SEMA6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.56888717
2locomotory exploration behavior (GO:0035641)6.49198221
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.32757291
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.05022205
5vocalization behavior (GO:0071625)5.77161726
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.65038578
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.54196329
8regulation of glutamate receptor signaling pathway (GO:1900449)5.27413578
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.13174659
10glutamate secretion (GO:0014047)5.09543401
11negative regulation of interleukin-12 production (GO:0032695)5.06945460
12regulation of mononuclear cell migration (GO:0071675)5.06153976
13synaptic vesicle exocytosis (GO:0016079)5.04883409
14regulation of synaptic vesicle exocytosis (GO:2000300)4.93568333
15regulation of synapse structural plasticity (GO:0051823)4.93099636
16exploration behavior (GO:0035640)4.88543164
17layer formation in cerebral cortex (GO:0021819)4.78617761
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.75522068
19regulation of neuronal synaptic plasticity (GO:0048168)4.72217498
20dendritic spine morphogenesis (GO:0060997)4.67716730
21protein localization to synapse (GO:0035418)4.60671719
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.57948773
23neurotransmitter secretion (GO:0007269)4.47764228
24glycosphingolipid catabolic process (GO:0046479)4.44232537
25regulation of synaptic vesicle transport (GO:1902803)4.41471252
26neurotransmitter-gated ion channel clustering (GO:0072578)4.37510055
27oligosaccharide catabolic process (GO:0009313)4.24881794
28regulation of vitamin D biosynthetic process (GO:0060556)4.21548948
29neuron cell-cell adhesion (GO:0007158)4.16006450
30proline transport (GO:0015824)4.15442695
31gamma-aminobutyric acid transport (GO:0015812)4.11031637
32positive regulation of heat generation (GO:0031652)4.09766201
33synaptic transmission, glutamatergic (GO:0035249)3.99888747
34positive regulation of membrane potential (GO:0045838)3.94306222
35glycolipid catabolic process (GO:0019377)3.93100523
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.92834105
37regulation of dendritic spine morphogenesis (GO:0061001)3.92782993
38long-term memory (GO:0007616)3.92114997
39neuronal action potential propagation (GO:0019227)3.91906211
40positive regulation of chemokine biosynthetic process (GO:0045080)3.90708944
41sodium ion export (GO:0071436)3.89411005
42activation of protein kinase A activity (GO:0034199)3.87039872
43glutamate receptor signaling pathway (GO:0007215)3.86351092
44cellular response to thyroid hormone stimulus (GO:0097067)3.85836786
45negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.84548037
46cellular potassium ion homeostasis (GO:0030007)3.83667851
47response to peptidoglycan (GO:0032494)3.83375701
48lipopolysaccharide-mediated signaling pathway (GO:0031663)3.82272433
49auditory behavior (GO:0031223)3.80610116
50neuromuscular process controlling balance (GO:0050885)3.79252835
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78572502
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.78177815
53regulation of macrophage chemotaxis (GO:0010758)3.69940273
54positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.68376914
55regulation of cytokine secretion involved in immune response (GO:0002739)3.68104482
56adenosine receptor signaling pathway (GO:0001973)3.66643288
57positive regulation of synapse maturation (GO:0090129)3.66595603
58macrophage activation involved in immune response (GO:0002281)3.66065469
59neuron-neuron synaptic transmission (GO:0007270)3.65529598
60G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.64919954
61glycine transport (GO:0015816)3.63917689
62regulation of synaptic plasticity (GO:0048167)3.60524452
63monocyte chemotaxis (GO:0002548)3.59850725
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.58882115
65ceramide catabolic process (GO:0046514)3.57844453
66regulation of cholesterol storage (GO:0010885)3.57039431
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.56959985
68regulation of postsynaptic membrane potential (GO:0060078)3.56335460
69regulation of fever generation (GO:0031620)3.53169233
70prepulse inhibition (GO:0060134)3.52136010
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50458444
72regulation of podosome assembly (GO:0071801)3.50276171
73response to auditory stimulus (GO:0010996)3.49340056
74neurotransmitter transport (GO:0006836)3.48229141
75membrane lipid catabolic process (GO:0046466)3.45615974
76dendritic spine organization (GO:0097061)3.40561969
77cell communication by electrical coupling (GO:0010644)3.39844948
78dendrite morphogenesis (GO:0048813)3.37175538
79low-density lipoprotein particle clearance (GO:0034383)3.34834802
80regulation of membrane protein ectodomain proteolysis (GO:0051043)3.34431912
81regulation of ARF protein signal transduction (GO:0032012)3.33459265
82regulation of neurotransmitter levels (GO:0001505)3.32441538
83T-helper 1 type immune response (GO:0042088)3.31277915
84neuron recognition (GO:0008038)3.30449536
85positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.30397235
86positive regulation of neurotransmitter secretion (GO:0001956)3.29678206
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29059885
88transmission of nerve impulse (GO:0019226)3.28187012
89sphingolipid catabolic process (GO:0030149)3.27620155
90regulation of neurotransmitter secretion (GO:0046928)3.26936696
91regulation of dendritic spine development (GO:0060998)3.26028510
92positive regulation of dendritic spine development (GO:0060999)3.25495671
93regulation of synaptic transmission, glutamatergic (GO:0051966)3.24181721
94synaptic vesicle endocytosis (GO:0048488)3.23403108
95amino sugar catabolic process (GO:0046348)3.23260374
96negative regulation of nitric oxide biosynthetic process (GO:0045019)3.22829931
97postsynaptic membrane organization (GO:0001941)3.22439461
98positive regulation of neurotransmitter transport (GO:0051590)3.21116247
99regulation of chemokine biosynthetic process (GO:0045073)3.19953129
100myeloid dendritic cell differentiation (GO:0043011)3.18772794
101neuronal ion channel clustering (GO:0045161)3.16511865
