SEMG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)9.12895175
2regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033398.95201573
3prostanoid metabolic process (GO:0006692)8.76205112
4prostaglandin metabolic process (GO:0006693)8.76205112
5collecting duct development (GO:0072044)8.07892036
6mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)8.05047543
7nephron tubule formation (GO:0072079)8.03218290
8maintenance of gastrointestinal epithelium (GO:0030277)7.81013431
9mesonephros development (GO:0001823)7.78784146
10pattern specification involved in kidney development (GO:0061004)7.78681166
11negative regulation of metanephros development (GO:0072217)7.55407375
12metanephric nephron tubule development (GO:0072234)7.54414708
13metanephric tubule development (GO:0072170)7.54414708
14urogenital system development (GO:0001655)7.47733063
15metanephric nephron epithelium development (GO:0072243)6.85537350
16regulation of apoptotic process involved in morphogenesis (GO:1902337)6.64829196
17negative regulation of mesenchymal cell apoptotic process (GO:2001054)6.32613887
18metanephric epithelium development (GO:0072207)6.31646107
19epithelial structure maintenance (GO:0010669)6.15712725
20endocrine hormone secretion (GO:0060986)5.96291346
21fibroblast migration (GO:0010761)5.89602597
22regulation of hippo signaling (GO:0035330)5.68705452
23regulation of nephron tubule epithelial cell differentiation (GO:0072182)5.36944953
24cell differentiation involved in metanephros development (GO:0072202)5.23313279
25regulation of mesenchymal cell apoptotic process (GO:2001053)5.23072921
26nephron tubule development (GO:0072080)5.03146799
27positive regulation of metanephros development (GO:0072216)5.00880311
28specification of organ identity (GO:0010092)4.87850743
29regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.71193911
30regulation of stem cell maintenance (GO:2000036)4.69669285
31sodium-independent organic anion transport (GO:0043252)4.69598686
32mesenchymal cell differentiation involved in renal system development (GO:2001012)4.68649278
33mesenchymal cell differentiation involved in kidney development (GO:0072161)4.68649278
34metanephric mesenchyme development (GO:0072075)4.66167081
35negative regulation of kidney development (GO:0090185)4.48489019
36renal tubule development (GO:0061326)4.42030816
37positive regulation of glomerulus development (GO:0090193)4.40332854
38urinary tract smooth muscle contraction (GO:0014848)4.39235433
39cranial nerve morphogenesis (GO:0021602)4.27881326
40cranial nerve structural organization (GO:0021604)4.26550607
41mesenchymal to epithelial transition (GO:0060231)4.26532714
42anterior/posterior axis specification, embryo (GO:0008595)4.15745136
43positive regulation of digestive system process (GO:0060456)4.08257002
44kidney mesenchyme development (GO:0072074)4.02365469
45nephron epithelium development (GO:0072009)3.99128301
46regulation of fatty acid oxidation (GO:0046320)3.99030746
47ectodermal placode formation (GO:0060788)3.89207895
48positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.76264988
49tonic smooth muscle contraction (GO:0014820)3.73949968
50definitive hemopoiesis (GO:0060216)3.67387241
51fatty acid derivative transport (GO:1901571)3.67200310
52icosanoid transport (GO:0071715)3.67200310
53transcytosis (GO:0045056)3.63153017
54positive regulation of hormone metabolic process (GO:0032352)3.59720272
55hypotonic response (GO:0006971)3.57514897
56smooth muscle contraction (GO:0006939)3.57462102
57cardiovascular system development (GO:0072358)3.47809255
58muscle cell fate commitment (GO:0042693)3.40801500
59extracellular matrix assembly (GO:0085029)3.36911246
60thyroid gland development (GO:0030878)3.35438155
61regulation of metanephros development (GO:0072215)3.33802757
62polarized epithelial cell differentiation (GO:0030859)3.32067289
63endothelial cell chemotaxis (GO:0035767)3.32043698
64endocardial cushion morphogenesis (GO:0003203)3.29332052
65mammary gland development (GO:0030879)3.29085701
66positive regulation of mesonephros development (GO:0061213)3.28835364
67negative regulation of translation, ncRNA-mediated (GO:0040033)3.22967890
