SEMA6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.47517881
2axon ensheathment in central nervous system (GO:0032291)9.47517881
3fatty acid elongation (GO:0030497)7.30040163
4myelination (GO:0042552)6.92018212
5axon ensheathment (GO:0008366)6.91045972
6ensheathment of neurons (GO:0007272)6.91045972
7regulation of gene silencing by RNA (GO:0060966)5.68735749
8regulation of posttranscriptional gene silencing (GO:0060147)5.68735749
9regulation of gene silencing by miRNA (GO:0060964)5.68735749
10negative regulation of neurotransmitter secretion (GO:0046929)5.53383538
11cholesterol biosynthetic process (GO:0006695)5.46312132
12long-chain fatty acid biosynthetic process (GO:0042759)5.43323463
13paraxial mesoderm development (GO:0048339)4.83881047
14sterol biosynthetic process (GO:0016126)4.75441572
15glycerophospholipid catabolic process (GO:0046475)4.68191099
16presynaptic membrane assembly (GO:0097105)4.67062166
17substantia nigra development (GO:0021762)4.58007857
18regulation of collateral sprouting (GO:0048670)4.56040451
19oligodendrocyte differentiation (GO:0048709)4.53183533
20pre-miRNA processing (GO:0031054)4.52347901
21presynaptic membrane organization (GO:0097090)4.44391711
22negative regulation of neurotransmitter transport (GO:0051589)4.39526958
23virion attachment to host cell (GO:0019062)4.38502027
24adhesion of symbiont to host cell (GO:0044650)4.38502027
25negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.36995739
26myelination in peripheral nervous system (GO:0022011)4.36383357
27peripheral nervous system axon ensheathment (GO:0032292)4.36383357
28photoreceptor cell differentiation (GO:0046530)4.25192208
29eye photoreceptor cell differentiation (GO:0001754)4.25192208
30peptidyl-tyrosine autophosphorylation (GO:0038083)4.09593771
31transmission of nerve impulse (GO:0019226)4.08489745
32isoprenoid biosynthetic process (GO:0008299)4.06040283
33negative regulation of translation, ncRNA-mediated (GO:0040033)4.05488776
34regulation of translation, ncRNA-mediated (GO:0045974)4.05488776
35negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.05488776
36astrocyte development (GO:0014002)4.01294647
37response to redox state (GO:0051775)3.93919222
38asymmetric protein localization (GO:0008105)3.90052667
39establishment of integrated proviral latency (GO:0075713)3.89990845
40L-amino acid import (GO:0043092)3.89547841
41neuron cell-cell adhesion (GO:0007158)3.82345704
42lung-associated mesenchyme development (GO:0060484)3.82157952
43apical protein localization (GO:0045176)3.81467682
44response to hepatocyte growth factor (GO:0035728)3.80502526
45cellular response to hepatocyte growth factor stimulus (GO:0035729)3.80502526
46negative regulation of axon extension (GO:0030517)3.75816174
47creatine metabolic process (GO:0006600)3.69472766
48L-serine metabolic process (GO:0006563)3.69388917
49Rap protein signal transduction (GO:0032486)3.66349295
50neuronal ion channel clustering (GO:0045161)3.64527194
51negative regulation of axonogenesis (GO:0050771)3.64207039
52negative regulation of protein localization to cell surface (GO:2000009)3.64100260
53positive regulation of SMAD protein import into nucleus (GO:0060391)3.62733052
54regulation of cell fate specification (GO:0042659)3.61969370
55long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.61206596
56cellular response to epinephrine stimulus (GO:0071872)3.60240825
57import into cell (GO:0098657)3.58053068
58limb bud formation (GO:0060174)3.55098075
59cerebral cortex radially oriented cell migration (GO:0021799)3.53559379
60myelin maintenance (GO:0043217)3.51744804
61positive regulation of action potential (GO:0045760)3.48646972
62heterochromatin organization (GO:0070828)3.44204930
63notochord development (GO:0030903)3.40297090
64establishment of mitochondrion localization (GO:0051654)3.32221215
65adhesion of symbiont to host (GO:0044406)3.31824742
66long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.26644403
67positive regulation of actin filament depolymerization (GO:0030836)3.25818724
68chromatin remodeling at centromere (GO:0031055)3.21188478
69neural nucleus development (GO:0048857)3.16360241
70response to epinephrine (GO:0071871)3.12995612
71nucleotide transmembrane transport (GO:1901679)3.12387704
72response to lipoprotein particle (GO:0055094)3.12325598
73anterior/posterior axis specification, embryo (GO:0008595)3.10253565
74fatty-acyl-CoA biosynthetic process (GO:0046949)3.09076782
75positive regulation of oligodendrocyte differentiation (GO:0048714)3.08775226
76peripheral nervous system development (GO:0007422)3.06690429
77protein palmitoylation (GO:0018345)3.06396481
78protein complex localization (GO:0031503)3.05671173
79amino acid import (GO:0043090)3.05663454
80amyloid precursor protein metabolic process (GO:0042982)3.05263625
81cerebellar granule cell differentiation (GO:0021707)3.04967328
82protein localization to kinetochore (GO:0034501)3.04124668
83cell fate commitment involved in formation of primary germ layer (GO:0060795)3.02039235
84regulation of gene silencing (GO:0060968)3.01318933
85convergent extension (GO:0060026)3.00586493
86CENP-A containing nucleosome assembly (GO:0034080)3.00293772
87postsynaptic membrane organization (GO:0001941)2.99155113
88membrane assembly (GO:0071709)2.98763094
89negative regulation of axon extension involved in axon guidance (GO:0048843)2.90581339
90dorsal/ventral axis specification (GO:0009950)2.88761885
91regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.88054043
92lateral sprouting from an epithelium (GO:0060601)2.87780671
93dendritic spine morphogenesis (GO:0060997)2.87477260
94positive regulation of neurological system process (GO:0031646)2.86041230
95mesenchymal to epithelial transition (GO:0060231)2.85115106
96negative regulation of gene silencing (GO:0060969)2.84765179
97magnesium ion transport (GO:0015693)2.84496836
98vocalization behavior (GO:0071625)2.84440879
99neurotransmitter catabolic process (GO:0042135)2.83810282
100fatty-acyl-CoA metabolic process (GO:0035337)2.79966590
101otic vesicle formation (GO:0030916)2.79245327
102melanin biosynthetic process (GO:0042438)2.79055797
103activated T cell proliferation (GO:0050798)2.78530029
104regulation of cell fate commitment (GO:0010453)2.76865097
105histone exchange (GO:0043486)2.76851626
