SENP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)6.13807541
2doxorubicin metabolic process (GO:0044598)6.13807541
3daunorubicin metabolic process (GO:0044597)6.13807541
4protein localization to kinetochore (GO:0034501)5.84153208
5nuclear pore complex assembly (GO:0051292)5.23494008
6regulation of nuclear cell cycle DNA replication (GO:0033262)5.09430209
7protein localization to chromosome, centromeric region (GO:0071459)4.85774703
8mitotic sister chromatid segregation (GO:0000070)4.85129092
9regulation of centriole replication (GO:0046599)4.84708691
10nuclear pore organization (GO:0006999)4.78702984
11somatic hypermutation of immunoglobulin genes (GO:0016446)4.72862056
12somatic diversification of immune receptors via somatic mutation (GO:0002566)4.72862056
13regulation of telomere maintenance via telomerase (GO:0032210)4.56893285
14negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.55001657
15sister chromatid segregation (GO:0000819)4.40152279
16positive regulation of DNA-dependent DNA replication (GO:2000105)4.35614016
17negative regulation of cell cycle G2/M phase transition (GO:1902750)4.31679032
18DNA replication checkpoint (GO:0000076)4.29724160
19negative regulation of fibroblast apoptotic process (GO:2000270)4.16923144
20double-strand break repair via nonhomologous end joining (GO:0006303)4.15226647
21non-recombinational repair (GO:0000726)4.15226647
22mitotic chromosome condensation (GO:0007076)4.10957576
23DNA topological change (GO:0006265)4.05874304
24pore complex assembly (GO:0046931)4.05040027
25histone H4-K12 acetylation (GO:0043983)3.99789647
26regulation of DNA endoreduplication (GO:0032875)3.90326233
27DNA replication-dependent nucleosome organization (GO:0034723)3.88862703
28DNA replication-dependent nucleosome assembly (GO:0006335)3.88862703
29DNA double-strand break processing (GO:0000729)3.88820196
30maintenance of protein location in nucleus (GO:0051457)3.84943088
31regulation of mammary gland epithelial cell proliferation (GO:0033599)3.83353276
32heterochromatin organization (GO:0070828)3.82044162
33negative regulation of telomerase activity (GO:0051974)3.80998667
34histone H4-K5 acetylation (GO:0043981)3.73833265
35histone H4-K8 acetylation (GO:0043982)3.73833265
36regulation of sister chromatid cohesion (GO:0007063)3.69621710
37aminoglycoside antibiotic metabolic process (GO:0030647)3.69148143
38negative regulation of epidermis development (GO:0045683)3.66216996
39chromatin assembly (GO:0031497)3.64113618
40telomere maintenance via recombination (GO:0000722)3.63273035
41DNA ligation (GO:0006266)3.62431961
42regulation of RNA export from nucleus (GO:0046831)3.58621615
43interferon-gamma production (GO:0032609)3.58259056
44somite rostral/caudal axis specification (GO:0032525)3.55257583
45histone H2A acetylation (GO:0043968)3.55134740
46positive regulation of chromosome segregation (GO:0051984)3.50518630
47establishment of integrated proviral latency (GO:0075713)3.50302848
48DNA duplex unwinding (GO:0032508)3.47656762
49somatic recombination of immunoglobulin gene segments (GO:0016447)3.47448155
50DNA geometric change (GO:0032392)3.45766312
51DNA unwinding involved in DNA replication (GO:0006268)3.44137547
52regulation of centrosome cycle (GO:0046605)3.43722824
53negative regulation of telomere maintenance (GO:0032205)3.41988595
54pre-miRNA processing (GO:0031054)3.41250844
55DNA replication initiation (GO:0006270)3.39904751
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.37700013
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.37700013
58positive regulation of mitotic sister chromatid separation (GO:1901970)3.37700013
59DNA strand renaturation (GO:0000733)3.37143744
60spindle checkpoint (GO:0031577)3.37136552
61regulation of chromosome segregation (GO:0051983)3.37075968
62regulation of centrosome duplication (GO:0010824)3.36816660
63mitotic nuclear envelope disassembly (GO:0007077)3.36677584
64sister chromatid cohesion (GO:0007062)3.36628297
65rRNA transcription (GO:0009303)3.35438992
66somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.34323470
67somatic cell DNA recombination (GO:0016444)3.34323470
68histone exchange (GO:0043486)3.34031635
69mitotic sister chromatid cohesion (GO:0007064)3.33631129
70DNA synthesis involved in DNA repair (GO:0000731)3.31155660
71centriole replication (GO:0007099)3.30746487
72ATP-dependent chromatin remodeling (GO:0043044)3.29229008
73regulation of response to osmotic stress (GO:0047484)3.27677348
74negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.25927771
75N-terminal protein amino acid acetylation (GO:0006474)3.24969881
76mRNA stabilization (GO:0048255)3.24277021
77RNA stabilization (GO:0043489)3.24277021
78somatic diversification of immunoglobulins (GO:0016445)3.23494435
79mitotic spindle checkpoint (GO:0071174)3.23151850
80negative regulation of DNA recombination (GO:0045910)3.22274779
81negative regulation of DNA-dependent DNA replication (GO:2000104)3.21008269
82synapsis (GO:0007129)3.20245589
83regulation of mitotic metaphase/anaphase transition (GO:0030071)3.19425777
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.19425777
85somatic diversification of immune receptors (GO:0002200)3.18117285
86meiotic chromosome segregation (GO:0045132)3.17967364
87regulation of DNA-dependent DNA replication (GO:0090329)3.17892028
88negative regulation of chromosome segregation (GO:0051985)3.17879983
89negative regulation of DNA repair (GO:0045738)3.17648729
90regulation of helicase activity (GO:0051095)3.17025444
91notochord development (GO:0030903)3.15889302