102neuromuscular process controlling posture (GO:0050884)3.16350488
103response to acidic pH (GO:0010447)3.15683851
104long-term synaptic potentiation (GO:0060291)3.11295412
105protein localization to endosome (GO:0036010)3.08765862
106regulation of vitamin metabolic process (GO:0030656)3.07744865
107NIK/NF-kappaB signaling (GO:0038061)3.06403942
108negative regulation of amino acid transport (GO:0051956)3.05627035
109axonal fasciculation (GO:0007413)3.05415976
110cerebellar Purkinje cell layer development (GO:0021680)3.04917828
111L-amino acid import (GO:0043092)3.04554163
112vesicle transport along microtubule (GO:0047496)3.03196021
113regulation of neurotransmitter transport (GO:0051588)3.03106856
114negative regulation of cytokine production involved in immune response (GO:0002719)3.02203318
115membrane depolarization (GO:0051899)3.01092123
116adhesion of symbiont to host cell (GO:0044650)3.00862008
117virion attachment to host cell (GO:0019062)3.00862008
118social behavior (GO:0035176)3.00336224
119intraspecies interaction between organisms (GO:0051703)3.00336224
120regulation of vesicle fusion (GO:0031338)2.99634180
121regulation of heat generation (GO:0031650)2.99429121
122activation of MAPKKK activity (GO:0000185)2.98993197
123N-acetylneuraminate metabolic process (GO:0006054)2.98858778
124cerebellar Purkinje cell differentiation (GO:0021702)2.98188952
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97414802
126learning (GO:0007612)2.96166596
127potassium ion import (GO:0010107)2.94971418
128positive regulation of dendritic spine morphogenesis (GO:0061003)2.94848089
129membrane hyperpolarization (GO:0060081)2.94107265
130neuromuscular process (GO:0050905)2.93916948
131positive regulation of synaptic transmission (GO:0050806)2.93284039
132branching involved in labyrinthine layer morphogenesis (GO:0060670)2.92123398
133membrane depolarization during action potential (GO:0086010)2.91107527
134regulation of synaptic transmission (GO:0050804)2.90691963
135regulation of female receptivity (GO:0045924)2.88763221
136clathrin coat assembly (GO:0048268)2.85246668
137synapse assembly (GO:0007416)2.84298006
138negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83834118
139alanine transport (GO:0032328)2.83494649
140response to thyroid hormone (GO:0097066)2.83371853
141mating behavior (GO:0007617)2.82046708
142gamma-aminobutyric acid signaling pathway (GO:0007214)2.81880226
143mechanosensory behavior (GO:0007638)2.81765815
144cellular sodium ion homeostasis (GO:0006883)2.79378856
145neutrophil activation involved in immune response (GO:0002283)2.77985027
146cellular response to lipopolysaccharide (GO:0071222)2.74936819
147ganglioside metabolic process (GO:0001573)2.74303723
148regulation of T-helper 2 cell differentiation (GO:0045628)2.72066360
149negative regulation of myeloid cell apoptotic process (GO:0033033)2.71151761
150cellular response to arsenic-containing substance (GO:0071243)2.70964986
151germinal center formation (GO:0002467)2.70358513
152regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.69344028
153macrophage activation (GO:0042116)2.69239698
154regulation of chronic inflammatory response (GO:0002676)2.68663032
155response to manganese ion (GO:0010042)2.68448235
156positive regulation of monocyte chemotaxis (GO:0090026)2.68239598
157adhesion of symbiont to host (GO:0044406)2.68047479
158positive regulation of leukocyte degranulation (GO:0043302)2.66287681
159cellular response to molecule of bacterial origin (GO:0071219)2.64179717
160positive regulation of NF-kappaB import into nucleus (GO:0042346)2.62813555
161regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.61388864
162phagosome maturation (GO:0090382)2.56200723
163cell-cell junction maintenance (GO:0045217)2.55493198
164regulation of early endosome to late endosome transport (GO:2000641)2.55288529
165positive regulation of mast cell degranulation (GO:0043306)2.54729588
166positive regulation of mast cell activation involved in immune response (GO:0033008)2.54729588
167regulation of nitric oxide biosynthetic process (GO:0045428)2.53109175
168plasma lipoprotein particle clearance (GO:0034381)2.50583901
169negative regulation of erythrocyte differentiation (GO:0045647)2.50225637
170regulation of T-helper 1 cell differentiation (GO:0045625)2.49595278
171myeloid dendritic cell activation (GO:0001773)2.49134021
172positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.48073220
173regulation of mast cell degranulation (GO:0043304)2.43739306
174positive regulation of cholesterol efflux (GO:0010875)2.43252889
175negative regulation of adherens junction organization (GO:1903392)2.42177448
176negative regulation of focal adhesion assembly (GO:0051895)2.42177448
177negative regulation of cell junction assembly (GO:1901889)2.42177448
178barbed-end actin filament capping (GO:0051016)2.41974583
179negative regulation of production of molecular mediator of immune response (GO:0002701)2.41458214
180regulation of leukocyte degranulation (GO:0043300)2.38897960
181response to magnesium ion (GO:0032026)2.38138916
182regulation of prostaglandin secretion (GO:0032306)2.37602226
183dendritic cell differentiation (GO:0097028)2.36338794
184positive regulation of lymphocyte apoptotic process (GO:0070230)2.35888752
185response to muramyl dipeptide (GO:0032495)2.34895154
186endothelium development (GO:0003158)2.34313978
187lysosome organization (GO:0007040)2.32623842
188lytic vacuole organization (GO:0080171)2.32623842
189negative regulation of lipid storage (GO:0010888)2.32327984
190regulation of interleukin-12 production (GO:0032655)2.31854299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58969677
2NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.43939080
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.04814993
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03871677
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00756670
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99959581
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.97013879
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.95479974
9* DROSHA_22980978_ChIP-Seq_HELA_Human2.82639243