106pyrimidine nucleobase catabolic process (GO:0006208)2.74823178
107kidney morphogenesis (GO:0060993)2.74373529
108adult walking behavior (GO:0007628)2.73952864
109response to methylmercury (GO:0051597)2.73280543
110ear development (GO:0043583)2.72513462
111cellular response to catecholamine stimulus (GO:0071870)2.72138431
112cellular response to monoamine stimulus (GO:0071868)2.72138431
113neuron recognition (GO:0008038)2.71960535
114establishment of viral latency (GO:0019043)2.70095962
115neuron remodeling (GO:0016322)2.69822925
116leukocyte migration involved in inflammatory response (GO:0002523)2.69681780
117negative regulation of axon guidance (GO:1902668)2.69398573
118DNA damage response, detection of DNA damage (GO:0042769)2.68195663
119regulation of histone H3-K9 methylation (GO:0051570)2.67450968
120regulation of SMAD protein import into nucleus (GO:0060390)2.66637107
121regulation of non-canonical Wnt signaling pathway (GO:2000050)2.64708623
122DNA replication-independent nucleosome organization (GO:0034724)2.63824591
123DNA replication-independent nucleosome assembly (GO:0006336)2.63824591
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.63022647
125establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.62329492
126glial cell differentiation (GO:0010001)2.62223421
127secondary metabolite biosynthetic process (GO:0044550)2.61585070
128nerve growth factor signaling pathway (GO:0038180)2.60614843
129cranial nerve development (GO:0021545)2.60526070
130regulation of helicase activity (GO:0051095)2.58750519
131axonal fasciculation (GO:0007413)2.57256172
132very long-chain fatty acid metabolic process (GO:0000038)2.57221883
133negative regulation of JUN kinase activity (GO:0043508)2.57007527
134phosphatidylinositol 3-kinase signaling (GO:0014065)2.55697182
135histone H2B ubiquitination (GO:0033523)2.55437254
136enteric nervous system development (GO:0048484)2.55428823
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54914149
138regulation of mitotic spindle checkpoint (GO:1903504)2.54914149
139glial cell development (GO:0021782)2.54669582
140axon development (GO:0061564)2.53374310
141Golgi to plasma membrane protein transport (GO:0043001)2.53330165
142ATP-dependent chromatin remodeling (GO:0043044)2.53286665
143lysine catabolic process (GO:0006554)2.53272486
144lysine metabolic process (GO:0006553)2.53272486
145digestive tract morphogenesis (GO:0048546)2.52769079
146atrial cardiac muscle cell action potential (GO:0086014)2.52741409
147positive regulation of interleukin-17 production (GO:0032740)2.52216274
148negative regulation of sister chromatid segregation (GO:0033046)2.51864400
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.51864400
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.51864400
151negative regulation of mitotic sister chromatid segregation (GO:0033048)2.51864400
152negative regulation of mitotic sister chromatid separation (GO:2000816)2.51864400
153negative regulation of myoblast differentiation (GO:0045662)2.51851489
154somatic stem cell division (GO:0048103)2.51713800
155regulation of somitogenesis (GO:0014807)2.51268299
156glycosylceramide metabolic process (GO:0006677)2.50225109
157response to monoamine (GO:0071867)2.49614101
158response to catecholamine (GO:0071869)2.49614101
159negative regulation of chromosome segregation (GO:0051985)2.48341527
160negative regulation of androgen receptor signaling pathway (GO:0060766)2.47484643
161peptidyl-cysteine modification (GO:0018198)2.47127393
162regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.45863851
163mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.44052979
164cellular response to cholesterol (GO:0071397)2.40526977
165neuronal stem cell maintenance (GO:0097150)2.39820586
166negative regulation of histone methylation (GO:0031061)2.39546998
167organ growth (GO:0035265)2.39202059
168positive regulation of catenin import into nucleus (GO:0035413)2.36820116
169melanin metabolic process (GO:0006582)2.36237649
170histone arginine methylation (GO:0034969)2.35650959
171planar cell polarity pathway involved in neural tube closure (GO:0090179)2.35240390
172negative regulation of telomerase activity (GO:0051974)2.34329769
173spindle checkpoint (GO:0031577)2.33221293
174regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.32377809
175mitotic metaphase plate congression (GO:0007080)2.31982782
176establishment of monopolar cell polarity (GO:0061162)2.31955932
177establishment or maintenance of monopolar cell polarity (GO:0061339)2.31955932
178inner ear receptor cell development (GO:0060119)2.31658404
179regulation of development, heterochronic (GO:0040034)2.30523958
180regulation of nuclear cell cycle DNA replication (GO:0033262)2.30404177
181single strand break repair (GO:0000012)2.29162591
182regulation of chromatin silencing (GO:0031935)2.28559193
183mitotic spindle checkpoint (GO:0071174)2.27359811
184somatic stem cell maintenance (GO:0035019)2.26597254
185G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.24583770
186telomere maintenance via telomerase (GO:0007004)2.24526570
187female gonad development (GO:0008585)2.24028554
188cell surface receptor signaling pathway involved in heart development (GO:0061311)2.23971194
189stem cell division (GO:0017145)2.23937677
190negative regulation of cell fate commitment (GO:0010454)2.23413171
191serine family amino acid biosynthetic process (GO:0009070)2.22930207
192establishment of protein localization to mitochondrial membrane (GO:0090151)2.22890802
193generation of neurons (GO:0048699)2.22713727
194IMP biosynthetic process (GO:0006188)2.21919628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.56088448
2E2F7_22180533_ChIP-Seq_HELA_Human3.44640315
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.04743664
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93339473
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.83688262
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.73236446
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.68572639
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.68572639
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.68572639
10SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.64526119
11TAF15_26573619_Chip-Seq_HEK293_Human2.55498443
