SEMA5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)7.38352709
2lateral sprouting from an epithelium (GO:0060601)5.22182851
3positive regulation of male gonad development (GO:2000020)4.64421062
4sex determination (GO:0007530)4.54968192
5regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.30624508
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.24915389
7regulation of male gonad development (GO:2000018)4.24031714
8establishment of mitochondrion localization (GO:0051654)4.02241511
9locomotory exploration behavior (GO:0035641)4.01393167
10regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.99746520
11neuron cell-cell adhesion (GO:0007158)3.97568879
12sex differentiation (GO:0007548)3.92540228
13regulation of respiratory system process (GO:0044065)3.87768967
14retinal ganglion cell axon guidance (GO:0031290)3.83258310
15pyrimidine nucleobase catabolic process (GO:0006208)3.79500277
16postsynaptic membrane organization (GO:0001941)3.72930528
17axon ensheathment in central nervous system (GO:0032291)3.72891537
18central nervous system myelination (GO:0022010)3.72891537
19nonmotile primary cilium assembly (GO:0035058)3.72116677
20male sex determination (GO:0030238)3.67729894
21glial cell proliferation (GO:0014009)3.65388189
22negative regulation of oligodendrocyte differentiation (GO:0048715)3.60300993
23piRNA metabolic process (GO:0034587)3.52871757
24establishment of nucleus localization (GO:0040023)3.52037477
25limb bud formation (GO:0060174)3.50788580
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.49164475
27layer formation in cerebral cortex (GO:0021819)3.46553569
28auditory behavior (GO:0031223)3.45502532
29regulation of respiratory gaseous exchange (GO:0043576)3.42787620
30planar cell polarity pathway involved in neural tube closure (GO:0090179)3.41272087
31regulation of glutamate receptor signaling pathway (GO:1900449)3.37387099
32cellular response to cholesterol (GO:0071397)3.36716830
33pattern specification involved in kidney development (GO:0061004)3.35848612
34central nervous system projection neuron axonogenesis (GO:0021952)3.30318027
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.29748929
36negative regulation of astrocyte differentiation (GO:0048712)3.29065664
37positive regulation of vascular permeability (GO:0043117)3.27786770
38innervation (GO:0060384)3.25604395
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.23814543
40neuron fate determination (GO:0048664)3.21327960
41heart valve formation (GO:0003188)3.19320972
42head development (GO:0060322)3.19236363
43behavioral response to nicotine (GO:0035095)3.18163852
44response to auditory stimulus (GO:0010996)3.15793608
45limb development (GO:0060173)3.14866102
46appendage development (GO:0048736)3.14866102
47cell proliferation in forebrain (GO:0021846)3.12952017
48ovulation cycle (GO:0042698)3.12457262
49neuronal stem cell maintenance (GO:0097150)3.11699503
50paraxial mesoderm development (GO:0048339)3.11648994
51transmission of nerve impulse (GO:0019226)3.10907415
52vocalization behavior (GO:0071625)3.10544404
53camera-type eye morphogenesis (GO:0048593)3.09617268
54presynaptic membrane assembly (GO:0097105)3.09566871
55startle response (GO:0001964)3.06147111
56tongue development (GO:0043586)3.05485256
57establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.04984242
58mitochondrion transport along microtubule (GO:0047497)3.04984242
59olfactory bulb development (GO:0021772)3.03563318
60positive regulation of synapse assembly (GO:0051965)3.03197226
61protein localization to synapse (GO:0035418)3.02243527
62synapse assembly (GO:0007416)3.01972713
63positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.01183098
64radial glial cell differentiation (GO:0060019)3.00140840
65cell migration in hindbrain (GO:0021535)2.98359729
66neurotransmitter-gated ion channel clustering (GO:0072578)2.96512726
67establishment of planar polarity (GO:0001736)2.96455633
68establishment of tissue polarity (GO:0007164)2.96455633
69lens fiber cell development (GO:0070307)2.96286146
70epithelial cilium movement (GO:0003351)2.95644946
71regulation of NFAT protein import into nucleus (GO:0051532)2.92068822
72neuron recognition (GO:0008038)2.91930118
73dendritic spine morphogenesis (GO:0060997)2.91355959
74synaptic transmission, glutamatergic (GO:0035249)2.88629580
75regulation of meiosis I (GO:0060631)2.86779850
76RNA localization (GO:0006403)2.85418578
77axonal fasciculation (GO:0007413)2.84426394
78exploration behavior (GO:0035640)2.83926880
79positive regulation of meiosis (GO:0045836)2.81053787
80chondroitin sulfate catabolic process (GO:0030207)2.80678333
81cilium or flagellum-dependent cell motility (GO:0001539)2.80582940
82dendrite morphogenesis (GO:0048813)2.80284843
83negative regulation of glial cell differentiation (GO:0045686)2.78568809
84negative regulation of smoothened signaling pathway (GO:0045879)2.78433782
85synaptic vesicle docking involved in exocytosis (GO:0016081)2.77478507
86positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76686938
