SEMA7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.21224928
2locomotory exploration behavior (GO:0035641)5.21174191
3CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.18632632
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.79295763
5layer formation in cerebral cortex (GO:0021819)4.50257134
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50010034
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.48707211
8glutamate secretion (GO:0014047)4.34727059
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.30802515
10proline transport (GO:0015824)4.19965516
11NIK/NF-kappaB signaling (GO:0038061)4.14241851
12vocalization behavior (GO:0071625)4.13456004
13sodium ion export (GO:0071436)4.12443381
14activation of MAPKKK activity (GO:0000185)4.07773895
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.97672851
16myeloid dendritic cell differentiation (GO:0043011)3.96055447
17synaptic vesicle exocytosis (GO:0016079)3.90007074
18regulation of synaptic vesicle exocytosis (GO:2000300)3.86892058
19B cell receptor signaling pathway (GO:0050853)3.79541272
20regulation of synapse structural plasticity (GO:0051823)3.73720371
21cellular potassium ion homeostasis (GO:0030007)3.67893633
22B cell homeostasis (GO:0001782)3.64699235
23positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.57470594
24regulation of glutamate receptor signaling pathway (GO:1900449)3.56991745
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.54455486
26exploration behavior (GO:0035640)3.54416089
27positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.53063746
28positive regulation of synapse maturation (GO:0090129)3.51689347
29Golgi transport vesicle coating (GO:0048200)3.50033463
30COPI coating of Golgi vesicle (GO:0048205)3.50033463
31T cell lineage commitment (GO:0002360)3.47670314
32regulation of interferon-gamma biosynthetic process (GO:0045072)3.45553836
33regulation of B cell receptor signaling pathway (GO:0050855)3.43602976
34activation of protein kinase A activity (GO:0034199)3.41719176
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41210538
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41210538
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.41210538
38modulation by symbiont of host immune response (GO:0052553)3.41210538
39positive regulation by symbiont of host defense response (GO:0052509)3.41210538
40modulation by symbiont of host defense response (GO:0052031)3.41210538
41negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.40176806
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40114123
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.37434162
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36874559
45neurotransmitter secretion (GO:0007269)3.35875534
46regulation of synaptic vesicle transport (GO:1902803)3.35293126
47T-helper 1 type immune response (GO:0042088)3.34636159
48regulation of neuronal synaptic plasticity (GO:0048168)3.33899921
49regulation of early endosome to late endosome transport (GO:2000641)3.31681478
50cytoskeletal anchoring at plasma membrane (GO:0007016)3.29982710
51myeloid dendritic cell activation (GO:0001773)3.28629431
52response to muramyl dipeptide (GO:0032495)3.27396944
53skin morphogenesis (GO:0043589)3.26051083
54dendritic spine morphogenesis (GO:0060997)3.25907251
55interferon-gamma-mediated signaling pathway (GO:0060333)3.21693307
56cell communication by electrical coupling (GO:0010644)3.16543832
57protein localization to synapse (GO:0035418)3.16231485
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.15842468
59cellular response to type I interferon (GO:0071357)3.15678651
60type I interferon signaling pathway (GO:0060337)3.15678651
61negative regulation of potassium ion transmembrane transport (GO:1901380)3.15539461
62response to type I interferon (GO:0034340)3.12645913
63neuromuscular process controlling balance (GO:0050885)3.10321541
64establishment of nucleus localization (GO:0040023)3.10088191
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.10058732
66cerebellar granule cell differentiation (GO:0021707)3.09735077
67adhesion of symbiont to host (GO:0044406)3.08421681
68regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.08320184
69antigen processing and presentation of endogenous antigen (GO:0019883)3.08096713
70gonadal mesoderm development (GO:0007506)3.06164425
71regulation of dendritic spine morphogenesis (GO:0061001)3.06114536
72synaptic transmission, glutamatergic (GO:0035249)3.04210938
73cell-substrate adherens junction assembly (GO:0007045)3.03761674
74focal adhesion assembly (GO:0048041)3.03761674
75B cell proliferation (GO:0042100)3.03298971
76neuronal action potential propagation (GO:0019227)3.02894956
77regulation of ARF protein signal transduction (GO:0032012)3.00706274
78cell-substrate junction assembly (GO:0007044)2.95651578
79nerve growth factor signaling pathway (GO:0038180)2.92638422
80cortical actin cytoskeleton organization (GO:0030866)2.91822625
81auditory behavior (GO:0031223)2.90067503
82positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.89884612
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89675167
84long-term memory (GO:0007616)2.88862562
85maintenance of protein location in nucleus (GO:0051457)2.86122738
86modulation by symbiont of host cellular process (GO:0044068)2.85870844
87dendritic cell differentiation (GO:0097028)2.85621504
88pinocytosis (GO:0006907)2.85534242
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.84689651
90adherens junction assembly (GO:0034333)2.83111602
91immunoglobulin mediated immune response (GO:0016064)2.82784081
92activation of Rac GTPase activity (GO:0032863)2.82395006
93serine transport (GO:0032329)2.82327107
94potassium ion import (GO:0010107)2.81598093
95cellular response to arsenic-containing substance (GO:0071243)2.80647942
96regulation of apoptotic process involved in morphogenesis (GO:1902337)2.79362138
97neurotransmitter-gated ion channel clustering (GO:0072578)2.78950227
98dendrite morphogenesis (GO:0048813)2.78888700
99membrane raft organization (GO:0031579)2.78735508
100cell adhesion mediated by integrin (GO:0033627)2.78511650
101barbed-end actin filament capping (GO:0051016)2.78382765
102T cell costimulation (GO:0031295)2.78025767
103regulation of excitatory postsynaptic membrane potential (GO:0060079)2.77266836
104adhesion of symbiont to host cell (GO:0044650)2.76721443
105virion attachment to host cell (GO:0019062)2.76721443