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79304436
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79304436
12REST_21632747_ChIP-Seq_MESCs_Mouse2.72984751
13GBX2_23144817_ChIP-Seq_PC3_Human2.67905536
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67205711
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58846422
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58528423
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.54437985
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50452775
19* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49272227
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.48541027
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43039638
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42576143
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.39124033
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37319892
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37131943
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35476888
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.32393614
28IRF8_22096565_ChIP-ChIP_GC-B_Human2.32147298
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.27545391
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.25578632
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22641187
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10467234
33STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09439633
34EED_16625203_ChIP-ChIP_MESCs_Mouse2.08454728
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04622427
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93549945
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88779301
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.86483036
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.85222360
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84933849
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.82616424
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81412797
43VDR_21846776_ChIP-Seq_THP-1_Human1.80660707
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79542219
45AR_21572438_ChIP-Seq_LNCaP_Human1.77273875
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72660743
47* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.62603847
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.60444518
49* KDM2B_26808549_Chip-Seq_K562_Human1.58275400
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53162576
51SPI1_23127762_ChIP-Seq_K562_Human1.52814507
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51875931
53* RING1B_27294783_Chip-Seq_ESCs_Mouse1.45750821
54* VDR_24763502_ChIP-Seq_THP-1_Human1.44804265
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43095668
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42594621
57* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42247182
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41773931
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40247126
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39942839
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39337138
62* VDR_24787735_ChIP-Seq_THP-1_Human1.39319254
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39041661
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38763953
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37134832
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35476490
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35198542
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34023882
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32769049
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32064512
71* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31548387
72TCF7_22412390_ChIP-Seq_EML_Mouse1.31370117
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30620016
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30297788
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29667016
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29615794
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28179145
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26433651
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26169390
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25882424
81P68_20966046_ChIP-Seq_HELA_Human1.24830278
82SMAD4_21799915_ChIP-Seq_A2780_Human1.24041201
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.22549833
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22207885
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.21962593
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21264215
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.20915021
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20168080
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.19954709
90AR_19668381_ChIP-Seq_PC3_Human1.19788326
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.19206099
92* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19170608
93ZNF274_21170338_ChIP-Seq_K562_Hela1.18514838
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18091685
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16894206
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16894066
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16827556
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16098239
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14699276
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14263726
101BCOR_27268052_Chip-Seq_Bcells_Human1.13333161
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12662838
103* BCL6_27268052_Chip-Seq_Bcells_Human1.12435416
104SA1_27219007_Chip-Seq_Bcells_Human1.12267465
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11249949
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10589351
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09231188
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07709649
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07673278
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07320220
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05690470
112RACK7_27058665_Chip-Seq_MCF-7_Human1.04298469
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04161992
114CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03819948