87neuron migration (GO:0001764)2.76410169
88spinal cord development (GO:0021510)2.75675496
89positive regulation of dendritic spine morphogenesis (GO:0061003)2.75608782
90apical protein localization (GO:0045176)2.74736686
91hindbrain development (GO:0030902)2.74179430
92regulation of synapse structural plasticity (GO:0051823)2.72912193
93intraciliary transport (GO:0042073)2.71733518
94spinal cord association neuron differentiation (GO:0021527)2.70751725
95calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70238274
96regulation of development, heterochronic (GO:0040034)2.69976690
97forebrain neuron differentiation (GO:0021879)2.68956841
98regulation of timing of cell differentiation (GO:0048505)2.68643888
99DNA methylation involved in gamete generation (GO:0043046)2.67922271
100Notch signaling involved in heart development (GO:0061314)2.67481885
101cochlea morphogenesis (GO:0090103)2.65689154
102Sertoli cell development (GO:0060009)2.65373712
103negative regulation of neurotransmitter transport (GO:0051589)2.63783921
104cerebral cortex cell migration (GO:0021795)2.63580539
105auditory receptor cell differentiation (GO:0042491)2.62987984
106regulation of short-term neuronal synaptic plasticity (GO:0048172)2.61725325
107cellular response to sterol (GO:0036315)2.61170572
108presynaptic membrane organization (GO:0097090)2.60661855
109central nervous system neuron development (GO:0021954)2.60610896
110astrocyte development (GO:0014002)2.60212058
111mechanosensory behavior (GO:0007638)2.60126797
112righting reflex (GO:0060013)2.59858796
113retinal rod cell development (GO:0046548)2.59661036
114positive regulation of neuroblast proliferation (GO:0002052)2.59185067
115astrocyte differentiation (GO:0048708)2.59141691
116midbrain development (GO:0030901)2.58978643
117nucleobase catabolic process (GO:0046113)2.58541361
118somite development (GO:0061053)2.58447760
119synaptic vesicle endocytosis (GO:0048488)2.57727385
120regulation of oligodendrocyte differentiation (GO:0048713)2.57517327
121cerebral cortex radially oriented cell migration (GO:0021799)2.57135489
122cranial nerve morphogenesis (GO:0021602)2.55534059
123glutamate receptor signaling pathway (GO:0007215)2.53713829
124ephrin receptor signaling pathway (GO:0048013)2.53283816
125otic vesicle formation (GO:0030916)2.52605478
126response to pheromone (GO:0019236)2.52440234
127cilium movement (GO:0003341)2.52349094
128segment specification (GO:0007379)2.51757395
129negative regulation of axon guidance (GO:1902668)2.51560183
130membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51365199
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.51308062
132synapse organization (GO:0050808)2.51160736
133positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50318278
134negative regulation of sodium ion transport (GO:0010766)2.50032190
135positive regulation of meiotic cell cycle (GO:0051446)2.49710148
136Leydig cell differentiation (GO:0033327)2.48051581
137positive regulation of Notch signaling pathway (GO:0045747)2.47826816
138asymmetric protein localization (GO:0008105)2.47375177
139thalamus development (GO:0021794)2.47323763
140positive regulation of synapse maturation (GO:0090129)2.43814802
141anatomical structure regression (GO:0060033)2.43567119
142nucleus localization (GO:0051647)2.41892925
143hippocampus development (GO:0021766)2.41592705
144male meiosis (GO:0007140)2.41393404
145cerebral cortex neuron differentiation (GO:0021895)2.41035808
146synaptonemal complex assembly (GO:0007130)2.39997104
147glomerular basement membrane development (GO:0032836)2.39961684
148positive regulation of synaptic transmission, GABAergic (GO:0032230)2.39158585
149central nervous system neuron axonogenesis (GO:0021955)2.38917025
150regulation of synapse assembly (GO:0051963)2.38339203
151skeletal muscle organ development (GO:0060538)2.38195310
152enteric nervous system development (GO:0048484)2.37130530
153membrane hyperpolarization (GO:0060081)2.36444106
154regulation of synaptic transmission, glutamatergic (GO:0051966)2.36404797
155regulation of axon extension involved in axon guidance (GO:0048841)2.36107432
156cell communication by electrical coupling (GO:0010644)2.35987738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.35274159
2GBX2_23144817_ChIP-Seq_PC3_Human2.90257912
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88633878
4* EZH2_27304074_Chip-Seq_ESCs_Mouse2.73103735
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73082259
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53669650
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53669650
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48727639
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45363473
10RNF2_27304074_Chip-Seq_ESCs_Mouse2.42871516
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.42584613
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.42145621
13* CBX2_27304074_Chip-Seq_ESCs_Mouse2.40250466
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39145611
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35982375