92regulation of translation in response to stress (GO:0043555)3.15850626
93regulation of telomere maintenance (GO:0032204)3.15060678
94DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.14555900
95protein localization to chromosome (GO:0034502)3.14440727
96regulation of double-strand break repair (GO:2000779)3.12613763
97regulation of sister chromatid segregation (GO:0033045)3.12464530
98regulation of mitotic sister chromatid separation (GO:0010965)3.12464530
99regulation of mitotic sister chromatid segregation (GO:0033047)3.12464530
100histone H4-K16 acetylation (GO:0043984)3.11647244
101attachment of spindle microtubules to kinetochore (GO:0008608)3.11317637
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11246284
103folic acid-containing compound biosynthetic process (GO:0009396)3.10989093
104microtubule depolymerization (GO:0007019)3.08815106
105negative regulation of mitotic sister chromatid separation (GO:2000816)3.07658352
106negative regulation of sister chromatid segregation (GO:0033046)3.07658352
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07658352
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07658352
109negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07658352
110regulation of spindle organization (GO:0090224)3.07282398
111mitotic metaphase plate congression (GO:0007080)3.07138497
112nuclear envelope disassembly (GO:0051081)3.06113306
113membrane disassembly (GO:0030397)3.06113306
114chromatin assembly or disassembly (GO:0006333)3.04465488
115regulation of MHC class I biosynthetic process (GO:0045343)3.02862048
116DNA conformation change (GO:0071103)3.00071897
117kinetochore organization (GO:0051383)2.99016621
118histone H3-K4 methylation (GO:0051568)2.98257131
119DNA damage response, signal transduction resulting in transcription (GO:0042772)2.97618144
120negative regulation of epidermal cell differentiation (GO:0045605)2.97272950
121spindle assembly (GO:0051225)2.94074697
122regulation of double-strand break repair via homologous recombination (GO:0010569)2.87636204
123rRNA methylation (GO:0031167)2.85051266
124muscle organ morphogenesis (GO:0048644)2.81796462
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81223186
126chromosome condensation (GO:0030261)2.81162565
127metaphase plate congression (GO:0051310)2.79138637
128mitotic G2/M transition checkpoint (GO:0044818)2.78943056
129chromosome segregation (GO:0007059)2.74378258
130kinetochore assembly (GO:0051382)2.72892570
131intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.68864757
132replication fork processing (GO:0031297)2.67981509
133DNA packaging (GO:0006323)2.67588263
134rRNA modification (GO:0000154)2.66928335
135regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.65705202
136regulation of histone H3-K9 methylation (GO:0051570)2.63451492
137DNA replication-independent nucleosome organization (GO:0034724)2.62047337
138DNA replication-independent nucleosome assembly (GO:0006336)2.62047337
139ribosome biogenesis (GO:0042254)2.58909268
140positive regulation of defense response to virus by host (GO:0002230)2.58520960
141DNA strand elongation involved in DNA replication (GO:0006271)2.58406030
142protein K6-linked ubiquitination (GO:0085020)2.56764115
143negative regulation of gene silencing (GO:0060969)2.56425408
144mitotic recombination (GO:0006312)2.54810119
145regulation of chromatin silencing (GO:0031935)2.54284889
146chromatin remodeling at centromere (GO:0031055)2.54267544
147spindle assembly checkpoint (GO:0071173)2.53770558
148negative regulation of phagocytosis (GO:0050765)2.53439497
149establishment of chromosome localization (GO:0051303)2.53054895
150DNA strand elongation (GO:0022616)2.52878793
151trophectodermal cell differentiation (GO:0001829)2.52808333
152CENP-A containing nucleosome assembly (GO:0034080)2.52516203
153positive regulation of protein deacetylation (GO:0090312)2.52107414
154formation of translation preinitiation complex (GO:0001731)2.49931763
155telomere maintenance via semi-conservative replication (GO:0032201)2.49925312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.71432756
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.71395178
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.61177058
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16369942
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.89376744
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.89376744
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.89376744
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.62204430
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40810520
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62647487
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.37224891
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.33806592
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25906734
14MYC_22102868_ChIP-Seq_BL_Human2.11838682
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.09201172
16* GABP_17652178_ChIP-ChIP_JURKAT_Human2.06916401
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04683067
18* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.00742772
19* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85535035
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83065337
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82028289
22FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81170002
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.78405363
24FUS_26573619_Chip-Seq_HEK293_Human1.77665055
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.75940677