68regulation of translation, ncRNA-mediated (GO:0045974)3.22967890
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22967890
70toxin transport (GO:1901998)3.22539026
71cardiac muscle cell development (GO:0055013)3.12315911
72regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.10760081
73regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.10469377
74negative regulation of anoikis (GO:2000811)3.09965270
75positive regulation of action potential (GO:0045760)3.01842607
76adherens junction assembly (GO:0034333)2.97816925
77mesenchyme morphogenesis (GO:0072132)2.97165623
78negative regulation of myoblast differentiation (GO:0045662)2.95925838
79cardiac cell development (GO:0055006)2.94224101
80insulin-like growth factor receptor signaling pathway (GO:0048009)2.91623978
81synaptic vesicle docking involved in exocytosis (GO:0016081)2.85221893
82apical protein localization (GO:0045176)2.79197524
83regulation of mesonephros development (GO:0061217)2.78779786
84regulation of acyl-CoA biosynthetic process (GO:0050812)2.77770468
85anatomical structure arrangement (GO:0048532)2.76419374
86positive regulation of glycogen biosynthetic process (GO:0045725)2.74755982
87interkinetic nuclear migration (GO:0022027)2.73547477
88positive regulation of fatty acid oxidation (GO:0046321)2.73365413
89outflow tract septum morphogenesis (GO:0003148)2.72065982
90regulation of glomerulus development (GO:0090192)2.71400719
91cell-substrate junction assembly (GO:0007044)2.69925434
92female genitalia development (GO:0030540)2.67715184
93fusion of sperm to egg plasma membrane (GO:0007342)2.66283542
94negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.64427684
95embryonic epithelial tube formation (GO:0001838)2.61857189
96regulation of acrosome reaction (GO:0060046)2.60231466
97embryonic camera-type eye morphogenesis (GO:0048596)2.59858883
98regulation of anoikis (GO:2000209)2.54523943
99epithelial tube formation (GO:0072175)2.52049258
100fatty acid transport (GO:0015908)2.50880210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IKZF1_21737484_ChIP-ChIP_HCT116_Human4.19270530
2VDR_22108803_ChIP-Seq_LS180_Human3.53595824
3EZH2_22144423_ChIP-Seq_EOC_Human2.70079751
4ZNF217_24962896_ChIP-Seq_MCF-7_Human2.60596072
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.53060200
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.44682785
7DROSHA_22980978_ChIP-Seq_HELA_Human2.36000304
8AHR_22903824_ChIP-Seq_MCF-7_Human2.35201799
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.29554436
10TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.26092681
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.25042602
12ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.21755782
13ARNT_22903824_ChIP-Seq_MCF-7_Human2.20845879
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.18243613
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14273965
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.11818423
17CTNNB1_20460455_ChIP-Seq_HCT116_Human1.96180271
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93271611
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85307734
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76826964
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.69598053
22TP53_16413492_ChIP-PET_HCT116_Human1.66458706
23SMAD3_21741376_ChIP-Seq_HESCs_Human1.65620561
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.63498537
25NFIB_24661679_ChIP-Seq_LUNG_Mouse1.62853073
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51499398
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51499398
28WT1_25993318_ChIP-Seq_PODOCYTE_Human1.49268758
29SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48839252
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46525183
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.42056022
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41475800
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40775817
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38353133
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.38085567
36DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37113172
37SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37031795
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36825979
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35838279
40TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.35720509
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.34578103
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.34200037
43PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.33479192
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.32631188
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.32046970
46STAT1_20625510_ChIP-Seq_HELA_Human1.30895583
47SMAD4_21741376_ChIP-Seq_HESCs_Human1.30674261
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.29467686
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.29093699
50AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.28425807
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.27176630
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26063735
53RUNX2_22187159_ChIP-Seq_PCA_Human1.23630443
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20269803
55SCL_19346495_ChIP-Seq_HPC-7_Human1.18994972
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18237122
57CLOCK_20551151_ChIP-Seq_293T_Human1.17682142
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17563918
59AR_25329375_ChIP-Seq_VCAP_Human1.15978365
60CDX2_22108803_ChIP-Seq_LS180_Human1.15525094
61STAT3_23295773_ChIP-Seq_U87_Human1.14336236
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.13377438
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12555795
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10465947
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10310759
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09523742
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09019967
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.08978486
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08887319
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06027769
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05945636
72CEBPB_22108803_ChIP-Seq_LS180_Human1.05777586
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05046803
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04194394
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.03849751
76AR_21572438_ChIP-Seq_LNCaP_Human1.03563480
77KDM2B_26808549_Chip-Seq_K562_Human1.03248282
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02333193
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01751651
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01186358
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99986578
82OCT1_27270436_Chip-Seq_PROSTATE_Human0.99952169
83PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99639520
84SMAD4_21799915_ChIP-Seq_A2780_Human0.99371056
85TBX20_22080862_ChIP-Seq_HEART_Mouse0.98159894
86TBX20_22328084_ChIP-Seq_HEART_Mouse0.98159894
87AR_19668381_ChIP-Seq_PC3_Human0.96088550
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96062430
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95946724
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94979606
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94368892
92RING1B_27294783_Chip-Seq_NPCs_Mouse0.94176661
93KDM2B_26808549_Chip-Seq_REH_Human0.93742734
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92893982
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92693820
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91965097
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.91644173
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90980495
99TP53_23651856_ChIP-Seq_MEFs_Mouse0.90928138
100LXR_22292898_ChIP-Seq_THP-1_Human0.90632497

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.05447622
2MP0010386_abnormal_urinary_bladder5.64225826
3MP0008004_abnormal_stomach_pH4.93308454
4MP0002653_abnormal_ependyma_morphology4.00033517
5MP0000534_abnormal_ureter_morphology3.19038786
6MP0000538_abnormal_urinary_bladder2.88943663
7MP0003879_abnormal_hair_cell2.85162826
8MP0002282_abnormal_trachea_morphology2.76002280
9MP0002876_abnormal_thyroid_physiology2.51215140
10MP0005360_urolithiasis2.50231455
