2.50660054
95regulation of non-canonical Wnt signaling pathway (GO:2000050)2.50012996
96regulation of collateral sprouting (GO:0048670)2.49817327
97body morphogenesis (GO:0010171)2.45785556
98chondrocyte development (GO:0002063)2.45511701
99axon extension involved in axon guidance (GO:0048846)2.44635941
100neuron projection extension involved in neuron projection guidance (GO:1902284)2.44635941
101craniofacial suture morphogenesis (GO:0097094)2.44434848
102synaptic vesicle maturation (GO:0016188)2.44422220
103positive regulation of fibroblast migration (GO:0010763)2.44278641
104regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43840039
105negative chemotaxis (GO:0050919)2.43691395
106cranial nerve morphogenesis (GO:0021602)2.43490553
107substrate adhesion-dependent cell spreading (GO:0034446)2.43389253
108embryonic retina morphogenesis in camera-type eye (GO:0060059)2.42670580
109long-term synaptic potentiation (GO:0060291)2.42486518
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.41351829
111extracellular matrix assembly (GO:0085029)2.40166937
112central nervous system neuron axonogenesis (GO:0021955)2.39373163
113collagen metabolic process (GO:0032963)2.38722738
114regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.37991035
115regulation of type B pancreatic cell apoptotic process (GO:2000674)2.37913511
116startle response (GO:0001964)2.37819326
117cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.37295293
118regulation of glomerulus development (GO:0090192)2.36766079
119synaptic transmission, glutamatergic (GO:0035249)2.36472816
120regulation of neuronal synaptic plasticity (GO:0048168)2.36199306
121glomerular visceral epithelial cell development (GO:0072015)2.36197346
122collagen catabolic process (GO:0030574)2.36178702
123positive regulation of protein autophosphorylation (GO:0031954)2.36111932
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.33468769
125negative regulation of protein localization to cell surface (GO:2000009)2.33212880
126regulation of synaptic vesicle exocytosis (GO:2000300)2.32240781
127paraxial mesoderm development (GO:0048339)2.32086998
128enteric nervous system development (GO:0048484)2.32084892
129photoreceptor cell differentiation (GO:0046530)2.31765954
130eye photoreceptor cell differentiation (GO:0001754)2.31765954
131extracellular regulation of signal transduction (GO:1900115)2.31624324
132extracellular negative regulation of signal transduction (GO:1900116)2.31624324
133neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.30871097
134stem cell development (GO:0048864)2.30678514
135establishment of tissue polarity (GO:0007164)2.30436849
136establishment of planar polarity (GO:0001736)2.30436849
137renal tubule morphogenesis (GO:0061333)2.29802802
138cyclic nucleotide catabolic process (GO:0009214)2.29659113
139gamma-aminobutyric acid transport (GO:0015812)2.29049720
140dermatan sulfate metabolic process (GO:0030205)2.28347250
141embryonic body morphogenesis (GO:0010172)2.28192021
142multicellular organismal macromolecule metabolic process (GO:0044259)2.26707235
143neuron remodeling (GO:0016322)2.26389849
144vocalization behavior (GO:0071625)2.26243499
145cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.26175293
146extracellular fibril organization (GO:0043206)2.25579556
147negative regulation of cartilage development (GO:0061037)2.25457338
148response to methylmercury (GO:0051597)2.24667481
149axonogenesis (GO:0007409)2.24317700
150dendritic spine organization (GO:0097061)2.23813420
151lymphangiogenesis (GO:0001946)2.23740249
152basement membrane organization (GO:0071711)2.23688453
153ephrin receptor signaling pathway (GO:0048013)2.23094336
154Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.23035497
155retina vasculature morphogenesis in camera-type eye (GO:0061299)2.22716553
156multicellular organismal catabolic process (GO:0044243)2.21839185
157layer formation in cerebral cortex (GO:0021819)2.21604132
158neuron projection morphogenesis (GO:0048812)2.21440503
159blood vessel maturation (GO:0001955)2.20312149
160appendage development (GO:0048736)2.19806775
161limb development (GO:0060173)2.19806775
162fibroblast migration (GO:0010761)2.19764206
163negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.17192209
164multicellular organismal metabolic process (GO:0044236)2.17185544
165endocrine hormone secretion (GO:0060986)2.17064754
166postsynaptic membrane organization (GO:0001941)2.16338778
167adrenal gland development (GO:0030325)2.15626325
168type B pancreatic cell proliferation (GO:0044342)2.15445819
169anterior/posterior axis specification, embryo (GO:0008595)2.13836679
170myofibril assembly (GO:0030239)2.13466936
171chondroitin sulfate biosynthetic process (GO:0030206)2.12866091
172cell proliferation involved in kidney development (GO:0072111)2.12537982