26EWS_26573619_Chip-Seq_HEK293_Human1.74057053
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.72078104
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66369355
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64758071
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64698841
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.63805541
32SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.61691657
33SCL_19346495_ChIP-Seq_HPC-7_Human1.60784979
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59738191
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59173775
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58306199
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52467580
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51491798
39AR_21909140_ChIP-Seq_LNCAP_Human1.49825665
40* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49016866
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48965565
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.48250514
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47869876
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47111377
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44031254
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43733072
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.41622454
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41036180
49NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35795236
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35588348
51CIITA_25753668_ChIP-Seq_RAJI_Human1.35139012
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34532243
53IRF1_19129219_ChIP-ChIP_H3396_Human1.33880404
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33430280
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32613728
56* FOXP3_21729870_ChIP-Seq_TREG_Human1.31958256
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.31822709
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.31704281
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30629929
60DCP1A_22483619_ChIP-Seq_HELA_Human1.29871958
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28454511
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28366300
63ZNF274_21170338_ChIP-Seq_K562_Hela1.26864849
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24766444
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24550793
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24245609
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22603470
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21940607
69NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.21806483
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20238766
71* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18755175
72* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18120628
73TCF7_22412390_ChIP-Seq_EML_Mouse1.15720384
74* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15668093
75MYB_26560356_Chip-Seq_TH1_Human1.15416437
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15129285
77VDR_22108803_ChIP-Seq_LS180_Human1.15085366
78KDM5A_27292631_Chip-Seq_BREAST_Human1.13716523
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13697226
80VDR_23849224_ChIP-Seq_CD4+_Human1.09879477
81SPI1_23547873_ChIP-Seq_NB4_Human1.09688208
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09588222
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09230839
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.08423976
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05797285
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05646426
87* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04586804
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03910707
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.03824427
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03528182
91MYB_26560356_Chip-Seq_TH2_Human1.03099411
92TAF15_26573619_Chip-Seq_HEK293_Human1.02616319
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02134441
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00913831
95POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00368770
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00277220
97TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99759129
98HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99025461
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97994875
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97969734
101* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97424721
102XRN2_22483619_ChIP-Seq_HELA_Human0.97147835
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97116867
104FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94997443
105ELK1_19687146_ChIP-ChIP_HELA_Human0.94857165
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94836128
107* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94441152
108VDR_21846776_ChIP-Seq_THP-1_Human0.94283992
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.93948397
110ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93387577
111IRF8_21731497_ChIP-ChIP_J774_Mouse0.92792192
112TTF2_22483619_ChIP-Seq_HELA_Human0.90814964
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90339170
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.89602271
115MYC_18940864_ChIP-ChIP_HL60_Human0.88485233
116ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87770671
117* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.87114254
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.86267346
119* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86155388
120PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85916112
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85646166
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.85253736
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.85223190
124NCOR1_26117541_ChIP-Seq_K562_Human0.85009748
125PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84996219
126* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84956969
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84869366
128GATA1_22025678_ChIP-Seq_K562_Human0.84867146
129* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84400975
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84203958
131MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.83862723
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83317144
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83103734
134IGF1R_20145208_ChIP-Seq_DFB_Human0.82103441
135PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82088917
136HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81758249
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81715061
138KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81674138
139TFEB_21752829_ChIP-Seq_HELA_Human0.81165257
140MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81005424
141SOX2_16153702_ChIP-ChIP_HESCs_Human0.80695856
142UTX_26944678_Chip-Seq_JUKART_Human0.80493927
143* GABP_19822575_ChIP-Seq_HepG2_Human0.80438968
144FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.80180480
145MAF_26560356_Chip-Seq_TH1_Human0.79832809
146CHD1_26751641_Chip-Seq_LNCaP_Human0.79812098
147FLI1_27457419_Chip-Seq_LIVER_Mouse0.77457536
148RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75798758
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75789589
150SRF_21415370_ChIP-Seq_HL-1_Mouse0.75672163
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.74686789
152P300_19829295_ChIP-Seq_ESCs_Human0.73782872
153ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.73477128
154SOX9_26525672_Chip-Seq_HEART_Mouse0.72708590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.30453723
2MP0010094_abnormal_chromosome_stability3.17888327
3MP0006292_abnormal_olfactory_placode3.01241103
4MP0004957_abnormal_blastocyst_morpholog2.96635429
5MP0003111_abnormal_nucleus_morphology2.88253738
6MP0004264_abnormal_extraembryonic_tissu2.87023694
7MP0009697_abnormal_copulation2.85067011
8MP0003077_abnormal_cell_cycle2.77119137
9MP0002396_abnormal_hematopoietic_system2.75844131
10MP0003693_abnormal_embryo_hatching2.60766257
11MP0003890_abnormal_embryonic-extraembry2.39909521
12MP0003121_genomic_imprinting2.28719741
13MP0005075_abnormal_melanosome_morpholog2.21162055
14MP0002254_reproductive_system_inflammat2.20702067
15MP0010352_gastrointestinal_tract_polyps2.18052586
16MP0008007_abnormal_cellular_replicative2.02976731
17MP0008058_abnormal_DNA_repair2.01923039
18MP0000490_abnormal_crypts_of1.85563863
19MP0000350_abnormal_cell_proliferation1.85302707
20MP0000566_synostosis1.85096013
21MP0001672_abnormal_embryogenesis/_devel1.82961892
22MP0005380_embryogenesis_phenotype1.82961892
23MP0003011_delayed_dark_adaptation1.72621025
24MP0003984_embryonic_growth_retardation1.68467724
25MP0002088_abnormal_embryonic_growth/wei1.67398774
26MP0005499_abnormal_olfactory_system1.64472078
27MP0005394_taste/olfaction_phenotype1.64472078
28MP0004808_abnormal_hematopoietic_stem1.55926024
29MP0003950_abnormal_plasma_membrane1.54724036
30MP0003718_maternal_effect1.53046093
31MP0000569_abnormal_digit_pigmentation1.52953198
32MP0003787_abnormal_imprinting1.50743655
33MP0009672_abnormal_birth_weight1.50121522
34MP0001293_anophthalmia1.49999792
35MP0003123_paternal_imprinting1.47724298
36MP0005257_abnormal_intraocular_pressure1.42963379
37MP0002009_preneoplasia1.41002354
38MP0000372_irregular_coat_pigmentation1.40996607
39MP0003122_maternal_imprinting1.39149661
40* MP0002086_abnormal_extraembryonic_tissu1.37196779
41MP0002085_abnormal_embryonic_tissue1.36347921
42MP0008932_abnormal_embryonic_tissue1.36304802
43MP0003943_abnormal_hepatobiliary_system1.36231324
44MP0003567_abnormal_fetal_cardiomyocyte1.36181808
45MP0001835_abnormal_antigen_presentation1.32637232
46MP0003763_abnormal_thymus_physiology1.28935428
47MP0004233_abnormal_muscle_weight1.26439930
48MP0002084_abnormal_developmental_patter1.24744307
49MP0002653_abnormal_ependyma_morphology1.22801072
50MP0001730_embryonic_growth_arrest1.22057047
51* MP0000313_abnormal_cell_death1.21447215
52* MP0002398_abnormal_bone_marrow1.20707749
53MP0000703_abnormal_thymus_morphology1.20314629
54MP0003786_premature_aging1.20218467
55MP0000678_abnormal_parathyroid_gland1.20132686
56MP0001697_abnormal_embryo_size1.19811112
57MP0002102_abnormal_ear_morphology1.19373264
58MP0002277_abnormal_respiratory_mucosa1.19330492
59MP0001800_abnormal_humoral_immune1.18290556
60MP0010307_abnormal_tumor_latency1.17604907
61MP0008877_abnormal_DNA_methylation1.15304468
62MP0002722_abnormal_immune_system1.13615280
63MP0002019_abnormal_tumor_incidence1.11832476
64MP0010030_abnormal_orbit_morphology1.11715136
65MP0005671_abnormal_response_to1.11650600
66MP0005408_hypopigmentation1.11548633
67MP0002132_abnormal_respiratory_system1.11431511
68MP0001286_abnormal_eye_development1.11297171
69MP0000689_abnormal_spleen_morphology1.10849770
70MP0002092_abnormal_eye_morphology1.07343026
71MP0001346_abnormal_lacrimal_gland1.06738892
72* MP0004197_abnormal_fetal_growth/weight/1.05867134
73MP0000432_abnormal_head_morphology1.05259195
74MP0002932_abnormal_joint_morphology1.04791282