11MP0004036_abnormal_muscle_relaxation2.36978733
12MP0003938_abnormal_ear_development2.34911303
13MP0000767_abnormal_smooth_muscle2.30514288
14MP0005666_abnormal_adipose_tissue2.29259115
15MP0001664_abnormal_digestion2.28151075
16MP0001756_abnormal_urination2.26852052
17MP0000462_abnormal_digestive_system2.25414163
18MP0003045_fibrosis2.19421451
19MP0008961_abnormal_basal_metabolism2.09376767
20MP0005646_abnormal_pituitary_gland2.04216698
21MP0003566_abnormal_cell_adhesion1.89284305
22MP0005076_abnormal_cell_differentiation1.86662803
23MP0000013_abnormal_adipose_tissue1.82168220
24MP0002638_abnormal_pupillary_reflex1.78768995
25MP0001958_emphysema1.76959880
26MP0005375_adipose_tissue_phenotype1.76589005
27MP0001501_abnormal_sleep_pattern1.72006038
28MP0003942_abnormal_urinary_system1.63614105
29MP0000681_abnormal_thyroid_gland1.55990061
30MP0005620_abnormal_muscle_contractility1.52493763
31MP0001270_distended_abdomen1.52275553
32MP0000230_abnormal_systemic_arterial1.48472409
33MP0005595_abnormal_vascular_smooth1.47981381
34MP0004145_abnormal_muscle_electrophysio1.43330731
35MP0000566_synostosis1.37655558
36MP0000631_abnormal_neuroendocrine_gland1.35895263
37MP0003936_abnormal_reproductive_system1.35605043
38MP0003950_abnormal_plasma_membrane1.33690348
39MP0002168_other_aberrant_phenotype1.32301195
40MP0000049_abnormal_middle_ear1.23205846
41MP0002249_abnormal_larynx_morphology1.20712051
42MP0001727_abnormal_embryo_implantation1.18656586
43MP0000516_abnormal_urinary_system1.16763502
44MP0005367_renal/urinary_system_phenotyp1.16763502
45MP0001502_abnormal_circadian_rhythm1.16076411
46MP0001348_abnormal_lacrimal_gland1.14842808
47MP0005330_cardiomyopathy1.12015732
48MP0002332_abnormal_exercise_endurance1.08077723
49MP0000003_abnormal_adipose_tissue1.06602999
50MP0002127_abnormal_cardiovascular_syste1.04960711
51MP0008057_abnormal_DNA_replication1.00308641
52MP0010352_gastrointestinal_tract_polyps0.99924437
53MP0000163_abnormal_cartilage_morphology0.97844493
54MP0000751_myopathy0.97371133
55MP0009115_abnormal_fat_cell0.96839805
56MP0005381_digestive/alimentary_phenotyp0.96104715
57MP0008569_lethality_at_weaning0.95875747
58MP0002933_joint_inflammation0.94129526
59MP0005023_abnormal_wound_healing0.89912075
60MP0002009_preneoplasia0.89457256
61MP0001731_abnormal_postnatal_growth0.83215096
62MP0002108_abnormal_muscle_morphology0.82937392
63MP0000383_abnormal_hair_follicle0.79540836
64MP0002925_abnormal_cardiovascular_devel0.79413350
65MP0003705_abnormal_hypodermis_morpholog0.78684649
66MP0002115_abnormal_skeleton_extremities0.78662564
67MP0002116_abnormal_craniofacial_bone0.77128751
68MP0003935_abnormal_craniofacial_develop0.75458664
69MP0004130_abnormal_muscle_cell0.73164199
70MP0002896_abnormal_bone_mineralization0.71773576
71MP0004808_abnormal_hematopoietic_stem0.70960340
72MP0000026_abnormal_inner_ear0.66871640
73MP0000627_abnormal_mammary_gland0.65881163
74MP0002135_abnormal_kidney_morphology0.65396540
75MP0009780_abnormal_chondrocyte_physiolo0.65291447
76MP0003868_abnormal_feces_composition0.65178114
77MP0002109_abnormal_limb_morphology0.64083106
78MP0000537_abnormal_urethra_morphology0.64036928
79MP0005164_abnormal_response_to0.63310252
80MP0003953_abnormal_hormone_level0.62260337
81MP0002932_abnormal_joint_morphology0.61842502
82MP0004858_abnormal_nervous_system0.61473419
83MP0001614_abnormal_blood_vessel0.60910449
84MP0001968_abnormal_touch/_nociception0.60558910
85MP0004087_abnormal_muscle_fiber0.59341376
86MP0001175_abnormal_lung_morphology0.58188974
87MP0004084_abnormal_cardiac_muscle0.58125522
88MP0001984_abnormal_olfaction0.58030435
89MP0001485_abnormal_pinna_reflex0.57942609
90MP0005332_abnormal_amino_acid0.57767085
91MP0008875_abnormal_xenobiotic_pharmacok0.56701112
92MP0002114_abnormal_axial_skeleton0.55863954
93MP0000778_abnormal_nervous_system0.54410378
94MP0003279_aneurysm0.53670973
95MP0000432_abnormal_head_morphology0.52347408
96MP0003137_abnormal_impulse_conducting0.52025749
97MP0010770_preweaning_lethality0.51981021
98MP0002082_postnatal_lethality0.51981021
99MP0004185_abnormal_adipocyte_glucose0.50676120
100MP0000266_abnormal_heart_morphology0.50253487