115CTCF_27219007_Chip-Seq_Bcells_Human1.03616948
116SMAD_19615063_ChIP-ChIP_OVARY_Human1.03488221
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02299018
118TET1_21451524_ChIP-Seq_MESCs_Mouse1.01850666
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01567379
120TET1_21490601_ChIP-Seq_MESCs_Mouse1.01079793
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00817189
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00501427
123LXR_22292898_ChIP-Seq_THP-1_Human1.00438739
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99680959
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.99557179
126SMAD3_21741376_ChIP-Seq_EPCs_Human0.98795674
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98734453
128GATA1_19941826_ChIP-Seq_K562_Human0.98006680
129AR_25329375_ChIP-Seq_VCAP_Human0.97028383
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96780955
131* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96254604
132STAT3_23295773_ChIP-Seq_U87_Human0.96198181
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95935028
134KDM2B_26808549_Chip-Seq_JURKAT_Human0.95540062
135AHR_22903824_ChIP-Seq_MCF-7_Human0.95379816
136RXR_22108803_ChIP-Seq_LS180_Human0.95289916
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95127469
138* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94998695
139* SA1_27219007_Chip-Seq_ERYTHROID_Human0.94766555
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.93817945
141YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93666912
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92608427
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.92144954
144* KDM2B_26808549_Chip-Seq_DND41_Human0.92068357
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91462223
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.90536660
147CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90102896
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.89914429
149* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89596318
150KLF4_19829295_ChIP-Seq_ESCs_Human0.89416644
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87120534
152TCF4_23295773_ChIP-Seq_U87_Human0.83656159
153TAF15_26573619_Chip-Seq_HEK293_Human0.82734497
154TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82685211
155SMC4_20622854_ChIP-Seq_HELA_Human0.81570423
156CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81448640
157BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81139944
158TP53_16413492_ChIP-PET_HCT116_Human0.80342576
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79021470
160PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79010018
161OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78476175
162TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78446397
163P300_19829295_ChIP-Seq_ESCs_Human0.78221981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.49490661
2MP0005058_abnormal_lysosome_morphology5.05606062
3MP0003880_abnormal_central_pattern4.45924893
4MP0003635_abnormal_synaptic_transmissio4.38545349
5MP0004270_analgesia3.74701356
6MP0009840_abnormal_foam_cell3.62288185
7MP0009745_abnormal_behavioral_response3.49607294
8MP0002822_catalepsy3.49136692
9MP0002063_abnormal_learning/memory/cond3.47303892
10MP0006082_CNS_inflammation3.43115437
11MP0002064_seizures3.20087742
12MP0005423_abnormal_somatic_nervous3.05470245
13MP0009046_muscle_twitch2.95108197
14MP0002148_abnormal_hypersensitivity_rea2.85729256
15MP0002572_abnormal_emotion/affect_behav2.74103155
16MP0001968_abnormal_touch/_nociception2.67050383
17MP0001486_abnormal_startle_reflex2.60682179
18MP0002139_abnormal_hepatobiliary_system2.59585192
19MP0002734_abnormal_mechanical_nocicepti2.47317775
20MP0000343_altered_response_to2.45348406
21MP0002254_reproductive_system_inflammat2.45005451
22MP0002272_abnormal_nervous_system2.40151548
23MP0003436_decreased_susceptibility_to2.38480222
24MP0009780_abnormal_chondrocyte_physiolo2.29959958
25MP0001501_abnormal_sleep_pattern2.25881524
26MP0009785_altered_susceptibility_to2.21799192
27MP0004858_abnormal_nervous_system2.15614561
28MP0009764_decreased_sensitivity_to2.10859575
29MP0003724_increased_susceptibility_to2.09653542
30MP0003300_gastrointestinal_ulcer2.05073839
31MP0003329_amyloid_beta_deposits2.03269599
32MP0002909_abnormal_adrenal_gland2.01185592
33MP0002419_abnormal_innate_immunity1.98391669
34MP0008569_lethality_at_weaning1.96965013
35MP0001440_abnormal_grooming_behavior1.96016766
36MP0004811_abnormal_neuron_physiology1.92263754
37MP0002733_abnormal_thermal_nociception1.89911883
38MP0002736_abnormal_nociception_after1.88706978
39MP0002735_abnormal_chemical_nociception1.85430490
40MP0001970_abnormal_pain_threshold1.84474216
41MP0005000_abnormal_immune_tolerance1.83383690
42MP0005671_abnormal_response_to1.81334811
43MP0006054_spinal_hemorrhage1.78304943
44MP0004924_abnormal_behavior1.73076093
45MP0005386_behavior/neurological_phenoty1.73076093
46MP0009278_abnormal_bone_marrow1.72191754
47MP0003879_abnormal_hair_cell1.70909143
48MP0002067_abnormal_sensory_capabilities1.70323721
49MP0002557_abnormal_social/conspecific_i1.69708354
50MP0002998_abnormal_bone_remodeling1.66181956
51MP0005025_abnormal_response_to1.65024513
52MP0000778_abnormal_nervous_system1.63226680
53MP0004885_abnormal_endolymph1.61895039
54MP0002184_abnormal_innervation1.60428036
55MP0001533_abnormal_skeleton_physiology1.60427864
56MP0001790_abnormal_immune_system1.53643584
57MP0005387_immune_system_phenotype1.53643584
58MP0000955_abnormal_spinal_cord1.52004810
59MP0003633_abnormal_nervous_system1.51928689
60MP0003075_altered_response_to1.47765904
61MP0005167_abnormal_blood-brain_barrier1.47386413
62MP0005646_abnormal_pituitary_gland1.43087008
63MP0002066_abnormal_motor_capabilities/c1.40302789
64MP0001853_heart_inflammation1.35402094
65MP0002882_abnormal_neuron_morphology1.32083216
66MP0008961_abnormal_basal_metabolism1.31190600
67MP0000751_myopathy1.30782490
68MP0003453_abnormal_keratinocyte_physiol1.30634976
69MP0002452_abnormal_antigen_presenting1.26226695
70MP0000685_abnormal_immune_system1.26149097
71MP0005310_abnormal_salivary_gland1.24590740
72MP0003191_abnormal_cellular_cholesterol1.23620681
73MP0003631_nervous_system_phenotype1.22575143