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33261795
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.30978323
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29888465
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16718499
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07072534
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.06937336
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00528941
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99076643
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92693123
25* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.92229246
26REST_21632747_ChIP-Seq_MESCs_Mouse1.87380213
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86231940
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85977642
29* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79732661
30IGF1R_20145208_ChIP-Seq_DFB_Human1.79103090
31RNF2_27304074_Chip-Seq_NSC_Mouse1.77570494
32DROSHA_22980978_ChIP-Seq_HELA_Human1.77511387
33* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76360579
34* RING1B_27294783_Chip-Seq_ESCs_Mouse1.70304106
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.69646829
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67332084
37RING1B_27294783_Chip-Seq_NPCs_Mouse1.62756957
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58377274
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54593275
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53082424
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52778785
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50284180
43* REST_18959480_ChIP-ChIP_MESCs_Mouse1.50164159
44* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47899070
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47180482
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45286613
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45286613
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.45052752
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44596595
50ZNF274_21170338_ChIP-Seq_K562_Hela1.43395870
51AR_21572438_ChIP-Seq_LNCaP_Human1.43000043
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41198106
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40887359
54* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39416952
55* TP53_20018659_ChIP-ChIP_R1E_Mouse1.36142440
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34493194
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.30904488
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30225621
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29032821
60ELK4_26923725_Chip-Seq_MESODERM_Mouse1.27558084
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25775957
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25305710
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25052703
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24692258
65VDR_22108803_ChIP-Seq_LS180_Human1.23863644
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23806435
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22849939
68TAF15_26573619_Chip-Seq_HEK293_Human1.21815496
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.19105266
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18072360
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16824247
72* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14394464
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14125665
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.14009680
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13649050
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13304986
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.13188508
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12969492
79AR_19668381_ChIP-Seq_PC3_Human1.12674608
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.11723309
81* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11229362
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11100022
83* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10981343
84* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10861240
85FUS_26573619_Chip-Seq_HEK293_Human1.10251237
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.10031649
87EWS_26573619_Chip-Seq_HEK293_Human1.09993250
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09608561
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08729968
90* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08374370
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07980059
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.05869301
93* SMAD4_21799915_ChIP-Seq_A2780_Human1.05308100
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04408577
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04398654
96* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02958739
97SOX9_26525672_Chip-Seq_HEART_Mouse1.02052690
98* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01433739
99SOX2_16153702_ChIP-ChIP_HESCs_Human1.00407884
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.00157601