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)8.24344708
2Progressive cerebellar ataxia (HP:0002073)7.97229899
3Abnormality of the axillary hair (HP:0100134)5.62387313
4Abnormality of secondary sexual hair (HP:0009888)5.62387313
5Aortic dissection (HP:0002647)5.57151499
6Shawl scrotum (HP:0000049)5.26911782
7Sparse lateral eyebrow (HP:0005338)4.93218565
8Genetic anticipation (HP:0003743)4.47328905
9Thyroid-stimulating hormone excess (HP:0002925)4.33651133
10Neoplasm of the heart (HP:0100544)4.21345911
11Facial shape deformation (HP:0011334)4.13575222
12Potter facies (HP:0002009)4.13575222
13Aplasia of the musculature (HP:0100854)4.04788027
14Breast hypoplasia (HP:0003187)3.95121761
15Bronchomalacia (HP:0002780)3.92191857
16Dysmetric saccades (HP:0000641)3.89691614
17Hypoplastic nipples (HP:0002557)3.82469077
18Aortic regurgitation (HP:0001659)3.65627049
19Hypothermia (HP:0002045)3.63501505
20Cerebral palsy (HP:0100021)3.54739065
21Growth hormone excess (HP:0000845)3.41269168
22Anal stenosis (HP:0002025)3.29360381
23Laryngomalacia (HP:0001601)3.22238349
24Hyperpituitarism (HP:0010514)3.15391136
25Broad face (HP:0000283)3.00880226
26Malnutrition (HP:0004395)2.94418587
27Clubbing of toes (HP:0100760)2.85104032
28Limb ataxia (HP:0002070)2.84199245
29Prolonged QT interval (HP:0001657)2.81697569
30Seborrheic dermatitis (HP:0001051)2.78791734
31Hyperventilation (HP:0002883)2.68989052
32Aplasia/Hypoplasia of the scapulae (HP:0006713)2.66184354
33Hypoplastic scapulae (HP:0000882)2.66184354
34Short clavicles (HP:0000894)2.60039445
35Urethral obstruction (HP:0000796)2.55130714
36Absent hand (HP:0004050)2.54646167
37Short humerus (HP:0005792)2.52306216
38Abnormality of abdominal situs (HP:0011620)2.48010909
39Abdominal situs inversus (HP:0003363)2.48010909
40Abnormality of macular pigmentation (HP:0008002)2.47017994
41Obstructive sleep apnea (HP:0002870)2.43691936
42Aneurysm (HP:0002617)2.42640101
43Supernumerary ribs (HP:0005815)2.40398187
44Bicornuate uterus (HP:0000813)2.35277418
45Chorioretinal atrophy (HP:0000533)2.35076115
46Shallow orbits (HP:0000586)2.33517900
47Abnormality of the distal phalanx of the thumb (HP:0009617)2.33052404
48Tracheomalacia (HP:0002779)2.31050130
49Aplasia/Hypoplasia of the clavicles (HP:0006710)2.27103485
50Hemorrhage of the eye (HP:0011885)2.26356253
51Absent radius (HP:0003974)2.26116715
52Supernumerary bones of the axial skeleton (HP:0009144)2.24214278
53Midline defect of the nose (HP:0004122)2.23223141
54Aplasia/hypoplasia of the humerus (HP:0006507)2.21914548
55Ureteral stenosis (HP:0000071)2.18664650
56Renal dysplasia (HP:0000110)2.17904714
57Protruding tongue (HP:0010808)2.16753951
58Long toe (HP:0010511)2.16601935
59Abnormality of the fingertips (HP:0001211)2.15237128
60Gonadotropin excess (HP:0000837)2.15136345
61Macroglossia (HP:0000158)2.13174679
62Hypoplasia of the ulna (HP:0003022)2.11608374
63Aplasia involving forearm bones (HP:0009822)2.11190221
64Absent forearm bone (HP:0003953)2.11190221
65Optic nerve coloboma (HP:0000588)2.10542260
66Abnormality of the nasal septum (HP:0000419)2.08466893
67Bicuspid aortic valve (HP:0001647)2.07173073
68Pigmentary retinal degeneration (HP:0001146)2.06109441
69Clumsiness (HP:0002312)2.02080310
70Ureteral obstruction (HP:0006000)1.99771652
71Sandal gap (HP:0001852)1.96584583
72Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96179169
73Gaze-evoked nystagmus (HP:0000640)1.94258455
74Hypoplastic labia majora (HP:0000059)1.92574673
75Hip contracture (HP:0003273)1.91730767
76Morphological abnormality of the pyramidal tract (HP:0002062)1.88889777
77Polydipsia (HP:0001959)1.87771984
78Abnormal drinking behavior (HP:0030082)1.87771984
79Hydroureter (HP:0000072)1.87687206
80Overgrowth (HP:0001548)1.82882794
81Neonatal short-limb short stature (HP:0008921)1.82750684
82Aplasia/Hypoplasia of the ulna (HP:0006495)1.81674180
83Genu varum (HP:0002970)1.78467993
84Bradycardia (HP:0001662)1.76540391
85Vertebral arch anomaly (HP:0008438)1.76468527
86Long eyelashes (HP:0000527)1.76412842
87Hoarse voice (HP:0001609)1.75953519
88Broad-based gait (HP:0002136)1.74838507
89Decreased circulating renin level (HP:0003351)1.72589422
