SEMA6D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.83090921
2central nervous system myelination (GO:0022010)4.83090921
3pyrimidine nucleobase catabolic process (GO:0006208)4.80811891
4postsynaptic membrane organization (GO:0001941)4.79143068
5nucleobase catabolic process (GO:0046113)4.26448661
6L-amino acid import (GO:0043092)4.03520141
7locomotory exploration behavior (GO:0035641)3.80638377
8axon ensheathment (GO:0008366)3.72536370
9ensheathment of neurons (GO:0007272)3.72536370
10myelination (GO:0042552)3.67715531
11protein localization to synapse (GO:0035418)3.65083879
12neuron cell-cell adhesion (GO:0007158)3.58237428
13peripheral nervous system axon ensheathment (GO:0032292)3.48301773
14myelination in peripheral nervous system (GO:0022011)3.48301773
15amino acid import (GO:0043090)3.47874535
16peptidyl-tyrosine autophosphorylation (GO:0038083)3.47436954
17negative regulation of cytosolic calcium ion concentration (GO:0051481)3.46519290
18neuronal action potential propagation (GO:0019227)3.46334165
19dendrite morphogenesis (GO:0048813)3.30399281
20positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.28678018
21negative regulation of protein localization to cell surface (GO:2000009)3.26780704
22cerebellar granule cell differentiation (GO:0021707)3.25413221
23presynaptic membrane assembly (GO:0097105)3.19062097
24transmission of nerve impulse (GO:0019226)3.15008048
25positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.09080152
26gamma-aminobutyric acid transport (GO:0015812)3.08287483
27presynaptic membrane organization (GO:0097090)3.05709102
28acrosome assembly (GO:0001675)3.04605822
29central nervous system projection neuron axonogenesis (GO:0021952)3.03136069
30calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.01646501
31negative regulation of neurotransmitter secretion (GO:0046929)2.95952279
32positive regulation of synapse assembly (GO:0051965)2.93970438
33synaptic vesicle maturation (GO:0016188)2.93503474
34vocalization behavior (GO:0071625)2.89534853
35negative regulation of neurotransmitter transport (GO:0051589)2.89453585
36potassium ion import (GO:0010107)2.88982222
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88816340
38auditory behavior (GO:0031223)2.88214116
39negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85626590
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.84983884
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.83535967
42cerebral cortex radially oriented cell migration (GO:0021799)2.83288862
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.82883664
44dendritic spine morphogenesis (GO:0060997)2.82849605
45negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82391714
46ionotropic glutamate receptor signaling pathway (GO:0035235)2.81589686
47neuron recognition (GO:0008038)2.80935555
48axonal fasciculation (GO:0007413)2.80381554
49layer formation in cerebral cortex (GO:0021819)2.77704288
50positive regulation of neurotransmitter secretion (GO:0001956)2.76886527
51neuronal ion channel clustering (GO:0045161)2.76520905
52glycosphingolipid biosynthetic process (GO:0006688)2.75634394
53regulation of short-term neuronal synaptic plasticity (GO:0048172)2.74873259
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73414621
55neuronal action potential (GO:0019228)2.72806840
56establishment of mitochondrion localization (GO:0051654)2.71576041
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.71146227
58response to auditory stimulus (GO:0010996)2.70404131
59regulation of synapse assembly (GO:0051963)2.66964628
60nerve growth factor signaling pathway (GO:0038180)2.66315248
61cellular potassium ion homeostasis (GO:0030007)2.65987796
62behavioral response to ethanol (GO:0048149)2.65639636
63glutamate receptor signaling pathway (GO:0007215)2.63424541
64regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.60119588
65central nervous system neuron axonogenesis (GO:0021955)2.58599655
66retinal ganglion cell axon guidance (GO:0031290)2.57670050
67glutamate secretion (GO:0014047)2.55896086
68regulation of synaptic transmission, GABAergic (GO:0032228)2.55779134
69regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.55760356
70gamma-aminobutyric acid signaling pathway (GO:0007214)2.55689782
71positive regulation of neurotransmitter transport (GO:0051590)2.54588712
72exploration behavior (GO:0035640)2.54264452
73semaphorin-plexin signaling pathway (GO:0071526)2.52992675
74membrane assembly (GO:0071709)2.51924501
75response to histamine (GO:0034776)2.51874753
76cell communication involved in cardiac conduction (GO:0086065)2.51727697
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.51550836
78neuromuscular synaptic transmission (GO:0007274)2.51304821
79regulation of axon extension involved in axon guidance (GO:0048841)2.50745091
80membrane depolarization during action potential (GO:0086010)2.50009457
81synaptic vesicle exocytosis (GO:0016079)2.47865107
82sodium ion export (GO:0071436)2.47691815
83neurotransmitter catabolic process (GO:0042135)2.47098681
84adult walking behavior (GO:0007628)2.46643912
85negative regulation of axon extension (GO:0030517)2.45958793