101SOX2_21211035_ChIP-Seq_LN229_Gbm0.99406587
102POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99046804
103BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98373607
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98236065
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98081938
106* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97896436
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97528529
108* STAT3_23295773_ChIP-Seq_U87_Human0.97378023
109* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97377712
110TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97313674
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96984179
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95942573
113SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95768515
114AR_25329375_ChIP-Seq_VCAP_Human0.95619345
115* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94808023
116P300_19829295_ChIP-Seq_ESCs_Human0.94518980
117* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93939082
118RUNX2_22187159_ChIP-Seq_PCA_Human0.93844602
119WDR5_24793694_ChIP-Seq_LNCAP_Human0.93675582
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92611760
121* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.92317057
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91425805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.19829854
2MP0004859_abnormal_synaptic_plasticity2.82670530
3MP0005423_abnormal_somatic_nervous2.82315035
4MP0000778_abnormal_nervous_system2.64018421
5MP0008995_early_reproductive_senescence2.52279982
6MP0003880_abnormal_central_pattern2.47580203
7MP0000537_abnormal_urethra_morphology2.38825353
8MP0006292_abnormal_olfactory_placode2.26419661
9MP0002638_abnormal_pupillary_reflex2.18381171
10MP0004858_abnormal_nervous_system2.15790886
11MP0000566_synostosis2.11983548
12MP0005377_hearing/vestibular/ear_phenot2.07184738
13MP0003878_abnormal_ear_physiology2.07184738
14MP0008877_abnormal_DNA_methylation2.02397535
15MP0000631_abnormal_neuroendocrine_gland1.97400131
16MP0005646_abnormal_pituitary_gland1.91634714
17MP0000049_abnormal_middle_ear1.87607977
18MP0003635_abnormal_synaptic_transmissio1.81279817
19MP0001486_abnormal_startle_reflex1.71984710
20MP0002063_abnormal_learning/memory/cond1.70004025
21MP0001293_anophthalmia1.68503040
22MP0005171_absent_coat_pigmentation1.68037452
23MP0003283_abnormal_digestive_organ1.67476999
24MP0004885_abnormal_endolymph1.66591299
25MP0002282_abnormal_trachea_morphology1.65911856
26MP0009379_abnormal_foot_pigmentation1.63655098
27MP0002249_abnormal_larynx_morphology1.62033201
28MP0003115_abnormal_respiratory_system1.58860180
29MP0002735_abnormal_chemical_nociception1.56525713
30MP0002572_abnormal_emotion/affect_behav1.55741565
31MP0010030_abnormal_orbit_morphology1.53183098
32MP0002184_abnormal_innervation1.51219267
33MP0002557_abnormal_social/conspecific_i1.49967036
34MP0008789_abnormal_olfactory_epithelium1.49793584
35MP0004742_abnormal_vestibular_system1.49679204
36MP0003119_abnormal_digestive_system1.49253615
37MP0005410_abnormal_fertilization1.48546598
38MP0005499_abnormal_olfactory_system1.46740211
39MP0005394_taste/olfaction_phenotype1.46740211
40MP0002102_abnormal_ear_morphology1.46190322
41MP0003861_abnormal_nervous_system1.45696551
42MP0003879_abnormal_hair_cell1.45429041
43MP0009745_abnormal_behavioral_response1.44911792
44MP0001485_abnormal_pinna_reflex1.42274829
45MP0002822_catalepsy1.40540372
46MP0000428_abnormal_craniofacial_morphol1.40291857
47MP0005248_abnormal_Harderian_gland1.39989901
48MP0003942_abnormal_urinary_system1.39985550
49MP0002233_abnormal_nose_morphology1.39395823
50MP0003938_abnormal_ear_development1.36928204
51MP0002734_abnormal_mechanical_nocicepti1.36640524
52MP0009053_abnormal_anal_canal1.35421096
53MP0003315_abnormal_perineum_morphology1.33956734
54MP0002152_abnormal_brain_morphology1.33075614
55MP0004142_abnormal_muscle_tone1.31909154
56MP0000955_abnormal_spinal_cord1.31820545
57MP0003698_abnormal_male_reproductive1.30598759
58MP0002064_seizures1.30546055
59MP0000026_abnormal_inner_ear1.27859122
60MP0002210_abnormal_sex_determination1.27135682
61MP0003941_abnormal_skin_development1.25181577
62MP0009384_cardiac_valve_regurgitation1.24750942
63MP0002116_abnormal_craniofacial_bone1.23313468
64MP0003136_yellow_coat_color1.21324938
65MP0002882_abnormal_neuron_morphology1.21171412
66MP0002938_white_spotting1.20823690
67MP0006072_abnormal_retinal_apoptosis1.20257744
68MP0003122_maternal_imprinting1.19885206
69MP0003755_abnormal_palate_morphology1.19517600
70MP0003385_abnormal_body_wall1.18129437
71MP0001440_abnormal_grooming_behavior1.17536683
72MP0003787_abnormal_imprinting1.16229312
73MP0006276_abnormal_autonomic_nervous1.14975196
74MP0002751_abnormal_autonomic_nervous1.14794623
75MP0002697_abnormal_eye_size1.11992037
76MP0002067_abnormal_sensory_capabilities1.11761553
77MP0005195_abnormal_posterior_eye1.11270496
78MP0005391_vision/eye_phenotype1.09924492
79MP0001929_abnormal_gametogenesis1.09650840
80MP0001968_abnormal_touch/_nociception1.08792403