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52416476
13* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46178197
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.39946110
15* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38156902
16EZH2_22144423_ChIP-Seq_EOC_Human2.33951768
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.30688330
18* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26213552
19* SOX2_16153702_ChIP-ChIP_HESCs_Human2.22096247
20* EED_16625203_ChIP-ChIP_MESCs_Mouse2.16646759
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.14547578
22AR_21572438_ChIP-Seq_LNCaP_Human2.12007287
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11594875
24* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11433171
25* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11433171
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.06056524
27WT1_19549856_ChIP-ChIP_CCG9911_Human2.03873112
28* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01613418
29* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01177118
30* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.98279456
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97447686
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97192941
33NANOG_16153702_ChIP-ChIP_HESCs_Human1.97181423
34* EZH2_27294783_Chip-Seq_ESCs_Mouse1.94283521
35* CBX2_27304074_Chip-Seq_ESCs_Mouse1.93814709
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93563496
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92779648
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.91918854
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91451996
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89391670
41* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88411641
42* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87071887
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.85049248
44* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84194191
45* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83456634
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81474627
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81319344
48ER_23166858_ChIP-Seq_MCF-7_Human1.80678419
49VDR_22108803_ChIP-Seq_LS180_Human1.78404249
50* RNF2_27304074_Chip-Seq_ESCs_Mouse1.76358002
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75654740
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.73588874
53* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72894882
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.72558681
55DROSHA_22980978_ChIP-Seq_HELA_Human1.70567749
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67952362
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66579998
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65931894
59* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65692188
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65143953
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59121621
62SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.57943659
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.56488009
64POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.55613640
65* PIAS1_25552417_ChIP-Seq_VCAP_Human1.52804836
66* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52663172
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52508411
68* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52374338
69* EWS_26573619_Chip-Seq_HEK293_Human1.50578150
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46409243
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46181322
72* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.45903659
73* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.45708665
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45350282
75* P300_19829295_ChIP-Seq_ESCs_Human1.45187802
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44662255
77ZNF274_21170338_ChIP-Seq_K562_Hela1.43578849
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42922715
79* FUS_26573619_Chip-Seq_HEK293_Human1.42017655
80NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.41736538
81* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40952132
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.38704186
83* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.38590256
84RNF2_27304074_Chip-Seq_NSC_Mouse1.38080297
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37401284
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36716724
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.35662121
88* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34251463
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31384588
90* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31093872
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28342886
92* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27762725
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26525315
94TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.25789920
95* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24543743
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24194831
97TRIM28_21343339_ChIP-Seq_HEK293_Human1.22176310
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21696997
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21421174
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20760346
101SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.20155554
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19337407
103ISL1_27105846_Chip-Seq_CPCs_Mouse1.18770876
104AR_21909140_ChIP-Seq_LNCAP_Human1.18732853
105* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17577116
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17448697
107TP63_19390658_ChIP-ChIP_HaCaT_Human1.17331587
108* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16587904
109STAT3_23295773_ChIP-Seq_U87_Human1.16549314
110* REST_21632747_ChIP-Seq_MESCs_Mouse1.15859953
111PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.15521733
112* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14855909
113POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13823287
114* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13251586
115SMAD4_21799915_ChIP-Seq_A2780_Human1.13218942
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11571797
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11311713