74MP0002723_abnormal_immune_serum1.21713998
75MP0003448_altered_tumor_morphology1.21253624
76MP0003690_abnormal_glial_cell1.20179527
77MP0003787_abnormal_imprinting1.19617323
78MP0005451_abnormal_body_composition1.19276906
79MP0008469_abnormal_protein_level1.18621419
80MP0001835_abnormal_antigen_presentation1.16037141
81MP0005645_abnormal_hypothalamus_physiol1.15879982
82MP0000569_abnormal_digit_pigmentation1.14635835
83MP0001845_abnormal_inflammatory_respons1.13820091
84MP0004947_skin_inflammation1.13371115
85MP0005595_abnormal_vascular_smooth1.12818566
86MP0002332_abnormal_exercise_endurance1.12806682
87MP0001502_abnormal_circadian_rhythm1.11950549
88MP0008874_decreased_physiological_sensi1.10862740
89MP0001984_abnormal_olfaction1.10035227
90MP0002138_abnormal_hepatobiliary_system1.07952018
91MP0003283_abnormal_digestive_organ1.07504602
92MP0001529_abnormal_vocalization1.06207154
93* MP0002152_abnormal_brain_morphology1.06181646
94MP0000604_amyloidosis1.05239476
95MP0001545_abnormal_hematopoietic_system1.04645332
96MP0005397_hematopoietic_system_phenotyp1.04645332
97MP0005165_increased_susceptibility_to1.04219430
98MP0001177_atelectasis1.04074121
99MP0002405_respiratory_system_inflammati1.02655716
100MP0000013_abnormal_adipose_tissue1.01818614
101MP0006276_abnormal_autonomic_nervous1.01283926
102MP0000858_altered_metastatic_potential1.00882044
103MP0001905_abnormal_dopamine_level0.99454664
104MP0003828_pulmonary_edema0.99253447
105MP0004085_abnormal_heartbeat0.98592478
106MP0004510_myositis0.98388363
107MP0004142_abnormal_muscle_tone0.98101764
108MP0003195_calcinosis0.97813205
109MP0008872_abnormal_physiological_respon0.94692343
110MP0003172_abnormal_lysosome_physiology0.94374059
111MP0002069_abnormal_eating/drinking_beha0.93736172
112MP0001849_ear_inflammation0.93731123
113MP0003806_abnormal_nucleotide_metabolis0.93556827
114MP0001819_abnormal_immune_cell0.92850808
115MP0002420_abnormal_adaptive_immunity0.92147778
116MP0003634_abnormal_glial_cell0.90860536
117MP0000920_abnormal_myelination0.90290998
118MP0005535_abnormal_body_temperature0.89286493
119MP0003303_peritoneal_inflammation0.88276374
120MP0005464_abnormal_platelet_physiology0.86726515
121MP0010155_abnormal_intestine_physiology0.86095060
122MP0001800_abnormal_humoral_immune0.83546728
123MP0002229_neurodegeneration0.83211021
124MP0004130_abnormal_muscle_cell0.82331625
125MP0003632_abnormal_nervous_system0.81926839
126MP0004215_abnormal_myocardial_fiber0.81635817
127MP0010234_abnormal_vibrissa_follicle0.81158774
128MP0002090_abnormal_vision0.77641879
129MP0010368_abnormal_lymphatic_system0.77554029
130MP0001663_abnormal_digestive_system0.76976912
131MP0005257_abnormal_intraocular_pressure0.75208833
132MP0003137_abnormal_impulse_conducting0.73973967
133MP0008260_abnormal_autophagy0.73278686
134MP0003122_maternal_imprinting0.71434129
135MP0004145_abnormal_muscle_electrophysio0.70824556
136MP0002933_joint_inflammation0.70154202
137MP0008004_abnormal_stomach_pH0.69845956
138MP0000750_abnormal_muscle_regeneration0.69493369
139MP0003183_abnormal_peptide_metabolism0.69110414
140MP0003123_paternal_imprinting0.67891949
141MP0003279_aneurysm0.67131573
142MP0005623_abnormal_meninges_morphology0.67124278
143MP0009333_abnormal_splenocyte_physiolog0.67047339
144MP0004484_altered_response_of0.64718469
145MP0005166_decreased_susceptibility_to0.63791643
146MP0005390_skeleton_phenotype0.63749959
147MP0001915_intracranial_hemorrhage0.62690114
148MP0005365_abnormal_bile_salt0.62453740
149MP0004233_abnormal_muscle_weight0.62049188
150MP0001963_abnormal_hearing_physiology0.59881248
151MP0005409_darkened_coat_color0.59375308
152MP0002089_abnormal_postnatal_growth/wei0.59176289
153MP0004742_abnormal_vestibular_system0.58783014
154MP0005499_abnormal_olfactory_system0.57595078
155MP0005394_taste/olfaction_phenotype0.57595078
156MP0002837_dystrophic_cardiac_calcinosis0.55286908
157MP0000747_muscle_weakness0.52801200
158MP0010769_abnormal_survival0.52722982
159MP0005187_abnormal_penis_morphology0.51936822
160MP0001943_abnormal_respiration0.51209783
161MP0000631_abnormal_neuroendocrine_gland0.50953671
162MP0002752_abnormal_somatic_nervous0.49555448
163MP0001299_abnormal_eye_distance/0.49311216
164MP0001664_abnormal_digestion0.49168870
165MP0002082_postnatal_lethality0.48546637
166MP0010770_preweaning_lethality0.48546637

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)8.09025360
2Abnormality of glycosphingolipid metabolism (HP:0004343)8.09025360
3Abnormality of glycolipid metabolism (HP:0010969)8.09025360
4Myokymia (HP:0002411)7.42006874
5Focal motor seizures (HP:0011153)6.61450064
6Increased cerebral lipofuscin (HP:0011813)6.26812185
7Vacuolated lymphocytes (HP:0001922)5.49972393
8Visual hallucinations (HP:0002367)5.44165324
9Focal seizures (HP:0007359)5.36085116
10Increased neuronal autofluorescent lipopigment (HP:0002074)5.26142918
11Disinhibition (HP:0000734)5.18970275
12Dysostosis multiplex (HP:0000943)5.12135059
13Systemic lupus erythematosus (HP:0002725)4.81428039
14Loss of speech (HP:0002371)4.47246502
15Nuclear cataract (HP:0100018)4.25213734
16Action tremor (HP:0002345)4.07198619
17Supranuclear gaze palsy (HP:0000605)4.05880415
18Epileptic encephalopathy (HP:0200134)4.00837208
19Abnormality of polysaccharide metabolism (HP:0011012)3.93119150
20Abnormality of glycosaminoglycan metabolism (HP:0004371)3.93119150
21Abnormality of mucopolysaccharide metabolism (HP:0011020)3.93119150
22Progressive cerebellar ataxia (HP:0002073)3.80010848
23Ankle clonus (HP:0011448)3.77770788
24Axonal loss (HP:0003447)3.77424701
25Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.76651766
26Poor eye contact (HP:0000817)3.68265760
27Mutism (HP:0002300)3.67208673
28Urinary glycosaminoglycan excretion (HP:0003541)3.64043609
29Mucopolysacchariduria (HP:0008155)3.64043609
30Papilledema (HP:0001085)3.61826592
31Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.59768064
32Atonic seizures (HP:0010819)3.59056092
33Generalized tonic-clonic seizures (HP:0002069)3.53890313
34Febrile seizures (HP:0002373)3.52422870
35Absence seizures (HP:0002121)3.49646789
36Impaired vibration sensation in the lower limbs (HP:0002166)3.44586955
37Abnormality of the lower motor neuron (HP:0002366)3.44050950