173smooth muscle cell differentiation (GO:0051145)2.12052994
174negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.12026595
175regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.09751597
176activin receptor signaling pathway (GO:0032924)2.09737436
177positive regulation of macrophage activation (GO:0043032)2.08093274
178extracellular matrix disassembly (GO:0022617)2.06754640
179atrioventricular valve morphogenesis (GO:0003181)2.06399325
180extracellular matrix organization (GO:0030198)2.05557469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.66742409
2GBX2_23144817_ChIP-Seq_PC3_Human3.28330106
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77524368
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70802401
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63945104
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58518337
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58518337
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.55173329
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51786171
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.48573035
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38056490
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37201791
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35275671
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35049471
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.27708580
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26797701
17AR_21572438_ChIP-Seq_LNCaP_Human2.15943504
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13780615
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13002474
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.08335849
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00294465
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.97033286
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.93974436
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88860828
25* EZH2_27294783_Chip-Seq_ESCs_Mouse1.87096794
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86516757
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.86446539
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86009464
29DROSHA_22980978_ChIP-Seq_HELA_Human1.82894491
30TAF15_26573619_Chip-Seq_HEK293_Human1.82458603
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82313153
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81693994
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.81079623
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78225416
35CJUN_26792858_Chip-Seq_BT549_Human1.76305822
36* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76208261
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.71731066
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68664245
39* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64795296
40* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62693055
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62263442
42* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59967647
43* SMAD3_21741376_ChIP-Seq_EPCs_Human1.56455709
44* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56107560
45P300_19829295_ChIP-Seq_ESCs_Human1.53293778
46* BRD4_25478319_ChIP-Seq_HGPS_Human1.51837785
47* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51056639
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.50587002
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.46755304
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46430148
51FUS_26573619_Chip-Seq_HEK293_Human1.45167719
52* EP300_21415370_ChIP-Seq_HL-1_Mouse1.43994071
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42311151
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38768159
55ZNF274_21170338_ChIP-Seq_K562_Hela1.37730879
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37483072
57TP53_16413492_ChIP-PET_HCT116_Human1.36165525
58AHR_22903824_ChIP-Seq_MCF-7_Human1.35983824
59* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35813780
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.34436403
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.33701388
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.32564835
63BCAT_22108803_ChIP-Seq_LS180_Human1.31712564
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30505925
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30276728
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29268401
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28513051
68TP53_18474530_ChIP-ChIP_U2OS_Human1.28468172
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26846968
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25144848
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.24064776
72* SMAD3_21741376_ChIP-Seq_HESCs_Human1.23778164
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23079613