81MP0001984_abnormal_olfaction1.08161054
82MP0002272_abnormal_nervous_system1.06475125
83MP0003890_abnormal_embryonic-extraembry1.04609600
84MP0000569_abnormal_digit_pigmentation1.04318464
85MP0001299_abnormal_eye_distance/1.04317661
86MP0004811_abnormal_neuron_physiology1.04261812
87MP0004270_analgesia1.03220243
88MP0004133_heterotaxia1.02398104
89MP0005253_abnormal_eye_physiology1.01531913
90MP0001970_abnormal_pain_threshold1.00900767
91MP0009046_muscle_twitch1.00747842
92MP0002752_abnormal_somatic_nervous1.00480487
93MP0001145_abnormal_male_reproductive1.00344886
94MP0003935_abnormal_craniofacial_develop0.99484888
95MP0003121_genomic_imprinting0.99481813
96MP0005187_abnormal_penis_morphology0.98899705
97MP0001529_abnormal_vocalization0.96578125
98MP0002736_abnormal_nociception_after0.93512649
99MP0000534_abnormal_ureter_morphology0.91486694
100MP0005551_abnormal_eye_electrophysiolog0.91352171
101MP0000467_abnormal_esophagus_morphology0.90992808
102MP0005623_abnormal_meninges_morphology0.90569084
103MP0001286_abnormal_eye_development0.90229833
104MP0005645_abnormal_hypothalamus_physiol0.89823269
105MP0001502_abnormal_circadian_rhythm0.89600963
106MP0002081_perinatal_lethality0.89222974
107MP0002234_abnormal_pharynx_morphology0.88664448
108MP0002932_abnormal_joint_morphology0.88530319
109MP0001177_atelectasis0.87916250
110MP0002733_abnormal_thermal_nociception0.87284639
111MP0002928_abnormal_bile_duct0.86979755
112MP0000653_abnormal_sex_gland0.85762371
113MP0002066_abnormal_motor_capabilities/c0.85639636
114MP0001963_abnormal_hearing_physiology0.85467668
115MP0002909_abnormal_adrenal_gland0.85406507
116MP0003937_abnormal_limbs/digits/tail_de0.85068242
117MP0002092_abnormal_eye_morphology0.84932359
118MP0003632_abnormal_nervous_system0.84763708
119MP0003634_abnormal_glial_cell0.84614710
120MP0005386_behavior/neurological_phenoty0.84427763
121MP0004924_abnormal_behavior0.84427763
122MP0002089_abnormal_postnatal_growth/wei0.83746487
123MP0001905_abnormal_dopamine_level0.79322157
124MP0000647_abnormal_sebaceous_gland0.77807959

Predicted human phenotypes

RankGene SetZ-score
1Sex reversal (HP:0012245)3.72234966
2Abnormal sex determination (HP:0012244)3.72234966
3Gonadal dysgenesis (HP:0000133)3.43614847
4Male pseudohermaphroditism (HP:0000037)3.18130351
5Polyphagia (HP:0002591)3.11853960
6Abnormality of the lower motor neuron (HP:0002366)2.90791863
7Morphological abnormality of the middle ear (HP:0008609)2.90123270
8Male infertility (HP:0003251)2.88540814
9Cortical dysplasia (HP:0002539)2.81106691
10Oligodactyly (HP:0012165)2.78896437
11Gonadotropin excess (HP:0000837)2.70698481
12Short 4th metacarpal (HP:0010044)2.69533192
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.69533192
14Septo-optic dysplasia (HP:0100842)2.58295368
15Retinal dysplasia (HP:0007973)2.57813499
16Absent septum pellucidum (HP:0001331)2.55236492
17Vitreoretinal degeneration (HP:0000655)2.53714405
18Abnormality of the aortic arch (HP:0012303)2.49264573
19Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.49034299
20Myokymia (HP:0002411)2.48791684
21Hemivertebrae (HP:0002937)2.48297614
22Megalencephaly (HP:0001355)2.47708717
23Anophthalmia (HP:0000528)2.47228565
24Gait imbalance (HP:0002141)2.46748845
25Abnormality of the diencephalon (HP:0010662)2.42731489
26Synostosis involving the elbow (HP:0003938)2.39111881
27Humeroradial synostosis (HP:0003041)2.39111881
28Absent/shortened dynein arms (HP:0200106)2.35958782
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.35958782
30Neonatal short-limb short stature (HP:0008921)2.35198165
31Oligodactyly (hands) (HP:0001180)2.34485458
32Pancreatic fibrosis (HP:0100732)2.33543412
33Renovascular hypertension (HP:0100817)2.32694310
34Abnormality of the 4th metacarpal (HP:0010012)2.31627286
35Renal duplication (HP:0000075)2.30579079
36Medial flaring of the eyebrow (HP:0010747)2.30219184
37Nephronophthisis (HP:0000090)2.29626550
38Ankle clonus (HP:0011448)2.28721607
39Obstructive sleep apnea (HP:0002870)2.25778339
40Esophageal atresia (HP:0002032)2.25337580
41Hepatoblastoma (HP:0002884)2.23161599
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.20274661
43Congenital primary aphakia (HP:0007707)2.18751280
44Germ cell neoplasia (HP:0100728)2.18653492
45Genital tract atresia (HP:0001827)2.18174463
46Molar tooth sign on MRI (HP:0002419)2.17298707
47Abnormality of midbrain morphology (HP:0002418)2.17298707
48Nephrogenic diabetes insipidus (HP:0009806)2.16775673
49Lissencephaly (HP:0001339)2.14235976
50Bronchomalacia (HP:0002780)2.14135746
51Midline defect of the nose (HP:0004122)2.12847792
52Pseudobulbar signs (HP:0002200)2.12206760
53Focal motor seizures (HP:0011153)2.11841224
54Vaginal atresia (HP:0000148)2.10900174
55Elfin facies (HP:0004428)2.09872223
56Split foot (HP:0001839)2.08011800
57Cutaneous finger syndactyly (HP:0010554)2.07492778
58Pointed chin (HP:0000307)2.07249514
59Coronal craniosynostosis (HP:0004440)2.05651369
60Abnormal eating behavior (HP:0100738)2.05595446
61Trigonocephaly (HP:0000243)2.03985619