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.10351018
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10178332
120NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10178332
121* RING1B_27294783_Chip-Seq_NPCs_Mouse1.09929432
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09488141
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07463919
124* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05907722
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.05673966
126EST1_17652178_ChIP-ChIP_JURKAT_Human1.05381997
127* SMAD3_21741376_ChIP-Seq_ESCs_Human1.05208170
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05133553
129* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04077821
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.03934989
131* RING1B_27294783_Chip-Seq_ESCs_Mouse1.03622376
132* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02426228
133TCF4_23295773_ChIP-Seq_U87_Human1.02089876
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02021887
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01759093
136E2F1_21310950_ChIP-Seq_MCF-7_Human1.01209314
137* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01002145
138MYC_18940864_ChIP-ChIP_HL60_Human1.00342690
139NANOG_21062744_ChIP-ChIP_HESCs_Human1.00041615
140IGF1R_20145208_ChIP-Seq_DFB_Human0.99955651
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99541148
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99236335
143* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98667330
144SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98435462
145P300_18555785_Chip-Seq_ESCs_Mouse0.97649803
146NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97624991
147* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97588077
148* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97380721
149* RUNX2_22187159_ChIP-Seq_PCA_Human0.97264719
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97245967
151SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97186835
152NANOG_16518401_ChIP-PET_MESCs_Mouse0.96966897
153POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96899937
154AHR_22903824_ChIP-Seq_MCF-7_Human0.96651965
155* SOX9_26525672_Chip-Seq_HEART_Mouse0.96598589
156STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96591203
157GATA1_26923725_Chip-Seq_HPCs_Mouse0.96466153
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96421941
159NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96277630
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96058032
161NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95988593
162PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95827303
163SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95581550
164* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95226459
165RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94773608
166IRF1_19129219_ChIP-ChIP_H3396_Human0.94432428
167RARB_27405468_Chip-Seq_BRAIN_Mouse0.94308652
168* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94083344
169* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92879602
170* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92879602
171ARNT_22903824_ChIP-Seq_MCF-7_Human0.92771659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.84142091
2MP0003880_abnormal_central_pattern3.75950908
3MP0003690_abnormal_glial_cell3.18169450
4MP0004270_analgesia3.10700085
5MP0003941_abnormal_skin_development2.82535704
6MP0004742_abnormal_vestibular_system2.80327030
7MP0000778_abnormal_nervous_system2.74734442
8MP0003890_abnormal_embryonic-extraembry2.73150448
9MP0005171_absent_coat_pigmentation2.70983927
10MP0004885_abnormal_endolymph2.62891841
11MP0001529_abnormal_vocalization2.61370754
12MP0003950_abnormal_plasma_membrane2.55153699
13MP0001485_abnormal_pinna_reflex2.54536693
14MP0006292_abnormal_olfactory_placode2.54241630
15MP0003878_abnormal_ear_physiology2.45829745
16MP0005377_hearing/vestibular/ear_phenot2.45829745
17MP0001486_abnormal_startle_reflex2.44327681
18MP0005409_darkened_coat_color2.43290925
19MP0002254_reproductive_system_inflammat2.40392398
20MP0003136_yellow_coat_color2.35202331
21MP0000462_abnormal_digestive_system2.32895263
22MP0001905_abnormal_dopamine_level2.30442180
23MP0002272_abnormal_nervous_system2.26776746
24MP0001293_anophthalmia2.24492536
25MP0003634_abnormal_glial_cell2.17684072
26MP0003329_amyloid_beta_deposits2.02179889
27MP0002064_seizures1.96334907
28MP0003567_abnormal_fetal_cardiomyocyte1.86931697
29MP0009672_abnormal_birth_weight1.85091865
30MP0010030_abnormal_orbit_morphology1.82795290
31MP0003693_abnormal_embryo_hatching1.82607176
32MP0004142_abnormal_muscle_tone1.79959662
33MP0004859_abnormal_synaptic_plasticity1.79091452
34MP0003119_abnormal_digestive_system1.78105885
35MP0003632_abnormal_nervous_system1.75884067
36MP0004134_abnormal_chest_morphology1.75432251
37MP0004957_abnormal_blastocyst_morpholog1.75238397
38MP0002697_abnormal_eye_size1.71799553
39MP0000566_synostosis1.70828368
40MP0008877_abnormal_DNA_methylation1.70460803
41MP0005451_abnormal_body_composition1.67978677
42MP0000372_irregular_coat_pigmentation1.66892521
43MP0003121_genomic_imprinting1.64571516
44MP0002734_abnormal_mechanical_nocicepti1.63602472
45MP0009745_abnormal_behavioral_response1.61693282
46MP0009046_muscle_twitch1.61341176
47MP0005423_abnormal_somatic_nervous1.60045178
48MP0003635_abnormal_synaptic_transmissio1.59038812
49MP0000383_abnormal_hair_follicle1.58938625
50MP0002229_neurodegeneration1.55700098
51MP0005623_abnormal_meninges_morphology1.52738874
52MP0003937_abnormal_limbs/digits/tail_de1.49382829
53MP0005551_abnormal_eye_electrophysiolog1.49245701
54MP0002882_abnormal_neuron_morphology1.49204591
55MP0000955_abnormal_spinal_cord1.49169845
56MP0003111_abnormal_nucleus_morphology1.48480521
57MP0008932_abnormal_embryonic_tissue1.46954536
58MP0003123_paternal_imprinting1.46614480
59MP0001299_abnormal_eye_distance/1.44792223
60MP0002653_abnormal_ependyma_morphology1.44170587
61MP0001440_abnormal_grooming_behavior1.42734397
62MP0010678_abnormal_skin_adnexa1.41529462
63MP0003938_abnormal_ear_development1.40023583
64MP0002752_abnormal_somatic_nervous1.37201411
65MP0000579_abnormal_nail_morphology1.36396420
66MP0001286_abnormal_eye_development1.36178218
67MP0004272_abnormal_basement_membrane1.32562816