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22133241
75VDR_22108803_ChIP-Seq_LS180_Human1.21761249
76* STAT3_23295773_ChIP-Seq_U87_Human1.20486866
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.20012640
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19458338
79EWS_26573619_Chip-Seq_HEK293_Human1.19444286
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18869244
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18801331
82* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18342731
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17160478
84AR_25329375_ChIP-Seq_VCAP_Human1.16971287
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.16595511
86* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16064935
87RNF2_27304074_Chip-Seq_NSC_Mouse1.15605485
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.15504873
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15377368
90* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13548428
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13138091
92REST_21632747_ChIP-Seq_MESCs_Mouse1.12912373
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12910051
94ER_23166858_ChIP-Seq_MCF-7_Human1.10653850
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10101735
96AR_19668381_ChIP-Seq_PC3_Human1.09218591
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08805614
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08805614
99P53_22387025_ChIP-Seq_ESCs_Mouse1.08072879
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07873256
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07873256
102TCF4_18268006_ChIP-ChIP_LS174T_Human1.07761175
103KDM2B_26808549_Chip-Seq_REH_Human1.07428251
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05873765
105ISL1_27105846_Chip-Seq_CPCs_Mouse1.05470328
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05449808
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04554544
108RARB_27405468_Chip-Seq_BRAIN_Mouse1.04366212
109CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04269639
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04124252
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03431709
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03360275
113SALL1_21062744_ChIP-ChIP_HESCs_Human1.02888927
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02819214
115* RUNX2_22187159_ChIP-Seq_PCA_Human1.02587557
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01894289
117* TCF4_23295773_ChIP-Seq_U87_Human1.01291364
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01211744
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00793816
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99644158
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99177534
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98930271
123* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98654557
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.98451478
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98217031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.28318078
2MP0003880_abnormal_central_pattern3.16999308
3MP0006054_spinal_hemorrhage2.90423490
4MP0003279_aneurysm2.89670323
5MP0005257_abnormal_intraocular_pressure2.87865213
6MP0003122_maternal_imprinting2.55633633
7MP0003283_abnormal_digestive_organ2.54009134
8MP0003385_abnormal_body_wall2.40563778
9MP0000778_abnormal_nervous_system2.34633437
10MP0005503_abnormal_tendon_morphology2.18040471
11MP0009250_abnormal_appendicular_skeleto2.12675591
12MP0001299_abnormal_eye_distance/2.11469109
13MP0003635_abnormal_synaptic_transmissio2.07416804
14MP0000566_synostosis1.98127621
15MP0000920_abnormal_myelination1.96918436
16MP0005171_absent_coat_pigmentation1.96064424
17MP0004272_abnormal_basement_membrane1.96016258
18MP0000537_abnormal_urethra_morphology1.94034147
19MP0000534_abnormal_ureter_morphology1.93401510
20MP0008438_abnormal_cutaneous_collagen1.91695988
21MP0005623_abnormal_meninges_morphology1.81974166
22MP0001486_abnormal_startle_reflex1.78344920
23MP0003942_abnormal_urinary_system1.75651666
24MP0004270_analgesia1.75412627
25MP0010030_abnormal_orbit_morphology1.75032828
26MP0003937_abnormal_limbs/digits/tail_de1.73471012
27MP0002064_seizures1.72771319
28MP0009745_abnormal_behavioral_response1.68798145
29MP0003941_abnormal_skin_development1.68085105
30MP0002272_abnormal_nervous_system1.67704000
31MP0004134_abnormal_chest_morphology1.66387941
32MP0004885_abnormal_endolymph1.61315139
33MP0002063_abnormal_learning/memory/cond1.61288356
34MP0003705_abnormal_hypodermis_morpholog1.57231988
35MP0000049_abnormal_middle_ear1.56916243
36MP0000462_abnormal_digestive_system1.56490055
37MP0009046_muscle_twitch1.54617565
38MP0003755_abnormal_palate_morphology1.54431755
39MP0009384_cardiac_valve_regurgitation1.54316857
40MP0000762_abnormal_tongue_morphology1.53435524