90Abnormality of the labia majora (HP:0012881)1.72376161
91Focal segmental glomerulosclerosis (HP:0000097)1.71890714
92Pulmonary artery stenosis (HP:0004415)1.71344958
93Rectal prolapse (HP:0002035)1.71206729
94Tented upper lip vermilion (HP:0010804)1.70384962
95Neonatal hypoglycemia (HP:0001998)1.69548818
96Fair hair (HP:0002286)1.68405830
97Limited hip movement (HP:0008800)1.65908018
98Persistence of primary teeth (HP:0006335)1.65860052
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62044705
100Macular degeneration (HP:0000608)1.60916783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG6.51574448
2MYLK5.59319644
3DMPK2.95252197
4CDK122.67722851
5RIPK12.24541086
6AKT310.8261029
7FRK1.89768328
8PAK21.88697505
9TRIB31.72817548
10EEF2K1.71834158
11CDC42BPA1.59877812
12CAMK1D1.50136634
13ACVR1B1.44011556
14TAOK31.42556006
15LATS11.40073402
16TTN1.34879747
17CAMK1G1.27874975
18PIK3CA1.25408178
19TNK21.19470831
20MARK21.14373006
21PAK31.06784562
22MAP3K71.04862209
23MTOR1.04061600
24BMPR1B0.97898882
25NLK0.94579579
26STK380.92745074
27BRD40.88093519
28HIPK20.85092164
29TNIK0.78027792
30CHUK0.68610530
31MAPKAPK30.68219685
32PRKAA20.66296609
33ROCK10.66079717
34DDR20.65786563
35TRPM70.64513904
36RPS6KA20.60950502
37SIK10.56763314
38SGK20.55218628
39CAMK10.54786649
40EPHA30.54776525
41FER0.53313471
42TGFBR10.51712284
43MAPK10.51489490
44MAPK40.48985921
45MAPK80.48200054
46MARK10.45456392
47MAPKAPK50.45132799
48NME10.44123068
49MAP3K20.44070515
50MAPK70.44011792
51CAMK40.43226945
52MAP2K10.42083882
53PDGFRA0.42067536
54MAPK120.41955665
55FGFR20.38370653
56PRKD20.35952871
57MAP3K130.35404330
58MELK0.35227417
59MAP2K20.34188833
60GSK3B0.33689908
61RET0.33052447
62SGK4940.32875825
63SGK2230.32875825
64EPHB10.32580777
65MAPK30.32548912
66RPS6KA60.32443804
67PDGFRB0.32331631
68PRKAA10.31538226
69MAPK90.29258597
70SGK30.28980871
71PRKACB0.28321653
72STK38L0.27506021
73INSRR0.27386948
74MKNK20.26970237
75GSK3A0.26356348
76RPS6KC10.25651132
77RPS6KL10.25651132
78MAPKAPK20.25105035
79ICK0.24579716
80ERN10.24364237
81MAPK130.22922746
82WNK10.22039808
83MAPK100.21667195
84RPS6KA30.21380701
85PRKG10.20075468
86MAPK140.19712115
87ILK0.16217222
88RPS6KA10.16168714
89AKT10.16116031
90PAK10.15482764
91CAMK2G0.15310623
92RPS6KA50.14831518
93MKNK10.14772233
94MAPK110.14593679
95CDK10.14108111
96SGK10.14067383
97PTK2B0.13650879
98PRKDC0.13516363
99PRKCH0.13327741
100CDK20.12543259

Predicted pathways (KEGG)

RankGene SetZ-score
1Arachidonic acid metabolism_Homo sapiens_hsa005904.96873340
2Vascular smooth muscle contraction_Homo sapiens_hsa042703.49518141
3Fatty acid biosynthesis_Homo sapiens_hsa000612.83675543
4Circadian rhythm_Homo sapiens_hsa047102.49821807
5Lysine degradation_Homo sapiens_hsa003102.17061672
6Adherens junction_Homo sapiens_hsa045202.15369435
7Gastric acid secretion_Homo sapiens_hsa049711.84507819
8Focal adhesion_Homo sapiens_hsa045101.62140941
9cGMP-PKG signaling pathway_Homo sapiens_hsa040221.54868931
10Tight junction_Homo sapiens_hsa045301.52891228
11Notch signaling pathway_Homo sapiens_hsa043301.51883793
12Oxytocin signaling pathway_Homo sapiens_hsa049211.46080185
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40947476
14Thyroid cancer_Homo sapiens_hsa052161.38882197
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38046608
16Inositol phosphate metabolism_Homo sapiens_hsa005621.37475436
17Dilated cardiomyopathy_Homo sapiens_hsa054141.37355090
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35705292
19Thyroid hormone synthesis_Homo sapiens_hsa049181.34579422
20Salivary secretion_Homo sapiens_hsa049701.34250666
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28096228
22Circadian entrainment_Homo sapiens_hsa047131.25040978
23Insulin secretion_Homo sapiens_hsa049111.23439943
24Pancreatic secretion_Homo sapiens_hsa049721.20342081
25Prostate cancer_Homo sapiens_hsa052151.16218766
26Protein digestion and absorption_Homo sapiens_hsa049741.16022330
27ECM-receptor interaction_Homo sapiens_hsa045121.14103360
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13488885
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10210831