86oligodendrocyte differentiation (GO:0048709)2.45298481
87synaptic transmission, glutamatergic (GO:0035249)2.44785425
88positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.44216565
89adhesion of symbiont to host cell (GO:0044650)2.43712629
90virion attachment to host cell (GO:0019062)2.43712629
91neurotransmitter secretion (GO:0007269)2.43194883
92regulation of glutamate receptor signaling pathway (GO:1900449)2.42536475
93cellular sodium ion homeostasis (GO:0006883)2.42471702
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.39797597
95glycine transport (GO:0015816)2.38948111
96regulation of respiratory system process (GO:0044065)2.38870847
97negative regulation of Rho protein signal transduction (GO:0035024)2.38749758
98eye photoreceptor cell differentiation (GO:0001754)2.38089996
99photoreceptor cell differentiation (GO:0046530)2.38089996
100startle response (GO:0001964)2.37600711
101action potential (GO:0001508)2.37449136
102establishment of nucleus localization (GO:0040023)2.37071099
103C4-dicarboxylate transport (GO:0015740)2.37021595
104regulation of dendritic spine development (GO:0060998)2.36879885
105regulation of pigment cell differentiation (GO:0050932)2.36266631
106positive regulation of synapse maturation (GO:0090129)2.36150213
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.35075547
108regulation of cardiac muscle cell contraction (GO:0086004)2.34281974
109negative regulation of axonogenesis (GO:0050771)2.33926618
110synapse assembly (GO:0007416)2.33484873
111regulation of axon guidance (GO:1902667)2.33092145
112behavioral response to nicotine (GO:0035095)2.32166212
113regulation of synaptic vesicle exocytosis (GO:2000300)2.32165533
114acidic amino acid transport (GO:0015800)2.31720841
115cochlea development (GO:0090102)2.31681922
116G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.31338204
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.31089245
118fatty acid elongation (GO:0030497)2.30917973
119regulation of synaptic vesicle transport (GO:1902803)2.30741245
120regulation of cell communication by electrical coupling (GO:0010649)2.30670174
121positive regulation of potassium ion transmembrane transport (GO:1901381)2.28541596
122synapse organization (GO:0050808)2.27090771
123potassium ion homeostasis (GO:0055075)2.26974509
124cerebellar Purkinje cell differentiation (GO:0021702)2.26953225
125regulation of voltage-gated calcium channel activity (GO:1901385)2.26603969
126cell migration in hindbrain (GO:0021535)2.26447284
127cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.26158271
128neurotransmitter-gated ion channel clustering (GO:0072578)2.25686693
129long-chain fatty acid biosynthetic process (GO:0042759)2.25310220
130mechanosensory behavior (GO:0007638)2.25238368
131regulation of dendritic spine morphogenesis (GO:0061001)2.24691637
132proline transport (GO:0015824)2.22877830
133astrocyte development (GO:0014002)2.22499698
134neuron remodeling (GO:0016322)2.22149411
135cell communication by electrical coupling (GO:0010644)2.21905480
136neuron-neuron synaptic transmission (GO:0007270)2.21536995
137L-glutamate transport (GO:0015813)2.21186794
138cell differentiation in hindbrain (GO:0021533)2.20823012
139positive regulation of potassium ion transport (GO:0043268)2.20439826
140negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.20405649
141neurotransmitter uptake (GO:0001504)2.20046714
142regulation of synapse structural plasticity (GO:0051823)2.19653514
143regulation of synaptic transmission, glutamatergic (GO:0051966)2.17175517
144regulation of neuronal synaptic plasticity (GO:0048168)2.16283419
145membrane hyperpolarization (GO:0060081)2.15057519
146regulation of long-term neuronal synaptic plasticity (GO:0048169)2.14400533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.02705988
2GBX2_23144817_ChIP-Seq_PC3_Human2.86830394
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62754697
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52583863
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.43867161
6* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29724921
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27863273
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27863273
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25968084
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21577648
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16253300
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.12111265
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.08011749
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07024191
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06091677
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.03965276
17AR_21572438_ChIP-Seq_LNCaP_Human2.03125390
18DROSHA_22980978_ChIP-Seq_HELA_Human2.02556578
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00166081
20FUS_26573619_Chip-Seq_HEK293_Human1.94305242
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.86697183
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.84432143
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80465764