41MP0000767_abnormal_smooth_muscle1.52623522
42MP0003787_abnormal_imprinting1.52419321
43MP0003136_yellow_coat_color1.51921068
44MP0005187_abnormal_penis_morphology1.48850255
45MP0002572_abnormal_emotion/affect_behav1.47994171
46MP0003121_genomic_imprinting1.47492542
47MP0002735_abnormal_chemical_nociception1.45038969
48MP0001177_atelectasis1.38906822
49MP0002938_white_spotting1.38134031
50MP0005595_abnormal_vascular_smooth1.37144470
51MP0010386_abnormal_urinary_bladder1.35004734
52MP0000013_abnormal_adipose_tissue1.34328536
53MP0003938_abnormal_ear_development1.33981331
54MP0002734_abnormal_mechanical_nocicepti1.33952863
55MP0005409_darkened_coat_color1.33527401
56MP0001346_abnormal_lacrimal_gland1.33169423
57MP0001968_abnormal_touch/_nociception1.32023981
58MP0002249_abnormal_larynx_morphology1.30727045
59MP0005367_renal/urinary_system_phenotyp1.29877226
60MP0000516_abnormal_urinary_system1.29877226
61MP0010678_abnormal_skin_adnexa1.29496612
62MP0001542_abnormal_bone_strength1.27589285
63MP0002233_abnormal_nose_morphology1.27336801
64MP0009053_abnormal_anal_canal1.26006283
65MP0000538_abnormal_urinary_bladder1.24313874
66MP0004858_abnormal_nervous_system1.23945095
67MP0003690_abnormal_glial_cell1.23926708
68MP0002184_abnormal_innervation1.23444186
69MP0003123_paternal_imprinting1.23354196
70MP0004215_abnormal_myocardial_fiber1.22312597
71MP0003950_abnormal_plasma_membrane1.21482224
72MP0010368_abnormal_lymphatic_system1.20797100
73MP0000955_abnormal_spinal_cord1.20762083
74MP0002108_abnormal_muscle_morphology1.20736437
75MP0001485_abnormal_pinna_reflex1.19734705
76MP0002896_abnormal_bone_mineralization1.18682745
77MP0002882_abnormal_neuron_morphology1.18312006
78MP0000751_myopathy1.18203018
79MP0003935_abnormal_craniofacial_develop1.17681823
80MP0000428_abnormal_craniofacial_morphol1.17477946
81MP0004742_abnormal_vestibular_system1.16909649
82MP0003634_abnormal_glial_cell1.12965036
83MP0001440_abnormal_grooming_behavior1.11834170
84MP0004145_abnormal_muscle_electrophysio1.10759001
85MP0002116_abnormal_craniofacial_bone1.10346633
86MP0002067_abnormal_sensory_capabilities1.08375751
87MP0002932_abnormal_joint_morphology1.07853659
88MP0009780_abnormal_chondrocyte_physiolo1.07085464
89MP0008569_lethality_at_weaning1.05814923
90MP0000383_abnormal_hair_follicle1.03957619
91MP0002295_abnormal_pulmonary_circulatio1.03655031
92MP0001984_abnormal_olfaction1.02630703
93MP0001879_abnormal_lymphatic_vessel1.02428068
94MP0000569_abnormal_digit_pigmentation1.01854931
95MP0005423_abnormal_somatic_nervous1.01354093
96MP0001905_abnormal_dopamine_level1.01131347
97MP0002102_abnormal_ear_morphology1.00255939
98MP0003091_abnormal_cell_migration1.00118457
99MP0001340_abnormal_eyelid_morphology0.99497565
100MP0005620_abnormal_muscle_contractility0.99491975
101MP0002115_abnormal_skeleton_extremities0.98835685
102MP0000372_irregular_coat_pigmentation0.98672337
103MP0002736_abnormal_nociception_after0.98400407
104MP0005023_abnormal_wound_healing0.98074602
105MP0006276_abnormal_autonomic_nervous0.97619801
106MP0002557_abnormal_social/conspecific_i0.97253135
107MP0002060_abnormal_skin_morphology0.96333525
108MP0003115_abnormal_respiratory_system0.95036457
109MP0002152_abnormal_brain_morphology0.94822943
110MP0003329_amyloid_beta_deposits0.94551856
111MP0001501_abnormal_sleep_pattern0.94187149
112MP0001970_abnormal_pain_threshold0.93662979
113MP0003861_abnormal_nervous_system0.93544523
114MP0010352_gastrointestinal_tract_polyps0.93528098
115MP0005253_abnormal_eye_physiology0.92505268
116MP0003632_abnormal_nervous_system0.91378495
117MP0005248_abnormal_Harderian_gland0.90689066
118MP0006072_abnormal_retinal_apoptosis0.90539178
119MP0003566_abnormal_cell_adhesion0.90190637
120MP0002254_reproductive_system_inflammat0.89952870
121MP0000432_abnormal_head_morphology0.88937749
122MP0002109_abnormal_limb_morphology0.88395736
123MP0000631_abnormal_neuroendocrine_gland0.87985129
124MP0002837_dystrophic_cardiac_calcinosis0.87466688
125MP0005508_abnormal_skeleton_morphology0.87232732
126MP0002009_preneoplasia0.87001294
127MP0003119_abnormal_digestive_system0.86929595
128MP0005197_abnormal_uvea_morphology0.86723851
129MP0004084_abnormal_cardiac_muscle0.86715721
130MP0002066_abnormal_motor_capabilities/c0.86671984
131MP0001270_distended_abdomen0.86322818
132MP0004085_abnormal_heartbeat0.85889715
133MP0008775_abnormal_heart_ventricle0.85707129
134MP0000163_abnormal_cartilage_morphology0.85645831
135MP0002752_abnormal_somatic_nervous0.85091684
136MP0000026_abnormal_inner_ear0.84171910
137MP0002177_abnormal_outer_ear0.83039393
138MP0002114_abnormal_axial_skeleton0.82012933
139MP0001963_abnormal_hearing_physiology0.81838367
140MP0008789_abnormal_olfactory_epithelium0.81648492
141MP0005275_abnormal_skin_tensile0.80916150
142MP0001958_emphysema0.80254080
143MP0002733_abnormal_thermal_nociception0.79606214