38Abnormality of macrophages (HP:0004311)3.43832960
39Depression (HP:0000716)3.43361522
40Impaired social interactions (HP:0000735)3.36615419
41Abnormal social behavior (HP:0012433)3.36615419
42Postural instability (HP:0002172)3.33778698
43Broad-based gait (HP:0002136)3.31023580
44Urinary bladder sphincter dysfunction (HP:0002839)3.31002309
45Abnormality of the vasculature of the conjunctiva (HP:0008054)3.30467391
46Autoimmune thrombocytopenia (HP:0001973)3.29731636
47Glomerulonephritis (HP:0000099)3.28730667
48Hematochezia (HP:0002573)3.20971647
49Dialeptic seizures (HP:0011146)3.17372755
50Torticollis (HP:0000473)3.16322714
51Agnosia (HP:0010524)3.10827301
52Retinal atrophy (HP:0001105)3.08650403
53Dysdiadochokinesis (HP:0002075)3.05863331
54Anxiety (HP:0000739)3.04716306
55Hemiplegia (HP:0002301)3.04252857
56Dysmetria (HP:0001310)2.97338714
57Urinary urgency (HP:0000012)2.95658482
58Abnormal eating behavior (HP:0100738)2.94085581
59Dementia (HP:0000726)2.88581145
60Focal dystonia (HP:0004373)2.88103596
61Neurofibrillary tangles (HP:0002185)2.83770558
62Gaze-evoked nystagmus (HP:0000640)2.83363683
63Cerebral inclusion bodies (HP:0100314)2.82780017
64Ventricular fibrillation (HP:0001663)2.82083252
65Genetic anticipation (HP:0003743)2.81954404
66Annular pancreas (HP:0001734)2.77563481
67Upper motor neuron abnormality (HP:0002127)2.77544492
68Intention tremor (HP:0002080)2.76159401
69Complement deficiency (HP:0004431)2.74368524
70Personality changes (HP:0000751)2.73774264
71Truncal ataxia (HP:0002078)2.67641242
72Amblyopia (HP:0000646)2.63729110
73Spastic gait (HP:0002064)2.61036606
74Stereotypic behavior (HP:0000733)2.60722531
75Megalencephaly (HP:0001355)2.60694324
76Impaired smooth pursuit (HP:0007772)2.60383790
77Orchitis (HP:0100796)2.60135513
78Craniofacial dystonia (HP:0012179)2.58878166
79Bradykinesia (HP:0002067)2.58521879
80Diplopia (HP:0000651)2.58202038
81Abnormality of binocular vision (HP:0011514)2.58202038
82Insomnia (HP:0100785)2.57437913
83Optic neuritis (HP:0100653)2.56689723
84Retrobulbar optic neuritis (HP:0100654)2.56689723
85Obstructive sleep apnea (HP:0002870)2.56066783
86Pointed chin (HP:0000307)2.51191507
87Bundle branch block (HP:0011710)2.50333450
88Hemiparesis (HP:0001269)2.47334700
89Amyloidosis (HP:0011034)2.46494698
90Drooling (HP:0002307)2.43216634
91Excessive salivation (HP:0003781)2.43216634
92Purpura (HP:0000979)2.42599450
93Stomatitis (HP:0010280)2.41064240
94Dysmetric saccades (HP:0000641)2.41020683
95Myocardial infarction (HP:0001658)2.37764869
96Lower limb amyotrophy (HP:0007210)2.36362222
97Increased serum ferritin (HP:0003281)2.33069232
98Lower limb muscle weakness (HP:0007340)2.31132786
99Mediastinal lymphadenopathy (HP:0100721)2.30908361
100Progressive inability to walk (HP:0002505)2.29857863
101Hyperventilation (HP:0002883)2.29749578
102Abnormality of ocular smooth pursuit (HP:0000617)2.26768399
103Progressive neurologic deterioration (HP:0002344)2.25592504
104Apathy (HP:0000741)2.25549776
105Amyotrophic lateral sclerosis (HP:0007354)2.25260182
106Limb dystonia (HP:0002451)2.23774517
107Memory impairment (HP:0002354)2.23704145
108Impaired vibratory sensation (HP:0002495)2.23454939
109Metaphyseal irregularity (HP:0003025)2.23028813
110Insidious onset (HP:0003587)2.22808524
111Termporal pattern (HP:0011008)2.22808524
112Scanning speech (HP:0002168)2.22440449
113Mesangial abnormality (HP:0001966)2.19580073
114Abnormality of the corticospinal tract (HP:0002492)2.17487989
115Resting tremor (HP:0002322)2.16858123
116Myositis (HP:0100614)2.16498342
117Status epilepticus (HP:0002133)2.14348892
118Recurrent bacterial skin infections (HP:0005406)2.13948877
119Rapidly progressive (HP:0003678)2.12768129
120Prolonged neonatal jaundice (HP:0006579)2.12742055
121Neuronal loss in central nervous system (HP:0002529)2.11568060
122Fetal akinesia sequence (HP:0001989)2.06836056
123Epileptiform EEG discharges (HP:0011182)2.06463676
124Recurrent abscess formation (HP:0002722)2.06129411
125EEG with generalized epileptiform discharges (HP:0011198)2.04829856
126Recurrent gram-negative bacterial infections (HP:0005420)2.04128016
127Abnormal EKG (HP:0003115)2.03783834
128Ankyloglossia (HP:0010296)2.03293377
129Pathologic fracture (HP:0002756)2.02732178
130Conjunctival telangiectasia (HP:0000524)2.01918257
131Inappropriate behavior (HP:0000719)2.01822346
132Abnormality of complement system (HP:0005339)2.01614835
133Hypsarrhythmia (HP:0002521)2.00911432
134Generalized myoclonic seizures (HP:0002123)2.00570759
135Clonus (HP:0002169)1.99740986
136Zonular cataract (HP:0010920)1.98268107
137Diminished motivation (HP:0000745)1.97556104
138Lower limb asymmetry (HP:0100559)1.96949151
139Peripheral demyelination (HP:0011096)1.95483448
140Incomplete penetrance (HP:0003829)1.95303957
141Abnormality of the periventricular white matter (HP:0002518)1.94121513
142Rigidity (HP:0002063)1.92676630
143Agitation (HP:0000713)1.92207587
144Eczematoid dermatitis (HP:0000976)1.90217410
145Polyphagia (HP:0002591)1.88927799
146Urinary incontinence (HP:0000020)1.88466739
147Abnormality of saccadic eye movements (HP:0000570)1.87872951
148Global brain atrophy (HP:0002283)1.86532748
149Spontaneous hematomas (HP:0007420)1.82369850
150Hyperacusis (HP:0010780)1.82285253
151Absent speech (HP:0001344)1.79774450
152J-shaped sella turcica (HP:0002680)1.79430066
153Akinesia (HP:0002304)1.79191000
154Gait ataxia (HP:0002066)1.79030789
155Asymmetric septal hypertrophy (HP:0001670)1.78603996
156Esophageal varix (HP:0002040)1.78577726
157Abnormality of the nasal mucosa (HP:0000433)1.78321192
158Delusions (HP:0000746)1.77671211
159Spinal canal stenosis (HP:0003416)1.76949076
160Spastic tetraparesis (HP:0001285)1.76198284
161Intellectual disability, profound (HP:0002187)1.75763631
162Basal ganglia calcification (HP:0002135)1.75729016
163Polyneuropathy (HP:0001271)1.75463240
164Tetraplegia (HP:0002445)1.74994965
165Anosmia (HP:0000458)1.74618883
166Cerebral aneurysm (HP:0004944)1.74322501
167Progressive visual loss (HP:0000529)1.70861874
168Thoracic kyphosis (HP:0002942)1.68894807
169Cardiomegaly (HP:0001640)1.68636767
170Abnormality of the lumbar spine (HP:0100712)1.66278777
171Dysphonia (HP:0001618)1.65890368