106positive regulation of Rap GTPase activity (GO:0032854)2.76223787
107negative regulation of erythrocyte differentiation (GO:0045647)2.75870874
108regulation of type I interferon-mediated signaling pathway (GO:0060338)2.75120923
109hypotonic response (GO:0006971)2.74513381
110regulation of protein heterodimerization activity (GO:0043497)2.74270927
111regulation of ARF GTPase activity (GO:0032312)2.74055527
112negative thymic T cell selection (GO:0045060)2.73230213
113lymphocyte costimulation (GO:0031294)2.73046034
114regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72154511
115regulation of Rap GTPase activity (GO:0032317)2.71142823
116T cell migration (GO:0072678)2.70980110
117gamma-aminobutyric acid transport (GO:0015812)2.70137421
118glutamate receptor signaling pathway (GO:0007215)2.67633376
119neuron-neuron synaptic transmission (GO:0007270)2.67487107
120negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66705825
121positive regulation of humoral immune response (GO:0002922)2.66597980
122regulation of synaptic plasticity (GO:0048167)2.66240891
123mannose metabolic process (GO:0006013)2.66173970
124cerebellar Purkinje cell differentiation (GO:0021702)2.65130189
125positive regulation of membrane potential (GO:0045838)2.64666575
126thymic T cell selection (GO:0045061)2.64001008
127endodermal cell differentiation (GO:0035987)2.63873891
128positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.62278912
129positive regulation of fibroblast migration (GO:0010763)2.61915940
130regulation of interleukin-2 biosynthetic process (GO:0045076)2.61597476
131G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.61244261
132positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.61022361
133regulation of postsynaptic membrane potential (GO:0060078)2.60889723
134neurotransmitter transport (GO:0006836)2.60401897
135bone resorption (GO:0045453)2.60349647
136signal complex assembly (GO:0007172)2.59828273
137cell migration in hindbrain (GO:0021535)2.58754294
138positive regulation of protein oligomerization (GO:0032461)2.58529500
139positive regulation of protein dephosphorylation (GO:0035307)2.58128539
140regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56732382
141cortical cytoskeleton organization (GO:0030865)2.56730767
142germinal center formation (GO:0002467)2.55655874
143retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.55469267
144positive regulation of gamma-delta T cell activation (GO:0046645)2.55120874
145glycine transport (GO:0015816)2.54205748
146negative regulation of toll-like receptor signaling pathway (GO:0034122)2.54134422
147negative regulation of bone remodeling (GO:0046851)2.53970865
148negative regulation of osteoblast proliferation (GO:0033689)2.53916191
149regulation of interferon-beta biosynthetic process (GO:0045357)2.53526912
150regulation of dendritic spine development (GO:0060998)2.53093607
151regulation of clathrin-mediated endocytosis (GO:2000369)2.52880687
152regulation of voltage-gated calcium channel activity (GO:1901385)2.49903412
153histone H4-K8 acetylation (GO:0043982)2.49900902
154histone H4-K5 acetylation (GO:0043981)2.49900902
155ovulation cycle (GO:0042698)2.49437677
156lymphocyte homeostasis (GO:0002260)2.49305301
157negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.48583384
158prepulse inhibition (GO:0060134)2.48569432
159negative regulation of anoikis (GO:2000811)2.48327793
160regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.48283394
161cell communication involved in cardiac conduction (GO:0086065)2.47983369
162synaptic vesicle endocytosis (GO:0048488)2.46362087
163detection of temperature stimulus (GO:0016048)2.46298488
164cellular response to interferon-gamma (GO:0071346)2.45833525
165positive thymic T cell selection (GO:0045059)2.44851233
166mitochondrion distribution (GO:0048311)2.44753694
167response to auditory stimulus (GO:0010996)2.44526114
168chondrocyte proliferation (GO:0035988)2.43380425
169regulation of neurotransmitter secretion (GO:0046928)2.43307090
170cAMP biosynthetic process (GO:0006171)2.42211707
171regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.42198348
172regulation of synapse maturation (GO:0090128)2.42105175
173platelet aggregation (GO:0070527)2.39644693
174intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.39429026
175dendritic spine organization (GO:0097061)2.39265511
176positive regulation of endothelial cell apoptotic process (GO:2000353)2.39015475
177positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.38790391
178positive regulation of dendritic spine development (GO:0060999)2.38788766
179endocytic recycling (GO:0032456)2.37821860
180regulation of vitamin D biosynthetic process (GO:0060556)2.36884553
181regulation of T-helper 1 cell differentiation (GO:0045625)2.36876812
182response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.36484647
183response to host defenses (GO:0052200)2.36484647
184potassium ion homeostasis (GO:0055075)2.36374306
185cellular sodium ion homeostasis (GO:0006883)2.35670994
186long term synaptic depression (GO:0060292)2.35417334
187regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.34590160
188plasma membrane repair (GO:0001778)2.34444731
189calcium-mediated signaling using intracellular calcium source (GO:0035584)2.33957416
190protein targeting to Golgi (GO:0000042)2.33924422
191vesicle transport along microtubule (GO:0047496)2.33836865
192stress fiber assembly (GO:0043149)2.33364542
193membrane repolarization (GO:0086009)2.33308590
194protein localization to endosome (GO:0036010)2.31412405
195regulation of neurotransmitter levels (GO:0001505)2.30080685
196chemosensory behavior (GO:0007635)2.29940288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.84770101
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.23357647
3EZH2_22144423_ChIP-Seq_EOC_Human3.22148094
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.86283570
5VDR_21846776_ChIP-Seq_THP-1_Human2.83536376
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.67141342
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.47352335
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34752136
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34752136
10KDM2B_26808549_Chip-Seq_K562_Human2.32883537
11* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29673833
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29319963
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29067262