62Pancreatic cysts (HP:0001737)2.03719626
63Gastrointestinal atresia (HP:0002589)2.02612037
64Aplasia/Hypoplasia of the sternum (HP:0006714)2.02597634
65Abnormality of the ischium (HP:0003174)2.01463623
66Hyperventilation (HP:0002883)2.01034514
67Postaxial foot polydactyly (HP:0001830)1.98767877
68Partial duplication of thumb phalanx (HP:0009944)1.98691456
69Abnormality of the renal medulla (HP:0100957)1.98094987
70Aplasia/Hypoplasia of the fibula (HP:0006492)1.97190060
71Broad alveolar ridges (HP:0000187)1.96657519
72Focal seizures (HP:0007359)1.96522609
73Abnormality of the septum pellucidum (HP:0007375)1.96521225
74Anencephaly (HP:0002323)1.94133156
75Meningocele (HP:0002435)1.93144473
76Broad foot (HP:0001769)1.92949657
77Sclerocornea (HP:0000647)1.92831617
78Drooling (HP:0002307)1.91635747
79Excessive salivation (HP:0003781)1.91635747
80Hypoplastic pelvis (HP:0008839)1.90979085
81Overriding aorta (HP:0002623)1.88673430
82Testicular neoplasm (HP:0010788)1.87850666
83Sleep apnea (HP:0010535)1.87165407
84Missing ribs (HP:0000921)1.86212184
85Abnormal number of incisors (HP:0011064)1.85236745
86Cutaneous syndactyly (HP:0012725)1.84929376
87Hyperacusis (HP:0010780)1.83896726
88Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82648932
89Vertebral hypoplasia (HP:0008417)1.82648932
90Insomnia (HP:0100785)1.82635940
91Wide anterior fontanel (HP:0000260)1.82477936
92Aplasia/hypoplasia of the uterus (HP:0008684)1.81983114
93Bilateral microphthalmos (HP:0007633)1.81230787
94Optic nerve hypoplasia (HP:0000609)1.80317401
95Abnormality of the labia minora (HP:0012880)1.80087292
96Myelomeningocele (HP:0002475)1.79795027
97Abnormality of male internal genitalia (HP:0000022)1.78235376
98Hyperglycinemia (HP:0002154)1.78054791
99Alacrima (HP:0000522)1.77731569
100Preaxial foot polydactyly (HP:0001841)1.75868478
101Type II lissencephaly (HP:0007260)1.75706031
102Pachygyria (HP:0001302)1.75516419
103Flat cornea (HP:0007720)1.74620388
104Facial hemangioma (HP:0000329)1.74568130
105Holoprosencephaly (HP:0001360)1.74519861
106Hemiparesis (HP:0001269)1.74463283
107Chronic hepatic failure (HP:0100626)1.73863040
108Abnormal respiratory epithelium morphology (HP:0012253)1.72793468
109Abnormal respiratory motile cilium morphology (HP:0005938)1.72793468
110Aplasia involving bones of the upper limbs (HP:0009823)1.72708474
111Aplasia of the phalanges of the hand (HP:0009802)1.72708474
112Aplasia involving bones of the extremities (HP:0009825)1.72708474
113Preaxial hand polydactyly (HP:0001177)1.72439126
114Abnormality of the antihelix (HP:0009738)1.71512901
115Poor coordination (HP:0002370)1.70325007
116Hip dysplasia (HP:0001385)1.69965392
117Gastroesophageal reflux (HP:0002020)1.69486848
118Chorioretinal atrophy (HP:0000533)1.68836308
119Growth hormone deficiency (HP:0000824)1.68523790
120Morphological abnormality of the inner ear (HP:0011390)1.68092938
121Abnormal ciliary motility (HP:0012262)1.67278510
122Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66476995
123Hypoplasia of the brainstem (HP:0002365)1.66373335
124Aplasia/Hypoplasia of the brainstem (HP:0007362)1.66373335
125Increased nuchal translucency (HP:0010880)1.66287106
126Infertility (HP:0000789)1.65950055
127Skull defect (HP:0001362)1.65803850
128Optic nerve coloboma (HP:0000588)1.65610950
129Obsessive-compulsive behavior (HP:0000722)1.64763854
130Partial duplication of the phalanx of hand (HP:0009999)1.64100646
131Turricephaly (HP:0000262)1.63359715
132Renal dysplasia (HP:0000110)1.62732355
133Supernumerary bones of the axial skeleton (HP:0009144)1.62293992
13411 pairs of ribs (HP:0000878)1.61779905
135Epileptic encephalopathy (HP:0200134)1.61014683
136Abnormal respiratory motile cilium physiology (HP:0012261)1.60826023
137Neoplasm of the heart (HP:0100544)1.60618474
138Intestinal atresia (HP:0011100)1.60449706
139Labial hypoplasia (HP:0000066)1.59800337
140High anterior hairline (HP:0009890)1.59152618
141Specific learning disability (HP:0001328)1.58943081
142Rib fusion (HP:0000902)1.58338439
143Occipital encephalocele (HP:0002085)1.58172825
144True hermaphroditism (HP:0010459)1.57695571
145Shallow orbits (HP:0000586)1.57534602
146Decreased lacrimation (HP:0000633)1.57070609
147Bifid tongue (HP:0010297)1.56479059
148Anomalous pulmonary venous return (HP:0010772)1.56379041
149Bladder diverticulum (HP:0000015)1.55054770
150Fibular hypoplasia (HP:0003038)1.54955914
151Supernumerary ribs (HP:0005815)1.54462591
152Short phalanx of the thumb (HP:0009660)1.54350280
153Neoplasm of the oral cavity (HP:0100649)1.51358988
154Hypoplasia of the uterus (HP:0000013)1.49923591
155Maternal diabetes (HP:0009800)1.49752450
156Renal hypoplasia (HP:0000089)1.49220582
157Postaxial hand polydactyly (HP:0001162)1.48241281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.85558413
2TYRO33.70554516
3ICK3.13719229
4NTRK22.79397922
5EPHB22.74393831
6NTRK32.72076112
7PRKD32.67878085
8MAPK152.62603621
9EPHA42.58127690
10MARK12.50658762
11SIK32.26112614
12MAPK132.18868298
13KSR12.14554039
14PDGFRA2.05359244
15NTRK12.01516947