172Xanthomatosis (HP:0000991)1.65746810
173Cerebral hemorrhage (HP:0001342)1.64303540
174Abnormality of iron homeostasis (HP:0011031)1.60516467
175Vertebral compression fractures (HP:0002953)1.58307421
176Hepatosplenomegaly (HP:0001433)1.57745729
177Pulmonary infiltrates (HP:0002113)1.57375868
178Tetraparesis (HP:0002273)1.57082672
179Chronic obstructive pulmonary disease (HP:0006510)1.57002770
180Obstructive lung disease (HP:0006536)1.57002770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.85965745
2EPHA44.57004634
3MAP3K94.19728233
4NME24.15486776
5NTRK34.07077912
6MARK13.46612995
7MAP3K112.91100088
8TGFBR22.86515717
9DAPK22.85710442
10PRKD32.73543371
11MINK12.63260600
12GRK72.55970836
13MAP3K42.50493717
14PAK62.47542162
15KSR22.29658272
16TAOK22.29102128
17CAMKK12.28000198
18NTRK22.24214789
19MATK2.18476115
20NTRK12.03912261
21MAP3K141.90841506
22MOS1.85768534
23SIK21.85563699
24MAP2K71.80656279
25TBK11.66160943
26ABL21.64928340
27MAP2K41.63783267
28CDK51.62848039
29RIPK41.60609160
30KSR11.52178810
31DAPK11.50102286
32STK381.49753884
33FES1.44562413
34CAMK1D1.42942241
35ADRBK21.37168173
36TAOK11.36283225
37PIM21.35632408
38TYRO31.34575432
39BLK1.29129028
40CSK1.28261087
41IRAK41.27275975
42RIPK11.26188306
43PHKG11.24394463
44PHKG21.24394463
45PRPF4B1.24344965
46MAP3K131.23475271
47MAP3K121.22725340
48LATS21.21235893
49GRK51.20124337
50ALK1.19633663
51ACVR1B1.18034463
52MAP3K21.15487016
53IKBKB1.14271724
54UHMK11.12383096
55PRKCH1.11908827
56STK111.08028260
57PRKCG1.06677991
58PLK21.06587868
59ARAF1.05142618
60MAP2K31.04459932
61ERN11.03345576
62CAMK11.02369626
63MAP2K60.99839036
64MAPK130.97309766
65RET0.96243639
66KDR0.94946046
67MARK20.90464090
68MAP3K30.88492741
69TESK10.88378287
70CDK150.88344844
71TNIK0.87315345
72CDK180.86641915
73CAMKK20.85578907
74PTK2B0.85348094
75LMTK20.84607998
76CDK190.84103473
77CDK140.82240742
78TRIB30.82171626
79LIMK10.82040545
80CAMK2A0.79991029
81PRKG20.79169487
82SGK2230.78694478
83SGK4940.78694478
84CHUK0.78607012
85RAF10.76739149
86PDK10.76716701
87SGK30.76448293
88PINK10.76202203
89CDK11A0.76095599
90SCYL20.74064797
91PDPK10.73515760
92PAK30.71334313
93TGFBR10.69241139
94SGK10.66742385
95IRAK20.66357697
96MAP3K10.65659947
97MAP3K70.65398914
98CAMK40.65381359
99CAMK1G0.63360954
100SGK20.62499339
101BRAF0.62249181
102PNCK0.61782403
103EPHB20.61692403
104DMPK0.61172132
105ICK0.59700551
106CSNK1G20.58401703
107MAP4K10.57567384
108PRKCZ0.57545890
109BMPR20.57391471
110NEK10.56291659
111TYK20.55057347
112CAMK2B0.54049586
113DYRK1A0.53677016
114RPS6KA30.52799900
115FYN0.52053155
116CSF1R0.51603559
117DAPK30.50784000
118PKN20.50577062
119TNK20.49912865
120ZAP700.49753433
121BRSK10.49083504
122MAP3K50.47508105
123IKBKE0.45431566
124JAK30.44977771
125CDC42BPA0.44827002
126SYK0.44029950
127MAPK100.43667697
128PDGFRA0.43033460
129DDR20.42617543
130FGFR40.42175443
131MAPK120.41691581
132CASK0.41466591
133BMX0.40244289
134TESK20.39894515
135RPS6KA20.39572682
136LYN0.38159379
137FGFR20.37831022
138MAP2K10.36613322
139MAPK40.36537660
140MAP3K60.35485682
141FGR0.35296660
142PRKCE0.30638836
143RPS6KL10.30091360
144RPS6KC10.30091360
145PAK40.30048403
146PKN10.29092066
147CAMK2G0.28965969
148TIE10.28863830
149PRKCB0.28092454
150SRC0.27203438

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.27153825
2Lysosome_Homo sapiens_hsa041423.51983898
3Nicotine addiction_Homo sapiens_hsa050333.09625680
4Synaptic vesicle cycle_Homo sapiens_hsa047213.01383065
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.80301423
6Olfactory transduction_Homo sapiens_hsa047402.76697521
7Rheumatoid arthritis_Homo sapiens_hsa053232.67530884
8Circadian entrainment_Homo sapiens_hsa047132.57549758
9GABAergic synapse_Homo sapiens_hsa047272.54901374
10Long-term potentiation_Homo sapiens_hsa047202.46774223
11Glutamatergic synapse_Homo sapiens_hsa047242.42755447
12Osteoclast differentiation_Homo sapiens_hsa043802.38157063
13Morphine addiction_Homo sapiens_hsa050322.36502460
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34287980
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31374506
16Staphylococcus aureus infection_Homo sapiens_hsa051502.26582108
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26422498
18Amphetamine addiction_Homo sapiens_hsa050312.23335860
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12719333
20Pertussis_Homo sapiens_hsa051332.09217940
21Salivary secretion_Homo sapiens_hsa049702.08972873
22Dopaminergic synapse_Homo sapiens_hsa047282.01349180
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92875872
24Gastric acid secretion_Homo sapiens_hsa049711.92654892
25Cholinergic synapse_Homo sapiens_hsa047251.92586634
26Insulin secretion_Homo sapiens_hsa049111.87642447
27Malaria_Homo sapiens_hsa051441.85251561
28Tuberculosis_Homo sapiens_hsa051521.83608938
29Leishmaniasis_Homo sapiens_hsa051401.81486818
30Nitrogen metabolism_Homo sapiens_hsa009101.78228802
31Salmonella infection_Homo sapiens_hsa051321.77332576
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76067211
33TNF signaling pathway_Homo sapiens_hsa046681.75691462
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.69312690
35Cocaine addiction_Homo sapiens_hsa050301.66033414
36Oxytocin signaling pathway_Homo sapiens_hsa049211.65446776
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63033554
38Renin secretion_Homo sapiens_hsa049241.60382854
39Asthma_Homo sapiens_hsa053101.56916725
40Calcium signaling pathway_Homo sapiens_hsa040201.49436279
41Long-term depression_Homo sapiens_hsa047301.48772664
42GnRH signaling pathway_Homo sapiens_hsa049121.48217618
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44003756
44Gap junction_Homo sapiens_hsa045401.40626356
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39577589
46Legionellosis_Homo sapiens_hsa051341.38967025
47Taste transduction_Homo sapiens_hsa047421.38364475
48Allograft rejection_Homo sapiens_hsa053301.37476572
49Type II diabetes mellitus_Homo sapiens_hsa049301.34507071
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34149724
51Phagosome_Homo sapiens_hsa041451.33890807
52Serotonergic synapse_Homo sapiens_hsa047261.33443424
53Glioma_Homo sapiens_hsa052141.31453986
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28945198