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28178930
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26422224
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21775864
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.20713340
18ZFP281_18757296_ChIP-ChIP_E14_Mouse2.17903423
19DROSHA_22980978_ChIP-Seq_HELA_Human2.17204992
20* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15204134
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14635792
22MAF_26560356_Chip-Seq_TH1_Human2.14351889
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.13085673
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.09507046
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07153553
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04119964
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01177462
28ZFP281_27345836_Chip-Seq_ESCs_Mouse1.94371341
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91072186
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90488498
31VDR_24763502_ChIP-Seq_THP-1_Human1.90353514
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89694248
33* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88457261
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.86845762
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.86845762
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.86845762
37* RNF2_27304074_Chip-Seq_ESCs_Mouse1.85428895
38REST_21632747_ChIP-Seq_MESCs_Mouse1.82558558
39* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81727153
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80879395
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80644754
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79823497
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79127289
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.78177502
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78023921
46KDM2B_26808549_Chip-Seq_DND41_Human1.77387757
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.76351464
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73969357
49* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73176018
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.72388669
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72149386
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71066139
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70955791
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70349791
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67143351
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65152109
57* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65136281
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.64588203
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63395853
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63254796
61* REST_18959480_ChIP-ChIP_MESCs_Mouse1.61210396
62* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60461585
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58210361
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54859399
65CLOCK_20551151_ChIP-Seq_293T_Human1.54724514
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53602988
67LXR_22292898_ChIP-Seq_THP-1_Human1.50679586
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.50642818
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49731635
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46067384
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46029801
72MAF_26560356_Chip-Seq_TH2_Human1.44931822
73UTX_26944678_Chip-Seq_JUKART_Human1.42750508
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42551095
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.42248112
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.42126101
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42069124
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.41508425
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41015892
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40769561
81* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40489114
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.40300539
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.39764820
84* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39682600
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38061139
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37186980
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36694310
88* TCF7_22412390_ChIP-Seq_EML_Mouse1.36496092
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35605776
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.35587803
91* UBF1/2_26484160_Chip-Seq_HMECs_Human1.35090241
92GATA1_19941826_ChIP-Seq_K562_Human1.30973038
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30735272
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.29244111
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29147688
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29112257
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27589305
98SMC4_20622854_ChIP-Seq_HELA_Human1.26102338
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26000662
100MYB_26560356_Chip-Seq_TH1_Human1.24624102
101TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.23527220
102* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23342989
103* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23132079
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22434054
105ATF3_27146783_Chip-Seq_COLON_Human1.21339788
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19282836
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18698312
108* IRF8_27001747_Chip-Seq_BMDM_Mouse1.17787943
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16365396
110* NCOR1_26117541_ChIP-Seq_K562_Human1.16073457
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16049618
112IRF8_21731497_ChIP-ChIP_J774_Mouse1.15879029
113TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15314538
114* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14474444
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13809299
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13338515
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13206239
118EED_16625203_ChIP-ChIP_MESCs_Mouse1.12308301
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11375033
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10469454
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09528050