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74503326
25* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73449820
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72212343
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69237200
28IGF1R_20145208_ChIP-Seq_DFB_Human1.68574860
29VDR_22108803_ChIP-Seq_LS180_Human1.64807533
30ZNF274_21170338_ChIP-Seq_K562_Hela1.58682737
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57368876
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.55473462
33RNF2_27304074_Chip-Seq_NSC_Mouse1.53649910
34TAF15_26573619_Chip-Seq_HEK293_Human1.53258356
35* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53106642
36* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51672208
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50614311
38* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50298353
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49417985
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49165647
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.47179214
42EWS_26573619_Chip-Seq_HEK293_Human1.45285690
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.44850250
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.44533515
45P300_19829295_ChIP-Seq_ESCs_Human1.44028575
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.43094176
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.43077162
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42883073
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41942354
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40034951
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39279086
52* REST_21632747_ChIP-Seq_MESCs_Mouse1.39068335
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.34983257
54AHR_22903824_ChIP-Seq_MCF-7_Human1.34093816
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33005815
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32405637
57* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32366605
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31004188
59* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29323860
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28533964
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27204549
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26963163
63* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26320901
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24134199
65TP53_18474530_ChIP-ChIP_U2OS_Human1.24052361
66* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23957021
67TP53_16413492_ChIP-PET_HCT116_Human1.23069146
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22876436
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.22717169
70* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20470027
71STAT3_23295773_ChIP-Seq_U87_Human1.19707072
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18120033
73KDM2B_26808549_Chip-Seq_REH_Human1.16447998
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.16081504
75* SOX2_21211035_ChIP-Seq_LN229_Gbm1.15467221
76* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15444751
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.15437065
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15121758
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13508766
80* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13401867
81* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11672216
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11393223
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11143542
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10453314
85CBP_20019798_ChIP-Seq_JUKART_Human1.10453314
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09862490
87* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09461154
88* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09461154
89* ER_23166858_ChIP-Seq_MCF-7_Human1.09131966
90* P53_22387025_ChIP-Seq_ESCs_Mouse1.07306841
91* AR_25329375_ChIP-Seq_VCAP_Human1.05807088
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.05792676
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.05480534
94* SMAD4_21741376_ChIP-Seq_HESCs_Human1.05431347
95TCF4_23295773_ChIP-Seq_U87_Human1.04932293
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04900636
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04549932
98RXR_22108803_ChIP-Seq_LS180_Human1.01909561
99AR_19668381_ChIP-Seq_PC3_Human1.01607293
100* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01178979
101* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01178979
102RUNX2_22187159_ChIP-Seq_PCA_Human1.01141064
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99964685
104* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98613182
105* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97959414
106* REST_18959480_ChIP-ChIP_MESCs_Mouse0.97433229
107* NANOG_18555785_Chip-Seq_ESCs_Mouse0.96166579
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95433888
109YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95112933
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94746240
111PRDM14_20953172_ChIP-Seq_ESCs_Human0.94580967