16MAP3K41.87453665
17CDK121.83798954
18BRD41.72968775
19EPHA31.72845574
20PHKG11.67097160
21PHKG21.67097160
22MKNK11.56497121
23MKNK21.55587837
24CDC71.48353996
25SIK21.43795083
26WNK41.33903257
27WNK31.28100525
28MINK11.26352076
29PAK61.25604724
30DAPK21.23816633
31PINK11.23625178
32TNIK1.22379375
33CDK191.20002737
34BMPR1B1.18803726
35CDK71.15026568
36LATS11.11683690
37SGK21.11133745
38SGK4941.09644610
39SGK2231.09644610
40LMTK21.07998785
41EPHB11.07777771
42FGFR21.06303182
43ERBB21.05863489
44MOS1.05643746
45TSSK61.04309108
46STK391.03885068
47SIK11.02133492
48LATS21.01354184
49DYRK1B0.98960617
50DYRK20.97859102
51PNCK0.97463099
52MAP2K70.94633463
53BCKDK0.93665214
54UHMK10.89857392
55PLK20.89410663
56ERBB30.88340724
57CAMK1D0.86034983
58CDK30.84791288
59DYRK1A0.82153087
60PRKCG0.80347233
61CDC42BPA0.79976163
62MAP4K20.78459113
63BCR0.78196748
64WEE10.76841953
65PKN10.75181344
66ROCK20.73039913
67CSNK1A1L0.72919481
68CDK80.71266433
69NEK60.71085311
70MAP3K100.71064707
71CSNK1G20.70193900
72STK160.70032923
73PAK30.69683297
74PASK0.67899303
75PRKD20.66629356
76SRPK10.65281695
77CDK50.62708107
78ADRBK20.61482615
79SGK30.60635212
80CAMK1G0.59579086
81TRIM280.59454708
82PRKCZ0.58129966
83CDK180.57862092
84DYRK30.57830304
85VRK10.57698673
86FGFR10.56935276
87CAMKK10.56129643
88YES10.54484977
89CSNK1G30.53908923
90CAMK2A0.53546156
91DDR20.53216097
92DAPK10.53131984
93CCNB10.52744992
94AKT20.52510316
95CAMK40.50552349
96CDK150.50270611
97CDK10.50125044
98RPS6KA30.50075846
99GSK3B0.49917666
100CSNK1G10.49883260
101ATR0.49309992
102STK380.48926506
103FER0.47847307
104TRIB30.47462368
105STK110.47014154
106PRKCE0.46346450
107TESK10.46329896
108MAP2K40.46229055
109MTOR0.46200794
110CHEK10.46112852
111PRPF4B0.45483410
112ROCK10.44734871
113CAMK2B0.44587912
114PTK60.44396804
115AKT10.43886515
116CDK20.43400836
117CSNK1D0.42615328
118CDK11A0.42062498
119CDK140.41676770
120ERBB40.41249521
121SGK10.41148849
122NEK20.41047230
123PLK30.40436876
124CAMK2D0.40375294
125CSNK1E0.39725141
126MAPK100.39370134
127PRKDC0.38379609
128PDGFRB0.38027253
129MAPK80.37576819
130RIPK10.36991759
131CAMK10.36966562
132TNK20.36930832
133DMPK0.33768456
134CSNK1A10.33263295
135RPS6KA40.32640035
136PAK20.32516801
137PRKACB0.32191980
138WNK10.30820976
139PRKCH0.30317033
140PRKACA0.29356959
141TGFBR10.29339321
142NUAK10.29286575
143RPS6KA20.29185685
144INSRR0.28672640
145RPS6KA10.27698159

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.01753884
2Hedgehog signaling pathway_Homo sapiens_hsa043402.80589364
3Basal cell carcinoma_Homo sapiens_hsa052172.76630430
4Nicotine addiction_Homo sapiens_hsa050332.63479118
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.40350896
6* Axon guidance_Homo sapiens_hsa043602.37544646
7Notch signaling pathway_Homo sapiens_hsa043302.20319563
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18409223
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.07207125
10Glutamatergic synapse_Homo sapiens_hsa047241.92994603
11Fatty acid biosynthesis_Homo sapiens_hsa000611.88591134
12Lysine degradation_Homo sapiens_hsa003101.86412467
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84447315
14mRNA surveillance pathway_Homo sapiens_hsa030151.77462504
15Hippo signaling pathway_Homo sapiens_hsa043901.75655551
16Nitrogen metabolism_Homo sapiens_hsa009101.74620999
17Morphine addiction_Homo sapiens_hsa050321.73180866
18Circadian entrainment_Homo sapiens_hsa047131.70502564
19Olfactory transduction_Homo sapiens_hsa047401.69103430
20GABAergic synapse_Homo sapiens_hsa047271.68239040
21Amphetamine addiction_Homo sapiens_hsa050311.65410808
22Wnt signaling pathway_Homo sapiens_hsa043101.59508276
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58015799
24Renin secretion_Homo sapiens_hsa049241.56553479
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54105551
26Cardiac muscle contraction_Homo sapiens_hsa042601.52584955
27Dopaminergic synapse_Homo sapiens_hsa047281.49703681
28Cocaine addiction_Homo sapiens_hsa050301.48388563
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.46210806
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45256775
31Dorso-ventral axis formation_Homo sapiens_hsa043201.43050142
32Melanogenesis_Homo sapiens_hsa049161.42255768
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37521903
34Parkinsons disease_Homo sapiens_hsa050121.36694866
35Insulin secretion_Homo sapiens_hsa049111.30452693
36Sulfur relay system_Homo sapiens_hsa041221.28959610
37Fatty acid metabolism_Homo sapiens_hsa012121.27932138
38Ribosome_Homo sapiens_hsa030101.26997869
39Synaptic vesicle cycle_Homo sapiens_hsa047211.24994658
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.24049828
41Gap junction_Homo sapiens_hsa045401.22807373
42Long-term potentiation_Homo sapiens_hsa047201.21375381
43Oxidative phosphorylation_Homo sapiens_hsa001901.18367769
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14907770
45Propanoate metabolism_Homo sapiens_hsa006401.14122270
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13179850
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12962128