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09213270
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09030305
124CREB1_26743006_Chip-Seq_LNCaP_Human1.09022268
125SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08376957
126ELK3_25401928_ChIP-Seq_HUVEC_Human1.08289876
127* SMAD3_21741376_ChIP-Seq_HESCs_Human1.07577286
128MYB_26560356_Chip-Seq_TH2_Human1.07035930
129RACK7_27058665_Chip-Seq_MCF-7_Human1.06875345
130P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06646826
131GATA1_19941827_ChIP-Seq_MEL_Mouse1.05877430
132AHR_22903824_ChIP-Seq_MCF-7_Human1.05049245
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04774319
134AR_19668381_ChIP-Seq_PC3_Human1.04517161
135CIITA_25753668_ChIP-Seq_RAJI_Human1.04054835
136* TET1_21490601_ChIP-Seq_MESCs_Mouse1.03745968
137MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03738816
138TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03017309
139ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02414285
140NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02365269
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02316686
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01456281
143ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00764405
144ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00395696
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99207170
146ZNF263_19887448_ChIP-Seq_K562_Human0.98182795
147SMAD_19615063_ChIP-ChIP_OVARY_Human0.98035890
148NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97899090
149RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97668542
150FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97538960
151OCT4_19829295_ChIP-Seq_ESCs_Human0.97207681
152SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96180856
153SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96180856
154CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95654806
155RUNX1_27514584_Chip-Seq_MCF-7_Human0.95088807
156SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94841977
157CDX2_20551321_ChIP-Seq_CACO-2_Human0.93450742
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.91872540
159GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91465116
160MYC_22102868_ChIP-Seq_BL_Human0.91260050
161NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91031796
162PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90983479
163ESR1_20079471_ChIP-ChIP_T-47D_Human0.90901842
164CTCF_27219007_Chip-Seq_Bcells_Human0.90895592
165CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90003345
166CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89725393
167* SMAD4_21741376_ChIP-Seq_HESCs_Human0.88990809
168ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88269931
169TP53_22127205_ChIP-Seq_IMR90_Human0.86461851
170FOXO3_23340844_ChIP-Seq_DLD1_Human0.85675617
171TP53_20018659_ChIP-ChIP_R1E_Mouse0.85289689
172* SOX2_21211035_ChIP-Seq_LN229_Gbm0.85177690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.44203576
2MP0008438_abnormal_cutaneous_collagen4.75518021
3MP0000685_abnormal_immune_system3.54322847
4MP0004858_abnormal_nervous_system3.51480428
5MP0003635_abnormal_synaptic_transmissio3.50666359
6MP0004270_analgesia3.28840810
7MP0002063_abnormal_learning/memory/cond2.75422133
8MP0003566_abnormal_cell_adhesion2.74311152
9MP0009046_muscle_twitch2.58840304
10MP0005387_immune_system_phenotype2.58536639
11MP0001790_abnormal_immune_system2.58536639
12MP0005671_abnormal_response_to2.46936635
13MP0008961_abnormal_basal_metabolism2.44888563
14MP0003880_abnormal_central_pattern2.42661918
15MP0009745_abnormal_behavioral_response2.41418487
16MP0003279_aneurysm2.39238480
17MP0002064_seizures2.38266373
18MP0003436_decreased_susceptibility_to2.33562911
19MP0005000_abnormal_immune_tolerance2.29265063
20MP0002572_abnormal_emotion/affect_behav2.20535831
21MP0005623_abnormal_meninges_morphology2.14881655
22MP0001835_abnormal_antigen_presentation2.14586128
23MP0002877_abnormal_melanocyte_morpholog2.13620346
24MP0001958_emphysema2.09928278
25MP0001800_abnormal_humoral_immune2.09816367
26MP0001486_abnormal_startle_reflex2.09096561
27MP0002909_abnormal_adrenal_gland2.08822280
28MP0005423_abnormal_somatic_nervous2.02477064
29MP0002254_reproductive_system_inflammat2.01859458
30MP0005167_abnormal_blood-brain_barrier1.98372523
31MP0002734_abnormal_mechanical_nocicepti1.93571122
32MP0003705_abnormal_hypodermis_morpholog1.91554972
33MP0008569_lethality_at_weaning1.90297804
34MP0005451_abnormal_body_composition1.90025810
35MP0004510_myositis1.89678437
36MP0005257_abnormal_intraocular_pressure1.89550377
37MP0002272_abnormal_nervous_system1.86923819
38MP0001348_abnormal_lacrimal_gland1.84328521
39MP0003329_amyloid_beta_deposits1.81543216
40MP0002822_catalepsy1.80988591
41MP0001440_abnormal_grooming_behavior1.78886322
42MP0002452_abnormal_antigen_presenting1.77788941
43MP0003763_abnormal_thymus_physiology1.75143746
44MP0009780_abnormal_chondrocyte_physiolo1.74315493
45MP0004947_skin_inflammation1.72991025
46MP0001501_abnormal_sleep_pattern1.68058977
47MP0002723_abnormal_immune_serum1.66342928
48MP0005499_abnormal_olfactory_system1.64480066
49MP0005394_taste/olfaction_phenotype1.64480066
50MP0004811_abnormal_neuron_physiology1.61056698
51MP0004084_abnormal_cardiac_muscle1.58839384
52MP0002398_abnormal_bone_marrow1.57379434
53MP0004885_abnormal_endolymph1.56967759
54MP0002733_abnormal_thermal_nociception1.55535436
55MP0002420_abnormal_adaptive_immunity1.55319428
56MP0003045_fibrosis1.54185480
57MP0000751_myopathy1.52653225
58MP0001968_abnormal_touch/_nociception1.52431999
59MP0001819_abnormal_immune_cell1.52047076
60MP0002184_abnormal_innervation1.48863008
61MP0002166_altered_tumor_susceptibility1.48402776
62MP0005275_abnormal_skin_tensile1.46656582
63MP0000767_abnormal_smooth_muscle1.44700175
64MP0009840_abnormal_foam_cell1.43331761
65MP0000858_altered_metastatic_potential1.42080848
66MP0000955_abnormal_spinal_cord1.41294905
67MP0001970_abnormal_pain_threshold1.40226964
68MP0000778_abnormal_nervous_system1.37987983
69MP0000003_abnormal_adipose_tissue1.37813243
70MP0002998_abnormal_bone_remodeling1.36163191
71MP0001542_abnormal_bone_strength1.35792060
72MP0003283_abnormal_digestive_organ1.35200670
73MP0005025_abnormal_response_to1.34926766
74MP0000716_abnormal_immune_system1.34000994
75MP0003303_peritoneal_inflammation1.32998135
76MP0005023_abnormal_wound_healing1.32749595