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28136934
56Estrogen signaling pathway_Homo sapiens_hsa049151.27607618
57cAMP signaling pathway_Homo sapiens_hsa040241.26366904
58Graft-versus-host disease_Homo sapiens_hsa053321.20651174
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18688600
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.13369895
61Toxoplasmosis_Homo sapiens_hsa051451.13073212
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12744443
63Sphingolipid metabolism_Homo sapiens_hsa006001.12038174
64Bladder cancer_Homo sapiens_hsa052191.10979867
65Complement and coagulation cascades_Homo sapiens_hsa046101.09720492
66Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09654054
67ErbB signaling pathway_Homo sapiens_hsa040121.06397159
68* Axon guidance_Homo sapiens_hsa043601.05689537
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05227793
70cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04149067
71Melanogenesis_Homo sapiens_hsa049161.01605829
72Dorso-ventral axis formation_Homo sapiens_hsa043200.98270202
73Mineral absorption_Homo sapiens_hsa049780.97577553
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.97217890
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94122184
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92841110
77Vitamin B6 metabolism_Homo sapiens_hsa007500.91967622
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90864830
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89842177
80Dilated cardiomyopathy_Homo sapiens_hsa054140.88709348
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.88450012
82Amoebiasis_Homo sapiens_hsa051460.88228897
83Autoimmune thyroid disease_Homo sapiens_hsa053200.87533574
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.80480185
85Antigen processing and presentation_Homo sapiens_hsa046120.79766284
86VEGF signaling pathway_Homo sapiens_hsa043700.78925551
87Collecting duct acid secretion_Homo sapiens_hsa049660.78702518
88Oocyte meiosis_Homo sapiens_hsa041140.78424325
89Thyroid hormone synthesis_Homo sapiens_hsa049180.77951892
90Influenza A_Homo sapiens_hsa051640.77812799
91Shigellosis_Homo sapiens_hsa051310.77499261
92Bile secretion_Homo sapiens_hsa049760.76953564
93Pancreatic secretion_Homo sapiens_hsa049720.76210749
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75854277
95Cardiac muscle contraction_Homo sapiens_hsa042600.73683901
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.73105413
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72731680
98MAPK signaling pathway_Homo sapiens_hsa040100.71303947
99Choline metabolism in cancer_Homo sapiens_hsa052310.71263464
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70412324
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68630322
102mTOR signaling pathway_Homo sapiens_hsa041500.67590024
103Rap1 signaling pathway_Homo sapiens_hsa040150.67233733
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66779465
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65631875
106Hepatitis C_Homo sapiens_hsa051600.65336999
107B cell receptor signaling pathway_Homo sapiens_hsa046620.64642369
108Endocytosis_Homo sapiens_hsa041440.64050627
109Non-small cell lung cancer_Homo sapiens_hsa052230.62329663
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61892614
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.61700772
112Glucagon signaling pathway_Homo sapiens_hsa049220.58928034
113Ras signaling pathway_Homo sapiens_hsa040140.58738238
114Endometrial cancer_Homo sapiens_hsa052130.58674040
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58646837
116Renal cell carcinoma_Homo sapiens_hsa052110.56878479
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56357775
118Hematopoietic cell lineage_Homo sapiens_hsa046400.55075884
119Apoptosis_Homo sapiens_hsa042100.54849035
120Notch signaling pathway_Homo sapiens_hsa043300.54160508
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53848560
122HIF-1 signaling pathway_Homo sapiens_hsa040660.53798232
123PPAR signaling pathway_Homo sapiens_hsa033200.53480008
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53368293
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52923345
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52135332
127Prion diseases_Homo sapiens_hsa050200.52042628
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51881807
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51451373
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50993638
131Vibrio cholerae infection_Homo sapiens_hsa051100.50735001
132Insulin signaling pathway_Homo sapiens_hsa049100.50710515
133Arginine biosynthesis_Homo sapiens_hsa002200.49320450
134Prolactin signaling pathway_Homo sapiens_hsa049170.48947239
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48095992
136Chemokine signaling pathway_Homo sapiens_hsa040620.47164924
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46915637
138Inositol phosphate metabolism_Homo sapiens_hsa005620.44911762
139Alcoholism_Homo sapiens_hsa050340.43342668
140Acute myeloid leukemia_Homo sapiens_hsa052210.40764706
141Ovarian steroidogenesis_Homo sapiens_hsa049130.40591489
142African trypanosomiasis_Homo sapiens_hsa051430.40523020
143T cell receptor signaling pathway_Homo sapiens_hsa046600.40275556
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40146913
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39794368
146Type I diabetes mellitus_Homo sapiens_hsa049400.39060016
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38706085
148Platelet activation_Homo sapiens_hsa046110.38579017
149Hepatitis B_Homo sapiens_hsa051610.37606550
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.37232077
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.35908206
152Viral myocarditis_Homo sapiens_hsa054160.35128872
153Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33054203
154Jak-STAT signaling pathway_Homo sapiens_hsa046300.32407314
155Phototransduction_Homo sapiens_hsa047440.32364527
156Galactose metabolism_Homo sapiens_hsa000520.31622959
157Wnt signaling pathway_Homo sapiens_hsa043100.31370837
158Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31310866

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