75MP0006082_CNS_inflammation1.03278880
76MP0001849_ear_inflammation1.03272276
77MP0003705_abnormal_hypodermis_morpholog1.01736081
78MP0003938_abnormal_ear_development1.01358506
79* MP0002080_prenatal_lethality0.99413187
80MP0002938_white_spotting0.98485785
81MP0002405_respiratory_system_inflammati0.97820656
82MP0005397_hematopoietic_system_phenotyp0.97482666
83MP0001545_abnormal_hematopoietic_system0.97482666
84MP0010678_abnormal_skin_adnexa0.95016689
85MP0003221_abnormal_cardiomyocyte_apopto0.94395665
86MP0002127_abnormal_cardiovascular_syste0.94326783
87* MP0000716_abnormal_immune_system0.93366970
88MP0003183_abnormal_peptide_metabolism0.93073624
89MP0005076_abnormal_cell_differentiation0.92660648
90* MP0002429_abnormal_blood_cell0.92642845
91MP0003935_abnormal_craniofacial_develop0.90631925
92MP0002332_abnormal_exercise_endurance0.90193646
93MP0000383_abnormal_hair_follicle0.88947180
94MP0006035_abnormal_mitochondrial_morpho0.88259836
95MP0002697_abnormal_eye_size0.88000008
96MP0000428_abnormal_craniofacial_morphol0.87382636
97MP0002452_abnormal_antigen_presenting0.87294587
98MP0000049_abnormal_middle_ear0.86273598
99MP0002420_abnormal_adaptive_immunity0.85559883
100MP0005387_immune_system_phenotype0.85438152
101MP0001790_abnormal_immune_system0.85438152
102MP0002877_abnormal_melanocyte_morpholog0.85267636
103MP0000858_altered_metastatic_potential0.85089401
104MP0001819_abnormal_immune_cell0.85030913
105MP0002114_abnormal_axial_skeleton0.84701210
106MP0000427_abnormal_hair_cycle0.84287947
107MP0000653_abnormal_sex_gland0.84072245
108MP0003937_abnormal_limbs/digits/tail_de0.83205528
109MP0003861_abnormal_nervous_system0.82973498
110MP0009703_decreased_birth_body0.82355990
111MP0002210_abnormal_sex_determination0.82349912
112MP0008789_abnormal_olfactory_epithelium0.81253982
113MP0005621_abnormal_cell_physiology0.80729269
114MP0005384_cellular_phenotype0.80617592
115MP0001915_intracranial_hemorrhage0.80517493
116MP0001529_abnormal_vocalization0.79905130
117MP0003448_altered_tumor_morphology0.79628858
118MP0000685_abnormal_immune_system0.79532721
119* MP0002925_abnormal_cardiovascular_devel0.79138989
120MP0003941_abnormal_skin_development0.79106805
121MP0005083_abnormal_biliary_tract0.78607275
122MP0003656_abnormal_erythrocyte_physiolo0.78527413
123MP0000647_abnormal_sebaceous_gland0.78082828
124MP0008961_abnormal_basal_metabolism0.77661774
125MP0002075_abnormal_coat/hair_pigmentati0.77525444
126MP0001145_abnormal_male_reproductive0.77420731
127MP0001661_extended_life_span0.77065681
128MP0002723_abnormal_immune_serum0.76662859
129MP0009278_abnormal_bone_marrow0.76380085
130MP0003115_abnormal_respiratory_system0.75882611
131MP0004185_abnormal_adipocyte_glucose0.75540897
132MP0003755_abnormal_palate_morphology0.75259474
133MP0009333_abnormal_splenocyte_physiolog0.75107572
134MP0000358_abnormal_cell_content/0.74749619
135MP0001929_abnormal_gametogenesis0.71756945
136MP0002233_abnormal_nose_morphology0.71612369
137MP0003698_abnormal_male_reproductive0.71060937
138MP0005248_abnormal_Harderian_gland0.68884238
139MP0002928_abnormal_bile_duct0.68705025
140MP0000015_abnormal_ear_pigmentation0.68642149
141MP0005395_other_phenotype0.65757884
142MP0005367_renal/urinary_system_phenotyp0.65715791
143MP0000516_abnormal_urinary_system0.65715791
144MP0005187_abnormal_penis_morphology0.65432016
145MP0003385_abnormal_body_wall0.64916968
146MP0001299_abnormal_eye_distance/0.64197626
147MP0002111_abnormal_tail_morphology0.62525236

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.36806429
2Chromsome breakage (HP:0040012)5.04878316
3Bilateral microphthalmos (HP:0007633)4.61475694
4Hypochromic microcytic anemia (HP:0004840)4.27317891
5Papillary thyroid carcinoma (HP:0002895)3.69062440
6Rib fusion (HP:0000902)3.56411102
7Intestinal atresia (HP:0011100)3.52619133
8Nephroblastoma (Wilms tumor) (HP:0002667)3.40333764
9Ependymoma (HP:0002888)3.33592734
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.28442353
11Meckel diverticulum (HP:0002245)3.27012220
12Volvulus (HP:0002580)3.16923281
13Rhabdomyosarcoma (HP:0002859)3.16073063
14Embryonal renal neoplasm (HP:0011794)3.13929230
15Abnormality of the ileum (HP:0001549)3.13384027
16Neoplasm of striated muscle (HP:0009728)3.02511756
17Hepatoblastoma (HP:0002884)2.92023702
18Abnormality of chromosome stability (HP:0003220)2.82914987
19Abnormal lung lobation (HP:0002101)2.75785609
20Abnormality of the preputium (HP:0100587)2.72782435
21Impulsivity (HP:0100710)2.70464656
22Small intestinal stenosis (HP:0012848)2.65140133
23Duodenal stenosis (HP:0100867)2.65140133
24Thyroid carcinoma (HP:0002890)2.62777866
25Cortical dysplasia (HP:0002539)2.62108028
26Myelodysplasia (HP:0002863)2.61803839
27Medulloblastoma (HP:0002885)2.61061720
28Multiple enchondromatosis (HP:0005701)2.56000243
29Intestinal fistula (HP:0100819)2.55041317
30Combined immunodeficiency (HP:0005387)2.51640731
31Deep philtrum (HP:0002002)2.48730986
32Biliary tract neoplasm (HP:0100574)2.39803050
33Ectopic kidney (HP:0000086)2.39591334
34Abnormality of the astrocytes (HP:0100707)2.39085769
35Astrocytoma (HP:0009592)2.39085769
36Hypoplasia of the fovea (HP:0007750)2.37639739
37Aplasia/Hypoplasia of the fovea (HP:0008060)2.37639739
38Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.36332243
39Rectovaginal fistula (HP:0000143)2.34328275
40Rectal fistula (HP:0100590)2.34328275
41Gastrointestinal carcinoma (HP:0002672)2.31573310
42Malignant gastrointestinal tract tumors (HP:0006749)2.31573310
43Microglossia (HP:0000171)2.27743583
44Large earlobe (HP:0009748)2.25465007