48Calcium signaling pathway_Homo sapiens_hsa040201.12506390
49cAMP signaling pathway_Homo sapiens_hsa040241.12322949
50Glioma_Homo sapiens_hsa052141.11829655
51Taste transduction_Homo sapiens_hsa047421.10532033
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10160379
53Oocyte meiosis_Homo sapiens_hsa041141.07213023
54Gastric acid secretion_Homo sapiens_hsa049711.03960143
55Cholinergic synapse_Homo sapiens_hsa047251.01893578
56ErbB signaling pathway_Homo sapiens_hsa040120.99064539
57Oxytocin signaling pathway_Homo sapiens_hsa049210.99039960
58Protein export_Homo sapiens_hsa030600.98931568
59Huntingtons disease_Homo sapiens_hsa050160.98513915
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97523367
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94009423
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93763111
63Salivary secretion_Homo sapiens_hsa049700.93652615
64TGF-beta signaling pathway_Homo sapiens_hsa043500.93581003
65Ovarian steroidogenesis_Homo sapiens_hsa049130.90748455
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89963324
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89812954
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89322901
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87429143
70Alzheimers disease_Homo sapiens_hsa050100.87088952
71Serotonergic synapse_Homo sapiens_hsa047260.86244812
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85334372
73MicroRNAs in cancer_Homo sapiens_hsa052060.84457289
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83677709
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83056583
76Spliceosome_Homo sapiens_hsa030400.82339741
77Cell cycle_Homo sapiens_hsa041100.79094757
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79024747
79Butanoate metabolism_Homo sapiens_hsa006500.78116811
80Tight junction_Homo sapiens_hsa045300.77921918
81Estrogen signaling pathway_Homo sapiens_hsa049150.76077519
82Fanconi anemia pathway_Homo sapiens_hsa034600.75335605
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.75210165
84GnRH signaling pathway_Homo sapiens_hsa049120.73664257
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72332465
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71146796
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71054738
88Choline metabolism in cancer_Homo sapiens_hsa052310.70936225
89Glucagon signaling pathway_Homo sapiens_hsa049220.70617098
90Endometrial cancer_Homo sapiens_hsa052130.69908260
91Long-term depression_Homo sapiens_hsa047300.69735761
92Arginine and proline metabolism_Homo sapiens_hsa003300.67393395
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67312935
94Peroxisome_Homo sapiens_hsa041460.67249902
95Dilated cardiomyopathy_Homo sapiens_hsa054140.65371291
96Ether lipid metabolism_Homo sapiens_hsa005650.65145627
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65026858
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63742606
99Colorectal cancer_Homo sapiens_hsa052100.63343042
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59032947
101Type II diabetes mellitus_Homo sapiens_hsa049300.58760064
102Basal transcription factors_Homo sapiens_hsa030220.57494895
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.56947371
104Thyroid hormone synthesis_Homo sapiens_hsa049180.56872475
105Bile secretion_Homo sapiens_hsa049760.55912778
106Linoleic acid metabolism_Homo sapiens_hsa005910.55340720
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54456890
108RNA degradation_Homo sapiens_hsa030180.53369623
109Alcoholism_Homo sapiens_hsa050340.53274685
110beta-Alanine metabolism_Homo sapiens_hsa004100.53125061
111Phototransduction_Homo sapiens_hsa047440.52613232
112Fatty acid degradation_Homo sapiens_hsa000710.52575592
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50956623
114Melanoma_Homo sapiens_hsa052180.50234447
115PPAR signaling pathway_Homo sapiens_hsa033200.50199244
116Rap1 signaling pathway_Homo sapiens_hsa040150.49173359
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48621370
118mTOR signaling pathway_Homo sapiens_hsa041500.47843594
119Prion diseases_Homo sapiens_hsa050200.47491093
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.47483331
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.47318860
122Ras signaling pathway_Homo sapiens_hsa040140.46551756
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.46049636
124Pathways in cancer_Homo sapiens_hsa052000.45851096
125Protein digestion and absorption_Homo sapiens_hsa049740.45403955
126MAPK signaling pathway_Homo sapiens_hsa040100.43804117
127ECM-receptor interaction_Homo sapiens_hsa045120.43736949
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43189260
129Adherens junction_Homo sapiens_hsa045200.40416960
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39592773
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39182407
132Prostate cancer_Homo sapiens_hsa052150.37443461
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31793561

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