68MP0001661_extended_life_span1.32390829
69MP0010094_abnormal_chromosome_stability1.32090915
70MP0003718_maternal_effect1.30571452
71MP0002736_abnormal_nociception_after1.29858357
72MP0001963_abnormal_hearing_physiology1.29331284
73MP0002572_abnormal_emotion/affect_behav1.28682598
74MP0000049_abnormal_middle_ear1.28390233
75MP0008058_abnormal_DNA_repair1.27187458
76MP0002084_abnormal_developmental_patter1.23003382
77MP0002085_abnormal_embryonic_tissue1.21906435
78MP0004381_abnormal_hair_follicle1.20467529
79MP0002067_abnormal_sensory_capabilities1.19541270
80MP0002066_abnormal_motor_capabilities/c1.18604014
81MP0003283_abnormal_digestive_organ1.17524041
82MP0009703_decreased_birth_body1.16663444
83MP0009250_abnormal_appendicular_skeleto1.16140725
84MP0005410_abnormal_fertilization1.16134827
85MP0003787_abnormal_imprinting1.14744311
86MP0004147_increased_porphyrin_level1.14230436
87MP0005195_abnormal_posterior_eye1.13642134
88MP0000762_abnormal_tongue_morphology1.13429399
89MP0001346_abnormal_lacrimal_gland1.13315418
90MP0000026_abnormal_inner_ear1.13307436
91MP0002063_abnormal_learning/memory/cond1.12663476
92MP0003385_abnormal_body_wall1.12520166
93MP0000647_abnormal_sebaceous_gland1.11718622
94MP0005386_behavior/neurological_phenoty1.11624182
95MP0004924_abnormal_behavior1.11624182
96MP0002090_abnormal_vision1.10352895
97MP0003077_abnormal_cell_cycle1.09859978
98MP0002938_white_spotting1.09144382
99MP0005187_abnormal_penis_morphology1.07680614
100MP0000537_abnormal_urethra_morphology1.06406994
101MP0002111_abnormal_tail_morphology1.05956032
102MP0006072_abnormal_retinal_apoptosis1.05624390
103MP0004145_abnormal_muscle_electrophysio1.04759493
104MP0000428_abnormal_craniofacial_morphol1.01474127
105MP0002092_abnormal_eye_morphology0.98309799
106* MP0002152_abnormal_brain_morphology0.98084834
107MP0005253_abnormal_eye_physiology0.97505008
108MP0001324_abnormal_eye_pigmentation0.97497053
109MP0002822_catalepsy0.96939271
110MP0003631_nervous_system_phenotype0.96832286
111MP0001730_embryonic_growth_arrest0.95022358
112MP0005394_taste/olfaction_phenotype0.95019416
113MP0005499_abnormal_olfactory_system0.95019416
114MP0002184_abnormal_innervation0.94838492
115MP0004133_heterotaxia0.94564385
116MP0002295_abnormal_pulmonary_circulatio0.94375549
117MP0000432_abnormal_head_morphology0.94150666
118MP0005380_embryogenesis_phenotype0.92119170
119MP0001672_abnormal_embryogenesis/_devel0.92119170
120MP0008569_lethality_at_weaning0.91659498
121MP0001177_atelectasis0.88815407
122MP0005257_abnormal_intraocular_pressure0.87947756
123MP0002733_abnormal_thermal_nociception0.87630381
124MP0003861_abnormal_nervous_system0.87170619
125MP0004197_abnormal_fetal_growth/weight/0.86383853
126MP0005391_vision/eye_phenotype0.86298787
127MP0000467_abnormal_esophagus_morphology0.85830925
128MP0002638_abnormal_pupillary_reflex0.85785045
129MP0003942_abnormal_urinary_system0.85250832
130MP0009379_abnormal_foot_pigmentation0.85218429
131MP0003935_abnormal_craniofacial_develop0.85134214
132MP0001970_abnormal_pain_threshold0.84645286
133MP0003315_abnormal_perineum_morphology0.84254576
134MP0001727_abnormal_embryo_implantation0.83650795
135MP0002102_abnormal_ear_morphology0.82453324
136MP0001968_abnormal_touch/_nociception0.80221534
137MP0001984_abnormal_olfaction0.79919398
138MP0008438_abnormal_cutaneous_collagen0.79653770
139MP0002081_perinatal_lethality0.79569116
140MP0003137_abnormal_impulse_conducting0.79526341
141MP0005248_abnormal_Harderian_gland0.78810606
142MP0003122_maternal_imprinting0.78783674
143MP0000604_amyloidosis0.78620925
144MP0001697_abnormal_embryo_size0.78178684
145MP0002557_abnormal_social/conspecific_i0.76448733
146MP0003984_embryonic_growth_retardation0.75925545
147MP0008057_abnormal_DNA_replication0.75086773
148MP0005408_hypopigmentation0.74891983
149MP0000747_muscle_weakness0.74396579
150MP0000631_abnormal_neuroendocrine_gland0.74380204
151MP0003755_abnormal_palate_morphology0.72943628
152MP0002108_abnormal_muscle_morphology0.69625166
153MP0002735_abnormal_chemical_nociception0.67729456
154MP0001340_abnormal_eyelid_morphology0.66571477
155MP0006276_abnormal_autonomic_nervous0.65410152
156MP0001188_hyperpigmentation0.65092852
157MP0001851_eye_inflammation0.64095156
158MP0001502_abnormal_circadian_rhythm0.64015762
159MP0002751_abnormal_autonomic_nervous0.63801022
160MP0004185_abnormal_adipocyte_glucose0.62089091
161MP0002233_abnormal_nose_morphology0.62012583

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.35402714
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.35402714
3Sensory axonal neuropathy (HP:0003390)5.98263583
4Parakeratosis (HP:0001036)5.17913980
5Neurofibrillary tangles (HP:0002185)5.00422261
6Abnormality of the corticospinal tract (HP:0002492)4.78556963
7Hepatoblastoma (HP:0002884)3.91976686
8Abnormality of the labia minora (HP:0012880)3.80952951
9Peripheral hypomyelination (HP:0007182)3.76959320
10Akinesia (HP:0002304)3.75651658
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.61103449
12Colon cancer (HP:0003003)3.55289622
13Cerebral hypomyelination (HP:0006808)3.51089116
14Cerebral inclusion bodies (HP:0100314)3.41577016
15Abnormality of glycolysis (HP:0004366)3.34450495
16Increased serum pyruvate (HP:0003542)3.34450495
17Spastic gait (HP:0002064)3.27822975
18Hypoplastic pelvis (HP:0008839)3.17267044
19Alacrima (HP:0000522)3.13690913
20Bilateral microphthalmos (HP:0007633)3.11284879
21Intention tremor (HP:0002080)2.94932755
22Choanal stenosis (HP:0000452)2.87138992
23Small epiphyses (HP:0010585)2.85438063
24Onion bulb formation (HP:0003383)2.83012471
25Premature skin wrinkling (HP:0100678)2.81432220
26Cortical dysplasia (HP:0002539)2.80209304
27Anteriorly placed anus (HP:0001545)2.79153659
28Cupped ear (HP:0000378)2.76645260
29Maternal diabetes (HP:0009800)2.65616636
30Abnormal lung lobation (HP:0002101)2.65324354
31Anophthalmia (HP:0000528)2.63746977
32Congenital ichthyosiform erythroderma (HP:0007431)2.63303429
33Termporal pattern (HP:0011008)2.62745472
34Insidious onset (HP:0003587)2.62745472
35Dysmetria (HP:0001310)2.61427196
36Abnormal auditory evoked potentials (HP:0006958)2.61120534
37Leukodystrophy (HP:0002415)2.60963217
38Anomalous pulmonary venous return (HP:0010772)2.60747661
39Atonic seizures (HP:0010819)2.59326455