45Sloping forehead (HP:0000340)2.21829019
46Clubbing of toes (HP:0100760)2.21588996
47Agnosia (HP:0010524)2.21563050
48Obsessive-compulsive behavior (HP:0000722)2.21395037
49Abnormality of chromosome segregation (HP:0002916)2.20887992
50Increased nuchal translucency (HP:0010880)2.20608755
51Oligodactyly (hands) (HP:0001180)2.20548463
52Hypochromic anemia (HP:0001931)2.20508550
53Choanal atresia (HP:0000453)2.20250521
54Preauricular skin tag (HP:0000384)2.20012946
55Aplasia/Hypoplasia of the sternum (HP:0006714)2.19629054
56Abnormality of the fingertips (HP:0001211)2.19252932
57Facial hemangioma (HP:0000329)2.18873533
58Shawl scrotum (HP:0000049)2.18209302
59Gastrointestinal atresia (HP:0002589)2.17464875
60Supernumerary spleens (HP:0009799)2.16872611
61Absent radius (HP:0003974)2.14830639
62Oligodactyly (HP:0012165)2.13869761
63Birth length less than 3rd percentile (HP:0003561)2.13666081
64Neoplasm of the colon (HP:0100273)2.13643277
65Abnormality of the carotid arteries (HP:0005344)2.12597409
66Skin tags (HP:0010609)2.12571107
67Abnormality of the duodenum (HP:0002246)2.12463577
68Abnormality of the phalanges of the hallux (HP:0010057)2.09900425
69Reduced antithrombin III activity (HP:0001976)2.09212181
70Prominent nose (HP:0000448)2.08998735
71Aqueductal stenosis (HP:0002410)2.07195103
72Glioma (HP:0009733)2.06832235
73Uterine leiomyosarcoma (HP:0002891)2.05543453
74Leiomyosarcoma (HP:0100243)2.05543453
75Bifid tongue (HP:0010297)2.04779540
76Abnormal hair whorl (HP:0010721)2.04764583
77Neoplasm of the oral cavity (HP:0100649)2.03243948
78Aplasia/hypoplasia of the humerus (HP:0006507)2.03236428
79Acute myeloid leukemia (HP:0004808)2.02484459
80Short humerus (HP:0005792)2.02400451
81Pendular nystagmus (HP:0012043)2.02376537
82Abnormality of the lower motor neuron (HP:0002366)2.01988041
83Bone marrow hypocellularity (HP:0005528)2.01914377
84Selective tooth agenesis (HP:0001592)1.99533620
85Abnormality of the distal phalanx of the thumb (HP:0009617)1.98922489
86Arteriovenous malformation (HP:0100026)1.98867497
87Short 5th finger (HP:0009237)1.98432086
88Transitional cell carcinoma of the bladder (HP:0006740)1.98059264
89Atresia of the external auditory canal (HP:0000413)1.97074523
90Supernumerary ribs (HP:0005815)1.96594843
91Chin dimple (HP:0010751)1.94487005
92Patellar aplasia (HP:0006443)1.93053333
93Partial duplication of thumb phalanx (HP:0009944)1.92635458
94Absent forearm bone (HP:0003953)1.91536401
95Aplasia involving forearm bones (HP:0009822)1.91536401
96Renal duplication (HP:0000075)1.90519154
97Absent frontal sinuses (HP:0002688)1.90069380
98Abnormality of the left ventricular outflow tract (HP:0011103)1.89692162
99Subaortic stenosis (HP:0001682)1.89692162
100Overlapping toe (HP:0001845)1.88235379
101Broad palm (HP:0001169)1.88125504
102Colon cancer (HP:0003003)1.87095424
103Supernumerary bones of the axial skeleton (HP:0009144)1.86440024
104Neoplasm of the small intestine (HP:0100833)1.86232951
105Neoplasm of the adrenal cortex (HP:0100641)1.85235623
106Aplasia/Hypoplasia of the earlobes (HP:0009906)1.85057822
107Bladder carcinoma (HP:0002862)1.84555877
108Bladder neoplasm (HP:0009725)1.84555877
109Basal cell carcinoma (HP:0002671)1.83766846
110Duplicated collecting system (HP:0000081)1.83413461
111Microtia (HP:0008551)1.82923905
112Sandal gap (HP:0001852)1.82840314
113Chronic hepatic failure (HP:0100626)1.82447710
114Abnormality of the salivary glands (HP:0010286)1.82068001
115Uterine neoplasm (HP:0010784)1.81996540
116Duplication of thumb phalanx (HP:0009942)1.81316522
117Lip pit (HP:0100267)1.80538475
118Tracheoesophageal fistula (HP:0002575)1.80407996
119Curly hair (HP:0002212)1.79831381
120Long clavicles (HP:0000890)1.79438889
121Orchitis (HP:0100796)1.79420549
122Horseshoe kidney (HP:0000085)1.79411747
123Fused cervical vertebrae (HP:0002949)1.79342306
124Vaginal fistula (HP:0004320)1.79146941
125Aplastic anemia (HP:0001915)1.78435370
126Short middle phalanx of the 5th finger (HP:0004220)1.77684985
127Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77418516
128High anterior hairline (HP:0009890)1.76557367
129Neuroblastoma (HP:0003006)1.76296377
130Primitive neuroectodermal tumor (HP:0030065)1.76296377
131Neuroblastic tumors (HP:0004376)1.76296377
132Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.76296377
133Abnormal biliary tract morphology (HP:0012440)1.76283443
134Nasal polyposis (HP:0100582)1.75665615
135Myositis (HP:0100614)1.75057169
136Embryonal neoplasm (HP:0002898)1.74818420
137Anomalous pulmonary venous return (HP:0010772)1.74704006
138Aplasia/Hypoplasia of the patella (HP:0006498)1.74096641
139Panhypogammaglobulinemia (HP:0003139)1.73508270
140Capillary hemangiomas (HP:0005306)1.71826292
141Abnormality of the fovea (HP:0000493)1.71629016
142Neoplasm of the thyroid gland (HP:0100031)1.71009413
143Preauricular pit (HP:0004467)1.70764081
144Periauricular skin pits (HP:0100277)1.70764081
145Partial duplication of the phalanx of hand (HP:0009999)1.70463820
146Preaxial hand polydactyly (HP:0001177)1.69094900
147Long eyelashes (HP:0000527)1.68675694
148Dislocated radial head (HP:0003083)1.68668181
149Anal stenosis (HP:0002025)1.68356758
150Cleft eyelid (HP:0000625)1.66831775
151Triphalangeal thumb (HP:0001199)1.66482961
152Toxemia of pregnancy (HP:0100603)1.66472195
153Cystic hygroma (HP:0000476)1.66340623
154Trismus (HP:0000211)1.66262092
155Nervous tissue neoplasm (HP:0030060)1.66032109
156Neuroectodermal neoplasm (HP:0030061)1.66032109
157Neuroepithelial neoplasm (HP:0030063)1.66032109