112BCAT_22108803_ChIP-Seq_LS180_Human0.94047532
113P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93313985
114WT1_19549856_ChIP-ChIP_CCG9911_Human0.93260809
115* SMAD3_21741376_ChIP-Seq_HESCs_Human0.93120861
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92516488
117VDR_24787735_ChIP-Seq_THP-1_Human0.92420722
118* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92099318
119SMAD4_21741376_ChIP-Seq_EPCs_Human0.90998324
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90039022
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87222288
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.87158490
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.86999769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.71665676
2MP0003880_abnormal_central_pattern3.23988803
3MP0000920_abnormal_myelination2.99598773
4MP0004270_analgesia2.98515994
5MP0005423_abnormal_somatic_nervous2.80918311
6MP0005171_absent_coat_pigmentation2.71329174
7MP0003635_abnormal_synaptic_transmissio2.69163193
8MP0009046_muscle_twitch2.64697582
9MP0003690_abnormal_glial_cell2.61371747
10MP0004272_abnormal_basement_membrane2.49142970
11MP0005623_abnormal_meninges_morphology2.48986472
12MP0001486_abnormal_startle_reflex2.47630733
13MP0000778_abnormal_nervous_system2.43180727
14MP0002064_seizures2.40399689
15MP0009745_abnormal_behavioral_response2.32200458
16MP0004885_abnormal_endolymph2.27027891
17MP0002272_abnormal_nervous_system2.26817321
18MP0002734_abnormal_mechanical_nocicepti2.13312225
19MP0004858_abnormal_nervous_system2.07689713
20MP0002063_abnormal_learning/memory/cond1.97554639
21MP0002572_abnormal_emotion/affect_behav1.88187072
22MP0003634_abnormal_glial_cell1.86983623
23MP0002102_abnormal_ear_morphology1.85200239
24MP0001968_abnormal_touch/_nociception1.82610934
25MP0001879_abnormal_lymphatic_vessel1.75220388
26MP0005167_abnormal_blood-brain_barrier1.71062622
27MP0002067_abnormal_sensory_capabilities1.70227044
28MP0001440_abnormal_grooming_behavior1.69079399
29MP0003136_yellow_coat_color1.66381120
30MP0008569_lethality_at_weaning1.63861230
31MP0002733_abnormal_thermal_nociception1.59117850
32MP0003329_amyloid_beta_deposits1.58985288
33MP0009780_abnormal_chondrocyte_physiolo1.55951472
34MP0001188_hyperpigmentation1.51584356
35MP0003646_muscle_fatigue1.47285225
36MP0001905_abnormal_dopamine_level1.46642937
37MP0001970_abnormal_pain_threshold1.46407330
38MP0010368_abnormal_lymphatic_system1.45495692
39MP0005187_abnormal_penis_morphology1.44911409
40MP0004147_increased_porphyrin_level1.44202334
41MP0004742_abnormal_vestibular_system1.43804272
42MP0002184_abnormal_innervation1.40844083
43MP0003121_genomic_imprinting1.40025120
44MP0001501_abnormal_sleep_pattern1.39740811
45MP0003632_abnormal_nervous_system1.38920311
46MP0000751_myopathy1.35826053
47MP0001485_abnormal_pinna_reflex1.35678157
48MP0004924_abnormal_behavior1.35236256
49MP0005386_behavior/neurological_phenoty1.35236256
50MP0003633_abnormal_nervous_system1.34341363
51MP0003631_nervous_system_phenotype1.31525953
52MP0005409_darkened_coat_color1.31384474
53MP0002882_abnormal_neuron_morphology1.30311904
54MP0000955_abnormal_spinal_cord1.29908270
55MP0004510_myositis1.28218173
56MP0002254_reproductive_system_inflammat1.27206533
57MP0001346_abnormal_lacrimal_gland1.23976903
58MP0002909_abnormal_adrenal_gland1.23176930
59MP0001299_abnormal_eye_distance/1.22455317
60MP0004142_abnormal_muscle_tone1.22143695
61MP0004043_abnormal_pH_regulation1.21508969
62MP0005645_abnormal_hypothalamus_physiol1.20966238
63MP0002735_abnormal_chemical_nociception1.20138347
64MP0003787_abnormal_imprinting1.19919851
65MP0003119_abnormal_digestive_system1.18990639
66MP0005646_abnormal_pituitary_gland1.18357125
67MP0002822_catalepsy1.16101488
68MP0002066_abnormal_motor_capabilities/c1.15788048
69MP0002736_abnormal_nociception_after1.14929351
70MP0002557_abnormal_social/conspecific_i1.14015505
71MP0003045_fibrosis1.13448965
72MP0004145_abnormal_muscle_electrophysio1.12724867
73MP0001502_abnormal_circadian_rhythm1.12532608
74MP0000534_abnormal_ureter_morphology1.11372220
75MP0004133_heterotaxia1.09012920
76MP0000569_abnormal_digit_pigmentation1.08667377
77MP0006276_abnormal_autonomic_nervous1.05259479
78MP0006138_congestive_heart_failure1.04309097
79MP0005085_abnormal_gallbladder_physiolo1.03963063
80MP0004215_abnormal_myocardial_fiber1.02895951
81MP0005253_abnormal_eye_physiology1.02139965
82MP0005248_abnormal_Harderian_gland1.00791591
83MP0001348_abnormal_lacrimal_gland1.00767259
84MP0002751_abnormal_autonomic_nervous0.98388505
85MP0003950_abnormal_plasma_membrane0.98214062
86MP0000516_abnormal_urinary_system0.97790410
87MP0005367_renal/urinary_system_phenotyp0.97790410
88MP0001529_abnormal_vocalization0.97771339
89MP0000026_abnormal_inner_ear0.97278421
90MP0002152_abnormal_brain_morphology0.96748626
91MP0005499_abnormal_olfactory_system0.96235352
92MP0005394_taste/olfaction_phenotype0.96235352
93MP0003122_maternal_imprinting0.95346758
94MP0004811_abnormal_neuron_physiology0.93586799
95MP0003137_abnormal_impulse_conducting0.93579091
96MP0002233_abnormal_nose_morphology0.92982009
97MP0000631_abnormal_neuroendocrine_gland0.92312412