40Supranuclear gaze palsy (HP:0000605)2.55466926
41Retinal dysplasia (HP:0007973)2.54538100
42Absent septum pellucidum (HP:0001331)2.53655558
43Abnormality of the parathyroid morphology (HP:0011766)2.53393608
44Decreased lacrimation (HP:0000633)2.52535823
45Spastic paraparesis (HP:0002313)2.51441986
46Spastic diplegia (HP:0001264)2.51044981
47Coronal craniosynostosis (HP:0004440)2.48699695
48Partial agenesis of the corpus callosum (HP:0001338)2.48494598
49Aplasia/Hypoplasia of the sternum (HP:0006714)2.47237745
50Adrenal hypoplasia (HP:0000835)2.45154572
51Slow saccadic eye movements (HP:0000514)2.45059052
52Optic nerve hypoplasia (HP:0000609)2.37432867
53Increased circulating renin level (HP:0000848)2.37183687
54Cutaneous syndactyly (HP:0012725)2.36633690
55Abnormality of the pulmonary veins (HP:0011718)2.36055700
56Myelomeningocele (HP:0002475)2.35813786
57Scanning speech (HP:0002168)2.35752075
58Bronchomalacia (HP:0002780)2.35330201
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.33041279
60Chin dimple (HP:0010751)2.32894622
61Bifid tongue (HP:0010297)2.31812965
62Gastrointestinal atresia (HP:0002589)2.31770154
63Cutaneous finger syndactyly (HP:0010554)2.31255855
64Humeroradial synostosis (HP:0003041)2.30743114
65Synostosis involving the elbow (HP:0003938)2.30743114
66Nephroblastoma (Wilms tumor) (HP:0002667)2.29362691
67Partial duplication of thumb phalanx (HP:0009944)2.26218019
68Stenosis of the external auditory canal (HP:0000402)2.25819186
69Cerebral hemorrhage (HP:0001342)2.25438213
70Breast aplasia (HP:0100783)2.25153568
71Intestinal atresia (HP:0011100)2.24509052
72Split foot (HP:0001839)2.23811248
73Aqueductal stenosis (HP:0002410)2.23268760
74Thickened helices (HP:0000391)2.22889946
75Septo-optic dysplasia (HP:0100842)2.22383415
76Hyperglycinemia (HP:0002154)2.20983780
77Absent eyebrow (HP:0002223)2.20165387
78Esophageal atresia (HP:0002032)2.20057480
79Abnormality of the phalanges of the 2nd finger (HP:0009541)2.17333123
80Abnormality of the septum pellucidum (HP:0007375)2.17214863
81White forelock (HP:0002211)2.15417818
82Morphological abnormality of the inner ear (HP:0011390)2.14372518
83Fetal akinesia sequence (HP:0001989)2.12559657
84Hyperglycinuria (HP:0003108)2.12524647
85Embryonal renal neoplasm (HP:0011794)2.11361439
86Stridor (HP:0010307)2.09392871
87Aplasia/Hypoplasia of the breasts (HP:0010311)2.09384686
88Patchy hypopigmentation of hair (HP:0011365)2.08087952
89Hypomagnesemia (HP:0002917)2.06321050
90Infantile muscular hypotonia (HP:0008947)2.05945356
91Abnormal number of incisors (HP:0011064)2.05505589
92Renal Fanconi syndrome (HP:0001994)2.04698025
93Relative macrocephaly (HP:0004482)2.04650479
94Birth length less than 3rd percentile (HP:0003561)2.02804894
95Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.01744113
96Renal hypoplasia (HP:0000089)1.98822852
97Meningocele (HP:0002435)1.97954300
98Aplasia involving bones of the upper limbs (HP:0009823)1.97842635
99Aplasia of the phalanges of the hand (HP:0009802)1.97842635
100Aplasia involving bones of the extremities (HP:0009825)1.97842635
101Turricephaly (HP:0000262)1.97037958
102Hemivertebrae (HP:0002937)1.96741890
103Autoamputation (HP:0001218)1.96451372
104Preaxial foot polydactyly (HP:0001841)1.94813513
105Barrel-shaped chest (HP:0001552)1.94401348
106Short hallux (HP:0010109)1.93022305
107Medulloblastoma (HP:0002885)1.91900059
108Steppage gait (HP:0003376)1.91036144
109CNS hypomyelination (HP:0003429)1.90679178
110Trigonocephaly (HP:0000243)1.89841742
111Omphalocele (HP:0001539)1.89747176
112Facial cleft (HP:0002006)1.89742034
113Neoplasm of the adrenal cortex (HP:0100641)1.89392947
114Delayed epiphyseal ossification (HP:0002663)1.89365139
115Ependymoma (HP:0002888)1.89321489
116Hypoplasia of the iris (HP:0007676)1.87526893
117Bowel incontinence (HP:0002607)1.87244510
118Diminished movement (HP:0002374)1.86501134
119Abnormal hair whorl (HP:0010721)1.85974915
120Vaginal atresia (HP:0000148)1.85768200
121Abnormality of the middle phalanges of the toes (HP:0010183)1.85544213
122Abnormality of serine family amino acid metabolism (HP:0010894)1.85379213
123Abnormality of glycine metabolism (HP:0010895)1.85379213
124High anterior hairline (HP:0009890)1.84949187
125Aplasia/Hypoplasia of the hallux (HP:0008362)1.84830152
126Midline defect of the nose (HP:0004122)1.84649965
127Epiphyseal dysplasia (HP:0002656)1.84592928
128Absent radius (HP:0003974)1.84510368
129Meckel diverticulum (HP:0002245)1.84271517
130Supernumerary spleens (HP:0009799)1.84135189
131Abnormality of the vitreous humor (HP:0004327)1.83814611
132Megalencephaly (HP:0001355)1.83598041
133Partial duplication of the phalanx of hand (HP:0009999)1.83146160
134Labial hypoplasia (HP:0000066)1.82290003
135Hypoplastic female external genitalia (HP:0012815)1.82053614
136Mixed hearing impairment (HP:0000410)1.81594219
137Methylmalonic acidemia (HP:0002912)1.81340580
138Aplasia involving forearm bones (HP:0009822)1.81036215
139Absent forearm bone (HP:0003953)1.81036215
140Abnormality of the lacrimal duct (HP:0011481)1.80467740
141Abolished electroretinogram (ERG) (HP:0000550)1.79437348
142Conical tooth (HP:0000698)1.78716681
143Abnormality of incisor morphology (HP:0011063)1.76686232
144Neoplasm of the oral cavity (HP:0100649)1.76084158
145Clumsiness (HP:0002312)1.75925364
146Lower limb muscle weakness (HP:0007340)1.75763038
147Pheochromocytoma (HP:0002666)1.75369462
148Genital tract atresia (HP:0001827)1.74650396
149Impulsivity (HP:0100710)1.74607828
150Increased nuchal translucency (HP:0010880)1.73523879
151Broad thumb (HP:0011304)1.73109531
152Morphological abnormality of the middle ear (HP:0008609)1.72892566
153Abnormality of homocysteine metabolism (HP:0010919)1.72869330
154Homocystinuria (HP:0002156)1.72869330
155Abnormality of the ileum (HP:0001549)1.72286455
156Rib fusion (HP:0000902)1.71931213
157Bicornuate uterus (HP:0000813)1.71581792
158Abnormal large intestine physiology (HP:0012700)1.70640953
159Generalized hypotonia (HP:0001290)1.70272391
160Abnormal umbilical cord blood vessels (HP:0011403)1.69021221
161Single umbilical artery (HP:0001195)1.69021221
162Abnormality of the fetal cardiovascular system (HP:0010948)1.69021221
163Thick nail (HP:0001805)1.68956353
164Hypoplastic left heart (HP:0004383)1.68702543
165Morphological abnormality of the pyramidal tract (HP:0002062)1.66744133