158Abnormality of the intervertebral disk (HP:0005108)1.65192758
159Abnormality of the labia minora (HP:0012880)1.63687280
160Cheilitis (HP:0100825)1.63141438
161Abnormality of the prostate (HP:0008775)1.61201067
162Cafe-au-lait spot (HP:0000957)1.61041472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.79031125
2TAF13.08738528
3TTK3.03731808
4CDC72.98759377
5ERN12.89272209
6STK102.85888345
7STK162.82085867
8EIF2AK12.76232511
9GRK62.76103567
10TSSK62.49658339
11GRK52.45956777
12CSF1R2.42576549
13PNCK2.35646999
14EIF2AK32.13815299
15NEK12.09263884
16TGFBR22.07644532
17NEK22.02429929
18CDK72.00478258
19NUAK11.97090028
20ADRBK21.96680842
21GRK11.92846474
22CHEK21.82973424
23TNIK1.80706076
24TRIM281.73230039
25MST41.64689840
26CAMK1G1.64625249
27MATK1.63547627
28BMPR1B1.62556310
29PLK11.60949476
30MAPK71.55489562
31PBK1.48824259
32TXK1.42374478
33BRD41.38626846
34GRK71.37086665
35SRPK11.34995062
36MAP3K101.30122651
37CHEK11.29284084
38WEE11.28053261
39ERBB31.27960638
40ATR1.27808760
41TYRO31.25396215
42FGFR31.24375215
43MAP4K11.18384510
44CDK41.16320359
45EIF2AK21.15904548
46MOS1.14331717
47CCNB11.12698827
48EPHA21.10505908
49LATS11.09834992
50AURKB1.08478898
51PAK41.08377325
52STK31.06721278
53BRSK21.05317139
54STK41.04155558
55PLK41.03860249
56WNK11.03251756
57SMG11.02416834
58VRK21.01816342
59TGFBR11.00090482
60RPS6KB20.99825925
61MAP3K40.98636457
62KSR10.97890436
63BUB10.96872371
64CAMK1D0.96795488
65EEF2K0.96528877
66ATM0.96059840
67CDK80.95908368
68HIPK20.93350167
69BRSK10.90703701
70MKNK20.90663027
71PIM10.88269183
72CAMK40.85382041
73CHUK0.85253912
74IKBKB0.82330200
75MKNK10.81908076
76CDK20.80500396
77JAK30.78782508
78RPS6KA40.75718094
79WNK30.75458873
80PRKG20.74204217
81MARK20.73774080
82DYRK30.73178001
83CSK0.71178436
84MAP4K20.70976103
85MTOR0.70785783
86MARK30.70774063
87ITK0.69539475
88ACVR1B0.66037508
89ZAK0.65546882
90IRAK10.61161784
91MAP3K80.60953369
92KIT0.59697104
93AKT20.59332615
94ALK0.59250924
95BCR0.58282004
96CLK10.57870441
97IRAK20.56467493
98FGFR10.56356711
99CDK90.56248555
100CDK10.55130517
101STK240.54738395
102NME10.54302591
103FRK0.52001354
104CDK30.51791289
105PASK0.50934555
106MELK0.49374637
107TEC0.48831228
108CDK60.48758403
109YES10.48391499
110SIK30.46869274
111VRK10.46797141
112SCYL20.46128475
113ZAP700.43478436
114PLK20.43230379
115MAPK140.42599551
116AKT30.42390217
117ADRBK10.42270848
118BTK0.42218108
119PLK30.41753240
120RAF10.41376749
121HCK0.39900492
122BRAF0.38420553
123MAP3K140.38119366
124CSNK1E0.37964673
125TAOK20.37346298
126IRAK40.36969183
127MAPK10.36862502
128AURKA0.36683334
129STK38L0.36448558
130TYK20.36298465
131BLK0.36264082
132FGFR20.35759165
133PRKDC0.35267672
134LCK0.33474787
135AKT10.33121050
136MAP2K60.32419006
137PRKD20.31753760
138NLK0.30861518
139GSK3B0.30616247
140SIK20.29407228
141FLT30.29306059
142ERBB40.28833211
143MAP2K10.24625601
144RPS6KB10.23875194
145CSNK2A20.23071864
146FGR0.21144836

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.29106840
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22480382
3Fanconi anemia pathway_Homo sapiens_hsa034602.77280010
4Mismatch repair_Homo sapiens_hsa034302.73478226
5Cell cycle_Homo sapiens_hsa041102.62454919
6Homologous recombination_Homo sapiens_hsa034402.48065133
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.33816256
8RNA transport_Homo sapiens_hsa030132.29034045
9Base excision repair_Homo sapiens_hsa034102.27432546
10Vitamin B6 metabolism_Homo sapiens_hsa007502.26293863
11Non-homologous end-joining_Homo sapiens_hsa034502.03991435
12Spliceosome_Homo sapiens_hsa030401.91527791
13One carbon pool by folate_Homo sapiens_hsa006701.87264714
14mRNA surveillance pathway_Homo sapiens_hsa030151.84707822
15RNA degradation_Homo sapiens_hsa030181.80110876
16Primary immunodeficiency_Homo sapiens_hsa053401.77727316
17Proteasome_Homo sapiens_hsa030501.70141987
18Selenocompound metabolism_Homo sapiens_hsa004501.70041543
19Basal transcription factors_Homo sapiens_hsa030221.67853305
20p53 signaling pathway_Homo sapiens_hsa041151.64255610
21Herpes simplex infection_Homo sapiens_hsa051681.61089753
22Nucleotide excision repair_Homo sapiens_hsa034201.56517542
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.46130806
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.44395544
25Protein export_Homo sapiens_hsa030601.35419567
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28565194
27MicroRNAs in cancer_Homo sapiens_hsa052061.25998790
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.23826434
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.23464894
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22500381
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16856658
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14876220
33Steroid biosynthesis_Homo sapiens_hsa001001.13058571
34RNA polymerase_Homo sapiens_hsa030201.13047915
35Thyroid cancer_Homo sapiens_hsa052161.11091764
36Arachidonic acid metabolism_Homo sapiens_hsa005901.08952704
37Measles_Homo sapiens_hsa051621.07188069
38Fructose and mannose metabolism_Homo sapiens_hsa000511.06381243
39Viral carcinogenesis_Homo sapiens_hsa052031.02402954
40HTLV-I infection_Homo sapiens_hsa051661.02188751
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00035089
42Pyrimidine metabolism_Homo sapiens_hsa002400.98444714
43Small cell lung cancer_Homo sapiens_hsa052220.97890299
44Propanoate metabolism_Homo sapiens_hsa006400.97651102
45Antigen processing and presentation_Homo sapiens_hsa046120.97452160
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96861454
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94160105