98MP0004085_abnormal_heartbeat0.90373893
99MP0003861_abnormal_nervous_system0.90345732
100MP0002163_abnormal_gland_morphology0.90166751
101MP0003890_abnormal_embryonic-extraembry0.88232307
102MP0002229_neurodegeneration0.87131560
103MP0004134_abnormal_chest_morphology0.84092929
104MP0009384_cardiac_valve_regurgitation0.83700757
105MP0000049_abnormal_middle_ear0.82610492
106MP0002638_abnormal_pupillary_reflex0.82389558
107MP0000604_amyloidosis0.82149998
108MP0002752_abnormal_somatic_nervous0.81847478
109MP0003868_abnormal_feces_composition0.80848212
110MP0000566_synostosis0.80804511
111MP0001177_atelectasis0.80405926
112MP0001664_abnormal_digestion0.80032540
113MP0005360_urolithiasis0.79829495
114MP0008789_abnormal_olfactory_epithelium0.79174920
115MP0003283_abnormal_digestive_organ0.77609358
116MP0003091_abnormal_cell_migration0.77133231
117MP0001986_abnormal_taste_sensitivity0.77057440
118MP0000372_irregular_coat_pigmentation0.76896839
119MP0002069_abnormal_eating/drinking_beha0.76772913
120MP0008775_abnormal_heart_ventricle0.76298183
121MP0000749_muscle_degeneration0.75992390
122MP0005551_abnormal_eye_electrophysiolog0.75904083
123MP0000013_abnormal_adipose_tissue0.74929239
124MP0001984_abnormal_olfaction0.74249555
125MP0002295_abnormal_pulmonary_circulatio0.73651866
126MP0002972_abnormal_cardiac_muscle0.73042978
127MP0001963_abnormal_hearing_physiology0.72421055
128MP0005379_endocrine/exocrine_gland_phen0.68891019
129MP0002090_abnormal_vision0.67194054
130MP0005620_abnormal_muscle_contractility0.66339809
131MP0010678_abnormal_skin_adnexa0.63776720
132MP0005595_abnormal_vascular_smooth0.63654774
133MP0000462_abnormal_digestive_system0.63543993
134MP0002938_white_spotting0.63089692
135MP0003385_abnormal_body_wall0.62713411

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)5.14041745
2Ulnar claw (HP:0001178)4.56069021
3Insidious onset (HP:0003587)4.08216433
4Termporal pattern (HP:0011008)4.08216433
5Segmental peripheral demyelination/remyelination (HP:0003481)3.87449966
6Neurofibrillary tangles (HP:0002185)3.71979434
7Peripheral hypomyelination (HP:0007182)3.69984561
8Onion bulb formation (HP:0003383)3.61780453
9Focal motor seizures (HP:0011153)3.43730045
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.36391155
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.36391155
12Abnormality of the corticospinal tract (HP:0002492)3.34847870
13Myokymia (HP:0002411)3.33918990
14Chorioretinal atrophy (HP:0000533)3.18561988
15Hemiparesis (HP:0001269)3.17906821
16Focal seizures (HP:0007359)3.16041892
17Hemiplegia (HP:0002301)3.13528634
18Aplasia involving bones of the extremities (HP:0009825)3.12789199
19Aplasia involving bones of the upper limbs (HP:0009823)3.12789199
20Aplasia of the phalanges of the hand (HP:0009802)3.12789199
21Progressive cerebellar ataxia (HP:0002073)3.03030605
22Atonic seizures (HP:0010819)3.01950052
23Supranuclear gaze palsy (HP:0000605)2.99794170
24Megalencephaly (HP:0001355)2.99444962
25Absent speech (HP:0001344)2.89214439
26Intention tremor (HP:0002080)2.84233304
27Steppage gait (HP:0003376)2.79941990
28Alacrima (HP:0000522)2.77327136
29Hepatoblastoma (HP:0002884)2.75996238
30Papillary thyroid carcinoma (HP:0002895)2.72356049
31Genital tract atresia (HP:0001827)2.67215778
32Pheochromocytoma (HP:0002666)2.65775323
33Dysmetria (HP:0001310)2.64264023
34Epileptic encephalopathy (HP:0200134)2.62518162
35Cerebral inclusion bodies (HP:0100314)2.62393728
36Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.53542383
37Postural tremor (HP:0002174)2.49826648
38Spastic gait (HP:0002064)2.49614827
39Hammertoe (HP:0001765)2.49276949
40Cerebral hemorrhage (HP:0001342)2.47389712
41Lower limb muscle weakness (HP:0007340)2.46884450
42Gait imbalance (HP:0002141)2.45494076
43Adactyly (HP:0009776)2.44503621
44Renal hypoplasia (HP:0000089)2.42086937
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.41034829
46Sensory axonal neuropathy (HP:0003390)2.39579282
47Neuroendocrine neoplasm (HP:0100634)2.35938948
48Split foot (HP:0001839)2.35611080
49Retinal dysplasia (HP:0007973)2.34442446
50Anteriorly placed anus (HP:0001545)2.32012243
51Bifid tongue (HP:0010297)2.29874484
52Amyotrophic lateral sclerosis (HP:0007354)2.28829586
53Ankle clonus (HP:0011448)2.28479332
54Vaginal atresia (HP:0000148)2.26229344
55Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.24478588
56Exotropia (HP:0000577)2.23654839
57Pachygyria (HP:0001302)2.23366555
58Gaze-evoked nystagmus (HP:0000640)2.20535469
59Scanning speech (HP:0002168)2.18860041
60Decreased lacrimation (HP:0000633)2.17925368
61Abnormality of binocular vision (HP:0011514)2.15950043
62Diplopia (HP:0000651)2.15950043
63Decreased motor nerve conduction velocity (HP:0003431)2.14957848
64Blue irides (HP:0000635)2.14757976
65Hypoplasia of the iris (HP:0007676)2.14740660
66Dysdiadochokinesis (HP:0002075)2.14317501
67Congenital sensorineural hearing impairment (HP:0008527)2.12295356
68Short tibia (HP:0005736)2.11504292
69Aqueductal stenosis (HP:0002410)2.10864294
70Broad metatarsal (HP:0001783)2.09564288
71Thickened helices (HP:0000391)2.06622194
72Febrile seizures (HP:0002373)2.06315127
73Broad-based gait (HP:0002136)2.04313280