166Absent hair (HP:0002298)1.66671496
167Congenital sensorineural hearing impairment (HP:0008527)1.65747910
168Erythroderma (HP:0001019)1.65266421
169Scrotal hypoplasia (HP:0000046)1.64985825
170Absent/shortened dynein arms (HP:0200106)1.64513686
171Dynein arm defect of respiratory motile cilia (HP:0012255)1.64513686
172Bell-shaped thorax (HP:0001591)1.63441938
173Duplication of thumb phalanx (HP:0009942)1.62774671
174Rhabdomyosarcoma (HP:0002859)1.62633497
175Glioma (HP:0009733)1.61734274
176Broad metatarsal (HP:0001783)1.61316600
177Hypoglycemic seizures (HP:0002173)1.60880919
178Vitreoretinal degeneration (HP:0000655)1.59467824
179Malignant gastrointestinal tract tumors (HP:0006749)1.56646225
180Gastrointestinal carcinoma (HP:0002672)1.56646225
181Vertebral clefting (HP:0008428)1.55628410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.33155390
2TNIK4.62619998
3OXSR14.36438731
4EPHB13.54797968
5BCR3.23615858
6CDC72.78659314
7MKNK22.70805936
8WNK42.49620256
9TSSK62.45673870
10ICK2.42810576
11PKN12.42136300
12WEE12.39653814
13TTK2.23872776
14CDK192.05176966
15MET1.95344814
16PLK31.89732621
17UHMK11.89534705
18SRPK11.88145001
19MAP3K101.87511477
20CASK1.86493066
21PBK1.83897236
22CSNK1G31.83620301
23CSNK1A1L1.81125911
24FGFR21.80930370
25STK38L1.80464982
26NEK61.80138652
27LATS11.77571013
28TAF11.70611047
29WNK11.70108068
30PNCK1.67718964
31PRPF4B1.66367351
32BUB11.63691622
33MST41.61415653
34VRK21.53112465
35ROCK21.52852319
36LATS21.49508771
37CAMK1D1.48684011
38CSNK1G11.48580225
39PLK41.47914737
40FGR1.43414318
41MARK11.43255102
42LIMK11.41117731
43TYRO31.40063161
44MAPK131.37699281
45IRAK21.36879751
46CSNK1G21.35628130
47NTRK11.33570539
48PAK61.32652418
49CLK11.29086794
50ZAK1.27732773
51DYRK31.26232784
52EPHA41.20244283
53FGFR11.18159675
54MAP3K41.15510673
55DYRK21.15191749
56BRD41.13797010
57NEK21.12929194
58PLK11.12297288
59PAK31.12075844
60CAMK2B1.11297052
61MAPKAPK51.06059513
62VRK11.02921778
63CAMK2D1.02893797
64IRAK11.02878731
65TRIM280.99713153
66STK30.98422840
67NME10.93717744
68ALK0.88496225
69CDK140.83086224
70ERBB40.81799815
71ACVR1B0.78266201
72MAPK150.77400221
73SGK2230.76406321
74SGK4940.76406321
75EPHB20.75808092
76PRKCQ0.75588532
77NLK0.75129368
78ATR0.74255195
79CDK50.73449226
80BMPR1B0.72938652
81CHEK20.72384259
82CAMK2A0.70796231
83ATM0.70781974
84CDK30.70514611
85FES0.69238189
86MARK20.69087758
87NEK10.67902915
88PRKCE0.67208949
89PASK0.66510724
90BRSK20.66420860
91MAP3K90.66403323
92CAMK2G0.66166802
93ROCK10.66076120
94CDK150.65866891
95NTRK20.64089158
96MAP2K70.63850231
97CDK180.62828656
98CDK120.62601062
99PHKG20.61910351
100PHKG10.61910351
101MINK10.60659724
102CDK11A0.59144720
103FYN0.58779853
104ERBB20.57643992
105PRKDC0.57205558
106MKNK10.53936762
107CHEK10.52546983
108STK240.51422275
109CDK10.49603416
110CSNK1D0.48997100
111TIE10.48495267
112PDGFRB0.47731597
113PRKG10.47256518
114CDK20.46848818
115CDK70.46562651
116PRKD10.46460914
117BMX0.45838505
118RPS6KA40.44693171
119PINK10.44393536
120DDR20.42658344
121AURKB0.41890412
122DMPK0.41298410
123GRK10.40771183
124MUSK0.39452924
125GSK3B0.39078369
126SGK20.38627390
127TGFBR10.37829297
128IRAK40.37540917
129CSNK1A10.36757863
130GSK3A0.36504820
131CAMK1G0.35860444
132STK110.33712539
133PDPK10.33498009
134GRK70.33315257
135INSR0.32911687
136NUAK10.31657301
137OBSCN0.31528299
138PRKACA0.30858208
139DYRK1A0.30517492
140PRKACB0.30351499
141CSK0.29349875
142EPHA30.29178589
143RPS6KA50.27566526
144WNK30.26541235
145INSRR0.26465003
146MAPK70.26274169
147CSNK1E0.24351735
148MELK0.24291634
149PTK2B0.24117013
150PLK20.23661920
151STK160.23157610
152PIK3CA0.22307860
153NTRK30.22214349
154PAK10.21220849
155PRKCG0.21001929

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.88620060
2Steroid biosynthesis_Homo sapiens_hsa001005.25745193
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.11348290
4Fatty acid elongation_Homo sapiens_hsa000623.99469994
5Ether lipid metabolism_Homo sapiens_hsa005652.97238898
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43031994
7* Axon guidance_Homo sapiens_hsa043602.42349009
8Mismatch repair_Homo sapiens_hsa034302.37012326
9Non-homologous end-joining_Homo sapiens_hsa034502.22494325
10Oxidative phosphorylation_Homo sapiens_hsa001902.22177184
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10707020
12DNA replication_Homo sapiens_hsa030302.05630173
13Spliceosome_Homo sapiens_hsa030401.94474047
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.92107246
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87217178
16Sulfur metabolism_Homo sapiens_hsa009201.78716186
17Sphingolipid metabolism_Homo sapiens_hsa006001.72805435
18RNA polymerase_Homo sapiens_hsa030201.71221894
19RNA transport_Homo sapiens_hsa030131.69373432
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67748216
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66522567
22Cell cycle_Homo sapiens_hsa041101.63163813
23Selenocompound metabolism_Homo sapiens_hsa004501.61435002
24Protein export_Homo sapiens_hsa030601.60896974
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.60860999
26Butanoate metabolism_Homo sapiens_hsa006501.60790419
27mRNA surveillance pathway_Homo sapiens_hsa030151.59070507
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.55237453
29Homologous recombination_Homo sapiens_hsa034401.52469000
30Alzheimers disease_Homo sapiens_hsa050101.49368203
31Adherens junction_Homo sapiens_hsa045201.46873908
32Serotonergic synapse_Homo sapiens_hsa047261.45915166
33Parkinsons disease_Homo sapiens_hsa050121.45539174
34RNA degradation_Homo sapiens_hsa030181.40670748
35Vitamin digestion and absorption_Homo sapiens_hsa049771.34268050
36Glutamatergic synapse_Homo sapiens_hsa047241.33288922
37Renal cell carcinoma_Homo sapiens_hsa052111.31573690
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30449302
39Base excision repair_Homo sapiens_hsa034101.29120983
40Linoleic acid metabolism_Homo sapiens_hsa005911.29063190
41Ribosome_Homo sapiens_hsa030101.25981853
42Fanconi anemia pathway_Homo sapiens_hsa034601.23979088
43GABAergic synapse_Homo sapiens_hsa047271.18425484
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17490913
45Pyruvate metabolism_Homo sapiens_hsa006201.17053974
46Tight junction_Homo sapiens_hsa045301.14631667