144MP0002638_abnormal_pupillary_reflex0.78858575
145MP0000230_abnormal_systemic_arterial0.78389168
146MP0005551_abnormal_eye_electrophysiolog0.73840060
147MP0005408_hypopigmentation0.72196144
148MP0002128_abnormal_blood_circulation0.70305367
149MP0002282_abnormal_trachea_morphology0.69867761
150MP0002909_abnormal_adrenal_gland0.68334292
151MP0003137_abnormal_impulse_conducting0.67368700
152MP0001756_abnormal_urination0.64879960
153MP0006138_congestive_heart_failure0.64720325
154MP0005174_abnormal_tail_pigmentation0.64003239
155MP0002168_other_aberrant_phenotype0.63060974
156MP0005391_vision/eye_phenotype0.61660125
157MP0002972_abnormal_cardiac_muscle0.60238664
158MP0000427_abnormal_hair_cycle0.59900937
159MP0002697_abnormal_eye_size0.59513721
160MP0000639_abnormal_adrenal_gland0.59245211

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.56160848
2Aortic dissection (HP:0002647)4.29652835
3Aortic aneurysm (HP:0004942)4.16272072
4Soft skin (HP:0000977)4.10011119
5Follicular hyperkeratosis (HP:0007502)3.92086375
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.75330493
7Short 4th metacarpal (HP:0010044)3.75330493
8Vascular tortuosity (HP:0004948)3.56894728
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.51940246
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.51940246
11Hypoplastic ischia (HP:0003175)3.50663999
12Coronal craniosynostosis (HP:0004440)3.43009237
13Abnormality of the ischium (HP:0003174)3.42889195
14Neonatal short-limb short stature (HP:0008921)3.42302442
15Bladder diverticulum (HP:0000015)3.26394841
16Arterial tortuosity (HP:0005116)3.09108529
17Atrophic scars (HP:0001075)2.98185672
18Insidious onset (HP:0003587)2.95853253
19Termporal pattern (HP:0011008)2.95853253
20Shallow orbits (HP:0000586)2.90614204
21Abnormality of the 4th metacarpal (HP:0010012)2.87662333
22Bowel diverticulosis (HP:0005222)2.87521059
23Abnormality of the corticospinal tract (HP:0002492)2.84805361
24Ankle contracture (HP:0006466)2.81180581
25Genu recurvatum (HP:0002816)2.78608520
26Broad metatarsal (HP:0001783)2.76414089
27Abnormality of dentin (HP:0010299)2.75679830
28Cutaneous finger syndactyly (HP:0010554)2.72397638
29Midline defect of the nose (HP:0004122)2.69276584
30Microglossia (HP:0000171)2.68113175
31Focal motor seizures (HP:0011153)2.66390076
32Aplasia/Hypoplasia of the hallux (HP:0008362)2.61120380
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.60243536
34Hypoplasia of the fovea (HP:0007750)2.60243536
35Anteriorly placed anus (HP:0001545)2.57806319
36Buphthalmos (HP:0000557)2.52602725
37Type 1 muscle fiber predominance (HP:0003803)2.52522193
38Cervical subluxation (HP:0003308)2.48064798
39Increased corneal curvature (HP:0100692)2.46129376
40Keratoconus (HP:0000563)2.46129376
41Wormian bones (HP:0002645)2.44615154
42Fragile skin (HP:0001030)2.43845321
43Mitral stenosis (HP:0001718)2.43835859
44Increased circulating renin level (HP:0000848)2.41333221
45Abnormality of the phalanges of the 2nd finger (HP:0009541)2.36844010
46Humeroradial synostosis (HP:0003041)2.36705984
47Synostosis involving the elbow (HP:0003938)2.36705984
48Abnormality of the parietal bone (HP:0002696)2.35864825
49Aplasia involving bones of the extremities (HP:0009825)2.32633106
50Aplasia involving bones of the upper limbs (HP:0009823)2.32633106
51Aplasia of the phalanges of the hand (HP:0009802)2.32633106
52Cutaneous syndactyly (HP:0012725)2.31034317
53Action tremor (HP:0002345)2.30795099
54Abnormality of the middle phalanges of the toes (HP:0010183)2.27410010
55Hepatoblastoma (HP:0002884)2.26782793
56Alacrima (HP:0000522)2.25735756
57Striae distensae (HP:0001065)2.24961252
58Turricephaly (HP:0000262)2.24096981
59Hemiparesis (HP:0001269)2.22195310
60Large for gestational age (HP:0001520)2.20121327
61Atonic seizures (HP:0010819)2.18715053
62Abnormality of the fovea (HP:0000493)2.17000240
63Mitral valve prolapse (HP:0001634)2.16598915
64Cerebral aneurysm (HP:0004944)2.16583245
65Mild short stature (HP:0003502)2.16210104
66Dilatation of the ascending aorta (HP:0005111)2.15352655
67Hyperextensible skin (HP:0000974)2.12454179
68Slender build (HP:0001533)2.11393977
69Neurofibrillary tangles (HP:0002185)2.10914564
70Focal seizures (HP:0007359)2.08685970
71Broad toe (HP:0001837)2.06649957
72Prominent supraorbital ridges (HP:0000336)2.05580631
73Spondylolisthesis (HP:0003302)2.05531870
74Chin dimple (HP:0010751)2.04719755
75Gingival overgrowth (HP:0000212)2.04638916
76Peritonitis (HP:0002586)2.03669350
77Sensory axonal neuropathy (HP:0003390)2.02410343
78Bell-shaped thorax (HP:0001591)2.01776435
79Morphological abnormality of the middle ear (HP:0008609)2.01620258
80Abnormality of the nasolacrimal system (HP:0000614)2.01194071
81White forelock (HP:0002211)2.00736292
82Aqueductal stenosis (HP:0002410)2.00057129
83Congenital, generalized hypertrichosis (HP:0004540)1.98960777