74Limb dystonia (HP:0002451)2.04191981
75Intestinal atresia (HP:0011100)2.03824999
76Amblyopia (HP:0000646)2.03049248
77Protruding tongue (HP:0010808)2.02889069
78Urinary bladder sphincter dysfunction (HP:0002839)2.02431931
79Congenital primary aphakia (HP:0007707)2.00000582
80Inability to walk (HP:0002540)1.99601697
81Medial flaring of the eyebrow (HP:0010747)1.99352232
82Epileptiform EEG discharges (HP:0011182)1.98535800
83Hyperventilation (HP:0002883)1.96491827
84Synostosis involving the elbow (HP:0003938)1.95776978
85Humeroradial synostosis (HP:0003041)1.95776978
86Thyroid carcinoma (HP:0002890)1.95207321
87Abnormal eating behavior (HP:0100738)1.95106421
88Absent hand (HP:0004050)1.94920277
89Metabolic alkalosis (HP:0200114)1.94370202
90Abnormality of macular pigmentation (HP:0008002)1.93144770
91Truncal ataxia (HP:0002078)1.92516548
92Nephrogenic diabetes insipidus (HP:0009806)1.91603484
93Abnormal auditory evoked potentials (HP:0006958)1.91131673
94Foot dorsiflexor weakness (HP:0009027)1.90720220
95Hypsarrhythmia (HP:0002521)1.90686450
96EEG with generalized epileptiform discharges (HP:0011198)1.90366717
97Syncope (HP:0001279)1.89432672
98Midline defect of the nose (HP:0004122)1.87452621
99Abnormality of the lower motor neuron (HP:0002366)1.86739061
100Mutism (HP:0002300)1.86630978
101Coronal craniosynostosis (HP:0004440)1.86614738
102Increased circulating renin level (HP:0000848)1.86297118
103Anterior segment dysgenesis (HP:0007700)1.86151423
104Absence seizures (HP:0002121)1.85593913
105Neoplasm of the oral cavity (HP:0100649)1.85213900
106Prolonged QT interval (HP:0001657)1.84231404
107Parakeratosis (HP:0001036)1.84194908
108Specific learning disability (HP:0001328)1.83521113
109Slow saccadic eye movements (HP:0000514)1.83161939
110Aplasia cutis congenita (HP:0001057)1.83085072
111Akinesia (HP:0002304)1.83081845
112Clumsiness (HP:0002312)1.82887482
113Medulloblastoma (HP:0002885)1.81887540
114Impaired proprioception (HP:0010831)1.80819227
115Chronic hepatic failure (HP:0100626)1.79072995
116Generalized tonic-clonic seizures (HP:0002069)1.78916052
117Peripheral demyelination (HP:0011096)1.78552929
118Abnormality of the astrocytes (HP:0100707)1.78080175
119Astrocytoma (HP:0009592)1.78080175
120Hypoplastic left heart (HP:0004383)1.77956734
121Renal dysplasia (HP:0000110)1.77791302
122Abnormality of the parathyroid morphology (HP:0011766)1.77675151
123Progressive inability to walk (HP:0002505)1.77528593
124Widely spaced teeth (HP:0000687)1.76943608
125Abnormality of the foot musculature (HP:0001436)1.76523550
126Cutaneous finger syndactyly (HP:0010554)1.76120540
127Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74939894
128Neoplasm of the heart (HP:0100544)1.74802772
129Macroorchidism (HP:0000053)1.72714416
130Impaired vibration sensation in the lower limbs (HP:0002166)1.72326050
131Preaxial foot polydactyly (HP:0001841)1.71468070
132Abnormality of the calf musculature (HP:0001430)1.69371012
133Cupped ear (HP:0000378)1.68819205
134Dialeptic seizures (HP:0011146)1.68758391
135Torticollis (HP:0000473)1.67109667
136Lissencephaly (HP:0001339)1.66892674
137Pancreatic fibrosis (HP:0100732)1.66228479
138Distal sensory impairment (HP:0002936)1.65511874
139Fair hair (HP:0002286)1.65457277
140Difficulty running (HP:0009046)1.64301607
141Pulmonary artery stenosis (HP:0004415)1.64069347
142Abnormality of salivation (HP:0100755)1.63515667
143Confusion (HP:0001289)1.62923698
144Epidermoid cyst (HP:0200040)1.62672459
145Drooling (HP:0002307)1.62368029
146Excessive salivation (HP:0003781)1.62368029
147Broad ribs (HP:0000885)1.62272131
148Gastrointestinal atresia (HP:0002589)1.61660106
149Postural instability (HP:0002172)1.60801313
150Cortical dysplasia (HP:0002539)1.60585795
151Genetic anticipation (HP:0003743)1.60500934
152Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59928419
153Increased CSF protein (HP:0002922)1.59886385
154Urinary urgency (HP:0000012)1.59760620
155Polyphagia (HP:0002591)1.59634835
156Abnormal biliary tract morphology (HP:0012440)1.59598542
157Abnormal ciliary motility (HP:0012262)1.59592631
158Abnormality of the aortic arch (HP:0012303)1.59426148
159Abnormality of calcium-phosphate metabolism (HP:0100530)1.58776927
160Fetal akinesia sequence (HP:0001989)1.58744208
161Spastic tetraplegia (HP:0002510)1.58021050
162Short hallux (HP:0010109)1.58013406
163Absent eyebrow (HP:0002223)1.57915803
164Anxiety (HP:0000739)1.57694666
165Cutaneous syndactyly (HP:0012725)1.56494189
166Intellectual disability, severe (HP:0010864)1.55779022
167Abnormality of the ischium (HP:0003174)1.55596707
168Hypoplasia of the corpus callosum (HP:0002079)1.55147540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.37082210
2STK393.24617793
3FRK2.82153195
4WNK32.56707308
5MARK12.40331397
6EPHB12.34220627
7NTRK22.26093856
8NTRK32.09009065
9FGFR22.00070745
10BCR1.99053478
11EPHA41.97822834
12TAF11.96888526
13OXSR11.95490447
14PKN11.95402426
15NTRK11.92495213
16WNK11.82383539
17PAK61.79866301
18MAPK131.68848850
19IRAK21.63027287
20ACVR1B1.62746454
21PHKG11.60894686
22PHKG21.60894686
23MAP3K41.57644007
24CASK1.56936695
25PINK11.56577709