77MP0003879_abnormal_hair_cell1.30856183
78MP0003656_abnormal_erythrocyte_physiolo1.30002875
79MP0002067_abnormal_sensory_capabilities1.28219854
80MP0003950_abnormal_plasma_membrane1.28144422
81MP0005464_abnormal_platelet_physiology1.27727675
82MP0003787_abnormal_imprinting1.26111640
83MP0002419_abnormal_innate_immunity1.24900040
84MP0008260_abnormal_autophagy1.24278966
85MP0009384_cardiac_valve_regurgitation1.22725649
86MP0002429_abnormal_blood_cell1.21642469
87MP0009333_abnormal_splenocyte_physiolog1.20608138
88MP0002089_abnormal_postnatal_growth/wei1.20469025
89MP0003300_gastrointestinal_ulcer1.20195351
90MP0004808_abnormal_hematopoietic_stem1.20063875
91MP0002006_tumorigenesis1.19178522
92MP0002138_abnormal_hepatobiliary_system1.19001505
93MP0004085_abnormal_heartbeat1.16924554
94MP0003633_abnormal_nervous_system1.16301135
95MP0003137_abnormal_impulse_conducting1.15512484
96MP0003075_altered_response_to1.12330945
97MP0003091_abnormal_cell_migration1.11986519
98MP0005621_abnormal_cell_physiology1.11896481
99MP0002557_abnormal_social/conspecific_i1.10981607
100MP0002148_abnormal_hypersensitivity_rea1.10211646
101MP0003122_maternal_imprinting1.10057440
102MP0002332_abnormal_exercise_endurance1.09949386
103MP0009785_altered_susceptibility_to1.09857851
104MP0004215_abnormal_myocardial_fiber1.09647846
105MP0010234_abnormal_vibrissa_follicle1.09045073
106MP0004924_abnormal_behavior1.08808471
107MP0005386_behavior/neurological_phenoty1.08808471
108* MP0002882_abnormal_neuron_morphology1.08382148
109MP0004145_abnormal_muscle_electrophysio1.08025274
110MP0002066_abnormal_motor_capabilities/c1.06458972
111MP0002722_abnormal_immune_system1.05717816
112MP0003172_abnormal_lysosome_physiology1.02677348
113MP0005076_abnormal_cell_differentiation1.02674675
114MP0000689_abnormal_spleen_morphology1.02644333
115MP0004264_abnormal_extraembryonic_tissu1.01260925
116MP0002405_respiratory_system_inflammati1.00971895
117MP0005310_abnormal_salivary_gland1.00530715
118MP0001533_abnormal_skeleton_physiology0.99091313
119MP0003453_abnormal_keratinocyte_physiol0.97749530
120MP0002735_abnormal_chemical_nociception0.97575893
121MP0003191_abnormal_cellular_cholesterol0.97460763
122MP0001845_abnormal_inflammatory_respons0.97292526
123MP0000733_abnormal_muscle_development0.97176219
124MP0008874_decreased_physiological_sensi0.96243966
125MP0003890_abnormal_embryonic-extraembry0.96009445
126MP0005645_abnormal_hypothalamus_physiol0.95983449
127MP0002060_abnormal_skin_morphology0.95250446
128MP0010352_gastrointestinal_tract_polyps0.94980408
129MP0010368_abnormal_lymphatic_system0.94493558
130MP0008872_abnormal_physiological_respon0.94055495
131MP0003183_abnormal_peptide_metabolism0.93661199
132MP0003448_altered_tumor_morphology0.92722952
133MP0000604_amyloidosis0.92445494
134MP0004484_altered_response_of0.91715390
135MP0004087_abnormal_muscle_fiber0.91207626
136MP0003631_nervous_system_phenotype0.90581461
137MP0001853_heart_inflammation0.90453022
138MP0005058_abnormal_lysosome_morphology0.87063793
139MP0010155_abnormal_intestine_physiology0.86126954
140MP0000343_altered_response_to0.85837963
141MP0004036_abnormal_muscle_relaxation0.85761036
142MP0003632_abnormal_nervous_system0.84664797
143* MP0002152_abnormal_brain_morphology0.84509054
144MP0003634_abnormal_glial_cell0.83527861
145MP0002736_abnormal_nociception_after0.83496807
146MP0006138_congestive_heart_failure0.83279118
147MP0002653_abnormal_ependyma_morphology0.81002201
148MP0001849_ear_inflammation0.80882979
149MP0002933_joint_inflammation0.80875055
150MP0005390_skeleton_phenotype0.80787892
151MP0005503_abnormal_tendon_morphology0.79375226
152MP0002896_abnormal_bone_mineralization0.78815333
153MP0000703_abnormal_thymus_morphology0.78171995
154MP0003795_abnormal_bone_structure0.77732491
155MP0004272_abnormal_basement_membrane0.76807093
156MP0000569_abnormal_digit_pigmentation0.76113495
157MP0004043_abnormal_pH_regulation0.76040626
158MP0002163_abnormal_gland_morphology0.75407854
159MP0005165_increased_susceptibility_to0.74503486
160MP0000350_abnormal_cell_proliferation0.73898833
161MP0005384_cellular_phenotype0.72101077
162MP0003690_abnormal_glial_cell0.71340728
163MP0008770_decreased_survivor_rate0.70930538
164MP0000490_abnormal_crypts_of0.70753942
165MP0002127_abnormal_cardiovascular_syste0.70655786
166MP0005508_abnormal_skeleton_morphology0.70613987
167MP0000920_abnormal_myelination0.68297106
168MP0002925_abnormal_cardiovascular_devel0.65687871
169MP0005620_abnormal_muscle_contractility0.64900235
170MP0000759_abnormal_skeletal_muscle0.64079783
171MP0002972_abnormal_cardiac_muscle0.63254233
172MP0002090_abnormal_vision0.62884772
173MP0000749_muscle_degeneration0.61355717
174MP0003119_abnormal_digestive_system0.59819385
175MP0000013_abnormal_adipose_tissue0.59575724
176MP0000750_abnormal_muscle_regeneration0.59260991
177MP0002269_muscular_atrophy0.58870748
178MP0005330_cardiomyopathy0.58405148

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)5.12629941
2Gastrointestinal stroma tumor (HP:0100723)5.11122955
3Premature rupture of membranes (HP:0001788)4.89125985
4Myokymia (HP:0002411)4.64518911
5Protrusio acetabuli (HP:0003179)4.50743738
6Emphysema (HP:0002097)3.85185019
7Focal seizures (HP:0007359)3.82226021
8IgA deficiency (HP:0002720)3.73422708
9Focal motor seizures (HP:0011153)3.54827282
10Visual hallucinations (HP:0002367)3.48820040
11Cellulitis (HP:0100658)3.35611566
12Action tremor (HP:0002345)3.33609911
13Amyotrophic lateral sclerosis (HP:0007354)3.32430770
14Agammaglobulinemia (HP:0004432)3.30123745
15Bilateral microphthalmos (HP:0007633)3.24314117
16Epileptic encephalopathy (HP:0200134)3.20988623
17Ankle contracture (HP:0006466)3.20138912
18Hepatoblastoma (HP:0002884)3.13413376
19Difficulty running (HP:0009046)3.11719697
20Distal upper limb amyotrophy (HP:0007149)3.06328222
21Upper limb amyotrophy (HP:0009129)3.06328222
22Ankle clonus (HP:0011448)3.03615743
23Atonic seizures (HP:0010819)2.96647647
24Hand muscle atrophy (HP:0009130)2.92392462
25Recurrent sinusitis (HP:0011108)2.92362393
26Supranuclear gaze palsy (HP:0000605)2.90881920
27Amblyopia (HP:0000646)2.83823298
28Febrile seizures (HP:0002373)2.82333316
29Bladder diverticulum (HP:0000015)2.81705928
30Annular pancreas (HP:0001734)2.75879810
31Neoplasm of the heart (HP:0100544)2.74202401
32Slender build (HP:0001533)2.73626145
33Hemiparesis (HP:0001269)2.66632032
34Hemiplegia (HP:0002301)2.63719809
35Lymphopenia (HP:0001888)2.62932054