48Acute myeloid leukemia_Homo sapiens_hsa052210.93594124
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92899843
50Hematopoietic cell lineage_Homo sapiens_hsa046400.91599188
51Notch signaling pathway_Homo sapiens_hsa043300.89371589
52Leishmaniasis_Homo sapiens_hsa051400.89202611
53Pyruvate metabolism_Homo sapiens_hsa006200.88267466
54B cell receptor signaling pathway_Homo sapiens_hsa046620.88246159
55Basal cell carcinoma_Homo sapiens_hsa052170.86943323
56Ribosome_Homo sapiens_hsa030100.86856755
57Pancreatic cancer_Homo sapiens_hsa052120.86702412
58Endometrial cancer_Homo sapiens_hsa052130.85929722
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.85309334
60T cell receptor signaling pathway_Homo sapiens_hsa046600.85284712
61mTOR signaling pathway_Homo sapiens_hsa041500.85191913
62Apoptosis_Homo sapiens_hsa042100.84266975
63Influenza A_Homo sapiens_hsa051640.83058812
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82849763
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80582792
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78407325
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78114786
68Pathways in cancer_Homo sapiens_hsa052000.77492720
69Alcoholism_Homo sapiens_hsa050340.76815056
70Hepatitis B_Homo sapiens_hsa051610.74985986
71Epstein-Barr virus infection_Homo sapiens_hsa051690.74713980
72Galactose metabolism_Homo sapiens_hsa000520.73380155
73Linoleic acid metabolism_Homo sapiens_hsa005910.72325257
74Adherens junction_Homo sapiens_hsa045200.71452560
75Chronic myeloid leukemia_Homo sapiens_hsa052200.71342271
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68545663
77Other glycan degradation_Homo sapiens_hsa005110.67131620
78Colorectal cancer_Homo sapiens_hsa052100.66133816
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65433895
80Non-small cell lung cancer_Homo sapiens_hsa052230.64932572
81Lysine degradation_Homo sapiens_hsa003100.64401071
82Inositol phosphate metabolism_Homo sapiens_hsa005620.63244934
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62324586
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61917420
85Allograft rejection_Homo sapiens_hsa053300.61776571
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61421639
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61344359
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.60261872
89FoxO signaling pathway_Homo sapiens_hsa040680.60093695
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59825721
91Legionellosis_Homo sapiens_hsa051340.59344490
92Melanoma_Homo sapiens_hsa052180.59146879
93Systemic lupus erythematosus_Homo sapiens_hsa053220.58435220
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.57185496
95Hippo signaling pathway_Homo sapiens_hsa043900.56827778
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56738454
97TGF-beta signaling pathway_Homo sapiens_hsa043500.55479356
98Toxoplasmosis_Homo sapiens_hsa051450.54880699
99Hedgehog signaling pathway_Homo sapiens_hsa043400.53676869
100Renal cell carcinoma_Homo sapiens_hsa052110.53530821
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51369578
102Autoimmune thyroid disease_Homo sapiens_hsa053200.50583418
103Biosynthesis of amino acids_Homo sapiens_hsa012300.50495501
104Viral myocarditis_Homo sapiens_hsa054160.49764938
105TNF signaling pathway_Homo sapiens_hsa046680.48244695
106Wnt signaling pathway_Homo sapiens_hsa043100.47977991
107Glioma_Homo sapiens_hsa052140.47556400
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.47501935
109Prostate cancer_Homo sapiens_hsa052150.47069633
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46323227
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45482250
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44668986
113Oocyte meiosis_Homo sapiens_hsa041140.44318618
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43617664
115Proteoglycans in cancer_Homo sapiens_hsa052050.43301495
116Osteoclast differentiation_Homo sapiens_hsa043800.43108394
117ErbB signaling pathway_Homo sapiens_hsa040120.42653595
118Ovarian steroidogenesis_Homo sapiens_hsa049130.42249467
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41745178
120Asthma_Homo sapiens_hsa053100.41375572
121N-Glycan biosynthesis_Homo sapiens_hsa005100.41113947
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40164937
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39617064
124Fatty acid elongation_Homo sapiens_hsa000620.39113237
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38678578
126Purine metabolism_Homo sapiens_hsa002300.38621246
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36988469
128Hepatitis C_Homo sapiens_hsa051600.35902994
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33943796
130Fatty acid biosynthesis_Homo sapiens_hsa000610.28838596
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26814281
132Bladder cancer_Homo sapiens_hsa052190.25865524
133Dorso-ventral axis formation_Homo sapiens_hsa043200.25118800
134Choline metabolism in cancer_Homo sapiens_hsa052310.25072672
135HIF-1 signaling pathway_Homo sapiens_hsa040660.24407358
136Carbon metabolism_Homo sapiens_hsa012000.23689481
137Fatty acid metabolism_Homo sapiens_hsa012120.19488103
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18825311
139Prolactin signaling pathway_Homo sapiens_hsa049170.18149295
140Sphingolipid metabolism_Homo sapiens_hsa006000.17629282
141Glucagon signaling pathway_Homo sapiens_hsa049220.15721207
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15409512

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