26TYRO31.56038899
27TIE11.53804037
28OBSCN1.48847074
29ERBB31.35490107
30MAP4K21.32725513
31INSRR1.30816659
32PAK31.29406101
33UHMK11.28189675
34WNK41.27271674
35DYRK21.27179689
36TRIM281.25522997
37MAP3K131.24041771
38ICK1.23123679
39MINK11.21784633
40CDK51.19207911
41FGR1.18337659
42PRPF4B1.17264333
43CAMK1G1.17128826
44MAP2K71.15414322
45SGK4941.11378165
46SGK2231.11378165
47PTK2B1.11051535
48KDR1.10820366
49EPHB21.09333754
50NEK61.06681733
51DMPK1.05637902
52ROCK21.03800072
53IRAK11.03451666
54PNCK1.00902142
55MUSK1.00403632
56MKNK20.98376582
57LMTK20.97877724
58PRKD30.97510096
59MAP3K90.94478955
60CAMK2A0.94232724
61CSNK1G20.93241696
62RET0.92957548
63PRKCE0.90944414
64CSNK1A1L0.90730461
65STK110.89697733
66ROCK10.89096742
67PRKCH0.86638302
68DAPK20.84222824
69MAP2K40.83484989
70MAP3K140.82983867
71CAMK2D0.80336945
72RIPK10.80259796
73FES0.79464791
74PRKCQ0.78968720
75MARK20.78967547
76CAMK2B0.77634437
77DYRK1A0.76254193
78MET0.75839476
79CSNK1G30.73181989
80ADRBK20.72835516
81PLK20.72428391
82BMPR1B0.69910779
83STK38L0.69349225
84PDGFRB0.67906261
85GRK50.66047009
86PTK20.64889506
87PRKAA20.64833448
88CSNK1G10.64199266
89ERBB40.63331180
90FYN0.63301564
91SGK10.63125261
92SIK20.62897681
93PRKD10.62235725
94CAMK2G0.61980966
95CCNB10.61312455
96AKT30.60625609
97BMX0.60327703
98SGK20.59958096
99KSR20.58340808
100MAPK120.57257681
101CDC42BPA0.57153787
102PDK20.56019716
103CDK140.55827285
104PIK3CA0.55806197
105KSR10.55763827
106GRK10.53519798
107CAMK40.53053311
108DYRK30.52463583
109ERBB20.52307811
110SIK10.50500353
111JAK10.49875688
112PDGFRA0.49013049
113PRKCG0.48919219
114PRKG10.48900415
115GSK3A0.48882601
116PRKACA0.48726981
117PRKCZ0.48268722
118LIMK10.48232823
119SGK30.47623382
120MAPKAPK50.47145340
121SRC0.47086432
122RPS6KA40.46631839
123EPHA30.46011798
124CDK150.45771969
125MAP3K60.45529731
126CSNK1A10.45495716
127FER0.44755972
128MAP3K20.40766361
129CDK180.40669712
130WEE10.39079070
131PRKAA10.38763733
132CAMK10.37220525
133CSNK1D0.37049357
134CSNK1E0.36919693
135CAMKK20.33825510
136RPS6KA30.33282925
137PRKACG0.32624987
138BRD40.32552701

Predicted pathways (KEGG)

RankGene SetZ-score
1Glutamatergic synapse_Homo sapiens_hsa047242.10680027
2Nicotine addiction_Homo sapiens_hsa050332.00807955
3GABAergic synapse_Homo sapiens_hsa047271.93670311
4Nitrogen metabolism_Homo sapiens_hsa009101.77448416
5Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.77342411
6* Axon guidance_Homo sapiens_hsa043601.76584471
7Circadian entrainment_Homo sapiens_hsa047131.75336457
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69485164
9Dorso-ventral axis formation_Homo sapiens_hsa043201.64915780
10Morphine addiction_Homo sapiens_hsa050321.61257095
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58347642
12Salivary secretion_Homo sapiens_hsa049701.54081612
13Cholinergic synapse_Homo sapiens_hsa047251.45950469
14Gastric acid secretion_Homo sapiens_hsa049711.43165624
15Serotonergic synapse_Homo sapiens_hsa047261.42622262
16Long-term depression_Homo sapiens_hsa047301.37665491
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36249056
18Renin secretion_Homo sapiens_hsa049241.34372498
19Steroid biosynthesis_Homo sapiens_hsa001001.33445408
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32677889
21Histidine metabolism_Homo sapiens_hsa003401.32575290
22Cocaine addiction_Homo sapiens_hsa050301.31884315
23Dilated cardiomyopathy_Homo sapiens_hsa054141.31426382
24Insulin secretion_Homo sapiens_hsa049111.30268065
25Long-term potentiation_Homo sapiens_hsa047201.27847735
26Dopaminergic synapse_Homo sapiens_hsa047281.25869999
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25718060
28Synaptic vesicle cycle_Homo sapiens_hsa047211.25080668
29Fat digestion and absorption_Homo sapiens_hsa049751.24831873
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22350616
31Amphetamine addiction_Homo sapiens_hsa050311.21184345
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20927136
33Protein digestion and absorption_Homo sapiens_hsa049741.18624477
34Butanoate metabolism_Homo sapiens_hsa006501.17487464
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17031336
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15772481
37Olfactory transduction_Homo sapiens_hsa047401.13485215
38Taste transduction_Homo sapiens_hsa047421.10775513
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.10345572
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.09615551
41Ether lipid metabolism_Homo sapiens_hsa005651.09457321
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08143487
43cAMP signaling pathway_Homo sapiens_hsa040241.07458604
44Oxytocin signaling pathway_Homo sapiens_hsa049211.05979351
45Gap junction_Homo sapiens_hsa045401.05392116
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05263097
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05128597
48Calcium signaling pathway_Homo sapiens_hsa040201.04025753
49Fatty acid biosynthesis_Homo sapiens_hsa000611.02571959
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02524724
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01153137
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00928925