30PPAR signaling pathway_Homo sapiens_hsa033201.10025726
31Acute myeloid leukemia_Homo sapiens_hsa052211.09641482
32Proteoglycans in cancer_Homo sapiens_hsa052051.08938847
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07411910
34Calcium signaling pathway_Homo sapiens_hsa040201.07248395
35Renin secretion_Homo sapiens_hsa049241.06720497
36Taste transduction_Homo sapiens_hsa047421.06680493
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04979727
38Platelet activation_Homo sapiens_hsa046111.04001048
39Estrogen signaling pathway_Homo sapiens_hsa049151.01741298
40Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99210132
41Choline metabolism in cancer_Homo sapiens_hsa052310.97331589
42Insulin resistance_Homo sapiens_hsa049310.96197983
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.95260964
44Dorso-ventral axis formation_Homo sapiens_hsa043200.94866304
45Cholinergic synapse_Homo sapiens_hsa047250.94774340
46Melanogenesis_Homo sapiens_hsa049160.94101764
47beta-Alanine metabolism_Homo sapiens_hsa004100.94034846
48TGF-beta signaling pathway_Homo sapiens_hsa043500.93591608
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91813838
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91031199
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90512754
52Prolactin signaling pathway_Homo sapiens_hsa049170.90249890
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89974506
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89339014
55Ovarian steroidogenesis_Homo sapiens_hsa049130.89077114
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88781530
57Small cell lung cancer_Homo sapiens_hsa052220.87526515
58AMPK signaling pathway_Homo sapiens_hsa041520.84099119
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83951580
60VEGF signaling pathway_Homo sapiens_hsa043700.82482521
61mTOR signaling pathway_Homo sapiens_hsa041500.80767836
62Amoebiasis_Homo sapiens_hsa051460.80705196
63Long-term potentiation_Homo sapiens_hsa047200.77627349
64FoxO signaling pathway_Homo sapiens_hsa040680.76401300
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74450639
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74441843
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.73889135
68Glucagon signaling pathway_Homo sapiens_hsa049220.73729482
69cAMP signaling pathway_Homo sapiens_hsa040240.72960652
70TNF signaling pathway_Homo sapiens_hsa046680.72598535
71GnRH signaling pathway_Homo sapiens_hsa049120.70203964
72Serotonergic synapse_Homo sapiens_hsa047260.70066364
73Hippo signaling pathway_Homo sapiens_hsa043900.69432293
74Histidine metabolism_Homo sapiens_hsa003400.69179098
75Basal cell carcinoma_Homo sapiens_hsa052170.67297822
76Long-term depression_Homo sapiens_hsa047300.66753965
77MicroRNAs in cancer_Homo sapiens_hsa052060.64445165
78Pathways in cancer_Homo sapiens_hsa052000.63014879
79Wnt signaling pathway_Homo sapiens_hsa043100.59924014
80Type II diabetes mellitus_Homo sapiens_hsa049300.59144325
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57721840
82ABC transporters_Homo sapiens_hsa020100.55826721
83Insulin signaling pathway_Homo sapiens_hsa049100.55227790
84Glioma_Homo sapiens_hsa052140.53491074
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.53274367
86MAPK signaling pathway_Homo sapiens_hsa040100.53149980
87Fructose and mannose metabolism_Homo sapiens_hsa000510.52151017
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49362572
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.48014611
90Non-small cell lung cancer_Homo sapiens_hsa052230.47907814
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46059751
92Dopaminergic synapse_Homo sapiens_hsa047280.45984779
93HIF-1 signaling pathway_Homo sapiens_hsa040660.44579284
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44225163
95Hepatitis C_Homo sapiens_hsa051600.43257914
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.41391148
97Glutamatergic synapse_Homo sapiens_hsa047240.39901856
98ErbB signaling pathway_Homo sapiens_hsa040120.38701056
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37239177
100Renal cell carcinoma_Homo sapiens_hsa052110.35595090

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