36Vertebral compression fractures (HP:0002953)2.62761415
37Resting tremor (HP:0002322)2.61406261
38Spinal rigidity (HP:0003306)2.59788761
39Dilatation of the ascending aorta (HP:0005111)2.59569458
40Abnormality of cells of the lymphoid lineage (HP:0012140)2.58509096
41Distal lower limb amyotrophy (HP:0008944)2.57467984
42Achilles tendon contracture (HP:0001771)2.56551811
43Recurrent lower respiratory tract infections (HP:0002783)2.53728684
44Progressive cerebellar ataxia (HP:0002073)2.52460310
45Depression (HP:0000716)2.51000749
46Aortic dissection (HP:0002647)2.47943898
47Generalized tonic-clonic seizures (HP:0002069)2.45019913
48Wormian bones (HP:0002645)2.43934257
49Genu recurvatum (HP:0002816)2.43840981
50Dysmetric saccades (HP:0000641)2.43317882
51Dysdiadochokinesis (HP:0002075)2.42941526
52Macroorchidism (HP:0000053)2.40470015
53Aortic aneurysm (HP:0004942)2.39979538
54Ventricular fibrillation (HP:0001663)2.39758039
55Poor eye contact (HP:0000817)2.39171088
56Recurrent viral infections (HP:0004429)2.38273108
57Dialeptic seizures (HP:0011146)2.37357166
58Upper limb muscle weakness (HP:0003484)2.34873391
59Restrictive lung disease (HP:0002091)2.34438922
60Follicular hyperkeratosis (HP:0007502)2.34394882
61Long palpebral fissure (HP:0000637)2.33378553
62Abnormality of the corticospinal tract (HP:0002492)2.33144415
63Horizontal nystagmus (HP:0000666)2.32866798
64Absence seizures (HP:0002121)2.32165512
65Vasculitis (HP:0002633)2.31511238
66Abnormal social behavior (HP:0012433)2.30426914
67Impaired social interactions (HP:0000735)2.30426914
68Generalized hypotonia (HP:0001290)2.29972000
69Atrophic scars (HP:0001075)2.29827575
70Tetraplegia (HP:0002445)2.29590607
71Intention tremor (HP:0002080)2.28248209
72Vascular tortuosity (HP:0004948)2.28023988
73Abnormality of the astrocytes (HP:0100707)2.27194243
74Astrocytoma (HP:0009592)2.27194243
75Insomnia (HP:0100785)2.25418843
76Increased variability in muscle fiber diameter (HP:0003557)2.25341361
77Type 1 muscle fiber predominance (HP:0003803)2.25183861
78Hyperventilation (HP:0002883)2.24295468
79Renal duplication (HP:0000075)2.23750126
80Bundle branch block (HP:0011710)2.22689274
81Pointed chin (HP:0000307)2.22236731
82Bowel diverticulosis (HP:0005222)2.21760317
83Apathy (HP:0000741)2.21065730
84Spondylolisthesis (HP:0003302)2.20171786
85Hyperacusis (HP:0010780)2.19938898
86Abnormality of the Achilles tendon (HP:0005109)2.18325832
87Recurrent bronchitis (HP:0002837)2.18199235
88Arterial tortuosity (HP:0005116)2.17973856
89Dysmetria (HP:0001310)2.16735110
90Hypertensive crisis (HP:0100735)2.16670998
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.16543840
92Meningitis (HP:0001287)2.16460921
93Cholecystitis (HP:0001082)2.14674734
94Abnormal gallbladder physiology (HP:0012438)2.14674734
95Fragile skin (HP:0001030)2.13767658
96Lower limb amyotrophy (HP:0007210)2.13239236
97Urinary urgency (HP:0000012)2.12237715
98Entropion (HP:0000621)2.11079018
99Ependymoma (HP:0002888)2.10400238
100Elbow flexion contracture (HP:0002987)2.09110553
101Mediastinal lymphadenopathy (HP:0100721)2.09090537
102Urinary bladder sphincter dysfunction (HP:0002839)2.08153294
103Rapidly progressive (HP:0003678)2.06922039
104Papilledema (HP:0001085)2.06811863
105Mitral regurgitation (HP:0001653)2.06362049
106Intellectual disability, profound (HP:0002187)2.06103061
107Peripheral hypomyelination (HP:0007182)2.03404724
108Abnormality of ocular smooth pursuit (HP:0000617)2.02832605
109Blue sclerae (HP:0000592)2.01942334
110Colitis (HP:0002583)2.01102293
111Broad-based gait (HP:0002136)2.00026016
112Ankyloglossia (HP:0010296)1.99846105
113Neonatal short-limb short stature (HP:0008921)1.99680733
114Flat cornea (HP:0007720)1.99171692
115Gaze-evoked nystagmus (HP:0000640)1.98892835
116Disproportionate tall stature (HP:0001519)1.98490009
117Mild short stature (HP:0003502)1.98196517
118Osteolytic defects of the hand bones (HP:0009699)1.98101726
119Osteolytic defects of the phalanges of the hand (HP:0009771)1.98101726
120Impaired vibration sensation in the lower limbs (HP:0002166)1.97373718
121Camptodactyly of toe (HP:0001836)1.97351219
122Postural instability (HP:0002172)1.96949890
123Flexion contracture of toe (HP:0005830)1.96688818
124Joint contractures involving the joints of the feet (HP:0100492)1.96688818
125Fatigue (HP:0012378)1.96465496
126Ulnar bowing (HP:0003031)1.95658866
127Impaired smooth pursuit (HP:0007772)1.95591975
128Genetic anticipation (HP:0003743)1.95538839
129Spastic gait (HP:0002064)1.93712803
130Elfin facies (HP:0004428)1.91762858
131Diminished motivation (HP:0000745)1.91635110
132Mutism (HP:0002300)1.91358727
133Papilloma (HP:0012740)1.91343494
134Verrucae (HP:0200043)1.91343494
135Small epiphyses (HP:0010585)1.90580677
136Spastic tetraparesis (HP:0001285)1.90363610
137Lower limb muscle weakness (HP:0007340)1.89847873
138Acrocyanosis (HP:0001063)1.89809842
139Overriding aorta (HP:0002623)1.87313274
140Neuronal loss in central nervous system (HP:0002529)1.87143969
141Hypochromic microcytic anemia (HP:0004840)1.86507569
142Lymphangioma (HP:0100764)1.86326140
143Abnormality of skeletal muscle fiber size (HP:0012084)1.85646117
144Abnormality of binocular vision (HP:0011514)1.85309290
145Diplopia (HP:0000651)1.85309290
146Obstructive sleep apnea (HP:0002870)1.84934055
147Generalized amyotrophy (HP:0003700)1.84772932
148Abnormality of the musculature of the hand (HP:0001421)1.82672547
149Increased connective tissue (HP:0009025)1.82639858
150Soft skin (HP:0000977)1.82276181
151Recurrent pneumonia (HP:0006532)1.81871642
152Cerebral inclusion bodies (HP:0100314)1.81664548
153Osteomyelitis (HP:0002754)1.81225804
154IgM deficiency (HP:0002850)1.80151275
155Stereotypic behavior (HP:0000733)1.79428338
156Overgrowth (HP:0001548)1.79395724
157Onycholysis (HP:0001806)1.79341579
158Flattened epiphyses (HP:0003071)1.78745671
159Drooling (HP:0002307)1.78590856
160Excessive salivation (HP:0003781)1.78590856
161Mildly elevated creatine phosphokinase (HP:0008180)1.78359531
162Hypoventilation (HP:0002791)1.78132072
163Truncal ataxia (HP:0002078)1.77942097
164Abnormality of dentin (HP:0010299)1.77728091
165Persistence of primary teeth (HP:0006335)1.77331915
166Xerostomia (HP:0000217)1.77190557
167Myocardial infarction (HP:0001658)1.76691954
168Status epilepticus (HP:0002133)1.76160167
169Clonus (HP:0002169)1.75960944
170Natal tooth (HP:0000695)1.75541264
171Open mouth (HP:0000194)1.75466147