84Wide anterior fontanel (HP:0000260)1.98846312
85Hypoventilation (HP:0002791)1.98176337
86Round ear (HP:0100830)1.97051050
87Aplasia/Hypoplasia of the macula (HP:0008059)1.95760282
88Abnormality of incisor morphology (HP:0011063)1.95225528
89Osteoarthritis (HP:0002758)1.93881028
90Blue irides (HP:0000635)1.93685830
91Limited hip movement (HP:0008800)1.92426053
92Cardiovascular calcification (HP:0011915)1.91880258
93Blue sclerae (HP:0000592)1.91331418
94Myokymia (HP:0002411)1.91071603
95Mesomelia (HP:0003027)1.90763411
96Hypoplastic nipples (HP:0002557)1.90388575
97Delayed gross motor development (HP:0002194)1.87990833
98Trigonocephaly (HP:0000243)1.87560560
99Spinal rigidity (HP:0003306)1.86672419
100Abnormality of the phalanges of the hallux (HP:0010057)1.86003086
101Atrial fibrillation (HP:0005110)1.85797024
102Abnormality of the 2nd finger (HP:0004100)1.85577694
103Aortic valve stenosis (HP:0001650)1.84960011
104Patchy hypopigmentation of hair (HP:0011365)1.84634085
105Myelomeningocele (HP:0002475)1.83408146
106Narrow nasal bridge (HP:0000446)1.83067533
107Aplasia/Hypoplasia of the clavicles (HP:0006710)1.82416013
108Ulnar claw (HP:0001178)1.81109699
109Lymphangioma (HP:0100764)1.81106734
110Abnormality of the anterior chamber (HP:0000593)1.80932188
111Ovoid vertebral bodies (HP:0003300)1.80602126
112Broad hallux (HP:0010055)1.80463648
113Aplasia/Hypoplasia affecting the retina (HP:0008061)1.80456407
114Broad ribs (HP:0000885)1.80292159
115Broad-based gait (HP:0002136)1.80063783
116Onion bulb formation (HP:0003383)1.79913745
117Long nose (HP:0003189)1.79694339
118Premature skin wrinkling (HP:0100678)1.78921240
119Drooling (HP:0002307)1.78747356
120Excessive salivation (HP:0003781)1.78747356
121Cupped ear (HP:0000378)1.78684829
122Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.77967355
123Spastic gait (HP:0002064)1.77755990
124Decreased lacrimation (HP:0000633)1.76577028
125Flat face (HP:0012368)1.76553070
126Aortic regurgitation (HP:0001659)1.76330057
127Epileptic encephalopathy (HP:0200134)1.75848141
128Intestinal atresia (HP:0011100)1.74483354
129Deviation of the hallux (HP:0010051)1.74406975
130Aneurysm (HP:0002617)1.74320486
131Knee flexion contracture (HP:0006380)1.72428319
132Wrist flexion contracture (HP:0001239)1.72062138
133Short clavicles (HP:0000894)1.71431320
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70671724
135Premature rupture of membranes (HP:0001788)1.70418056
136Abnormality of the distal phalanx of the thumb (HP:0009617)1.69688357
137Nasolacrimal duct obstruction (HP:0000579)1.69645002
138Peripheral hypomyelination (HP:0007182)1.69500549
139Preaxial foot polydactyly (HP:0001841)1.69425188
140Pulmonary artery stenosis (HP:0004415)1.68796289
141Supernumerary ribs (HP:0005815)1.68255953
142Chorioretinal atrophy (HP:0000533)1.67637945
143Ectopia lentis (HP:0001083)1.67329649
144Hallux valgus (HP:0001822)1.67327338
145Hammertoe (HP:0001765)1.67296116
146Abnormality of the lacrimal duct (HP:0011481)1.67215552
147Joint laxity (HP:0001388)1.67191856
148Bifid scrotum (HP:0000048)1.67104160
149Hematochezia (HP:0002573)1.66876321
150Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.65834981
151Progressive cerebellar ataxia (HP:0002073)1.64916762
152Hyperventilation (HP:0002883)1.64240959
153Esophageal atresia (HP:0002032)1.64127610
154Absent frontal sinuses (HP:0002688)1.64009516
155Short hallux (HP:0010109)1.62471028
156Widely spaced teeth (HP:0000687)1.62165227
157Infantile muscular hypotonia (HP:0008947)1.61262928
158Short metatarsal (HP:0010743)1.61190449
159Osteolytic defects of the phalanges of the hand (HP:0009771)1.60641891
160Osteolytic defects of the hand bones (HP:0009699)1.60641891
161Hip contracture (HP:0003273)1.59829211
162Tibial bowing (HP:0002982)1.58806265
163Venous insufficiency (HP:0005293)1.58584336
164Intention tremor (HP:0002080)1.58563857
165Absent speech (HP:0001344)1.58434296
166Abnormal delivery (HP:0001787)1.58367480
167Anophthalmia (HP:0000528)1.56688637
168Cerebral inclusion bodies (HP:0100314)1.56466107
169Hypoplasia of the iris (HP:0007676)1.56330204
170Overgrowth (HP:0001548)1.56285400
171Renal duplication (HP:0000075)1.55709406
172Renal hypoplasia (HP:0000089)1.54444694
173Bifid tongue (HP:0010297)1.53951788
174Ankle clonus (HP:0011448)1.53380258
175Dysmetria (HP:0001310)1.53296025
176Relative macrocephaly (HP:0004482)1.52365889
177Narrow palate (HP:0000189)1.51957731
178Thickened helices (HP:0000391)1.51755723
179Primary atrial arrhythmia (HP:0001692)1.51651679
180Intellectual disability, moderate (HP:0002342)1.51626685
181Enlarged penis (HP:0000040)1.51490035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.37559224
2MYLK3.37418751
3TNIK3.31029385
4NTRK32.98594819
5OXSR12.85871588
6EPHA42.51699619
7FGFR22.45755951
8WNK42.24188607
9CASK2.17218007