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11816374
48Long-term depression_Homo sapiens_hsa047301.11258847
49Biosynthesis of amino acids_Homo sapiens_hsa012301.10906779
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10191412
51Oocyte meiosis_Homo sapiens_hsa041141.03804852
52Proteasome_Homo sapiens_hsa030501.03506856
53One carbon pool by folate_Homo sapiens_hsa006701.01912879
54Collecting duct acid secretion_Homo sapiens_hsa049660.97949855
55Vibrio cholerae infection_Homo sapiens_hsa051100.96652864
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95729637
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93741870
58Fatty acid metabolism_Homo sapiens_hsa012120.91878426
59Cardiac muscle contraction_Homo sapiens_hsa042600.91507754
60Lysine degradation_Homo sapiens_hsa003100.91181388
61Morphine addiction_Homo sapiens_hsa050320.90428440
62Ovarian steroidogenesis_Homo sapiens_hsa049130.88956928
63Nucleotide excision repair_Homo sapiens_hsa034200.88873110
64Huntingtons disease_Homo sapiens_hsa050160.88790688
65Arginine and proline metabolism_Homo sapiens_hsa003300.88640058
66Ras signaling pathway_Homo sapiens_hsa040140.86243264
67Rheumatoid arthritis_Homo sapiens_hsa053230.85784425
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84347749
69TGF-beta signaling pathway_Homo sapiens_hsa043500.82887325
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82599734
71ECM-receptor interaction_Homo sapiens_hsa045120.81488457
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.81179316
73Nicotine addiction_Homo sapiens_hsa050330.80660442
74Hedgehog signaling pathway_Homo sapiens_hsa043400.80078374
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79469347
76Cholinergic synapse_Homo sapiens_hsa047250.77894518
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.76783963
78Phototransduction_Homo sapiens_hsa047440.76479776
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74470405
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73318090
81Arachidonic acid metabolism_Homo sapiens_hsa005900.72978793
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70444491
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69183103
84Vitamin B6 metabolism_Homo sapiens_hsa007500.68422962
85MicroRNAs in cancer_Homo sapiens_hsa052060.68018148
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.66865723
87Circadian entrainment_Homo sapiens_hsa047130.66109938
88beta-Alanine metabolism_Homo sapiens_hsa004100.65749869
89ErbB signaling pathway_Homo sapiens_hsa040120.65715223
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65391310
91Basal cell carcinoma_Homo sapiens_hsa052170.64865278
92Dopaminergic synapse_Homo sapiens_hsa047280.63051014
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62986210
94Carbon metabolism_Homo sapiens_hsa012000.62224680
95Endocytosis_Homo sapiens_hsa041440.62171167
96Purine metabolism_Homo sapiens_hsa002300.62133874
97Thyroid cancer_Homo sapiens_hsa052160.61459625
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61378856
99Glutathione metabolism_Homo sapiens_hsa004800.60691277
100Fatty acid biosynthesis_Homo sapiens_hsa000610.60401100
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58776395
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.58465134
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56732339
104Protein digestion and absorption_Homo sapiens_hsa049740.56437155
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55871130
106Colorectal cancer_Homo sapiens_hsa052100.55493454
107Autoimmune thyroid disease_Homo sapiens_hsa053200.54799786
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54591814
109Cocaine addiction_Homo sapiens_hsa050300.54263829
110Choline metabolism in cancer_Homo sapiens_hsa052310.54177917
111Fat digestion and absorption_Homo sapiens_hsa049750.53994297
112Folate biosynthesis_Homo sapiens_hsa007900.53884470
113Nitrogen metabolism_Homo sapiens_hsa009100.52832705
114Salivary secretion_Homo sapiens_hsa049700.52687085
115Histidine metabolism_Homo sapiens_hsa003400.52436587
116Gap junction_Homo sapiens_hsa045400.52003941
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51246703
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50886216
119Dorso-ventral axis formation_Homo sapiens_hsa043200.50672557
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49301819
121Notch signaling pathway_Homo sapiens_hsa043300.49108293
122Propanoate metabolism_Homo sapiens_hsa006400.47838099
123Wnt signaling pathway_Homo sapiens_hsa043100.46332689
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46069177
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45078528
126Hippo signaling pathway_Homo sapiens_hsa043900.42818759
127Malaria_Homo sapiens_hsa051440.42540417
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42395504
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42198001
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42141958
131Pyrimidine metabolism_Homo sapiens_hsa002400.41522732
132Peroxisome_Homo sapiens_hsa041460.41453670
133Pancreatic secretion_Homo sapiens_hsa049720.41288893
134Renin secretion_Homo sapiens_hsa049240.40323759
135Synaptic vesicle cycle_Homo sapiens_hsa047210.40167345
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38967628
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38920716
138Phagosome_Homo sapiens_hsa041450.37501674
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.36728391
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36720724
141Basal transcription factors_Homo sapiens_hsa030220.36349704
142Gastric acid secretion_Homo sapiens_hsa049710.36119649
143Mineral absorption_Homo sapiens_hsa049780.35250403
144Focal adhesion_Homo sapiens_hsa045100.35206030
145Oxytocin signaling pathway_Homo sapiens_hsa049210.34772405
146MAPK signaling pathway_Homo sapiens_hsa040100.34054505
147Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33078358
148Melanogenesis_Homo sapiens_hsa049160.32885073
149Metabolic pathways_Homo sapiens_hsa011000.31986460
150cAMP signaling pathway_Homo sapiens_hsa040240.30721193
151Prostate cancer_Homo sapiens_hsa052150.30473535
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28955302
153Dilated cardiomyopathy_Homo sapiens_hsa054140.28717690
154Taste transduction_Homo sapiens_hsa047420.28016232

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