172Chronic diarrhea (HP:0002028)1.75386500
173Shallow orbits (HP:0000586)1.75240324
174Megalencephaly (HP:0001355)1.72489433
175Biconcave vertebral bodies (HP:0004586)1.71793488
176Cerebral aneurysm (HP:0004944)1.70792185
177Abnormal delayed hypersensitivity skin test (HP:0002963)1.70730587
178Termporal pattern (HP:0011008)1.70659112
179Insidious onset (HP:0003587)1.70659112
180Distal lower limb muscle weakness (HP:0009053)1.70594276
181Arthralgia (HP:0002829)1.70047833
182Multiple enchondromatosis (HP:0005701)1.69505386
183Thoracolumbar scoliosis (HP:0002944)1.68994252
184EMG: neuropathic changes (HP:0003445)1.68749424
185Sudden death (HP:0001699)1.68585475
186Torticollis (HP:0000473)1.67651728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.53210287
2MAP3K93.38788311
3TYRO33.18927655
4NEK93.16655322
5SMG12.98380254
6GRK52.88901780
7RIPK12.56657815
8PRKD32.54932701
9MAP3K142.52153951
10NTRK32.51817122
11MAP4K12.47466892
12EPHA42.43075511
13MARK12.39907745
14TAOK22.26761581
15PAK62.15676996
16TRIB32.12002093
17DAPK22.11758445
18NTRK12.04104108
19IRAK32.02600882
20WNK11.90001445
21KSR21.86507617
22MAP3K41.83102377
23ARAF1.81265681
24ERN11.77929354
25CAMKK11.69845350
26MINK11.66038226
27NME21.62662230
28MAP2K41.62449325
29TAOK11.57972737
30ALK1.57097018
31GRK61.53677945
32TBK11.52371237
33FGFR41.52143830
34EEF2K1.52069215
35NTRK21.51614809
36SIK21.47342215
37SIK11.43365288
38MARK21.41304648
39PIM21.35813118
40STK381.34796339
41DAPK31.33497161
42JAK11.31597025
43IRAK41.29589910
44LATS21.20921264
45MAP3K71.18770037
46PHKG11.17333451
47PHKG21.17333451
48CDK51.14111522
49PRKCH1.13603432
50LMTK21.11277378
51MAPK71.11034003
52CAMK41.09419752
53PDGFRA1.08867237
54TGFBR21.08181544
55IKBKE1.05509050
56MAP3K81.02463267
57RET1.01823897
58SYK0.97020290
59CHUK0.95190838
60ICK0.95096281
61STK110.93805435
62MAPK110.93784622
63BRAF0.93584437
64JAK30.92575001
65PAK30.89912368
66MATK0.88316350
67TYK20.87204624
68IKBKB0.86652847
69PAK20.86539715
70PRKG20.86529076
71KSR10.86314075
72TRPM70.86015448
73DMPK0.85239676
74CSF1R0.84898266
75FGFR30.84548527
76GRK10.84238349
77RIPK40.83233807
78SIK30.83220404
79BMX0.82867766
80BMPR20.81431635
81RPS6KA20.80763522
82PTK2B0.80517006
83MOS0.80450485
84MAP3K20.79100623
85PRPF4B0.78539493
86PKN20.77882705
87KIT0.77524242
88BLK0.76797240
89MAP3K110.75842153
90STK100.75701473
91PDK10.75683341
92DAPK10.75650271
93MAPK120.73099048
94MAP2K70.72481858
95CAMK10.70517021
96TIE10.69441139
97PRKCG0.68357210
98MAP2K30.66435884
99MAP3K100.65826857
100CDK150.64680030
101MAP3K130.64422901
102LIMK10.64265160
103TESK20.63892310
104TESK10.63318911
105EPHB10.63238273
106CDC42BPA0.63165619
107PTK20.61554986
108HIPK20.60369678
109CDK180.59682914
110MELK0.57533641
111PDPK10.57207081
112UHMK10.56099582
113FES0.56006424
114CDK140.55624663
115CDK11A0.54682622
116MAP3K10.54604934
117CDK40.54036544
118PTK60.53264064
119CAMK1G0.52862781
120BTK0.52681736
121CDK190.52527311
122EIF2AK30.52226257
123DDR20.50090522
124PAK40.49133435
125PAK10.46381520
126PRKCQ0.45927237
127SGK30.45603417
128GRK70.45136685
129DYRK1A0.44954066
130RPS6KA30.44782055
131ERBB40.44669392
132ADRBK20.44332655
133STK240.44046212
134FYN0.43439425
135CAMKK20.43134649
136PRKD20.43050281
137PDGFRB0.42974111
138PRKD10.42930154
139MAPK100.42492353
140PASK0.41535574
141MAP2K60.40964989
142MAPK40.40817210
143CCNB10.40171699
144AKT20.39581681
145SCYL20.38603415
146SGK10.38509844
147RPS6KC10.37450134
148RPS6KL10.37450134
149PIM10.36855678
150RAF10.36615657
151CDK90.36026796
152ROCK20.35875706
153CSK0.35550693
154MTOR0.34845013
155TTN0.33852532
156SRC0.33079468

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046722.90811392
2Allograft rejection_Homo sapiens_hsa053302.82107405
3Autoimmune thyroid disease_Homo sapiens_hsa053202.48035156
4Viral myocarditis_Homo sapiens_hsa054162.25485394
5Graft-versus-host disease_Homo sapiens_hsa053322.24254405
6Asthma_Homo sapiens_hsa053102.19072198
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16031961
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.13282689
9Long-term potentiation_Homo sapiens_hsa047202.11430475
10Primary immunodeficiency_Homo sapiens_hsa053402.11406883
11Glutamatergic synapse_Homo sapiens_hsa047242.01962430
12Systemic lupus erythematosus_Homo sapiens_hsa053221.97259017
13Olfactory transduction_Homo sapiens_hsa047401.95853825
14Circadian entrainment_Homo sapiens_hsa047131.94557318
15Type I diabetes mellitus_Homo sapiens_hsa049401.92624738
16Synaptic vesicle cycle_Homo sapiens_hsa047211.92437998
17Leishmaniasis_Homo sapiens_hsa051401.87630637
18Nicotine addiction_Homo sapiens_hsa050331.84495052
19GABAergic synapse_Homo sapiens_hsa047271.83141809
20Salivary secretion_Homo sapiens_hsa049701.79121897
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72755005
22Gastric acid secretion_Homo sapiens_hsa049711.72091381
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.64177410
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63979027
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63284832
26Morphine addiction_Homo sapiens_hsa050321.61511761
27Oxytocin signaling pathway_Homo sapiens_hsa049211.54967965
28Influenza A_Homo sapiens_hsa051641.53907320
29Dopaminergic synapse_Homo sapiens_hsa047281.52799317
30Toxoplasmosis_Homo sapiens_hsa051451.51934312
31Renin secretion_Homo sapiens_hsa049241.51731957
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50119116
33Amphetamine addiction_Homo sapiens_hsa050311.50049741
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48539903
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47595602
36Cholinergic synapse_Homo sapiens_hsa047251.47166350
37GnRH signaling pathway_Homo sapiens_hsa049121.46456054
38Long-term depression_Homo sapiens_hsa047301.38550814
39Bladder cancer_Homo sapiens_hsa052191.37178384
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36870517
41Apoptosis_Homo sapiens_hsa042101.36513535
42Measles_Homo sapiens_hsa051621.36182716
43Hepatitis B_Homo sapiens_hsa051611.35590490
44Viral carcinogenesis_Homo sapiens_hsa052031.35565472
45Dorso-ventral axis formation_Homo sapiens_hsa043201.34342433
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34087045
47Insulin secretion_Homo sapiens_hsa049111.33781795
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31626365
49Antigen processing and presentation_Homo sapiens_hsa046121.31122787
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30430724