10TYRO32.12407821
11EPHB22.04189954
12TIE12.00740050
13EPHB11.96744350
14WNK11.86503720
15LATS11.86404791
16MAPK131.81366540
17DDR21.73014760
18MAP3K41.61239893
19BCR1.56366135
20STK38L1.56358363
21NTRK11.54789699
22GRK11.54615568
23CAMK1G1.50533452
24BMPR1B1.50040932
25NEK91.41812101
26EPHA31.40758112
27MARK11.39140159
28PAK61.35671517
29PRPF4B1.35345727
30UHMK11.28741443
31MINK11.28344381
32ADRBK11.27280685
33SGK2231.25028591
34SGK4941.25028591
35PDGFRA1.24632542
36PNCK1.22384377
37PRKD31.21001765
38PKN11.20825370
39DMPK1.20098155
40PAK31.18871696
41NTRK21.18459660
42MAPKAPK51.18017864
43MAP3K21.14728212
44LATS21.13877877
45ADRBK21.11846601
46STK31.09178000
47LMTK21.06675342
48FER1.06355875
49FES1.04187854
50NEK61.02203603
51ROCK21.01966820
52IRAK21.01187938
53WNK31.00822605
54CAMK2B1.00284507
55MAP4K21.00246215
56PRKD20.98879279
57TGFBR20.98615786
58PDGFRB0.98218537
59KIT0.98132561
60MAP2K70.97544263
61TRPM70.96709775
62ACVR1B0.95396602
63NLK0.95147084
64MAPK70.94755575
65CSNK1A1L0.92881771
66ICK0.92030334
67FGFR30.91722323
68PINK10.91409919
69PLK20.90957733
70CAMK2A0.89995235
71INSRR0.88595876
72ROCK10.88558539
73CDK50.85967196
74MAP3K90.85409313
75CAMK1D0.85328135
76CSNK1G20.85250577
77ERBB40.84344168
78MET0.84043145
79PRKCE0.83563439
80WEE10.83448177
81KSR10.83119940
82MARK20.82025866
83KSR20.80361587
84CLK10.75363144
85PTK20.74074376
86PRKCH0.73211901
87CSNK1G10.73210840
88CDC42BPA0.71505981
89FGFR10.70644130
90PIK3CG0.67814336
91ABL20.66932210
92FRK0.66880815
93MKNK10.66060530
94RIPK10.65955378
95PIK3CA0.65852057
96PTK2B0.65844134
97TGFBR10.65546121
98MAPK150.64831564
99ERBB30.62024970
100CAMK2D0.61679166
101AKT30.61520419
102STK380.61085991
103CDK140.60652876
104OBSCN0.60560854
105SGK20.60015224
106FGR0.59706675
107CSNK1G30.58346352
108PRKCG0.57744851
109PHKG20.56359450
110PHKG10.56359450
111ERBB20.56050571
112PRKG10.55914041
113GRK70.54253582
114SIK10.53628984
115MAP2K10.53582904
116SGK10.53379845
117CDK180.52933714
118FYN0.52564729
119CDK30.52427465
120MAP2K40.51797138
121MKNK20.51683537
122CDK150.51215845
123LIMK10.48176179
124TTN0.48122512
125PAK20.46044592
126SGK30.45678010
127PRKD10.45257718
128GSK3A0.44884351
129NUAK10.44042418
130INSR0.43591284
131MAPK100.43017741
132RET0.42501936
133CAMK10.42464593
134CDK11A0.42019074
135CAMK2G0.41121186
136PRKG20.38319182
137FLT30.37672647
138PDK20.37296368
139RPS6KA20.35146885

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.62341134
2* Axon guidance_Homo sapiens_hsa043602.46418386
3Nicotine addiction_Homo sapiens_hsa050332.30097750
4Steroid biosynthesis_Homo sapiens_hsa001002.17801646
5Glutamatergic synapse_Homo sapiens_hsa047242.06202993
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97855993
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94415379
8Circadian entrainment_Homo sapiens_hsa047131.93473983
9GABAergic synapse_Homo sapiens_hsa047271.83004172
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.81483981
11Long-term potentiation_Homo sapiens_hsa047201.73915643
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67822540
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63141180
14ECM-receptor interaction_Homo sapiens_hsa045121.60198929
15Long-term depression_Homo sapiens_hsa047301.59144297
16Cholinergic synapse_Homo sapiens_hsa047251.57397678
17Hedgehog signaling pathway_Homo sapiens_hsa043401.53338366
18Serotonergic synapse_Homo sapiens_hsa047261.52870653
19Dopaminergic synapse_Homo sapiens_hsa047281.51351990
20Amphetamine addiction_Homo sapiens_hsa050311.47328603
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47205511
22Morphine addiction_Homo sapiens_hsa050321.46675488
23Basal cell carcinoma_Homo sapiens_hsa052171.46241329
24Synaptic vesicle cycle_Homo sapiens_hsa047211.40902640
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.40282184
26Renin secretion_Homo sapiens_hsa049241.39084400
27Salivary secretion_Homo sapiens_hsa049701.38915279
28Gastric acid secretion_Homo sapiens_hsa049711.38540075
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38063526
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37040061
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37036559
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30621835
33Ether lipid metabolism_Homo sapiens_hsa005651.30432000
34Gap junction_Homo sapiens_hsa045401.24583412
35Fatty acid elongation_Homo sapiens_hsa000621.21545598
36Melanogenesis_Homo sapiens_hsa049161.20801177
37Cocaine addiction_Homo sapiens_hsa050301.18779888
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18117225
39Wnt signaling pathway_Homo sapiens_hsa043101.15838636
40Oxytocin signaling pathway_Homo sapiens_hsa049211.15689887
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15497523
42Renal cell carcinoma_Homo sapiens_hsa052111.14272217
43cAMP signaling pathway_Homo sapiens_hsa040241.14072495