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.98973376
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.98855222
55Renin-angiotensin system_Homo sapiens_hsa046140.97815149
56Linoleic acid metabolism_Homo sapiens_hsa005910.97668748
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96887585
58African trypanosomiasis_Homo sapiens_hsa051430.96080514
59GnRH signaling pathway_Homo sapiens_hsa049120.95771885
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95606155
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93589557
62Phototransduction_Homo sapiens_hsa047440.93122253
63Propanoate metabolism_Homo sapiens_hsa006400.92214340
64ErbB signaling pathway_Homo sapiens_hsa040120.92099109
65ECM-receptor interaction_Homo sapiens_hsa045120.91613984
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90582090
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90332634
68Fatty acid elongation_Homo sapiens_hsa000620.89641834
69beta-Alanine metabolism_Homo sapiens_hsa004100.88467920
70Pancreatic secretion_Homo sapiens_hsa049720.88421716
71Ras signaling pathway_Homo sapiens_hsa040140.87397636
72ABC transporters_Homo sapiens_hsa020100.86566500
73Renal cell carcinoma_Homo sapiens_hsa052110.86011016
74Type II diabetes mellitus_Homo sapiens_hsa049300.84822018
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82501445
76Caffeine metabolism_Homo sapiens_hsa002320.81639957
77Melanogenesis_Homo sapiens_hsa049160.81609584
78PPAR signaling pathway_Homo sapiens_hsa033200.80448016
79Estrogen signaling pathway_Homo sapiens_hsa049150.79283865
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78314970
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77942008
82Focal adhesion_Homo sapiens_hsa045100.77779479
83Viral myocarditis_Homo sapiens_hsa054160.77440397
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76909993
85Bile secretion_Homo sapiens_hsa049760.76830916
86Cardiac muscle contraction_Homo sapiens_hsa042600.76658402
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76439713
88Vitamin digestion and absorption_Homo sapiens_hsa049770.75627493
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.74788943
90Rap1 signaling pathway_Homo sapiens_hsa040150.74403891
91Circadian rhythm_Homo sapiens_hsa047100.72371418
92Choline metabolism in cancer_Homo sapiens_hsa052310.72214423
93Ovarian steroidogenesis_Homo sapiens_hsa049130.70899107
94Chemokine signaling pathway_Homo sapiens_hsa040620.70449299
95MAPK signaling pathway_Homo sapiens_hsa040100.69519768
96Tryptophan metabolism_Homo sapiens_hsa003800.69500142
97Fatty acid degradation_Homo sapiens_hsa000710.69144589
98Glioma_Homo sapiens_hsa052140.66906079
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65547570
100Tight junction_Homo sapiens_hsa045300.65482368
101Glycerolipid metabolism_Homo sapiens_hsa005610.64897654
102Arginine and proline metabolism_Homo sapiens_hsa003300.64670945
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62007298
104Starch and sucrose metabolism_Homo sapiens_hsa005000.60779292
105Arginine biosynthesis_Homo sapiens_hsa002200.60762935
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60434048
107Hedgehog signaling pathway_Homo sapiens_hsa043400.59715426
108Hippo signaling pathway_Homo sapiens_hsa043900.58274137
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57818964
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57205861
111Thyroid hormone synthesis_Homo sapiens_hsa049180.57097407
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55402158
113Glucagon signaling pathway_Homo sapiens_hsa049220.55186963
114Collecting duct acid secretion_Homo sapiens_hsa049660.54230910
115Amoebiasis_Homo sapiens_hsa051460.53721286
116Retinol metabolism_Homo sapiens_hsa008300.53661141
117Endocytosis_Homo sapiens_hsa041440.53494565
118Rheumatoid arthritis_Homo sapiens_hsa053230.51907759
119TGF-beta signaling pathway_Homo sapiens_hsa043500.51856187
120Chemical carcinogenesis_Homo sapiens_hsa052040.51788264
121Allograft rejection_Homo sapiens_hsa053300.51070296
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.50782527
123Proteoglycans in cancer_Homo sapiens_hsa052050.49727478
124Graft-versus-host disease_Homo sapiens_hsa053320.49304836
125Fatty acid metabolism_Homo sapiens_hsa012120.49224056
126Prion diseases_Homo sapiens_hsa050200.48406019
127Wnt signaling pathway_Homo sapiens_hsa043100.47800814
128Vibrio cholerae infection_Homo sapiens_hsa051100.47277204
129Mineral absorption_Homo sapiens_hsa049780.46740902
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43925936
131Platelet activation_Homo sapiens_hsa046110.43781117
132Type I diabetes mellitus_Homo sapiens_hsa049400.43763646
133Autoimmune thyroid disease_Homo sapiens_hsa053200.43306571
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42998268
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42688131
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.41398657
137Adherens junction_Homo sapiens_hsa045200.41177564
138Sphingolipid metabolism_Homo sapiens_hsa006000.40754126
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40520828

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