51cAMP signaling pathway_Homo sapiens_hsa040241.29400931
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.27901201
53Herpes simplex infection_Homo sapiens_hsa051681.26382001
54mTOR signaling pathway_Homo sapiens_hsa041501.22849761
55Estrogen signaling pathway_Homo sapiens_hsa049151.22225657
56TNF signaling pathway_Homo sapiens_hsa046681.21614261
57Glioma_Homo sapiens_hsa052141.21236492
58Dilated cardiomyopathy_Homo sapiens_hsa054141.20781684
59Gap junction_Homo sapiens_hsa045401.20755116
60VEGF signaling pathway_Homo sapiens_hsa043701.20742549
61Small cell lung cancer_Homo sapiens_hsa052221.20659357
62Calcium signaling pathway_Homo sapiens_hsa040201.19312404
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18987473
64Epstein-Barr virus infection_Homo sapiens_hsa051691.17462840
65Shigellosis_Homo sapiens_hsa051311.17236480
66Taste transduction_Homo sapiens_hsa047421.16418600
67Osteoclast differentiation_Homo sapiens_hsa043801.12983453
68Alcoholism_Homo sapiens_hsa050341.12687778
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11737519
70Tuberculosis_Homo sapiens_hsa051521.09913156
71Type II diabetes mellitus_Homo sapiens_hsa049301.08767628
72ErbB signaling pathway_Homo sapiens_hsa040121.07719146
73HTLV-I infection_Homo sapiens_hsa051661.06924355
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06273864
75Neurotrophin signaling pathway_Homo sapiens_hsa047221.05372581
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04814947
77Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04758640
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04654368
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04444965
80Cocaine addiction_Homo sapiens_hsa050301.02807611
81* Axon guidance_Homo sapiens_hsa043601.02155913
82Vascular smooth muscle contraction_Homo sapiens_hsa042701.01336259
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99922460
84Choline metabolism in cancer_Homo sapiens_hsa052310.95061392
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94026925
86Rheumatoid arthritis_Homo sapiens_hsa053230.93965294
87Rap1 signaling pathway_Homo sapiens_hsa040150.93648251
88ECM-receptor interaction_Homo sapiens_hsa045120.93307171
89Serotonergic synapse_Homo sapiens_hsa047260.91991113
90Phagosome_Homo sapiens_hsa041450.91311714
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90352072
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90081935
93Hepatitis C_Homo sapiens_hsa051600.89389711
94MAPK signaling pathway_Homo sapiens_hsa040100.88880808
95Nitrogen metabolism_Homo sapiens_hsa009100.88701239
96Prion diseases_Homo sapiens_hsa050200.87983335
97Hematopoietic cell lineage_Homo sapiens_hsa046400.87807285
98Melanogenesis_Homo sapiens_hsa049160.82768031
99Other glycan degradation_Homo sapiens_hsa005110.82135696
100Non-small cell lung cancer_Homo sapiens_hsa052230.81822523
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81558617
102Inositol phosphate metabolism_Homo sapiens_hsa005620.80538058
103Endometrial cancer_Homo sapiens_hsa052130.79402234
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78875222
105Renal cell carcinoma_Homo sapiens_hsa052110.77948383
106p53 signaling pathway_Homo sapiens_hsa041150.77234911
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.76871742
108MicroRNAs in cancer_Homo sapiens_hsa052060.76546441
109Endocytosis_Homo sapiens_hsa041440.74584902
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.74479670
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74085873
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73980898
113Pancreatic secretion_Homo sapiens_hsa049720.73144765
114Ras signaling pathway_Homo sapiens_hsa040140.72946482
115Focal adhesion_Homo sapiens_hsa045100.72740403
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72477729
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72294456
118Ovarian steroidogenesis_Homo sapiens_hsa049130.72048531
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71508076
120Prostate cancer_Homo sapiens_hsa052150.71413546
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70780863
122Proteoglycans in cancer_Homo sapiens_hsa052050.70324662
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.70291332
124T cell receptor signaling pathway_Homo sapiens_hsa046600.70124517
125HIF-1 signaling pathway_Homo sapiens_hsa040660.69928656
126Malaria_Homo sapiens_hsa051440.69730150
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68807359
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68309738
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67515737
130Staphylococcus aureus infection_Homo sapiens_hsa051500.67424890
131Chemokine signaling pathway_Homo sapiens_hsa040620.66854022
132Prolactin signaling pathway_Homo sapiens_hsa049170.66122834
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.65064410
134Thyroid hormone synthesis_Homo sapiens_hsa049180.64695733
135B cell receptor signaling pathway_Homo sapiens_hsa046620.63611977
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63080097
137Pentose phosphate pathway_Homo sapiens_hsa000300.62144185
138Tight junction_Homo sapiens_hsa045300.61046505
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60326242
140Colorectal cancer_Homo sapiens_hsa052100.59969205
141Platelet activation_Homo sapiens_hsa046110.59288684
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58057003
143Oocyte meiosis_Homo sapiens_hsa041140.57787999
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56849077
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.56619521
146Chronic myeloid leukemia_Homo sapiens_hsa052200.56242690
147Bile secretion_Homo sapiens_hsa049760.56171368
148Salmonella infection_Homo sapiens_hsa051320.55240694
149Pancreatic cancer_Homo sapiens_hsa052120.54425842
150Vibrio cholerae infection_Homo sapiens_hsa051100.53707736
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52975912
152Amoebiasis_Homo sapiens_hsa051460.52872244
153Cardiac muscle contraction_Homo sapiens_hsa042600.51642048
154Acute myeloid leukemia_Homo sapiens_hsa052210.51515516
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50450440
156Thyroid cancer_Homo sapiens_hsa052160.50006788
157Wnt signaling pathway_Homo sapiens_hsa043100.49583820
158Insulin resistance_Homo sapiens_hsa049310.48249665
159African trypanosomiasis_Homo sapiens_hsa051430.47333855
160Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45075203

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