44Hippo signaling pathway_Homo sapiens_hsa043901.13705241
45Focal adhesion_Homo sapiens_hsa045101.10310241
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09935837
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09173516
48Dorso-ventral axis formation_Homo sapiens_hsa043201.09056208
49Protein digestion and absorption_Homo sapiens_hsa049741.08860049
50GnRH signaling pathway_Homo sapiens_hsa049121.08508201
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07928502
52ErbB signaling pathway_Homo sapiens_hsa040121.07363004
53Tight junction_Homo sapiens_hsa045301.06535805
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05069791
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.04961779
56Glioma_Homo sapiens_hsa052141.04721695
57Estrogen signaling pathway_Homo sapiens_hsa049151.04318021
58Calcium signaling pathway_Homo sapiens_hsa040201.04292085
59Phospholipase D signaling pathway_Homo sapiens_hsa040721.03947598
60Ovarian steroidogenesis_Homo sapiens_hsa049131.03688134
61Insulin secretion_Homo sapiens_hsa049111.02934162
62Choline metabolism in cancer_Homo sapiens_hsa052311.01880529
63Olfactory transduction_Homo sapiens_hsa047400.99094939
64Taste transduction_Homo sapiens_hsa047420.96583544
65Dilated cardiomyopathy_Homo sapiens_hsa054140.94783918
66Ras signaling pathway_Homo sapiens_hsa040140.92364296
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91422305
68Adherens junction_Homo sapiens_hsa045200.90255513
69Vibrio cholerae infection_Homo sapiens_hsa051100.89498120
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89371618
71Prostate cancer_Homo sapiens_hsa052150.88683855
72Small cell lung cancer_Homo sapiens_hsa052220.87129262
73Pancreatic secretion_Homo sapiens_hsa049720.86460574
74Sulfur metabolism_Homo sapiens_hsa009200.86268599
75Phototransduction_Homo sapiens_hsa047440.86134288
76Type II diabetes mellitus_Homo sapiens_hsa049300.85833786
77Collecting duct acid secretion_Homo sapiens_hsa049660.85832776
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85459176
79Protein export_Homo sapiens_hsa030600.83082456
80Butanoate metabolism_Homo sapiens_hsa006500.82669955
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82152167
82ABC transporters_Homo sapiens_hsa020100.80750474
83Proteoglycans in cancer_Homo sapiens_hsa052050.80263736
84TGF-beta signaling pathway_Homo sapiens_hsa043500.78890344
85Thyroid hormone synthesis_Homo sapiens_hsa049180.77264658
86Rap1 signaling pathway_Homo sapiens_hsa040150.76725828
87Cardiac muscle contraction_Homo sapiens_hsa042600.76037801
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75532952
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74075480
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73627298
91Bile secretion_Homo sapiens_hsa049760.73192940
92Circadian rhythm_Homo sapiens_hsa047100.72512858
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70199243
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70082458
95Histidine metabolism_Homo sapiens_hsa003400.69897816
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69477055
97Mineral absorption_Homo sapiens_hsa049780.68854477
98Melanoma_Homo sapiens_hsa052180.68565052
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68482455
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.68377003
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.68255626
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66626935
103Tryptophan metabolism_Homo sapiens_hsa003800.64662931
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64547021
105MAPK signaling pathway_Homo sapiens_hsa040100.64482276
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62768681
107Endometrial cancer_Homo sapiens_hsa052130.62463281
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61822782
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61228763
110Amoebiasis_Homo sapiens_hsa051460.60935829
111MicroRNAs in cancer_Homo sapiens_hsa052060.60269315
112Nitrogen metabolism_Homo sapiens_hsa009100.60195268
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59180212
114Colorectal cancer_Homo sapiens_hsa052100.58000381
115Sphingolipid metabolism_Homo sapiens_hsa006000.56588812
116Pathways in cancer_Homo sapiens_hsa052000.52992206
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49769264
118Retinol metabolism_Homo sapiens_hsa008300.49337908
119Endocytosis_Homo sapiens_hsa041440.49223261
120Propanoate metabolism_Homo sapiens_hsa006400.49153491
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49141761
122Lysine degradation_Homo sapiens_hsa003100.48408896
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47274681
124Selenocompound metabolism_Homo sapiens_hsa004500.46718835
125Pancreatic cancer_Homo sapiens_hsa052120.44872552
126Renin-angiotensin system_Homo sapiens_hsa046140.43931421

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